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https://www.readbyqxmd.com/read/27876465/is-there-still-a-role-for-irrigation-and-debridement-with-liner-exchange-in-acute-periprosthetic-total-knee-infection
#1
Andrés F Duque, Zachary D Post, Rex W Lutz, Fabio R Orozco, Sergio H Pulido, Alvin C Ong
BACKGROUND: Periprosthetic joint infection (PJI) is an important cause of failure in total knee arthroplasty. Irrigation and debridement including liner exchange (I&D/L) success rates have varied for acute PJI. The purpose of this study is to present results of a specific protocol for I&D/L with retention of total knee arthroplasty components. METHODS: Sixty-seven consecutive I&D/L patients were retrospectively evaluated. Inclusion criteria for I&D/L were as follows: fewer than 3 weeks of symptoms, no immunologic compromise, intact soft tissue sleeve, and well-fixed components...
November 1, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27867375/ceftriaxone-pulse-dosing-fails-to-eradicate-biofilm-like-microcolony-b-burgdorferi-persisters-which-are-sterilized-by-daptomycin-doxycycline-cefuroxime-without-pulse-dosing
#2
Jie Feng, Shuo Zhang, Wanliang Shi, Ying Zhang
Although the majority of Lyme disease patients can be cured, at least 10-20% of the patients continue to suffer from persisting symptoms such as fatigue, muscular and joint pain, and neurologic impairment after standard 2-4 week antibiotic treatment. While the causes for this post-treatment Lyme disease symptoms are unclear, one possibility is due to Borrelia burgdorferi persisters that are not effectively killed by current antibiotics such as doxycycline or amoxicillin used to treat Lyme disease. A previous study showed that four rounds of ceftriaxone pulse dosing treatment eradicated B...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27825384/inhibiting-the-proton-pump-mechanisms-benefits-harms-and-questions
#3
Jeffrey K Aronson
Inhibition of the H(+)/K(+)-adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ulceration...
November 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27736840/progress-toward-global-eradication-of-dracunculiasis-january-2015-june-2016
#4
Donald R Hopkins, Ernesto Ruiz-Tiben, Mark L Eberhard, Sharon L Roy, Adam J Weiss
Dracunculiasis (Guinea worm disease) is caused by Dracunculus medinensis, a parasitic worm. Approximately 1 year after a person acquires infection from drinking contaminated water, the worm emerges through the skin, usually on the leg. Pain and secondary bacterial infection can cause temporary or permanent disability that disrupts work and schooling. The campaign to eradicate dracunculiasis worldwide began in 1980 at CDC. In 1986, the World Health Assembly called for dracunculiasis elimination (1), and the global Guinea Worm Eradication Program, led by the Carter Center and supported by the World Health Organization (WHO), United Nations Children's Fund (UNICEF), CDC, and other partners, began assisting ministries of health in countries where dracunculiasis was endemic...
October 14, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27708686/a-13-weeks-mindfulness-based-pain-management-program-improves-psychological-distress-in-patients-with-chronic-pain-compared-with-waiting-list-controls
#5
Tonny Elmose Andersen, Henrik Bjarke Vægter
BACKGROUND: Eradication of pain is seldom an option in chronic pain management. Hence, mindfulness meditation has become popular in pain management. OBJECTIVE: This pilot study compared the effect of a 13-weeks cognitive behavioural therapy program with integrated mindfulness meditation (CBTm) in patients with chronic non-malignant pain with a control condition. It was hypothesised that the CBTm program would reduce pain intensity and psychological distress compared to the control condition and that level of mindfulness and acceptance both would be associated with the reduction in pain intensity and psychological distress...
2016: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/27698967/the-effect-of-probiotic-plus-prebiotic-supplementation-on-the-tolerance-and-efficacy-of-helicobacter-pylori-eradication-quadruple-therapy-a-randomized-prospective-double-blind-controlled-trial
#6
Afshin Shafaghi, Aydin Pourkazemi, Mohsen Khosravani, Saba Fakhrie Asl, Alireza Amir Maafi, Zahra Atrkar Roshan, Jafar Abaspour Rahimabad
BACKGROUND Standard anti-Helicobacter pylori (H. pylori) treatment fails in the eradication of the organism in almost 10-35% of the patients and has different side effects. Recent studies have proposed that probiotic supplementations with or without prebiotic may improve the eradication rate and diminish the side effects, although it is still a controversial issue. We aimed to investigate the effect of probiotic with prebiotic supplementation on the eradication rate and side effects of anti H. pylori quadruple therapy...
July 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27698761/aminoglycoside-antibiotics-for-nih-category-ii-chronic-bacterial-prostatitis-a-single-cohort-study-with-one-year-follow-up
#7
Vittorio Magri, Emanuele Montanari, Emanuela Marras, Gianpaolo Perletti
Although fluoroquinolones are first-line agents for the treatment of National Institutes of Health (NIH) category II chronic bacterial prostatitis (CBP), therapy with these agents is not always feasible due to the increasing worldwide resistance of causative uropathogens. New therapeutic options are urgently required, as drugs such as β-lactam antibiotics distribute poorly to prostatic sites of infection and trimethoprim therapy is often unfeasible due to high resistance rates. The present study aimed to analyze the efficacy of aminoglycosides, administered to a cohort of 78 patients affected by fluoroquinolone-resistant CBP, or excluded from fluoroquinolone therapy due to various contraindications...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27648327/resection-and-resolution-of-bone-marrow-lesions-associated-with-an-improvement-of-pain-after-total-knee-replacement-a-novel-case-study-using-a-3-tesla-metal-artefact-reduction-mri-sequence
#8
Thomas Kurien, Robert Kerslake, Brett Haywood, Richard G Pearson, Brigitte E Scammell
We present our case report using a novel metal artefact reduction magnetic resonance imaging (MRI) sequence to observe resolution of subchondral bone marrow lesions (BMLs), which are strongly associated with pain, in a patient after total knee replacement surgery. Large BMLs were seen preoperatively on the 3-Tesla MRI scans in a patient with severe end stage OA awaiting total knee replacement surgery. Twelve months after surgery, using a novel metal artefact reduction MRI sequence, we were able to visualize the bone-prosthesis interface and found complete resection and resolution of these BMLs...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27603362/m%C3%A3-n%C3%A3-trier-disease-manifested-by-polyposis-and-involved-in-both-the-small-bowel-and-entire-colon-a-case-report
#9
Qiang Ding, Panpan Lu, Shuping Ding, Yuhui Fan, Wei Yan, Ying Wang, Dean Tian, Yujia Xia, Mei Liu
INTRODUCTION: Ménétrier disease (MD) is rare that is involved in both the small bowel and entire colon. THE MAIN SYMPTOMS AND THE IMPORTANT CLINICAL FINDINGS: We describe a case of a 76-year-old male patient whose clinical presentations include intermittent diarrhea, epigastric pain, nausea, vomiting, asitia, and weight loss. An endoscopy was performed showing a large number of irregular forms and different sizes of polypoid lesions in the gastrointestinal tract, which is rare for MD...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27598050/transarterial-embolization-of-peripheral-arteriovenous-malformations-with-ethylenevinyl-alcohol-copolymer-feasibility-technical-outcomes-and-clinical-outcomes
#10
Tom De Beule, Jan Vranckx, Peter Verhamme, Veerle Labarque, Marie-Anne Morren, Inge Fourneau, Geert Maleux
BACKGROUND: The technical and clinical outcomes of catheter-directed embolization for peripheral arteriovenous malformations (AVM) using Onyx® (ethylene-vinyl alcohol copolymer) are not well documented. The purpose of this study was to retrospectively assess the safety, technical outcomes and clinical outcomes of catheter-directed Onyx® embolisation for the treatment of symptomatic peripheral AVMs. PATIENTS AND METHODS: Demographics, (pre-)interventional clinical and radiological data were assessed...
September 6, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27597847/candidate-essential-genes-in-burkholderia-cenocepacia-j2315-identified-by-genome-wide-tradis
#11
Yee-Chin Wong, Moataz Abd El Ghany, Raeece Naeem, Kok-Wei Lee, Yung-Chie Tan, Arnab Pain, Sheila Nathan
Burkholderia cenocepacia infection often leads to fatal cepacia syndrome in cystic fibrosis patients. However, antibiotic therapy rarely results in complete eradication of the pathogen due to its intrinsic resistance to many clinically available antibiotics. Recent attention has turned to the identification of essential genes as the proteins encoded by these genes may serve as potential targets for development of novel antimicrobials. In this study, we utilized TraDIS (Transposon Directed Insertion-site Sequencing) as a genome-wide screening tool to facilitate the identification of B...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27546866/-reverse-hip-spacer-for-massive-distal-femur-defects-in-peri-prosthetic-knee-infections
#12
X Flores, M Vicente, S Haddad, C Amat, L Carrera, P S Corona
BACKGROUND: Bone loss in the distal femur is a common problem in knee revision surgeries. The problem is exacerbated in the context of an active infection. In extreme cases this bone loss could compromise the feasibility of a two-stage exchange protocol using dynamic spacers due to the inherent instability of this type of spacers. Use of a hip prefabricated spacer in a "reverse" way forming a ball-and- socket joint is a therapeutic option in cases of massive bone defect and infection...
August 18, 2016: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/27523653/antiseptic-with-modern-wound-dressings-in-the-treatment-of-venous-leg-ulcers-clinical-and-microbiological-aspects
#13
M Sopata, M Kucharzewski, E Tomaszewska
OBJECTIVE: To assess the impact of a two-period treatment on the clinical condition, bacteriological changes and results of treatment of venous leg ulcers (VLU) using octenidine dihydrochloride. METHOD: Patients with a VLU were recruited and treated with octenidine dihydrochloride for one month, after which they were randomised and treated with hydrocolloids or foam dressings. The wounds were clinically assessed for the amount of necrotic tissue, granulation tissue, epithelialisation, amount of exudate and pain level...
August 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27514636/management-of-acute-or-late-hematogenous-infection-after-shoulder-arthroplasty-with-irrigation-d%C3%A3-bridement-and-component-retention
#14
Taylor Dennison, Eduard Alentorn-Geli, Andrew T Assenmacher, John W Sperling, Joaquín Sánchez-Sotelo, Robert H Cofield
BACKGROUND: Irrigation and débridement (I&D) with component retention is an appealing alternative to both patients and surgeons for the management of acute or late hematogenous deep periprosthetic shoulder infection (PSI). However, the success rate and results of I&D are poorly documented. This study reports the outcomes and complications of this treatment strategy for acute and delayed-onset acute hematogenous PSI. METHODS: Between 1980 and 2010, 10 shoulders (9 patients) underwent I&D with component retention for the management on an acute or delayed-onset acute hematogenous PSI at a single institution...
August 8, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27511201/one-stage-revision-with-catheter-infusion-of-intraarticular-antibiotics-successfully-treats-infected-tha
#15
Leo A Whiteside, M E Roy
BACKGROUND: Two-stage revision surgery for infected total hip arthroplasty (THA) is commonly advocated, but substantial morbidity and expense are associated with this technique. In certain cases of infected THA, treatment with one-stage revision surgery and intraarticular infusion of antibiotics may offer a reasonable alternative with the distinct advantage of providing a means of delivering the drug in high concentrations. QUESTIONS/PURPOSES: We describe a protocol for intraarticular delivery of antibiotics to the hip through an indwelling catheter combined with one-stage revision surgery and examine (1) the success as judged by eradication of infection at 1 year when treating chronically infected cemented stems; (2) success in treating late-onset acute infections in well-ingrown cementless stems; and (3) what complications were associated with this approach in a small case series...
August 10, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27506202/guillaine-barre-syndrome-a-rare-complication-of-melioidosis-a-case-report
#16
P W M C S B Wijekoon, K A S Bandara, A Kailainathan, N S Chandrasiri, C T Hapuarachchi
BACKGROUND: Melioidosis caused by Burkholderia pseudomellei is an infection with protean clinical manifestations. Guillain-Barré syndrome [GBS] associated with melioidosis is very rare. CASE PRESENTATION: A 42-year-old woman with diabetes presented with abdominal pain, vomiting and intermittent fever for one month. Six months before presentation she had recurrent skin abscesses. Three months before presentation she had multiple liver abscesses which were aspirated in a local hospital...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27493660/lack-of-association-found-between-helicobacter-pylori-infection-and-diarrhea-predominant-irritable-bowel-syndrome-a-multicenter-retrospective-study
#17
Feng Xiong, Man Xiong, Zonghui Ma, Senxiong Huang, Aimin Li, Side Liu
Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue. Methods. A total of 502 inpatients with Rome III confirmed IBS-D and known H. pylori status from 8 hospitals were enrolled. H. pylori-positive patients, hospitalized in the recent year, were followed up to evaluate the effects of H. pylori eradication on IBS-D clinical course. Results. Of the 502 IBS-D patients, 206 were H...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27473317/knee-arthrodesis-with-a-long-intramedullary-nail-as-limb-salvage-for-complex-periprosthetic-infections
#18
Nima Razii, Ammar M I Abbas, Rahul Kakar, Sanjeev Agarwal, Rhidian Morgan-Jones
BACKGROUND: Periprosthetic infection following total knee arthroplasty is a devastating complication, which is not always satisfactorily resolved by revision surgery. Arthrodesis is a salvage alternative to above-knee amputation or permanent resection arthroplasty. Fixation options include internal compression plating, external fixation, and intramedullary nails. METHODS: We retrospectively reviewed twelve consecutive cases (9 males, 3 females; mean age, 67 years) of knee arthrodesis with a long intramedullary nail, performed at a single institution between 2003 and 2014...
July 29, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27441769/8-low-intensity-pulsed-ultrasound-lipus-treatment-for-the-patient-with-bone-reconstruction-by-the-masquelet-technique-using-ria
#19
Takahiro Niikura, Sang Yang Lee, Takashi Iwakura, Masahiro Kurosaka
BACKGROUND: The Masquelet technique is a relatively new option in the management of bone defects. It consists of 2-stage surgery. At first surgery, a cement spacer is placed to fill the bone defect. After a waiting period of 6-8 weeks, a pseudo-synovial membrane is formed around the cement. The induced membrane is rich in vascularity and osteogenic activity. At second surgery, the cement is replaced with an autologous bone graft and the graft is packed in the membrane. To harvest large quantities of bone graft, the reamer irrigator aspirator (RIA) is utilized...
August 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27414995/lumbar-facet-joint-septic-arthritis-presenting-atypically-as-acute-abdomen-a-case-report-and-review-of-the-literature
#20
Aysha Rajeev, Nameer Choudhry, Mazharuddin Shaikh, Mike Newby
INTRODUCTION: Septic arthritis of the lumbar facet joints is uncommon. The clinical presentation is unusual and patients usually presents with acute back pain or with signs and symptoms mimicking acute abdomen. PRESENTATION OF CASE: A 52year old man was admitted to the surgical ward with acute onset of abdominal pain and a provisional diagnosis of acute pyelonephritis. After the initial inconclusive investigations, magnetic resonance imaging was highly suggestive of lumbar facet joint septic arthritis...
2016: International Journal of Surgery Case Reports
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