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https://www.readbyqxmd.com/read/27895575/can-animal-models-contribute-to-understanding-tinnitus-heterogeneity-in-humans
#1
REVIEW
Jos J Eggermont
The brain activity of humans with tinnitus of various etiologies is typically studied with electro- and magneto-encephalography and functional magnetic resonance imaging-based imaging techniques. Consequently, they measure population responses and mostly from the neocortex. The latter also underlies changes in neural networks that may be attributed to tinnitus. However, factors not strictly related to tinnitus such as hearing loss and hyperacusis, as well as other co-occurring disorders play a prominent role in these changes...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27853641/melanomas-prevent-endothelial-cell-death-under-restrictive-culture-conditions-by-signaling-through-akt-and-p38-mapk-erk-1-2-cascades
#2
Asha M Das, Mario Pescatori, Cindy E Vermeulen, Joost A P Rens, Ann L B Seynhaeve, Gerben A Koning, Alexander M M Eggermont, Timo L M Ten Hagen
Although melanoma progression and staging is clinically well characterized, a large variation is observed in pathogenesis, progression, and therapeutic responses. Clearly, intrinsic characteristics of melanoma cells contribute to this variety. An important factor, in both progression of the disease and response to therapy, is the tumor-associated vasculature. We postulate that melanoma cells communicate with endothelial cells (ECs) in order to establish a functional and supportive blood supply. We investigated the angiogenic potential of human melanoma cell lines by monitoring the survival of ECs upon exposure to melanoma conditioned medium (CM), under restrictive conditions...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27846884/future-perspectives-in-melanoma-research-meeting-report-from-the-melanoma-bridge-napoli-december-1st-4th-2015
#3
Paolo A Ascierto, Sanjiv Agarwala, Gerardo Botti, Alessandra Cesano, Gennaro Ciliberto, Michael A Davies, Sandra Demaria, Reinhard Dummer, Alexander M Eggermont, Soldano Ferrone, Yang Xin Fu, Thomas F Gajewski, Claus Garbe, Veronica Huber, Samir Khleif, Michael Krauthammer, Roger S Lo, Giuseppe Masucci, Giuseppe Palmieri, Michael Postow, Igor Puzanov, Ann Silk, Stefani Spranger, David F Stroncek, Ahmad Tarhini, Janis M Taube, Alessandro Testori, Ena Wang, Jennifer A Wargo, Cassian Yee, Hassane Zarour, Laurence Zitvogel, Bernard A Fox, Nicola Mozzillo, Francesco M Marincola, Magdalena Thurin
The sixth "Melanoma Bridge Meeting" took place in Naples, Italy, December 1st-4th, 2015. The four sessions at this meeting were focused on: (1) molecular and immune advances; (2) combination therapies; (3) news in immunotherapy; and 4) tumor microenvironment and biomarkers. Recent advances in tumor biology and immunology has led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS) and overall survival (OS) of cancer patients. Immunotherapies in particular have emerged as highly successful approaches to treat patients with cancer including melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), bladder cancer, and Hodgkin's disease...
November 15, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27836854/a-novel-spectroscopically-determined-pharmacodynamic-biomarker-for-skin-toxicity-in-cancer-patients-treated-with-targeted-agents
#4
Antoine Azan, Peter J Caspers, Tom C Bakker Schut, Séverine Roy, Céline Boutros, Christine Mateus, Emilie Routier, Benjamin Besse, David Planchard, Atmane Seck, Nyam Kamsu-Kom, Gorana Tomasic, Senada Koljenović, Vincent Noordhoek Hegt, Texier Matthieu, Emilie Lanoy, Alexander M Eggermont, Angelo Paci, Caroline Robert, Gerwin J Puppels, Lluis M Mir
Raman spectroscopy is a non-invasive and label-free optical technique that provides detailed information about the molecular composition of a sample. In this study, we evaluated the potential of Raman spectroscopy to predict skin toxicity due to tyrosine-kinase inhibitors treatment. We acquired Raman spectra of skin of patients undergoing treatment with MEK, EGFR or BRAF inhibitors which are known to induce severe skin toxicity; for this pilot study, three patients were included for each inhibitor. Our algorithm, based on Partial Least Squares-Discriminant Analysis (PLS-DA) and cross-validation by bootstrapping, discriminated to variable degrees spectra from patient suffering and not suffering cutaneous adverse events...
November 11, 2016: Cancer Research
https://www.readbyqxmd.com/read/27827313/hyperprogressive-disease-hpd-is-a-new-pattern-of-progression-in-cancer-patients-treated-by-anti-pd-1-pd-l1
#5
Stephane Champiat, Laurent Dercle, Samy Ammari, Christophe Massard, Antoine Hollebecque, Sophie Postel-Vinay, Nathalie Chaput, Alexander M Eggermont, Aurélien Marabelle, Jean-Charles Soria, Charles Ferté
Purpose While Immune checkpoint inhibitors are disrupting the management of cancer patients, anecdotal occurrences of rapid progression (i.e. hyperprogressive disease or HPD) under these agents have been described, suggesting potentially deleterious effects of these drugs. The prevalence, the natural history and the predictive factors of HPD in cancer patients treated by anti PD-1/PD-L1 remain unknown. Experimental design Medical records from all patients (N =218) prospectively treated in Gustave Roussy by anti PD-1/PD-L1 within phase I clinical trials were analyzed...
November 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27816830/adjuvant-ipilimumab-in-stage-iii-melanoma-new-landscape-new-questions
#6
Alexander M M Eggermont
The recently reported significant prolongation of overall survival with ipilimumab as adjuvant in high-risk stage III melanoma patients represents an important event in the adjuvant treatment landscape. The European Organisation for Research and Treatment of Cancer 18071 trial demonstrated a 28% reduction in risk of death in patients treated with ipilimumab at 10 mg/kg (hazard ratio for death, 0.72; 95.1% CI, 0.58-0.88; P = 0.001) compared with placebo. All end-points-recurrence-free survival (RFS), distant-metastasis-free survival (DMFS) and overall survival (OS)-showed similar benefits...
November 3, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27793584/effects-of-long-term-non-traumatic-noise-exposure-on-the-adult-central-auditory-system-hearing-problems-without-hearing-loss
#7
REVIEW
Jos J Eggermont
It is known that hearing loss induces plastic changes in the brain, causing loudness recruitment and hyperacusis, increased spontaneous firing rates and neural synchrony, reorganizations of the cortical tonotopic maps, and tinnitus. Much less in known about the central effects of exposure to sounds that cause a temporary hearing loss, affect the ribbon synapses in the inner hair cells, and cause a loss of high-threshold auditory nerve fibers. In contrast there is a wealth of information about central effects of long-duration sound exposures at levels ≤ 80 dB SPL that do not even cause a temporary hearing loss...
October 25, 2016: Hearing Research
https://www.readbyqxmd.com/read/27757313/trial-watch-immunotherapy-plus-radiation-therapy-for-oncological-indications
#8
REVIEW
Erika Vacchelli, Norma Bloy, Fernando Aranda, Aitziber Buqué, Isabelle Cremer, Sandra Demaria, Alexander Eggermont, Silvia Chiara Formenti, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi
Malignant cells succumbing to some forms of radiation therapy are particularly immunogenic and hence can initiate a therapeutically relevant adaptive immune response. This reflects the intrinsic antigenicity of malignant cells (which often synthesize a high number of potentially reactive neo-antigens) coupled with the ability of radiation therapy to boost the adjuvanticity of cell death as it stimulates the release of endogenous adjuvants from dying cells. Thus, radiation therapy has been intensively investigated for its capacity to improve the therapeutic profile of several anticancer immunotherapies, including (but not limited to) checkpoint blockers, anticancer vaccines, oncolytic viruses, Toll-like receptor (TLR) agonists, cytokines, and several small molecules with immunostimulatory effects...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27725525/impact-of-implantation-technique-and-plaque-morphology-on-strut-embedment-and-scaffold-expansion-of-polylactide-bioresorbable-scaffold%C3%A3-insights-from-absorb-japan-trial
#9
Yohei Sotomi, Yoshinobu Onuma, Jouke Dijkstra, Jeroen Eggermont, Shengnan Liu, Erhan Tenekecioglu, Yaping Zeng, Taku Asano, Robbert J de Winter, Jeffrey J Popma, Ken Kozuma, Kengo Tanabe, Patrick W Serruys, Takeshi Kimura
BACKGROUND: The optimal implantation technique for the bioresorbable scaffold (Absorb, Abbott Vascular) is still a matter of debate. The purpose of the present study was to evaluate the effect of implantation technique on strut embedment and scaffold expansion.Methods and Results:Strut embedment depth and scaffold expansion index assessed by optical coherence tomography (OCT) (minimum scaffold area/reference vessel area) were evaluated in the ABSORB Japan trial (OCT subgroup: 87 lesions) with respect to implantation technique using either quantitative coronary angiography (QCA) or OCT...
October 8, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27717298/prolonged-survival-in-stage-iii-melanoma-with-ipilimumab-adjuvant-therapy
#10
Alexander M M Eggermont, Vanna Chiarion-Sileni, Jean-Jacques Grob, Reinhard Dummer, Jedd D Wolchok, Henrik Schmidt, Omid Hamid, Caroline Robert, Paolo A Ascierto, Jon M Richards, Céleste Lebbé, Virginia Ferraresi, Michael Smylie, Jeffrey S Weber, Michele Maio, Lars Bastholt, Laurent Mortier, Luc Thomas, Saad Tahir, Axel Hauschild, Jessica C Hassel, F Stephen Hodi, Corina Taitt, Veerle de Pril, Gaetan de Schaetzen, Stefan Suciu, Alessandro Testori
Background On the basis of data from a phase 2 trial that compared the checkpoint inhibitor ipilimumab at doses of 0.3 mg, 3 mg, and 10 mg per kilogram of body weight in patients with advanced melanoma, this phase 3 trial evaluated ipilimumab at a dose of 10 mg per kilogram in patients who had undergone complete resection of stage III melanoma. Methods After patients had undergone complete resection of stage III cutaneous melanoma, we randomly assigned them to receive ipilimumab at a dose of 10 mg per kilogram (475 patients) or placebo (476) every 3 weeks for four doses, then every 3 months for up to 3 years or until disease recurrence or an unacceptable level of toxic effects occurred...
October 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27716048/glycan-binding-f-box-protein-from-arabidopsis-thaliana-protects-plants-from-pseudomonas-syringae-infection
#11
Karolina Stefanowicz, Nausicaä Lannoo, Yafei Zhao, Lore Eggermont, Jonas Van Hove, Bassam Al Atalah, Els J M Van Damme
BACKGROUND: A small group of F-box proteins consisting of a conserved F-box domain linked to a domain homologous to the glycan-binding protein has been identified within the genome of Arabidopsis thaliana. Previously, the so-called F-box-Nictaba protein, encoded by the gene At2g02360, was shown to be a functional lectin which binds N-acetyllactosamine structures. Here, we present a detailed qRT-PCR expression analysis of F-box-Nictaba in Arabidopsis plants upon different stresses and hormone treatments...
October 4, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27669503/effects-of-time-interval-between-primary-melanoma-excision-and-sentinel-node-biopsy-on-positivity-rate-and-survival
#12
Charlotte M C Oude Ophuis, Alexander C J van Akkooi, Piotr Rutkowski, Christiane A Voit, Joanna Stepniak, Nicole S Erler, Alexander M M Eggermont, Michel W J M Wouters, Dirk J Grünhagen, Cornelis Kees Verhoef
BACKGROUND: Sentinel node biopsy (SNB) is essential for adequate melanoma staging. Most melanoma guidelines advocate to perform wide local excision and SNB as soon as possible, causing time pressure. OBJECTIVE: To investigate the role of time interval between melanoma diagnosis and SNB on sentinel node (SN) positivity and survival. METHODS: This is a retrospective observational study concerning a cohort of melanoma patients from four European Organization for Research and Treatment of Cancer Melanoma Group tertiary referral centres from 1997 to 2013...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27611606/development-and-validation-of-a-quantitative-snack-and-beverage-food-frequency-questionnaire-for-adolescents
#13
N De Cock, J Van Camp, P Kolsteren, C Lachat, L Huybregts, L Maes, B Deforche, R Verstraeten, J Vangeel, K Beullens, S Eggermont, W Van Lippevelde
BACKGROUND: A short, reliable and valid tool to measure snack and beverage consumption in adolescents, taking into account the correct definitions, would benefit both epidemiological and intervention research. The present study aimed to develop a short quantitative beverage and snack food frequency questionnaire (FFQ) and to assess the reliability and validity of this FFQ against three 24-h recalls. METHODS: Reliability was assessed by comparing estimates of the FFQ administered 14 days apart (FFQ1 and FFQ2) in a convenience sample of 179 adolescents [60...
September 9, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27592070/cost-effectiveness-analysis-in-melanoma-detection-a-transition-model-applied-to-dermoscopy
#14
Isabelle Tromme, Catherine Legrand, Brecht Devleesschauwer, Ulrike Leiter, Stefan Suciu, Alexander Eggermont, Laurine Sacré, Jean-François Baurain, Luc Thomas, Philippe Beutels, Niko Speybroeck
AIM: The main aim of this study is to demonstrate how our melanoma disease model (MDM) can be used for cost-effectiveness analyses (CEAs) in the melanoma detection field. In particular, we used the data of two cohorts of Belgian melanoma patients to investigate the cost-effectiveness of dermoscopy. METHODS: A MDM, previously constructed to calculate the melanoma burden, was slightly modified to be suitable for CEAs. Two cohorts of patients entered into the model to calculate morbidity, mortality and costs...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27585534/gender-and-facebook-motives-as-predictors-of-specific-types-of-facebook-use-a-latent-growth-curve-analysis-in-adolescence
#15
Eline Frison, Steven Eggermont
Despite increasing evidence that specific types of Facebook use (i.e., active private, active public, and passive Facebook use) are differently related to adolescents' well-being, little is known how these types function over the course of adolescence and whether gender and Facebook motives may predict the initial level and changes in these types over time. To address these gaps, Flemish adolescents (ages 12-19) were questioned at three different time points, with six months in between (NTime1 = 1866). Latent growth curve models revealed that active private Facebook use increased over the course of adolescence, whereas public Facebook use decreased...
October 2016: Journal of Adolescence
https://www.readbyqxmd.com/read/27562777/factors-influencing-the-reinforcing-value-of-fruit-and-unhealthy-snacks
#16
L Vervoort, A Clauwaert, L Vandeweghe, J Vangeel, W Van Lippevelde, L Goossens, L Huybregts, C Lachat, S Eggermont, K Beullens, C Braet, N De Cock
OBJECTIVE: The present study investigated the reinforcing value of healthy and unhealthy snack food in adolescents (n = 108, aged 14-16 years). Moderation by access to different foods, sex and the personality trait reward sensitivity is tested. METHODS: In a computerized Food Reinforcement Task, adolescents could earn portions of a healthy and an unhealthy snack following an identical progressive reinforcement schedule for both food types. Reinforcing value of food was indexed by the number of button presses for each food type...
August 25, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27522248/tissue-inhibitor-of-metalloproteinase-3-timp3-expression-decreases-during-melanoma-progression-and-inhibits-melanoma-cell-migration
#17
Asha M Das, Michiel Bolkestein, Thom van der Klok, Charlotte M C Oude Ophuis, Cindy E Vermeulen, Joost A P Rens, Winand N M Dinjens, Peggy N Atmodimedjo, Cornelis Verhoef, Senada Koljenović, Ron Smits, Timo L M Ten Hagen, Alexander M M Eggermont
AIMS: Malignant melanoma is the most aggressive form of skin cancer, and metastatic dissemination to regional and visceral sites is responsible for the majority of melanoma-related mortalities. In a recent study by our group, we observed reduced expression of tissue inhibitor of metalloproteinase-3 (TIMP3) in the majority of stage III melanoma samples studied. TIMP3 has been reported as a tumour suppressor in several human malignancies, with reduced expression correlating with poor clinical outcome...
October 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27494932/using-a-gamified-monitoring-app-to-change-adolescents-snack-intake-the-development-of-the-reward-app-and-evaluation-design
#18
W Van Lippevelde, J Vangeel, N De Cock, C Lachat, L Goossens, K Beullens, L Vervoort, C Braet, L Maes, S Eggermont, B Deforche, J Van Camp
BACKGROUND: As the snacking pattern of European adolescents is of great concern, effective interventions are necessary. Till now health promotion efforts in children and adolescents have had only limited success in changing adolescents' eating patterns and anthropometrics. Therefore, the present study proposes an innovative approach to influence dietary behaviors in youth based on new insights on effective behavior change strategies and attractive intervention channels to engage adolescents...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27477635/h3k27me3-does-not-orchestrate-the-expression-of-lineage-specific-markers-in-hesc-derived-hepatocytes-in%C3%A2-vitro
#19
Jolien Vanhove, Mariaelena Pistoni, Marc Welters, Kristel Eggermont, Veerle Vanslembrouck, Nicky Helsen, Ruben Boon, Mustapha Najimi, Etienne Sokal, Philippe Collas, J Willem Voncken, Catherine M Verfaillie
Although pluripotent stem cells can be differentiated into the hepatocyte lineages, such cells retain an immature phenotype. As the chromatin state of regulatory regions controls spatiotemporal gene expression during development, we evaluated changes in epigenetic histone marks in lineage-specific genes throughout in vitro hepatocyte differentiation from human embryonic stem cells (hESCs). Active acetylation and methylation marks at promoters and enhancers correlated with progressive changes in gene expression...
August 9, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27446503/investigation-of-particle-accumulation-chemosensitivity-and-thermosensitivity-for-effective-solid-tumor-therapy-using-thermosensitive-liposomes-and-hyperthermia
#20
Wouter J M Lokerse, Michiel Bolkestein, Timo L M Ten Hagen, Marion de Jong, Alexander M M Eggermont, Holger Grüll, Gerben A Koning
Doxorubicin (Dox) loaded thermosensitive liposomes (TSLs) have shown promising results for hyperthermia-induced local drug delivery to solid tumors. Typically, the tumor is heated to hyperthermic temperatures (41-42 °C), which induced intravascular drug release from TSLs within the tumor tissue leading to high local drug concentrations (1-step delivery protocol). Next to providing a trigger for drug release, hyperthermia (HT) has been shown to be cytotoxic to tumor tissue, to enhance chemosensitivity and to increase particle extravasation from the vasculature into the tumor interstitial space...
2016: Theranostics
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