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Jing Chen, Xibao Shi, Xiaozhuan Zhang, Aiping Wang, Li Wang, Yanyan Yang, Ruiguang Deng, Gai-Ping Zhang
: microRNAs (miRNAs) played an important role in the regulation of immune response. Previous studies have indicated that dysregulating the miRNAs may lead to the immunosuppression of porcine reproductive and respiratory syndrome virus (PRRSV). However, it's not clear about how PRRSV regulated the expression of host miRNA which may make the immune escape or promote the replication of the virus. The present work suggested that PRRSV up-regulated the expression of miR-373 through elevating the expression of specificity protein 1 (Sp1) in MARC-145 cells...
November 23, 2016: Journal of Virology
James Fraser, Alexandra Essebier, Richard M Gronostajski, Mikael Boden, Brandon J Wainwright, Tracey J Harvey, Michael Piper
Transcription factors from the nuclear factor one (NFI) family have been shown to play a central role in regulating neural progenitor cell differentiation within the embryonic and post-natal brain. NFIA and NFIB, for instance, promote the differentiation and functional maturation of granule neurons within the cerebellum. Mice lacking Nfix exhibit delays in the development of neuronal and glial lineages within the cerebellum, but the cell-type-specific expression of this transcription factor remains undefined...
November 23, 2016: Brain Structure & Function
Juan Carlos Bazo-Alvarez, Oscar Alfredo Bazo-Alvarez, Jeins Aguila, Frank Peralta, Wilfredo Mormontoy, Ian M Bennett
Objetives.: Our aim was to evaluate the psychometric properties of the FACES-III among Peruvian high school students. Materials and Methods.: This is a psychometric cross-sectional study. A probabilistic sampling was applied, defined by three stages: stratum one (school), stratum two (grade) and cluster (section). The participants were 910 adolescent students of both sexes, between 11 and 18 years of age. The instrument was also the object of study: the Olson's FACES-III...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
Pablo Espinosa, Miguel Clemente, Octavio Uña
This study examines the role that motivational values play in the experience of discrimination in young immigrants in Spain and how this role is mediated by parental values. Participants in the study were 193 dyads of pre-adolescent to young adult first and second generation immigrants and one of their parents. All participants were either of Moroccan or Romanian ascent, the two largest immigrant groups in Spain. The proposed SEM model had an adequate fit, χ2(2, N = 193) = 2.272, p = .321, RMSEA = .027, CFI = ...
November 8, 2016: Spanish Journal of Psychology
Young Sun Kim, T Greg Rhee, Hee Yun Lee, Byung Hyun Park, Monica L Sharratt
BACKGROUND: Existing literature suggests that mental health literacy is positively associated with mental health services utilization. Despite an aging population that faces significant mental health concerns in Korea, the role of mental health literacy on mental health services utilization is not known among older adults in Korea. This study aimed to (1) identify whether mental health literacy mediates the association between population characteristics and mental health services utilization and (2) identify an optimal path model for mental health services utilization among Korean older adults...
October 20, 2016: International Psychogeriatrics
Ilan Gobius, Laura Morcom, Rodrigo Suárez, Jens Bunt, Polina Bukshpun, William Reardon, William B Dobyns, John L R Rubenstein, A James Barkovich, Elliott H Sherr, Linda J Richards
The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4,000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of callosal axons is dependent upon the prior remodeling and degradation of the intervening interhemispheric fissure. This remodeling event is initiated by astroglia on either side of the interhemispheric fissure, which intercalate with one another and degrade the intervening leptomeninges...
October 11, 2016: Cell Reports
Fariba Nikan, Mohammad Asghari Jafarabadi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Ali Montazeri, Sonia Asadi
BACKGROUND: There are some specific measures for the evaluation of postpartum quality of life, and each have some limitations. OBJECTIVES: This study investigated the validity and reliability of the Persian version of a postpartum women's quality of life (PQOL) questionnaire at the eighth week of postpartum. PATIENTS AND METHODS: This was a methodological research, and subjects were 500 women, ages 18 - 42, eight weeks postpartum, randomly selected from half of the public centers in Tabriz, Iran, who completed questionnaires in a self-administered manner...
July 2016: Iranian Red Crescent Medical Journal
Mayis Al-Dughmi, Catherine F Siengsukon
OBJECTIVES: The Neurological Fatigue Index (NFI-MS) is the only known perceived fatigue scale to include questions that consider the contribution of sleep quality to symptoms of fatigue in people with multiple sclerosis (MS). However, the relationship between the NFI-MS and sleep quality measures is unknown. This study aimed to explore the relationship between the NFI-MS and self-reported and objective sleep quality. Understanding the relationship between perceived fatigue and sleep quality measures could encourage a wider use of the NFI-MS in research and clinical settings...
September 16, 2016: Neurological Research
Dnika J Travis, Erica Leeanne Lizano, Michàlle E Mor Barak
The well-documented day-to-day and long-term experiences of job stress and burnout among employees in child welfare organisations increasingly raise concerns among leaders, policy makers and scholars. Testing a theory-driven longitudinal model, this study seeks to advance understanding of the differential impact of job stressors (work-family conflict, role conflict and role ambiguity) and burnout (emotional exhaustion and depersonalisation) on employee disengagement (work withdrawal and exit-seeking behaviours)...
June 2016: British Journal of Social Work
Tarun Narang, Arshdeep, Sunil Dogra
Nerve function impairment (NFI) in leprosy may occur and progress despite multidrug therapy alone or in combination with corticosteroids. We observed improvement in neuritis when minocycline was administered in patients with type 2 lepra reaction. This prompted us to investigate the role of minocycline in recent onset NFI, especially in corticosteroid unresponsive leprosy patients. Leprosy patients with recent onset clinical NFI (<6 months), as determined by Monofilament Test (MFT) and Voluntary Muscle Test (VMT), were recruited...
August 23, 2016: Dermatologic Therapy
Yan Teng, Junming Miao, Xiaofei Shen, Xiaolong Yang, Xinyuan Wang, Laibin Ren, Xiaoying Wang, Junli Chen, Jingyu Li, Shanze Chen, Yi Wang, Ning Huang
Micro-RNAs (miRNAs) critically regulate several host defense mechanisms, but their roles in the bacteria-epithelium interplay remain unclear. Our results displayed that the expression of miR-155 and miR-23a were down-regulated in K. pneumoniae-infected pulmonary epithelial cells. The elevated bacterial adhesion on A549 cells followed the enhancement of the cellular levels of these two miRNAs. Meanwhile, a mechanistic study demonstrated that miR-155 promoted integrin α5β1 function and resulted in the increased actin polymerization...
2016: Scientific Reports
Jun-cheng Chen, Yu-ruo Yan, Li Ai, Xue-hua Guo, Jian-xiu He, Ping Yuan
OBJECTIVE: To develop a questionnaire measuring sexual mental health of Tibetan university students. METHODS: A draft questionnaire was developed with reference to the Sexual Civilization Survey for University Students of New Century and other published literature, and in consultation with experts. The questionnaire was tested in 230 students. Exploratory factor analyses with principal component and varimax orthogonal rotation were performed. Common factors with a > 1 eigenvalues and ≥ 3 loaded items (factor loading ≥ 0...
May 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Wanderson Roberto Silva, David Costa, Filipa Pimenta, João Maroco, Juliana Alvares Duarte Bonini Campos
The objectives of this study were to develop a unified Portuguese-language version, for use in Brazil and Portugal, of the Body Shape Questionnaire (BSQ) and to estimate its validity, reliability, and internal consistency in Brazilian and Portuguese female university students. Confirmatory factor analysis was performed using both original (34-item) and shortened (8-item) versions. The model's fit was assessed with χ²/df, CFI, NFI, and RMSEA. Concurrent and convergent validity were assessed. Reliability was estimated through internal consistency and composite reliability (α)...
July 21, 2016: Cadernos de Saúde Pública
Yingtao Li, Yingchun Zeng, Wei Zhu, Ying Cui, Jie Li
BACKGROUND: Antenatal maternal mental health problems have numerous consequences for the well-being of both mother and child. This study aimed to test and construct a pertinent model of antenatal depressive symptoms within the conceptual framework of a stress process model. METHODS: This study utilized a cross-sectional study design. INCLUSION CRITERIA: participants were adult women (18 years or older) having a healthy pregnancy, in their third trimester (the mean weeks gestation was 34...
2016: BMC Pregnancy and Childbirth
Gül Seçkin, Dale Yeatts, Susan Hughes, Cassie Hudson, Valarie Bell
BACKGROUND: The Internet, with its capacity to provide information that transcends time and space barriers, continues to transform how people find and apply information to their own lives. With the current explosion in electronic sources of health information, including thousands of websites and hundreds of mobile phone health apps, electronic health literacy is gaining an increasing prominence in health and medical research. An important dimension of electronic health literacy is the ability to appraise the quality of information that will facilitate everyday health care decisions...
2016: Journal of Medical Internet Research
Qais Alefan, Aseel Karasneh, Faris El-Dahiyat, Mohd Alshara, Dania Abu-Naser
BACKGROUND: Generic drugs are considered the best alternative for the originator brand drugs because they have the same quality, safety, and efficacy yet offered at considerbaly lower cost. Prior research has developed instrumentation to assess patients' perceptions of generic drugs; however, little has been done to translate these measures in other languages. OBJECTIVES: This study's aim was to translate and validate an Arabic version of the generic drug scale (GMS) in a Jordanian sample...
June 3, 2016: Research in Social & Administrative Pharmacy: RSAP
A G Actis, E Versino, B Brogliatti, T Rolle
PURPOSE: Aim of this retrospective, observational study is to describe features of a population sample, affected by primary open angle glaucoma (POAG) in order to evaluate damage progression on the basis of the emerged individual risk factors. METHODS: We included 190 caucasian patients (377 eyes), evaluating relationship between individual risk factors (explicative variables) and MD (Mean Deviation) of standard automated perimetry. We also considered the dependent variable NFI (Neural Fiber Index) of GDx scanning laser polarimetry...
2016: Open Ophthalmology Journal
Marta Sabater-Galindo, Daniel Sabater-Hernández, Salvador Ruiz de Maya, Miguel Angel Gastelurrutia, Fernando Martínez-Martínez, Shalom I Benrimoj
Professional pharmaceutical services may impact on patient's health behaviour as well as influence on patients' perceptions of the pharmacist image. The Health Belief Model predicts health-related behaviours using patients' beliefs. However, health beliefs (HBs) could transcend beyond predicting health behaviour and may have an impact on the patients' perceptions of the pharmacist image. This study objective was to develop and test a model that relates patients' HBs to patient's perception of the image of the pharmacist, and to assess if the provision of pharmacy services (Intervention group-IG) influences this perception compared to usual care (Control group)...
June 13, 2016: Psychology, Health & Medicine
Ming-Ming Lai, Shi-Ying Lein, Siok-Hwa Lau, Ming-Ling Lai
This paper empirically tested eight key features of WHO guidelines to age-friendly community by surveying 211 informal caregivers and 402 self-care adults (aged 45 to 85 and above) in Malaysia. We examined the associations of these eight features with active aging and social connectedness through exploratory and confirmatory factor analyses. A structural model with satisfactory goodness-of-fit indices (CMIN/df = 1.11, RMSEA = 0.02, NFI = 0.97, TLI = 1.00, CFI = 1.00, and GFI = 0.96) indicates that transportation and housing, community support and health services, and outdoor spaces and buildings are statistically significant in creating an age-friendly environment...
2016: Journal of Aging Research
Hongyan Wang, Di Wu, Xiaofeng Wang, Guang Chen, Yuanya Zhang, Weiming Yan, Xiaoping Luo, Meifang Han, Qin Ning
The protein inhibitor of activated STAT1 (PIAS1) plays important roles in regulating virusinduced chronic hepatitis, but the interaction between hepatitis B virus (HBV) and hPIAS1 is not clear. Our aim was to verify if HBV encoding proteins enhance the transcription of hPIAS1 and which cis-elements and transcription factors were involved in the mechanism. In order to do, so a series of molecular biological methods, along with functional and histological studies, were performed. We found that the HBV surface protein (HBs) enhanced hPIAS1 transcription through the activities of TAL1, E47, myogenin (MYOG), and NFI, dependent on the activation of p38MAPK and ERK signaling pathways in vitro, which might contribute to the ineffectiveness of treatment in CHB patients...
June 8, 2016: Biological Chemistry
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