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serum uric acid and heart failure

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https://www.readbyqxmd.com/read/27916655/allopurinol-as-a-therapeutic-option-in-cardiovascular-disease
#1
REVIEW
Osita N Okafor, K Farrington, Diana A Gorog
Epidemiological studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disease. Alongside uric acid formation, increased xanthine oxidase activity also results in the formation of oxidative free radicals and superoxide particles. Oxidative stress significantly contributes to the development of cardiovascular disease, including endothelial cell dysfunction, atherosclerosis, vascular calcification and impaired myocardial energetics. Allopurinol, a competitive xanthine oxidase inhibitor, in addition to reducing serum uric acid levels, can act as a free radical scavenger...
December 1, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27865177/association-of-plasma-xanthine-oxidoreductase-activity-with-severity-and-clinical-outcome-in-patients-with-chronic-heart-failure
#2
Yoichiro Otaki, Tetsu Watanabe, Daisuke Kinoshita, Miyuki Yokoyama, Tetsuya Takahashi, Taku Toshima, Takayuki Sugai, Takayo Murase, Takashi Nakamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Isao Kubota
BACKGROUND: Oxidative stress due to purine degradation is associated with the development of chronic heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of purine degradation that plays a key role in uric acid (UA) production with a resultant increase in reactive oxygen species. However, the relationship between plasma XOR activity and CHF severity and clinical outcome remains unclear. METHODS AND RESULTS: We measured XOR activity in 440 patients with CHF and 44 control subjects...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27754083/os-19-06-change-of-blood-pressure-pattern-and-target-organ-damage-in-patients-with-chronic-kidney-disease-results-of-the-aprodite-2-study
#3
Ran-Hui Cha, Hajeong Lee, Jung Pyo Lee, Chun Soo Lim, Yon Su Kim, Sung Gyun Kim
OBJECTIVE: Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern change in hypertensive patients with CKD and its effects on target organ damages. DESIGN AND METHOD: We recruited 378 hypertensive CKD patients from 4 centers in Korea. They underwent office and ambulatory BP monitoring at the time of enrollment and 1 year after. High office and ambulatory BP was defined as > 140/90 mmHg and > 135/85 mmHg (daytime)/> 120/70 mmHg (nighttime), respectively...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27716206/association-of-serum-calcium-and-heart-failure-with-preserved-ejection-fraction-in-patients-with-type-2-diabetes
#4
Junfeng Li, Nan Wu, Wenling Dai, Liu Jiang, Yintao Li, Shibao Li, Zhongyuan Wen
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a recognized trigger factor for heart failure with preserved ejection fraction (HFpEF). Recent studies show that higher serum calcium level is associated with greater risk of both T2DM and heart failure. We speculate that increased serum calcium is related to HFpEF prevalence in patients with T2DM. METHODS: In this cross-sectional echocardiographic study, 807 normocalcemia and normophosphatemia patients with T2DM participated, of whom 106 had HFpEF...
October 3, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27672076/are-atherosclerotic-risk-factors-associated-with-a-poor-prognosis-in-patients-with-hyperuricemic-acute-heart-failure-the-evaluation-of-the-causal-dependence-of-acute-heart-failure-and-hyperuricemia
#5
Hirotake Okazaki, Akihiro Shirakabe, Nobuaki Kobayashi, Noritake Hata, Takuro Shinada, Masato Matsushita, Yoshiya Yamamoto, Yusaku Shibata, Junsuke Shibuya, Reiko Shiomura, Suguru Nishigoori, Kuniya Asai, Wataru Shimizu
Atherosclerosis induces the elevation of uric acid (UA), and an elevated UA level is well known to lead to a poor prognosis in patients with acute heart failure (AHF). However, the prognostic value of atherosclerotic risk factors in hyperuricemic AHF patients remains to be elucidated. The data from 928 patients who were admitted to the intensive care unit (ICU) at Nippon Medical School Chiba Hokusoh Hospital between January 2001 and December 2014, and whose serum UA levels were measured were screened. A total of 394 AHF patients with hyperuricemia were enrolled in this study...
September 26, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27643008/os-19-06-change-of-blood-pressure-pattern-and-target-organ-damage-in-patients-with-chronic-kidney-disease-results-of-the-aprodite-2-study
#6
Ran-Hui Cha, Hajeong Lee, Jung Pyo Lee, Chun Soo Lim, Yon Su Kim, Sung Gyun Kim
OBJECTIVE: Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern change in hypertensive patients with CKD and its effects on target organ damages. DESIGN AND METHOD: We recruited 378 hypertensive CKD patients from 4 centers in Korea. They underwent office and ambulatory BP monitoring at the time of enrollment and 1 year after. High office and ambulatory BP was defined as > 140/90 mmHg and > 135/85 mmHg (daytime)/> 120/70 mmHg (nighttime), respectively...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27568644/an-impaired-metabolism-of-nucleotides-underpins-a-novel-mechanism-of-cardiac-remodeling-leading-to-huntington-s-disease-related-cardiomyopathy
#7
Marta Toczek, Daniel Zielonka, Paulina Zukowska, Jerzy T Marcinkowski, Ewa Slominska, Mark Isalan, Ryszard T Smolenski, Michal Mielcarek
Huntington's disease (HD) is mainly thought of as a neurological disease, but multiple epidemiological studies have demonstrated a number of cardiovascular events leading to heart failure in HD patients. Our recent studies showed an increased risk of heart contractile dysfunction and dilated cardiomyopathy in HD pre-clinical models. This could potentially involve metabolic remodeling, that is a typical feature of the failing heart, with reduced activities of high energy phosphate generating pathways. In this study, we sought to identify metabolic abnormalities leading to HD-related cardiomyopathy in pre-clinical and clinical settings...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27541294/sglt2-inhibitors-benefit-risk-balance
#8
REVIEW
André J Scheen
Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycemia by increasing urinary glucose excretion. They have been evaluated in patients with type 2 diabetes treated with diet/exercise, metformin, dual oral therapy or insulin. Three agents are available in Europe and the USA (canagliflozin, dapagliflozin, empagliflozin) and others are commercialized in Japan or in clinical development. SGLT2 inhibitors reduce glycated hemoglobin, with a minimal risk of hypoglycemia. They exert favorable effects beyond glucose control with consistent body weight, blood pressure, and serum uric acid reductions...
October 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27292609/association-between-cardiac-renal-and-hepatic-biomarkers-and-outcomes-in-patients-with-acute-heart-failure
#9
Wing W Chan, Katherine Waltman Johnson, Howard S Friedman, Prakash Navaratnam
OBJECTIVES: Myocardial injury, worsening renal function, and hepatic impairment are independent risk factors for poor patient acute heart failure (AHF) outcomes. Biomarkers of organ damage may be useful in identifying patients at risk for poor outcomes. The objective of this analysis was to assess the relationship between abnormal AHF biomarkers and outcomes in AHF patients. METHODS: AHF admissions (N = 104,794) data from the Cerner Health Facts® inpatient database were analyzed retrospectively...
August 2016: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/27261247/the-prognostic-impact-of-uric-acid-in-patients-with-severely-decompensated-acute-heart-failure
#10
Hirotake Okazaki, Akihiro Shirakabe, Nobuaki Kobayashi, Noritake Hata, Takuro Shinada, Masato Matsushita, Yoshiya Yamamoto, Junsuke Shibuya, Reiko Shiomura, Suguru Nishigoori, Kuniya Asai, Wataru Shimizu
BACKGROUND: The serum level of uric acid (UA) is a well-known prognostic factor for heart failure (HF) patients. However, the prognostic impact of hyperuricemia and the factors that induce hyperuricemia in acute HF (AHF) patients are not well understood. METHODS AND RESULTS: Eight hundred eighty-nine AHF patients were enrolled in this study. The patients were assigned into a low UA group (UA≤7.0mg/dl, n=495) or a high UA group (UA>7.0mg/dl, n=394) according to their UA level on admission...
May 31, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27144905/prednisone-lowers-serum-uric-acid-levels-in-patients-with-decompensated-heart-failure-by-increasing-renal-uric-acid-clearance
#11
Chao Liu, Yuzhi Zhen, Qingzhen Zhao, Jian-Long Zhai, Kunshen Liu, Jian-Xin Zhang
Clinical studies have shown that large doses of prednisone could lower serum uric acid (SUA) in patients with decompensated heart failure (HF); however, the optimal dose of prednisone and underlying mechanisms are unknown. Thirty-eight patients with decompensated HF were randomized to receive standard HF care alone (n = 10) or with low-dose (15 mg/day, n = 8), medium-dose (30 mg/day, n = 10), or high-dose prednisone (60 mg/day, n = 10), for 10 days. At the end of the study, only high-dose prednisone significantly reduced SUA, whereas low- and medium-dose prednisone and standard HF care had no effect on SUA...
July 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27040576/prognostic-significance-of-hyperuricemia-in-patients-with-acute-heart-failure
#12
Alberto Palazzuoli, Gaetano Ruocco, Marco Pellegrini, Matteo Beltrami, Nicola Giordano, Ranuccio Nuti, Peter A McCullough
Serum uric acid (UA) is associated with death and hospitalization in chronic heart failure (HF). However, UA in acute HF has not been well studied with respect to its relation to renal dysfunction and vascular congestion. We measured admission serum UA along with baseline variables in 281 patients with acute HF screened from the Loop Diuretics Administration and Acute Heart Failure (Diur-HF) trial. Hyperuricemia was defined as serum UA >7 mg/dl in men and >6 mg/dl in women. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate <60 ml/min/1...
May 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26957281/allopurinol-ameliorates-cardiac-function-in-non-hyperuricaemic-patients-with-chronic-heart-failure
#13
J Xiao, S-B Deng, Q She, J Li, G-Y Kao, J-S Wang, Y Ma
OBJECTIVE: This study sought to observe the effects of allopurinol on the cardiac function of non-hyperuricaemic patients with chronic heart failure and determine the safety of allopurinol for clinical applications. PATIENTS AND METHODS: A group of 125 consecutive cases of non-hyperuricaemic patients with chronic heart failure who were treated at Chongqing Emergency Medical Centre between July 2011 and June 2012 were enrolled and were randomly divided into allopurinol (300 mg/day) group (n=62) and control group (n=63)...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26887218/serum-uric-acid-and-mortality-form-cardiovascular-disease-epoch-japan-study
#14
Wen Zhang, Hiroyasu Iso, Yoshitaka Murakami, Katsuyuki Miura, Masato Nagai, Daisuke Sugiyama, Hirotsugu Ueshima, Tomonori Okamura
AIM: To investigate the relationship between serum uric acid levels and cardiovascular disease in Asians. METHODS: We examined the above relationship using the data of Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN Study). The data of 36,313 subjects (15,628 men and 20,685 women aged 35-89 years without histories of stroke, coronary heart disease, or cancer at baseline) were used for the analyses. Sex-specific hazard ratios (HRs) of mortality from cardiovascular disease were estimated according to the quintiles of serum uric acid using Cox hazard models stratified by cohorts...
June 1, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/26774759/-prognostic-value-of-measuring-the-diameter-and-inspiratory-collapse-of-the-inferior-vena-cava-in-acute-heart-failure
#15
C Josa-Laorden, I Giménez-López, J Rubio-Gracia, F Ruiz-Laiglesia, V Garcés-Horna, J I Pérez-Calvo
OBJECTIVES: To assess the utility of measuring the diameter and collapse of the inferior vena cava (IVC) in acute heart failure (AHF), its relationship with the prognosis and serum biomarkers of congestion. PATIENTS AND METHODS: An observational prospective study was conducted that included 85 patients with AHF, classifying them into 4 groups according to IVC diameter (≤ or >20mm) and inspiratory collapse (< or ≥50%) at admission. The endpoints were mortality due to HF and the combined event of mortality and readmission for HF at 180 days...
May 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/26702277/clinical-and-laboratory-determinants-of-low-serum-level-of-25-hydroxyvitamin-d-during-escalation-of-pharmacotherapy-in-heart-failure-patients
#16
Krzysztof Myrda, Piotr Rozentryt, Jacek T Niedziela, Aneta Ociessa, Maria Kasperova, Bartosz Hudzik, Jolanta U Nowak, Mariusz Gąsior
INTRODUCTION: The activation of the renin-angiotensin-aldosterone (RAA) system is a main element of the pathophysiology of chronic heart failure (CHF), determining its symptoms and prognosis. Vitamin D is an RAA inhibitor, and its deficiency frequently accompanies CHF. The factors determining the concentration of 25-hydroxyvitamin D [25(OH)D] in CHF are not well understood, although an association has been suggested between the deficiency and the advancement of CHF. Also unknown is the influence of therapeutic escalation using recommended agents on the serum level of 25(OH)D...
September 2015: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/26660282/heart-failure-resulting-from-age-related-cardiac-amyloid-disease-associated-with-wild-type-transthyretin-a-prospective-observational-cohort-study
#17
Lawreen H Connors, Flora Sam, Martha Skinner, Francesco Salinaro, Fangui Sun, Frederick L Ruberg, John L Berk, David C Seldin
BACKGROUND: Heart failure caused by wild-type transthyretin amyloidosis (ATTRwt) is an underappreciated cause of morbidity and mortality in the aging population. The aims of this study were to examine features of disease and to characterize outcomes in a large ATTRwt cohort. METHODS AND RESULTS: Over 20 years, 121 patients with ATTRwt were enrolled in a prospective, observational study. Median age at enrollment was 75.6 years (range, 62.6-87.8 years); 97% of patients were white...
January 19, 2016: Circulation
https://www.readbyqxmd.com/read/26528453/the-association-of-subclinical-hypothyroidism-and-pattern-of-circulating-endothelial-derived-microparticles-among-chronic-heart-failure-patients
#18
Alexander E Berezin, Alexander A Kremzer, Yulia V Martovitskaya, Tatyana A Samura, Tatyana A Berezina
BACKGROUND: Subclinical hypothyroidism (SH) is diagnosed biochemically by the presence of normal serum free thyroxine concentration, in conjunction with an elevated serum thyroid-stimulating hormone level. Recent studies have demonstrated the frequent association between SH and cardiovascular diseases and risk factors. OBJECTIVES: To evaluate the impact of SH on patterns of circulating endothelial-derived microparticles, (EMPs) among chronic heart failure (CHF) patients...
November 2015: Research in Cardiovascular Medicine
https://www.readbyqxmd.com/read/26424212/serum-uric-acid-is-associated-with-mortality-and-heart-failure-hospitalizations-in-patients-with-complicated-myocardial-infarction-findings-from-the-high-risk-myocardial-infarction-database-initiative
#19
RANDOMIZED CONTROLLED TRIAL
Thomas G von Lueder, Nicolas Girerd, Dan Atar, Stefan Agewall, Zohra Lamiral, Mehmet Kanbay, Bertram Pitt, Kenneth Dickstein, Faiez Zannad, Patrick Rossignol
AIMS: Serum uric acid (SUA) levels are associated with poorer outcomes in healthy cohorts and patients with stable and unstable coronary heart disease. We investigated the relationship between SUA and clinical outcomes in subjects with acute myocardial infarction (MI) complicated by reduced left ventricular (LV) function, heart failure (HF), or both. METHODS AND RESULTS: Univariable and multivariable Cox proportional hazards modelling was performed to study the association of baseline SUA and all-cause mortality, cardiovascular (CV) mortality, and HF hospitalization in an individual patient meta-analysis of four merged large randomized trials (CAPRICORN, EPHESUS, OPTIMAAL, and VALIANT)...
November 2015: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26386814/uric-acid-lowering-therapy-in-cardiovascular-diseases
#20
Maurizio Volterrani, Ferdinando Iellamo, Barbara Sposato, Franco Romeo
Recent evidence would indicate that high serum uric acid (SUA) levels can be a significant and independent risk factor for hypertension and cardiovascular diseases, such as ischemic heart disease and heart failure. In the last few years an independent risk relationship between hyperuricemia, cardiovascular disease and mortality has also been reported. Hyperuricemia has been shown as an independent risk factor for acute myocardial infarction and an independent and conjoint association of either gout and SUA with total and cardiovascular mortality has been reported, with mortality impact in gout patients increasing with rising SUA concentrations, even for SUA levels in the normal to high range...
June 15, 2016: International Journal of Cardiology
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