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https://www.readbyqxmd.com/read/28167668/myeloid-specific-knockout-of-nfi-a-improves-sepsis-survival
#1
Melissa B McPeak, Dima Youssef, Danielle A Williams, Christopher Pritchett, Zhi Q Yao, Charles E McCall, Mohamed El Gazzar
Myeloid-derived suppressor cells (MDSCs) arise from myeloid progenitors and suppress both innate and adaptive immunity. MDSCs expand during the later phases of sepsis in mice, promote immunosuppression, and reduce survival. Here, we report that the myeloid differentiation-related transcription factor NFI-A controls MDSC expansion during sepsis and impacts survival. Unlike MDSCs, myeloid cells with conditional deletion of the Nfia normally differentiated into effector cells during sepsis, cleared infecting bacteria, and did not express immunosuppressive mediators...
February 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28165643/toward-inventory-based-estimates-of-soil-organic-carbon-in-forests-of-the-united-states
#2
G M Domke, C H Perry, B F Walters, L E Nave, C W Woodall, C W Swanston
Soil organic carbon (SOC) is the largest terrestrial carbon (C) sink on Earth; this pool plays a critical role in ecosystem processes and climate change. Given the cost and time required to measure SOC, and particularly changes in SOC, many signatory nations to the United Nations Framework Convention on Climate Change report estimates of SOC stocks and stock changes using default values from the Intergovernmental Panel on Climate Change or country-specific models. In the United States (US), SOC in forests is monitored by the national forest inventory (NFI) conducted by the Forest Inventory and Analysis (FIA) program within the US Department of Agriculture, Forest Service...
February 6, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28163183/a-femoral-common-vein-aneurysm-in-a-patient-with-neurofibromatosis-syndrome-type-1
#3
C Seinturier, S Blaise, F Thony, J L Magne, G Pernod
Neurofibromatosis type I (NFI), also called Von Recklinghausen disease, is an autosomal dominant disease secondary to a genetic mutation on the long arm of chromosome 17. This disorder affects neural crest cells. Cutaneous clinical forms are the most frequent with multiple benign skin neurofibromas, associated with café au lait skin spots and iris hamartomas. Vascular abnormalities in NF1 are rare but have also been well described. The most frequent abnormalities are characterized by arterial aneurysm degeneration, stenosis, and malformations...
February 2, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28152469/cross-cultural-adaptation-and-psychometric-properties-of-the-korean-scale-for-internet-addiction-k-scale-in-japanese-high-school-students
#4
Kwok-Kei Mak, JeeEun Karin Nam, Dongil Kim, Narae Aum, Jung-Seok Choi, Cecilia Cheng, Huei-Chen Ko, Hiroko Watanabe
The Korean Scale for Internet Addiction (K-Scale) was developed in Korea for assessing addictive internet behaviors. This study aims to adopt K-Scale and examine its psychometric properties in Japanese adolescents. In 2014, 589 (36.0% boys) high school students (Grade 10-12) from Japan completed a survey, including items of Japanese versions of K-Scale and Smartphone Scale for Smartphone Addiction (S-Scale). Model fit indices of the original four-factor structure, three-factor structure obtained from exploratory factor analysis (EFA), and improved two-factor structure of K-Scale were computed using confirmatory factor analysis, with internal reliability of included items reported...
January 19, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28142298/palm-oil-and-human-health-meeting-report-of-nfi-nutrition-foundation-of-italy-symposium
#5
Franca Marangoni, Claudio Galli, Andrea Ghiselli, Giovanni Lercker, Carlo La Vecchia, Claudio Maffeis, Carlo Agostoni, Donatella Ballardini, Ovidio Brignoli, Pompilio Faggiano, Rosalba Giacco, Claudio Macca, Paolo Magni, Giuseppe Marelli, Walter Marrocco, Vito Leonardo Miniello, Gian Francesco Mureddu, Nicoletta Pellegrini, Roberto Stella, Ersilia Troiano, Elvira Verduci, Roberto Volpe, Andrea Poli
The use of palm oil by the food industry is increasingly criticized, especially in Italy, for its purported negative effects on human health and environment. This paper summarizes the conclusions of a Symposium on this topic, gathered by the Nutrition Foundation of Italy, among experts representing a number of Italian Medical and Nutritional Scientific Societies. Toxicological and environmental issues were not considered. Participants agreed that: no evidence does exist on the specific health effects of palm oil consumption as compared to other saturated fatty acids-rich fats; the stereospecific distribution of saturated fatty acids in the triacylglycerol molecule of palm oil limits their absorption rate and metabolic effects; in agreement with International guidelines, saturated fatty acids intake should be kept <10% of total energy, within a balanced diet; within these limits, no effect of palm oil consumption on human health (and specifically on CVD or cancer risk) can be foreseen...
January 31, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28135037/anatomy-education-environment-measurement-inventory-a-valid-tool-to-measure-the-anatomy-learning-environment
#6
Siti Nurma Hanim Hadie, Asma' Hassan, Zul Izhar Mohd Ismail, Mohd Asnizam Asari, Aaijaz Ahmed Khan, Fazlina Kasim, Nurul Aiman Mohd Yusof, Husnaida Abdul Manan Sulong, Tg Fatimah Murniwati Tg Muda, Wan Nor Arifin, Muhamad Saiful Bahri Yusoff
Students' perceptions of the education environment influence their learning. Ever since the major medical curriculum reform, anatomy education has undergone several changes in terms of its curriculum, teaching modalities, learning resources, and assessment methods. By measuring students' perceptions concerning anatomy education environment, valuable information can be obtained to facilitate improvements in teaching and learning. Hence, it is important to use a valid inventory that specifically measures attributes of the anatomy education environment...
January 30, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28101476/psychometric-properties-of-the-persian-version-of-the-quality-of-life-in-epilepsy-inventory-in-the-later-life
#7
Abdolrahim Asadollahi, Laleh Fani Saberi, Ali Havasi, Mohammad-Hossein Kaveh
BACKGROUND AND PURPOSE: The reports indicate on the incidence of seizure disorder about 1.5 per cent of the normal elderly population. The Quality of Life in Epilepsy Inventory (QOLIE-31) has been pervasive simple tool to screen seizure in the busy neurophysiological settings and monitoring. It was constructed as self-administered tool in two formats, 89 and 31-items. To the reliability and validity of the QOLIE-31 across older adults in the southwest Iran and discuss its role in the detection of health-related quality of elderly patients with epilepsy...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28077834/-validity-and-reliability-of-korean-version-of-the-spiritual-care-competence-scale
#8
Mi Ja Chung, Youngrye Park, Young Eun
PURPOSE: The aim of this study was to examine the validity and reliability of the Korean Version of the Spiritual Care Competence Scale (K-SCCS). METHODS: A cross-sectional study design was used. The K-SCCS consisted of 26 questions to measure spiritual care competence of nurses. Participants, 228 nurses who had more than 3 years'experience as a nurse, completed the survey. Confirmatory factor analysis was used to examine the construct validity and correlations of K-SCCS and spiritual well-being (SWB) were used to examine the criterion validity of K-SCCS...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28076901/nuclear-factor-one-transcription-factors-as-epigenetic-regulators-in-cancer
#9
REVIEW
Mitchell Fane, Lachlan Harris, Aaron G Smith, Michael Piper
Tumour heterogeneity poses a distinct obstacle to therapeutic intervention. While the initiation of tumours across various physiological systems is frequently associated with signature mutations in genes that drive proliferation and bypass senescence, increasing evidence suggests that tumour progression and clonal diversity is driven at an epigenetic level. The tumour microenvironment plays a key role in driving diversity as cells adapt to demands during tumour growth, and is thought to drive certain subpopulations back to a stem cell-like state...
January 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28041969/needle-free-injection-of-vesicular-phospholipid-gels-a-novel-approach-to-overcome-an-administration-hurdle-for-semisolid-depot-systems
#10
Michaela Breitsamer, Gerhard Winter
Vesicular phospholipid gels (VPGs) are depot formulations for the sustained release of drugs which are characterized by a high amount of phospholipids in the formulation. They consist of physiological excipients only and therefore display high biocompatibility. Their manufacture is simple, cheap, solvent free and ideal for the processing of proteins and peptides because of the low stress on the molecule e.g. by elevated temperatures. One major hurdle of VPGs is their high viscosity which makes them hard to almost impossible to inject with conventional, thin needles used for subcutaneous administration...
December 29, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28011440/adaptation-to-nursing-home-the-role-of-leisure-activities-in-light-of-motivation-and-relatedness
#11
Emin Altintas, Giorgio De Benedetto, Karim Gallouj
Based on the motivational sequence described in Self-Determination Theory, this study explored the relationship between relatedness, motivation, adaptation and leisure in nursing homes. We formulated the hypothesis that the variables of the study would be found in an integrative mediational sequence: Participation in leisure activities→Relatedness→Self-determined motivation→Adaptation to nursing homes. Participants (N=112, mean age=84.17) were invited to complete questionnaires assessing these variables...
December 13, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27984242/impact-of-abuse-on-adjustment-and-chronic-pain-disability-a-structural-equation-model
#12
Swati Mehta, Danielle Rice, Alan Chan, Allan P Shapiro, Keith Sequeira, Robert W Teasell
INTRODUCTION/AIM: Sexual abuse, "state" and "trait" psychosocial factors, pain intensity, and pain related disability have been shown to be correlated among individuals with chronic pain. However, the interacting relationships between these factors is poorly understood. The current study aims to test model which examines the effect of abuse, "state" and "trait" psychosocial factors, and pain intensity on pain related disability among individuals with chronic pain. METHODS: 229 participants diagnosed with chronic pain were recruited from a specialist chronic pain hospital in London, Ontario...
December 15, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27965439/transcriptional-regulation-of-intermediate-progenitor-cell-generation-during-hippocampal-development
#13
Lachlan Harris, Oressia Zalucki, Ilan Gobius, Hannah McDonald, Jason Osinki, Tracey J Harvey, Alexandra Essebier, Diana Vidovic, Ivan Gladwyn-Ng, Thomas H Burne, Julian I Heng, Linda J Richards, Richard M Gronostajski, Michael Piper
During forebrain development, radial glia generate neurons through the production of intermediate progenitor cells (IPCs). The production of IPCs is a central tenet underlying the generation of the appropriate number of cortical neurons, but the transcriptional logic underpinning this process remains poorly defined. Here, we examined IPC production using mice lacking the transcription factor nuclear factor I/X (Nfix). We show that Nfix deficiency delays IPC production and prolongs the neurogenic window, resulting in an increased number of neurons in the postnatal forebrain...
December 15, 2016: Development
https://www.readbyqxmd.com/read/27935991/a-competency-model-for-clinical-physicians-in-china-a-cross-sectional-survey
#14
Zhuang Liu, Lei Tian, Qing Chang, Baozhi Sun, Yuhong Zhao
BACKGROUND: Around the world, regulatory bodies have taken the lead in determining the competencies required to become a physician. As a first step in addressing this project, it was decided to develop a set of core competencies that were unique to China and that might serve as a basis for medical education. The purpose of this paper was to construct a competency model for clinical physicians in China. METHODS: Data was collected using a cross-sectional survey of 6247 clinicians from seven administrative regions (31 provinces, autonomous regions and municipalities directly under the central government) in China...
2016: PloS One
https://www.readbyqxmd.com/read/27931889/validation-of-the-bangla-mindful-attention-awareness-scale
#15
Md Azharul Islam, Saleh Siddique
This study tested the reliability, validity and factor structure of the Bangla translated Mindful Attention Awareness Scale (MAAS). Three scales - the Bangla MAAS, the short form of health 36 (SF-36) and the Internet Addiction Test (IAT) - were applied to 519 university students (51.4% female). Ninety-two participants were retested over a two weeks period to examine test-retest reliability. Consistent with previous studies, the results of exploratory and confirmatory factor analyses showed a single factor solution for the Bangla MAAS (χ2/df=222...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27916683/factor-analyses-for-the-%C3%A3-rebro-musculoskeletal-pain-questionnaire-for-working-and-nonworking-patients-with-chronic-low-back-pain
#16
Remko Soer, Patrick Vroomen, Roy Stewart, Maarten Coppes, Patrick Stegeman, Pieter Dijkstra, Michiel Reneman
BACKGROUND CONTEXT: The Örebro Musculoskeletal Pain Questionnaire (ÖMPQ) has good psychometric properties to predict return to work in patients with acute low back pain. Although it is used in patients with chronic back pain and nonworkers, there is no evidence on the factor structure of the ÖMPQ in these populations. This is deemed an important prerequisite for future prediction studies. PURPOSE: This study aimed to analyze the factor structure of the ÖMPQ in working and nonworking patients with chronic back pain...
December 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27881653/microrna-373-facilitates-the-replication-of-porcine-reproductive-and-respiratory-syndrome-virus-by-its-negative-regulation-of-type-i-interferon-induction
#17
Jing Chen, Xibao Shi, Xiaozhuan Zhang, Aiping Wang, Li Wang, Yanyan Yang, Ruiguang Deng, Gai-Ping Zhang
: MicroRNAs (miRNAs) play an important role in the regulation of immune responses. Previous studies have indicated that dysregulating the miRNAs leads to the immunosuppression of porcine reproductive and respiratory syndrome virus (PRRSV). However, it is not clear how PRRSV regulates the expression of host miRNA, which may lead to immune escape or promote the replication of the virus. The present work suggests that PRRSV upregulated the expression of miR-373 through elevating the expression of specificity protein 1 (Sp1) in MARC-145 cells...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27878595/cell-type-specific-expression-of-nfix-in-the-developing-and-adult-cerebellum
#18
James Fraser, Alexandra Essebier, Richard M Gronostajski, Mikael Boden, Brandon J Wainwright, Tracey J Harvey, Michael Piper
Transcription factors from the nuclear factor one (NFI) family have been shown to play a central role in regulating neural progenitor cell differentiation within the embryonic and post-natal brain. NFIA and NFIB, for instance, promote the differentiation and functional maturation of granule neurons within the cerebellum. Mice lacking Nfix exhibit delays in the development of neuronal and glial lineages within the cerebellum, but the cell-type-specific expression of this transcription factor remains undefined...
November 23, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27831609/-psychometric-properties-of-the-third-version-of-family-adaptability-and-cohesion-evaluation-scales-faces-iii-a-study-of-peruvian-adolescents
#19
Juan Carlos Bazo-Alvarez, Oscar Alfredo Bazo-Alvarez, Jeins Aguila, Frank Peralta, Wilfredo Mormontoy, Ian M Bennett
Objetives.: Our aim was to evaluate the psychometric properties of the FACES-III among Peruvian high school students. Materials and Methods.: This is a psychometric cross-sectional study. A probabilistic sampling was applied, defined by three stages: stratum one (school), stratum two (grade) and cluster (section). The participants were 910 adolescent students of both sexes, between 11 and 18 years of age. The instrument was also the object of study: the Olson's FACES-III...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27821196/motivational-values-parental-influences-and-the-experience-of-discrimination-among-romanian-and-moroccan-young-immigrants-in-spain
#20
Pablo Espinosa, Miguel Clemente, Octavio Uña
This study examines the role that motivational values play in the experience of discrimination in young immigrants in Spain and how this role is mediated by parental values. Participants in the study were 193 dyads of pre-adolescent to young adult first and second generation immigrants and one of their parents. All participants were either of Moroccan or Romanian ascent, the two largest immigrant groups in Spain. The proposed SEM model had an adequate fit, χ2(2, N = 193) = 2.272, p = .321, RMSEA = .027, CFI = ...
November 8, 2016: Spanish Journal of Psychology
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