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https://www.readbyqxmd.com/read/28212976/functional-lumen-imaging-probe-for-the-management-of-esophageal-disorders-expert-review-from-the-clinical-practice-updates-committee-of-the-aga-institute
#1
REVIEW
Ikuo Hirano, John E Pandolfino, Guy E Boeckxstaens
The functional luminal imaging probe is a Food and Drug Administration-approved measurement tool used to measure simultaneous pressure and diameter to guide management of various upper gastrointestinal disorders. Additionally, this tool is also approved to guide therapy during bariatric procedures and specialized esophageal surgery. Although it has been commercially available since 2009 as the endolumenal functional lumen imaging probe (EndoFLIP), the functional luminal imaging probe has had limited penetrance into clinical settings outside of specialized centers...
March 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28205721/p-28-quality-of-reporting-of-the-literature-on-gastrointestinal-reflux-after-repair-of-esophageal-atresia-tracheoesophageal-fistula
#2
A C Shawyer, J Pemberton, D Kanters, A A A Alnaqi, J M Walton, H Flageole
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28199735/novel-gastric-mucosal-findings-in-association-with-proton-pump-inhibitors
#3
EDITORIAL
Hajime Isomoto, Hiroki Kurumi
Proton pump inhibitors (PPIs) are prescribed worldwide as the treatment of choice for gastroesophageal reflux disease, and are known to exert preventive effects for upper gastrointestinal injuries due to aspirin or non-steroidal anti-inflammatory drugs. On the other hand, the long-term use of PPIs may cause such adverse events as fractures and enteric infections. Recently, they have been associated with mucosal changes including parietal cell protrusions, oxyntic gland dilatations and fundic gland polyps (FGPs)...
February 15, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28192647/a-double-blind-randomized-multicenter-clinical-trial-investigating-the-efficacy-and-safety-of-esomeprazole-single-therapy-versus-mosapride-and-esomeprazole-combined-therapy-in-patients-with-esophageal-reflux-disease
#4
Ju Yup Lee, Sung Kook Kim, Kwang Bum Cho, Kyung Sik Park, Joong Goo Kwon, Jin Tae Jung, Eun Young Kim, Byung Ik Jang, Si Hyung Lee
Background/Aims: We aimed to evaluate the efficacy and safety of combination therapy in erosive reflux disease (ERD) patients by comparing endoscopic healing rate according to the Los Angeles classification for esomeprazole alone and esomeprazole plus mosapride. Methods: A total of 116 ERD patients were randomized to receive esomeprazole 40 mg once daily plus mosapride 5 mg 3 times daily (E+M group), or esomeprazole plus placebo (E only group) for 8 weeks. Patients recorded gastroesophageal reflux disease (GERD) symptom questionnaire at week 4 and 8...
February 13, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28192107/gastrointestinal-complications-of-obesity
#5
Michael Camilleri, Harmeet Malhi, Andres Acosta
Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. non-alcoholic fatty liver diseases (NAFLD)] or is a significant risk factor, such as reflux esophagitis and gallstones. When obesity is a risk factor, it may interact with other mechanisms and result in earlier presentation or complicated diseases. There are increased odds ratios or relative risks of several gastrointestinal complications of obesity: gastroesophageal reflux disease (GERD), erosive esophagitis, Barrett's esophagus, esophageal adenocarcinoma, erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver disease including NAFLD, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28191707/mechanisms-underlying-reflux-symptoms-and-dysphagia-in-patients-with-joint-hypermobility-syndrome-with-and-without-postural-tachycardia-syndrome
#6
A Fikree, Q Aziz, D Sifrim
BACKGROUND: The joint hypermobility syndrome (JHS) is a common non-inflammatory connective tissue disorder which frequently co-exists with postural tachycardia syndrome (PoTS), a form of orthostatic intolerance. Gastrointestinal symptoms and dysmotility have been reported in PoTS. Dysphagia and reflux are common symptoms in JHS, yet no studies have examined the physiological mechanism for these, subdivided by PoTS status. METHODS: Thirty patients (28 female, ages: 18-62) with JHS and symptoms of reflux (n=28) ± dysphagia (n=25), underwent high-resolution manometry and 24 hour pH-impedance monitoring after questionnaire-based symptom assessment...
February 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28157428/incidence-of-biliary-reflux-esophagitis-after-laparoscopic-omega-loop-gastric-bypass-in-morbidly-obese-patients
#7
Tamer M Said Salama, Mohamed Ibrahim Hassan
BACKGROUND: Omega loop gastric bypass is a successful bariatric surgery with numerous favorable circumstances as being basic, effective on weight reduction and treatment of obesity associated metabolic disorder, the short expectation to learn and adapt, and the simplicity of correction and inversion. However, there are arguments about the possibility of biliary reflux and/or the potential danger of gastroesophageal malignancy after the procedure. METHODS: Fifty patients experiencing morbid obesity with body mass index >40 or >35 kg/m(2) with two related comorbidities, for example, diabetes type II, hypertension, or dyslipidemia, underwent omega loop gastric bypass with a follow-up period up to 18 months, investigating for any symptom of reflux infection by upper gastrointestinal tract endoscopy and pH metry...
February 3, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28155231/charge-syndrome-gastrointestinal-involvement-from-mouth-to-anus
#8
REVIEW
A Hudson, M Macdonald, J N Friedman, K Blake
CHARGE syndrome is an autosomal dominant disorder that occurs as a result of a heterozygous loss-of-function mutation in the chromodomain helicase DNA-binding (CHD7) gene, which is important for neural crest cell formation. Gastrointestinal (GI) symptoms and feeding difficulties are highly prevalent but are often a neglected area of diagnosis, treatment, and research. Cranial nerve dysfunction, craniofacial abnormalities, and other physical manifestations of this syndrome lead to gut dysmotility, sensory impairment, and oral-motor function abnormalities...
October 13, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/28151867/an-analysis-of-342-patients-with-refractory-gastroesophageal-reflux-disease-symptoms-using-questionnaires-high-resolution-manometry-and-impedance-ph-monitoring
#9
Fei Wang, Ping Li, Guo-Zhong Ji, Lin Miao, Zhining Fan, Sihong You, Xueqin Pan, Xia Chen
Symptoms of refractory gastroesophageal reflux disease (GERD) are commonly encountered in clinical practice. The aim of this study was to analyze the data obtained from questionnaires, high-resolution manometry (HRM), and ambulatory impedance-pH monitoring in patients with persisting GERD symptoms and to explore the possible underlying causes for this clinical presentation. After completing the questionnaires, the selected patients underwent endoscopy, HRM, and ambulatory impedance-pH monitoring. Based on the results of these investigations, we divided the patients into 4 groups: reflux esophagitis (RE), hypersensitive esophagus (HE), functional heartburn (FH), and nonerosive gastroesophageal reflux disease (NERD)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28148574/peroral-endoscopic-myotomy-a-literature-review-and-the-first-uk-case-series
#10
Shraddha Gulati, Andrew Emmanuel, Haruhiro Inoue, Bu'Hussain Hayee, Amyn Haji
Peroral endoscopic myotomy (POEM) is an established treatment for primary achalasia. It has gained endorsement from the American Society for Gastrointestinal Endoscopy with increasing clinical acceptance since the first procedure, performed in Japan in 2008. The first successful POEM in the UK was performed in November 2013 at King's College Hospital and this article presents the first UK case series. Prospective data were collected at 3 and 12-24 months for consecutive patients undergoing POEM. Post-POEM gastro-oesophageal reflux health-related quality of life scale (GORD-HRQoL) score was recorded...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28147346/foods-inducing-typical-gastroesophageal-reflux-disease-symptoms-in-korea
#11
Jung Wan Choe, Moon Kyung Joo, Hyo Jung Kim, Beom Jae Lee, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Jae Seon Kim, Kwan Soo Byun, Young-Tae Bak
Background/Aims: Several specific foods are known to precipitate gastroesophageal reflux disease (GERD) symptoms and GERD patients are usually advised to avoid such foods. However, foods consumed daily are quite variable according to regions, cultures, etc. This study was done to elucidate the food items which induce typical GERD symptoms in Korean patients. Methods: One hundred and twenty-six Korean patients with weekly typical GERD symptoms were asked to mark all food items that induced typical GERD symptoms from a list containing 152 typical foods consumed daily in Korea...
January 31, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28147345/taste-and-smell-disturbances-in-patients-with-gastroparesis-and-gastroesophageal-reflux-disease
#12
Alisha Kabadi, Mohammed Saadi, Ron Schey, Henry P Parkman
Background/Aims: Patients with gastroparesis and gastroesophageal reflux disease (GERD) often report decreased enjoyment when eating. Some patients remark that food does not smell or taste the same. To determine if taste and/or smell disturbances are present in patients with gastroparesis and/or GERD and relate these to gastrointestinal symptom severity. Methods: Patients with gastroparesis and/or GERD completed questionnaires evaluating taste and smell (Taste and Smell Survey [TSS]), Patient Assessment of Upper Gastrointestinal Symptom Severity Index (PAGI-SYM), and demographics...
February 1, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28141547/efficacy-of-and-potential-morbidities-associated-with-the-use-of-antacid-medications-in-preterm-neonates
#13
Uday P Patil, Sean M Bailey, Elena V Wachtel, Evan Orosz, Rebecca Zarchin, Pradeep V Mally
OBJECTIVES: Antacid medications are frequently administered to preterm infants. These medications can change gastric pH levels and can affect regular gastrointestinal function and gut micro-bacterial flora. We hypothesized that preterm infants exposed to antacid medications are at a greater risk of necrotizing enterocolitis (NEC) and sepsis, and set out to determine any association, as well as to assess the clinical efficacy of these medications. MATERIALS AND METHODS: Retrospective chart review of preterm infants ≤30 weeks' gestational age or birth weight ≤1250 g over a 2-year period at New York University Langone Medical Center...
January 31, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28134128/atrial-fibrillation-and-sympathovagal-balance-in-patients-with-gastroesophageal-reflux-disease
#14
Mariana Floria, Oana Bărboi, Mihaela Grecu, Cristina Cijevschi Prelipcean, Gheorghe Balan, Vasile Liviu Drug
BACKGROUND/AIMS: Similar autonomic innervation of the esophagus and left atrium with sympathovagal imbalance seems to explain the association between non-valvular atrial fibrillation (AF) and gastroesophageal reflux disease (GERD). We aimed to assess this association via parameters of heart rate variability in time (SDNN) and frequency (low-frequency (LF)/high-frequency (HF) ratio) domains by 24-hour electrocardiographic (ECG) Holter monitoring. MATERIALS AND METHODS: One hundred thirty-five patients were prospectively included by a joint team consisting of a gastroenterologist and a cardiologist on the basis of the patients' complaints...
January 30, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28127205/factors-associated-with-complicated-erosive-esophagitis-a-japanese-multicenter-prospective-cross-sectional-study
#15
Masahiro Sakaguchi, Noriaki Manabe, Nobuo Ueki, Jun Miwa, Tomoki Inaba, Norimasa Yoshida, Kouichi Sakurai, Masahiro Nakagawa, Hajime Yamada, Michiya Saito, Koji Nakada, Katsuhiko Iwakiri, Takashi Joh, Ken Haruma
AIM: To assess the clinical characteristics of patients with complicated erosive esophagitis (EE) and their associated factors. METHODS: This prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28124156/helicobacter-pylori-induced-changes-in-gastric-acid-secretion-and-upper-gastrointestinal-disease
#16
Adam J Smolka, Mitchell L Schubert
Appropriate management of Helicobacter pylori infection of the human stomach is evolving and remains a significant clinical challenge. Acute infection results in hypochlorhydria, whereas chronic infection results in either hypo- or hyperchlorhydria, depending upon the anatomic site of infection. Acute hypochlorhydria facilitates survival of the bacterium and its infection of the stomach. Interestingly, most patients chronically infected with H. pylori manifest a pangastritis with reduced acid secretion due to bacterial virulence factors, inflammatory cytokines, and various degrees of gastric atrophy...
2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28104150/comparison-of-mizoribine-and-mycophenolate-mofetil-with-a-tacrolimus-based-immunosuppressive-regimen-in-living-donor-kidney-transplantation-recipients-a-retrospective-study-in-china
#17
Y Shi, H Liu, X-G Chen, Z-Y Shen
BACKGROUND: A retrospective study was conducted to investigate the prevalence of gastrointestinal (GI) symptoms as well as the efficacy and safety of mizoribine (MZR) and mycophenolate mofetil (MMF) in Chinese living-donor kidney transplantation (LDKT). METHODS: Forty-two recipients enrolled between January 2012 and March 2014 were treated with either MZR (n = 22) or MMF (n = 20). All patients were treated in combination with a tacrolimus-based immunosuppressive regimen, besides the study drugs...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28101304/gastric-antral-webs-in-adults-a-case-series-characterizing-their-clinical-presentation-and-management-in-the-modern-endoscopic-era
#18
Shannon J Morales, Neha Nigam, Walid M Chalhoub, Dalia I Abdelaziz, James H Lewis, Stanley B Benjamin
AIM: To investigate the current management of gastric antral webs (GAWs) among adults and identify optimal endoscopic and/or surgical management for these patients. METHODS: We reviewed our endoscopy database seeking to identify patients in whom a GAW was visualized among 24640 esophagogastroduodenoscopies (EGD) over a seven-year period (2006-2013) at a single tertiary care center. The diagnosis of GAW was suspected during EGD if aperture size of the antrum did not vary with peristalsis or if a "double bulb" sign was present on upper gastrointestinal series...
January 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28096866/disseminated-strongyloidiasis-in-an-iranian-immunocompromised-patient-a-case-report
#19
Narges Najafi, Eissa Soleymani, Shahabeddin Sarvi, Amirkeivan Marofi, Anahita Nosrati, Alireza Davoodi
Strongyloides stercoralis is a soil-transmitted helminth (STH) widespread in various part of the world. A 78-yr-old peasant diabetic female from Mazandaran Province northern Iran, was admitted to Infection Department of the Razi Hospital in city of Qaemshahr, north of Iran complaining about abdominal skin rash, pruritus, itching, anorexia, nausea, vomiting, dysuria and cough. This patient had cutaneous migration effects of S. stercoralis larvae in her abdominal skin (larva currents and urticaria). Lung CT without contrast demonstrate s bilateral diffuse ground glass opacity draws attention...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28091435/influence-of-helicobacter-pylori-infection-on-the-prevalence-and-patterns-of-upper-gastrointestinal-symptoms-in-nigerians-with-diabetes-mellitus
#20
A Oluyemi, E Anomneze, S Smith, O Fasanmade
BACKGROUND: Infection with Helicobacter pylori infection is widespread in our environment. However, whether this fact has any bearing on the prevalence and pattern of symptoms referable to the upper gastrointestinal (GI) system in our population of diabetes mellitus (DM) patients has not been much studied. AIM: We embarked on this study to evaluate if H. pylori infection played any significant role in the prevalence and patterns of upper GI symptoms in type 2 DM patients in Lagos, Nigeria...
February 2017: Nigerian Journal of Clinical Practice
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