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https://www.readbyqxmd.com/read/29029337/protective-effect-of-indoor-residual-spraying-of-insecticide-on-preterm-birth-among-pregnant-women-with-hiv-in-uganda-a-secondary-data-analysis
#1
Michelle E Roh, Stephen Shiboski, Paul Natureeba, Abel Kakuru, Mary Muhindo, Teddy Ochieng, Albert Plenty, Catherine A Koss, Tamara D Clark, Patricia Awori, Miriam Nakalambe, Deborah Cohan, Prasanna Jagannathan, Roly Gosling, Diane V Havlir, Moses R Kamya, Grant Dorsey
Background: Recent evidence demonstrated improved birth outcomes among HIV-uninfected pregnant women protected by indoor residual spraying of insecticide (IRS). Evidence regarding its impact on HIV-infected pregnant women is lacking. Methods: Data were pooled from two studies conducted before-and-after an IRS campaign in Tororo, Uganda among HIV-infected pregnant women who received bednets, daily trimethoprim-sulfamethoxazole (TMP-SMX), and combination antiretroviral therapy (c-ART) at enrollment...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029135/small-increase-in-dolutegravir-trough-but-equivalent-total-dolutegravir-exposure-with-simeprevir-in-hiv-hcv-seronegative-volunteers
#2
Christine E MacBrayne, Jose Castillo-Mancilla, James R Burton, Samantha MaWhinney, Charlotte B Wagner, Kestutis Micke, Jordan Fey, Ryan T Huntley, Bayli Larson, Lane R Bushman, Jennifer J Kiser
Background: Dolutegravir, an HIV integrase strand-transfer inhibitor, and simeprevir, an HCV NS3/4A PI, have the potential to interact as dolutegravir is a P-glycoprotein, uridine glucuronosyl transferase 1A1 and cytochrome P450 3A substrate and simeprevir has been shown to mildly inhibit these. Objectives: To compare dolutegravir and simeprevir pharmacokinetics (PK) when given separately versus in combination. Methods: Healthy volunteers received: (i) 150 mg of simeprevir once daily for 7 days; (ii) 50 mg of dolutegravir once daily for 7 days; and (iii) 150 mg of simeprevir once daily plus 50 mg of dolutegravir once daily for 7 days, with randomization to treatment sequence...
October 4, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29028664/abacavir-use-and-risk-of-recurrent-myocardial-infarction-the-d-a-d-study
#3
Caroline A Sabin, Lene Ryom, Antonella d'Arminio Monforte, Camilla I Hatleberg, Christian Pradier, Wafaa El-Sadr, Ole Kirk, Rainer Weber, Andrew N Phillips, Amanda Mocroft, Fabrice Bonnet, Matthew Law, Stephane de Wit, Peter Reiss, Jens D Lundgren
OBJECTIVE: To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI. DESIGN: International multi-cohort collaboration with follow-up from 1999-2016. METHODS: The rate of recurrent MI was described among D:A:D participants who experienced an index MI whilst in the study, and who remained under follow-up beyond 28 days after this MI. Follow-up was considered to the date of next MI, death, 01/Feb/2016 or 6 months after last clinic visit...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29028660/cumulative-exposure-of-tenofovir-disoproxil-fumarate-is-associated-with-kidney-tubulopathy-whether-it-is-currently-used-or-discontinued-in-hiv-infected-patients
#4
Takeshi Nishijima, Yoshikazu Mutoh, Yohei Kawasaki, Kiyomi Tomonari, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
OBJECTIVE: TDF increases the risk of kidney tubular dysfunction (KTD). This study was conducted to elucidate whether KTD persists after discontinuation of TDF. DESIGN: A prospective cross-sectional study which enrolled 941 HIV-1-infected patients. METHODS: KTD was predefined as the presence of at least two abnormalities among the five tubular markers (fractional excretion of phosphate, fractional excretion of uric acid, β2-microglobulinuria, N-acetyl-β-D-glucosaminidase, non-diabetic glycosuria)...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29028656/costs-and-benefits-of-on-demand-hiv-pre-exposure-prophylaxis-in-men-who-have-sex-with-men-analysis-of-the-anrs-ipergay-study-with-a-one-year-follow-up
#5
Isabelle Durand-Zaleski, Pierre Mutuon, Isabelle Charreau, Cecile Tremblay, Daniela Rojas, Gilles Pialoux, Christian Chidiac, Catherine Capitant, Bruno Spire, Laurent Cotte, Julie Chas, Laurence Meyer
OBJECTIVES: We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial which showed the efficacy of on-demand pre-exposure prophylaxis (PrEP) with tenofovir-disoproxil-fumarate (TDF-FTC) in preventing HIV infection among high risk men-who have-sex-with-men (MSM). DESIGN & METHODS: The economic evaluation was prospective. Counseling, drugs (TDF-FTC at &OV0556;500.88 for 30 tablets), tests, visits and hospital admissions were valued based on in-trial use...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29028125/ledipasvir-and-tenofovir-drug-interaction-in-hiv-hcv-co-infected-patients-impact-on-tenofovir-ctrough-and-renal-safety
#6
Caroline Solas, Sylvie Bregigeon, Olivia Faucher-Zaegel, Sylvie Quaranta, Véronique Obry-Roguet, Catherine Tamalet, Bruno Lacarelle, Isabelle Poizot-Martin
We evaluate the impact of ledipasvir on both tenofovir plasma trough concentration (Ctrough ) and estimated glomerular renal function (eGFR) in HIV-HCV co-infected patients receiving a tenofovir(TDF)-based antiretroviral regimen and treated with ledipasvir/sofosbuvir. Twenty-six patients [81% male, median age: 51years; HCV genotype 1(75%)/4(15%)] were included. Tenofovir Ctrough (interquartile:IQR) increased from 78ng/mL (53-110) at baseline to 141ng/mL (72-176) at M1 (p=0.003). No significant difference on eGFR using both Cockroft-Gault and MDRD formula, respectively [median(IQR)] was observed between baseline [101...
October 13, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29027392/summary-of-guidelines-for-the-use-of-pre-exposure-prophylaxis-for-hiv-in-korea
#7
REVIEW
(no author information available yet)
There are several guidelines for the use of pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) which are used in other countries. However, the implementation of such guidelines in each country should be modified according to the country's clinical and epidemiological situation. Therefore, The Korean Society for AIDS founded a committee in 2016 to develop guidelines for the use of PrEP for HIV that are optimal for Korea's clinical and epidemiological situation. These guidelines aim to provide comprehensive information for PrEP implementation in Korea...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29026872/top-questions-in-id-pre-exposure-prophylaxis-for-hiv
#8
Douglas S Krakower, Stephanie E Cohen, Kenneth H Mayer
HIV pre-exposure prophylaxis (PrEP) is highly efficacious at preventing HIV acquisition. This review discusses ways to identify candidates for PrEP, recommended PrEP regimens, baseline and follow-up evaluations, applications of PrEP for HIV-serodiscordant couples, resources to address financial barriers, investigational strategies for PrEP, and educational resources for clinicians and patients.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29026869/associations-between-antiretroviral-treatment-and-avascular-bone-necrosis-the-swiss-hiv-cohort-study
#9
Cornelia Bayard, Bruno Ledergerber, Markus Flepp, Thanh Lecompte, Estelle Moulin, Matthias Hoffmann, Rainer Weber, Cornelia Staehelin, Caroline Di Benedetto, Christoph A Fux, Philip E Tarr, Barbara Hasse
BACKGROUND: HIV-infected individuals have an increased risk of avascular bone necrosis (AVN). Antiretroviral therapy (ART) and particularly protease inhibitors (PI) have been implicated as a risk factor. We aimed to study the associations of ART with the occurrence of AVN among Swiss HIV Cohort Study participants (SHCS). METHODS: We used incidence density sampling to perform a case control study within the Swiss HIV Cohort Study (SHCS) comparing prospectively collected AVN cases and controls by conditional logistic regression analysis...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29025633/association-between-male-circumcision-and-women-s-biomedical-health-outcomes-a-systematic-review
#10
Jonathan M Grund, Tyler S Bryant, Inimfon Jackson, Kelly Curran, Naomi Bock, Carlos Toledo, Joanna Taliano, Sheng Zhou, Jorge Martin Del Campo, Ling Yang, Apollo Kivumbi, Peizi Li, Sherri Pals, Stephanie M Davis
BACKGROUND: Male circumcision reduces men's risk of acquiring HIV and some sexually transmitted infections from heterosexual exposure, and is essential for HIV prevention in sub-Saharan Africa. Studies have also investigated associations between male circumcision and risk of acquisition of HIV and sexually transmitted infections in women. We aimed to review all evidence on associations between male circumcision and women's health outcomes to benefit women's health programmes. METHODS: In this systematic review we searched for peer-reviewed and grey literature publications reporting associations between male circumcision and women's health outcomes up to April 11, 2016...
November 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29025480/correlates-of-observing-and-willingness-to-report-stigma-towards-hiv-clients-by-tb-health-workers-in-africa
#11
M Straetemans, M I Bakker, E M H Mitchell
SETTING: Health care facilities in Kenya, Tanzania and Namibia. OBJECTIVE: To study the factors associated with the observation of and willingness to report stigmatising behaviour towards persons living with the human immunodeficiency virus (HIV) among health care workers (HCWs). DESIGN: Mixed-effect logistic regression analyses of 9516 HCW interviews, including those of 4062 (43%) TB workers carried out as part of the Service Provision Assessments (SPAs) between 2006 and 2010...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29023357/pharmacokinetics-safety-and-efficacy-of-maraviroc-in-treatment-experienced-pediatric-patients-infected-with-ccr5-tropic-hiv-1
#12
Carlo Giaquinto, Muthuhadini Patience Mawela, Kulkanya Chokephaibulkit, Marinella Della Negra, Ismail Haroon Mitha, Jan Fourie, Annie Fang, Elna van der Ryst, Srinivas Rao Valluri, Manoli Vourvahis, Rebecca Yanhui Zhang-Roper, Charles Craig, Lynn McFadyen, Andrew Clark, Jayvant Heera
BACKGROUND: Maraviroc is a CCR5 antagonist approved to treat adults infected with CCR5-tropic (R5) HIV-1. Study A4001031 was conducted to evaluate the pharmacokinetics, safety, and efficacy of maraviroc in combination with optimized background therapy (OBT) in treatment-experienced pediatric patients infected with R5 HIV-1 and support registration of maraviroc for pediatric use. METHODS: This is an open-label, 2-stage, age-stratified, non-comparative multicenter study...
October 7, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29023252/partner-notification-for-youth-living-with-hiv-in-14-cities-in-the-united-states
#13
Jacob J van den Berg, Marjan Javanbakht, Pamina M Gorbach, Bret J Rudy, Andrew O Westfall, Craig M Wilson, Michelle A Lally
BACKGROUND: Identifying factors associated with partner notification among youth living with HIV is critical for effective HIV prevention and treatment strategies. METHODS: A total of 924 male and female behaviorally-infected youth ages 13-24 across 14 U.S. cities completed an audio-computer assisted self-interview including questions about demographics and experiences with patient- and provider-referral partner notification. RESULTS: The majority of participants self-identified as male (82...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29023141/sexual-identity-disclosure-and-awareness-of-hiv-prevention-methods-among-black-men-who-have-sex-with-men
#14
Ryan J Watson, Jessica N Fish, Aerielle Allen, Lisa Eaton
Black men who have sex with men (BMSM) are disproportionately affected by the human immunodeficiency virus (HIV) epidemic, yet we know little about how HIV-negative BMSM of different sexual orientations access HIV prevention strategies. Identity development, minority stress, and disclosure theories suggest that for people of different sexual orientations, disclosure of sexual identity may be related to health behaviors. We performed a latent class analysis on a sample of 650 BMSM (Mage = 33.78, SD = 11...
October 12, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29022569/syphilis
#15
REVIEW
Rosanna W Peeling, David Mabey, Mary L Kamb, Xiang-Sheng Chen, Justin D Radolf, Adele S Benzaken
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. T. pallidum is renowned for its invasiveness and immune-evasiveness; its clinical manifestations result from local inflammatory responses to replicating spirochaetes and often imitate those of other diseases. The spirochaete has a long latent period during which individuals have no signs or symptoms but can remain infectious. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries...
October 12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29021643/cryptococcal-cerebellitis-in-no-vih-patient
#16
Fabricio Andres Lasso, Tomas Omar Zamora Bastidas, Jorge Andrés Potosí García, Bairon Díaz Idrobo
INTRODUCTION: Cryptococcosis is an opportunistic fungal infection whose etiology is Cryptococcus neofromans / C. gattii, complex which affects immunocompromised patients mainly. Meningeal infection is one of the most common presentations, but cerebellar affection is rare. CASE DESCRIPTION: Male patient with 65 old years, from an area of subtropical climate with chronic exposure to poultry, without pathological antecedents, who presented clinical picture consistent with headache, fever, seizures and altered mental status...
June 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29021399/modelling-of-anti-latency-treatment-in-hiv-what-is-the-optimal-duration-of-anti-retroviral-free-hiv-remission
#17
Deborah Cromer, Mykola Pinkevych, Thomas A Rasmussen, Sharon R Lewin, Stephen J Kent, Miles P Davenport
A number of treatment strategies are currently being developed to promote anti-retroviral free HIV cure or remission. While complete elimination of the HIV reservoir would prevent recurrence of infection, it is not clear how different remission lengths would affect viral rebound and transmission. In this work we use a stochastic model to show that a treatment that achieves a one-year average time to viral remission will still lead to nearly a quarter of subjects experiencing viral rebound within the first three months...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29021079/blood-borne-virus-transmission-in-an-urban-culturally-diverse-neighbourhood-results-from-a-cross-sectional-bio-behavioural-survey-using-innovative-outreach-methods-in-a-hard-to-reach-population
#18
Elizabeth Peach, Shelley Cogger, Kat Byron, Penny Francis, Daniel O'Keefe, Peter Higgs, Mark Stoove, Kasey Elmore, Paul Dietze, Margaret Hellard
Background: Following a HIV outbreak among Aboriginal people in a culturally diverse inner-city suburb of Melbourne, a blood-borne virus (BBV) screening program was conducted to inform public health interventions to prevent transmission and facilitate timely diagnosis and linkage to care. Methods: In August-September 2014, community health workers recruited people who inject drugs (PWID) from a local needle and syringe program. Participants were tested for hepatitis C virus (HCV), hepatitis B virus (HBV), HIV and syphilis and completed a bio-behavioural questionnaire...
October 12, 2017: Sexual Health
https://www.readbyqxmd.com/read/29020335/hiv-drug-resistance-in-african-infants-and-young-children-newly-diagnosed-with-hiv-a-multicounty-analysis
#19
Michael R Jordan, Martina Penazzato, Amandine Cournil, Adolfo Vubil, Ilesh Jani, Gillian Hunt, Sergio Carmona, Gugu Maphalala, Nobuhle Mthethwa, Christine Watera, Pontiano Kaleebu, Christine Chakanyuka Musanhu, Sekesai Mtapuri-Zinyowera, Janet Dzangare, Martine Peeters, Chunfu Yang, Neil Parkin, Silvia Bertagnolio
Background: Prevention of mother-to-child transmission (PMTCT) of HIV programs have been scaled-up in many low- and middle-income countries; however, HIV drug resistance (HIVDR) data amongst HIV-1-infected young children remain limited. Methods: Surveys of pre-treatment HIVDR amongst children younger than 18 months of age who were diagnosed with HIV through Early Infant Diagnosis were conducted in five sub-Saharan African countries (Mozambique, Swaziland, South Africa, Uganda, and Zimbabwe) between 2011 and 2014 following World Health Organization guidance...
August 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020282/elevated-levels-of-estradiol-in-hiv-positive-pregnant-women-on-protease-inhibitor-based-regimens
#20
Kayode A Balogun, Monica Guzman Lenis, Eszter Papp, Mona Loutfy, Mark H Yudin, Jay MacGillivray, Sharon L Walmsley, Michael Silverman, Lena Serghides
Background: HIV-positive pregnant women on protease inhibitor (PI)-based combination antiretroviral therapy (cART) have a greater risk for adverse birth outcomes, and an association with steroid hormone levels has been implicated. The objective of this study was to investigate the association between PI-cART and estradiol levels in pregnancy. Methods: Fifty-five HIV-positive and 49 HIV-negative Canadian pregnant women were followed prospectively throughout gestation...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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