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https://www.readbyqxmd.com/read/29684803/early-gastric-cancer-with-diffuse-heterotopic-gastric-glands-and-granular-cell-tumors-mimicking-advanced-gastric-cancer
#1
Yusuke Watanabe, Masato Watanabe, Nobuhiro Suehara, Nami Ishikawa, Tomohiko Shinkawa, Taizo Hosokawa, Hirotada Akiho, Mari Mine, Sadafumi Tamiya, Kazuyoshi Nishihara, Toru Nakano
INTRODUCTION: Heterotopic gastric grands (HGGs) are gastric grands that are observed in the submucosa and are considered to be paracancerous lesions or precursors of gastric cancer (GC). Granular cell tumors (GCTs) are benign neural origin tumors. Gastrointestinal GCTs are rare and gastric GCTs are seldom seen. We report the case of a patient who was diagnosed with early GC with diffuse HGGs affecting the whole stomach and two GCTs mimicking advanced GC. PRESENTATION OF CASE: The patient is a 71-year-old male with epigastric discomfort...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29683892/implication-of-highly-cytotoxic-natural-killer-cells-for-esophageal-squamous-cell-carcinoma-treatment
#2
Kee Siang Lim, Kosaku Mimura, Ley-Fang Kua, Kensuke Shiraishi, Koji Kono
Esophageal squamous cell carcinoma (ESCC) is an aggressive upper gastrointestinal cancer and effective treatments are limited. Previous studies reported that natural killer (NK) cells expanded by coculturing with K562-mb15-41BBL feeder cells, a genetically modified K562 leukemia cell line that expresses membrane-bound interleukin (IL)-15 and 41BBL ligand, were highly proliferative and highly cytotoxic. Here, we investigated the potential of expanded NK cells for ESCC treatment. We analyzed both genetic and surface expression levels of NKG2D ligands (NKG2DLs) in ESCC using publicly available microarray data sets and ESCC cell lines...
April 20, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29683186/morbidity-and-mortality-according-to-age-following-gastrectomy-for-gastric-cancer
#3
S D Nelen, K Bosscha, V E P P Lemmens, H H Hartgrink, R H A Verhoeven, J H W de Wilt
BACKGROUND: This study investigated age-related differences in surgically treated patients with gastric cancer, and aimed to identify factors associated with outcome. METHODS: Data from the Dutch Upper Gastrointestinal Cancer Audit were used. All patients with non-cardia gastric cancer registered between 2011 and 2015 who underwent surgery were selected. Patients were analysed by age group (less than 70 years versus 70 years or more). Multivariable logistic regression was used to assess the influence of clinicopathological factors on morbidity and mortality...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29682717/-use-of-c-response-protein-in-predicting-postoperative-anastomotic-leakage-in-patients-with-rectal-cancer
#4
Zejian Lyu, Deqing Wu, Guanfu Cai, Yuwen Luo, Zifeng Yang, Yanyun Zhai, Chuli Yao, Weixian Hu, Junjiang Wang, Yong Li
OBJECTIVE: To investigate the value and feasibility of C reactive protein (CRP) in predicting postoperative anastomotic leakage in rectal cancer patients with enhanced recovery after surgery (ERAS) for safer implementation of this ERAS. METHODS: A cohort study on serum CRP of 455 rectal cancer patients undergoing laparoscopic radical resection according to the ERAS procedure at Gastrointestinal Unit of General Surgery Department, Guangdong General Hospital from August 2014 to June 2017 was retrospectively carried out...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682715/-effect-of-anastomotic-reinforcing-sutures-on-the-incidence-of-anastomotic-leakage-after-laparoscopic-radical-resection-of-rectal-cancer-a-prospective-randomized-controlled-trial
#5
Yiren He, Zhiqiang Zhu, Shaojun Liu, Liu Liu, Bin Hu, Xiao Wan, Qiang Huang
OBJECTIVE: To investigate the effect of anastomotic reinforcing sutures on the incidence of anastomotic leakage after laparoscopic radical resection of rectal cancer. METHODS: In this study, 300 patients diagnosed with rectal cancer, scheduled to undergo laparoscopic anterior resection at the Department of Gastrointestinal Surgery of Anhui Provincial Hospital, between September 2014 and December 2016, were prospectively enrolled. Patients were randomly assigned to undergo laparoscopic rectal resection with (reinforcing group, n=150) or without (control group, n=150) anastomotic reinforcing sutures...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682369/intrahepatic-cholangiocarcinoma-masquerading-as-acute-fatty-liver-of-pregnancy-a-case-report-and-review-of-the-literature
#6
Ayman Qasrawi, Omar Abughanimeh, Mouhanna Abu Ghanimeh, Simran Arora-Elder, Osama Yousef, Tarek Tamimi
Cholangiocarcinoma (CCA) is an uncommon cancer and accounts only for 3% of all gastrointestinal malignancies. In this report, we present a case of an intrahepatic cholangiocarcinoma masquerading as acute fatty liver of pregnancy (AFLP). A 38-year-old female who is 36-week pregnant presented with a 1-week history of headache, nausea, vomiting, and right upper abdominal pain, along with hepatomegaly. Laboratory investigations were remarkable for mild leukocytosis, hyperbilirubinemia, proteinuria, and elevated transaminases and prothrombin time...
2018: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29682205/ferric-citrate-and-ferric-edta-but-not-ferrous-sulfate-drive-amphiregulin-mediated-activation-of-the-map-kinase-erk-in-gut-epithelial-cancer-cells
#7
Nathalie M Scheers, Dora I A Pereira, Nuno Faria, Jonathan J Powell
Ferric chelates may be used as oral iron supplements or phosphate binders but both ferric citrate and ferric EDTA have been shown to promote tumor burden in murine models of colon cancer. Here we studied their effects on cancer cell growth, at typical supplemental iron levels encountered in the gastrointestinal tract (0.01-0.2 mM). Caco-2 and/or Hutu-80 cells were exposed to these forms of chelated iron or to ferrous sulfate and outcomes were assessed using cell proliferation assays, proteome profiler arrays, western blot, and ELISA...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681865/quercetin-increases-muc2-and-muc5ac-gene-expression-and-secretion-in-intestinal-goblet-cell-like-ls174t-via-plc-pkc%C3%AE-erk1-2-pathway
#8
Simona Damiano, Anna Sasso, Bruna De Felice, Ilaria Di Gregorio, Giuliana La Rosa, Gelsi A Lupoli, Anna Belfiore, Paolo Mondola, Mariarosaria Santillo
The main dietary flavonoid quercetin, is known to preserve the integrity of gastrointestinal barrier and to have anti-inflammatory, anti-cancer, anti-fibrotic, and other beneficial properties. Many of the biological effects of quercetin appear to be associated to the modulation of cell signaling pathways, rather than to its antioxidant activity. In spite of the large number of data available on the molecular and cellular mechanisms by which quercetin exerts its biological effects, including protection of intestinal barrier function, there is a lack of data about the role of this substance on the expression and/or the secretion of mucins released by intestinal goblet cells...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29681016/predicting-symptoms-of-anxiety-and-depression-in-patients-living-with-advanced-cancer-the-differential-roles-of-hope-and-optimism
#9
Ian C Fischer, Larry D Cripe, Kevin L Rand
PURPOSE: Psychological distress is related to poorer functioning and reduced quality of life in patients with advanced cancer and may have untoward influences on treatment decisions. Current research on factors associated with this distress is limited, making targeted interventions to reduce it suboptimal. We examined the relationships between two goal-related expectancies and two of the most common symptoms of psychological distress in patients living with advanced cancer: anxiety and depressive symptoms...
April 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29679368/quality-of-life-of-patients-with-gastrointestinal-cancers-undergoing-chemotherapy
#10
Ilufredo Y Tantoy, Bruce A Cooper, Anand Dhruva, Janine Cataldo, Steven M Paul, Yvette P Conley, Marilyn Hammer, Kord M Kober, Jon D Levine, Christine Miaskowski
PURPOSE: Findings regarding changes in the quality of life (QOL) of patients with gastrointestinal cancers (GI) undergoing chemotherapy (CTX) are inconclusive. Purpose was to evaluate for changes in QOL scores of patients with GI cancers over two cycles of CTX. METHODS: Patients (n = 397) completed disease-specific [i.e., Quality of Life-Scale-Patient Version (QOL-PV)] and generic [12-item Medical Outcomes Study Short Form Survey (SF-12)] measures of QOL a total of six times over two cycles of CTX...
April 21, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29678785/integrin-%C3%AE-v%C3%AE-6-structure-function-and-role-in-health-and-disease
#11
REVIEW
Leeni Koivisto, Jiarui Bi, Lari Häkkinen, Hannu Larjava
Integrins are cell surface receptors that traditionally mediate cell-to-extracellular matrix and cell-to-cell adhesion. They can, however, also bind a large repertoire of other molecules. Integrin αvβ6 is exclusively expressed in epithelial cells where it can, for example, serve as a fibronectin receptor. However, its hallmark function is to activate transforming growth factor-β1 (TGF-β1) to modulate innate immune surveillance in lungs and skin and along the gastrointestinal tract, and to maintain epithelial stem cell quiescence...
April 17, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29677240/uveal-effusion-after-immune-checkpoint-inhibitor-therapy
#12
Merina Thomas, Stephen T Armenti, M Bernadete Ayres, Hakan Demirci
Importance: Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a promising new immunotherapy for solid cancers. The adverse effects typically include inflammation of the skin, endocrine, and gastrointestinal systems. Objective: To describe 3 patients who developed uveal effusion after initiating anti-PD-1 and anti-PD-L1 monoclonal antibody therapy...
April 12, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29677073/outcomes-after-cardiac-transplant-for-wild-type-transthyretin-amyloidosis
#13
Andrew N Rosenbaum, Omar F Abou Ezzeddine, Martha Grogan, Angela Dispenzieri, Sudhir Kushwaha, Alfredo Clavell, Richard C Daly, Brooks S Edwards
BACKGROUND: The true prevalence of heart failure (HF) due to wild type transthyretin amyloidosis (ATTRwt) is likely underestimated. There is a paucity of data with regard to the management of ATTRwt-related advanced HF and the natural history of extracardiac ATTRwt. METHODS: We conducted a retrospective cohort study of patients undergoing cardiac transplant (HTx) for ATTRwt at a single institution. Comprehensive clinical data, including baseline hemodynamic and echocardiographic characteristics, and posttransplant outcomes were obtained...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29675417/developing-a-reliable-mouse-model-for-cancer-therapy-induced-cardiovascular-toxicity-in-cancer-patients-and-survivors
#14
Kyung Ae Ko, Yin Wang, Sivareddy Kotla, Yuka Fujii, Hang Thi Vu, Bhanu P Venkatesulu, Tamlyn N Thomas, Jan L Medina, Young Jin Gi, Megumi Hada, Jane Grande-Allen, Zarana S Patel, Sarah A Milgrom, Sunil Krishnan, Keigi Fujiwara, Jun-Ichi Abe
Background: The high incidence of cardiovascular events in cancer survivors has long been noted, but the mechanistic insights of cardiovascular toxicity of cancer treatments, especially for vessel diseases, remain unclear. It is well known that atherosclerotic plaque formation begins in the area exposed to disturbed blood flow, but the relationship between cancer therapy and disturbed flow in regulating plaque formation has not been well studied. Therefore, we had two goals for this study; (1) Generate an affordable, reliable, and reproducible mouse model to recapitulate the cancer therapy-induced cardiovascular events in cancer survivors, and (2) Establish a mouse model to investigate the interplay between disturbed flow and various cancer therapies in the process of atherosclerotic plaque formation...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29675308/quantifying-optical-properties-with-visible-and-near-infrared-optical-coherence-tomography-to-visualize-esophageal-microwave-ablation-zones
#15
Ryan C Niemeier, Sevde Etoz, Daniel A Gil, Melissa C Skala, Christopher L Brace, Jeremy D Rogers
Microwave ablation is a minimally invasive image guided thermal therapy for cancer that can be adapted to endoscope use in the gastrointestinal (GI) tract. Microwave ablation in the GI tract requires precise control over the ablation zone that could be guided by high resolution imaging with quantitative contrast. Optical coherence tomography (OCT) provides ideal imaging resolution and allows for the quantification of tissue scattering properties to characterize ablated tissue. Visible and near-infrared OCT image analysis demonstrated increased scattering coefficients ( μs ) in ablated versus normal tissues (Vis: 347...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29673791/the-effects-of-polysaccharides-from-auricularia-auricula-huaier-in-adjuvant-anti-gastrointestinal-cancer-therapy-a-systematic-review-and-network-meta-analysis
#16
REVIEW
Yan Ma, Chen Wang, Qi Zhang, Xia Peng, Ying Feng, Xianjun Meng
The aim of this study was to assess the comparative efficacy and safety of polysaccharides from Auricularia auricula (Huaier) for patients with gastrointestinal cancers (GICs) through a systematic review and network meta-analysis. We performed a network meta-analysis to identify evidence from clinical trials. We searched databases for publications up to February 2018. The prespecified primary efficacy outcomes were clinical therapeutic effects, which included the treatment response rate, 0.5-year overall survival rate, 1-year overall survival rate, 2-year overall survival rate, KPS improved rate and AFP decreased rate...
April 16, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29673583/novel-artificial-stool-material-for-external-quality-assurance-eqa-on-a-fecal-immunochemical-test-for-hemoglobin-fit-the-confirmed-utility-of-stable-hemoglobin-and-an-internal-standard-material
#17
Ryota Yasui, Miyu Yamada, Shizuka Takehara, Ikunosuke Sakurabayashi, Katsunori Watanabe
The fecal immunochemical test for hemoglobin (FIT), which detects lower gastrointestinal bleeding, is widely accepted for population-based colorectal cancer (CRC) screening programs. However, the FIT screening process has not been standardized yet, and standardizing the pre-analytical phase and establishing an external quality assurance (EQA) program compliant with ISO requirements is urgently needed. Although there have been various attempts to establish EQA materials suitable for FIT, no materials have yet been reported to have sufficient uniformity and acceptable immunochemical stability of hemoglobin (Hb)...
April 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29673080/systemic-sclerosis-and-malignancy
#18
Gokhan Sargin, Taskin Senturk, Songul Cildag
BACKGROUND: Systemic sclerosis (SSc) has increased risk of morbidity and mortality due to pulmonary fibrosis, pulmonary arterial hypertension, renal crisis, infections and malignancies. Chemical exposure, smoking and cytotoxic drugs increase the malignancy risk in rheumatic diseases including SSc. We aim to evaluate characteristics, identify risk factors and mortality in SSc patients with malignancies. METHODS: One hundred and fifty-three patients with SSc (24 male, 129 female, with mean age of 56...
April 19, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29672847/loss-of-n-wasp-drives-early-progression-in-an-apc-model-of-intestinal-tumourigenesis
#19
Hayley T Morris, Loic Fort, Heather J Spence, Rachana Patel, David F Vincent, James H Park, Scott B Snapper, Francis A Carey, Owen J Sansom, Laura M Machesky
N-WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N-WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic dissemination of breast cancer. Given this role in cancer invasion and universal expression in the gastrointestinal tract, we explored a role for N-WASP in the initiation and progression of colorectal cancer. While deletion of N-wasp is not detectably harmful in the murine intestinal tract, numbers of Paneth cells increased, indicating potential changes in the stem cell niche and migration up the crypt-villus axis was enhanced...
April 19, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29672153/p21-activated-kinase4-in-pancreatic-acini-is-activated-by-gi-hormones-growth-factors-by-novel-signaling-and-is-needed-to-stimulate-secretory-growth-cascades
#20
Irene Ramos-Alvarez, Robert T Jensen
p21-activated kinases(PAKs) are highly conserved serine/threonine protein kinases, which are divided into two groups:Group-I(PAKs1-3) and Group-II(PAKs4-6). In various tissues, Group-II PAKs play important roles in cytoskeletal dynamics, cell growth as well as neoplastic development/progression. However, little is known about Group-II PAKs role in a number of physiological events including their ability to be activated by gastrointestinal(GI) hormones/neurotransmitters/growth-factors(GFs). We used rat pancreatic acini to explore the ability of GI-hormones/neurotransmitters/GFs to activate Group-II-PAKs and the signaling cascades involved...
April 19, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
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