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https://www.readbyqxmd.com/read/29171676/tween-television-and-peers-reinforcing-social-agents-in-early-adolescents-body-surveillance-and-self-objectification
#1
Ann Rousseau, Steven Eggermont
Sociocultural models of body image posit that the media and peers play a role in early adolescents' body dissatisfaction. Introducing a sociocultural perspective on youth sexualization, the present three-wave panel study (N = 968, Mage  = 11.30) sought to examine the role of tween television and peer appearance conversations in early adolescents' body surveillance and self-objectification over time. Special attention was given to the mediating role of media internalization in these relationships. The results showed evidence for a reciprocal interaction between media internalization and peer appearance conversations and identified this reciprocal interaction as the underlying mechanism linking tween television exposure to higher levels of body surveillance and self-objectification 1 year later...
November 24, 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29152869/linking-magazine-exposure-to-social-appearance-anxiety-the-role-of-appearance-norms-in-early-adolescence
#2
Jolien Trekels, Steven Eggermont
Early adolescents (N = 1,591; Mage  = 11.698; SD = 0.892) participated in a two-wave panel study (6-month interval) to examine the longitudinal association between appearance-focused magazine exposure and social appearance anxiety. We revealed that magazine exposure positively correlated with the internalization of appearance ideals and the attribution of social rewards to attractiveness which, in turn, related to social appearance anxiety. Internalization and attribution of social rewards formed a reinforcing spiral; once internalized, early adolescents associate positive things with appearance ideals (e...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29100546/the-need-for-a-network-to-establish-and-validate-predictive-biomarkers-in-cancer-immunotherapy
#3
EDITORIAL
Giuseppe V Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A Fox, Ena Wang, Francesco M Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H Butterfield, Lisa Villabona, Magdalena Thurin, Michael A Postow, Paul M Sondel, Sandra Demaria, Sanjiv Agarwala, Paolo A Ascierto
Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, the entire medical oncology field has been revolutionized by the introduction of immune checkpoints inhibitors. Despite success in a variety of malignancies, responses typically only occur in a small percentage of patients for any given histology or treatment regimen. There are also concerns that immunotherapies are associated with immune-related toxicity as well as high costs. As such, identifying biomarkers to determine which patients are likely to derive clinical benefit from which immunotherapy and/or be susceptible to adverse side effects is a compelling clinical and social need...
November 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29097494/gut-microbiome-influences-efficacy-of-pd-1-based-immunotherapy-against-epithelial-tumors
#4
Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P M Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein, Kristina Iribarren, Laura Mondragón, Nicolas Jacquelot, Bo Qu, Gladys Ferrere, Céline Clémenson, Laura Mezquita, Jordi Remon Masip, Charles Naltet, Solenn Brosseau, Coureche Kaderbhai, Corentin Richard, Hira Rizvi, Florence Levenez, Nathalie Galleron, Benoit Quinquis, Nicolas Pons, Bernhard Ryffel, Véronique Minard-Colin, Patrick Gonin, Jean-Charles Soria, Eric Deutsch, Yohann Loriot, François Ghiringhelli, Gérard Zalcman, François Goldwasser, Bernard Escudier, Matthew D Hellmann, Alexander Eggermont, Didier Raoult, Laurence Albiges, Guido Kroemer, Laurence Zitvogel
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizeable minority of cancer patients. Here, we show that primary resistance to ICI can be due to abnormal gut microbiome composition. Antibiotics (ATB) inhibited the clinical benefit of ICI in patients with advanced cancer. Fecal microbiota transplantation (FMT) from cancer patients who responded to ICI (but not from non-responding patients) into germ-free or ATB-treated mice ameliorated the antitumor effects of PD-1 blockade...
November 2, 2017: Science
https://www.readbyqxmd.com/read/29095202/simultaneous-inhibition-of-tumor-necrosis-factor-receptor-1-and-matrix-metalloproteinase-8-completely-protects-against-acute-inflammation-and-sepsis
#5
Sophie Steeland, Sara Van Ryckeghem, Jolien Vandewalle, Marlies Ballegeer, Elien Van Wonterghem, Melanie Eggermont, Johan Decruyenaere, Liesbet De Bus, Claude Libert, Roosmarijn E Vandenbroucke
OBJECTIVES: Sepsis causes very high mortality and morbidity rates and remains one of the biggest medical challenges. This study investigates whether plasma levels of both matrix metalloproteinase 8 and tumor necrosis factor receptor 1 are associated with sepsis severity and also investigates the therapeutic applicability of simultaneous inhibition of the two molecules in sepsis. DESIGN: Observational human pilot study-prospective controlled animal study. SETTING: University hospital and research laboratory...
October 31, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29095056/-i-can-should-look-like-a-media-figure-the-association-between-direct-and-indirect-media-exposure-and-teens-sexualizing-appearance-behaviors
#6
Jolien Trekels, Steven Eggermont
Prior research has examined the influence of media exposure on adolescents' sexualized self-concept, but engagement in sexualizing appearance behaviors remains understudied, especially among a younger age group (i.e., early adolescents). This three-wave panel study among 971 nine- to 14-year-olds (Mage = 12.99, SD = 1.03) showed that discussing media content with friends (i.e., indirect media exposure) was indirectly related to sexualizing appearance behaviors through perceived attainability of the appearance ideal...
November 2, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29039700/browsing-posting-and-liking-on-instagram-the-reciprocal-relationships-between-different-types-of-instagram-use-and-adolescents-depressed-mood
#7
Eline Frison, Steven Eggermont
Although studies have shown that Instagram use and young adults' mental health are cross-sectionally associated, longitudinal evidence is lacking. In addition, no study thus far examined this association, or the reverse, among adolescents. To address these gaps, we set up a longitudinal panel study among 12- to 19-year-old Flemish adolescents to investigate the reciprocal relationships between different types of Instagram use and depressed mood. Self-report data from 671 adolescent Instagram users (61% girls; MAge = 14...
October 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29028110/melanoma-staging-evidence-based-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#8
Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson
Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria...
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28968566/the-2017-complete-overhaul-of-adjuvant-therapies-for-high-risk-melanoma-and-its-consequences-for-staging-and-management-of-melanoma-patients
#9
Alexander M M Eggermont, Reinhard Dummer
The spectacular outcomes of the phase III trials regarding nivolumab versus ipilimumab in fully resected stage IIIB/C-IV and of the combination of dabrafenib (D) plus trametinib (T) in BRAF-mutant stage III patients demonstrate that effective treatments in advanced melanoma are also highly effective in the adjuvant setting. In 2016, an overall survival benefit with adjuvant high-dose ipilimumab was demonstrated, and the European Organisation for Research and Treatment of Cancer trial 1325 comparing pembrolizumab versus placebo will complete the picture in the early 2018...
September 28, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28941782/level-of-parenting-stress-in-mothers-of-singletons-and-mothers-of-twins-until-one-year-postpartum-a-cross-sectional-study
#10
Marjon De Roose, Dimitri Beeckman, Katrijn Eggermont, Elke Vanhouche, Ann Van Hecke, Sofie Verhaeghe
PROBLEM: To date, it is unclear which factors are associated with parenting stress. BACKGROUND: There are no studies investigating the association between parenting stress and coping strategies such as coparenting and social support, while simultaneously considering demographic and obstetric factors, in mothers of singletons and twins. AIM: To investigate if parenting stress is associated with personal, and obstetric characteristics, the level of coparenting, and the availability of and satisfaction with social support in mothers of singletons and twins until one year postpartum...
September 20, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28928380/predictors-of-responses-to-immune-checkpoint-blockade-in-advanced-melanoma
#11
N Jacquelot, M P Roberti, D P Enot, S Rusakiewicz, N Ternès, S Jegou, D M Woods, A L Sodré, M Hansen, Y Meirow, M Sade-Feldman, A Burra, S S Kwek, C Flament, M Messaoudene, C P M Duong, L Chen, B S Kwon, A C Anderson, V K Kuchroo, B Weide, F Aubin, C Borg, S Dalle, O Beatrix, M Ayyoub, B Balme, G Tomasic, A M Di Giacomo, M Maio, D Schadendorf, I Melero, B Dréno, A Khammari, R Dummer, M Levesque, Y Koguchi, L Fong, M Lotem, M Baniyash, H Schmidt, I M Svane, G Kroemer, A Marabelle, S Michiels, A Cavalcanti, M J Smyth, J S Weber, A M Eggermont, L Zitvogel
Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-based approach to an assessment of 779 paired blood and tumor markers in 37 stage III MMel patients, we analyzed association between blood immune parameters and the functional immune reactivity of tumor-infiltrating cells after ex vivo exposure to ICB...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28922786/relapse-free-survival-as-a-surrogate-for-overall-survival-in-the-evaluation-of-stage-ii-iii-melanoma-adjuvant-therapy
#12
REVIEW
Stefan Suciu, Alexander M M Eggermont, Paul Lorigan, John M Kirkwood, Svetomir N Markovic, Claus Garbe, David Cameron, Srividya Kotapati, Tai-Tsang Chen, Keith Wheatley, Natalie Ives, Gaetan de Schaetzen, Achmad Efendi, Marc Buyse
Background: We assessed whether relapse-free survival (RFS; time until recurrence/death) is a valid surrogate for overall survival (OS) among resected stage II-III melanoma patients through a meta-analysis of randomized controlled trials. Methods: Individual patient data (IPD) on RFS and OS were collected from 5826 patients enrolled in 11 randomized adjuvant trials comparing interferon (IFN) to observation. In addition, IPD from two studies comparing IFN and vaccination in 989 patients were included...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28901053/tissue-characterization-with-depth-resolved-attenuation-coefficient-and-backscatter-term-in-intravascular-optical-coherence-tomography-images
#13
Shengnan Liu, Yohei Sotomi, Jeroen Eggermont, Gaku Nakazawa, Sho Torii, Takeshi Ijichi, Yoshinobu Onuma, Patrick W Serruys, Boudewijn P F Lelieveldt, Jouke Dijkstra
An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different atherosclerotic tissue types with a robust implementation of depth-resolved (DR) approach. Therefore, the DR model is introduced to estimate the attenuation coefficient and further extended to estimate the backscatter-related term in IVOCT images, such that values can be estimated per pixel without predefining any delineation for the estimation...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28846388/affinity-based-purification-of-polyisocyanopeptide-bioconjugates
#14
Roel Hammink, Loek J Eggermont, Themistoklis Zisis, Jurjen Tel, Carl G Figdor, Alan E Rowan, Kerstin G Blank
Water-soluble polyisocyanopeptides (PICs) are a new class of synthetic polymers that mimic natural protein-based filaments. Their unique semiflexible properties combined with a length of several hundred nanometers have recently enabled a number of biomedical applications ranging from tissue engineering to cancer immunotherapy. One crucial step toward the further development of PICs for these applications is the efficient and controlled synthesis and purification of PIC-biomolecule conjugates. Considering the large size of PICs and the biomolecules to be conjugated, conjugation reactions do usually not proceed to completion due to steric effects...
October 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28750266/the-role-of-appearance-schematicity-in-the-internalization-of-media-appearance-ideals-a-panel-study-of-preadolescents
#15
Ann Rousseau, Hilary Gamble, Steven Eggermont
Individuals who are more strongly invested in their appearance, appearance schematics, have a tendency to engage in appearance-related comparison. Appearance schematicity consists of two components. The self-evaluative component concerns the degree to which appearance is central to self-worth, referred to as dysfunctional appearance beliefs. Motivational salience refers to the engagement in behaviors designed to enhance appearance, such as body surveillance. Based on a three-wave panel survey of 973 Flemish preadolescents (Mage = 11...
October 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28740915/limited-short-term-effect-of-palliative-radiation-therapy-on-quantitative-computed-tomography-derived-bone-mineral-density-in-femora-with-metastases
#16
Florieke Eggermont, Loes C Derikx, Nico Verdonschot, Gerjon Hannink, Robert S J P Kaatee, Esther Tanck, Yvette M van der Linden
PURPOSE: The aim of this study was to determine the effect of single fraction (SF) and multiple fraction (MF) radiation therapy (RT) on bone mineral density (BMD) in patients with cancer and bone metastases in the proximal femur. We studied this effect in the radiation field and within metastatic lesions, and differentiated between lytic, blastic, and mixed lesions. METHODS AND MATERIALS: This prospective cohort study comprised 42 patients with painful bone metastases, including 47 irradiated femora with 52 metastatic lesions in the proximal femur...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28724081/genome-wide-screening-for-lectin-motifs-in-arabidopsis-thaliana
#17
Lore Eggermont, Bruno Verstraeten, Els J M Van Damme
For more than three decades, served as a model for plant biology research. At present only a few protein families have been studied in detail in . This study focused on all sequences with lectin motifs in the genome of . Based on amino acid sequence similarity (BLASTp searches), 217 putative lectin genes were retrieved belonging to 9 out of 12 different lectin families. The domain organization and genomic distribution for each lectin family were analyzed. Domain architecture analysis revealed that most of these lectin gene sequences are linked to other domains, often belonging to protein families with catalytic activity...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28670263/tone-burst-electrocochleography-for-the-diagnosis-of-clinically-certain-meniere-s-disease
#18
REVIEW
Jeremy Hornibrook
The technique of transtympanic electrocochleography was initially developed as an objective hearing threshold test by Eggermont. Gibson et al. (1977) claimed that an enlarged direct current component of the action potential (AP) called the summating potential (SP) is an indication of endolymphatic hydrops, later confirmed by Coates who proposed an SP/AP ratio measure. This led to numerous publications using diagnostic ratios of 0.33-0.35. The insensitivity led to an eventual disenchantment with the test as a reliable objective test for Meniere's disease...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28662904/corrigendum-to-cost-effectiveness-analysis-in-melanoma-detection-a-transition-model-applied-to-dermoscopy-eur-j-cancer-67-2016-38-45
#19
Isabelle Tromme, Catherine Legrand, Brecht Devleesschauwer, Ulrike Leiter, Stefan Suciu, Alexander Eggermont, Laurine Sacré, Jean-François Baurain, Luc Thomas, Philippe Beutels, Niko Speybroeck
No abstract text is available yet for this article.
June 26, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28623775/cancer-immunotherapy-opportunities-and-challenges-in-the-rapidly-evolving-clinical-landscape
#20
REVIEW
Leisha A Emens, Paolo A Ascierto, Phillip K Darcy, Sandra Demaria, Alexander M M Eggermont, William L Redmond, Barbara Seliger, Francesco M Marincola
Cancer immunotherapy is now established as a powerful way to treat cancer. The recent clinical success of immune checkpoint blockade (antagonists of CTLA-4, PD-1 and PD-L1) highlights both the universal power of treating the immune system across tumour types and the unique features of cancer immunotherapy. Immune-related adverse events, atypical clinical response patterns, durable responses, and clear overall survival benefit distinguish cancer immunotherapy from cytotoxic cancer therapy. Combination immunotherapies that transform non-responders to responders are under rapid development...
August 2017: European Journal of Cancer
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