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https://www.readbyqxmd.com/read/29772068/risk-factors-associated-with-preterm-delivery-and-low-delivery-weight-among-hiv-exposed-neonates-in-china
#1
Liming Wang, Hongxin Zhao, Weiping Cai, Jie Tao, Qingxia Zhao, Lijun Sun, Qingbo Fan, Athena P Kourtis, Colin Shepard, Fujie Zhang
OBJECTIVE: To examine the relationship between combination antiretroviral therapy (cART) and preterm delivery (PTD) or low delivery weight among pregnant Chinese women with HIV. METHODS: The present retrospective cross-sectional medical chart review enrolled pregnant women with HIV who delivered at five tertiary hospitals in China between January 1, 2009, and December 31, 2014. Generalized linear mixed modeling was used to explore PTD (<37 weeks of pregnancy) and low delivery weight (<2500 g) risk factors...
May 17, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29771868/the-use-of-technology-for-std-partner-services-in-the-united-states-a-structured-review
#2
Rachel Kachur, Wendasha Hall, Alexandra Coor, Jennine Kinsey, Dayne Collins, F V Strona
BACKGROUND: Since the late 1990s, health departments and STD programs throughout the U.S. have used technologies, such as the internet and mobile phones, to provide services to persons with a sexually transmitted infection, including HIV, and their sex partners, also known as partner services. This study reviewed the published literature to assess and compare partner services outcomes as a result of using technology and to calculate cost savings through cases averted. METHODS: We conducted a structured literature review of all U...
May 1, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29771784/zika-virus-exposure-in-an-hiv-infected-cohort-in-ghana
#3
K E Sherman, S D Rouster, L X Kong, T M Shata, T Archampong, A Kwara, M T Aliota, J T Blackard
OBJECTIVE: To determine the prevalence and epidemiologic associations of Zika Virus (ZIKV) in HIV-infected patients in Ghana, West Africa. METHODS: We examined the seroprevalence of ZIKV in HIV/HBV co-infected persons in Ghana from sera samples collected from 2012 to 2014 using ELISA assays and plaque reduction neutralization tests (PRNT). RESULTS: Overall, ZIKV antibody was detected in 12.9% of 236 tested samples, though the true estimate of exposure is probably less due cross-reactions with other related viruses...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771780/biomarkers-of-aging-in-hiv-infected-children-on-suppressive-antiretroviral-therapy
#4
Stephanie Shiau, Renate Strehlau, Jing Shen, Avy Violari, Faeezah Patel, Afaaf Liberty, Marc Foca, Shuang Wang, Mary Beth Terry, Michael T Yin, Ashraf Coovadia, Elaine J Abrams, Stephen M Arpadi, Louise Kuhn
BACKGROUND: Data on accelerated aging in HIV-infected children are limited. In this study we assess two biomarkers of aging - telomere length and DNA methylation (DNAm) age - in a cohort of early-treated HIV-infected children and compare these aging biomarkers to HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children. SETTING: Cross-sectional study of 120 HIV-infected, 33 HEU, and 25 HUU children enrolled in a cohort study in Johannesburg, South Africa...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771378/detection-of-incident-anal-high-risk-hpv-dna-in-msm-incidence-or-reactivation
#5
Denise E Twisk, Marianne A B van der Sande, Arne van Eeden, Daniëlle A M Heideman, Fiona R M van der Klis, Henry J C de Vries, Maarten F Schim van der Loeff
Background: We aimed to assess whether sexual exposure may explain all incident anal HPV detections among men who have sex with men (MSM). Methods: A longitudinal study among MSM was conducted between 2010 and 2013 with six-monthly visits and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by SPF10-PCR/DEIA/LiPA25 system...
May 16, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29768554/prevalence-of-hypoalbuminemia-in-outpatients-with-hiv-aids
#6
José Adalberto Leal, Maria Arlene Fausto, Mariângela Carneiro, Unaí Tubinambás
INTRODUCTION: Hypoalbuminemia may predict progression of disease and mortality in patients with human immunodeficiency virus (HIV) infection/acquired immune deficiency syndrome (AIDS). This study was conducted to investigate the risk factors associated with hypoalbuminemia in outpatients with HIV/AIDS. METHODS: A cross-sectional study was performed in 196 outpatients with HIV/AIDS. RESULTS: The prevalence of hypoalbuminemia was 11.7%. The only risk factor associated with hypoalbuminemia was current antiretroviral therapy (no exposure: odds ratio=3...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29768174/hiv-1-vaccines-based-on-antibody-identification-b-cell-ontogeny-and-epitope-structure
#7
REVIEW
Peter D Kwong, John R Mascola
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion surface. Antibodies isolated from HIV-1-infected donors, however, have been shown to recognize all major exposed regions of the prefusion-closed Env trimer, and an emerging understanding of the immunological and structural characteristics of these antibodies and the epitopes they recognize is enabling new approaches to vaccine design...
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29767640/burden-of-exposure-to-potential-interactions-between-antiretroviral-and-non-antiretroviral-medications-in-a-population-of-hiv-positive-patients-aged-50-years-or-older
#8
Alice Ranzani, Letizia Oreni, Massimiliano Agrò, Lorena van den Bogaart, Laura Milazzo, Andrea Giacomelli, Dario Cattaneo, Cristina Gervasoni, Anna Lisa Ridolfo
BACKGROUND: As HIV-infected patients aged 50 years or older are at increased risk of comorbidities and multidrug treatments, we examined their exposure to the potential drug-drug interactions (PDDIs) of antiretroviral (ARV) and other medications. METHODS: This cross-sectional study involved the patients aged 50 years or older receiving ARV and non-ARV medications at our clinic. PDDIs were identified using the University of Liverpool HIV Drug Interaction Checker...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29764308/balancing-risk-interpersonal-intimacy-and-agency-perspectives-from-marginalised-women-in-zambia
#9
Lwendo Moonzwe Davis, Kristin Marie Kostick
Women are most exposed to sexual health risks within their marital relationships, primarily due to the sexually risky behaviours of their spouses. Studies show that expanding agency is critical for women to mitigate both physical and sexual health risks and is linked to increased psycho-social well-being and economic independence. Drawing on qualitative and quantitative primary data collected from a peri-urban community in Zambia, this paper explores how women exert agency in a community where few educational and economic opportunities and substantial food insecurity exacerbate women's risk for HIV within their marital relationships...
May 15, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29762690/intestinal-integrity-biomarkers-in-early-antiretroviral-treated-perinatally-hiv-1-infected-infants
#10
Wei Li A Koay, Jane C Lindsey, Priyanka Uprety, Mutsa Bwakura-Dangarembizi, Adriana Weinberg, Myron J Levin, Deborah Persaud
Biomarkers of intestinal integrity (intestinal fatty acid binding protein (iFABP) and zonulin), were compared in early antiretroviral-treated, HIV-1-infected (HIV+; n=56) African infants and HIV-exposed but uninfected (HEU; n=53) controls. Despite heightened inflammation and immune activation in HIV+ infants, iFABP and zonulin levels at three months of age were not different from those in HEU infants, and largely not correlated with inflammatory and immune activation biomarkers. However, zonulin levels increased, and became significantly higher in HIV+ compared to HEU infants by five months of age despite ART-suppression...
May 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29762175/pregnancy-outcomes-and-infant-growth-among-babies-with-in-utero-exposure-to-tenofovir-based-pre-exposure-prophylaxis-for-hiv-prevention
#11
Renee Heffron, Nelly Mugo, Ting Hong, Connie Celum, Mark A Marzinke, Kenneth Ngure, Stephen Asiimwe, Elly Katabira, Elizabeth Bukusi, Josephine Odoyo, Edna Tindimwebwa, Nulu Bulya, Jared M Baeten
BACKGROUND: Global guidelines recommend pre-exposure prophylaxis (PrEP) use by women at risk for HIV, including during pregnancy, a period with heightened HIV risk. However, data to support safety of PrEP use during pregnancy are limited, particularly from women using PrEP throughout pregnancy. METHODS: In an open-label delivery study of PrEP integrated with ART for high risk HIV serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project), women who became pregnant while using PrEP were offered the option to continue PrEP throughout pregnancy...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29760706/complement-opsonized-hiv-1-alters-cross-talk-between-dendritic-cells-and-natural-killer-nk-cells-to-inhibit-nk-killing-and-to-upregulate-pd-1-cxcr3-and-ccr4-on-t-cells
#12
Rada Ellegård, Mohammad Khalid, Cecilia Svanberg, Hanna Holgersson, Ylva Thorén, Mirja Karolina Wittgren, Jorma Hinkula, Sofia Nyström, Esaki M Shankar, Marie Larsson
Dendritic cells (DCs), natural killer (NK) cells, and T cells play critical roles during primary HIV-1 exposure at the mucosa, where the viral particles become coated with complement fragments and mucosa-associated antibodies. The microenvironment together with subsequent interactions between these cells and HIV at the mucosal site of infection will determine the quality of immune response that ensues adaptive activation. Here, we investigated how complement and immunoglobulin opsonization influences the responses triggered in DCs and NK cells, how this affects their cross talk, and what T cell phenotypes are induced to expand following the interaction...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760177/epigenetic-promoter-dna-methylation-of-mir-124-promotes-hiv-1-tat-mediated-microglial-activation-via-mecp2-stat3-axis
#13
Palsamy Periyasamy, Annadurai Thangaraj, Ming-Lei Guo, Guoku Hu, Shannon Callen, Shilpa Buch
The present study demonstrates HIV-1 Tat-mediated epigenetic downregulation of microglial miR-124 and its association with microglial activation. Exposure of mouse primary microglia isolated from newborn pups of either sex to HIV-1 Tat resulted in decreased expression of primary miR-124-1, primary miR-124-2 as well as the mature miR-124. In parallel, HIV-1 Tat exposure to mouse primary microglial cells resulted in increased expression of DNA methylation enzymes, such as DNMT1, DNMT3A, and DNMT3B that were also accompanied by increased global DNA methylation...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29754266/reaching-the-first-90-in-uganda-predictors-of-success-in-contacting-and-testing-the-named-sexual-partners-of-hiv-index-clients-in-kiboga-district
#14
Katherine Buhikire, Joachim Voss, Joanita Kigozi, Patience Nyakato, Nickson Ankunda, Brenda Kalebbo, Michael Musiitwa, Alex Muganzi, Nelson K Sewankambo, Damalie Nakanjako
Assisted partner notification programs represent one strategy for targeted HIV testing and treatment of exposed individuals in high-risk populations. This study of a pilot Partner Services program in rural Uganda describes predictors of successful contact tracings and testing of partners of HIV+ individuals and possible barriers to contact. Partner contact tracing data was extracted from registers at seven Ministry of Health facilities between May and October 2016, to inform program implementation and scale up...
May 12, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29752892/high-vertical-hiv-transmission-rate-in-the-midwest-region-of-brazil
#15
Vanessa Terezinha Gubert de Matos, Fabiani de Morais Batista, Naiara Valera Versage, Clarice Souza Pinto, Vanessa Marcon de Oliveira, Érica Freire de Vasconcelos Pereira, Roberta Barbeta Dos Rios de Matos, Márcia Maria Ferrairo Janini Dal Fabbro, Ana Lúcia Lyrio de Oliveira
OBJECTIVES: To estimate vertical HIV transmission rate in a capital city of the Midwest region of Brazil and describe the factors related to transmission. METHODS: A descriptive epidemiological study based on the analysis of secondary data from the Notifiable Diseases Information System (SINAN). The analysis considered all HIV-infected pregnant women with delivery in Campo Grande-MS in the years 2007-2013 and their HIV-exposed infants. RESULTS: A total of 218 births of 176 HIV-infected pregnant women were identified during the study period, of which 187 infants were exposed and uninfected, 19 seroconverted, and 12 were still inconclusive in July 2015...
May 9, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29752681/critical-role-of-beclin1-in-hiv-tat-and-morphine-induced-inflammation-and-calcium-release-in-glial-cells-from-autophagy-deficient-mouse
#16
Jessica Lapierre, Myosotys Rodriguez, Chet Raj Ojha, Nazira El-Hage
We previously showed that autophagy is an important component in human immunodeficiency virus (HIV) replication and in the combined morphine-induced neuroinflammation in human astrocytes and microglia. Here we further studied the consequences of autophagy using glial cells of mice partially lacking the essential autophagy gene Atg6 (Beclin1) exposed to HIV Tat and morphine. Tat is known to cause an inflammatory response, increase calcium release, and possibly interact with autophagy pathway proteins. Following Tat exposure, autophagy-deficient (Becn1+/- ) glial cells had significantly and consistently reduced levels in the pro-inflammatory cytokine IL-6 and the chemokines RANTES and MCP-1 when compared to Tat-treated cells from control (C57BL/6J) mice, suggesting an association between the inflammatory effects of Tat and Beclin1...
May 11, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29750766/infectious-morbidity-mortality-and-nutrition-in-hiv-exposed-uninfected-formula-fed-infants-results-from-the-hptn-040-pactg-1043-trial
#17
Nava Yeganeh, D Heather Watts, Jiahong Xu, Tara Kerin, Esau C Joao, Jose Henrique Pilotto, Gerhard Theron, Glenda Gray, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Valdilea Veloso, Margaret Camarca, Lynne Mofenson, Jack Moye, Karin Nielsen-Saines
BACKGROUND: HIV exposed uninfected (HEU) infants are a growing population with potentially poor health outcomes. We evaluated morbidity and mortality in HEU formula-fed infants enrolled in the NICHD HPTN 040/PACTG 1043 trial. METHODS: Infectious morbidity, mortality, and undernutrition were evaluated within a cohort of 1,000 HEU infants enrolled between 4/2004 and 4/2010 in Brazil (N=766) and South Africa (N=234) as part of the NICHD/HPTN 040 trial of three different antiretroviral regimens to decrease intrapartum HIV vertical transmission...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29747664/adverse-effects-in-children-exposed-to-maternal-hiv-and-antiretroviral-therapy-during-pregnancy-in-brazil-a-cohort-study
#18
Adriane M Delicio, Giuliane J Lajos, Eliana Amaral, Fernanda Cavichiolli, Marina Polydoro, Helaine Milanez
BACKGROUND: Antiretroviral therapy (ART) in pregnancy was associated with a drastic reduction in HIV mother-to-child transmission (MTCT), although it was associated with neonatal adverse effects. The aim of this study was to evaluate the neonatal effects to maternal ART. METHODS: This study was a cohort of newborns from HIV pregnant women followed at the CAISM/UNICAMP Obstetric Clinic from 2000 to 2015. The following adverse effects were evaluated: anemia, thrombocytopenia, liver function tests abnormalities, preterm birth, low birth weight and congenital malformation...
May 10, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29747581/mother-to-child-transmission-of-hiv-infection-and-its-associated-factors-in-ethiopia-a-systematic-review-and-meta-analysis
#19
Getachew Mullu Kassa
BACKGROUND: Mother-to-child transmission (MTCT) is the main mode of HIV transmission in children under 15 years old. This problem is significant in the Sub-Saharan African countries, where more than 80% of children living with HIV are found. Previous studies in Ethiopia present inconsistent and inconclusive findings on the prevalence and associated factors of MTCT of HIV. Therefore, this study was conducted to determine the pooled prevalence of MTCT of HIV and its associated factors in Ethiopia...
May 10, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29746376/neruodevelopmental-outcomes-in-pre-school-children-living-with-hiv-1-subtypes-a-and-d-in-uganda
#20
Horacio Ruiseñor-Escudero, Alla Sikorskii, Itziar Familiar-Lopez, Deborah Persaud, Carrie Ziemniak, Noeline Nakasujja, Robert Opoka, Michael Boivin
BACKGROUND: HIV is a neuropathogenic virus that may result in detrimental neurodevelopmental (ND) outcomes early in life. This is the first study to evaluate the effect of HIV-1 subtype on neurodevelopment of Ugandan pre-school children. METHODS: Neurodevelopment of 87 HIV-1 infected and 221 HIV exposed uninfected (HEU) Ugandan children aged 1.8 to 4.9 years was assessed using four scales of the Mullen Scales of Early Learning (MSEL), two scales of the Color Object Association Test (COAT), and one score of the Early Childhood Vigilance Test (ECVT)...
May 9, 2018: Pediatric Infectious Disease Journal
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