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https://www.readbyqxmd.com/read/29451373/regional-structural-and-functional-specialisations-in-the-urethra-of-the-female-rat-evidence-for-complex-physiological-control-systems
#1
Monica Eggermont, Stefan De Wachter, Jane Eastham, James Gillespie
The present study characterises the complex structural and functional elements of the female rat urethra that may be involved in controlling urethral closure and continence. Urethras were dissected from female Sprague-Dawley rats (n=12) euthanized by pentobarbital overdose. Tissues were fixed (4% paraformaldehyde), frozen and sectioned (8μm) for light microscopy and immunohistochemistry. Antibodies were used to detect immunoreactivity to calcitonin gene related peptide, nitric oxide synthase, vesicular acetylcholine transporter and tyrosine hydroxylase...
February 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29432281/lymph-node-ratio-as-a-prognostic-factor-in-melanoma-results-from-european-organization-for-research-and-treatment-of-cancer-18871-18952-and-18991-studies
#2
Alessandro A Testori, Stefan Suciu, Alexander C J van Akkooi, Mariano Suppa, Alexander M M Eggermont, Esther de Vries, Arjen Joosse
The aim of this study was to assess the prognostic importance of lymph node ratio (LNR) in stage III melanoma after complete lymph nodal dissections. From European Organization for Research and Treatment of Cancer randomized trials 18871, 18952, and 18991, 2358 patients had full information on positive and examined lymph nodes (LNs) and were included. Cox proportional hazards models stratified by trial were used to assess the prognostic impact of LNR adjusted for confounders on melanoma-specific survival. Optimal cutoff values for LNR were calculated for each LN dissection site (axillary, inguinal, and neck)...
February 9, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29361473/neoadjuvant-therapy-in-melanoma-the-next-step
#3
Paolo A Ascierto, Alexander M M Eggermont
No abstract text is available yet for this article.
January 17, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29337119/sox10-single-transcription-factor-based-fast-and-efficient-generation-of%C3%A2-oligodendrocytes-from-human-pluripotent-stem-cells
#4
Juan Antonio García-León, Manoj Kumar, Ruben Boon, David Chau, Jennifer One, Esther Wolfs, Kristel Eggermont, Pieter Berckmans, Nilhan Gunhanlar, Femke de Vrij, Bas Lendemeijer, Benjamin Pavie, Nikky Corthout, Steven A Kushner, José Carlos Dávila, Ivo Lambrichts, Wei-Shou Hu, Catherine M Verfaillie
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our understanding of OL biology and the development of novel therapies. Here, we demonstrate that overexpression of the transcription factor SOX10 is sufficient to generate surface antigen O4-positive (O4+) and myelin basic protein-positive OLs from hPSCs in only 22 days, including from patients with multiple sclerosis or amyotrophic lateral sclerosis. The SOX10-induced O4+ population resembles primary human OLs at the transcriptome level and can myelinate neurons in vivo...
January 10, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29312568/transcriptional-response-to-hypoxic-stress-in-melanoma-and-prognostic-potential-of-gbe1-and-bnip3
#5
Stéphanie Buart, Stéphane Terry, Muhammad Z Noman, Emilie Lanoy, Céline Boutros, Paul Fogel, Philippe Dessen, Guillaume Meurice, Yann Gaston-Mathé, Philippe Vielh, Séverine Roy, Emilie Routier, Virginie Marty, Sophie Ferlicot, Luc Legrès, Morad El Bouchtaoui, Nyam Kamsu-Kom, Jane Muret, Eric Deutsch, Alexander Eggermont, Jean-Charles Soria, Caroline Robert, Salem Chouaib
Gradients of hypoxia occur in most solid tumors and cells found in hypoxic regions are associated with the most aggressive and therapy-resistant fractions of the tumor. Despite the ubiquity and importance of hypoxia responses, little is known about the variation in the global transcriptional response to hypoxia in melanoma. Using microarray technology, whole genome gene expression profiling was first performed on established melanoma cell lines. From gene set enrichment analyses, we derived a robust 35 probes signature (hypomel for HYPOxia MELanoma) associated with hypoxia-response pathways, including 26 genes up regulated, and 9 genes down regulated...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29171676/tween-television-and-peers-reinforcing-social-agents-in-early-adolescents-body-surveillance-and-self-objectification
#6
Ann Rousseau, Steven Eggermont
Sociocultural models of body image posit that the media and peers play a role in early adolescents' body dissatisfaction. Introducing a sociocultural perspective on youth sexualization, the present three-wave panel study (N = 968, Mage  = 11.30) sought to examine the role of tween television and peer appearance conversations in early adolescents' body surveillance and self-objectification over time. Special attention was given to the mediating role of media internalization in these relationships. The results showed evidence for a reciprocal interaction between media internalization and peer appearance conversations and identified this reciprocal interaction as the underlying mechanism linking tween television exposure to higher levels of body surveillance and self-objectification 1 year later...
November 24, 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29152869/linking-magazine-exposure-to-social-appearance-anxiety-the-role-of-appearance-norms-in-early-adolescence
#7
Jolien Trekels, Steven Eggermont
Early adolescents (N = 1,591; Mage  = 11.698; SD = 0.892) participated in a two-wave panel study (6-month interval) to examine the longitudinal association between appearance-focused magazine exposure and social appearance anxiety. We revealed that magazine exposure positively correlated with the internalization of appearance ideals and the attribution of social rewards to attractiveness which, in turn, related to social appearance anxiety. Internalization and attribution of social rewards formed a reinforcing spiral; once internalized, early adolescents associate positive things with appearance ideals (e...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29100546/the-need-for-a-network-to-establish-and-validate-predictive-biomarkers-in-cancer-immunotherapy
#8
EDITORIAL
Giuseppe V Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A Fox, Ena Wang, Francesco M Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H Butterfield, Lisa Villabona, Magdalena Thurin, Michael A Postow, Paul M Sondel, Sandra Demaria, Sanjiv Agarwala, Paolo A Ascierto
Immunotherapies have emerged as one of the most promising approaches to treat patients with cancer. Recently, the entire medical oncology field has been revolutionized by the introduction of immune checkpoints inhibitors. Despite success in a variety of malignancies, responses typically only occur in a small percentage of patients for any given histology or treatment regimen. There are also concerns that immunotherapies are associated with immune-related toxicity as well as high costs. As such, identifying biomarkers to determine which patients are likely to derive clinical benefit from which immunotherapy and/or be susceptible to adverse side effects is a compelling clinical and social need...
November 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29097494/gut-microbiome-influences-efficacy-of-pd-1-based-immunotherapy-against-epithelial-tumors
#9
Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P M Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein, Kristina Iribarren, Laura Mondragón, Nicolas Jacquelot, Bo Qu, Gladys Ferrere, Céline Clémenson, Laura Mezquita, Jordi Remon Masip, Charles Naltet, Solenn Brosseau, Coureche Kaderbhai, Corentin Richard, Hira Rizvi, Florence Levenez, Nathalie Galleron, Benoit Quinquis, Nicolas Pons, Bernhard Ryffel, Véronique Minard-Colin, Patrick Gonin, Jean-Charles Soria, Eric Deutsch, Yohann Loriot, François Ghiringhelli, Gérard Zalcman, François Goldwasser, Bernard Escudier, Matthew D Hellmann, Alexander Eggermont, Didier Raoult, Laurence Albiges, Guido Kroemer, Laurence Zitvogel
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition. Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer. Fecal microbiota transplantation (FMT) from cancer patients who responded to ICIs into germ-free or antibiotic-treated mice ameliorated the antitumor effects of PD-1 blockade, whereas FMT from nonresponding patients failed to do so...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29095202/simultaneous-inhibition-of-tumor-necrosis-factor-receptor-1-and-matrix-metalloproteinase-8-completely-protects-against-acute-inflammation-and-sepsis
#10
Sophie Steeland, Sara Van Ryckeghem, Jolien Vandewalle, Marlies Ballegeer, Elien Van Wonterghem, Melanie Eggermont, Johan Decruyenaere, Liesbet De Bus, Claude Libert, Roosmarijn E Vandenbroucke
OBJECTIVES: Sepsis causes very high mortality and morbidity rates and remains one of the biggest medical challenges. This study investigates whether plasma levels of both matrix metalloproteinase 8 and tumor necrosis factor receptor 1 are associated with sepsis severity and also investigates the therapeutic applicability of simultaneous inhibition of the two molecules in sepsis. DESIGN: Observational human pilot study-prospective controlled animal study. SETTING: University hospital and research laboratory...
October 31, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29095056/-i-can-should-look-like-a-media-figure-the-association-between-direct-and-indirect-media-exposure-and-teens-sexualizing-appearance-behaviors
#11
Jolien Trekels, Steven Eggermont
Prior research has examined the influence of media exposure on adolescents' sexualized self-concept, but engagement in sexualizing appearance behaviors remains understudied, especially among a younger age group (i.e., early adolescents). This three-wave panel study among 971 nine- to 14-year-olds (Mage = 12.99, SD = 1.03) showed that discussing media content with friends (i.e., indirect media exposure) was indirectly related to sexualizing appearance behaviors through perceived attainability of the appearance ideal...
November 2, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/29039700/browsing-posting-and-liking-on-instagram-the-reciprocal-relationships-between-different-types-of-instagram-use-and-adolescents-depressed-mood
#12
Eline Frison, Steven Eggermont
Although studies have shown that Instagram use and young adults' mental health are cross-sectionally associated, longitudinal evidence is lacking. In addition, no study thus far examined this association, or the reverse, among adolescents. To address these gaps, we set up a longitudinal panel study among 12- to 19-year-old Flemish adolescents to investigate the reciprocal relationships between different types of Instagram use and depressed mood. Self-report data from 671 adolescent Instagram users (61% girls; MAge = 14...
October 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29028110/melanoma-staging-evidence-based-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#13
Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson
Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria...
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28968566/the-2017-complete-overhaul-of-adjuvant-therapies-for-high-risk-melanoma-and-its-consequences-for-staging-and-management-of-melanoma-patients
#14
Alexander M M Eggermont, Reinhard Dummer
The spectacular outcomes of the phase III trials regarding nivolumab versus ipilimumab in fully resected stage IIIB/C-IV and of the combination of dabrafenib (D) plus trametinib (T) in BRAF-mutant stage III patients demonstrate that effective treatments in advanced melanoma are also highly effective in the adjuvant setting. In 2016, an overall survival benefit with adjuvant high-dose ipilimumab was demonstrated, and the European Organisation for Research and Treatment of Cancer trial 1325 comparing pembrolizumab versus placebo will complete the picture in the early 2018...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28941782/level-of-parenting-stress-in-mothers-of-singletons-and-mothers-of-twins-until-one-year-postpartum-a-cross-sectional-study
#15
Marjon De Roose, Dimitri Beeckman, Katrijn Eggermont, Elke Vanhouche, Ann Van Hecke, Sofie Verhaeghe
PROBLEM: To date, it is unclear which factors are associated with parenting stress. BACKGROUND: There are no studies investigating the association between parenting stress and coping strategies such as coparenting and social support, while simultaneously considering demographic and obstetric factors, in mothers of singletons and twins. AIM: To investigate if parenting stress is associated with personal, and obstetric characteristics, the level of coparenting, and the availability of and satisfaction with social support in mothers of singletons and twins until one year postpartum...
September 20, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28928380/predictors-of-responses-to-immune-checkpoint-blockade-in-advanced-melanoma
#16
N Jacquelot, M P Roberti, D P Enot, S Rusakiewicz, N Ternès, S Jegou, D M Woods, A L Sodré, M Hansen, Y Meirow, M Sade-Feldman, A Burra, S S Kwek, C Flament, M Messaoudene, C P M Duong, L Chen, B S Kwon, A C Anderson, V K Kuchroo, B Weide, F Aubin, C Borg, S Dalle, O Beatrix, M Ayyoub, B Balme, G Tomasic, A M Di Giacomo, M Maio, D Schadendorf, I Melero, B Dréno, A Khammari, R Dummer, M Levesque, Y Koguchi, L Fong, M Lotem, M Baniyash, H Schmidt, I M Svane, G Kroemer, A Marabelle, S Michiels, A Cavalcanti, M J Smyth, J S Weber, A M Eggermont, L Zitvogel
Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-based approach to an assessment of 779 paired blood and tumor markers in 37 stage III MMel patients, we analyzed association between blood immune parameters and the functional immune reactivity of tumor-infiltrating cells after ex vivo exposure to ICB...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28922786/relapse-free-survival-as-a-surrogate-for-overall-survival-in-the-evaluation-of-stage-ii-iii-melanoma-adjuvant-therapy
#17
REVIEW
Stefan Suciu, Alexander M M Eggermont, Paul Lorigan, John M Kirkwood, Svetomir N Markovic, Claus Garbe, David Cameron, Srividya Kotapati, Tai-Tsang Chen, Keith Wheatley, Natalie Ives, Gaetan de Schaetzen, Achmad Efendi, Marc Buyse
Background: We assessed whether relapse-free survival (RFS; time until recurrence/death) is a valid surrogate for overall survival (OS) among resected stage II-III melanoma patients through a meta-analysis of randomized controlled trials. Methods: Individual patient data (IPD) on RFS and OS were collected from 5826 patients enrolled in 11 randomized adjuvant trials comparing interferon (IFN) to observation. In addition, IPD from two studies comparing IFN and vaccination in 989 patients were included...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28901053/tissue-characterization-with-depth-resolved-attenuation-coefficient-and-backscatter-term-in-intravascular-optical-coherence-tomography-images
#18
Shengnan Liu, Yohei Sotomi, Jeroen Eggermont, Gaku Nakazawa, Sho Torii, Takeshi Ijichi, Yoshinobu Onuma, Patrick W Serruys, Boudewijn P F Lelieveldt, Jouke Dijkstra
An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different atherosclerotic tissue types with a robust implementation of depth-resolved (DR) approach. Therefore, the DR model is introduced to estimate the attenuation coefficient and further extended to estimate the backscatter-related term in IVOCT images, such that values can be estimated per pixel without predefining any delineation for the estimation...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28846388/affinity-based-purification-of-polyisocyanopeptide-bioconjugates
#19
Roel Hammink, Loek J Eggermont, Themistoklis Zisis, Jurjen Tel, Carl G Figdor, Alan E Rowan, Kerstin G Blank
Water-soluble polyisocyanopeptides (PICs) are a new class of synthetic polymers that mimic natural protein-based filaments. Their unique semiflexible properties combined with a length of several hundred nanometers have recently enabled a number of biomedical applications ranging from tissue engineering to cancer immunotherapy. One crucial step toward the further development of PICs for these applications is the efficient and controlled synthesis and purification of PIC-biomolecule conjugates. Considering the large size of PICs and the biomolecules to be conjugated, conjugation reactions do usually not proceed to completion due to steric effects...
October 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28750266/the-role-of-appearance-schematicity-in-the-internalization-of-media-appearance-ideals-a-panel-study-of-preadolescents
#20
Ann Rousseau, Hilary Gamble, Steven Eggermont
Individuals who are more strongly invested in their appearance, appearance schematics, have a tendency to engage in appearance-related comparison. Appearance schematicity consists of two components. The self-evaluative component concerns the degree to which appearance is central to self-worth, referred to as dysfunctional appearance beliefs. Motivational salience refers to the engagement in behaviors designed to enhance appearance, such as body surveillance. Based on a three-wave panel survey of 973 Flemish preadolescents (Mage = 11...
October 2017: Journal of Adolescence
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