keyword
https://read.qxmd.com/read/38485054/furosemide-to-lower-antenatal-severe-hypertension-a-randomized-placebo-controlled-trial
#21
JOURNAL ARTICLE
Melanie M Maykin, Elizabeth Mercer, Kevin M Saiki, Bliss Kaneshiro, Corrie B Miller, Pai-Jong Stacy Tsai
BACKGROUND: Hypertensive disorders of pregnancy are a leading cause of perinatal morbidity, and timely treatment of severely elevated blood pressure is recommended to prevent serious sequelae. In acute hypertension marked by increased blood volume, it is unknown whether diuretics used as an adjunct to antihypertensive medications leads to more effective blood pressure control. OBJECTIVE: To evaluate whether the addition of intravenous furosemide to first-line antihypertensive agents reduces systolic blood pressure in acute-onset, severe antenatal hypertension with wide (≥60 mmgHg) pulse pressure...
March 12, 2024: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/38484654/altered-foot-placement-modulation-with-somatosensory-stimulation-in-people-with-chronic-stroke
#22
JOURNAL ARTICLE
Ethan B Schonhaut, Keith E Howard, Camden J Jacobs, Heather L Knight, Alyssa N Chesnutt, Jesse C Dean
Many individuals who experience a stroke exhibit reduced modulation of their mediolateral foot placement, an important gait stabilization strategy. One factor that may contribute to this deficit is altered somatosensory processing, which can be probed by applying vibration to the involved muscles (e.g., the hip abductors). The purpose of this study was to investigate whether appropriately controlled hip abductor vibration can increase foot placement modulation among people with chronic stroke. 40 people with chronic stroke performed a series of treadmill walking trials without vibration and with vibration of either the hip abductors or lateral trunk (a control condition) that scaled with their real-time mediolateral motion...
March 7, 2024: Journal of Biomechanics
https://read.qxmd.com/read/38483869/a-person-centred-care-transition-support-for-people-with-stroke-tia-a-study-protocol-for-effect-and-process-evaluation-using-a-non-randomised-controlled-design
#23
JOURNAL ARTICLE
Sebastian Lindblom, Maria Flink, Lena von Koch, Malin Tistad, Una Stenberg, Marie Elf, Axel C Carlsson, Ann Charlotte Laska, Charlotte Ytterberg
INTRODUCTION: Care transitions following a stroke call for integrated care approaches to reduce death and disability. The proposed research described in this study protocol aims to evaluate the effectiveness of a person-centred multicomponent care transition support and the process in terms of contextual moderators, implementation aspects and mechanisms of impact. METHODS: A non-randomized controlled trial design will be used. The intervention includes person-centred dialogue intended to permeate all patient-provider communication, various pedagogical modes of information, a person-centred care and rehabilitation plan, and a bridging e-meeting to prepare patients for homecoming...
2024: PloS One
https://read.qxmd.com/read/38483333/360%C3%A2-immersive-virtual-reality-based-mirror-therapy-for-upper-extremity-function-and-satisfaction-among-stroke-patients-a-randomized-controlled-trial
#24
JOURNAL ARTICLE
Sungbae Jo, Hoon Jang, Hyunjin Kim, Changho Song
BACKGROUND: Stroke is a leading cause of long-term disability worldwide; therefore, an effective rehabilitation strategy is fundamental. Mirror therapy (MT) has been a popular approach for upper extremity rehabilitation, but it presents some limitations. Recent advancements in virtual reality (VR) technology have introduced immersive VR-based MT, potentially overcoming these limitations and enhancing rehabilitation outcomes. AIM: This study aimed to evaluate the effectiveness of a novel 360° immersive virtual reality-based MT (360MT) in upper extremity rehabilitation for stroke patients, comparing it to traditional MT (TMT) and conventional physical therapy control group (CG)...
March 14, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38483332/repetitive-peripheral-magnetic-stimulation-for-preventing-shoulder-subluxation-after-stroke-a-randomized-controlled-trial
#25
JOURNAL ARTICLE
Kenta Fujimura, Hitoshi Kagaya, Ryoka Itoh, Chiharu Endo, Hiroki Tanikawa, Hirofumi Maeda
BACKGROUND: Shoulder subluxation caused by paralysis after stroke is a serious issue affecting shoulder pain and functional prognosis. However, its preventive treatment has not been fully investigated. AIM: To investigate the effects of repetitive peripheral magnetic stimulation (rPMS) on the prevention of shoulder subluxation. DESIGN: A single-center, parallel-group, prospective randomized, open-blinded, end-point study. SETTING: Convalescent rehabilitation ward...
March 14, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38482842/pemafibrate-and-other-triglyceride-lowering-therapies-to-reduce-risk-of-cardiovascular-and-metabolic-disease
#26
JOURNAL ARTICLE
Michael Miller
PURPOSE OF REVIEW: Although high triglycerides are consistently associated with elevated risk of cardiovascular disease (CVD), therapies that reduce triglyceride levels have inconsistently translated into reduced CVD risk. RECENT FINDINGS: To date, three clinical trials have tested triglyceride-lowering therapies in patients with hypertriglyceridemia (HTG) and elevated risk of incident/recurrent CVD. In REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial), assignment to IPE, a highly purified eicosapentanoic acid (EPA), resulted in a 25% reduction in nonfatal myocardial infarction), nonfatal stroke, cardiovascular death, coronary revascularization and hospitalization for unstable angina...
March 6, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38481943/effect-of-high-frequency-5hz-rtms-stimulating-left-dlpfc-combined-with-galantamine-on-cognitive-impairment-after-ischemic-stroke-and-serum-homocysteine-and-neuron-specific-enolase
#27
JOURNAL ARTICLE
Guojin Hu, Li Zhang, Xiuli Sun, Lin Wang, Qian Xu, Qin Li, Wei Huang, Yao Xiao
OBJECTIVE: To investigate the efficacy of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) combined with galantamine in patients with cognitive impairment after stroke and its effect on serum homocysteine (Hcy) and neuron-specific enolase (NSE) levels. METHODS: A total of 90 patients with cognitive impairment after the first ischemic stroke were enrolled. They were randomly divided into rTMS+ cognitive rehabilitation group, Galantamine + cognitive rehabilitation group, and rTMS+ Galantamine + cognitive rehabilitation group...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38481651/influenza-vaccines-may-protect-against-cardiovascular-diseases-the-evidence-is-mounting-and-should-be-known-by-the-canadian-public-health-community
#28
JOURNAL ARTICLE
Philippe De Wals, Michaël Desjardins
Evidence on the protective effect of influenza vaccines to prevent cardiovascular disease (CVD) is mounting. We identified 28 systematic reviews/meta-analyses on the effect of influenza vaccines on CVD using different research questions, data sources, selection criteria and outcomes. Most results leaned towards a protective effect. Results of recently published experimental and observational studies not included in these reviews were going in the same direction. The evidence is very robust for cardiovascular deaths and nonfatal myocardial infarction in high-risk individuals, but lower for heart failure, arrhythmia, and stroke and also for all outcomes in low-risk adults...
October 1, 2023: Canada Communicable Disease Report
https://read.qxmd.com/read/38481016/blood-pressure-after-successful-endovascular-therapy-a-systematic-review-and-meta-analysis-of-randomized-control-trials
#29
REVIEW
Khaled Gharaibeh, Nameer Aladamat, Adam T Mierzwa, Rahul Rao, Hisham Alhajala, Sami Al Kasab, Mohammad Anadani, Richard Burgess, Syed Zaidi, Mouhammad Jumaa
OBJECTIVE: There are limited data evaluating the optimum blood pressure (BP) goal post mechanical thrombectomy (MT) and its effect on outcomes of patients with large vessel occlusions (LVO). The objective of this study was to compare the efficacy and safety of intensive versus conventional BP control after reperfusion with MT via a systematic review and meta-analysis of randomized controlled trials (RCTs). METHODS: We searched PubMed and Embase to obtain articles related to BP control post MT through September 2023...
March 13, 2024: Annals of Neurology
https://read.qxmd.com/read/38480863/deep-learning-analysis-of-epicardial-adipose-tissue-to-predict-cardiovascular-risk-in-heavy-smokers
#30
JOURNAL ARTICLE
Borek Foldyna, Ibrahim Hadzic, Roman Zeleznik, Marcel C Langenbach, Vineet K Raghu, Thomas Mayrhofer, Michael T Lu, Hugo J W L Aerts
BACKGROUND: Heavy smokers are at increased risk for cardiovascular disease and may benefit from individualized risk quantification using routine lung cancer screening chest computed tomography. We investigated the prognostic value of deep learning-based automated epicardial adipose tissue quantification and compared it to established cardiovascular risk factors and coronary artery calcium. METHODS: We investigated the prognostic value of automated epicardial adipose tissue quantification in heavy smokers enrolled in the National Lung Screening Trial and followed for 12...
March 13, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38480608/outcome-and-risk-of-poststroke-pneumonia-in-patients-with-acute-ischemic-stroke-after-endovascular-thrombectomy-a-post-hoc-analysis-of-the-direct-mt-trial
#31
JOURNAL ARTICLE
Ping Zhang, Lei Chen, Xiao-Fei Ye, Tao Wu, Ben-Qiang Deng, Peng-Fei Yang, Yi Han, Yong-Wei Zhang, Jian-Min Liu
BACKGROUND: In this study, we aimed to investigate the risk factors and impact of poststroke pneumonia (PSP) on mortality and functional outcome in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). METHODS: This was a post hoc analysis of a prospective randomized trial (Direct intraarterial thrombectomy in order to revascularize AIS patients with large-vessel occlusion efficiently in Chinese tertiary hospitals: a multicenter randomized clinical trial)...
March 13, 2024: Neurocritical Care
https://read.qxmd.com/read/38479252/non-pharmacological-and-pharmacological-treatments-for-bone-health-after-stroke-systematic-review-with-meta-analysis
#32
REVIEW
Huixi Ouyang, Tsun C Lee, Faye Yf Chan, Xun Li, King Y Lai, Wing Y Lam, Tsz Y Yung, Marco Y C Pang
BACKGROUND: Hemi-osteoporosis is a common secondary complication of stroke. No systematic reviews of pharmacological and non-pharmacological agents for post-stroke bone health have estimated the magnitude and precision of effect sizes to guide better clinical practice. OBJECTIVES: To examine the benefits and harms of pharmacological and non-pharmacological agents on bone health in post-stroke individuals. METHODS: Eight databases were searched (PubMed, Cochrane library, Scopus, CINAHL Complete, Embase, PEDro, Clinicaltrils...
March 12, 2024: Annals of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38478535/impact-of-genetic-background-as-a-risk-factor-for-atherosclerotic-cardiovascular-disease-a-protocol-for-a-nationwide-genetic-case-control-cv-genes-study-in-brazil
#33
JOURNAL ARTICLE
Haliton Alves de Oliveira, Precil Diego Miranda de Menezes Neves, Gustavo Bernardes de Figueiredo Oliveira, Frederico Rafael Moreira, Maria Carolina Tostes Pintão, Viviane Zorzanelli Rocha, Cristiane de Souza Rocha, Viviane Nakano Katz, Elisa Napolitano Ferreira, Diana Rojas-Málaga, Celso Ferraz Viana, Fabiula Fagundes da Silva, Juliete Jorge Vidotti, Natalia Mariana Felicio, Leticia de Araújo Vitor, Karina Gimenez Cesar, Camila Araújo da Silva, Lucas Bassolli de Oliveira Alves, Álvaro Avezum
Atherosclerotic Cardiovascular Disease (ASCVD) represents the leading cause of death worldwide, and individual screening should be based on behavioral, metabolic, and genetic profile derived from data collected in large population-based studies. Due to the polygenic nature of ASCVD, we aimed to assess the association of genomics with ASCVD risk and its impact on the occurrence of acute myocardial infarction, stroke, or peripheral artery thrombotic-ischemic events at population level. CardioVascular Genes (CV-GENES) is a nationwide, multicenter, 1:1 case-control study of 3,734 patients in Brazil...
2024: PloS One
https://read.qxmd.com/read/38478165/cryoballoon-pulmonary-vein-isolation-as-first-line-treatment-of-typical-atrial-flutter-long-term-outcomes-of-the-craft-trial
#34
JOURNAL ARTICLE
Peter Calvert, Wern Yew Ding, Moloy Das, Lilith Tovmassian, Muzahir H Tayebjee, Guy Haywood, Claire A Martin, Kim Rajappan, Matthew G D Bates, Ian Peter Temple, Tobias Reichlin, Zhong Chen, Richard N Balasubramaniam, Christian Sticherling, Christina Ronayne, Nichola Clarkson, Maureen Morgan, Janet Barton, Ian Kemp, Saagar Mahida, Dhiraj Gupta
BACKGROUND: CRAFT was an international, multicentre, randomised controlled trial across 11 sites in the United UK and Switzerland. Given the evidence that pulmonary vein triggers may be responsible for atrial flutter (AFL) as well as atrial fibrillation (AF), we hypothesised that cryoballoon pulmonary vein isolation (PVI) would provide greater symptomatic arrhythmia reduction than cavotricuspid isthmus (CTI) ablation, whilst also reducing the subsequent burden of AF. Twelve-month outcomes were previously reported...
March 13, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://read.qxmd.com/read/38478042/optimal-folic-acid-dosage-in-lowering-homocysteine-precision-folic-acid-trial-to-lower-homocysteine-pfat-hcy
#35
JOURNAL ARTICLE
Xiao Huang, Huihui Bao, Congcong Ding, Junpei Li, Tianyu Cao, Lishun Liu, Yaping Wei, Ziyi Zhou, Nan Zhang, Yun Song, Ping Chen, Chongfei Jiang, Liling Xie, Xianhui Qin, Yan Zhang, Jianping Li, Ningling Sun, Genfu Tang, Xiaobin Wang, Hong Wang, Yong Huo, Xiaoshu Cheng
BACKGROUND: While folic acid (FA) is widely used to treat elevated total homocysteine (tHcy), promoting vascular health by reducing vascular oxidative stress and modulating endothelial nitric oxide synthase, the optimal daily dose and individual variation by MTHFR C677T genotypes have not been well studied. Therefore, this study aimed to explore the efficacy of eight different FA dosages on tHcy lowering in the overall sample and by MTHFR C677T genotypes. METHODS: This multicentered, randomized, double-blind, controlled clinical trial included 2697 eligible hypertensive adults with elevated tHcy (≥ 10 mmol/L) and without history of stroke and cardiovascular disease...
March 13, 2024: European Journal of Nutrition
https://read.qxmd.com/read/38477243/-advisability-of-carotid-endarterectomy-in-asymptomatic-patients
#36
JOURNAL ARTICLE
D A Korshunov, V A Kulbak, A V Chupin
OBJECTIVE: To determine the optimal treatment strategy for patients with asymptomatic carotid stenosis. MATERIAL AND METHODS: The authors reviewed clinical guidelines for the management of patients with asymptomatic carotid stenosis 60-99%, as well as medical studies and meta-analyses comparing carotid endarterectomy and optimal drug therapy in asymptomatic patients between 1993 and 2023. RESULTS: The choice of treatment strategy for patients with asymptomatic carotid artery stenosis is still a controversial issue...
2024: Khirurgiia
https://read.qxmd.com/read/38477109/rationale-of-the-inclusion-of-%C3%AE-blockers-among-major-antihypertensive-drugs-in-the-2023-european-society-of-hypertension-guidelines
#37
REVIEW
Giuseppe Mancia, Mattias Brunström, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Sverre E Kjeldsen, Maria L Muiesan, Costas Thomopoulos, Konstantinos Tsioufis, Reinhold Kreutz
We address the reasons why, unlike other guidelines, in the 2023 guidelines of the European Society of Hypertension β-blockers (BBs) have been regarded as major drugs for the treatment of hypertension, at the same level as diuretics, calcium channel blockers, and blockers of the renin-angiotensin system. We argue that BBs, (1) reduce blood pressure (the main factor responsible for treatment-related protection) not less than other drugs, (2) reduce pooled cardiovascular outcomes and mortality in placebo-controlled trials, in which there has also been a sizeable reduction of all major cause-specific cardiovascular outcomes, (3) have been associated with a lower global cardiovascular protection in 2 but not in several other comparison trials, in which the protective effect of BBs versus the other major drugs has been similar or even greater, with a slightly smaller or no difference of global benefit in large trial meta-analyses and a similar protective effect when comparisons extend to BBs in combination versus other drug combinations...
March 13, 2024: Hypertension
https://read.qxmd.com/read/38476746/efficacy-and-safety-of-transcranial-direct-current-stimulation-to-the-ipsilesional-motor-cortex-in-subacute-stroke-nets-a-multicenter-randomized-double-blind-placebo-controlled-trial
#38
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Each year, five million people are left disabled after stroke. Upper-extremity (UE) dysfunction is a leading problem. Neuroplasticity can be enhanced by non-invasive brain stimulation (NIBS) but evidence from large, randomized multicenter trials is lacking. We aimed at demonstrating efficacy of NIBS to enhance motor recovery after ischemic stroke. METHODS: We randomly assigned patients to receive anodal transcranial direct current (tDCS, 1 mA, 20 min) or placebo stimulation ('control') over the primary motor cortex of the lesioned hemisphere in addition to standardized rehabilitative training over ten days in the subacute phase after stroke...
March 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38476743/challenges-and-solutions-to-optimize-stroke-recovery-trial-enrollment-and-execution
#39
JOURNAL ARTICLE
Wuwei Feng, Nam-Jong Paik
No abstract text is available yet for this article.
March 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38473840/the-role-of-cilostazol-a-phosphodiesterase-3-inhibitor-in-the-development-of-atherosclerosis-and-vascular-biology-a-review-with-meta-analysis
#40
REVIEW
Minji Sohn, Soo Lim
Atherosclerotic cardiovascular disease (ASCVD) stands as the leading global cause of mortality. Addressing this vital and pervasive condition requires a multifaceted approach, in which antiplatelet intervention plays a pivotal role, together with antihypertensive, antidiabetic, and lipid-lowering therapies. Among the antiplatelet agents available currently, cilostazol, a phosphodiesterase-3 inhibitor, offers a spectrum of pharmacological effects. These encompass vasodilation, the impediment of platelet activation and aggregation, thrombosis inhibition, limb blood flow augmentation, lipid profile enhancement through triglyceride reduction and high-density lipoprotein cholesterol elevation, and the suppression of vascular smooth muscle cell proliferation...
February 23, 2024: International Journal of Molecular Sciences
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