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https://www.readbyqxmd.com/read/29317623/glp-1-release-and-vagal-afferent-activation-mediate-the-beneficial-metabolic-and-chronotherapeutic-effects-of-d-allulose
#1
Yusaku Iwasaki, Mio Sendo, Katsuya Dezaki, Tohru Hira, Takehiro Sato, Masanori Nakata, Chayon Goswami, Ryohei Aoki, Takeshi Arai, Parmila Kumari, Masaki Hayakawa, Chiaki Masuda, Takashi Okada, Hiroshi Hara, Daniel J Drucker, Yuichiro Yamada, Masaaki Tokuda, Toshihiko Yada
Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar D-allulose (D-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models. Subchronic D-allulose administered at the light period (LP) onset ameliorates LP-specific hyperphagia, visceral obesity, and glucose intolerance...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29316745/biotransformation-of-fructose-to-allose-by-one-pot-reaction-using-flavonifractor-plautii-d-allulose-3-epimerase-and-clostridium-thermocellumribose-5-phosphate-isomerase
#2
Tae-Eui Lee, Kyung-Chul Shin, Deok-Kun Oh
D-Allose is a potential medical sugar because it has anti-cancer, anti-hypertensive, anti-inflammatory, anti-oxidative, and immunosuppressant activities. Allose production from fructose as a cheap substrate was performed byone-pot reaction using Flavonifractor plautiiD-allulose 3-epimerase (FP-DAE) and Clostridium thermocellumribose 5-phosphate isomerase (CT-RPI). The optimal reaction conditions for allose production were pH 7.5, 60°C,0.1 g/l FP-DAE, 12 g/l CT-RPI, and 600 g/l fructose in the presence of 1 mM Co²⁺...
January 11, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29132732/the-role-of-artificial-and-natural-sweeteners-in-reducing-the-consumption-of-table-sugar-a-narrative-review
#3
REVIEW
Arshag D Mooradian, Meridith Smith, Masaaki Tokuda
The rapid increase in the prevalence of obesity worldwide has been partially attributed to the overconsumption of added sugars. Recent guidelines call for limiting the consumption of simple sugars to less than 10% of daily caloric consumption. High intensity sweeteners are regulated as food additives and include aspartame, acesulfame-k, neotame, saccharin, sucralose, cyclamate and alitame. Steviol glycosides and Luo Han Guo fruit extracts are high intensity sweeteners that are designated as generally recognized as safe (GRAS)...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29124517/characterization-of-l-rhamnose-isomerase-from-clostridium-stercorarium-and-its-application-to-the-production-of-d-allose-from-d-allulose-d-psicose
#4
Min-Ju Seo, Ji-Hyeon Choi, Su-Hwan Kang, Kyung-Chul Shin, Deok-Kun Oh
OBJECTIVE: To characterize L-rhamnose isomerase (L-RI) from the thermophilic bacterium Clostridium stercorarium and apply it to produce D-allose from D-allulose. RESULTS: A recombinant L-RI from C. stercorarium exhibited the highest specific activity and catalytic efficiency (k cat/K m) for L-rhamnose among the reported L-RIs. The L-RI was applied to the high-level production of D-allose from D-allulose. The isomerization activity for D-allulose was maximal at pH 7, 75 °C, and 1 mM Mn(2+) over 10 min reaction time...
November 9, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28988049/development-of-a-thermo-stable-and-recyclable-magnetic-nanobiocatalyst-for-bioprocessing-of-fruit-processing-residues-and-d-allulose-synthesis
#5
Satya Narayan Patel, Vishal Singh, Manisha Sharma, Rajender S Sangwan, Nitin K Singhal, Sudhir P Singh
The aim of the study was to covalently immobilize Smt3-D-psicose 3-epimerase onto functionalized iron oxide magnetic nanoparticles. After immobilization, Km of the immobilized enzyme increased, however, Vmax was nearly the same as that of its free form, indicating that immobilization has no detrimental effects on its catalytic output. The covalent immobilization caused a reduction in the deactivation rate constant (kd) values leading to 4-5 fold enhancement in its half-life at 50-65°C, indicating significant thermal stability of the iron-enzyme nanobioconjugate...
September 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28965946/d-allulose-a-stereoisomer-of-d-fructose-extends-caenorhabditis-elegans-lifespan-through-a-dietary-restriction-mechanism-a-new-candidate-dietary-restriction-mimetic
#6
Tomoya Shintani, Hirofumi Sakoguchi, Akihide Yoshihara, Ken Izumori, Masashi Sato
Dietary restriction (DR) is an effective intervention known to increase lifespan in a wide variety of organisms. DR also delays the onset of aging-associated diseases. DR mimetics, compounds that can mimic the effects of DR, have been intensively explored. d-Allulose (d-Alu), the C3-epimer of d-fructose, is a rare sugar that has various health benefits, including anti-hyperglycemia and anti-obesity effects. Here, we report that d-Alu increased the lifespan of Caenorhabditis elegans both under monoxenic and axenic culture conditions...
December 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28940418/rare-sugars-d-allulose-d-tagatose-and-d-sorbose-differently-modulate-lipid-metabolism-in-rats
#7
Yasuo Nagata, Narumi Mizuta, Akane Kanasaki, Kazunari Tanaka
BACKGROUND: Rare sugars including D-allulose, D-tagatose, and D-sorbose are present in limited quantities in nature; some of these rare sugars are now commercially produced using microbial enzymes. Apart from the anti-obesity and anti-hyperglycemic activities of D-allulose, effects of these sugars on lipid metabolism have not been investigated. Therefore, we aimed to determine if and how D-tagatose and D-sorbose modulate lipid metabolism in rats. After feeding these rare sugars to rats, parameters on lipid metabolism were determined...
September 21, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28935140/d-allulose-enhances-postprandial-fat-oxidation-in-healthy-humans
#8
Tomonori Kimura, Akane Kanasaki, Noriko Hayashi, Takako Yamada, Tetsuo Iida, Yasuo Nagata, Kazuhiro Okuma
OBJECTIVE: d-Allulose, a C-3 epimer of d-fructose, has been reported to decrease body weight and adipose tissue weight in animal studies and is expected to be a potent antiobese sweetener. Our animal study suggested that one of the mechanisms of d-allulose's antiobesity function is an increase in energy expenditure. However, a few studies have thus far explored the underlying mechanism in humans. The aim of this study was to examine the effects of a single ingestion of d-allulose on postprandial energy metabolism in healthy participants...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28924091/the-long-term-safety-of-d-allulose-administration-in-healthy-dogs
#9
Naohito Nishii, Satoshi Takashima, Yui Kobatake, Masaaki Tokuda, Hitoshi Kitagawa
The safety and biological effects of a long-term dose of D-allulose were evaluated in healthy dogs. For 12 weeks, the dogs were administered D-allulose (0.2 g/kg) or placebo daily. Plasma total cholesterol concentrations in the D-allulose group were significantly lower than those in the control group at and after week 2 (P<0.05). D-Allulose administration did not cause clinical signs or changes in hematological and biochemical levels, except for lipids. D-Allulose administration also did not influence body weight...
September 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28899486/immobilization-on-graphene-oxide-improves-the-thermal-stability-and-bioconversion-efficiency-of-d-psicose-3-epimerase-for-rare-sugar-production
#10
Samir R Dedania, Manisha J Patel, Dijit M Patel, Rekha C Akhani, Darshan H Patel
D-Psicose (D-ribo-2-hexulose or D-allulose), an epimer of D-fructose is considered as a rare low-calorie sugar displaying important physiological functions. Enzymatic production using ketose 3-epimerases is the feasible process for the production of D-Psicose. However, major drawbacks in application of ketose 3-epimerases are bioconversion efficiency and reusability of the enzyme. We have attempted immobilization of ketose 3-epimerases from Agrobacterium tumefaciens (agtu) D-psicose 3-epimerase (DPEase) on graphene oxide...
December 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28757536/comparison-of-anti-obesity-effect-between-two-types-of-syrup-containing-rare-sugars-in-wistar-rats
#11
Masaru Ochiai, Kohei Misaki, Takako Yamada, Tetsuo Iida, Kazuhiro Okuma, Tatsuhiro Matsuo
D-Allulose-containing rare sugar sweeteners have been categorized into two types, rare sugar syrup (RSS), consisting of 4 rare monosaccharides, and modified glucose syrup (MGS), rich in D-allulose, which was previously referred to D-psicose. The anti-obesity effect of RSS and D-allulose has been already clarified, but that of rare monosaccharides other than D-allulose in RSS has not yet been well understood. Here, we investigated and compared the anti-obesity effect of RSS and MGS in rats. Male Wistar rats were divided into 4 dietary groups: a high-sucrose control diet group (S), a high-fructose corn syrup diet group (HFCS), an RSS diet group (RSS), and an MGS diet group (MGS)...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28457550/effects-of-rare-sugar-d-allulose-on-acid-production-and-probiotic-activities-of-dairy-lactic-acid-bacteria
#12
H Kimoto-Nira, N Moriya, S Hayakawa, K Kuramasu, H Ohmori, S Yamasaki, M Ogawa
It has recently been reported that the rare sugar d-allulose has beneficial effects, including the suppression of postprandial blood glucose elevation in humans, and can be substituted for sucrose as a low-calorie food ingredient. To examine the applications of d-allulose in the dairy industry, we investigated the effects of d-allulose on the acid production of 8 strains of yogurt starter (Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus) and 4 strains of lactococci, including potential probiotic candidates derived from dairy products...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28417465/effects-of-rare-sugar-d-allulose-on-heat-induced-gelation-of-surimi-prepared-from-marine-fish
#13
Masahiro Ogawa, Masaki Inoue, Shigeru Hayakawa, Siwaporn O'Charoen, Makiko Ogawa
BACKGROUND: d-Allulose (Alu), the C3-epimer of d-fructose, is a non-caloric sweetener (0.39 kcal g(-1) ) with a suppressive effect on postprandial blood glucose elevation. The aim of this study was to investigate the effects of Alu used as a sweetener and gel improver instead of sucrose on heat-induced gelation of surimi. RESULTS: The puncture test of a heat-induced surimi gel showed that with 50 g kg(-1) Alu the gel had 15% and 6% higher gel strength than the corresponding gel with sucrose (Suc) and with sorbitol (Sor), respectively...
April 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28209058/rare-sugar-syrup-containing-d-allulose-but-not-high-fructose-corn-syrup-maintains-glucose-tolerance-and-insulin-sensitivity-partly-via-hepatic-glucokinase-translocation-in-wistar-rats
#14
Tomoya Shintani, Takako Yamada, Noriko Hayashi, Tetsuo Iida, Yasuo Nagata, Nobuaki Ozaki, Yukiyasu Toyoda
Ingestion of high-fructose corn syrup (HFCS) is associated with the risk of both diabetes and obesity. Rare sugar syrup (RSS) has been developed by alkaline isomerization of HFCS and has anti-obesity and anti-diabetic effects. However, the influence of RSS on glucose metabolism has not been explored. We investigated whether long-term administration of RSS maintains glucose tolerance and whether the underlying mechanism involves hepatic glucokinase translocation. Wistar rats were administered water, RSS, or HFCS in drinking water for 10 weeks and then evaluated for glucose tolerance, insulin tolerance, liver glycogen content, and subcellular distribution of liver glucokinase...
April 5, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28009059/production-of-d-allulose-from-d-glucose-by-escherichia-coli-transformant-cells-co-expressing-d-glucose-isomerase-and-d-psicose-3-epimerase-genes
#15
Wenli Zhang, Hao Li, Bo Jiang, Tao Zhang, Wanmeng Mu
BACKGROUND: d-Allulose is a novel and low-calorie rare monosaccharide that is a C-3 epimer of d-fructose. Because of its excellent physiological properties and commercial potential, d-allulose has attracted researchers' interests. Based on the Izumoring strategy, d-allulose is converted from d-fructose by d-psicose 3-epimerase (DPEase), while d-fructose is converted from d-glucose by d-glucose isomerase (GIase). In this study, we created a cellular system capable of converting d-glucose to d-allulose in a one-step process that co-expressed the GIase from Acidothermus cellulolyticus and the DPEase from Dorea sp...
December 23, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27870221/inductors-and-regulatory-properties-of-the-genomic-island-associated-fru2-metabolic-operon-of-streptococcus-agalactiae
#16
Kévin Patron, Philippe Gilot, Vanessa Rong, Aurélia Hiron, Laurent Mereghetti, Emilie Camiade
The fru2 metabolic operon of Streptococcus agalactiae encodes the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) enzyme II complex Fru2 (EIIB(Fru2) , EIIA(Fru2) , and EIIC(Fru2) ); Fru2 R, a transcriptional activator with PTS regulatory domains (PRDs); a d-allulose-6-phosphate 3-epimerase; a transaldolase; and a transketolase. We showed that the transcription of fru2 is induced during the stationary phase of growth in complex media and during incubation in human cerebrospinal or amniotic fluids...
February 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/27713017/purification-and-characterization-of-d-allulose-3-epimerase-derived-from-arthrobacter-globiformis-m30-a-gras-microorganism
#17
Akihide Yoshihara, Taro Kozakai, Tomoya Shintani, Ryo Matsutani, Kouhei Ohtani, Tetsuo Iida, Kazuya Akimitsu, Ken Izumori, Pushpa Kiran Gullapalli
An enzyme that catalyzes C-3 epimerization between d-fructose and d-allulose was found in Arthrobacter globiformis strain M30. Arthrobacter species have long been used in the food industry and are well-known for their high degree of safety. The enzyme was purified by ion exchange and hydrophobic interaction chromatographies and characterized as a d-allulose 3-epimerase (d-AE). The molecular weight of the purified enzyme was estimated to be 128 kDa with four identical subunits. The enzyme showed maximal activity and thermostability in the presence of Mg(2+)...
February 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/27598572/production-of-d-allulose-with-d-psicose-3-epimerase-expressed-and-displayed-on-the-surface-of-bacillus-subtilis-spores
#18
Weiwei He, Bo Jiang, Wanmeng Mu, Tao Zhang
The production of d-allulose is usually conducted via isolated-enzyme or whole-cell biocatalysis reactions. In the present study, an innovative biocatalyst, d-psicose 3-epimerase (DPEase) from Clostridium scindens ATCC 35704, presented on the surface of Bacillus subtilis spores, was applied for d-allulose production. DPEase was fused at the C-terminus of the anchoring protein, CotZ, via a peptide linker, and trophic genes were used as selection markers during the chromosomal integration. The optimal temperature and pH of the fusion protein CotZ-DPEase were 55 °C and pH 7...
September 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27467527/d-allulose-production-from-d-fructose-by-permeabilized-recombinant-cells-of-corynebacterium-glutamicum-cells-expressing-d-allulose-3-epimerase-flavonifractor-plautii
#19
Chul-Soon Park, Taeyong Kim, Seung-Hye Hong, Kyung-Chul Shin, Kyoung-Rok Kim, Deok-Kun Oh
A d-allulose 3-epimerase from Flavonifractor plautii was cloned and expressed in Escherichia coli and Corynebacterium glutamicum. The maximum activity of the enzyme purified from recombinant E. coli cells was observed at pH 7.0, 65°C, and 1 mM Co2+ with a half-life of 40 min at 65°C, Km of 162 mM, and kcat of 25280 1/s. For increased d-allulose production, recombinant C. glutamicum cells were permeabilized via combined treatments with 20 mg/L penicillin and 10% (v/v) toluene. Under optimized conditions, 10 g/L permeabilized cells produced 235 g/L d-allulose from 750 g/L d-fructose after 40 min, with a conversion rate of 31% (w/w) and volumetric productivity of 353 g/L/h, which were 1...
2016: PloS One
https://www.readbyqxmd.com/read/27452736/effects-of-d-allulose-on-glucose-metabolism-after-the-administration-of-sugar-or-food-in-healthy-dogs
#20
Naohito Nishii, Toru Nomizo, Satoshi Takashima, Tatsuya Matsubara, Masaaki Tokuda, Hitoshi Kitagawa
D-allulose is a C-3 epimer of D-fructose and has recently been investigated for its hypoglycemic effects. In the present study, the effects of D-allulose on glucose metabolism were evaluated in healthy dogs administrated sugar or food. The oral administrations of D-allulose decreased plasma glucose concentrations after oral glucose or maltose administration, with a diminished plasma insulin rise. The glucose suppressive effect of D-allulose was also observed after intravenous glucose administrations without increase in plasma insulin concentration...
December 1, 2016: Journal of Veterinary Medical Science
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