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https://www.readbyqxmd.com/read/29330881/cocaine-and-hiv-1-tat-disrupt-cholesterol-homeostasis-in-astrocytes-implications-for-hiv-associated-neurocognitive-disorders-in-cocaine-user-patients
#1
Bianca Cotto, Kalimuthusamy Natarajaseenivasan, Kimberly Ferrero, Leroy Wesley, Matthew Sayre, Dianne Langford
Cholesterol synthesis and clearance by astrocytes are tightly regulated to maintain constant levels within the brain. In this context, liver X receptors (LXRs) are the master regulators of cholesterol homeostasis in the central nervous system (CNS). Increasing levels of cholesterol in astrocytes trigger LXR activation leading to the transcription of target genes involved in cholesterol trafficking and efflux, including apolipoprotein E, cytochrome P450 enzymes, sterol regulatory binding protein, and several ATP-binding cassette transporter proteins...
January 13, 2018: Glia
https://www.readbyqxmd.com/read/29330339/hiv-positive-kidney-donor-selection-for-hiv-positive-transplant-recipients
#2
Elmi Muller, Zunaid Barday
The risks associated with transplanting HIV-positive kidneys into HIV-positive recipients have not been well studied. Since 2008, 43 kidneys from 25 HIV-positive deceased donors have been transplanted into patients who are HIV positive in Cape Town, South Africa. Among the donors, 19 (76%) died secondary to trauma. The average age for donors was 34 (interquartile range, 19-52) years old. In some donors, only one kidney was used because of a limited number of suitable recipients on the waiting list. Only two donors had been previously exposed to antiretroviral triple therapy...
January 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29323435/soluble-cd14-levels-in-plasma-and-breastmilk-of-malawian-hiv-women-lack-of-association-with-morbidity-and-mortality-in-their-exposed-infants
#3
Silvia Baroncelli, Clementina M Galluzzo, Giuseppe Liotta, Mauro Andreotti, Fausto Ciccacci, Sandro Mancinelli, Victor T Tolno, Jane Gondwe, Roberta Amici, Maria C Marazzi, Stefano Vella, Marina Giuliano, Leonardo Palombi, Lucia Palmisano
PROBLEM: Data on soluble CD14 (sCD14) during pregnancy and lactation are scarce. We assessed the levels of sCD14 in plasma and breastmilk of Malawian HIV-positive women and evaluated the possible association with morbidity and mortality in the HIV-exposed children. METHOD OF STUDY: One hundred and forty-nine mother/child pairs were studied. Women received antiretroviral therapy from 26 weeks of gestation to at least 6 months of exclusive breastfeeding. sCD14 concentrations were determined using an enzyme-linked immunosorbent assay...
January 11, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29320552/first-report-of-occult-hepatitis-b-infection-among-art-na%C3%A3-ve-hiv-seropositive-individuals-in-maputo-mozambique
#4
Awa Abdul Carimo, Eduardo Samo Gudo, Cremildo Maueia, Nédio Mabunda, Lúcia Chambal, Adolfo Vubil, Ana Flora, Francisco Antunes, Nilesh Bhatt
BACKGROUND: The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown. OBJECTIVES: This study was conducted with the aim to investigate the prevalence of OBI and frequency of isolated hepatitis B core antibody (anti-HBc alone) among antiretroviral (ART) naïve HIV-positive patients in Mozambique...
2018: PloS One
https://www.readbyqxmd.com/read/29319636/optimal-antiretroviral-prophylaxis-in-infants-at-high-risk-of-acquiring-hiv-a-systematic-review
#5
Sara Beste, Shaffiq Essajee, George Siberry, Alisse Hannaford, Jasmeen Dara, Nandita Sugandhi, Martina Penazzato
INTRODUCTION: The risk of perinatal HIV infection can be dramatically reduced through maternal antiretroviral (ARV) therapy and infant ARV postnatal prophylaxis. The 2013 World Health Organization guidelines recommended 4-6 weeks of nevirapine or zidovudine as postnatal prophylaxis, with possible extension to 12 weeks for high-risk breastfed infants. A systematic review was undertaken to determine if there is evidence for the World Health Organization to recommend enhanced or extended prophylaxis for high-risk infants...
February 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29317437/infant-feeding-practices-among-hiv-exposed-infants-less-than-6-months-of-age-in-bomet-county-kenya-an-in-depth-qualitative-study-of-feeding-choices
#6
Purity Chepkorir Lang'at, Irene Ogada, Audrey Steenbeek, Noni E MacDonald, Sophie Ochola, Wesley Bor, Godfrey Odinga
BACKGROUND: In children, HIV can be acquired from the mother during pregnancy, delivery and through breast milk. The WHO recommends exclusive breast feeding or exclusive replacement feeding for the first 6 months after birth for HIV-exposed infants. Barriers such as HIV-related stigma, inadequate resources, lack of access to safe water and negative cultural beliefs have been shown to influence infant feeding among HIV-exposed infants in some settings. In Kenya, there is limited literature on the barriers...
January 9, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29304470/protein-s-and-gas6-induce-efferocytosis-of-hiv-1-infected-cells
#7
Bernadette Anne Chua, Jamie Ann Ngo, Kathy Situ, Christina M Ramirez, Haruko Nakano, Kouki Morizono
Efferocytosis, the phagocytic clearance of apoptotic cells, can provide host protection against certain types of viruses by mediating phagocytic clearance of infected cells undergoing apoptosis. It is known that HIV-1 induces apoptosis and HIV-1-infected cells are efferocytosed by macrophages, although its molecular mechanisms are unknown. To elucidate the roles that efferocytosis of HIV-1-infected cells play in clearance of infected cells, we sought to identify molecules that mediate these processes. We found that protein S, present in human serum, and its homologue, Gas6, can mediate phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase Mer, expressed on macrophages, to phosphatidylserine exposed on infected cells...
January 2, 2018: Virology
https://www.readbyqxmd.com/read/29302327/uptake-and-predictors-of-early-postnatal-follow-up-care-amongst-mother-baby-pairs-in-south-africa-results-from-three-population-based-surveys-2010-2013
#8
Anna Larsen, Mireille Cheyip, Getahun Aynalem, Thu-Ha Dinh, Debra Jackson, Nobubelo Ngandu, Witness Chirinda, Mary Mogashoa, Gupreet Kindra, Carl Lombard, Ameena Goga
Background: Achieving World Health Organization (WHO) recommendations for postnatal care (PNC) within the first few weeks of life is vital to eliminating early mother-to-child transmission of HIV (MTCT) and improving infant health. Almost half of the annual global deaths among children under five occur during the first six weeks of life. This study aims to identify uptake of three PNC visits within the first six weeks of life as recommended by WHO among South African mother-infant pairs, and factors associated with uptake...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29302320/knowledge-about-mother-to-child-transmission-of-hiv-its-prevention-and-associated-factors-among-ethiopian-women
#9
Tegene Regassa Luba, Zhanchun Feng, Simon Afewerki Gebremedhin, Asfaw N Erena, Abdulsalam Ma Nasser, Ghose Bishwajit, Shangfeng Tang
Background: Poor awareness and knowledge of mother-to-child transmission (MTCT),that accounts for over 90% of new HIV infections among children, might contribute to the HIV epidemics. In Ethiopia, 898 400 children are orphaned due to HIV and AIDS and 200 300 were living with HIV in 2013. The main objective of this study was to examine the knowledge of MTCT of HIV, its prevention (PMTCT) and associated factors among Ethiopian women. Methods: We conducted a cross-sectional analysis among 16 515 women from the Ethiopian Demographic Health Survey (EDHS) 2011...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29301007/low-birth-weight-in-human-immunodeficiency-virus-exposed-uninfected-infants-in-bronx-new-york
#10
Jasmeen S Dara, David B Hanna, Kathryn Anastos, Rodney Wright, Betsy C Herold
Background: Prevention of mother-to-child transmission of human immunodeficiency virus (HIV) with antiretroviral therapy (ART) has been highly successful. However, HIV-exposed uninfected (HIV-EU) infants might be at increased risk for low birth weight and/or preterm birth. We compared the birth weights and gestational ages of HIV-EU infants to those of HIV-unexposed control infants in Bronx, New York, an epicenter of the HIV epidemic in the United States. Methods: This study was performed with a retrospective cohort of HIV-EU infants born at Montefiore Medical Center between 2008 and 2012 and HIV-unexposed control infants...
December 30, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29294866/the-association-between-intimate-partner-violence-and-signs-of-depression-during-pregnancy-in-kilimanjaro-region-northern-tanzania
#11
Rachel Manongi, Jane Rogathi, Geofrey Sigalla, Declare Mushi, Vibeke Rasch, Tine Gammeltoft, Dan W Meyrowitsch
Intimate partner violence (IPV) against pregnant women is common with severe health consequences to women and their babies. The aim of the present study is to measure the association between IPV and signs of depression among pregnant women attending antenatal care in a semi-urban setting in northern Tanzania. A cross-sectional study was conducted from March 1, 2014, to May 30, 2015, among pregnant women attending routine antenatal care in Moshi Municipality, Tanzania. During their third trimester, self-reported exposure to IPV was assessed using a validated structured questionnaire adopted from the World Health Organization's (WHO) Multi-Country Study on Women's Health and Domestic Violence...
August 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294576/-study-on-the-risk-of-mortality-and-associated-factors-among-hiv-exposed-children-in-henan-province-2002-2014
#12
Q Wang, N Ma, H Si, Y M Ma, N Li, Y G Nie, D Y Sun, Z Wang
Objective: To investigate the status of survival and related risk factors among HIV-exposed children in Henan province from 2002 to 2014. Methods: A follow-up program was set up when infants as 1, 3, 6, 9, 12, 18 month olds. Data regarding the HIV-exposed children and their mothers were collected, including service of PMTCT, antiviral therapy, incidence of infectious disease and survival status of infants. Univariate and multivariate logistic regression models were used to explore the risk factors. Results: A total number of 1 705 HIV-infected infants were reported from 2002 to 2014...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29290955/effect-of-antiretroviral-therapy-use-and-adherence-on-the-risk-of-hyperlipidemia-among-hiv-infected-patients-in-the-highly-active-antiretroviral-therapy-era
#13
Fuu-Jen Tsai, Chi-Fung Cheng, Chih-Ho Lai, Yang-Chang Wu, Mao-Wang Ho, Jen-Hsien Wang, Ni Tien, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Jung-Chun Lin, Chih-Chien Lin, Jin-Hua Chen, Wen-Miin Liang, Ying-Ju Lin
HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281969/functional-expression-of-ccl8-and-its-interaction-with-chemokine-receptor-ccr3
#14
Baosheng Ge, Jiqiang Li, Zhijin Wei, Tingting Sun, Yanzhuo Song, Naseer Ullah Khan
BACKGROUND: Chemokines and their cognate receptors play important role in the control of leukocyte chemotaxis, HIV entry and other inflammatory diseases. Developing an effcient method to investigate the functional expression of chemokines and its interactions with specific receptors will be helpful to asses the structural and functional characteristics as well as the design of new approach to therapeutic intervention. RESULTS: By making systematic optimization study of expression conditions, soluble and functional production of chemokine C-C motif ligand 8 (CCL8) in Escherichia coli (E...
December 28, 2017: BMC Immunology
https://www.readbyqxmd.com/read/29280758/changes-in-insulin-sensitivity-over-time-and-associated-factors-in-hiv-infected-adolescents
#15
Mitchell E Geffner, Kunjal Patel, Denise L Jacobson, Julia Wu, Tracie L Miller, Rohan Hazra, Mariana Gerschenson, Tanvi Sharma, Margarita Silio, Jennifer Jao, Jody K Takemoto, Russell B Van Dyke, Linda A Dimeglio
OBJECTIVE: To compare prevalence of IR between perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected adolescents (PHEU), determine incidence of and contributory factors to new and resolved cases of IR in PHIV+, and evaluate glucose metabolism. DESIGN: Cross-sectional design for comparison of prevalence among PHIV+ and PHEU. Longitudinal design for incidence and resolution of IR among PHIV+ at risk for these outcomes. METHODS: The source population was adolescents from pediatric HIV clinics in the US and Puerto Rico participating in PHACS AMP, an ongoing prospective cohort study designed to evaluate impact of HIV infection and its treatment on multiple domains in preadolescents and adolescents...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29278615/risk-for-speech-and-language-impairments-in-pre-school-aged-hiv-exposed-uninfected-children-with-in-utero-combination-antiretroviral-exposure
#16
Mabel L Rice, Jonathan S Russell, Toni Frederick, Murli Purswani, Paige L Williams, George K Siberry, Sean M Redmond, Howard J Hoffman, Tzy-Jyun Yao
BACKGROUND: Perinatally HIV-exposed but uninfected (HEU) children have elevated risk of late language emergence at age 1 year, with possible links to in utero antiretroviral (ARV) exposure. We investigated possible risks for speech impairments (SI) and language impairments (LI) in preschool monolingual HEU children in the United States. METHODS: Speech and language assessments were conducted as part of the PHACS Surveillance Monitoring of ART Toxicities (SMARTT) study at ages 3 (N= 208) and 5 (N = 429) years...
December 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29278542/potential-kidney-toxicity-from-the-antiviral-drug-tenofovir-new-indications-new-formulations-and-a-new-prodrug
#17
Lili Chan, Benjamin Asriel, Ellen F Eaton, Christina M Wyatt
PURPOSE OF REVIEW: The antiviral agent tenofovir is highly effective for the treatment of HIV and hepatitis B virus infections, and the older prodrug tenofovir disoproxil fumarate (TDF) is also a component of daily preexposure prophylaxis (PrEP) to reduce the risk of HIV infection in high-risk populations. Although TDF is well tolerated, the potential for kidney and bone toxicity has important implications for public health given the large number of individuals exposed to TDF worldwide...
December 22, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29261707/field-evaluation-of-hiv-point-of-care-testing-for-early-infant-diagnosis-in-cape-town-south-africa
#18
Lorna Dunning, Max Kroon, Nei-Yuan Hsiao, Landon Myer
BACKGROUND: Early infant HIV diagnosis (EID) coverage and uptake remains challenging. Point-of-care (POC) testing may improve access and turn-around-times, but, while several POC technologies are in development there are few data on their implementation in the field. METHODS: We conducted an implementation study of the Alere q Detect POC system for EID at two public sector health facilities in Cape Town. HIV-exposed neonates undergoing routine EID testing at a large maternity hospital and a primary care clinic received both laboratory-based HIV PCR testing per local protocols and a POC test...
2017: PloS One
https://www.readbyqxmd.com/read/29258818/remodeling-of-hiv-1-nef-structure-by-src-family-kinase-binding
#19
Jamie A Moroco, John Jeff Alvarado, Ryan P Staudt, Haibin Shic, Thomas E Wales, Thomas E Smithgall, John R Engen
The HIV-1 accessory protein Nef controls multiple aspects of the viral life cycle and host immune response, making it an attractive therapeutic target. Previous X-ray crystal structures of Nef in complex with key host cell binding partners have shed light on protein-protein interactions critical to Nef function. Crystal structures of Nef in complex with either the SH3 or tandem SH3-SH2 domains of Src-family kinases reveal distinct dimer conformations of Nef. However, the existence of these Nef dimer complexes in solution has not been established...
December 16, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29258786/genetic-and-immune-determinants-of-immune-activation-in-hiv-exposed-seronegative-individuals-and-their-role-in-protection-against-hiv-infection
#20
Claudio Fenizia, Jean-François Rossignol, Mario Clerici, Mara Biasin
Soon thereafter infection is established, hosts strive for an efficient eradication of microorganisms, with as limited tissue damage as possible, and durable immunological protection against re-infection. On the other hand, pathogens have developed countermeasures to escape host surveillance and to warrant diffusion to other hosts. In this molecular arms race the final results relies on multiple variables, including the genetic and immunologic e correlates of protection available for the host. In the field of HIV-infection, natural protection has been repeatedly associated to the presence of an immune activation state, at least in some cohorts of HESN (HIV-exposed seronegative)...
December 16, 2017: Infection, Genetics and Evolution
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