C R Yang, X Y Zhang, Y Liu, J Y Du, R Liang, M Yu, F Q Zhang, X F Mu, F Li, L Zhou, F H Zhou, F J Meng, S Wang, D Ming, X F Zhou
Depression is a worldwide problem with a great social and economic burden in many countries. In our previous research, we found that the expression of proBDNF/p75NTR/sortilin is upregulated in patients with major depressive disorder. In addition, the treatment of proBDNF antibodies reversed both the depressive behaviors and the reduced BDNF mRNA detected in our rodent chronic stress models. Antidepressant drugs are usually only effective in a subpopulation of patients with major depression with a delayed time window of 2-4 weeks to exert their efficacy...
January 2020: Neurotoxicity Research