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https://www.readbyqxmd.com/read/29046028/-aria-2016-executive-summary-integrated-care-pathways-for-predictive-medicine-throughout-the-life-cycle-in-argentina
#1
Juan Carlos Ivancevich, Hugo Neffen, Mario E Zernotti, Estrella Asayag, Ariel Blua, Alberto Cicerán, Edgardo J Jares, Alberto J Lavrut, Jorge F Máspero, Ioana Agache, Claus Bachert, Anna Bedbrook, Giorgio W Canonica, Thomas B Casale, Álvaro A Cruz, Wytske J Fokkens, Peter W Hellings, Boleslaw Samolinski, Jean Bousquet
The ARIA initiative was started during a World Health Organization workshop in 1999. The initial goals were to propose a new classification for allergic rhinitis, to promote the concept of multi-morbidity in asthma and rhinitis and to develop guidelines with stakeholders for world-wide use. ARIA is now focused on the implementation of emerging technologies for individualized and predictive medicine. MASK: MACVIA-Aria Sentinel Network uses mobile technology to develop care pathways that enable management by a multidisciplinary group or by patients themselves...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045276/impact-of-required-versus-self-directed-use-of-virtual-patient-cases-on-clerkship-performance-a-mixed-methods-study
#2
Sarang Kim, Laura R Willett, Wilbur J Pan, Joyce Afran, John A Walker, Judy A Shea
PURPOSE: To explore how students use and benefit from virtual patient cases (VPCs). METHOD: In academic years 2013-2014 and 2014-2015, cohorts of students in pediatrics (Peds), family medicine (FM), and internal medicine (IM) clerkships were allocated to either core required use (CRU) or self-directed use (SU) of MedU VPCs. Outcomes included number and time of case review, student perception of learning from VPCs, National Board of Medical Examiners (NBME) subject examination scores, and summative clinical ratings for medical knowledge and differential diagnoses/problem solving...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29044404/a-new-cordycepin-producing-caterpillar-fungus-ophiocordyceps-xuefengensis-with-artificial-infection-to-the-host-cultivation-of-mycelia-and-stromata
#3
Jian Jin, Can Zhong, You Qin, Yuan Cai, Lanping Zhen, Bingbing Shen, Lin Chen, Dan Wan, Yuhui Qin, Shuihan Zhang
Caterpillar fungi have numerous pharmacological and therapeutic applications in traditional medicine, due to a variety of active chemical constituents, such as cordycepin and adenosine. It is imperative to discover new resource for artificial cultivation and biometabolite production since the traditional natural species are endangered. In this study, a new strain HACM 001 was isolated and identified as Ophiocordyceps xuefengensis by rDNA-ITS sequencing. This strain showed the potential of artificial infection to caterpillar larvae leading to mummification, as well as fermentation mycelia in liquid culture and cultivation stromata in solid medium...
November 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29043986/potential-of-big-data-analytics-in-the-french-in-vitro-diagnostics-market
#4
Nicolas Dubois, Nicolas Garnier, Christophe Meune
The new paradigm of the big data raises many expectations, particularly in the field of health. Curiously, even though medical biology laboratories generate a great amount of data, the opportunities offered by this new field are poorly documented. For better understanding the clinical context of chronical disease follow-up, for leveraging preventive and/or personalized medicine, the contribution of big data analytics seems very promising. It is within this framework that we have explored to use data of a Breton group of laboratories of medical biology to analyze the possible contributions of their exploitation in the improvement of the clinical practices and to anticipate the evolution of pathologies for the benefit of patients...
October 18, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29043949/arthroscopic-surgery-for-knee-osteoarthritis-impact-of-health-technology-assessment-in-germany
#5
Naomi Fujita-Rohwerder, Alric Rüther, Stefan Sauerland
OBJECTIVES: This study aims to describe how a negative reimbursement decision-based on the health technology assessment (HTA) report of a nondrug intervention-affects healthcare providers in Germany. METHODS: Knee arthroscopy was chosen as an example, because as of April 2016 this procedure is no longer reimbursed for osteoarthritis, but is still covered for other indications, including meniscal lesions. The exclusion followed an HTA report prepared by the Institute for Quality and Efficiency in Health Care (IQWiG)...
October 18, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29043857/magnetic-carbon-nanotubes-preparation-physical-properties-and-applications-in-biomedicine
#6
Mehrdad Samadishadlou, Masoud Farshbaf, Nasim Annabi, Taras Kavetskyy, Rovshan Khalilov, Siamak Saghfi, Abolfazl Akbarzadeh, Sepideh Mousavi
Magnetic carbon nanotubes (MCNTs) have been widely studied for their potential applications in medicine, diagnosis, cell biology, analytical chemistry, and environmental technology. Introduction of MCNTs paved the way for the emergence of new approaches in nanobiotechnology and biomedicine as a result of their multifarious properties embedded within either the carbon nanotubes (CNTs) or magnetic parts. Numerous preparation techniques exists for functionalizing CNTs with magnetic nanoparticles, and these versatile strategies lay the ground for the generation of novel and versatile systems which are applicable to many industries and biological areas...
October 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29043570/towards-precision-nephrology-the-opportunities-and-challenges-of-genomic-medicine
#7
REVIEW
Jordan G Nestor, Emily E Groopman, Ali G Gharavi
The expansion of genomic medicine is furthering our understanding of many human diseases. This is well illustrated in the field of nephrology, through the characterization, discovery, and growing insight into various renal diseases through use of Next Generation Sequencing (NGS) technologies. This review will provide an overview of the diagnostic opportunities of using genetic testing in the clinical setting by describing notable discoveries regarding inherited forms of renal disease that have advanced the field and by highlighting some of the potential benefits of establishing a molecular diagnosis in a clinical practice...
October 17, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29043540/between-quality-of-life-and-hope-attitudes-and-beliefs-of-muslim-women-toward-withholding-and-withdrawing-life-sustaining-treatments
#8
REVIEW
Chaïma Ahaddour, Stef Van den Branden, Bert Broeckaert
The technological advances in medicine, including prolongation of life, have constituted several dilemmas at the end of life. In the context of the Belgian debates on end-of-life care, the views of Muslim women remain understudied. The aim of this article is fourfold. First, we seek to describe the beliefs and attitudes of middle-aged and elderly Moroccan Muslim women toward withholding and withdrawing life-sustaining treatments. Second, we aim to identify whether differences are observable among middle-aged and elderly women's attitudes toward withholding and withdrawing life-sustaining treatments...
October 17, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29043011/debates-in-allergy-medicine-allergy-skin-testing-cannot-be-replaced-by-molecular-diagnosis-in-the-near-future
#9
Désirée Larenas-Linnemann, Jorge A Luna-Pech, Ralph Mösges
Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has good reproducibility, is easily quantified, and allows analyzing multiple allergens simultaneously. Potent extracts and a proficient tester improve its accuracy. Molecular-based allergy diagnostics (MA-Dx) quantifies allergenic components obtained either from purification of natural sources or recombinant technology to identify the patient's reactivity to those specific allergenic protein components...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29042823/digital-health-technology-for-use-in-patients-with-serious-mental-illness-a-systematic-review-of-the-literature
#10
REVIEW
Sonal Batra, Ross A Baker, Tao Wang, Felicia Forma, Faith DiBiasi, Timothy Peters-Strickland
BACKGROUND: As the capabilities and reach of technology have expanded, there is an accompanying proliferation of digital technologies developed for use in the care of patients with mental illness. The objective of this review was to systematically search published literature to identify currently available health technologies and their intended uses for patients with serious mental illness. MATERIALS AND METHODS: The Medline, Embase, and BIOSIS Previews electronic databases were searched to identify peer-reviewed English language articles that reported the use of digital, mobile, and other advanced technology in patients with schizophrenia/schizoaffective disorder, bipolar disorder, and major depressive disorder...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29041693/development-of-a-fiber-optic-gamma-endoscope-to-measure-both-optical-and-gamma-images-in-a-confined-space
#11
Mingeon Kim, Wook Jae Yoo, Bongsoo Lee
In nuclear medicine, obtaining information on the exact location, size, and dose of radiopharmaceuticals distributed on lesions is critically important. Therefore, we have fabricated a novel fiber-optic gamma endoscope (FOGE) to measure the shape and size of the radioisotope as well as the gamma-ray distribution simultaneously. To evaluate the performance of the novel FOGE, we obtained optical images and gamma images by using a USAF 1951 target and radioisotope sources, respectively. The experimental results demonstrated that the FOGE could be utilized to obtain both the location and the distribution of the radioactive isotope that emitted gamma-rays...
August 21, 2017: Optics Express
https://www.readbyqxmd.com/read/29040783/patient-exposure-from-nuclear-medicine-in-france-national-follow-up-and-influence-of-the-technology-through-diagnostic-reference-levels-data-analysis
#12
Patrice Roch, David Celier, Cécile Dessaud, Cécile Etard
The Nuclear Safety and Radiation Protection French Institute (IRSN) presents its latest assessment from up-to-date diagnostic reference levels (DRL) national data in nuclear medicine (NM). NM departments annually send data to IRSN to estimate the representativeness of current DRLs. Complementary analyses of the data have been performed to evaluate the influence of equipment evolution on practice and patient radiation exposure. Based on data from almost 90% of the French NM departments, some DRL update are proposed...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040418/translational-medicine-in-the-age-of-big-data
#13
Nicholas P Tatonetti
The ability to collect, store and analyze massive amounts of molecular and clinical data is fundamentally transforming the scientific method and its application in translational medicine. Collecting observations has always been a prerequisite for discovery, and great leaps in scientific understanding are accompanied by an expansion of this ability. Particle physics, astronomy and climate science, for example, have all greatly benefited from the development of new technologies enabling the collection of larger and more diverse data...
October 12, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29040395/human-genome-sequencing-at-the-population-scale-a-primer-on-high-throughput-dna-sequencing-and-analysis
#14
Rachel L Goldfeder, Dennis P Wall, Muin J Khoury, John P A Ioannidis, Euan A Ashley
Most human diseases have underlying genetic causes. To better understand the impact of genes on disease and its implications for medicine and public health, researchers have pursued methods for determining the sequences of individual genes, then all genes, and now complete human genomes. Massively parallel high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then computationally reordered and analyzed, enables fast and affordable sequencing of full human genomes. As the price of sequencing continues to decline, more and more individuals are having their genomes sequenced...
October 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29039548/-corrigendum-farnesoid-x-receptor-deletion-improves-cardiac-function-structure-and-remodeling-following-myocardial-infarction-in-mice
#15
Jianshu Gao, Xiaoqiang Liu, Bingjian Wang, Haiyan Xu, Qiang Xia, Tianfei Lu, Fang Wang
Following the publication of this article, an interested reader drew to our attention that we had incorrectly reported (in the Materials and methods section, 'Western blot analysis', on p. 674) that the anti-farnesoid X receptor (FXR) antibody of Cell Signalling Technology, Inc., cat. no. #12295, had been used in this study to probe for FXR. In fact, the antibodies used in the above-mentioned study were a gift from the group of Dr Xin-Liang Ma at Thomas Jefferson University (Philadelphia, PA, USA), as referenced in the following article: [Pul J, Yuan A, Shan P, Gao E, Wang X, Wang Y, Lau WB, Koch W, Xin-Ma XL and He B: Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury...
October 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038743/mature-induced-pluripotent-stem-cell-derived-human-podocytes-reconstitute-kidney-glomerular-capillary-wall-function-on-a-chip
#16
Samira Musah, Akiko Mammoto, Thomas C Ferrante, Sauveur S F Jeanty, Mariko Hirano-Kobayashi, Tadanori Mammoto, Kristen Roberts, Seyoon Chung, Richard Novak, Miles Ingram, Tohid Fatanat-Didar, Sandeep Koshy, James C Weaver, George M Church, Donald E Ingber
An in vitro model of the human kidney glomerulus - the major site of blood filtration - could facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a-chip technology has been used to model the human proximal tubule, yet a kidney-glomerulus-on-a-chip has not been possible because of the lack of functional human podocytes - the cells that regulate selective permeability in the glomerulus. Here, we demonstrate an efficient (> 90%) and chemically defined method for directing the differentiation of human induced pluripotent stem (hiPS) cells into podocytes that express markers of the mature phenotype (nephrin+, WT1+, podocin+, Pax2-) and that exhibit primary and secondary foot processes...
2017: Nature biomedical engineering
https://www.readbyqxmd.com/read/29037280/screening-of-chemical-dyes-in-traditional-chinese-medicine-by-hptlc-ms
#17
Fengyan He, Yi He, Xiaowei Zheng, Ruizhong Wang, Jing Lu, Zhong Dai, Shuangcheng Ma
It has been uncovered that chemical dyes are illegally used in traditional Chinese medicines to brighten colorand cover up inferiority, which threaten the safety of patients. In the present study, an HPTLC-MS method was developed for the effective screening of 11 chemical dyes (Sudan I, II, III, and IV; 808 Scarlet; Sudan Red 7B; malachite green; Basic Orange 2; auramine; Orange II; and erythrosine) in traditional Chinese medicine (TCM) raw materials and Chinese patent medicines. Firstly, unwashed HPTLC plates were chosen by comparing the background signals of the TLC plates used directly and prewashed with analytical grade and HPLC grade solvents...
October 17, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29036509/medication-usage-change-in-older-people-65-in-england-over-20-years-findings-from-cfas-i-and-cfas-ii
#18
L Gao, Ian Maidment, Fiona E Matthews, Louise Robinson, Carol Brayne
Background: medical practice has changed over the last decades reflecting the ageing population, when multi-morbidity requiring multiple medications is more common. Objective: describe and quantify self-reported medicine use including both prescription and over the counter medicines in two comparable population-based studies of older people (65+) in England and to assess the nature and scale of polypharmacy. Methods: data used were from two separate population-based studies; the Cognitive Function Ageing Study I and II...
September 26, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29036294/realityconvert-a-tool-for-preparing-3d-models-of-biochemical-structures-for-augmented-and-virtual-reality
#19
Alexandre Borrel, Denis Fourches
Motivation: There is a growing interest for the broad use of Augmented Reality (AR) and Virtual Reality (VR) in the fields of bioinformatics and cheminformatics to visualize complex biological and chemical structures. AR and VR technologies allow for stunning and immersive experiences, offering untapped opportunities for both research and education purposes. However, preparing 3D models ready to use for AR and VR is time-consuming and requires a technical expertise that severely limits the development of new contents of potential interest for structural biologists, medicinal chemists, molecular modellers and teachers...
August 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29035510/crispri-and-crispra-screens-in-mammalian-cells-for-precision-biology-and-medicine
#20
Martin Kampmann
Next-generation DNA sequencing technologies have led to a massive accumulation of genomic and transcriptomic data from patients and healthy individuals. The major challenge ahead is to understand the functional significance of the elements of the human genome and transcriptome, and implications for diagnosis and treatment. Genetic screens in mammalian cells are a powerful approach to systematically elucidate gene function in health and disease states. In particular, recently developed CRISPR/Cas9-based screening approaches have enormous potential to uncover mechanisms and therapeutic strategies for human diseases...
October 16, 2017: ACS Chemical Biology
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