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QRS morphology

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https://www.readbyqxmd.com/read/29774073/polypyrrole-chitosan-conductive-biomaterial-synchronizes-cardiomyocyte-contraction-and-improves-myocardial-electrical-impulse-propagation
#1
Zhi Cui, Nathan C Ni, Jun Wu, Guo-Qing Du, Sheng He, Terrence M Yau, Richard D Weisel, Hsing-Wen Sung, Ren-Ke Li
Background: The post-myocardial infarction (MI) scar interrupts electrical impulse propagation and delays regional contraction, which contributes to ventricular dysfunction. We investigated the potential of an injectable conductive biomaterial to restore scar tissue conductivity and re-establish synchronous ventricular contraction. Methods: A conductive biomaterial was generated by conjugating conductive polypyrrole (PPY) onto chitosan (CHI) backbones. Trypan blue staining of neonatal rat cardiomyocytes (CMs) cultured on biomaterials was used to evaluate the biocompatibility of the conductive biomaterials...
2018: Theranostics
https://www.readbyqxmd.com/read/29759777/the-impact-of-the-pr-interval-in-patients-receiving-cardiac-resynchronization-therapy-results-from-the-reverse-study
#2
Jeffrey Senfield, Claude Daubert, William T Abraham, Stefano Ghio, Martin St John Sutton, Jeffrey Cerkvenik, Cecilia Linde, Michael R Gold
OBJECTIVES: This study sought to evaluate the impact of baseline PR interval on cardiac resynchronization therapy (CRT) outcomes in the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) study. BACKGROUND: The baseline electrocardiogram has important prognostic value to determine response to CRT. Specifically, QRS duration and morphology are strong predictors of response and outcomes; however, the prognostic importance of the PR interval is less clear...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759535/utility-of-conventional-electrocardiographic-criteria-in-patients-with-idiopathic-ventricular-tachycardia
#3
Anil V Yadav, Babak Nazer, Barbara J Drew, John M Miller, Hicham El Masry, William J Groh, Andrea Natale, Nassir Marrouche, Nitish Badhwar, Yanfei Yang, Melvin M Scheinman
OBJECTIVES: This study sought to determine the ability of conventional electrocardiographic (ECG) criteria to correctly differentiate idiopathic ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy. BACKGROUND: Previously reported VT ECG criteria were developed from cohorts of patients with structural heart disease and have not been applied to patients with idiopathic VT. METHODS: ECGs of 115 idiopathic VTs, 101 post-myocardial infarction (MI) VTs, and 111 wide QRS SVTs were analyzed using standard criteria...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754992/the-utility-of-routine-clinical-12-lead-ecg-in-assessing-eligibility-for-subcutaneous-implantable-cardioverter-defibrillator
#4
Jason A Thomas, Erick Andres Perez-Alday, Christopher Hamilton, Muammar M Kabir, Eugene A Park, Larisa G Tereshchenko
INTRODUCTION: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a life-saving device. Recording of a specialized 3-lead electrocardiogram (ECG) is required for S-ICD eligibility assessment. The goals of this study were: (1) evaluate the effect of ECG filtering on S-ICD eligibility, and (2) simplify S-ICD eligibility assessment by development of an S-ICD ineligibility prediction tool, which utilizes the widely available routine 12-lead ECG. METHODS AND RESULTS: Prospective cross-sectional study participants [n = 68; 54% male; 94% white, with wide ranges of age (18-81 y), body mass index (19-53), QRS duration (66-150 ms), and left ventricular ejection fraction (37-77%)] underwent 12-lead supine, 3-lead supine and standing ECG recording...
May 8, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29744528/device-therapy-in-heart-failure-with-reduced-ejection-fraction-cardiac-resynchronization-therapy-and-more
#5
D Duncker, C Veltmann
In patients with heart failure with reduced ejection fraction (HFrEF), optimal medical treatment includes beta-blockers, ACE inhibitors/angiotensinreceptor-neprilysin inhibitors (ARNI), mineralocorticoid receptor antagonists, and ivabradine when indicated. In device therapy of HFrEF, implantable cardioverter-defibrillators and cardiac resynchronization therapy (CRT) have been established for many years. CRT is the therapy of choice (class I indication) in symptomatic patients with HFrEF and a broad QRS complex with a left bundle branch block (LBBB) morphology...
May 9, 2018: Herz
https://www.readbyqxmd.com/read/29742737/inadvertent-defibrillator-lead-placement-into-the-left-ventricle-after-mitraclip-implantation-a-case-report
#6
Giuseppe Santarpia, Francesco Passafaro, Eugenia Pasceri, Annalisa Mongiardo, Antonio Curcio, Ciro Indolfi
RATIONALE: Inadvertent pacemaker/defibrillator lead placement into the left ventricle is an unusual cardiac device-related complication and its diagnosis is not always easy and often misunderstood. Thromboembolic events are frequently associated with this procedural complication. Percutaneous lead extraction should be performed when diagnosis is made early after device implantation while long-life oral anticoagulation is a wise option when the diagnosis is delayed and the lead is not removed...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29731502/idiopathic-ventricular-premature-contraction-and-ventricular-tachycardia-distribution-of-the-origin-diagnostic-algorithm-and-catheter-ablation
#7
Yoshinori Kobayashi
Idiopathic ventricular premature contractions (VPCs), defined as VPCs in the absence of obvious structural heart disease, are one of the common types of arrhythmia in clinical practice. They are sometimes complicated with non-sustained ventricular tachycardia (VT), and/or sustained VT with almost same QRS morphology in 12 leads ECG. Idiopathic VT (IVT) commonly occurs by focal mechanisms and the origins are distributed in a variety of sites in both ventricles. In this article, the clinical characteristics of IVT/IVPCs, the diagnostic algorithm, and how to ablate them will be reviewed...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29728953/electrocardiography-based-prediction-of-hypertrophy-pattern-and-fibrosis-amount-in-hypertrophic-cardiomyopathy-comparative-study-with-cardiac-magnetic-resonance-imaging
#8
Chul Hwan Park, Hyemoon Chung, Yoonjung Kim, Jong-Youn Kim, Pil-Ki Min, Kyung-A Lee, Young Won Yoon, Tae Hoon Kim, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Although, cardiac magnetic resonance imaging (CMR) is a gold standard for risk stratification of hypertrophic cardiomyopathy (HCM), is limited in some situations. We sought to evaluate the predictive power of quantitative electrocardiography in assessing hypertrophy pattern and fibrosis in HCM. Eighty-eight patients with HCM were studied. Voltage of R-S-T waves, number of fragmented QRS (fQRS) complexes, and T wave morphology were measured by 12-lead electrocardiography. Sixteen segmental thickness, late gadolinium enhancement (LGE), native T1, extracellular volume fraction (ECV), and T2, left ventricular (LV) mass and %LGE were measured by CMR...
May 4, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29727501/a-wide-complex-tachycardia-with-atypical-right-bundle-branch-block-qrs-morphology-what-is-the-mechanism
#9
Tam Tsz Kin, Joseph Y S Chan, George J Klein
No abstract text is available yet for this article.
May 4, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29722042/bicarbonate-refractory-qrs-prolongation-and-left-bundle-branch-block-following-escitalopram-and-lamotrigine-overdose-a-case-report-and-literature-review-of-toxic-left-bundle-branch-block
#10
A N Farkas, M Marcott, J H Yanta, A F Pizon
WHAT IS KNOWN AND OBJECTIVE: Toxic prolongation of the QRS interval most often results from blockade of cardiac voltage-gated sodium channels and manifests on electrocardiogram with a right bundle-branch block-like morphology. Rarely, a left bundle-branch block (LBBB) morphology has been reported. CASE REPORT: We report a case of transient LBBB resultant from ingestion of lamotrigine and citalopram which was refractory to sodium bicarbonate therapy and eventually resolved spontaneously...
May 2, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29721674/use-of-the-wearable-cardioverter-defibrillator-wcd-and-wcd-based-remote-rhythm-monitoring-in-a-real-life-patient-cohort
#11
Maura M Zylla, Henrike A K Hillmann, Tanja Proctor, Meinhard Kieser, Eberhard Scholz, Edgar Zitron, Hugo A Katus, Dierk Thomas
The wearable cardioverter-defibrillator (WCD) was introduced to provide protection from sudden cardiac death (SCD) in patients with transiently elevated risk or during ongoing risk stratification. Benefits and clinical characteristics of routine WCD use remain to be assessed in larger patient populations. This study aims to identify determinants of WCD compliance, therapies, and inappropriate alarms in a real-life cohort. A total of 106 cases (68.9% male) were included between 11/2010 and 04/2016. WCD therapies, automatically recorded arrhythmia episodes, inappropriate WCD alarms, patient compliance, and outcome after WCD prescription were analyzed...
May 2, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29704608/comparison-of-one-and-three-lead-ecg-to-measure-cardiac-intervals-and-differentiate-drug-induced-multi-channel-block
#12
Robert Brockway, Marina Brockway, Brian Brockway, Robert Hamlin
INTRODUCTION: FDA has established initiatives to characterize clinical and non-clinical biomarkers to enable more precise prediction of proarrhythmia risk based upon knowledge of drug effect on multiple cardiac ion channels (Colatsky et al., 2016). The FDA has recently demonstrated superiority of early ventricular repolarization interval (JTp) in differentiating pure hERG block from multi-channel block in human subjects. Preclinical studies often acquire a single lead ECG, whereas FDA measurements of JTp were derived ​from a spatial vectorcardiogram computed using multiple leads...
April 25, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29689039/-electrocardiographic-diagnosis-when-qrs-is-wide
#13
Matilde Conti, Enrico Rino Bregani
Differential diagnosis of one or more wide QRS complexes on an electrocardiogram under emergency conditions takes into account three main sets of clinical conditions: ventricular pre-excitation, aberrant conduction and ventricular beats and it is based on the morphological analysis of the ECG and patient's anamnestic data. Several criteria can facilitate the differential diagnosis and if properly used and integrated with clinic data they can achieve good diagnostic accuracy in most cases. In this review several criteria based on evidence and literature are presented, paying attention in recognizing some morphologic pathways that can be used in emergency room and allow a correct ECG assessment...
April 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29687436/alexander-fractional-differential-window-filter-for-ecg-denoising
#14
Atul Kumar Verma, Indu Saini, Barjinder Singh Saini
The electrocardiogram (ECG) non-invasively monitors the electrical activities of the heart. During the process of recording and transmission, ECG signals are often corrupted by various types of noises. Minimizations of these noises facilitate accurate detection of various anomalies. In the present paper, Alexander fractional differential window (AFDW) filter is proposed for ECG signal denoising. The designed filter is based on the concept of generalized Alexander polynomial and the R-L differential equation of fractional calculus...
April 23, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29683541/an-interesting-case-of-narrow-qrs-tachycardia-with-incomplete-right-bundle-branch-block-morphology-what-is-the-mechanism
#15
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Hiren Kevadiya, Ajitkumar Valaparambil
No abstract text is available yet for this article.
April 23, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29676823/wide-qrs-tachycardia-with-right-bundle-branch-block-qrs-morphology-that-is-almost-identical-to-that-during-sinus-rhythm-what-is-the-mechanism
#16
Yasushi Wakabayashi, Takekuni Hayashi, Yoshitaka Sugawara, Takeshi Mitsuhashi, Hideo Fujita, Shin-Ichi Momomura
No abstract text is available yet for this article.
April 20, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29668588/a-delayed-diagnosis-of-catecholaminergic-polymorphic-ventricular-tachycardia-with-a-mutant-of-ryr2-at-c-7580t-g-for-6-years-in-a-9-year-old-child
#17
Hongyu Duan, Yongyi Lu, Song Yan, Lina Qiao, Yimin Hua, Yifei Li, Kaiyu Zhou, Chuan Wang
RATIONALE: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but potentially lethal inherited arrhythmia syndrome induced by adrenergic stress. Due to the atypical clinical manifestations in early age, limited recognition and experience of pediatric cardiologists, and low awareness of the significance of genetic diagnosis in some underdeveloped areas in China, a delayed or missed diagnosis of CPVT in children is common and concerning. PATIENT CONCERNS: A 9-year and 3-month male child with recurrent exercise-induced syncope accompanied by convulsion was initially misdiagnosed as epilepsy since the first manifestation at the age of 3 years...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29660191/in-vivo-human-sock-mapping-validation-of-a-simple-model-that-explains-unipolar-electrogram-morphology-in-relation-to-conduction-repolarization-dynamics
#18
Michele Orini, Peter Taggart, Pier D Lambiase
INTRODUCTION: The unipolar electrogram (UEG) provides local measures of cardiac activation and repolarization and is an important translational link between patient and laboratory. A simple theoretical model of the UEG was previously proposed and tested in-silico. METHOD AND RESULTS: The aim of this study was to use epicardial sock-mapping data to validate the simple model's predictions of unipolar electrogram morphology in the in-vivo human heart. The simple model conceptualizes the UEG as the difference between a local cardiac action potential and a position-independent component representing remote activity, which is defined as the average of all action potentials...
April 16, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29658207/ablation-induced-change-in-the-course-of-fascicular-tachycardia
#19
Avishag Laish-Farkash, Avi Sabbag, Michael Glikson, Aharon Glick, Vladimir Khalameizer, Amos Katz, Yoav Michowitz
BACKGROUND: Multiform fascicular tachycardia (FT) was recently described as a ventricular tachycardia (VT) that has a reentrant mechanism using multiple fascicular branches and produces alternate fascicular VT forms. Ablating the respective fascicle may cause a change in the reentrant circuit resulting in a change in morphology. Ablation of the septal fascicle is crucial for successful treatment. OBJECTIVES: To describe four cases of FT in which ablation induced a change in QRS morphologies and aggravated clinical course...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29628460/effect-of-qrs-morphology-and-duration-on-clinical-outcomes-after-cardiac-resynchronization-therapy-analysis-of-japanese-multicenter-registry
#20
Takafumi Oka, Koichi Inoue, Koji Tanaka, Yuko Hirao, Takaaki Isshiki, Takeshi Kimura, Masakiyo Nobuyoshi, Satoshi Shizuta, Takeshi Arita, Satoki Fujii, Katsuomi Iwakura, Kenshi Fujii, Kenji Ando
BACKGROUND: QRS duration (QRSd) and morphology are established response predictors of cardiac resynchronization therapy (CRT). However, evidence in Japanese populations is lacking.Methods and Results:We retrospectively analyzed the Japanese multicenter CRT database. We divided patients according to their intrinsic QRSd and morphology, and assessed echocardiographic responses and clinical outcomes. The primary endpoint was a composite of all-cause death or hospitalization because of heart failure...
April 7, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
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