Read by QxMD icon Read


Ilan Gobius, Laura Morcom, Rodrigo Suárez, Jens Bunt, Polina Bukshpun, William Reardon, William B Dobyns, John L R Rubenstein, A James Barkovich, Elliott H Sherr, Linda J Richards
The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4,000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of callosal axons is dependent upon the prior remodeling and degradation of the intervening interhemispheric fissure. This remodeling event is initiated by astroglia on either side of the interhemispheric fissure, which intercalate with one another and degrade the intervening leptomeninges...
October 11, 2016: Cell Reports
Fariba Nikan, Mohammad Asghari Jafarabadi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Ali Montazeri, Sonia Asadi
BACKGROUND: There are some specific measures for the evaluation of postpartum quality of life, and each have some limitations. OBJECTIVES: This study investigated the validity and reliability of the Persian version of a postpartum women's quality of life (PQOL) questionnaire at the eighth week of postpartum. PATIENTS AND METHODS: This was a methodological research, and subjects were 500 women, ages 18 - 42, eight weeks postpartum, randomly selected from half of the public centers in Tabriz, Iran, who completed questionnaires in a self-administered manner...
July 2016: Iranian Red Crescent Medical Journal
Mayis Al-Dughmi, Catherine F Siengsukon
OBJECTIVES: The Neurological Fatigue Index (NFI-MS) is the only known perceived fatigue scale to include questions that consider the contribution of sleep quality to symptoms of fatigue in people with multiple sclerosis (MS). However, the relationship between the NFI-MS and sleep quality measures is unknown. This study aimed to explore the relationship between the NFI-MS and self-reported and objective sleep quality. Understanding the relationship between perceived fatigue and sleep quality measures could encourage a wider use of the NFI-MS in research and clinical settings...
September 16, 2016: Neurological Research
Dnika J Travis, Erica Leeanne Lizano, Michàlle E Mor Barak
The well-documented day-to-day and long-term experiences of job stress and burnout among employees in child welfare organisations increasingly raise concerns among leaders, policy makers and scholars. Testing a theory-driven longitudinal model, this study seeks to advance understanding of the differential impact of job stressors (work-family conflict, role conflict and role ambiguity) and burnout (emotional exhaustion and depersonalisation) on employee disengagement (work withdrawal and exit-seeking behaviours)...
June 2016: British Journal of Social Work
Tarun Narang, Arshdeep, Sunil Dogra
Nerve function impairment (NFI) in leprosy may occur and progress despite multidrug therapy alone or in combination with corticosteroids. We observed improvement in neuritis when minocycline was administered in patients with type 2 lepra reaction. This prompted us to investigate the role of minocycline in recent onset NFI, especially in corticosteroid unresponsive leprosy patients. Leprosy patients with recent onset clinical NFI (<6 months), as determined by Monofilament Test (MFT) and Voluntary Muscle Test (VMT), were recruited...
August 23, 2016: Dermatologic Therapy
Yan Teng, Junming Miao, Xiaofei Shen, Xiaolong Yang, Xinyuan Wang, Laibin Ren, Xiaoying Wang, Junli Chen, Jingyu Li, Shanze Chen, Yi Wang, Ning Huang
Micro-RNAs (miRNAs) critically regulate several host defense mechanisms, but their roles in the bacteria-epithelium interplay remain unclear. Our results displayed that the expression of miR-155 and miR-23a were down-regulated in K. pneumoniae-infected pulmonary epithelial cells. The elevated bacterial adhesion on A549 cells followed the enhancement of the cellular levels of these two miRNAs. Meanwhile, a mechanistic study demonstrated that miR-155 promoted integrin α5β1 function and resulted in the increased actin polymerization...
2016: Scientific Reports
Jun-cheng Chen, Yu-ruo Yan, Li Ai, Xue-hua Guo, Jian-xiu He, Ping Yuan
OBJECTIVE: To develop a questionnaire measuring sexual mental health of Tibetan university students. METHODS: A draft questionnaire was developed with reference to the Sexual Civilization Survey for University Students of New Century and other published literature, and in consultation with experts. The questionnaire was tested in 230 students. Exploratory factor analyses with principal component and varimax orthogonal rotation were performed. Common factors with a > 1 eigenvalues and ≥ 3 loaded items (factor loading ≥ 0...
May 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Wanderson Roberto Silva, David Costa, Filipa Pimenta, João Maroco, Juliana Alvares Duarte Bonini Campos
The objectives of this study were to develop a unified Portuguese-language version, for use in Brazil and Portugal, of the Body Shape Questionnaire (BSQ) and to estimate its validity, reliability, and internal consistency in Brazilian and Portuguese female university students. Confirmatory factor analysis was performed using both original (34-item) and shortened (8-item) versions. The model's fit was assessed with χ²/df, CFI, NFI, and RMSEA. Concurrent and convergent validity were assessed. Reliability was estimated through internal consistency and composite reliability (α)...
July 21, 2016: Cadernos de Saúde Pública
Yingtao Li, Yingchun Zeng, Wei Zhu, Ying Cui, Jie Li
BACKGROUND: Antenatal maternal mental health problems have numerous consequences for the well-being of both mother and child. This study aimed to test and construct a pertinent model of antenatal depressive symptoms within the conceptual framework of a stress process model. METHODS: This study utilized a cross-sectional study design. INCLUSION CRITERIA: participants were adult women (18 years or older) having a healthy pregnancy, in their third trimester (the mean weeks gestation was 34...
2016: BMC Pregnancy and Childbirth
Gül Seçkin, Dale Yeatts, Susan Hughes, Cassie Hudson, Valarie Bell
BACKGROUND: The Internet, with its capacity to provide information that transcends time and space barriers, continues to transform how people find and apply information to their own lives. With the current explosion in electronic sources of health information, including thousands of websites and hundreds of mobile phone health apps, electronic health literacy is gaining an increasing prominence in health and medical research. An important dimension of electronic health literacy is the ability to appraise the quality of information that will facilitate everyday health care decisions...
2016: Journal of Medical Internet Research
Qais Alefan, Aseel Karasneh, Faris El-Dahiyat, Mohd Alshara, Dania Abu-Naser
BACKGROUND: Generic drugs are considered the best alternative for the originator brand drugs because they have the same quality, safety, and efficacy yet offered at considerbaly lower cost. Prior research has developed instrumentation to assess patients' perceptions of generic drugs; however, little has been done to translate these measures in other languages. OBJECTIVES: This study's aim was to translate and validate an Arabic version of the generic drug scale (GMS) in a Jordanian sample...
June 3, 2016: Research in Social & Administrative Pharmacy: RSAP
A G Actis, E Versino, B Brogliatti, T Rolle
PURPOSE: Aim of this retrospective, observational study is to describe features of a population sample, affected by primary open angle glaucoma (POAG) in order to evaluate damage progression on the basis of the emerged individual risk factors. METHODS: We included 190 caucasian patients (377 eyes), evaluating relationship between individual risk factors (explicative variables) and MD (Mean Deviation) of standard automated perimetry. We also considered the dependent variable NFI (Neural Fiber Index) of GDx scanning laser polarimetry...
2016: Open Ophthalmology Journal
Marta Sabater-Galindo, Daniel Sabater-Hernández, Salvador Ruiz de Maya, Miguel Angel Gastelurrutia, Fernando Martínez-Martínez, Shalom I Benrimoj
Professional pharmaceutical services may impact on patient's health behaviour as well as influence on patients' perceptions of the pharmacist image. The Health Belief Model predicts health-related behaviours using patients' beliefs. However, health beliefs (HBs) could transcend beyond predicting health behaviour and may have an impact on the patients' perceptions of the pharmacist image. This study objective was to develop and test a model that relates patients' HBs to patient's perception of the image of the pharmacist, and to assess if the provision of pharmacy services (Intervention group-IG) influences this perception compared to usual care (Control group)...
June 13, 2016: Psychology, Health & Medicine
Ming-Ming Lai, Shi-Ying Lein, Siok-Hwa Lau, Ming-Ling Lai
This paper empirically tested eight key features of WHO guidelines to age-friendly community by surveying 211 informal caregivers and 402 self-care adults (aged 45 to 85 and above) in Malaysia. We examined the associations of these eight features with active aging and social connectedness through exploratory and confirmatory factor analyses. A structural model with satisfactory goodness-of-fit indices (CMIN/df = 1.11, RMSEA = 0.02, NFI = 0.97, TLI = 1.00, CFI = 1.00, and GFI = 0.96) indicates that transportation and housing, community support and health services, and outdoor spaces and buildings are statistically significant in creating an age-friendly environment...
2016: Journal of Aging Research
Hongyan Wang, Di Wu, Xiaofeng Wang, Guang Chen, Yuanya Zhang, Weiming Yan, Xiaoping Luo, Meifang Han, Qin Ning
The protein inhibitor of activated STAT1 (PIAS1) plays important roles in regulating virusinduced chronic hepatitis, but the interaction between hepatitis B virus (HBV) and hPIAS1 is not clear. Our aim was to verify if HBV encoding proteins enhance the transcription of hPIAS1 and which cis-elements and transcription factors were involved in the mechanism. In order to do, so a series of molecular biological methods, along with functional and histological studies, were performed. We found that the HBV surface protein (HBs) enhanced hPIAS1 transcription through the activities of TAL1, E47, myogenin (MYOG), and NFI, dependent on the activation of p38MAPK and ERK signaling pathways in vitro, which might contribute to the ineffectiveness of treatment in CHB patients...
June 8, 2016: Biological Chemistry
Roohollah Askari, Mohammad Arab, Arash Rashidian, Ali Akbari-Sari, Seyed Mostafa Hosseini, Hojat Gharaee
BACKGROUND: Given the rapid pace of changes in community health needs and the mission of healthcare organizations to provide and promote the community's health, the growing need to increase health system responsiveness to people as a key element of observance and fulfillment of justice is felt more than ever. OBJECTIVES: This study was aimed at designing the native model of responsiveness for Iran and to validate the aspects of the proposed model. MATERIALS AND METHODS: Our study had a cross-sectional design and was a validation study performed in 2014...
March 2016: Iranian Red Crescent Medical Journal
A-Yu Popova, A N Kulichenko, O V Maletskaya, N F Vasilenko, L I Shaposhnikova, E S Kotenev, V M Dubyansky, A S Volynkina, Ya V Lisitskaya, I V Samarina, N A Penkovskaya, I L Evstafiev, N N Tovpinets, N V Tsapko, O A Belova, D S Agapitov, T N Samoded, A A Nadolny, I S Kovalenko, S N Yakunin, N K Shvarsalon, L S Zinich, S N Tikhonov, G I Lyamkin, I V Zharnikova, Yu M Evchenko
AIM: Analysis of epidemic manifestations of natural-foci infections (NFI), clarification of spectrum of their causative agents, determination of epizootic activity of natural foci in the Crimea Federal District (KFD). MATERIALS AND METHODS: Epizootologic examination of 10 administrative districts of KDF was carried out. 291 pools (2705 specimens) of ixodes ticks and 283 samples of organs of small mammals were studied by PCRmethod for the presence of DNA/RNA of causative agents of a number of NFI...
March 2016: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Hidemi Hashimoto, Satoko Yanagisawa
Japanese-Brazilians were the third largest immigrant group in Japan in 2011. Their health issues have caused concern, as their limited language made them vulnerable by hindering access to health services. Upon considering child health, mothers' health literacy (HL) is very important. This study aimed to develop a health literacy scale among Brazilian mothers (HLSBM) in Japan. Questionnaires in Portuguese were distributed to 1474 mothers from December 2011 to March 2012. Among 698 collected, 558 questionnaires were analyzed...
May 21, 2016: Health Promotion International
Mohammad Ali Soleimani, Nasim Bahrami, Ameneh Yaghoobzadeh, Hedieh Banihashemi, Hamid Sharif Nia, Ali Akbar Haghdoost
BACKGROUND: Due to increasing recognition of the importance of death anxiety for understanding human nature, it is important that researchers who investigate death anxiety have reliable and valid methodology to measure. The purpose of this study was to evaluate the validity and reliability of the Persian version of Templer Death Anxiety Scale (TDAS) in family caregivers of cancer patients. MATERIALS AND METHODS: A sample of 326 caregivers of cancer patients completed a 15-item questionnaire...
May 2016: Iranian Journal of Nursing and Midwifery Research
Ying Zhang, Yuanyuan Yang, Jing Lv, Yanbo Zhang
BACKGROUND: The aim of the study is to develop a specific patient-reported scale of liver cirrhosis according to the Patient Reported Outcome guidelines of the Food and Drug Administration (FDA), and to examine its capacity to fill gaps in this field. METHODS: A conceptual framework was developed and a preliminary item pool developed through literature review and interviews of 10 patients with liver cirrhosis. With the preliminary items, we performed a pilot survey that included a cognitive test with patients and interviews with experts; the focus was on content and language of the scale...
2016: Health and Quality of Life Outcomes
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"