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https://www.readbyqxmd.com/read/29232276/contemporary-protease-inhibitors-and-cardiovascular-risk
#1
Jens Lundgren, Amanda Mocroft, Lene Ryom
PURPOSE OF REVIEW: To review the evidence linking use of HIV protease inhibitors with excess risk of cardiovascular disease (CVD) in HIV+ populations. RECENT FINDINGS: For the two contemporary most frequently used protease inhibitors, darunavir and atazanavir [both pharmacologically boosted with ritonavir (/r)], darunavir/r has been shown to be associated with increased CVD risk. The effect is cumulative with longer exposure increasing risk and an effect size comparable to what has been observed for previously developed protease inhibitors...
December 9, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29232170/correlates-of-never-testing-for-hiv-among-sexually-active-internet-recruited-gay-bisexual-and-other-men-who-have-sex-with-men-in-the-united-states
#2
Kimberly M Nelson, David W Pantalone, Kristi E Gamarel, Michael P Carey, Jane M Simoni
In the United States, gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by the HIV/AIDS epidemic. Despite great strides in HIV prevention, including biobehavioral HIV prevention strategies such as pre-exposure prophylaxis and treatment as prevention, there has been relatively low uptake of these strategies. The success of biobehavioral prevention strategies requires HIV testing but a subset of GBMSM have never been tested. To optimize prevention efforts, we sought to understand the characteristics of GBMSM who report never testing for HIV...
December 12, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29229609/recent-advances-in-pre-exposure-prophylaxis-for-hiv
#3
REVIEW
Monica Desai, Nigel Field, Robert Grant, Sheena McCormack
Although pre-exposure prophylaxis (PrEP)-the use of antiretroviral drugs by non-infected people to prevent the acquisition of HIV-is a promising preventive option, important public health questions remain. Daily oral emtricitabine (FTC)-tenofovir disoproxil fumarate (TDF) is highly efficacious in preventing the acquisition of HIV in people at risk as a result of a range of different types of sexual exposure. There is good evidence of efficacy in women and men, and when men who have sex with men use event based dosing...
December 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29229440/post-exposure-prophylaxis-with-doxycycline-to-prevent-sexually-transmitted-infections-in-men-who-have-sex-with-men-an-open-label-randomised-substudy-of-the-anrs-ipergay-trial
#4
Jean-Michel Molina, Isabelle Charreau, Christian Chidiac, Gilles Pialoux, Eric Cua, Constance Delaugerre, Catherine Capitant, Daniela Rojas-Castro, Julien Fonsart, Béatrice Bercot, Cécile Bébéar, Laurent Cotte, Olivier Robineau, François Raffi, Pierre Charbonneau, Alexandre Aslan, Julie Chas, Laurence Niedbalski, Bruno Spire, Luis Sagaon-Teyssier, Diane Carette, Soizic Le Mestre, Veronique Doré, Laurence Meyer
BACKGROUND: Increased rates of sexually transmitted infections (STIs) have been reported among men who have sex with men. We aimed to assess whether post-exposure prophylaxis (PEP) with doxycycline could reduce the incidence of STIs. METHODS: All participants attending their scheduled visit in the open-label extension of the ANRS IPERGAY trial in France (men aged 18 years or older having condomless sex with men and using pre-exposure prophylaxis for HIV with tenofovir disoproxil fumarate plus emtricitabine) were eligible for inclusion in this open-label randomised study...
December 8, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29228317/leukocyte-telomere-length-at-birth-and-during-the-early-life-of-hiv-exposed-uninfected-children-following-in-utero-exposure-to-antiretrovirals
#5
Abhinav Ajaykumar, Hugo Soudeyns, Fatima Kakkar, Jason Brophy, Ari Bitnun, Ariane Alimenti, Arianne Y K Albert, Deborah M Money, Hélène C F Côté
Background: Maternal combination antiretroviral therapy (cART) during pregnancy could impact the health of HIV-exposed uninfected (HEU) children, as some antiretrovirals cross the placenta and can inhibit telomerase. Our objective was to compare HEU and HIV-unexposed uninfected (HUU) leukocyte telomere length (LTL) at birth and in early life, and investigate any relationship with cART exposure. Methods: HEU and HUU children's blood LTL was compared cross-sectionally at birth, and during the first three years of life...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29228144/randomized-controlled-trial-of-daily-text-messages-to-support-adherence-to-prep-in-at-risk-for-hiv-individuals-the-tapir-study
#6
David J Moore, Sonia Jain, Michael P Dubé, Eric S Daar, Xiaoying Sun, Jason Young, Katya Corado, Eric Ellorin, Joel Milam, Deborah Collins, Jill Blumenthal, Brookie M Best, Peter Anderson, Richard Haubrich, Sheldon R Morris
Background: Adherence is critical for efficacy of tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis (PrEP). Methods: Between 02/2013 and 02/2016, 398 men who have sex with men and transgender women were randomized 1:1 to receive individualized Texting for Adherence Building (iTAB) or standard care (SoC) for 48 weeks. The primary endpoint was dried blood spot (DBS) tenofovir (TFV-DP) concentrations at both week 12 and week 48 (or the last on-drug visit) of >719 fmol/punch consistent with ≥4 doses per week (i...
November 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29227461/population-pharmacokinetics-of-lopinavir-in-severely-malnourished-hiv-infected-children-and-the-effect-on-treatment-outcomes
#7
Moherndran Archary, Helen Mcllleron, Raziya Bobat, Phillip La Russa, Thobekile Sibaya, Lubbe Wiesner, Stefanie Hennig
BACKGROUND: In developing countries, malnutrition remains a common clinical syndrome at antiretroviral treatment (ART) initiation. Physiological changes due to malnutrition and during nutritional recovery could affect the pharmacokinetics of antiretroviral drugs. METHODS: HIV-infected children admitted with severe acute malnutrition were randomised to early or delayed initiation of lopinavir/ritonavir, abacavir and lamivudine using WHO weight-band dosage charts...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29225896/incidence-of-diabetes-mellitus-and-factors-associated-with-its-development-in-hiv-positive-patients-over-the-age-of-50
#8
Faizal Samad, Marianne Harris, Cathy M Puskas, Monica Ye, Jason Chia, Sarah Chacko, Gregory P Bondy, Viviane D Lima, Julio Sg Montaner, Silvia A Guillemi
Objective: We sought to determine the incidence and factors associated with development of diabetes mellitus (DM) in older HIV-infected individuals. Research design and methods: We analyzed data from people living with HIV (PLWH) ≥50 years of age enrolled in a large urban HIV outpatient clinic in Vancouver, British Columbia. Patients were categorized as having DM if they had random blood sugar ≥11.1 mmol/L, fasting blood sugar ≥7 mmol/L, HbA1C ≥6.5%, antidiabetic medication use during the follow-up period, or medical chart review confirming diagnosis of DM...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29224988/linking-hiv-negative-youth-to-prevention-services-in-12-u-s-cities-barriers-and-facilitators-to-implementing-the-hiv-prevention-continuum
#9
Mimi Doll, J Dennis Fortenberry, Denise Roseland, Kathleen McAuliff, Craig M Wilson, Cherrie B Boyer
PURPOSE: Linkage of HIV-negative youth to prevention services is increasingly important with the development of effective pre-exposure prophylaxis that complements behavioral and other prevention-focused interventions. However, effective infrastructure for delivery of prevention services does not exist, leaving many programs to address HIV prevention without data to guide program development/implementation. The objective of this study was to provide a qualitative description of barriers and facilitators of linkage to prevention services among high-risk, HIV-negative youth...
December 7, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29214409/strategies-to-implement-pre-exposure-prophylaxis-with-men-who-have-sex-with-men-in-ukraine
#10
Alex Dubov, Liana Fraenkel, Roman Yorick, Adedotun Ogunbajo, Frederick L Altice
Ukrainian men who have sex with men (MSM) remain highly stigmatized group with HIV prevalence as high as 23%. Despite documented effectiveness of pre-exposure prophylaxis (PrEP), PrEP remains unavailable in Ukraine. The aim of this study was to elicit MSM preferences in order to inform program development to facilitate successful delivery of PrEP to Ukrainian MSM. 1184 MSM were recruited through social networking applications to complete a stated preference (choice-based conjoint) survey. Respondents completed 14 choice tasks presenting experimentally-varied combinations of five attributes related to PrEP administration (dosing frequency, dispensing venue, prescription practices, adherence support, and costs)...
December 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29211835/massive-iatrogenic-outbreak-of-human-immunodeficiency-virus-type-1-in-rural-cambodia-2014-2015
#11
François Rouet, Janin Nouhin, Du-Ping Zheng, Benjamin Roche, Allison Black, Sophearot Prak, Marie Leoz, Catherine Gaudy-Graffin, Laurent Ferradini, Chandara Mom, Sovatha Mam, Charlotte Gautier, Gérard Lesage, Sreymom Ken, Kerya Phon, Alexandra Kerleguer, Chunfu Yang, William Killam, Masami Fujita, Chhivun Mean, Didier Fontenille, Francis Barin, Jean-Christophe Plantier, Trevor Bedford, Artur Ramos, Vonthanak Saphonn
Background: In 2014-2015, 242 individuals aged 2-89 were newly HIV-1 diagnosed in Roka, a rural commune in Cambodia. A case-control study attributed the outbreak to unsafe injections. We aimed to reconstruct the likely transmission history of the outbreak. Methods: We assessed in 209 (86.4%) HIV-infected cases the presence of hepatitis C and B viruses (HCV, HBV). We identified recent infections using antibody (Ab) avidity testing for HIV and HCV, and HBcIgM Ab for HBV...
December 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29211633/prevalence-and-patterns-of-victimization-and-polyvictimization-among-female-sex-workers-in-soweto-a-south-african-township-a-cross-sectional-respondent-driven-sampling-study
#12
J Coetzee, G E Gray, R Jewkes
BACKGROUND: Female sex workers (FSWs) are disproportionately affected by violence from multiple partner categories. This increases their vulnerability to HIV. OBJECTIVES: To describe patterns of violence and polyvictimization among female SWs in Soweto. METHODS: A respondent-driven sampling (RDS) recruitment methodology was used to enrol 508 Soweto-based FSWs using a survey instrument. Raw and RDS adjusted data were descriptively analysed, Spearman's correlation and chi2 test of association were used to show associations...
2017: Global Health Action
https://www.readbyqxmd.com/read/29211515/factors-associated-with-use-of-short-term-pre-exposure-prophylaxis-for-hiv-among-female-partners-of-migrant-miners-in-mozambique
#13
Joana Falcao, Allison Zerbe, Maria Lahuerta, Rachel Baggaley, Laurence Ahoua, Pietro DiMattei, Fernando Morales, Isaias Ramiro, Wafaa M El-Sadr
Effective interventions tailored to specific types of behaviors and contexts are needed for women at risk for HIV acquisition. Oral pre-exposure prophylaxis (PrEP) is an efficacious HIV prevention intervention that uses antiretroviral drugs to reduce the risk of acquiring HIV infection. In Mozambique, HIV remains a major public health concern, with a national prevalence of 13%. Studies have demonstrated that the migration of male miners between southern provinces of Mozambique and South Africa is contributing to the HIV epidemic in Mozambique...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211514/hiv-care-providers-intentions-to-prescribe-and-actual-prescription-of-pre-exposure-prophylaxis-to-at-risk-adolescents-and-adults
#14
Tanya L Kowalczyk Mullins, Gregory Zimet, Michelle Lally, Jiahong Xu, Sarah Thornton, Jessica A Kahn
Pre-exposure prophylaxis (PrEP) is indicated for use in US adults, and little is known about clinician intentions to prescribe and actual prescription of PrEP to adolescents younger than 18. Fifty-six clinicians who care for HIV-infected and at-risk youth completed an anonymous online survey in 2014. Primary outcomes were (1) intentions to prescribe PrEP to adolescents and adults in four risk categories [men who have sex with men (MSM), transgender women, heterosexuals with multiple partners of unknown HIV status, heterosexuals with HIV-infected partners]; and (2) actual prescription of PrEP to adolescents and adults in these risk groups...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211513/facilitators-and-barriers-to-pre-exposure-prophylaxis-willingness-among-young-men-who-have-sex-with-men-who-use-geosocial-networking-applications-in-california
#15
Ian W Holloway, Diane Tan, Jennifer L Gildner, Sean C Beougher, Craig Pulsipher, Jorge A Montoya, Aaron Plant, Arleen Leibowitz
While correlates of pre-exposure prophylaxis (PrEP) uptake have been explored among older men who have sex with men (MSM), less is known about the facilitators and barriers that encourage uptake among younger MSM (YMSM). This study explores the association between willingness to take PrEP and demographic characteristics, sexual risk, and substance use, and attitudinal factors among YMSM in California who use geosocial networking applications (GSN apps). Based on survey data from YMSM recruited through GSN apps (n = 687), PrEP willingness was positively associated with Hispanic ethnicity [adjusted odds ratio (aOR): 1...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29210835/-medication-adherence-in-a-nationwide-cohort-of-veterans-initiating-pre-exposure-prophylaxis-prep-to-prevent-hiv-infection
#16
Puja van Epps, Marissa Maier, Brian Lund, M Bryant Howren, Brice Beck, Lauren Beste, Avy Skolnik, Mary Vaughan-Sarrazin, Michael E Ohl
BACKGROUND: Current guidelines for pre-exposure prophylaxis (PrEP) to prevent HIV infection call for long-term, daily use of tenofovir disoproxil fumarate / emtricitabine (TDF/FTC). Little is known about long-term adherence with TDF/FTC prescribed for PrEP in routine clinical practice. SETTING: Veterans Health Administration (VHA) clinics METHODS:: We used VHA data to create a nationwide cohort of Veterans initiating PrEP between July 1, 2012 and June 30, 2016. We examined pharmacy refill data to estimate adherence based on the proportion of days covered (PDC) by TDF/FTC in the first year, and used logistic regression to identify patient characteristics associated with high adherence (i...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210834/pre-exposure-prophylaxis-prep-use-and-condomless-anal-sex-evidence-of-risk-compensation-in-a-cohort-of-young-men-who-have-sex-with-men
#17
Michael E Newcomb, Kevin Moran, Brian A Feinstein, Emily Forscher, Brian Mustanski
BACKGROUND: Young men who have sex with men (YMSM) are disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV acquisition. It remains unclear if PrEP use increases rates of condomless sex (i.e., risk compensation), which may increase risk of infection if PrEP adherence is not optimal. This study aimed to examine whether PrEP use and PrEP adherence were associated with change in sexual risk behaviors in a large longitudinal cohort of YMSM reporting on multiple sexual partnerships over time...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210832/quality-of-caregiving-is-positively-associated-with-neurodevelopment-during-the-first-year-of-life-among-hiv-exposed-uninfected-children-in-uganda
#18
Itziar Familiar, Shalean M Collins, Alla Sikorskii, Horacio Ruisenor-Escudero, Barnabas Natamba, Paul Bangirana, Elizabeth M Widen, Daniel Achidri, Harriet Achola, Daniel Onen, Michael Boivin, Sera L Young
OBJECTIVE: We sought to evaluate if maternal characteristics and infant developmental milieu were predictive of early cognitive development in HIV-exposed uninfected (HEU) and un-exposed uninfected (HU) infants in Uganda. DESIGN: Longitudinal pregnancy study. METHODS: Ugandan women (n=228) were enrolled into the Postnatal Nutrition and Psychosocial Health Outcomes (PostNAPS) study with a 2:1 HIV-uninfected:infected ratio. Maternal socio-demographic, perceived social support, and depressive symptomatology were assessed...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210831/correlates-of-linkage-to-hiv-pre-exposure-prophylaxis-prep-among-hiv-testing-clients
#19
Charlene A Flash, Oluwatobi O Adegboyega, Xiaoying Yu, Carmen Avalos, Syundai Johnson, Kenneth H Mayer, Thomas P Giordano
BACKGROUND: Publicly funded HIV testing sites can identify HIV pre-exposure prophylaxis (PrEP) candidates and provide PrEP linkage. SETTING: Harris Health System's HIV clinic, HIV testing program and HIV Prevention Program in Houston, TX, a high HIV incidence city. METHODS: A prospective assessment of individuals ≥18 years old recruited from walk-in HIV testing December, 2013 to April, 2015 included risk assessment, HIV testing and self-administered survey, with follow-up surveys at 6 and 12 months and medical record review...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210777/costs-and-benefits-of-on-demand-hiv-preexposure-prophylaxis-in-msm
#20
Isabelle Durand-Zaleski, Pierre Mutuon, Isabelle Charreau, Cecile Tremblay, Daniela Rojas, Gilles Pialoux, Christian Chidiac, Catherine Capitant, Bruno Spire, Laurent Cotte, Julie Chas, Laurence Meyer, Jean Michel Molina
OBJECTIVES: We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial, which showed the efficacy of on-demand preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-emtricitabine (FTC) in preventing HIV infection among high-risk MSM. DESIGN AND METHODS: The economic evaluation was prospective. Counseling, drugs (TDF-FTC at &OV0556;500.88 for 30 tablets), tests, visits, and hospital admissions were valued based on in-trial use...
January 2, 2018: AIDS
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