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https://www.readbyqxmd.com/read/29172874/nfia-deletion-in-myeloid-cells-blocks-expansion-of-myeloid-derived-suppressor-cells-during-sepsis
#1
Jun Dai, Ajinkya Kumbhare, Danielle A Williams, Dima Youssef, Zhi Q Yao, Charles E McCall, Mohamed El Gazzar
Sepsis-induced immunosuppression increases the risk of chronic infection and reduces survival. Myeloid-derived suppressor cells (MDSCs) expand in the bone marrow and spleen during murine polymicrobial sepsis, contributing to immunosuppression. A better understanding of molecular controls of MDSC production is needed to identify treatment targets. We previously reported that miR-21 and miR-181b couple with transcription factor NFI-A to induce MDSCs during murine sepsis. Here, we expand upon these observations by showing that conditional deletion of the Nfia gene in the myeloid lineage precludes MDSC development...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/29172826/testing-nursing-sensitive-outcomes-in-out-patient-drug-addicts-with-nursing-role-effectiveness-model
#2
Paulo Rosário Carvalho Seabra, José Joaqui Penedos Amendoeira, Luis Octávio Sá
Our aim was to identify factors that contribute to a better outcome in drug users and to understand the effectiveness of nursing interventions, by applying "Nursing Role Effectiveness Model" (NREM). It's a correlational, cross-sectional study with 180 drug users in a methadone program, randomly selected from three community services. We identified that treatment time, lower co-morbidities, less poly-drug use, family support and being employed contribute to a better quality of life, better mental health, less substance addiction consequences and more satisfaction with nursing care (p < 0...
November 27, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29151563/-structural-equation-modeling-of-self-management-of-liver-transplant-recipients
#3
Mi Kyeong Jeon, Yeon Hwan Park
PURPOSE: The purpose of this study was to construct and test a structural equation model of self-management of liver transplant recipients based on self-determination theory. METHODS: Participants were 275 outpatients who received liver transplantation. A structured self-report questionnaire was used to assess health care providers' autonomy support, transplant-related characteristics, illness consequence perception, autonomy, competence, family relatedness, depression and self-management...
October 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29151560/-structural-equation-modeling-on-health-related-quality-of-life-in-adults-with-epilepsy
#4
Jeong Ok Ko, Myung Ha Lee
PURPOSE: This study aimed to identify variables influencing the health-related quality of life (HRQoL) of adults with epilepsy in order to establish a structural model and design an intervention strategy to improve patients' HRQoL. METHODS: The selected subjects were 212 patients with epilepsy aged between 18 and 70 years who were currently receiving treatment from hospital, general hospital, and clinic. They were surveyed using a structured questionnaire. RESULTS: The goodness of fit measures of the final hypothetical model were as follows: χ²/df=2...
October 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29126170/changes-in-social-support-over-time-in-a-faith-based-physical-activity-intervention
#5
Chandra R Story, Douglas Knutson, Jameisha B Brown, Erica Spears-Laniox, Idethia Shevon Harvey, Ziya Gizlice, Melicia C Whitt-Glover
African-American women report higher levels of chronic conditions and church attendance relative to the overall US population. Therefore, efforts have increased over the past decade to design church-based health promotion programs. The present study compared changes in religiosity, religious social support and general social support across time within a church-based physical activity study. In a clustered randomized controlled trial, 31 churches and ∼15 African-American women per church were recruited to participate...
November 8, 2017: Health Education Research
https://www.readbyqxmd.com/read/29106906/transcriptional-regulation-of-nfix-by-nfib-drives-astrocytic-maturation-within-the-developing-spinal-cord
#6
Elise Matuzelski, Jens Bunt, Danyon Harkins, Jonathan W C Lim, Richard M Gronostajski, Linda J Richards, Lachlan Harris, Michael Piper
During mouse spinal cord development, ventricular zone progenitor cells transition from producing neurons to producing glia at approximately embryonic day 11.5, a process known as the gliogenic switch. The transcription factors Nuclear Factor I (NFI) A and B initiate this developmental transition, but the contribution of a third NFI member, NFIX, remains unknown. Here, we reveal that ventricular zone progenitor cells within the spinal cord express NFIX after the onset of NFIA and NFIB expression, and after the gliogenic switch has occurred...
October 26, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29077561/polish-adaptation-and-validation-of-the-physical-appearance-comparison-scale-pacs-an-analysis-among-young-people-in-late-adolescence-in-the-context-of-obesity
#7
Anna Dzielska, Joanna Mazur, Hanna Nałęcz, Anna Oblacińska, Małgorzata Strucińska
INTRODUCTION: The PACS scale is a tool which is widely used in foreign studies to evaluate the tendency towards appearance comparisons in social situations. People inclined to make such comparisons reveal a higher level of dissatisfaction with their body and a higher inclination towards problem eating. PURPOSE OF THE STUDY: The main purpose of the study was to adapt the PACS scale. A factor structure assessment and reliability analysis of the Polish version was carried out...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/29070963/relationship-between-fatigability-and-perceived-fatigue-measured-using-the-neurological-fatigue-index-in-people-with-multiple-sclerosis
#8
Mayis Aldughmi, Jared Bruce, Catherine F Siengsukon
BACKGROUND: Understanding the relationship between perceived fatigue and performance fatigability could lead to more effective interventions to manage multiple sclerosis (MS)-related fatigue. However, the relationship between self-perceived fatigue measured using the Neurological Fatigue Index (NFI-MS) and performance fatigability in people with MS is unknown. We sought to explore the relationship between the NFI-MS and performance fatigability in people with MS. METHODS: Fifty-two participants (mean ± SD age, 46...
September 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/29062368/psychometric-properties-of-the-persian-version-of-death-depression-scale-revised-in-iranian-patients-with-acute-myocardial-infarction
#9
Hamid Sharif Nia, Saeed Pahlevan Sharif, Rebecca H Lehto, Kelly A Allen, Amir Hossein Goudarzian, Ameneh Yaghoobzadeh, Mohammad Ali Soleimani
Objective: Limited research has examined the psychometric properties of death depression scales in Persian populations with cardiac disease despite the need for valid assessment tools for evaluating depressive symptoms in patients with life-limiting chronic conditions. The present study aimed at evaluating the reliability and validity of the Persian Version of Death Depression Scale - Revised (DDS-R) in Iranian patients who had recent acute myocardial infarction (AMI). Method: This psychometric study was conducted with a convenience sample of 407 patients with AMI diagnosis who completed the Persian version of the DDS-R...
July 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29033668/integrative-research-identifies-71-new-plant-species-records-in-the-state-of-rio-grande-do-norte-brazil-and-enhances-a-small-herbarium-collection-during-a-funding-shortage
#10
Leonardo M Versieux, Nállarett Dávila, Geadelande C Delgado, Valdeci F de Sousa, Edweslley Otaviano de Moura, Tarciso Filgueiras, Marccus V Alves, Eric Carvalho, Daniel Piotto, Rafaela C Forzza, Alice Calvente, Jomar G Jardim
A National Forest Inventory (NFI) encompassing the entire territory of Brazil is in progress. It is coordinated and promoted by the Brazilian Forest Service of the Ministry of Environment. In each state, the NFI collaborates with local herbaria by receiving collected plant material and performing species identification. Consultants are hired by the NFI and work at the local herbaria under the supervision of a curator. In exchange for curatorial assistance, the NFI provides equipment and consumables for the herbarium...
2017: PhytoKeys
https://www.readbyqxmd.com/read/29028793/clinico-pathological-features-of-erythema-nodosum-leprosum-a-case-control-study-at-alert-hospital-ethiopia
#11
Edessa Negera, Stephen L Walker, Selfu Girma, Shimelis N Doni, Degafe Tsegaye, Saba M Lambert, Munir H Idriss, Yohanis Tsegay, Hazel M Dockrell, Abraham Aseffa, Diana N Lockwood
BACKGROUND: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. ENL is treated mainly with corticosteroids and corticosteroids are often required for extended periods of time which may lead to serious adverse effects...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29021612/il-15-promotes-human-myogenesis-and-mitigates-the-detrimental-effects-of-tnf%C3%AE-on-myotube-development
#12
Mary F O'Leary, Graham R Wallace, Andrew J Bennett, Kostas Tsintzas, Simon W Jones
Studies in murine cell lines and in mouse models suggest that IL-15 promotes myogenesis and may protect against the inflammation-mediated skeletal muscle atrophy which occurs in sarcopenia and cachexia. The effects of IL-15 on human skeletal muscle growth and development remain largely uncharacterised. Myogenic cultures were isolated from the skeletal muscle of young and elderly subjects. Myoblasts were differentiated for 8 d, with or without the addition of recombinant cytokines (rIL-15, rTNFα) and an IL-15 receptor neutralising antibody...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28991595/psychometric-properties-of-the-korean-version-of-the-infertility-self-efficacy-scale
#13
Ju Hee Kim, Han Jong Park, Jung Ho Kim, Soojin Chung, Hyon Joo Hong
PURPOSE: The Infertility Self-Efficacy scale (ISE) is an instrument used to identify infertility-related self-efficacy. The purpose of this study was to assess the reliability and validity of the Korean version of the ISE developed by Cousineau et al. in 2006. METHODS: The translated instrument was pilot-tested and administered to 314 women and men with a diagnosis of infertility. For estimating reliability, test-retest and the internal consistency reliability coefficients were calculated...
September 2017: Asian Nursing Research
https://www.readbyqxmd.com/read/28981673/economic-risk-of-bee-pollination-in-maine-wild-blueberry-vaccinium-angustifolium
#14
Eric Asare, Aaron K Hoshide, Francis A Drummond, George K Criner, Xuan Chen
Recent pollinator declines highlight the importance of evaluating economic risk of agricultural systems heavily dependent on rented honey bees or native pollinators. Our study analyzed variability of native bees and honey bees, and the risks these pose to profitability of Maine's wild blueberry industry. We used cross-sectional data from organic, low-, medium-, and high-input wild blueberry producers in 1993, 1997-1998, 2005-2007, and from 2011 to 2015 (n = 162 fields). Data included native and honey bee densities (count/m2/min) and honey bee stocking densities (hives/ha)...
July 25, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28976976/effectiveness-of-32-versus-20-weeks-of-prednisolone-in-leprosy-patients-with-recent-nerve-function-impairment-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Inge Wagenaar, Erik Post, Wim Brandsma, Bob Bowers, Khorshed Alam, Vanaja Shetty, Vivek Pai, Sajid Husain, Cita Rosita Sigit Prakoeswa, Linda Astari, Deanna Hagge, Mahesh Shah, Kapil Neupane, Krishna Bahadur Tamang, Peter Nicholls, Jan Hendrik Richardus
BACKGROUND: While prednisolone is commonly used to treat recent nerve function impairment (NFI) in leprosy patients, the optimal treatment duration has not yet been established. In this "Treatment of Early Neuropathy in Leprosy" (TENLEP) trial, we evaluated whether a 32-week prednisolone course is more effective than a 20-week course in restoring and improving nerve function. METHODS: In this multi-centre, triple-blind, randomized controlled trial, leprosy patients who had recently developed clinical NFI (<6 months) were allocated to a prednisolone treatment regimen of either 20 weeks or 32 weeks...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28962832/the-convergent-roles-of-the-nuclear-factor-i-transcription-factors-in-development-and-cancer
#16
Kok-Siong Chen, Jonathan W C Lim, Linda J Richards, Jens Bunt
The nuclear factor I (NFI) transcription factors play important roles during normal development and have been associated with developmental abnormalities in humans. All four family members, NFIA, NFIB, NFIC and NFIX, have a homologous DNA binding domain and function by regulating cell proliferation and differentiation via the transcriptional control of their target genes. More recently, NFI genes have also been implicated in cancer based on genomic analyses and studies of animal models in a variety of tumours across multiple organ systems...
September 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28934717/expression-of-c-ebp%C3%AE-in-myeloid-progenitors-during-sepsis-promotes-immunosuppression
#17
Jun Dai, Ajinkya Kumbhare, Dima Youssef, Zhi Q Yao, Charles E McCall, Mohamed El Gazzar
Sepsis-induced myeloid-derived suppressor cells (MDSCs) contribute to immunosuppression associated with sepsis. We reported that the CCAAT enhancer-binding protein C/EBPβ activates microRNA (miR)-21 and miR-181b expressions, which induce transcription factor NFI-A to support the generation and expansion of MDSCs in the bone marrow and spleens of septic mice. Here, using a conditional knockout mouse model lacking C/EBPβ in the myeloid lineage, we find that without C/EBPβ, myeloid progenitor cells could not express miR-21 or miR-181b, and ectopic expression of C/EBPβ in the C/EBPβ-deficient myeloid progenitors activated the expression of the two miRNAs...
November 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28930691/dna-methylome-analysis-identifies-transcription-factor-based-epigenomic-signatures-of-multilineage-competence-in-neural-stem-progenitor-cells
#18
Tsukasa Sanosaka, Takuya Imamura, Nobuhiko Hamazaki, MuhChyi Chai, Katsuhide Igarashi, Maky Ideta-Otsuka, Fumihito Miura, Takashi Ito, Nobuyuki Fujii, Kazuho Ikeo, Kinichi Nakashima
Regulation of the epigenome during in vivo specification of brain stem cells is still poorly understood. Here, we report DNA methylome analyses of directly sampled cortical neural stem and progenitor cells (NS/PCs) at different development stages, as well as those of terminally differentiated cortical neurons, astrocytes, and oligodendrocytes. We found that sequential specification of cortical NS/PCs is regulated by two successive waves of demethylation at early and late development stages, which are responsible for the establishment of neuron- and glia-specific low-methylated regions (LMRs), respectively...
September 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/28917131/the-development-and-psychometric-testing-of-a-disaster-response-self-efficacy-scale-among-undergraduate-nursing-students
#19
Hong-Yan Li, Rui-Xue Bi, Qing-Ling Zhong
BACKGROUND: Disaster nurse education has received increasing importance in China. Knowing the abilities of disaster response in undergraduate nursing students is beneficial to promote teaching and learning. However, there are few valid and reliable tools that measure the abilities of disaster response in undergraduate nursing students. OBJECTIVES: To develop a self-report scale of self-efficacy in disaster response for Chinese undergraduate nursing students and test its psychometric properties...
December 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28911962/development-and-psychometric-validation-of-a-questionnaire-to-evaluate-nurses-adherence-to-recommendations-for-preventing-pressure-ulcers-qarppu
#20
Ana Belén Moya-Suárez, José Miguel Morales-Asencio, Marta Aranda-Gallardo, Margarita Enríquez de Luna-Rodríguez, José Carlos Canca-Sánchez
AIM OF THE STUDY: The main objective of this work is the development and psychometric validation of an instrument to evaluate nurses' adherence to the main recommendations issued for preventing pressure ulcers. MATERIAL AND METHODS: An instrument was designed based on the main recommendations for the prevention of pressure ulcers published in various clinical practice guides. Subsequently, it was proceeded to evaluate the face and content validity of the instrument by an expert group...
September 5, 2017: Journal of Tissue Viability
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