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ER stress and pain

H Viisanen, H Chapman, H Wei, M Lasierra Losada, A Koivisto, K E Akerman, A Pertovaara
Methylglyoxal (MG) is a reactive carbonyl compound generated in diabetes mellitus. MG is an established transient receptor potential ankyrin 1 (TRPA1) channel agonist that contributes to TRPA1-mediated diabetic pain hypersensitivity. Here we studied whether exposure to diabetes and thereby to elevated endogenous MG modulates hypersensitivity induced by intradermal MG. Moreover, since diabetes induces endoplasmic reticulum (ER) stress, we compared the role of TRPA1 in diabetes and ER stress by assessing whether tunicamycin-induced ER stress, without diabetes, produces TRPA1-mediated pain hypersensitivity and by assessing whether ER stress and diabetes have similar modulatory effects on MG-induced hypersensitivity...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Jack I Pardo, Vicente R Solà, Andrea A Morales
OBJECTIVE: To evaluate the efficacy of laser photothermal therapy in a group of Chilean women with SUI. MATERIAL AND METHODS: Longitudinal prospective study based on 42 women with mild-to-severe SUI, intervened with non ablative Er:YAG laser, between July 2014 and October 2015, in Santiago, Chile. The therapy efficacy was evaluated through the difference between every patient's scores obtained, before and after treatment, with the International Consultation on Incontinence Questionnaire - Urinary Incontinence Short Form (ICIQ-SF), at a confidence level of 95%...
September 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Arunima Datta, Chandana Aditya, Ashis Mukhopadhyay
Breast cancer impacts on the daily lives of women particularly their physical and emotional health relationships and social life. This paper highlights how women cope with disease and treatment and the strategies they employ to manage their diagnosis alongside daily life. Twenty women were interviewed at different stages in their treatment period: nine women were prior to radiotherapy, eight women after 1 year of chemotherapy, and 10 women after 2 years or more than two of both chemo and radiation therapy...
May 30, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Yan Deng, Somchai Sriwiriyajan, Aman Tedasen, Poonsit Hiransai, Potchanapond Graidist
ETHNOPHARMACOLOGICAL RELEVANCE: Piper nigrum is widely used as a folk medicine including usage for pain relief, fevers, as well as an anti-cancer agent. However the crude extract of piperine free P. nigrum (PFPE), which inhibits breast cancer, and its mechanisms are still being kept secret. This research aims to elucidate the anti-cancer effects of PFPE and its mechanisms. MATERIALS AND METHODS: Anti-cancer effects of PFPE were investigated in N-nitroso-N-methylurea (NMU)-induced mammary tumorigenesis rats and breast cancer cell lines MCF-7 and ZR-75-1...
July 21, 2016: Journal of Ethnopharmacology
Ranu Tripathi, Preeti Singh, Aru Singh, Megha Chagtoo, Sajid Khan, Swasti Tiwari, Gaurav Agarwal, Syed Musthapa Meeran, Madan M Godbole
Women consuming molecular iodine (I2) through seaweeds suffer the least from breast cancers. Zoledronate (Zol) is in clinical use for alleviation of bone pain in cancer patients. Triple negative breast cancers exhibit high mortality due to lack of neoadjuvant chemotherapy. I2 and Zol independently cause weak antiproliferative and apoptotic effect. So far, their combined effects have not been tested. We analyzed the effect of combination of I2 with Zol as a potent adjuvant therapeutic agent for triple negative breast cancer cells (MDA-MBA-231) and in the mice model of breast cancer...
May 2016: Nutrition and Cancer
Alon D Altman, James R Bentley, Paula V Rittenberg, Shawn K Murray
OBJECTIVE: To present the clinicopathologic features of two cases of luteinized thecomas with sclerosing peritonitis (LTSP), characterize the cellular proliferation in the sclerosing peritonitis (SP), and review the literature. METHODS: The clinical, laboratory, and imaging data, operative findings, and pathology materials were reviewed and summarized. Samples of the SP were stained with keratin AE1/AE3, vimentin, CD34, calretinin, smooth muscle actin, ER/PR, CD10 and desmin...
January 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Erica Maffei, Sara Seitun, Andrea I Guaricci, Filippo Cademartiri
Cardiac CT has developed into a robust clinical tool during the past 15 years. Of the fields in which the potential of cardiac CT has raised more interest is chest pain in acute settings. In fact, the possibility to exclude with high reliability obstructive coronary artery disease (CAD) in patients at low-to-intermediate risk is of great interest both from the clinical standpoint and from the management standpoint. Several other modalities, with or without imaging, have been used during the past decades in the settings of new onset chest pain or in acute chest pain for both diagnostic and prognostic assessment of CAD...
2016: British Journal of Radiology
Urška B Ogrinc, Sabina Senčar, Helena Lenasi
BACKGROUND AND OBJECTIVE: Urinary incontinence (UI) is a common disorder that affects women of various ages and impacts all aspects of life. Our aim was to evaluate the non-invasive erbium:yttrium-aluminum-garnet (Er:YAG) laser that exploits its thermal effect and has been used in reconstructive and rejuvenation surgery as a potential treatment strategy for stress UI (SUI) and mixed UI (MUI). STUDY DESIGN/MATERIALS AND METHODS: We included 175 women (aged 49.7 ± 10 years) with newly diagnosed SUI (66% of women) and MUI (34%), respectively...
November 2015: Lasers in Surgery and Medicine
Johan Fernø, Rosa Señarís, Carlos Diéguez, Manuel Tena-Sempere, Miguel López
Initially implicated in the regulation of feeding, orexins/hypocretins are now acknowledged to play a major role in the control of a wide variety of biological processes, such as sleep, energy expenditure, pain, cardiovascular function and neuroendocrine regulation, a feature that makes them one of the most pleiotropic families of hypothalamic neuropeptides. While the orexigenic effect of orexins is well described, their central effects on energy expenditure and particularly on brown adipose tissue (BAT) thermogenesis are not totally unraveled...
December 15, 2015: Molecular and Cellular Endocrinology
Devalingam Mahalingam, Sukeshi Patel, Gerard Nuovo, George Gill, Giovanni Selvaggi, Matt Coffey, Steffan T Nawrocki
BACKGROUND: Activating mutations in RAS are present in the majority of pancreatic cancer cases and represent an ideal therapeutic target. Reolysin is a proprietary formulation of oncolytic reovirus that is currently being evaluated in multiple clinical trials due to its ability to selectively replicate in cells harboring an activated RAS pathway. Here we report for the first time the presence of reovirus replication and induction of endoplasmic reticular (ER) stress in a primary tumor specimen collected from a pancreatic cancer patient receiving intravenous Reolysin and gemcitabine...
2015: BMC Cancer
Bora Inceoglu, Ahmed Bettaieb, Carlos A Trindade da Silva, Kin Sing Stephen Lee, Fawaz G Haj, Bruce D Hammock
Despite intensive effort and resulting gains in understanding the mechanisms underlying neuropathic pain, limited success in therapeutic approaches have been attained. A recently identified, nonchannel, nonneurotransmitter therapeutic target for pain is the enzyme soluble epoxide hydrolase (sEH). The sEH degrades natural analgesic lipid mediators, epoxy fatty acids (EpFAs), therefore its inhibition stabilizes these bioactive mediators. Here we demonstrate the effects of EpFAs on diabetes induced neuropathic pain and define a previously unknown mechanism of pain, regulated by endoplasmic reticulum (ER) stress...
July 21, 2015: Proceedings of the National Academy of Sciences of the United States of America
Enji Zhang, Min-Hee Yi, Nara Shin, Hyunjung Baek, Sena Kim, Eunjee Kim, Kisang Kwon, Sunyeul Lee, Hyun-Woo Kim, Yong Chul Bae, Yonghyun Kim, O-Yu Kwon, Won Hyung Lee, Dong Woon Kim
Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, but its role in neuropathic pain remains unclear. In this study, we examined the ER stress and the unfolded protein response (UPR) activation in a L5 spinal nerve ligation (SNL)-induced rat neuropathic pain model. SNL-induced neuropathic pain was assessed behaviorally using the CatWalk system, and histologically with microglial activation in the dorsal spinal horn. L5 SNL induced BIP upregulation in the neuron of superficial laminae of dorsal spinal horn...
2015: Scientific Reports
Ibrahim M Abbass, Trudy M Krause, Salim S Virani, J Michael Swint, Wenyaw Chan, Luisa Franzini
BACKGROUND: Recent studies cast doubt about the economic efficiency of observation units (OUs). OBJECTIVE: We aimed to reexamine the cost savings of OUs compared with inpatient care. METHODS: Claims for 15,851 patients who were admitted to inpatient or OUs between January 2009 and December 2012 following emergency room (ER) visits for chest pain were retrospectively examined. The two groups were compared for total cost of episode, length of stay (LOS), and utilization rates of diagnostic procedures, including standard exercise and echocardiography stress tests, myocardial perfusion imaging (MPI), coronary computed tomography angiography (CCTA), and computed tomography (CT) chest scans...
March 2015: Managed Care
(no author information available yet)
Among active component U.S. service members in 2014, there were 403 incident episodes of rhabdomyolysis likely due to physical exertion or heat stress ("exertional rhabdomyolysis"). Th e annual incidence rates of exertional rhabdomyolysis increased nearly 50% during 2010–2014. In 2014, the highest incidence rates occurred in service members who were male; younger than 20 years of age; black, non-Hispanic; members of the Marine Corps and Army; recruit trainees; and in combat-specific occupations. Incidence rates were higher among service members with homes of record from the Northeast compared to other U...
March 2015: MSMR
Michael D Briggs, Peter A Bell, Katarzyna A Pirog
Genetic skeletal diseases (GSDs) are an extremely diverse and complex group of rare genetic diseases that primarily affect the development and homeostasis of the osseous skeleton. There are more than 450 unique and well-characterised phenotypes that range in severity from relatively mild to severe and lethal forms. Although individually rare, as a group of related genetic diseases, GSDs have an overall prevalence of at least 1 per 4,000 children. Qualitative defects in cartilage structural proteins result in a broad spectrum of both recessive and dominant GSDs...
June 2015: International Journal of Molecular Medicine
Teruo Hayashi
Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer. Recent research exploring the molecular function of the sigma-1 receptor started unveiling underlying mechanisms of the therapeutic activity of those ligands. Via the molecular chaperone activity, the sigma-1 receptor regulates protein folding/degradation, ER/oxidative stress, and cell survival. The chaperone activity is activated or inhibited by synthetic sigma-1 receptor ligands in an agonist-antagonist manner...
January 2015: Journal of Pharmacological Sciences
Eun Sun Yang, Jin Young Bae, Tae Heon Kim, Yun Sook Kim, Kyoungho Suk, Yong Chul Bae
Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediators induce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little data on the role of the ER stress response in pain mechanisms. In this study, we explored whether the ER stress response is involved in orofacial inflammatory pain by using a complete Freund's adjuvant (CFA)-injected rat model. The thermal pain hypersensitivity increased significantly after CFA injection...
December 2014: Experimental Neurobiology
Sigrid Sudhaus, Sabine Held, Daniela Schoofs, Janina Bültmann, Irina Dück, Oliver T Wolf, Monika I Hasenbring
Recent clinical studies in patients with lower back pain indicate that maladaptive fear-avoidance- and endurance-related pain responses (FAR and ER) have an influence on pain-induced physiological stress levels. The aim of the present study was to follow-up these results under well-controlled laboratory conditions. For this purpose, 30 healthy adults were asked to indicate their usual responses to pain, and were then confronted with an experimental pain stimulus (cold pressor test). Cortisol served as a measure of physiological stress...
February 2015: Psychoneuroendocrinology
Wolter Paans, Maria Müller-Staub
PURPOSE: The purpose of the study is (a) to describe care needs derived from records of patients in Dutch hospitals, and (b) to evaluate whether nurses employed the NANDA-I classification to formulate patients' care needs. METHODS: A stratified cross-sectional random-sampling nursing documentation audit was conducted employing the D-Catch instrument in 10 hospitals comprising 37 wards. FINDINGS: The most prevalent nursing diagnoses were acute pain, nausea, fatigue, and risk for impaired skin integrity...
October 2015: International Journal of Nursing Knowledge
Ana Sofia Carvalho, Helena Ribeiro, Paula Voabil, Deborah Penque, Ole N Jensen, Henrik Molina, Rune Matthiesen
We investigated the molecular effects of glucosamine supplements, a popular and safe alternative to nonsteroidal anti-inflammatory drugs, for decreasing pain, inflammation, and maintaining healthy joints. Numerous studies have reported an array of molecular effects after glucosamine treatment. We questioned whether the differences in the effects observed in previous studies were associated with the focus on a specific subproteome or with the use of specific cell lines or tissues. To address this question, global mass spectrometry- and transcription array-based glucosamine drug profiling was performed on malignant cell lines from different stages of lymphocyte development...
December 2014: Molecular & Cellular Proteomics: MCP
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