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https://www.readbyqxmd.com/read/29912859/energetics-of-swimming-with-hand-paddles-of-different-surface-areas
#1
George H Crocker, Joseph F Moon, Jeff A Nessler, Sean C Newcomer
Crocker, GH, Moon, JF, Nessler, JA, and Newcomer, SC. Energetics of swimming with hand paddles of different surface areas. J Strength Cond Res XX(X): 000-000, 2018-Hand paddles are one of the most common training aids used by the competitive swimmer, yet little is known regarding how hand paddle surface area affects the metabolic cost of transport (COT) while swimming. The purpose of this study was to determine how altering hand paddle size affects energy use during submaximal, front-crawl (i.e., freestyle) swimming...
June 15, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29912422/age-and-outcomes-following-guided-de-escalation-of-antiplatelet-treatment-in-acute-coronary-syndrome-patients-undergoing-percutaneous-coronary-intervention-results-from-the-randomized-tropical-acs-trial
#2
Dirk Sibbing, Lisa Gross, Dietmar Trenk, Claudius Jacobshagen, Tobias Geisler, Martin Hadamitzky, Béla Merkely, Róbert Gábor Kiss, András Komócsi, Radoslaw Parma, Stephan B Felix, Franz-Josef Neumann, Jörg Hausleiter, Monika Baylacher, Lukasz Koltowski, Julinda Mehilli, Kurt Huber, Zenon Huczek, Dániel Aradi, Steffen Massberg
Aims: Guided de-escalation of P2Y12-inhibitor treatment was recently identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention. Safety and efficacy of this strategy may differ in relation to patient's age. This pre-specified analysis of the TROPICAL-ACS trial aimed to assess the impact of age on clinical outcomes following guided de-escalation of antiplatelet treatment in ACS patients. Methods and results: Patients were randomly assigned in a 1:1 fashion to either standard treatment with prasugrel for 12 months (control group) or to a guided de-escalation regimen (1 week prasugrel followed by 1 week clopidogrel and platelet function testing guided maintenance therapy with clopidogrel or prasugrel from day 14 after hospital discharge; guided de-escalation group)...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29912350/randomized-trial-of-ireadmore-word-reading-training-and-brain-stimulation-in-central-alexia
#3
Zoe V J Woodhead, Sheila J Kerry, Oscar M Aguilar, Yean-Hoon Ong, John S Hogan, Katerina Pappa, Alex P Leff, Jennifer T Crinion
Central alexia is an acquired reading disorder co-occurring with a generalized language deficit (aphasia). We tested the impact of a novel training app, 'iReadMore', and anodal transcranial direct current stimulation of the left inferior frontal gyrus, on word reading ability in central alexia. The trial was registered at www.clinicaltrials.gov (NCT02062619). Twenty-one chronic stroke patients with central alexia participated. A baseline-controlled, repeated-measures, crossover design was used. Participants completed two 4-week blocks of iReadMore training, one with anodal stimulation and one with sham stimulation (order counterbalanced between participants)...
June 15, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29912022/mental-practice-for-upper-limb-rehabilitation-after-stroke-a-systematic-review-and-meta-analysis
#4
Si-Woon Park, Jae-Hyung Kim, Yun-Jung Yang
Mental practice (MP) is usually provided in combination with other therapies, and new developments for neurofeedback to support MP have been made recently. The objectives of this study were to evaluate the effectiveness of MP and to investigate the intervention characteristics including neurofeedback that may affect treatment outcome. The Cochrane Central Register of Controlled Trials, PubMed, Embase, KoreaMed, Scopus, Web of Science, PEDro, and CIRRIE were searched from inception to March 2017 for randomized controlled trials to assess the effect of MP for upper limb rehabilitation after stroke...
June 14, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29911416/attention-control-comparisons-with-slt-for-people-with-aphasia-following-stroke-methodological-concerns-raised-following-a-systematic-review
#5
Marian C Brady, Jon Godwin, Helen Kelly, Pam Enderby, Andrew Elders, Pauline Campbell
OBJECTIVE: Attention control comparisons in trials of stroke rehabilitation require care to minimize the risk of comparison choice bias. We compared the similarities and differences in SLT and social support control interventions for people with aphasia. DATA SOURCES: Trial data from the 2016 Cochrane systematic review of SLT for aphasia after stroke Methods: Direct and indirect comparisons between SLT, social support and no therapy controls. We double-data extracted intervention details using the template for intervention description and replication...
June 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29910768/movement-sonification-in-stroke-rehabilitation
#6
Gerd Schmitz, Jeannine Bergmann, Alfred O Effenberg, Carmen Krewer, Tong-Hun Hwang, Friedemann Müller
Stroke often affects arm functions and thus impairs patients' daily activities. Recently, several studies have shown that additional movement acoustics can enhance motor perception and motor control. Therefore, a new method has been developed that allows providing auditory feedback about arm movement trajectories in real-time for motor rehabilitation after stroke. The present article describes the study protocol for a randomized, controlled, examiner, and patient blinded superiority trial (German Clinical Trials Register, www...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29910583/practical-perspectives-on-the-use-of-non-vitamin-k-antagonist-oral-anticoagulants-for-stroke-prevention-in-patients-with-nonvalvular-atrial-fibrillation-a-view-from-the-middle-east-and-north-africa
#7
REVIEW
Ahmad S Hersi, Yahya S Alhebaishi, Omar Hamoui, Taher Hassan, Adel Khalifa Hamad, Mohamed Magdy, Hani Sabbour, Sameh Shaheen
Clinical guidelines for the prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) are available from several international cardiology associations. Patients with NVAF in the Middle East and North Africa (MENA) region present unique challenges and opportunities related to differences in geography, practice patterns, and patient demographics that are as yet unaddressed in practice guidelines. This review aims to offer a practical perspective on the management of NVAF in patients in MENA and draws on evidence-based guidelines as well as real-world evidence and expert opinion...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29910194/odyssey-of-patent-foramen-ovale-closure-in-cryptogenic-stroke-the-canary-in-the-coal-mine-of-clinical-trials
#8
EDITORIAL
Sreekanth Vemulapalli, Manesh R Patel
No abstract text is available yet for this article.
June 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29910193/closure-anticoagulation-or-antiplatelet-therapy-for-cryptogenic-stroke-with-patent-foramen-ovale-systematic-review-of-randomized-trials-sequential-meta-analysis-and-new-insights-from-the-close-study
#9
REVIEW
Guillaume Turc, David Calvet, Patrice Guérin, Marjorie Sroussi, Gilles Chatellier, Jean-Louis Mas
BACKGROUND: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing patent foramen ovale (PFO) closure, anticoagulation, and antiplatelet therapy to prevent stroke recurrence in patients with PFO-associated cryptogenic stroke. METHODS AND RESULTS: We searched Medline, Cochrane Library, and EMBASE through March 2018. The primary outcome was stroke recurrence. Pooled incidences, hazard ratios, and risk ratios (RRs) were calculated in random-effects meta-analyses...
June 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29910060/revival-of-transcatheter-pfo-closure-a-meta-analysis-of-randomized-controlled-trials-impact-of-shunt-size-and-age
#10
REVIEW
Markus Reinthaler, Ann-Kathrin Ozga, David Sinning, Jonathan Curio, Haitham S Al-Hindwan, Johan Bäckemo Johansson, Friedrich Jung, Andreas Lendlein, Geraldine Rauch, Ulf Landmesser
BACKGROUND: Transcatheter foramen ovale closure (TPC) has emerged as a potential treatment option for patients with cryptogenic strokes and persistent foramen ovale (PFO). However, previous randomized controlled trials could hardly demonstrate any benefit compared to medical treatment (Med-Tx). Recently new data have become available which may change current practice of transcatheter PFO closure. METHODS: A systematic review and meta-analysis comparing TPC and Med-Tx based on all available multicentric randomized controlled trials was performed...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29910052/incidence-timing-and-type-of-first-and-recurrent-ischemic-events-in-patients-with-and-without-peripheral-artery-disease-after-an-acute-coronary-syndrome
#11
Taku Inohara, Karen Pieper, Daniel M Wojdyla, Manesh R Patel, William Schuyler Jones, Pierluigi Tricoci, Kenneth W Mahaffey, Stefan K James, John H Alexander, Renato D Lopes, Lars Wallentin, Erik Magnus Ohman, Matthew T Roe, Sreekanth Vemulapalli
BACKGROUND: Patients with peripheral artery disease (PAD) are known to have an increased risk of ischemic cardiovascular events. However, the influence of concomitant PAD on first and subsequent recurrent ischemic events after an acute coronary syndrome (ACS) remains poorly characterized. METHODS: We analyzed the combined data set from 4 randomized trials (PLATO, APPRAISE-2, TRA-CER, and TRILOGY ACS) in ACS for a follow-up length of 1 year. Using multivariable regression, we examined the association between PAD and major adverse cardiovascular events, a composite of cardiovascular death, myocardial infarction, and stroke...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909948/revascularization-strategies-in-cardiogenic-shock-complicating-acute-myocardial-infarction-a-systematic-review-and-meta-analysis
#12
Hammad Rahman, Safi U Khan, Ahmad N Lone, Edo Kaluski
BACKGROUND: The optimal revascularization strategy in patients with multi-vessel disease (MVD) presenting with acute myocardial infarction (AMI) and cardiogenic shock (CS) remains unclear. OBJECTIVE: To investigate the comparative differences between culprit-only revascularization (COR) versus instant multi-vessel revascularization (IMVR) in AMI and CS. METHODS: 13 studies were selected using MEDLINE, EMBASE and the CENTRAL (Inception - 31 November2017)...
June 9, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29909774/cardiovascular-magnetic-resonance-assessment-of-acute-cardiovascular-effects-of-voluntary-apnoea-in-elite-divers
#13
L Eichhorn, J Doerner, J A Luetkens, J M Lunkenheimer, R C Dolscheid-Pommerich, F Erdfelder, R Fimmers, J Nadal, B Stoffel-Wagner, H H Schild, A Hoeft, B Zur, C P Naehle
BACKGROUND: Prolonged breath holding results in hypoxemia and hypercapnia. Compensatory mechanisms help maintain adequate oxygen supply to hypoxia sensitive organs, but burden the cardiovascular system. The aim was to investigate human compensatory mechanisms and their effects on the cardiovascular system with regard to cardiac function and morphology, blood flow redistribution, serum biomarkers of the adrenergic system and myocardial injury markers following prolonged apnoea. METHODS: Seventeen elite apnoea divers performed maximal breath-hold during cardiovascular magnetic resonance imaging (CMR)...
June 18, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29909576/comparative-risks-of-bleeding-ischemic-stroke-and-mortality-with-direct-oral-anticoagulants-versus-phenprocoumon-in-patients-with-atrial-fibrillation
#14
Mariam Ujeyl, Ingrid Köster, Hans Wille, Thomas Stammschulte, Rebecca Hein, Sebastian Harder, Ursula Gundert-Remy, Julian Bleek, Peter Ihle, Helmut Schröder, Gerhard Schillinger, Anette Zawinell, Ingrid Schubert
PURPOSE: The pivotal trials for stroke prevention in non-valvular atrial fibrillation (NVAF) compared rivaroxaban, dabigatran, and apixaban with warfarin, as did most claims-based studies. Comparisons with phenprocoumon, the most frequently used vitamin K antagonist (VKA) in Germany, are scarce. METHODS: Risk of bleeding, ischemic stroke, and all-cause mortality in patients with NVAF were analyzed using data for 2010 to 2014 from a large German claims database. New users of oral anticoagulants from January 2012 to December 2013 were included and observed over 1 year...
June 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29908826/intramyocardial-autologous-cd34-cell-therapy-for-refractory-angina-a-meta-analysis-of-randomized-controlled-trials
#15
Poonam Velagapudi, Mohit Turagam, Dhaval Kolte, Sahil Khera, Omar Hyder, Paul Gordon, Herbert D Aronow, Jane Leopold, J Dawn Abbott
BACKGROUND: Previous studies have demonstrated that intramyocardial human CD34+ cells may relieve symptoms and improve clinical outcomes in chronic refractory angina unresponsive to optimal medical therapy or not amenable to revascularization. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of human CD34+ cells compared with placebo in chronic refractory angina. Primary efficacy outcomes in our analysis were angina frequency and exercise time...
June 5, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29908420/ticagrelor-versus-clopidogrel-after-fibrinolytic-therapy-in-patients-with-st-elevation-myocardial-infarction-rationale-and-design-of-the-ticagrelor-in-patients-with-st-elevation-myocardial-infarction-treated-with-thrombolysis-treat-trial
#16
Otavio Berwanger, Jose C Nicolau, Antonio C Carvalho, Lixin Jiang, Shaun Goodman, Stephen J Nicholls, Alexander Parkhomenko, Oleg Averkov, Carlos Tajer, Germán Malaga, Jose F Kerr Saraiva, Francisco Fonseca, Helio P Guimaraes, Pedro G M de Barros E Silva, Lucas P Damiani, Denise M Paisani, Camila M R Lasagno, Carolina T Candido, Nanci Valeis, Diogo D F Moia, Leopoldo S Piegas, Christopher B Granger, Harvey White, Renato D Lopes
BACKGROUND: The safety and efficacy of ticagrelor in patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remain uncertain. OBJECTIVES: The primary objective of the TicagRElor in pAtients with ST elevation myocardial infarction treated with Thrombolysis (TREAT) trial is to evaluate the short-term safety of ticagrelor when compared with clopidogrel in STEMI patients treated with fibrinolytic therapy. Key secondary objectives are to assess the safety and efficacy of ticagrelor compared with clopidogrel at 12-months...
March 3, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29907995/fifteen-years-of-life-losartan-intervention-for-endpoint-reduction-in-hypertension-lessons-learned-for-losartan-an-old-dog-playing-good-tricks
#17
REVIEW
Niki Katsiki, Konstantinos Tsioufis, Dilek Ural, Massimo Volpe
There is an unmet need to prevent cardiovascular disease and chronic kidney disease development and progression worldwide. Losartan, the first angiotensin receptor blocker, was shown to exert significant cardioprotective and renoprotective effects in the LIFE (Losartan Intervention for Endpoint Reduction in Hypertension) and RENAAL (Reduction of Endpoints in NIDDM With the Angiotensin II Antagonist Losartan) trials. Losartan significantly prevented stroke and decreased serum uric acid levels and the rates of new-onset diabetes mellitus and atrial fibrillation...
June 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29907947/introduction-of-direct-oral-anticoagulant-within-7-days-of-stroke-onset-a-nomogram-to-predict-the-probability-of-3-month-modified-rankin-scale-score-2
#18
Manuel Cappellari, Gianni Turcato, Stefano Forlivesi, Nicola Micheletti, Giampaolo Tomelleri, Bruno Bonetti, Giovanni Merlino, Roberto Eleopra, Monia Russo, Roberto L'Erario, Alessandro Adami, Carolina Gentile, Anna Gaudenzi, Sandro Bruno, Paolo Bovi
In clinical practice, direct oral anticoagulants (DOACs) are often started earlier (≤ 7 days) than in randomized clinical trials after stroke. We aimed to develop a nomogram model incorporating time of DOAC introduction ≤ 7 days of stroke onset in combination with different degrees of stroke radiological/neurological severity at the time of treatment to predict the probability of unfavorable outcome. We conducted a multicenter prospective study including 344 patients who started DOAC 1-7 days after atrial fibrillation-related stroke onset...
June 15, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29907575/current-evidence-for-anesthesia-management-during-endovascular-stroke-therapy-updated-systematic-review-and-meta-analysis
#19
Nitin Goyal, Konark Malhotra, Muhammad F Ishfaq, Georgios Tsivgoulis, Christopher Nickele, Daniel Hoit, Adam S Arthur, Andrei V Alexandrov, Lucas Elijovich
INTRODUCTION: Debate continues about the optimal anesthetic management for patients undergoing endovascular treatment (ET) of acute ischemic stroke due to emergent large vessel occlusion. OBJECTIVE: To compare, using current evidence, the clinical outcomes and procedural characteristics among patients undergoing general anesthesia (GA) and local or monitored anesthesia (non-GA). METHODS: We performed a systematic review and meta-analysis of all available studies that involved the use of stent retrievers for ET (stentriever group)...
June 15, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29906425/diastolic-hypotension-may-attenuate-benefits-from-intensive-systolic-targets-secondary-analysis-of-a-randomized-controlled-trial
#20
Todd C Lee, Rodrigo B Cavalcanti, Emily G McDonald, Louise Pilote, James M Brophy
BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT) was a randomized controlled trial which studied 9361 adults aged 50 and older with systolic blood pressure above 130mmHg and one or more cardiovascular risk factor. Patients were randomized to intensive (≤ 120mmHg) or standard (≤ 140mmHg) systolic targets. In August 2016, a limited dataset was released for secondary analysis. We hypothesized that excessive lowering of diastolic blood pressure could cause harm. Using the data from SPRINT, we sought to determine whether the development of diastolic hypotension during treatment was associated with adverse outcomes...
June 12, 2018: American Journal of Medicine
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