keyword
https://read.qxmd.com/read/38376536/hyperlipidaemia-in-diabetes-are-there-particular-considerations-for-next-generation-therapies
#21
REVIEW
Sophie Béliard, Florian Mourre, René Valéro
Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation therapies targeting circulating lipoparticle metabolism (LDL, VLDL, chylomicrons, HDL) have recently been approved by the European and US medical agencies, including anti- proprotein convertase subtilisin/kexin 9 (PCSK9) antibodies; an siRNA targeting PCSK9; bempedoic acid, which targets ATP citrate lyase; an antisense oligonucleotide targeting apolipoprotein C-III; an anti-angiopoietin-like 3 antibody; and a purified omega-3 fatty acid, icosapent ethyl...
February 20, 2024: Diabetologia
https://read.qxmd.com/read/38375465/the-significance-of-metabolic-disease-in-degenerative-cervical-myelopathy-a-systematic-review
#22
Celine Iswarya Partha Sarathi, Amil Sinha, Amir Rafati Fard, Faheem Bhatti, Tanzil Rujeedawa, Shahzaib Ahmed, Melika Akhbari, Aniqah Bhatti, Aria Nouri, Mark R Kotter, Benjamin M Davies, Oliver D Mowforth
INTRODUCTION: Degenerative cervical myelopathy (DCM) is a form of chronic spinal cord injury, with a natural history of potential for progression over time. Whilst driven by mechanical stress on the spinal cord from degenerative and congenital pathology, the neurological phenotype of DCM is likely to be modified by multiple systemic factors. The role of metabolic factors is therefore of interest, particularly given that ischaemia is considered a key pathological mechanism of spinal cord injury...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38374013/effect-of-solution-focused-approach-on-insight-and-phsychological-emotion-of-patients-with-nephrotic-syndrome-a-retrospective-study-from-the-hospital
#23
JOURNAL ARTICLE
Meng Liu, Xiufen Ge, Zhen Yan
OBJECTIVE: This study aims to explore the effect of the solution-focused approach on the insight and psychological emotion of patients with nephrotic syndrome (NS). METHODS: The clinical data of 185 Qingdao Municipal Hospital patients with NS from December 2020 to December 2022 were selected for retrospective analysis. According to different nursing modes, the patients were divided into the control group (CG, conventional nursing, n = 90) and the study group (SG, conventional nursing + solution-focused approach, n = 95)...
January 2024: Archivos Españoles de Urología
https://read.qxmd.com/read/38365303/cohort-profile-for-the-tongji-cardiovascular-health-study-a-prospective-multiomics-cohort-study
#24
JOURNAL ARTICLE
Ting Xu, Yueqi Lu, Bangwei Chen, Chenxin Deng, Yucong Zhang, Mei Wang, Huifen Ling, Yi Huang, Jing Yuan, Xin Jin, Lei Ruan, Tao Li, Cun-Tai Zhang
PURPOSE: The Tongji Cardiovascular Health Study aimed to further explore the onset and progression mechanisms of cardiovascular disease (CVD) through a combination of traditional cohort studies and multiomics analysis, including genomics, metabolomics and metagenomics. STUDY DESIGN AND PARTICIPANTS: This study included participants aged 20-70 years old from the Geriatric Health Management Centre of Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology...
February 15, 2024: BMJ Open
https://read.qxmd.com/read/38356731/efficacy-and-safety-of-stapokibart-cm310-in-uncontrolled-seasonal-allergic-rhinitis-merak-an-investigator-initiated-placebo-controlled-randomised-double-blind-phase-2-trial
#25
JOURNAL ARTICLE
Yuan Zhang, Bing Yan, Zehua Zhu, Xueyan Wang, Xicheng Song, Dongdong Zhu, Tingting Ma, Yu Zhang, Cuida Meng, Guangke Wang, Chengshuo Wang, Luo Zhang
BACKGROUND: There is no trial to assess the benefits of periodically using biologics during the pollen season in patients with uncontrolled seasonal allergic rhinitis (SAR), who have moderate-to-severe symptoms even after standard-of-care. This trial aimed to evaluate the efficacy and safety of the add-on administration of stapokibart, a humanised monoclonal antibody that targets interleukin-4 receptor alpha, in patients with uncontrolled SAR. METHODS: In this investigator-initiated, randomised, double-blind, placebo-controlled trial, eligible patients received either stapokibart 600-300 mg weekly (QW), every 2 weeks (Q2W), or placebo QW for 4 weeks...
March 2024: EClinicalMedicine
https://read.qxmd.com/read/38343287/prevalence-and-patterns-of-comorbidities-in-older-people-with-type-2-diabetes-in-australian-primary-care-settings
#26
JOURNAL ARTICLE
Wei Jin Wong, Tu Nguyen, Martin Fortin, Christopher Harrison
OBJECTIVE: The aim of this study was to identify the prevalence and patterns of comorbidity in community-dwelling older people with type 2 diabetes mellitus (T2DM) attending general practice settings in Australia. METHODS: This study involved a cross-sectional analysis using the Bettering the Evaluation and Care of Health (BEACH) sub-study data. In a series of sub-studies, a representative sample of general practitioners was asked to record all diagnosed chronic conditions for patients at 40 consecutive encounters using structured paper-based recording forms...
February 11, 2024: Australasian Journal on Ageing
https://read.qxmd.com/read/38342085/investigation-of-recessive-effects-of-coding-variants-on-common-clinical-phenotypes-in-exome-sequenced-uk-biobank-participants
#27
JOURNAL ARTICLE
David Curtis
Introduction Previous studies have demonstrated effects of rare coding variants on common, clinically relevant phenotypes although the additive burden of these variants makes only a small contribution to overall trait variance. Although recessive effects of individual homozygous variants have been studied, little work has been done to elucidate the impact of rare coding variants occurring together as compound heterozygotes. Methods In this study attempts were made to identify pairs of variants likely to be occurring as compound heterozygotes using 200,000 exome sequenced subjects from the UK Biobank...
February 10, 2024: Human Heredity
https://read.qxmd.com/read/38336454/use-of-drugs-for-hyperlipidaemia-and-diabetes-and-risk-of-primary-and-secondary-brain-tumours-nested-case-control-studies-using-the-uk-clinical-practice-research-datalink-cprd
#28
JOURNAL ARTICLE
Jamie W Robinson, Richard Martin, Mio Ozawa, Martha Maria Christine Elwenspoek, Maria Theresa Redaniel, Kathreena Kurian, Yoav Ben-Shlomo
OBJECTIVES: Previous studies have suggested that fibrates and glitazones may have a role in brain tumour prevention. We examined if there is support for these observations using primary care records from the UK Clinical Practice Research Datalink (CPRD). DESIGN: We conducted two nested case-control studies using primary and secondary brain tumours identified within CPRD between 2000 and 2016. We selected cases and controls among the population of individuals who had been treated with any anti-diabetic or anti-hyperlipidaemic medication to reduce confounding by indication...
February 9, 2024: BMJ Open
https://read.qxmd.com/read/38327030/an-updated-review-on-nelumbo-nucifera-gaertn-chemical-composition-nutritional-value-and-pharmacological-activities
#29
JOURNAL ARTICLE
Bhaskar Sahu, Mahendra Sahu, Mukesh Sahu, Megha Yadav
Nelumbo nucifera Gaertn is a recognised herbal plant in ancient medical sciences. Each portion of the plant leaf, flower, seed and rhizome is utilised for nutritional and medicinal purposes. The chemical compositions like phenol, alkaloids, glycoside, terpenoids and steroids have been isolated. The plant contains various nutritional values like lipids, proteins, amino acids, minerals, carbohydrates, and fatty acids. Traditional medicine confirms that the phytochemicals of plants give significant benefits to the treatment of various diseases such as leukoderma, smallpox, dysentery, haematemesis, coughing, haemorrhage, metrorrhagia, haematuria, fever, hyperlipidaemia, cholera, hepatopathy and hyperdipsia...
February 7, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38293377/-in-vivo-toxicity-anti-hyperlipidaemic-antioxidant-and-anti-atherogenic-activities-of-lipo-a-a-traditional-herbal-product-in-rodents
#30
JOURNAL ARTICLE
Solomon Appiah Kubi, Isaac Kingsley Amponsah, Bernard Kofi Turkson, Evelyn Asante-Kwatia, Desmond Nkrumah, Rita Akosua Dickson
Hyperlipidemia accounts for about 17 million deaths worldwide each year. High cost and side effects have limited the use of conventional anti-lipidaemic agents in some cases, majority of whom resort to traditional medicine. The current research focused on validating the safety and efficacy of a herbal product, 'LIPO A' used in the management of hyperlipidaemia. Induction of hyperlipidaemia was achieved by oral administration of 3 mL of cholesterol in coconut oil for 4 weeks in male Sprague Dawley rats with water available as 40 % sucrose...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38291949/identifying-high-cholesterol-in-the-ambulance-setting-a-mixed-methods-cohort-study-to-tackle-health-inequality
#31
JOURNAL ARTICLE
Karl Charlton, Jon Rees, Emma Burrow
BACKGROUND: Individuals with low socio-economic status (SES) have disproportionate rates of cardio- vascular disease (CVD) but poorer engagement with preventative health. This study aimed to compare characteristics of individuals with and without hyperlipidaemia and describe their health behaviours. METHODS: A mixed-methods study between January and December 2022. Patients aged ≥40 years using the ambulance service with blood pressure of ≥140/90 had their total cholesterol measured using a point of care device...
January 30, 2024: Journal of Public Health
https://read.qxmd.com/read/38282013/the-role-of-mitochondrial-dna-copy-number-in-cardiometabolic-disease-a-bidirectional-two-sample-mendelian-randomization-study
#32
REVIEW
Pei Qin, Tianhang Qin, Lei Liang, Xinying Li, Bin Jiang, Xiaojie Wang, Jianping Ma, Fulan Hu, Ming Zhang, Dongsheng Hu
BACKGROUND: This study used a bidirectional 2-sample Mendelian randomization study to investigate the potential causal links between mtDNA copy number and cardiometabolic disease (obesity, hypertension, hyperlipidaemia, type 2 diabetes [T2DM], coronary artery disease [CAD], stroke, ischemic stroke, and heart failure). METHODS: Genetic associations with mtDNA copy number were obtained from a genome-wide association study (GWAS) summary statistics from the UK biobank (n = 395,718) and cardio-metabolic disease were from largest available GWAS summary statistics...
January 28, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38279888/characteristics-and-management-of-generalized-pustular-psoriasis-gpp-experience-from-the-central-and-eastern-europe-cee-gpp-expert-network
#33
JOURNAL ARTICLE
P Wolf, R Ceovic, C Conrad, K Falkensteiner, T Graier, M Kołt-Kamińska, M Marovt, V Mateeva, J-T Maul, A A Navarini, A C Nicolescu, G Ratzinger, L Pavlovsky, M Sanzharovskaya, A Szegedi, A Reich
BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by widespread eruption of sterile pustules with or without systemic symptoms. OBJECTIVES: This study aimed to describe the demographics of patients with GPP in Central and Eastern Europe (CEE), present the clinical characteristics of individual GPP flares and explore the current treatment landscape. METHODS: Patient demographics were collected at the times of last observation and previous treatment...
January 27, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38263837/morning-blood-pressure-surge-and-intracranial-atherosclerotic-plaque-characteristics-a-high-resolution-magnetic-resonance-vessel-wall-imaging-study
#34
JOURNAL ARTICLE
Yuhan Jiang, Xiaowei Song, Duoduo Hou, Xihai Zhao, Wenwen Chen, Rui Li, Zhuozhao Zheng, Zhenhua Sang, Jian Wu
OBJECTIVE: To investigate the relationship between morning blood pressure surge (MBPS) and intracranial atherosclerotic plaque burden and vulnerability. METHODS: A total of 267 ischaemic stroke patients were retrospectively analysed. Sleep-trough and prewaking MBPS were calculated from ambulatory blood pressure monitoring (ABPM). Plaque characteristics, including intraplaque haemorrhage (IPH), maximum wall thickness (max WT), and stenosis degree, were obtained from high-resolution MR vessel wall imaging (HR-vwMRI)...
January 23, 2024: British Journal of Radiology
https://read.qxmd.com/read/38243357/an-altered-plasma-lipidome-phenome-network-characterizes-heart-failure-with-preserved-ejection-fraction
#35
JOURNAL ARTICLE
Nina Jovanovic, Anna Foryst-Ludwig, Christian Klose, Cristina Rozados da Conceicao, Lina Alasfar, Till Birkner, Sofia K Forslund, Ulrich Kintscher, Frank Edelmann
AIMS: Heart failure with preserved ejection fraction (HFpEF) is a multifactorial, multisystemic syndrome that involves alterations in lipid metabolism. This study aimed to test whether distinct plasma lipid profiles or lipid entities or both are associated with clinical and functional echocardiographic parameters in HFpEF. METHODS AND RESULTS: We examined the human plasma lipidome in HFpEF patients (n = 18) with left ventricular ejection fraction ≥50% and N-terminal pro-brain natriuretic peptide (NT-proBNP) >125 pg/mL and control subjects (n = 12) using mass spectrometry-based shotgun lipidomics...
January 19, 2024: ESC Heart Failure
https://read.qxmd.com/read/38242553/increased-prevalence-of-hearing-loss-tinnitus-and-sudden-deafness-among-patients-with-sj%C3%A3-gren-s-syndrome
#36
JOURNAL ARTICLE
Tzong-Hann Yang, Sudha Xirasagar, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
BACKGROUND: This study aimed to provide an updated prevalence of hearing loss, tinnitus, vertigo and sudden deafness on patients with Sjögren's syndrome and matched comparison patients. METHODS: Data for this study were retrieved from the Taiwan Longitudinal Health Insurance Database and Taiwan's registered catastrophic illness dataset. This study included 20 266 patients with Sjögren's syndrome as the study group and 60 798 propensity score-matched comparison patients as the comparison group...
January 19, 2024: RMD Open
https://read.qxmd.com/read/38242225/hegemony-of-inflammation-in-atherosclerosis-and-coronary-artery-disease
#37
REVIEW
Ali Attiq, Sheryar Afzal, Waqas Ahmad, Mahmoud Kandeel
Inflammation drives coronary artery disease and atherosclerosis implications. Lipoprotein entry, retention, and oxidative modification cause endothelial damage, triggering innate and adaptive immune responses. Recruited immune cells orchestrate the early atherosclerotic lesions by releasing proinflammatory cytokines, expediting the foam cell formation, intraplaque haemorrhage, secretion of matrix-degrading enzymes, and lesion progression, eventually promoting coronary artery syndrome via various inflammatory cascades...
March 5, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38239713/involvement-of-single-nucleotide-polymorphisms-of-junction-adhesion-molecule-with-small-vessel-vascular-dementia
#38
JOURNAL ARTICLE
Peter Xie, Kiran Kancherla, Sashiruben Chandramohan, Nady Braidy, Eunice Kar Wing Chan, Ying Hua Xu, Daniel K Y Chan
OBJECTIVES: It is now recognized that blood brain barrier (BBB) leakage occurs in cerebral small vascular disease (CSVD) and plays a significant role in the pathophysiology of vascular dementia. We hypothesized that genetic polymorphisms of junctional adhesion molecule-A (JAM-A) (which may result in compromised structure of tight junction proteins that form the BBB) in combination with cerebrovascular risk factors hypertension, lipid disorders, and type 2 diabetes may result in BBB leakage and increase the individual's risk of CSVD-related dementia...
December 2023: Aging medicine
https://read.qxmd.com/read/38231319/ethnic-disparities-and-covid-19-pneumonia-in-ireland-a-single-centre-descriptive-study-of-hospitalised-patients-in-a-tertiary-university-teaching-hospital
#39
JOURNAL ARTICLE
Rhea O'Regan, Finbarr Harnedy, Bearach Reynolds, Liam Cormican
In this study, we aim to describe the demographic, clinical and imaging characteristics, treatment course and subsequent outcomes of the first 116 cases presenting to a tertiary Dublin hospital with COVID-19 infection and to compare whether ethnic minority background was a risk factor for poorer disease outcomes in this cohort. Of 116 cases analysed, 100 (86%) patients presented from the community, 6 (5%) from care homes and 10 (9%) were existing inpatients. Fifty-four (46%) patients identified as being from an ethnic minority group...
January 17, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38184198/diet-overall-and-hypocaloric-diets-are-associated-with-improvements-in-depression-but-not-anxiety-in-people-with-metabolic-conditions-a-systematic-review-and-meta-analysis
#40
REVIEW
Tonya Paris, Robin M Daly, Gavin Abbott, Surhbi Sood, Christine L Freer, Marno C Ryan, Elena S George
The risk of depression and anxiety are higher in people with metabolic conditions, but whether dietary approaches which are central to the management of metabolic conditions, can also improve depression and anxiety is uncertain. The primary aim of this systematic review and meta-analysis was to evaluate the effects of dietary interventions on depression and anxiety in adults with metabolic conditions. The secondary aims were to evaluate the effects of hypocaloric and isocaloric dietary interventions on these outcomes...
January 4, 2024: Advances in Nutrition
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