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https://www.readbyqxmd.com/read/29667640/-the-efficiency-of-the-application-of-the-modern-computed-technologies-in-the-clinical-practice-and-the-prospects-for-the-further-use-of-the-biomechanical-3d-models-in-forensic-medicine
#1
I Yu Makarov, A V Svetlakov, A V Sotin, S V Shigeev, A A Gusarov, S A Smirenin, V V Emelin, V B Stragis, V A Fetisov
To-day, the computer-assisted 3D-technologies for the mathematical simulation of the engineering facilities are extensively used for the purpose of technical calculations in all branches of industry and building. The positive experience gained with the application of the 3D-models finds wide application in the joined investigations on the topical problems of the prosthetic and surgical treatment of bones, teeth, joints, cardiac valves, blood vessels, etc. The objective of the present study was the analysis of the positive experience with the involvement of the specialists in the design and practical application of 3D-models for the solution of problems facing the medical prosthetics and the management of various pathological conditions...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29666972/initial-experience-with-a-sipm-based-pet-ct-scanner-influence-of-acquisition-time-on-image-quality
#2
Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir, Andrei Iagaru
BACKGROUND: A newly introduced PET/CT scanner (Discovery Meaningful Insights-DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this study, we investigated the impact of various acquisition times on image quality using this SiPM-based PET/CT. METHODS: We reviewed data from 58 participants with cancer who were scanned using the DMI PET/CT scanner. The administered dosages ranged 295...
April 18, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29666196/whole-genome-sequence-of-an-edible-and-potential-medicinal-fungus-cordyceps-guangdongensis
#3
Chenghua Zhang, Wangqiu Deng, Wenjuan Yan, Taihui Li
Cordyceps guangdongensis is an edible fungus which was approved as a novel food by the Chinese Ministry of Public Health in 2013. It also has a broad prospect of application in pharmaceutical industries, with many medicinal activities. In this study, the whole genome of C. guangdongensis GD15, a single spore isolate from a wild strain, was sequenced and assembled with Illumina and PacBio sequencing technology. The generated genome is 29.05 Mb in size, comprising nine scaffolds with an average GC content of 57...
April 17, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29665084/technology-in-parenteral-nutrition-compounding
#4
REVIEW
Caitlin Curtis
Technology is constantly being used in novel ways, and its use in the practice of medicine is no exception. Examples of this include computer physician order entry, barcode-medication scanning, electronic health records (EHRs), and bedside patient charts, to name a few. Compounding parenteral nutrition has been included in this technological revolution, with improvements such as barcode-assisted medication preparation systems and EHR-to-compounder interfaces. Along with some of these electronic advancements come the inevitable improvements and challenges, which are explored in this article...
April 17, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29664613/advanced-materials-and-devices-for-bioresorbable-electronics
#5
Seung-Kyun Kang, Jahyun Koo, Yoon Kyeung Lee, John A Rogers
Recent advances in materials chemistry establish the foundations for unusual classes of electronic systems, characterized by their ability to fully or partially dissolve, disintegrate, or otherwise physically or chemically decompose in a controlled fashion after some defined period of stable operation. Such types of "transient" technologies may enable consumer gadgets that minimize waste streams associated with disposal, implantable sensors that disappear harmlessly in the body, and hardware-secure platforms that prevent unwanted recovery of sensitive data...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29663619/new-directions-in-health-sciences-libraries-in-china
#6
Zhiyun Xie, Jianjing Zhang
This article briefly describes the services provided by Chinese health science libraries and the factors which influence service provision. Driven by new technologies and national initiatives, the key services delivered by Chinese health libraries in the last 10 years have been research support services (such as research impact assessment, support for data management), evidence-based medicine, systematic reviews, the promotion of health information literacy, and the development of institutional repositories...
April 16, 2018: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/29663183/three-visions-of-doctoring-a-gadamerian-dialogue
#7
Benjamin Chin-Yee, Atara Messinger, L Trevor Young
Medicine in the twenty-first century faces an 'identity crisis,' as it grapples with the emergence of various 'ways of knowing,' from evidence-based and translational medicine, to narrative-based and personalized medicine. While each of these approaches has uniquely contributed to the advancement of patient care, this pluralism is not without tension. Evidence-based medicine is not necessary individualized; personalized medicine may be individualized but is not necessarily person-centered. As novel technologies and big data continue to proliferate today, the focus of medical practice is shifting away from the dialogic encounter between doctor and patient, threatening the loss of humanism that many view as integral to medicine's identity...
April 16, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29662530/are-we-ready-for-routine-precision-medicine-highlights-from-the-milan-summit-on-precision-medicine-milan-italy-8-9-february-2018
#8
Luca Mazzarella
On 8 and 9 February 2018, the IFOM-IEO campus in Milan hosted the Milan summit on Precision Medicine, which gathered clinical and translational research experts from academia, industry and regulatory bodies to discuss the state of the art of precision medicine in Europe. The meeting was pervaded by a generalised feeling of excitement for a field that is perceived to be technologically mature for the transition into clinical routine but still hampered by numerous obstacles of a methodological, ethical, regulatory and possibly cultural nature...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29662451/risk-assessment-and-risk-minimization-in-nanomedicine-a-need-for-predictive-alternative-and-3rs-strategies
#9
REVIEW
Lisa Accomasso, Caterina Cristallini, Claudia Giachino
The use of nanomaterials in medicine has grown very rapidly, leading to a concern about possible health risks. Surely, the application of nanotechnology in medicine has many significant potentialities as it can improve human health in at least three different ways: by contributing to early disease diagnosis, improved treatment outcomes and containment of health care costs. However, toxicology or safety assessment is an integral part of any new medical technology and the nanotechnologies are no exception. The principle aim of nanosafety studies in this frame is to enable safer design of nanomedicines...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29662316/metformin-inhibits-proliferation-and-cytotoxicity-and-induces-apoptosis-via-ampk-pathway-in-cd19-chimeric-antigen-receptor-modified-t-cells
#10
Qian Mu, Miao Jiang, Yuzhu Zhang, Fei Wu, Hui Li, Wen Zhang, Fang Wang, Jiang Liu, Liang Li, Dongshan Wang, Wenjuan Wang, Shiwu Li, Haibo Song, Dongqi Tang
Background: CD19-chimericantigen receptor (CAR) modified T cells (CD19-CAR T cells) have been well documented to possess potent anti-tumor properties against CD19-expressingleukemia cells. As a traditional medicine, metformin has been widely used to treat type II diabetes mellitus and more recently has become a candidate for the treatment of cancer. However, no report has revealed the direct effect of metformin on CD19-CAR T cell biological function and its underling mechanisms. Purpose: The purpose of this research was to explore the effect of metformin on CD19-CAR T cell biological function and the mechanisms involved...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29661107/implementation-of-health-information-exchange-at-the-pima-county-adult-detention-complex-lessons-learned
#11
Alyssa Hinchman, Sara Hodges, James Backus, Terri Warholak
Successful transition of patients between health care entities is difficult. Historically, the process of transitioning individuals through the corrections system with regard to health care was made even more challenging by the limitation of paper records. Recently, the advent of electronic medical records has improved health care nationwide. The use of health information exchange (HIE) systems in areas such as emergency medicine has also impacted patient outcomes. To date, this technology has not been used in the corrections system...
April 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29661055/messenger-rna-delivery-for-tissue-engineering-and-regenerative-medicine-applications
#12
Siddharth Patel, Avathamsa Athirasala, Paula Dos Passos Menezes, Narayanan Ashwanikumar, Ting Zou, Gaurav Sahay, Luiz Bertassoni
The ability to control cellular processes and precisely direct cellular reprogramming has revolutionized regenerative medicine. Recent advances in in vitro transcribed (IVT) mRNA technology with chemical modifications have led to development of methods that control spatio-temporal gene expression. Additionally, there is a current thrust towards the development of safe, integration-free approaches to gene therapy for translational purposes. In this review, we describe strategies of synthetic IVT mRNA modifications and non-viral technologies for intracellular delivery...
April 17, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29660494/accurate-filtering-of-privacy-sensitive-information-in-raw-genomic-data
#13
Jérémie Decouchant, Maria Fernandes, Marcus Völp, Francisco M Couto, Paulo Esteves-Veríssimo
Sequencing thousands of human genomes has enabled breakthroughs in many areas, among them precision medicine, the study of rare diseases, and forensics. However, mass collection of such sensitive data entails enormous risks if not protected to the highest standards. In this article, we follow the position and argue that post-alignment privacy is not enough and that data should be automatically protected as early as possible in the genomics workflow, ideally immediately after the data is produced. We show that a previous approach for filtering short reads cannot extend to long reads and present a novel filtering approach that classifies raw genomic data (i...
April 13, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29660210/anions-reversibly-responsive-luminescent-tb-iii-nanocellulose-complex-hydrogels-for-latent-fingerprint-detection-and-encryption
#14
Jun Hai, Tianrong Li, Junxia Su, Wensheng Liu, Yanmin Ju, Baodui Wang, Yanglong Hou
Fingerprint fluorescence imaging has become one of the most prominent technologies in the field of forensic medicine, but it seldom considers the security protection of detection information, which is of great importance in modern society. Here we demonstrate that ClO-/SCN- reversibly responsive luminescent Tb(III) carboxymethyl-cellulose (CMC) complex-binding aptamer hydrogels can be used to realize selective detection, protection, and storage of fingerprint information. The imaging information of the fingerprint can be quenched and recovered by using ClO-/SCN- regulation, respectively, resulting in reversible on/off conversion of the luminescent signals in the process of encryption and decryption of multiple information...
April 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29659566/biocuration-distilling-data-into-knowledge
#15
(no author information available yet)
Data, including information generated from them by processing and analysis, are an asset with measurable value. The assets that biological research funding produces are the data generated, the information derived from these data, and, ultimately, the discoveries and knowledge these lead to. From the time when Henry Oldenburg published the first scientific journal in 1665 (Proceedings of the Royal Society) to the founding of the United States National Library of Medicine in 1879 to the present, there has been a sustained drive to improve how researchers can record and discover what is known...
April 16, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29658474/-prospects-for-applications-in-human-health-of-nanopore-based-sequencing
#16
Christophe Audebert, David Hot, Ségolène Caboche
High throughput sequencing has opened up new clinical opportunities moving towards a medicine of precision. Oncology, infectious diseases or human genomics, many applications have been developed in recent years. The introduction of a third generation of nanopore-based sequencing technology, addressing some of the weaknesses of the previous generation, heralds a new revolution. Portability, real time, long reads and marginal investment costs, these promising new technologies point to a new shift of paradigm...
April 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29657856/collaborative-academic-medical-product-development-an-8-year-review-of-commercialization-outcomes-at-the-institute-of-translational-health-sciences
#17
Lynn M Rose, Fiona Wills, Connie Bourassa-Shaw, Terri L Butler, Jeanette Griscavage Ennis, Kim Emmons, Patrick Shelby, Meher Antia, Kim Folger Bruce
Introduction: The Institute of Translational Health Sciences (ITHS), a Clinical and Translational Science Award (CTSA)-funded program at the University of Washington (UW), established the Drug and Device Advisory Committee (DDAC) to provide product-specific scientific and regulatory mentoring to investigators seeking to translate their discoveries into medical products. An 8-year retrospective analysis was undertaken to evaluate the impact of the DDAC programs on commercialization metrics...
August 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29656795/single-cell-microgels-technology-challenges-and-applications
#18
REVIEW
Tom Kamperman, Marcel Karperien, Séverine Le Gac, Jeroen Leijten
Single-cell-laden microgels effectively act as the engineered counterpart of the smallest living building block of life: a cell within its pericellular matrix. Recent breakthroughs have enabled the encapsulation of single cells in sub-100-μm microgels to provide physiologically relevant microniches with minimal mass transport limitations and favorable pharmacokinetic properties. Single-cell-laden microgels offer additional unprecedented advantages, including facile manipulation, culture, and analysis of individual cell within 3D microenvironments...
April 12, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29655527/the-smiling-scan-technique-facially-driven-guided-surgery-and-prosthetics
#19
Alessandro Pozzi, Lorenzo Arcuri, Peter K Moy
PURPOSE: To introduce a proof of concept technique and new integrated workflow to optimize the functional and esthetic outcome of the implant-supported restorations by means of a 3-dimensional (3D) facially-driven, digital assisted treatment plan. METHODS: The Smiling Scan technique permits the creation of a virtual dental patient (VDP) showing a broad smile under static conditions. The patient is exposed to a cone beam computed tomography scan (CBCT), displaying a broad smile for the duration of the examination...
April 11, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29653249/directing-neuronal-cell-fate-in-vitro-achievements-and-challenges
#20
REVIEW
R J M Riemens, D L van den Hove, M Esteller, R Delgado-Morales
Human pluripotent stem cell (PSC) technology and direct somatic cell reprogramming have opened up a promising new avenue in the field of neuroscience. These recent advances allow researchers to obtain virtually any cell type found in the human brain, making it possible to produce and study functional neurons in laboratory conditions for both scientific and medical purposes. Although distinct approaches have shown to be successful in directing neuronal cell fate in vitro, their refinement and optimization, as well as the search for alternative approaches, remains necessary to help realize the full potential of the eventually derived neuronal populations...
April 10, 2018: Progress in Neurobiology
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