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https://www.readbyqxmd.com/read/28718286/functionalized-selenium-nanosystem-as-radiation-sensitizer-of-125i-seeds-for-precise-cancer-therapy
#1
Yahui Yang, Qiang Xie, Zhennan Zhao, Lizhen He, Leung Chan, Yingxiang Liu, Yongle Chen, Mingjun Bai, Tao Pan, Yanni Qu, Long Ling, Tianfeng Chen
Although radiotherapy has been extensively applied in cancer treatment, external beam radiation therapy is still difficult to avoid damage to adjacent normal tissues in the process of delivering a sufficient radiation dose to the tumor sites of patients. To overcome this limitation, chemoradiotherapy, as a combination of chemotherapy and radiotherapy of radioactive seed, has been proposed to decrease the damage for tumor surrounding tissues and enhance the radiosensitivity of solid tumors. In the study, we designed and synthesized folic acid-conjugated selenium nanoparticles (FA@SeNPs) as cancer-targeting agent, which could be synergistically enhanced by the radioactive 125I seeds to realize anticancer efficacy and inhibited colony formation ability...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718265/haemoglobinuria-and-portal-venous-thrombosis-in-a-young-male
#2
Zain Ul Abideen, Munnam Sohail Jafar, Nasir Hameed, Ahmad Malik
Paroxysmal nocturnal haemoglobinuria is a non-malignant stem cell disorder due to acquired somatic mutations in cell surface anchored proteins CD55 and CD59. Both have a compliment inhibitory role and their deficiency leads to intravascular haemolysis. This paper reports a challenging case of a 25 years old male who presented with generalized weakness, exertional dyspnoea and episodic early morning haematuria. Recently, he started developing progressive abdominal distention and dull generalized abdominal pain...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28717270/antioxidant-therapy-in-idiopathic-oligoasthenoteratozoospermia
#3
REVIEW
Ahmad Majzoub, Ashok Agarwal
INTRODUCTION: Idiopathic oligoasthenoteratozoospermia (iOAT) is commonly encountered during the evaluation of men with infertility. Antioxidants have been utilized empirically in the treatment of iOAT based on their ability to reverse oxidative stress (OS)-induced sperm dysfunction often encountered in this patient population. METHODS: A literature search was performed using MEDLINE/PubMed, focusing on publications of antioxidant therapies for iOAT. The main objective of our review article was to report the rationale and available evidence supporting the use of antioxidants...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28715482/impact-of-maternal-body-mass-index-and-gestational-weight-gain-on-neonatal-outcomes-among-healthy-middle-eastern-females
#4
Tatiana Papazian, Georges Abi Tayeh, Darine Sibai, Hala Hout, Imad Melki, Lydia Rabbaa Khabbaz
BACKGROUND: Studies on the relative impact of body mass index in women in childbearing age and gestational weight gain on neonatal outcomes are scarce in the Middle East. OBJECTIVES: The primary objective of this research was to assess the impact of maternal body mass index (BMI) and gestational weight gain (GWG) on neonatal outcomes. The effect of maternal age and folic acid supplementation before and during pregnancy was also examined. SUBJECTS AND METHODS: This is a retrospective cross sectional observational study of 1000 full term deliveries of women enrolled thru the National Collaborative Perinatal Neonatal Network, in Lebanon...
2017: PloS One
https://www.readbyqxmd.com/read/28715002/cationic-folate-mediated-liposomal-delivery-of-bis-arylidene-oxindole-induces-efficient-melanoma-tumor-regression
#5
Chandra Kumar Elechalawar, Kathyayani Sridharan, Abhishek Pal, Mohammed Tanveer Ahmed, Mohammed Yousuf, Susanta Sekhar Adhikari, Rajkumar Banerjee
The folate receptor (FR) is a well-validated and common target for cancer due to its high over-expression in many different cancer cells. Herein, we developed a new FR-targeting ligand (FA8) by conjugating folic acid and a cationic lipid. Owing to its favorable structural property FA8 as a ligand could be accommodated at an unusually higher molar ratio for a ligand-targeted liposome. We then encapsulated a drug-like molecule, bis-arylidene oxindole (NME2), in the targeted liposome. The resulting formulation induced potent caspase-8 up-regulation even in FR-moderately expressing melanoma cells...
July 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28708254/preconceptional-folic-acid-supplementation-in-japan
#6
Fumiki Hirahara, Haruka Hamanoue, Kentaro Kurasawa
Since 2000, preconceptional folic acid supplementation has been recommended in Japan. In Japan, lack of active campaign and attitude of women for folic acid intake has retained behind situation as compared to western countries. In the present review, we traced past and present practice and discuss the issues surrounding folate intake both before and after conception.
July 14, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28706267/a-simple-add-and-display-method-for-immobilisation-of-cancer-drug-on-his-tagged-virus-like-nanoparticles-for-controlled-drug-delivery
#7
Roya Biabanikhankahdani, Saadi Bayat, Kok Lian Ho, Noorjahan Banu Mohamed Alitheen, Wen Siang Tan
pH-responsive virus-like nanoparticles (VLNPs) hold promising potential as drug delivery systems for cancer therapy. In the present study, hepatitis B virus (HBV) VLNPs harbouring His-tags were used to display doxorubicin (DOX) via nitrilotriacetic acid (NTA) conjugation. The His-tags served as pH-responsive nanojoints which released DOX from VLNPs in a controlled manner. The His-tagged VLNPs conjugated non-covalently with NTA-DOX, and cross-linked with folic acid (FA) were able to specifically target and deliver the DOX into ovarian cancer cells via folate receptor (FR)-mediated endocytosis...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705466/serum-folic-acid-levels-are-associated-with-the-presence-and-severity-of-liver-steatosis-in-chinese-adults
#8
Ming-Feng Xia, Hua Bian, Xiao-Peng Zhu, Hong-Mei Yan, Xin-Xia Chang, Lin-Shan Zhang, Huan-Dong Lin, Xi-Qi Hu, Xin Gao
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a common and strong risk factor for cardiovascular disease and hepatocellular carcinoma. The rapid acceleration of the increase in NAFLD prevalence has exceeded the trends observed for obesity, and has been driven by multiple factors. The aim of this study was to investigate the correlation between the serum levels of folic acid, the endogenous source of methyl groups for DNA methylation, and NAFLD in Chinese adults. METHODS: The correlations between the serum folic acid levels and NAFLD were investigated in two independent cohorts of 70 subjects who underwent a liver biopsy and 130 subjects with varying liver fat contents, as measured using proton magnetic resonance spectroscopy ((1)H-MRS)...
June 28, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28705434/nanoparticle-macrophage-interactions-a-balance-between-clearance-and-cell-specific-targeting
#9
Rahul Rattan, Somnath Bhattacharjee, Hong Zong, Corban Swain, Muneeb A Siddiqui, Scott H Visovatti, Yogendra Kanthi, Sajani Desai, David J Pinsky, Sascha N Goonewardena
The surface properties of nanoparticles (NPs) are a major factor that influences how these nanomaterials interact with biological systems. Interactions between NPs and macrophages of the reticuloendothelial system (RES) can reduce the efficacy of NP diagnostics and therapeutics. Traditionally, to limit NP clearance by the RES system, the NP surface is neutralized with molecules like poly(ethylene glycol) (PEG) which are known to resist protein adsorption and RES clearance. Unfortunately, PEG modification is not without drawbacks including difficulties with the synthesis and associations with immune reactions...
June 30, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28702658/overcoming-multidrug-resistance-using-folate-receptor-targeted-and-ph-responsive-polymeric-nanogels-containing-covalently-entrapped-doxorubicin
#10
Y Chen, O Tezcan, D Li, N Beztsinna, B Lou, T Etrych, K Ulbrich, J M Metselaar, T Lammers, W E Hennink
Multidrug resistance (MDR) contributes to failure of chemotherapy. We here show that biodegradable polymeric nanogels are able to overcome MDR via folic acid targeting. The nanogels are based on hydroxyethyl methacrylamide-oligoglycolates-derivatized poly(hydroxyethyl methacrylamide-co-N-(2-azidoethyl)methacrylamide) (p(HEMAm-co-AzEMAm)-Gly-HEMAm), covalently loaded with the chemotherapeutic drug doxorubicin (DOX) and subsequently decorated with a folic acid-PEG conjugate via copper-free click chemistry. pH-Responsive drug release is achieved via the acid-labile hydrazone bond between DOX and the methacrylamide polymeric network...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28700822/laser-desorption-postionization-mass-spectrometry-imaging-of-folic-acid-molecules-in-tumor-tissue
#11
Qiao Lu, Yongjun Hu, Jiaxin Chen, Shan Jin
Mass spectrometry imaging (MSI) is an innovative and powerful tool in biomedical research. It is well known that folic acid (FA) has a high affinity for folic acid receptor (FR) which is overexpressing in epithelial cancer. Herein, we propose a novel method to diagnose cancer through direct mapping of the label-free FA spatial distribution in tissue sections by state-of-the-art laser desorption postionization mass spectrometry imaging (LDPI-MSI). Compared with other tumor imaging methods, such as fluorescence imaging, photoacoustic imaging (PAI), magnetic resonance imaging (MRI) and micro-SPECT/CT, complicated synthesis and labeling processes are not required...
July 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28698916/maternal-supplementation-with-small-quantity-lipid-based-nutrient-supplements-during-pregnancy-and-lactation-does-not-reduce-depressive-symptoms-at-6%C3%A2-months-postpartum-in-ghanaian-women-a-randomized-controlled-trial
#12
Harriet Okronipa, Seth Adu-Afarwuah, Anna Lartey, Per Ashorn, Stephen A Vosti, Rebecca R Young, Kathryn G Dewey
We examined the impact on depression at 6 months postpartum of maternal supplementation with small-quantity lipid-based nutrient supplement (SQ-LNS) compared to supplementation with iron and folic acid (IFA) or multiple micronutrients (MMN). In this partially double-blinded randomized controlled trial, pregnant women ≤20 weeks gestation (n = 1320) were recruited from antenatal clinics and randomly assigned to receive either (1) SQ-LNS during pregnancy and for 6 months postpartum, or (2) IFA during pregnancy only, or (3) MMN during pregnancy and for 6 months postpartum...
July 11, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28697225/low-dose-methotrexate-for-vitiligo
#13
Anna Cristina Garza-Mayers, Daniela Kroshinsky
<p>BACKGROUND: Treatment of vitiligo is aimed at repigmentation and often consists of multiple modalities, none of which are universally or rapidly successful. Extensive cases are most often treated with ultraviolet light therapy, which can be both costly and time-consuming. Though vitiligo is an autoimmune disease, there is no current data to support systemic immunosuppressive monotherapy.</p> <p>CASE SUMMARY: Here we present a case series of 3 patients with vitiligo treated for 11-16 months with low-dose methotrexate (12...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28692689/factors-influencing-maternal-nutrition-practices-in-a-large-scale-maternal-newborn-and-child-health-program-in-bangladesh
#14
Phuong H Nguyen, Tina Sanghvi, Sunny S Kim, Lan M Tran, Kaosar Afsana, Zeba Mahmud, Bachera Aktar, Purnima Menon
Improving maternal nutrition practices during pregnancy is essential to save lives and improve health outcomes for both mothers and babies. This paper examines the maternal, household, and health service factors influencing maternal nutrition practices in the context of a large scale maternal, newborn, and child health (MNCH) program in Bangladesh. Data were from a household survey of pregnant (n = 600) and recently delivered women (n = 2,000). Multivariate linear and logistic regression analyses were used to examine the determinants of three outcomes: consumption of iron and folic acid (IFA) tablets, calcium tablets, and diverse diets...
2017: PloS One
https://www.readbyqxmd.com/read/28689805/the-importance-of-folate-vitamins-b6-and-b12-for-the-lowering-of-homocysteine-concentrations-for-patients-with-recurrent-pregnancy-loss-and-mthfr-mutations
#15
Danielius Serapinas, Evelina Boreikaite, Agne Bartkeviciute, Rita Bandzeviciene, Mindaugas Silkunas, Daiva Bartkeviciene
In patients with MTHFR (methylenetetrahydrofolate reductase) mutations and hyperhomocysteinemia, recurrent pregnancy loss is a frequent feature. The aim of the study was to evaluate the impact of folic acid, vitamins B6 and B12 supplementation for the lowering of total homocysteine concentrations and pregnancy. 16 patients who had had 3 or more miscarriages and MTHFR mutations were used in the study. They received methylfolate (5mg/day), vitamin B6 (50mg/day) and vitamin B12 (1mg/week). Supplementation induced a decrease in homocysteine from 19...
July 6, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28685231/hybrid-polymeric-protein-nano-carriers-hppnc-for-targeted-delivery-of-tgf%C3%AE-inhibitors-to-hepatocellular-carcinoma-cells
#16
Nemany A N Hanafy, Alessandra Quarta, Riccardo Di Corato, Luciana Dini, Concetta Nobile, Vittorianna Tasco, Sonia Carallo, Mariafrancesca Cascione, Andrea Malfettone, Jitka Soukupova, Rosaria Rinaldi, Isabel Fabregat, Stefano Leporatti
TGFβ1 pathway antagonists have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Inhibiting peptides, as P-17 in this study, are bound to either TGFβ1 or its receptors, blocking signal transduction. However, for efficient use of these TGFβ1antagonist as target therapeutic tools, improvement in their delivery is required. Here, a plasmid carrying specific shDNA (SHT-DNA), small interfering RNA (siRNA), and the peptide (P-17) were loaded separately into folic acid (FA)-functionalized nano-carriers made of Bovine Serum Albumin (BSA)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28685068/protein-and-mrna-expression-of-folic-acid-associated-enzymes-as-biomarkers-for-the-cytotoxicity-of-the-thymidylate-synthase-targeted-drugs-pemetrexed-and-s-1-in-non-small-cell-lung-cancer
#17
Madoka Kimura, Fumio Imamura, Takako Inoue, Kazumi Nishino, Junji Uchida, Toru Kumagai, Jiro Okami, Masahiko Higasiyama, Shingo Kamoshida
The thymidylate synthase (TS)-targeted drugs, pemetrexed and S-1, exert an important role in advanced non-small cell lung cancer (NSCLC) treatment; folic acid-associated enzymes are expected to behave as biomarkers, although their role has yet to be fully elucidated. In the present study, a single-institutional prospective analysis, in which the mRNA and protein expression levels of five folic acid-associated enzymes were evaluated with surgical specimens of NSCLC, was performed. Drug sensitivity was evaluated using a collagen gel droplet-embedded culture drug sensitivity test (CD-DST) in vitro...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28682891/influence-of-phenylketonuria-s-diet-on-dimethylated-arginines-and-methylation-cycle
#18
Fernando Andrade, Olalla López-Suárez, Marta Llarena, María L Couce, Luis Aldámiz-Echevarría
Phenylketonuria's (PKU) treatment based on low natural protein diet may affect homocysteine (Hcys) metabolic pathway. Hcys alteration may be related to the methylation of arginine to asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), which both modify nitric oxide production. The aim of this work is to evaluate the status of Hcys formation methylation cycle and ADMA and SDMA levels in patients with PKU in order to establish a potential relationship.Forty-two early diagnosed PKU patients under dietary treatment and good adherence to their diets were enrolled in this cross-sectional study...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28682588/an-efficient-hydrogen-generation-cuo-co3o4-heterojunction-nanofibers-for-sensitive-detection-of-cancer-cells-by-portable-pressure-meter
#19
Erli Ding, Jun Hai, Tianrong Li, Jie Wu, Fengjuan Chen, Yin Wen, Baodui Wang, Xiaoquan Lu
Portable, low-cost, and quantitative detection of cancer cells at home and in the field has the potential to revolutionize medical diagnostics. We first report the design and synthesis of highly efficient folic acid-conjugated hydrogen-generation tube-in-tube CuO/Co3O4 heterojunction nanofibers for highly sensitive and rapidly recognition of cancer cells through pressure signal under visible light irradiation. The resultant nanofibers can dramatically enhance the hydrogen-generation activity of ammonia borane under visible light irradiation...
July 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28681330/antiproliferative-activity-and-vegf-expression-reduction-in-mcf7-and-pc-3-cancer-cells-by-paclitaxel-and-imatinib-co-encapsulation-in-folate-targeted-liposomes
#20
Marco Júnio Peres-Filho, Alexandre Pereira Dos Santos, Thais Leite Nascimento, Renato Ivan de Ávila, Fabrícia Saba Ferreira, Marize Campos Valadares, Eliana Martins Lima
Co-encapsulation of anticancer drugs paclitaxel and imatinib in nanocarriers is a promising strategy to optimize cancer treatment. Aiming to combine the cytotoxic and antiangiogenic properties of the drugs, a liposome formulation targeted to folate receptor co-encapsulating paclitaxel and imatinib was designed in this work. An efficient method was optimized for the synthesis of the lipid anchor DSPE-PEG(2000)-folic acid (FA). The structure of the obtained product was confirmed by RMN, FT-IR, and ESI-MS techniques...
July 5, 2017: AAPS PharmSciTech
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