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Plin2 tnf

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https://www.readbyqxmd.com/read/27121253/reduced-circulating-levels-of-stweak-are-associated-with-nafld-and-may-affect-hepatocyte-triglyceride-accumulation
#1
J Lozano-Bartolomé, G Llauradó, M M Rodriguez, J M Fernandez-Real, J F Garcia-Fontgivell, J Puig, E Maymó-Masip, J Vendrell, M R Chacón
CONTEXT: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is strongly associated with obesity, dyslipidaemia and altered glucose regulation. Previous data demonstrated that low circulating levels of tumour necrosis factor weak inducer of apoptosis (sTWEAK) were associated with obesity, diabetes and insulin resistance, all traits associated with an increased risk of NALFD. Circulating sTWEAK levels are expected to be reduced in the presence of NAFLD...
September 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26968211/liver-specific-loss-of-perilipin-2-alleviates-diet-induced-hepatic-steatosis-inflammation-and-fibrosis
#2
Charles P Najt, Subramanian Senthivinayagam, Mohammad B Aljazi, Kelly A Fader, Sandra D Olenic, Julienne R L Brock, Todd A Lydic, A Daniel Jones, Barbara P Atshaves
Hepatic inflammation and fibrosis are key elements in the pathogenesis of nonalcoholic steatohepatitis (NASH), a progressive liver disease initiated by excess hepatic lipid accumulation. Lipid droplet protein Perilipin 2 (Plin2) alleviates dietary-induced hepatic steatosis when globally ablated; however, its role in the progression of NASH remains unknown. To investigate this further, we challenged Plin2 liver-specific knockout mice (designated L-KO) and their respective wild-type (WT) controls with a methionine-choline-deficient (MCD) diet for 15 days to induce a NASH phenotype of increased hepatic triglyceride levels through impaired phosphatidylcholine (PC) synthesis and very-low-density lipoprotein (VLDL) secretion...
May 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/26968210/intestinal-inflammation-requires-foxo3-and-prostaglandin-e2-dependent-lipogenesis-and-elevated-lipid-droplets
#3
Sandra Heller, Chloe Cable, Harrison Penrose, Rania Makboul, Debjani Biswas, Maleen Cabe, Susan E Crawford, Suzana D Savkovic
Intestinal inflammation has been recently characterized by the dysregulation of lipids as metabolic and energy sources, revealing a novel feature of its pathophysiology. Because intracellular lipids, stored in dynamic lipid droplets (LDs), provide energy for cellular needs, we investigated whether they play a role in intestinal inflammation. In the inflamed intestine of mice, elevated LDs were found in colonic and infiltrating immune cells as shown by staining for the LD coat protein PLIN2 and for lipids with BODIPY...
May 15, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/26367267/pycnogenol-attenuates-the-release-of-proinflammatory-cytokines-and-expression-of-perilipin-2-in-lipopolysaccharide-stimulated-microglia-in-part-via-inhibition-of-nf-%C3%AE%C2%BAb-and-ap-1-activation
#4
Bin Fan, Sai-Hong Dun, Jian-Qiu Gu, Yang Guo, Shoichiro Ikuyama
Over activation of microglia results in the production of proinflammatory agents that have been implicated in various brain diseases. Pycnogenol is a patented extract from French maritime pine bark (Pinus pinaster Aiton) with strong antioxidant and anti-inflammatory potency. The present study investigated whether pycnogenol may be associated with the production of proinflammatory mediators in lipopolysaccharide-stimulated BV2 (mouse-derived) microglia. It was found that pycnogenol treatment was dose-dependently associated with significantly less release of nitricoxide (NO), TNF-α, IL-6 and IL-1β, and lower levels of intercellular adhesion molecule1 (ICAM-1) and perilipin 2 (PLIN2)...
2015: PloS One
https://www.readbyqxmd.com/read/22427949/perilipin-2-plin2-deficiency-does-not-increase-cholesterol-induced-toxicity-in-macrophages
#5
COMPARATIVE STUDY
Se-Hee Son, Young-Hwa Goo, Benny H Chang, Antoni Paul
Interventions on macrophages/foam cells to redirect intracellular cholesterol towards efflux pathways could become a very valuable addition to our therapeutic arsenal against atherosclerosis. However, certain manipulations of the cholesteryl ester cycle, such as the inhibition of ACAT1, an ER-resident enzyme that re-esterifies cholesterol, are not well tolerated. Previously we showed that targeting perilipin-2 (PLIN2), a major lipid droplet (LD)-associated protein in macrophages, prevents foam cell formation and protects against atherosclerosis...
2012: PloS One
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