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https://www.readbyqxmd.com/read/28101476/psychometric-properties-of-the-persian-version-of-the-quality-of-life-in-epilepsy-inventory-in-the-later-life
#1
Abdolrahim Asadollahi, Laleh Fani Saberi, Ali Havasi, Mohammad-Hossein Kaveh
BACKGROUND AND PURPOSE: The reports indicate on the incidence of seizure disorder about 1.5 per cent of the normal elderly population. The Quality of Life in Epilepsy Inventory (QOLIE-31) has been pervasive simple tool to screen seizure in the busy neurophysiological settings and monitoring. It was constructed as self-administered tool in two formats, 89 and 31-items. To the reliability and validity of the QOLIE-31 across older adults in the southwest Iran and discuss its role in the detection of health-related quality of elderly patients with epilepsy...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28077834/-validity-and-reliability-of-korean-version-of-the-spiritual-care-competence-scale
#2
Mi Ja Chung, Youngrye Park, Young Eun
PURPOSE: The aim of this study was to examine the validity and reliability of the Korean Version of the Spiritual Care Competence Scale (K-SCCS). METHODS: A cross-sectional study design was used. The K-SCCS consisted of 26 questions to measure spiritual care competence of nurses. Participants, 228 nurses who had more than 3 years'experience as a nurse, completed the survey. Confirmatory factor analysis was used to examine the construct validity and correlations of K-SCCS and spiritual well-being (SWB) were used to examine the criterion validity of K-SCCS...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28076901/nuclear-factor-one-transcription-factors-as-epigenetic-regulators-in-cancer
#3
REVIEW
Mitchell Fane, Lachlan Harris, Aaron G Smith, Michael Piper
Tumour heterogeneity poses a distinct obstacle to therapeutic intervention. While the initiation of tumours across various physiological systems is frequently associated with signature mutations in genes that drive proliferation and bypass senescence, increasing evidence suggests that tumour progression and clonal diversity is driven at an epigenetic level. The tumour microenvironment plays a key role in driving diversity as cells adapt to demands during tumour growth, and is thought to drive certain subpopulations back to a stem cell-like state...
January 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28041969/needle-free-injection-of-vesicular-phospholipid-gels-a-novel-approach-to-overcome-an-administration-hurdle-for-semisolid-depot-systems
#4
Michaela Breitsamer, Gerhard Winter
Vesicular phospholipid gels (VPGs) are depot formulations for the sustained release of drugs which are characterized by a high amount of phospholipids in the formulation. They consist of physiological excipients only and therefore display high biocompatibility. Their manufacture is simple, cheap, solvent free and ideal for the processing of proteins and peptides because of the low stress on the molecule e.g. by elevated temperatures. One major hurdle of VPGs is their high viscosity which makes them hard to almost impossible to inject with conventional, thin needles used for subcutaneous administration...
December 29, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28011440/adaptation-to-nursing-home-the-role-of-leisure-activities-in-light-of-motivation-and-relatedness
#5
Emin Altintas, Giorgio De Benedetto, Karim Gallouj
Based on the motivational sequence described in Self-Determination Theory, this study explored the relationship between relatedness, motivation, adaptation and leisure in nursing homes. We formulated the hypothesis that the variables of the study would be found in an integrative mediational sequence: Participation in leisure activities→Relatedness→Self-determined motivation→Adaptation to nursing homes. Participants (N=112, mean age=84.17) were invited to complete questionnaires assessing these variables...
December 13, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27984242/impact-of-abuse-on-adjustment-and-chronic-pain-disability-a-structural-equation-model
#6
Swati Mehta, Danielle Rice, Alan Chan, Allan P Shapiro, Keith Sequeira, Robert W Teasell
INTRODUCTION/AIM: Sexual abuse, "state" and "trait" psychosocial factors, pain intensity, and pain related disability have been shown to be correlated among individuals with chronic pain. However, the interacting relationships between these factors is poorly understood. The current study aims to test model which examines the effect of abuse, "state" and "trait" psychosocial factors, and pain intensity on pain related disability among individuals with chronic pain. METHODS: 229 participants diagnosed with chronic pain were recruited from a specialist chronic pain hospital in London, Ontario...
December 15, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27965439/transcriptional-regulation-of-intermediate-progenitor-cell-generation-during-hippocampal-development
#7
Lachlan Harris, Oressia Zalucki, Ilan Gobius, Hannah McDonald, Jason Osinki, Tracey J Harvey, Alexandra Essebier, Diana Vidovic, Ivan Gladwyn-Ng, Thomas H Burne, Julian I Heng, Linda J Richards, Richard M Gronostajski, Michael Piper
During forebrain development, radial glia generate neurons through the production of intermediate progenitor cells (IPCs). The production of IPCs is a central tenet underlying the generation of the appropriate number of cortical neurons, but the transcriptional logic underpinning this process remains poorly defined. Here, we examined IPC production using mice lacking the transcription factor nuclear factor I/X (Nfix). We show that Nfix deficiency delays IPC production and prolongs the neurogenic window, resulting in an increased number of neurons in the postnatal forebrain...
December 15, 2016: Development
https://www.readbyqxmd.com/read/27935991/a-competency-model-for-clinical-physicians-in-china-a-cross-sectional-survey
#8
Zhuang Liu, Lei Tian, Qing Chang, Baozhi Sun, Yuhong Zhao
BACKGROUND: Around the world, regulatory bodies have taken the lead in determining the competencies required to become a physician. As a first step in addressing this project, it was decided to develop a set of core competencies that were unique to China and that might serve as a basis for medical education. The purpose of this paper was to construct a competency model for clinical physicians in China. METHODS: Data was collected using a cross-sectional survey of 6247 clinicians from seven administrative regions (31 provinces, autonomous regions and municipalities directly under the central government) in China...
2016: PloS One
https://www.readbyqxmd.com/read/27931889/validation-of-the-bangla-mindful-attention-awareness-scale
#9
Md Azharul Islam, Saleh Siddique
This study tested the reliability, validity and factor structure of the Bangla translated Mindful Attention Awareness Scale (MAAS). Three scales - the Bangla MAAS, the short form of health 36 (SF-36) and the Internet Addiction Test (IAT) - were applied to 519 university students (51.4% female). Ninety-two participants were retested over a two weeks period to examine test-retest reliability. Consistent with previous studies, the results of exploratory and confirmatory factor analyses showed a single factor solution for the Bangla MAAS (χ2/df=222...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27916683/factor-analyses-for-the-%C3%A3-rebro-musculoskeletal-pain-questionnaire-for-working-and-nonworking-patients-with-chronic-low-back-pain
#10
Remko Soer, Patrick Vroomen, Roy Stewart, Maarten Coppes, Patrick Stegeman, Pieter Dijkstra, Michiel Reneman
BACKGROUND CONTEXT: The Örebro Musculoskeletal Pain Questionnaire (ÖMPQ) has good psychometric properties to predict return to work in patients with acute low back pain. Although it is used in patients with chronic back pain and nonworkers, there is no evidence on the factor structure of the ÖMPQ in these populations. This is deemed an important prerequisite for future prediction studies. PURPOSE: This study aimed to analyze the factor structure of the ÖMPQ in working and nonworking patients with chronic back pain...
December 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27881653/microrna-373-facilitates-the-replication-of-porcine-reproductive-and-respiratory-syndrome-virus-by-its-negative-regulation-of-type-i-interferon-induction
#11
Jing Chen, Xibao Shi, Xiaozhuan Zhang, Aiping Wang, Li Wang, Yanyan Yang, Ruiguang Deng, Gai-Ping Zhang
: MicroRNAs (miRNAs) play an important role in the regulation of immune responses. Previous studies have indicated that dysregulating the miRNAs leads to the immunosuppression of porcine reproductive and respiratory syndrome virus (PRRSV). However, it is not clear how PRRSV regulates the expression of host miRNA, which may lead to immune escape or promote the replication of the virus. The present work suggests that PRRSV upregulated the expression of miR-373 through elevating the expression of specificity protein 1 (Sp1) in MARC-145 cells...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27878595/cell-type-specific-expression-of-nfix-in-the-developing-and-adult-cerebellum
#12
James Fraser, Alexandra Essebier, Richard M Gronostajski, Mikael Boden, Brandon J Wainwright, Tracey J Harvey, Michael Piper
Transcription factors from the nuclear factor one (NFI) family have been shown to play a central role in regulating neural progenitor cell differentiation within the embryonic and post-natal brain. NFIA and NFIB, for instance, promote the differentiation and functional maturation of granule neurons within the cerebellum. Mice lacking Nfix exhibit delays in the development of neuronal and glial lineages within the cerebellum, but the cell-type-specific expression of this transcription factor remains undefined...
November 23, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27831609/-psychometric-properties-of-the-third-version-of-family-adaptability-and-cohesion-evaluation-scales-faces-iii-a-study-of-peruvian-adolescents
#13
Juan Carlos Bazo-Alvarez, Oscar Alfredo Bazo-Alvarez, Jeins Aguila, Frank Peralta, Wilfredo Mormontoy, Ian M Bennett
Objetives.: Our aim was to evaluate the psychometric properties of the FACES-III among Peruvian high school students. Materials and Methods.: This is a psychometric cross-sectional study. A probabilistic sampling was applied, defined by three stages: stratum one (school), stratum two (grade) and cluster (section). The participants were 910 adolescent students of both sexes, between 11 and 18 years of age. The instrument was also the object of study: the Olson's FACES-III...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27821196/motivational-values-parental-influences-and-the-experience-of-discrimination-among-romanian-and-moroccan-young-immigrants-in-spain
#14
Pablo Espinosa, Miguel Clemente, Octavio Uña
This study examines the role that motivational values play in the experience of discrimination in young immigrants in Spain and how this role is mediated by parental values. Participants in the study were 193 dyads of pre-adolescent to young adult first and second generation immigrants and one of their parents. All participants were either of Moroccan or Romanian ascent, the two largest immigrant groups in Spain. The proposed SEM model had an adequate fit, χ2(2, N = 193) = 2.272, p = .321, RMSEA = .027, CFI = ...
November 8, 2016: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/27760581/mental-health-literacy-as-a-mediator-in-use-of-mental-health-services-among-older-korean-adults
#15
Young Sun Kim, T Greg Rhee, Hee Yun Lee, Byung Hyun Park, Monica L Sharratt
BACKGROUND: Existing literature suggests that mental health literacy is positively associated with mental health services utilization. Despite an aging population that faces significant mental health concerns in Korea, the role of mental health literacy on mental health services utilization is not known among older adults in Korea. This study aimed to (1) identify whether mental health literacy mediates the association between population characteristics and mental health services utilization and (2) identify an optimal path model for mental health services utilization among Korean older adults...
October 20, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27732850/astroglial-mediated-remodeling-of-the-interhemispheric-midline-is-required-for-the-formation-of-the-corpus-callosum
#16
Ilan Gobius, Laura Morcom, Rodrigo Suárez, Jens Bunt, Polina Bukshpun, William Reardon, William B Dobyns, John L R Rubenstein, A James Barkovich, Elliott H Sherr, Linda J Richards
The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4,000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of callosal axons is dependent upon the prior remodeling and degradation of the intervening interhemispheric fissure. This remodeling event is initiated by astroglia on either side of the interhemispheric fissure, which intercalate with one another and degrade the intervening leptomeninges...
October 11, 2016: Cell Reports
https://www.readbyqxmd.com/read/27703799/psychometric-properties-of-the-iranian-version-of-a-postpartum-women-s-quality-of-life-questionnaire-pqol-a-methodological-study
#17
Fariba Nikan, Mohammad Asghari Jafarabadi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Ali Montazeri, Sonia Asadi
BACKGROUND: There are some specific measures for the evaluation of postpartum quality of life, and each have some limitations. OBJECTIVES: This study investigated the validity and reliability of the Persian version of a postpartum women's quality of life (PQOL) questionnaire at the eighth week of postpartum. PATIENTS AND METHODS: This was a methodological research, and subjects were 500 women, ages 18 - 42, eight weeks postpartum, randomly selected from half of the public centers in Tabriz, Iran, who completed questionnaires in a self-administered manner...
July 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27638459/the-relationship-between-sleep-quality-and-perceived-fatigue-measured-using-the-neurological-fatigue-index-in-people-with-multiple-sclerosis
#18
Mayis Al-Dughmi, Catherine F Siengsukon
OBJECTIVES: The Neurological Fatigue Index (NFI-MS) is the only known perceived fatigue scale to include questions that consider the contribution of sleep quality to symptoms of fatigue in people with multiple sclerosis (MS). However, the relationship between the NFI-MS and sleep quality measures is unknown. This study aimed to explore the relationship between the NFI-MS and self-reported and objective sleep quality. Understanding the relationship between perceived fatigue and sleep quality measures could encourage a wider use of the NFI-MS in research and clinical settings...
November 2016: Neurological Research
https://www.readbyqxmd.com/read/27559215/-i-m-so-stressed-a-longitudinal-model-of-stress-burnout-and-engagement-among-social-workers-in-child-welfare-settings
#19
Dnika J Travis, Erica Leeanne Lizano, Michàlle E Mor Barak
The well-documented day-to-day and long-term experiences of job stress and burnout among employees in child welfare organisations increasingly raise concerns among leaders, policy makers and scholars. Testing a theory-driven longitudinal model, this study seeks to advance understanding of the differential impact of job stressors (work-family conflict, role conflict and role ambiguity) and burnout (emotional exhaustion and depersonalisation) on employee disengagement (work withdrawal and exit-seeking behaviours)...
June 2016: British Journal of Social Work
https://www.readbyqxmd.com/read/27550711/minocycline-in-leprosy-patients-with-recent-onset-clinical-nerve-function-impairment
#20
Tarun Narang, Arshdeep, Sunil Dogra
Nerve function impairment (NFI) in leprosy may occur and progress despite multidrug therapy alone or in combination with corticosteroids. We observed improvement in neuritis when minocycline was administered in patients with type 2 lepra reaction. This prompted us to investigate the role of minocycline in recent onset NFI, especially in corticosteroid unresponsive leprosy patients. Leprosy patients with recent onset clinical NFI (<6 months), as determined by Monofilament Test (MFT) and Voluntary Muscle Test (VMT), were recruited...
August 23, 2016: Dermatologic Therapy
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