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Hyperlipidaemia

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https://www.readbyqxmd.com/read/28064554/evaluating-bempedoic-acid-for-the-treatment-of-hyperlipidaemia
#1
Peter Penson, Mary McGowan, Maciej Banach
Despite the effectiveness of statins in the treatment of lipid disorders, residual risk still exists, and hitherto studies where additional drugs were added to statin therapy have been mainly negative or the outcomes were very modest. Therefore there is still a need for new and effective oral agents in the combination therapy of lipid disorders. Areas Covered: The review covers the current state of knowledge on the mechanism of action of bempedoic acid (ETC-1002) and results from recent clinical studies. Expert Opinion: ETC-1002 is a novel oral lipid-lowering therapy...
January 9, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28062468/comparison-of-self-perceived-cardiovascular-disease-risk-among-smokers-with-framingham-and-procam-scores-a-cross-sectional-analysis-of-baseline-data-from-a-randomised-controlled-trial
#2
Benoît Desgraz, Tinh-Hai Collet, Nicolas Rodondi, Jacques Cornuz, Carole Clair
OBJECTIVES: Previous studies suggest that smokers have a misperception of their 10-year cardiovascular risk. We aimed to compare 10-year cardiovascular risk self-perception and calculated risk among smokers willing to quit and assess the determinants of a possible misperception. DESIGN: Cross-sectional secondary analysis of baseline data from a randomised controlled trial of smoking cessation. PARTICIPANTS: 514 participants, mean age 51.1 years, 46% women, 98% Caucasian...
January 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28045971/anti-diabetic-effects-of-jiang-tang-xiao-ke-granule-via-pi3k-akt-signalling-pathway-in-type-2-diabetes-kkay-mice
#3
Na Yu, Xin Fang, Dandan Zhao, Qianqian Mu, Jiacheng Zuo, Yue Ma, Yi Zhang, Fangfang Mo, Dongwei Zhang, Guangjian Jiang, Rui Wu, Sihua Gao
Jiang Tang Xiao Ke (JTXK) granule, a Chinese herbal formula, has been used clinically to treat type 2 diabetes (T2DM) for decades. Our previous studies showed that JTXK granule exhibited anti-diabetic and anti-oxidative functions in experimental diabetic rats induced by a high fat diet and streptozotocin. However, the underlying mechanisms remain poorly understood. Herein, we aimed to investigate the therapeutic effect of JTXK granule on T2DM KKAy mice and the possible associations with skeletal muscle in the current study...
2017: PloS One
https://www.readbyqxmd.com/read/28030918/to-treat-or-not-to-treat-drug-refractory-epilepsy-by-the-ketogenic-diet-that-is-the-question
#4
REVIEW
Marzena Ułamek-Kozioł, Ryszard Pluta, Anna Bogucka-Kocka, Stanisław J Czuczwar
Epilepsy is a serious neurologic disorder worldwide which affects about 1% of the population (ca. 50 million people), the highest prevalence occurring in both children and elderly. Apart from idiopathic forms, etiology of the disease involves multiple brain risk factors - the most frequent being cerebrovascular diseases, tumours and traumatic injuries. Several treatment options exist, including, for instance, pharmacotherapy, vagal nerve stimulation or epilepsy surgery. In spite of treatment, about 30% of patients with epilepsy still have seizures and become drug-refractory...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28012169/curcumin-as-a-potential-candidate-for-treating-hyperlipidemia-a-review-of-cellular-and-metabolic-mechanisms
#5
REVIEW
Yunes Panahi, Yasin Ahmadi, Manouchehr Teymouri, Thomas P Johnston, Amirhossein Sahebkar
Curcumin is an herbal polyphenol extensively investigated for antioxidant, anti-inflammatory and hypolipidaemic properties. In the present review, the efficacy of curcumin for improving a plasma lipid profile has been evaluated and compared with statins, a well-known class of medicines for treating hypercholesterolemia and hyperlipidaemia. Curcumin is presumably most effective in reducing triglyceride (TG), while statins are most efficient in lowering low-density lipoproteins-cholesterol (LDL-C). Additionally, various molecular and metabolic mediators of cholesterol and plasma lipid homeostasis are discussed in relation to how they are modulated by curcumin or statins...
December 24, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28004036/the-microbial-hypothesis-contributions-of-adenovirus-infection-and-metabolic-endotoxaemia-to-the-pathogenesis-of-obesity
#6
REVIEW
Amos Tambo, Mohsin H K Roshan, Nikolai P Pace
The global obesity epidemic, dubbed "globesity" by the World Health Organisation, is a pressing public health issue. The aetiology of obesity is multifactorial incorporating both genetic and environmental factors. Recently, epidemiological studies have observed an association between microbes and obesity. Obesity-promoting microbiome and resultant gut barrier disintegration have been implicated as key factors facilitating metabolic endotoxaemia. This is an influx of bacterial endotoxins into the systemic circulation, believed to underpin obesity pathogenesis...
2016: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/27995261/interval-increase-in-the-prevalence-of-symptomatic-cholelithiasis-associated-non-alcoholic-fatty-liver-disease-over-a-ten-year-period-in-an-asian-population
#7
Kevin Beng Chin Khaw, Rachel Huiyi Choi, Juinn Huar Kam, Bibhas Chakraborty, Pierce Kah Hoe Chow
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is frequently associated with cholelithiasis. The prevalence of NAFLD has been on the rise in Asia, but the magnitude of this increase has not been previously studied. METHODS: A retrospective cohort study was carried out on consecutive patients who underwent laparoscopic or open cholecystectomy from November 2001 to November 2004 (cohort 1) and from November 2011 to November 2014 (cohort 2) at Singapore General Hospital...
December 20, 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27990115/urgent-coronary-artery-bypass-surgery-in-a-patient-with-postinfarction-angina-and-active-myelomonocytic-leukaemia
#8
Samuel Anthony Galea, Joseph Galea
Chronic myelomonocytic leukaemia (CMML) is a myelodysplastic/myeloproliferative neoplasm affecting the production and differentiation of the monocyte cell lineage. Cardiac surgery in the context of CMML poses challenges that are not routinely encountered. This is the first reported case in the literature of a patient with active CMML undergoing urgent on-pump coronary artery bypass grafting. A 68-year-old Caucasian man with a history of hypertension, hyperlipidaemia, hypothyroidism, and hypercholesterolaemia, who had been diagnosed by the haematologists with CMML a few months earlier but had remained untreated, underwent urgent surgical coronary revascularisation because of postinfarction angina following a non-ST elevation myocardial infarction associated with troponin I rise...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27974372/non-communicable-diseases-in-decontamination-workers-in-areas-affected-by-the-fukushima-nuclear-disaster-a-retrospective-observational-study
#9
Toyoaki Sawano, Masaharu Tsubokura, Akihiko Ozaki, Claire Leppold, Shuhei Nomura, Yuki Shimada, Sae Ochi, Manabu Tsukada, Tsuyoshi Nemoto, Shigeaki Kato, Yukio Kanazawa, Hiromichi Ohira
OBJECTIVES: To assess the prevalence of non-communicable diseases (NCDs), and whether NCDs were treated or not, among hospitalised decontamination workers who moved to radio-contaminated areas after Japan's 2011 Fukushima Daiichi Nuclear Power Plant disaster. METHODS: We retrospectively extracted records of decontamination workers admitted to Minamisoma Municipal General Hospital between 1 June 2012 and 31 August 2015, from hospital records. We investigated the incidence of underlying NCDs such as hypertension, dyslipidaemia and diabetes among the decontamination workers, and their treatment status, in addition to the reasons for their hospital admission...
December 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/27924965/the-effect-of-ezetimibe-monotheraphy-on-mean-platelet-volume-in-patients-with-hyperlipidaemia-a-retrospective-study-of-45-patients
#10
Yasar Sertbas, Meltem Sertbas, Ugur Ersoy, Bulent Bilir, Seracettin Gunaydin, Ali Ozdemir
OBJECTIVE: To investigate the effect of ezetimibe on platelet functions as a drug which increases mevalonate levels. METHODS: This retrospective study was conducted in Istanbul, Turkey, and comprised record of normolipidaemic and hyperlipidaemic patients taken from the outpatient clinic from October 2004 to February 2015,. The results were taken from the baseline and third-month data of ezetimibe treatment. SPSS 22 was used for statistical analysis. RESULTS: Of the total, there were 50(53%) normolipidaemic patients and 45(47%) hyperlipidaemic ones...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27896880/a-community-based-cross-sectional-survey-of-medication-utilization-among-chronic-disease-patients-in-china
#11
Mark A Strand, Kirstin Gramith, Macy Royston, Xiaoxi Wang, Judith Perry, Curt Elliott
OBJECTIVES: To determine medication use patterns and associated health outcomes in Chinese individuals with diabetes, hypertension or hyperlipidaemia. METHODS: This community-based cross-sectional study was done in a north China city of 300 000 people. Participants were recruited by poster and phone call through Community Health Centres. Data were collected on 638 Chinese individuals. Interviews were done to screen for disease and health behaviours. Fasting blood was collected and analyzed...
November 29, 2016: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27888640/chronotherapy-versus-conventional-statins-therapy-for-the-treatment-of-hyperlipidaemia
#12
REVIEW
Jose Manuel Izquierdo-Palomares, Jesus Maria Fernandez-Tabera, Maria N Plana, Almudena Añino Alba, Pablo Gómez Álvarez, Inmaculada Fernandez-Esteban, Luis Carlos Saiz, Pilar Martin-Carrillo, Óscar Pinar López
BACKGROUND: Elevated levels of total cholesterol and low-density lipoprotein play an important role in the development of atheromas and, therefore, in cardiovascular diseases. Cholesterol biosynthesis follows a circadian rhythm and is principally produced at night (between 12:00 am and 6:00 am). The adjustment of hypolipaemic therapy to biologic rhythms is known as chronotherapy. Chronotherapy is based on the idea that medication can have different effects depending on the hour at which it is taken...
26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27852582/association-between-oct-based-microangiography-perfusion-indices-and-diabetic-retinopathy-severity
#13
Alexander D Lin, Aaron Y Lee, Qinqin Zhang, Kasra A Rezaei, James Kinyoun, Ruikang K Wang, Cecilia S Lee
AIM: To evaluate the association between retinal capillary non-perfusion and diabetic retinopathy (DR) severity using optical coherence tomography-based microangiography (OMAG). METHODS: 33 patients (51 eyes) with a history of diabetes underwent imaging with a 68 kHz Cirrus-5000 spectral domain OMAG prototype. Demographic and clinical characteristics were collected. The perfusion index (PI) was defined as per cent coverage of area by retinal vessels with flow, measured within a minimum of 6...
November 15, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27836869/hospital-diagnosed-atopic-dermatitis-and-long-term-risk-of-myocardial-infarction-a-population-based-follow-up-study
#14
Jette Lindorff Riis, Christian Vestergaard, Kasper Fjellhaugen Hjuler, Lars Iversen, Lars Jakobsen, Mette S Deleuran, Morten Olsen
OBJECTIVE: Atopic dermatitis (AD) is an inflammatory skin disorder with a childhood prevalence reaching 20%. An estimated 50% of patients have a life-long chronic course. The purpose of this study was to estimate the risk of first-time myocardial infarction (MI) in patients with AD compared with a general population cohort. DESIGN: Cohort study. SETTING: Denmark. PARTICIPANTS: Using population-based medical registries, we identified individuals born in Denmark from 1947 to 1983 with at least two hospital-diagnoses of AD following inpatient admissions or hospital-based outpatient visits at any age from 1977 to 2013...
November 11, 2016: BMJ Open
https://www.readbyqxmd.com/read/27834493/an-emerging-trend-in-functional-foods-for-the-prevention-of-cardiovascular-disease-and-diabetes-marine-algal-polyphenols
#15
Margaret Murray, Aimee L Dordevic, Lisa Ryan, Maxine P Bonham
Marine macroalgae are gaining recognition among the scientific community as a significant source of functional food ingredients. Due to the harsh environments in which macroalgae survive, they produce unique bioactive compounds that are not found in terrestrial plants. Polyphenols are the predominant bioactive compound in brown algae and are accountable for the majority of its biological activity. Phlorotannins are a type of polyphenol that are unique to marine sources and have exhibited protective effects against hyperglycaemia, hyperlipidaemia, inflammation and oxidative stress, known risk factors for cardiovascular disease and diabetic complications, in cell culture, animal studies and some human studies...
November 11, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27832581/effect-of-nutritionally-induced-hyperlipidaemia-on-in-vitro-bovine-embryo-quality-depends-on-the-type-of-major-fatty-acid-in-the-diet
#16
Waleed F A Marei, Maria Arias Alvarez, Veerle Van Hoeck, Alfonso Gutierrez-Adan, Peter E J Bols, Jo L M R Leroy
The present study examined whether the effects of dietary-induced hyperlipidaemia on preimplantation embryo development depend on the predominant fatty acid (FA) type in the diet. In a combined in vivo-in vitro bovine model, two groups of cows (n=3 in each group) were fed with three diets consecutively (4 weeks feeding for each): (1) a maintenance control diet (CONT); (2) a high-starch diet rich in saturated fat (SAT); and (3) a high-starch diet rich in omega-3 unsaturated fat (UNSAT). Two feeding sequences were used to test for carry-over effects: Group A was fed CONT, SAT1 and then UNSAT2, whereas Group B was fed CONT, UNSAT1 and then SAT2...
November 11, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27826011/roles-of-the-nlrp3-inflammasome-in-the-pathogenesis-of-diabetic-nephropathy
#17
REVIEW
Yuan-Ye Qiu, Li-Qin Tang
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and persistent inflammation in circulatory and renal tissues is an important pathophysiological basis for DN. The essence of the microinflammatory state is the innate immune response, which is central to the occurrence and development of DN. Members of the inflammasome family, including both "receptors" and "regulators", are key to the inflammatory immune response. Nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) and other inflammasome components are able to detect endogenous danger signals, resulting in activation of caspase-1 as well as interleukin (IL)-1β, IL-18 and other cytokines; these events stimulate the inflammatory cascade reaction, which is crucial for DN...
December 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27805973/hyperlipidaemia-in-immunosuppression
#18
Maaike Kockx, Leonard Kritharides
No abstract text is available yet for this article.
December 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27803548/non-st-elevation-myocardial-infarction-and-coronary-artery-stenting-in-pregnancy-in-a-woman-with-resistant-familial-hyperlipidaemia
#19
Anna Liza Roslani, Abdul Hadi Jaafar, Anwar Irawan Ruhani
No abstract text is available yet for this article.
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27798670/prospective-multicentre-nationwide-clinical-data-from-600-cases-of-acute-pancreatitis
#20
Andrea Párniczky, Balázs Kui, Andrea Szentesi, Anita Balázs, Ákos Szűcs, Dóra Mosztbacher, József Czimmer, Patrícia Sarlós, Judit Bajor, Szilárd Gódi, Áron Vincze, Anita Illés, Imre Szabó, Gabriella Pár, Tamás Takács, László Czakó, Zoltán Szepes, Zoltán Rakonczay, Ferenc Izbéki, Judit Gervain, Adrienn Halász, János Novák, Stefan Crai, István Hritz, Csaba Góg, János Sümegi, Petra Golovics, Márta Varga, Barnabás Bod, József Hamvas, Mónika Varga-Müller, Zsuzsanna Papp, Miklós Sahin-Tóth, Péter Hegyi
OBJECTIVE: The aim of this study was to analyse the clinical characteristics of acute pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the major recommendations in the IAP/APA evidence-based guidelines for the management of AP. DESIGN: Eighty-six different clinical parameters were collected using an electronic clinical research form designed by the Hungarian Pancreatic Study Group. PATIENTS: 600 adult patients diagnosed with AP were prospectively enrolled from 17 Hungarian centres over a two-year period from 1 January 2013...
2016: PloS One
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