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https://www.readbyqxmd.com/read/29339948/update-on-functional-heartburn
#1
Takahisa Yamasaki, Jessica O'Neil, Ronnie Fass
The definition of functional heartburn has been refined over the years. It is currently described, based upon Rome IV criteria, as typical heartburn symptoms in the presence of normal upper endoscopy findings (including normal biopsies), normal esophageal pH testing, and a negative association between symptoms and reflux events. Functional heartburn is very common, affecting women more than men, and with reflux hypersensitivity makes up the majority of heartburn patients who fail twice-daily proton pump inhibitor therapy...
December 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29333061/critical-appraisal-of-rome-iv-criteria-hypersensitive-esophagus-does-belong-to-gastroesophageal-reflux-disease-spectrum
#2
REVIEW
Leonardo Frazzoni, Marzio Frazzoni, Nicola de Bortoli, Salvatore Tolone, Irene Martinucci, Lorenzo Fuccio, Vincenzo Savarino, Edoardo Savarino
The Rome IV Committee introduced a major change in the classification of functional gastrointestinal disorders, proposing a more restrictive definition of gastroesophageal reflux disease (GERD). It was suggested that hypersensitive esophagus (HE) may sit more firmly within the functional realm. It was suggested that GERD diagnosis should be based upon abnormal acid exposure time (AET) only, implying no advantage of impedance-pH over pH monitoring. Symptom association probability (SAP), symptom index (SI) and heartburn relief with proton pump inhibitor (PPI) therapy were regarded as unreliable, whereas a lack of response to PPI was considered as evidence of functional heartburn...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29324645/esophageal-web-in-a-down-syndrome-infant-a-rare-case-report
#3
Nirmala Thomas, Roy J Mukkada, Muhammed Jasim Abdul Jalal, Nisha Narayanankutty
We describe the rare case of an infant with trisomy 21 who presented with recurrent vomiting and aspiration pneumonia and a failure to thrive. Infants with Down's syndrome have been known to have various problems in the gastrointestinal tract. In the esophagus, what have been described are dysmotility, gastroesophageal reflux and strictures. This infant on evaluation was found to have an esophageal web and simple endoscopic dilatation relieved the infant of her symptoms. No similar case has been reported in literature...
January 11, 2018: Children
https://www.readbyqxmd.com/read/29313514/upper-gastrointestinal-tract-endoscopic-lesions-in-a-rural-african-hospitalo-252%C3%A2-endoscopies-at-the-kara-university-hospital-togo
#4
O Bouglouga, A Bagny, L M Lawson-Ananissoh, K Amanga, R El-Hadj Yakoubou, L Kaaga, M Djibril, D Redah
To analyze the indications for upper gastrointestinal endoscopy (UGIE) and determine the frequency of the pathological findings observed in rural areas of Africa. This retrospective study includes 9 series of 5-day visits to perform these examinations. Patients were informed of the presence of the endoscopy team by a bulletin on a rural radio station and by general practitioners at the Kara University Hospital. Patients were recruited from the hospital clinics and from the general population of the Kara region...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29313277/does-sleeve-shape-make-a-difference-in-outcomes
#5
Adel Alhaj Saleh, Michal R Janik, Rami R Mustafa, Mohammed Alshehri, Adil H Khan, Seyed Mohammad Kalantar Motamedi, Shiraz Rahim, Indravadan Patel, Amir Aryaie, Mujjahid Abbas, Tomasz Rogula, Leena Khaitan
INTRODUCTION: Sleeve gastrectomy (SG) is one of the most common procedures performed for weight loss. Many seek the "perfect sleeve" with the notion that the type of calibrating device affects sleeve shape, and this in turn will affect outcomes and complications. Two major concerns after SG are amount of weight loss and acid reflux. Our aim was to determine if the various calibration methods could impact sleeve shape and thereby allow for better outcomes of weight loss and reflux. METHODS: A retrospective chart review was performed of 210 patients who underwent SG and had postoperative upper gastrointestinal (UGI) study from 2011 to 2015 in a single center by a single (fellowship-trained) bariatric surgeon...
January 8, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29311037/relationships-among-dietary-intakes-and-persistent-gastrointestinal-symptoms-in-patients-receiving-enzyme-treatment-for-genetic-sucrase-isomaltase-deficiency
#6
Anne Boney, Heather E Elser, Heidi J Silver
BACKGROUND: Sucrose-isomaltase deficiency (SID) remains underdiagnosed. Absent or reduced enzyme activity promotes diarrhea, abdominal bloating, and flatulence from undigested and malabsorbed disaccharides. Frequency and severity of gastrointestinal symptoms may be associated with the type of carbohydrates consumed. OBJECTIVE: To characterize the dietary intakes of patients treated with sacrosidase (Sucraid; QOL Medical) for SID and determine relationships between type of carbohydrates, sacrosidase dose, and gastrointestinal symptoms...
January 5, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29286026/-quality-of-life-of-patients-with-complicated-reflux-esophagitis-followed-antireflux-surgery
#7
A F Chernousov, T V Khorobrykh, F P Vetshev, T I Ionova, D Mugadzaveta, S V Osminin, T P Nikitina
AIM: To analyze quality of life of patients with complicated reflux-esophagitis followed antireflux surgery. MATERIAL AND METHODS: The trial enrolled 200 patients who underwent surgical treatment at the Burdenko Faculty Surgery Clinic of Sechenov First Moscow State Medical University for complicated reflux esophagitis from 2008 to 2015. Inclusion criteria were long-standing reflux esophagitis irresistible to conservative treatment, hiatal hernia with shortening of the esophagus and/or peptic stricture and/or Barrett's esophagus...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29248733/esophageal-mucosal-impedance-patterns-discriminate-patients-with-eosinophilic-esophagitis-from-patients-with-gerd
#8
Yash Choksi, Pooja Lal, James C Slaughter, Rohit Sharda, Jacob Parnell, Tina Higginbotham, Michael F Vaezi
BACKGROUND & AIMS: It is a challenge to make a diagnosis of eosinophilic esophagitis (EoE) because its symptoms and histologic features overlap with those of gastroesophageal reflux disease (GERD). A minimally invasive device was recently developed to detect mucosal impedance (MI) that measures epithelial integrity during upper endoscopy. We aimed to quantify MI along the esophagus and identify patterns that differentiated patients with and without GERD from those with EoE, and determine whether MI values and patterns are sufficient to identify patients with EoE using histologic findings as a reference...
December 14, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29246457/the-effectiveness-and-safety-of-laparoscopic-sleeve-gastrectomy-with-different-sizes-of-bougie-calibration-a-systematic-review-and-meta-analysis
#9
REVIEW
Yao Wang, Xiao-Yan Yi, Li-Lin Gong, Qi-Fu Li, Jun Zhang, Zhi-Hong Wang
OBJECTIVES: This systematic review and meta-analysis was performed to compare the influence of different calibrating bougie sizes on clinical outcomes in laparoscopic sleeve gastrectomy (LSG) for patients with obesity. MATERIALS AND METHODS: A systematic review of the literature was performed using the key words: "laparoscopic sleeve gastrectomy", "bougie size", "calibration", "obesity", and "obese" for searches of electronic databases up to October 2017. Clinical characteristics such as, the percentage of excess weight loss (%EWL), overall complications, gastrointestinal leaks, gastroesophageal reflux disease (GERD) were pooled by meta-analysis...
December 12, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29234058/relation-of-ultrasound-findings-and-abdominal-symptoms-obtained-with-the-cfabd-score-in-cystic-fibrosis-patients
#10
Harold Tabori, Anke Jaudszus, Christin Arnold, Hans-Joachim Mentzel, Michael Lorenz, Ruth K Michl, Thomas Lehmann, Diane M Renz, Jochen G Mainz
Abdominal symptoms are a hallmark of Cystic fibrosis (CF). Yet, their association with morphological abnormalities of different abdominal organs is still poorly understood. Aim was therefore to relate these symptoms, assessed with a questionnaire, to findings in abdominal ultrasound (US). In 114 CF patients of all ages, findings in US considering seventeen specific parameters were related to abdominal symptoms compiled with our novel CF-specific 26-modal symptom score (CFAbd-Score). US abnormalities were detected in 95% of the patients...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29230485/-importance-of-functional-diagnostics-in-gastroenterology
#11
REVIEW
M Hollenbach, A Hoffmeister, J Rosendahl, J Mössner
In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test can be carried out when there is a suspicion of abnormal intestinal bacterial colonization and using lactulose for measuring small intestinal transit time...
December 11, 2017: Der Internist
https://www.readbyqxmd.com/read/29229450/gastric-emptying-time-esophageal-ph-impedance-parameters-quality-of-life-and-gastrointestinal-comorbidity-in-obese-children-and-adolescents
#12
Paolo Quitadamo, Letizia Zenzeri, Enza Mozzillo, Irene Cuccurullo, Alba Rocco, Adriana Franzese, Gerardo Nardone, Annamaria Staiano
OBJECTIVES: To provide further evidence regarding the relationship between obesity and gastroesophageal reflux disease (GERD) in children, through the use of 13C-octanoic acid breath test for gastric emptying time (GET) assessment and esophageal multichannel intraluminal impedance pH-testing (MII-pH). STUDY DESIGN: Obese children aged 4-17 years completed a questionnaire investigating reflux symptoms, the presence of functional gastrointestinal disorders, and quality of life...
December 8, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29225270/iga-vasculitis-with-simultaneous-cardiopulmonary-involvement-a-case-report
#13
Kazunori Bando, Hirofumi Maeba, Ichiro Shiojima
A 60-year-old man with a history of hypertension, type 2 diabetes, and reflux esophagitis was admitted to our hospital with hemoptysis, dyspnea, and leg edema. We diagnosed him with adult IgA vasculitis based on the presence of purpura, elevated serum IgA fibronectin complexes, pathophysiological findings, a skin biopsy showing leukocytoclastic vasculitis, and immunofluorescence studies demonstrating granular IgA and C3 deposits in the blood vessel wall. He showed concurrent cardiopulmonary involvement without involvement of the gastrointestinal system and kidneys, which are commonly affected in IgA vasculitis patients...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29199167/which-diseases-are-risk-factors-for-developing-gastroesophageal-reflux-disease
#14
Filiz Akyüz, Özlem Mutluay Soyer
Although the pathophysiology of gastroesophageal reflux disease (GERD) remains unclear, it is accepted as a multifactorial disease. It is thought that some of the interventions that might cause alterations in the normal gastrointestinal tract anatomy and diseases that affect the lower esophageal sphincter, esophageal clearance, and stomach motility (gastric emptying) might lay a foundation for GERD development. Moreover, it is common knowledge that GERD might cause various extraesophageal symptoms and complications...
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29199162/to-whom-and-when-the-upper-gastrointestinal-endoscopy-is-indicated-in-gastroesophageal-reflux-disease-what-is-the-role-of-routine-esophageal-biopsy-which-endoscopic-esophagitis-classification-should-be-used
#15
Taylan Kav
Gastroesophageal reflux disease (GERD) is a chronic disease characterized with heartburn and regurgitation symptoms. The prevalence of these symptoms in Turkey is reported to be as high as 20%. GERD negatively effects the quality of life along with the development of some complications due to chronic course. Upper gastrointestinal endoscopy is commonly performed for diagnosis and surveillance of complications in the context of GERD. However, there is no consensus in terms of timing and indications for endoscopy, use of esophagitis classification system, to obtain a biopsy sample or recommendation for surveillance endoscopy...
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29199160/what-is-the-place-of-empirical-proton-pump-inhibitor-testing-in-the-diagnosis-of-gastroesophageal-reflux-disease-description-duration-and-dosage
#16
Rukiye Vardar, Muharrem Keskin
Empirical acid suppression tests that are performed with proton pump inhibitors (PPI) are used to detect both the presence of acid-related gastrointestinal symptoms and gastroesophageal reflux disease (GERD). In comparison to other diagnostic methods, it is non-invasive, easily applicable, and cost-effective in the diagnosis of GERD. In addition to typical reflux symptoms, it can also be used for diagnostic purposes in patients with non-cardiac chest pain (NCCP). If the symptom response is 50% and above when obtained using the PPI test in patients with NCCP, it can be considered as positive and the treatment should be continued sensitivity of the PPI test in patients with typical symptoms of GERD is 27%-89%, while its specificity is 35%-83%...
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29192375/efficacy-of-rebamipide-in-organic-and-functional-dyspepsia-a-systematic-review-and-meta-analysis
#17
Mohamed Hasif Jaafar, Sher Zaman Safi, Maw-Pin Tan, Sanjay Rampal, Sanjiv Mahadeva
OBJECTIVE: The role of gastritis in dyspepsia remains controversial. We aimed to examine the efficacy of rebamipide, a gastric mucosal protective agent, in both organic and functional dyspepsia. DESIGN: A systematic review and meta-analysis was performed. The following databases were searched using the keywords ("rebamipide" OR "gastroprotective agent*" OR "mucosta") AND ("dyspepsia" OR "indigestion" OR "gastrointestinal symptoms"): PubMed, Wed of Science, Embase, CINAHL, Cochrane Clinical Trials Register...
December 1, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29189428/wake-up-call-to-clinicians-the-impact-of-sleep-dysfunction-on-gastrointestinal-health-and-disease
#18
Parth J Parekh, Edward C Oldfield, David A Johnson
Sleep dysfunction is an epidemic affecting a large portion of the adult population. Recent studies have linked sleep dysfunction with an upregulation of proinflammatory cytokines (eg, tumor necrosis factor-α, interleukin-1 and interleukin-6), the implications of which can have a profound impact on a variety of gastrointestinal disease. In particular, sleep dysfunction seems to accelerate disease states characterized by inflammation (eg, gastroesophageal reflux disease, irritable bowel syndrome and functional dyspepsia, chronic liver disease, inflammatory bowel disease, and colorectal cancer)...
November 17, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29180295/antimicrobial-and-bactericidal-impacts-of-bacillus-amyloliquefaciens-cect-5940-on-fecal-shedding-of-pathogenic-bacteria-in-dairy-calves-and-adult-dogs
#19
Paulina Vazquez-Mendoza, Mona M M Elghandour, Peter Adeniyi Alaba, Pedro Sánchez-Aparicio, María Uxúa Alonso-Fresán, Alberto Barbabosa-Pliego, Abdelfattah Z M Salem
Two experiments were carried out to evaluate the bactericidal impacts of Bacillus amyloliquefaciens CECT 5940 on the shedding of faecal pathogenic bacteria in dairy calves (Experimnt 1) and in adults dogs (expeiriment 2). In the calves experiment, a completely randomized design was used to investigate the faecal bacteria profile of Holstein dairy calves fed with either pasteurized waste milk (PWM; n = 9) or a formulated non-medicated milk replacer (NMR; n = 9) for 60 d. The NMR containing sodium-butyrate and the active probiotic B...
November 24, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29174961/effect-of-premedication-with-butorphanol-or-methadone-on-ease-of-endoscopic-duodenal-intubation-in-dogs
#20
William Jm McFadzean, Edward J Hall, Hugo van Oostrom
OBJECTIVE: The effect of premedication with butorphanol or methadone on ease of endoscopic duodenal intubation. STUDY DESIGN: Prospective, randomized, blinded clinical trial. ANIMALS: A group of 20 client-owned dogs. METHODS: Dogs were assigned randomly to be administered intravenous (IV) premedication with either butorphanol (0.4 mg kg-1) or methadone (0.3 mg kg-1). General anaesthesia was induced with propofol to effect and maintained with isoflurane in 100% oxygen...
June 7, 2017: Veterinary Anaesthesia and Analgesia
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