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https://www.readbyqxmd.com/read/28822992/low-dose-bisphenol-a-increases-bile-duct-proliferation-in-juvenile-rats-a-possible-evidence-for-risk-of-liver-cancer-in-the-exposed-population
#1
Ji Seong Jeong, Ki Taek Nam, Buhyun Lee, Aryo Dimas Pamungkas, Daeun Song, Minjeong Kim, Wook-Joon Yu, Jinsoo Lee, Sunha Jee, Youngja H Park, Kyung-Min Lim
Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females...
August 21, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28822978/ecological-analysis-of-secular-trends-in-low-birth-weight-births-and-adult-height-in-japan
#2
Naho Morisaki, Kevin Yuji Urayama, Keisuke Yoshii, S V Subramanian, Susumu Yokoya
BACKGROUND: Japan, which currently maintains the highest life expectancy in the world and has experienced an impressive gain in adult height over the past century, has suffered a dramatic twofold increase in low birth weight (LBW) births since the 1970s. METHODS: We observed secular trends in birth characteristics using 64 115 249 live births included the vital statistics (1969-2014), as well as trends in average height among 3 145 521 adults born between 1969 and 1996, included in 79 surveys conducted among a national, subnational or community population in Japan...
August 19, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28822925/accumulation-of-anticoagulant-rodenticides-chlorophacinone-bromadiolone-and-brodifacoum-in-a-non-target-invertebrate-the-slug-deroceras-reticulatum
#3
Hussein Alomar, André Chabert, Michael Coeurdassier, Danièle Vey, Philippe Berny
Anticoagulant rodenticides (ARs) are used worldwide to control populations of agricultural and urban rodents, but these pesticides may be accumulated in and poisoned non-target species of wildlife. Slugs may feed on rodenticide bait following field applications. Thus, it can be assumed that their predators are exposed to rodenticides through food chain transfer. However, AR exposure in the slugs has not been systematically studied. We investigated the accumulation of three ARs (chlorophacinone, bromadiolone or brodifacoum) in the slug Deroceras reticulatum exposed for a period of 5days followed by depuration time of 4days in the laboratory...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822562/underuse-of-effective-cardiac-medications-among-women-middle-aged-adults-and-racial-ethnic-minorities-with-coronary-artery-disease-from-the-national-health-and-nutrition-examination-survey-2005-to-2014
#4
Hoang V Tran, Molly E Waring, David D McManus, Nathaniel Erskine, Van T H Do, Catarina I Kiefe, Robert J Goldberg
Given the proven effectiveness of several cardiac medications for patients with coronary artery disease (CAD), we examined the national use of 4 classes of effective medications, overall and by age, sex, and race/ethnicity in 2005 to 2014. We used data from the National Health and Nutrition Examination Survey, including a self-reported diagnosis of CAD and independently verified medication use. Weighting procedures extrapolated our data to the adult US population with CAD. Analyses included 1,789 US adults aged ≥45 years with a history of CAD...
July 24, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28822544/performance-strategies-affect-mammary-gland-development-in-prepubertal-heifers
#5
R L Albino, A L Sguizzato, K M Daniels, M S Duarte, M M Lopes, S E F Guimarães, M M D C A Weller, M I Marcondes
In Brazil, the majority of dairy cattle are Holstein × Gyr (H×G). It is unknown whether excessive energy intake negatively affects their mammary development to the same extent as in purebred Holsteins. We hypothesized that mammary development of H×G heifers can be affected by dietary energy supply. We evaluated the effect of different average daily gains (ADG) achieved by feeding different amounts of a standard diet during the growing period on biometric measurements, development of mammary parenchyma (PAR) and mammary fat pad (MFP), and blood hormones...
August 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28822528/management-of-obesity-in-adult-asian-indians
#6
REVIEW
S Behl, A Misra
The prevalence of obesity in India is increasing and ranges from 8% to 38% in rural and 13% to 50% in urban areas. Obesity is a risk factor for development of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, coronary heart disease and many cancers. In Asian Indians excess abdominal and hepatic fat is associated with increased risk for T2DM and cardiovascular disease. There is higher risk for development of obesity related non-communicable diseases at lower body mass index levels, compared to white Caucasians...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822436/-development-of-anterior-fontanelle-in-chinese-children-in-2015
#7
Y Liu, H Li, Y Q Zhang, X N Zong
Objective: To observe the development of the anterior fontanel (AF) in healthy Chinese children from 1 to 36 months, and to assess the relationship between the closure of the AF and physical development in Chinese children. Method: This was a cross-sectional evaluation of the AF in a series of 104 147 healthy children between June 2015 and October 2015 from nine cities in China. The size and closure of AF of the children were measured and recorded, and the age for the closure of AF was calculated using probit analysis...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28822323/discriminative-clustering-on-manifold-for-adaptive-transductive-classification
#8
Zhao Zhang, Lei Jia, Min Zhang, Bing Li, Li Zhang, Fanzhang Li
In this paper, we mainly propose a novel adaptive transductive label propagation approach by joint discriminative clustering on manifolds for representing and classifying high-dimensional data. Our framework seamlessly combines the unsupervised manifold learning, discriminative clustering and adaptive classification into a unified model. Also, our method incorporates the adaptive graph weight construction with label propagation. Specifically, our method is capable of propagating label information using adaptive weights over low-dimensional manifold features, which is different from most existing studies that usually predict the labels and construct the weights in the original Euclidean space...
August 1, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28822046/body-mass-index-and-clinical-response-to-intravenous-or-subcutaneous-abatacept-in-patients-with-rheumatoid-arthritis
#9
Maria-Antonietta D'Agostino, Rieke Alten, Eduardo Mysler, Manuela Le Bars, June Ye, Bindu Murthy, Julia Heitzmann, Radu Vadanici, Gianfranco Ferraccioli
This post hoc analysis of ACQUIRE (NCT00559585) explored the effect of baseline body mass index (BMI) on the pharmacokinetics of and clinical response to subcutaneous (SC) or intravenous (IV) abatacept in patients with rheumatoid arthritis (RA). ACQUIRE was a phase 3b, 6-month, double-blind, double-dummy study in which patients with RA were randomized (1:1) to SC (fixed - dose; 125 mg/week) or IV (weight-tiered; ~ 10 mg/kg/month) abatacept plus methotrexate. In this analysis, minimum abatacept plasma concentration (Cmin) was measured at 3 and 6 months, and clinical remission over 6 months was assessed by Disease Activity Score 28 (C-reactive protein; DAS28 [CRP], < 2...
August 18, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28821993/segmentation-of-breast-ultrasound-images-based-on-active-contours-using-neutrosophic-theory
#10
Mahsa Lotfollahi, Masoumeh Gity, Jing Yong Ye, A Mahlooji Far
PURPOSE: Ultrasound imaging is an effective approach for diagnosing breast cancer, but it is highly operator-dependent. Recent advances in computer-aided diagnosis have suggested that it can assist physicians in diagnosis. Definition of the region of interest before computer analysis is still needed. Since manual outlining of the tumor contour is tedious and time-consuming for a physician, developing an automatic segmentation method is important for clinical application. METHODS: The present paper represents a novel method to segment breast ultrasound images...
August 18, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28821427/effects-of-different-strength-training-frequencies-on-maximum-strength-body-composition-and-functional-capacity-in-healthy-older-individuals
#11
Mari Turpela, Keijo Häkkinen, Guy Gregory Haff, Simon Walker
There is controversy in the literature regarding the dose-response relationship of strength training in healthy older participants. The present study determined training frequency effects on maximum strength, muscle mass and functional capacity over 6months following an initial 3-month preparatory strength training period. One-hundred and six 64-75year old volunteers were randomly assigned to one of four groups; performing strength training one (EX1), two (EX2), or three (EX3) times per week and a non-training control (CON) group...
August 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28821388/a-case-control-analysis-investigating-risk-factors-and-outcomes-for-nephrocalcinosis-and-renal-calculi-in-neonates
#12
Melissa Huynh, Roderick Clark, Jenny Li, Guido Filler, Sumit Dave
INTRODUCTION: Studies on outcomes and risk factors for neonatal nephrocalcinosis (NC) and renal calculi (RC) are limited, and often do not include controls for comparison. We conducted a case-control analysis to identify risk factors associated with NC and/or RC in neonates and studied the natural course of these anomalies. STUDY DESIGN: Infants diagnosed with NC/RC on ultrasound within the first year of life and corresponding gestational age- and gender-matched controls were identified from the neonatal intensive care unit database at our institution over a 10-year period...
July 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28821300/t1-refblochi-high-resolution-3d-post-contrast-t1-myocardial-mapping-based-on-a-single-3d-late-gadolinium-enhancement-volume-bloch-equations-and-a-reference-t1
#13
Chenxi Hu, Albert J Sinusas, Steffen Huber, Stephanie Thorn, Mitchel R Stacy, Hamid Mojibian, Dana C Peters
BACKGROUND: High resolution 3D T1 mapping is important for assessment of diffuse myocardial fibrosis in left atrium or other thin-walled structures. In this work, we investigated a fast single-TI 3D high resolution T1 mapping method that directly transforms a 3D late gadolinium enhancement (LGE) volume to a 3D T1 map. METHODS: The proposed method, T1-refBlochi, is based on Bloch equation modeling of the LGE signal, a single-point calibration, and assumptions that proton density and T2* are relatively uniform in the heart...
August 18, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28821183/improvement-of-the-threespine-stickleback-genome-using-a-hi-c-based-proximity-guided-assembly
#14
Catherine L Peichel, Shawn T Sullivan, Ivan Liachko, Michael A White
Scaffolding genomes into complete chromosome assemblies remains challenging even with the rapidly increasing sequence coverage generated by current next-generation sequence technologies. Even with scaffolding information, many genome assemblies remain incomplete. The genome of the threespine stickleback (Gasterosteus aculeatus), a fish model system in evolutionary genetics and genomics, is not completely assembled despite scaffolding with high-density linkage maps. Here, we first test the ability of a Hi-C based proximity-guided assembly (PGA) to perform a de novo genome assembly from relatively short contigs...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28820887/identification-of-putative-qtls-for-seedling-stage-phosphorus-starvation-response-in-finger-millet-eleusine-coracana-l-gaertn-by-association-mapping-and-cross-species-synteny-analysis
#15
M Ramakrishnan, S Antony Ceasar, K K Vinod, V Duraipandiyan, T P Ajeesh Krishna, Hari D Upadhyaya, N A Al-Dhabi, S Ignacimuthu
A germplasm assembly of 128 finger millet genotypes from 18 countries was evaluated for seedling-stage phosphorus (P) responses by growing them in P sufficient (Psuf) and P deficient (Pdef) treatments. Majority of the genotypes showed adaptive responses to low P condition. Based on phenotype behaviour using the best linear unbiased predictors for each trait, genotypes were classified into, P responsive, low P tolerant and P non-responsive types. Based on the overall phenotype performance under Pdef, 10 genotypes were identified as low P tolerants...
2017: PloS One
https://www.readbyqxmd.com/read/28820391/deep-brain-stimulation-alters-light-phase-food-intake-microstructure-in-rats
#16
P Prinz, P Kobelt, S Scharner, M Goebel-Stengel, D Harnack, K Faust, Y Winter, M Rose, A Stengel
Treatment of eating disorders like obesity or anorexia is challenging. Options are limited and new approaches desired. An interesting approach is the application of deep brain stimulation (DBS). The nucleus accumbens (NAcc) is part of the food reward system. A pilot study reported that DBS of the NAcc shell modulates food intake and body weight in rats. Underlying mechanisms such as the food intake microstructure are unknown so far. Normal weight female Sprague-Dawley rats were equipped with a custom-made DBS electrode placed unilaterally in the NAcc shell...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28820339/emergence-of-visceral-leishmaniasis-in-sri-lanka-a-newly-established-health-threat
#17
H V Y D Siriwardana, P Karunanayake, L Goonerathne, N D Karunaweera
BACKGROUND: Sri Lanka is a new focus of human cutaneous leishmaniasis caused by a genetic variant of usually visceralizing parasite Leishmania donovani. Over 3000 cases have been reported to our institution alone, during the past two decades. Recent emergence of visceral leishmaniasis is of concern. METHODS: Patients suspected of having visceral leishmaniasis (n = 120) fulfilling at least two of six criteria (fever > 2 weeks, weight loss, tiredness affecting daily functions, splenomegaly, hepatomegaly and anemia) were studied using clinic-epidemiological, immunological and haematological parameters...
August 18, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28820079/validation-of-a-system-for-monitoring-individual-feeding-and-drinking-behaviour-and-intake-in-young-cattle
#18
B R Oliveira, M N Ribas, F S Machado, J A M Lima, L F L Cavalcanti, M L Chizzotti, S G Coelho
The objective of this study was to validate an electronic system for monitoring individual feeding and drinking behaviour and intake developed for young cattle housed in group. A total of 35 Holstein-Gyr crossbred heifers (BW: 180±52 kg; age: 121.5±32.5 days), fitted with an ear tag containing a unique passive transponder, were distributed in three groups of 12, 12 and 11 animals per period and had free access to 12 electronic feed bins and two electronic water bins (Intergado® Ltd). The dimensions of feed and water bins, as well as the sensors position were appropriate for young cattle...
August 18, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28819983/an-evaluation-of-the-effectiveness-of-a-risk-based-monitoring-approach-implemented-with-clinical-trials-involving-implantable-cardiac-medical-devices
#19
Christopher A Diani, Angie Rock, Phil Moll
Background Risk-based monitoring is a concept endorsed by the Food and Drug Administration to improve clinical trial data quality by focusing monitoring efforts on critical data elements and higher risk investigator sites. BIOTRONIK approached this by implementing a comprehensive strategy that assesses risk and data quality through a combination of operational controls and data surveillance. This publication demonstrates the effectiveness of a data-driven risk assessment methodology when used in conjunction with a tailored monitoring plan...
August 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28819566/development-of-poly-lactic-glycolic-acid-plga-microspheres-for-controlled-release-of-rho-associated-kinase-inhibitor
#20
Sho Koda, Naoki Okumura, Junji Kitano, Noriko Koizumi, Yasuhiko Tabata
PURPOSE: The purpose of this study was to investigate the feasibility of poly lactic/glycolic acid (PLGA) as a drug delivery carrier of Rho kinase (ROCK) inhibitor for the treatment of corneal endothelial disease. METHOD: ROCK inhibitor Y-27632 and PLGA were dissolved in water with or without gelatin (W1), and a double emulsion [(W1/O)/W2] was formed with dichloromethane (O) and polyvinyl alcohol (W2). Drug release curve was obtained by evaluating the released Y-27632 by using high performance liquid chromatography...
2017: Journal of Ophthalmology
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