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https://www.readbyqxmd.com/read/29777744/omalizumab-can-inhibit-respiratory-reaction-during-aspirin-desensitization
#1
David M Lang, Mark A Aronica, Elizabeth S Maierson, Xiao-Feng Wang, Dorothy C Vasas, Stanley L Hazen
BACKGROUND: Aspirin desensitization has been associated with benefit in management of aspirin exacerbated respiratory disease (AERD). An intervention that would encourage aspirin desensitization to be performed more frequently has substantial potential for improving outcomes and quality of life in patients with AERD. OBJECTIVE: We investigated whether omalizumab administration would be associated with attenuation of aspirin-provoked bronchospasm in patients with AERD undergoing aspirin desensitization...
May 16, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29771223/enabling-physicians-to-lead-canada-s-leads-framework
#2
Graham Dickson, John Van Aerde
Purpose The purpose of this paper is to provide a case study demonstrating that LEADS in a Caring Environment Capabilities Framework in Canada can assist physicians to be partners in leading health reform. Design/methodology/approach A descriptive case-based approach was followed, relying on existing documents, research papers and peer-reviewed articles, to substantiate the effect of LEADS on physician leadership in Canada. Findings The Canadian LEADS framework enables physicians to lead by providing them with access to best practices of leadership, acting as an antidote to fragmented leadership practice, setting standards for development and accountability and providing opportunities for efficient and effective system-wide leadership development and change...
May 8, 2018: Leadership in Health Services
https://www.readbyqxmd.com/read/29764400/low-cost-hpv-testing-and-the-prevalence-of-cervical-infection-in-asymptomatic-populations-in-guatemala
#3
Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales, Victor Argueta, Andert Rosingh, Femke J H B van Aerde-van Nunen, Griselda Lopez, Herbert M Pinedo, Mark Schiffman, Michael Dean, Roberto Orozco
BACKGROUND: A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determine the most prevalent HPV types and the distribution of HPV infections in over 1795 cancer-free women in Guatemala undergoing primary screening for cervical cancer by cytology...
May 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29682983/long-term-clinical-outcomes-of-aspirin-desensitization-with-continuous-daily-aspirin-therapy-in-aspirin-exacerbated-respiratory-disease
#4
Kristen M Walters, Jeremy D Waldram, Katharine M Woessner, Andrew A White
Background Aspirin-exacerbated respiratory disease (AERD), also known as Samter's triad or aspirin (ASA)-intolerant asthma, affects 7% of asthmatics and has a higher prevalence in those with chronic rhinosinusitis and concomitant nasal polyposis. ASA desensitization with daily ASA therapy is a uniquely beneficial treatment for this disease entity and has been shown to have a significant impact on symptom scores, polyp disease, and need for systemic corticosteroids. However, no long-term studies have demonstrated whether or not ASA therapy remains safe and beneficial for these patients beyond 5-10 years...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29676185/blood-eosinophil-and-basophil-values-before-and-after-surgery-for-eosinophilic-type-sinonasal-polyps
#5
Giuseppe Brescia, Daniela Parrino, Claudia Zanotti, Giulia Tealdo, Umberto Barion, Paolo Sfriso, Gino Marioni
Background Blood eosinophil and basophil levels have recently been considered for the purpose of endotyping chronic rhinosinusitis with nasal polyps (CRSwNP). Histologically, eosinophilic-type CRSwNPs have been associated with high recurrence rates after treatment. Objective The present study was the first to compare blood eosinophil and basophil counts in eosinophilic-type CRSwNP patients before and after endoscopic sinus surgery. Methods The study concerned 79 consecutive patients with histologically confirmed eosinophilic-type CRSwNP treated with endoscopic sinus surgery...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29663427/surfactant-protein-d-alleviates-eosinophil-mediated-airway-inflammation-and-remodeling-in-patients-with-aspirin-exacerbated-respiratory-disease
#6
Youngwoo Choi, Dong-Hyun Lee, Trinh Hoang Kim Tu, Ga-Young Ban, Hanki Park, Yoo Seob Shin, Seung-Hyun Kim, Hae-Sim Park
BACKGROUND: Surfactant protein D (SPD) is a member of the collectin family that lines the airway epithelial cells with host defense. However, the role of SPD in the pathogenesis of aspirin-exacerbated respiratory disease (AERD) is still unclear. METHODS: The serum SPD level was measured in patients with AERD (n=336), those with aspirin-tolerant asthma (ATA, n=442), and healthy controls (HC, n=104). Polymorphisms of SFTPD in the study subjects were analyzed. The effect of LTE4 on SPD production through eosinophil infiltration was investigated in BALB/c mice...
April 16, 2018: Allergy
https://www.readbyqxmd.com/read/29653235/factors-correlated-with-repeated-aspirin-dosing-during-aspirin-desensitization
#7
Charles F Schuler, James L Baldwin, Alan P Baptist
BACKGROUND: Aspirin desensitization is an appropriate procedure for many patients with aspirin-exacerbated respiratory disease (AERD). Patients can require aspirin re-dosing, which prolongs the desensitization process. The frequency of this is not widely reported, nor is it known which patients will require multiple re-dosing. OBJECTIVE: To determine the frequency of and factors associated with repeat aspirin re-dosing during desensitization. METHODS: Charts of aspirin desensitization procedures from 2011-2016 at the University of Michigan Allergy/Immunology Clinic were reviewed...
April 10, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29534838/cortactin-expression-in-nasal-polyps-of-aspirin-exacerbated-respiratory-disease-aerd-patients
#8
Giuseppe Brescia, Daniela Parrino, Lorenzo Nicolè, Claudia Zanotti, Cristiano Lanza, Umberto Barion, Filippo Marino, Gino Marioni
PURPOSE: The term aspirin-exacerbated respiratory disease (AERD) refers to a combination of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and acute respiratory tract reactions to nonsteroidal anti-inflammatory drugs. AERD has now been included among the CRSwNP endotypes, and is considered one of the most aggressive in terms of disease recurrence. Cortactin is a multi-domain protein with a part in several cellular mechanisms involving actin assembly and cytoskeleton arrangement...
May 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29518425/leukotriene-e-4-induces-airflow-obstruction-and-mast-cell-activation-via-the-cyslt-1-receptor
#9
Nikolaos Lazarinis, Johan Bood, Cristina Gomez, Johan Kolmert, Ann-Sofie Lantz, Pär Gyllfors, Andy Davis, Craig E Wheelock, Sven-Erik Dahlén, Barbro Dahlén
BACKGROUND: Leukotriene E4 (LTE4 ) is the final active metabolite among the cysteinyl leukotrienes (CysLTs). Animal studies have identified a distinct LTE4 receptor, suggesting that current CysLT1 receptor antagonists may provide incomplete inhibition of CysLT responses. OBJECTIVE: We tested this hypothesis by assessing the influence of the CysLT1 antagonist montelukast on responses induced by inhalation of LTE4 in asthmatic subjects. METHODS: Fourteen subjects with mild intermittent asthma and two subjects with aspirin exacerbated respiratory disease (AERD) received montelukast 20 mg bid and placebo for 5-7 days in a randomized, double blind, crossover study (NCT01841164)...
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29432042/relationship-between-upper-airway-diseases-exhaled-nitric-oxide-and-bronchial-hyperresponsiveness-to-methacholine
#10
Marina Lluncor, Pilar Barranco, Emerson-Daniel Amaya, Javier Domínguez-Ortega, Valentín López-Carrasco, Isabel Coman, Santiago Quirce
OBJECTIVE: The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. The aim of this study was to determine the relationship between upper airway diseases and bronchial hyperresponsiveness (BHR), as well as their association with the fractional concentration of exhaled nitric oxide (FeNO) and atopy in patients with persistent symptoms suggestive of asthma requiring methacholine challenge testing (MCT) to confirm asthma diagnosis...
February 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29412095/return-on-investment-in-healthcare-leadership-development-programs
#11
Maya M Jeyaraman, Sheikh Muhammad Zeeshan Qadar, Aleksandra Wierzbowski, Farnaz Farshidfar, Justin Lys, Graham Dickson, Kelly Grimes, Leah A Phillips, Jonathan I Mitchell, John Van Aerde, Dave Johnson, Frank Krupka, Ryan Zarychanski, Ahmed M Abou-Setta
Purpose Strong leadership has been shown to foster change, including loyalty, improved performance and decreased error rates, but there is a dearth of evidence on effectiveness of leadership development programs. To ensure a return on the huge investments made, evidence-based approaches are needed to assess the impact of leadership on health-care establishments. As a part of a pan-Canadian initiative to design an effective evaluative instrument, the purpose of this paper was to identify and summarize evidence on health-care outcomes/return on investment (ROI) indicators and metrics associated with leadership quality, leadership development programs and existing evaluative instruments...
February 5, 2018: Leadership in Health Services
https://www.readbyqxmd.com/read/29341466/effects-of-intravenous-home-dobutamine-in-palliative-end-stage-heart-failure-on-quality-of-life-heart-failure-hospitalization-and-cost-expenditure
#12
Pieter Martens, Jan Vercammen, Wendy Ceyssens, Linda Jacobs, Evert Luwel, Herwig Van Aerde, Peter Potargent, Monique Renaers, Matthias Dupont, Wilfried Mullens
AIMS: In patients with palliative end-stage heart failure, interventions that could provide symptomatic relief and prevent hospital admissions are important. Ambulatory continuous intravenous inotropes have been advocated by guidelines for such a purpose. We sought to determine the effect of intravenous dobutamine on symptomatic status, hospital stay, mortality, and cost expenditure. METHODS AND RESULTS: All consecutive end-stage heart failure patients not amenable for advanced therapies and discharged with continuous intravenous home dobutamine from a single tertiary centre between April 2011 and January 2017 were retrospectively analysed...
January 17, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29336282/role-of-group-2-innate-lymphocytes-in-aspirin-exacerbated-respiratory-disease-pathogenesis
#13
Andrew A White, Taylor A Doherty
Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic nasal polyps, asthma, and airway reactions upon cyclooxygenase (COX) 1 inhibition. AERD is present in up to 7% of adult patients with asthma and the underlying pathogenesis remains largely elusive but prostaglandin D2, cysteinyl leukotrienes, mast cells, and type 2 cytokines are thought to contribute. A wealth of studies have recently implicated group 2 innate lymphoid cells (ILC2), a novel lineage-negative lymphocyte population that produces type 2 cytokines, in human allergic disease pathogenesis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29249187/an-update-on-the-management-of-aspirin-exacerbated-respiratory-disease
#14
Ji-Ho Lee, Chang-Gyu Jung, Hae-Sim Park
Clinical features of aspirin-exacerbated respiratory disease (AERD) consist of moderate to severe asthma associated with chronic rhinosinusitis (CRS), which are derived from overproduction of cysteinyl leukotrienes along with chronic type 2 mediated inflammation in the upper and lower airway mucosa. Area covered: This review provides recent up-to-date information regarding phenotypes of AERD and encompasses comprehensive diagnostic methods and treatment options. To confirm the diagnosis of AERD, provocation testing via nasal, inhalation or the oral route of aspirin remains the gold standard; in vitro diagnostic methods are still not available...
February 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29246216/association-analysis-of-ilvbl-gene-polymorphisms-with-aspirin-exacerbated-respiratory-disease-in-asthma
#15
Hun Soo Chang, Jong Sook Park, Ho Sung Lee, Jiwon Lyu, Ji-Hye Son, Inseon S Choi, Hyoung Doo Shin, Choon-Sik Park
BACKGROUND: We previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV1) after an oral aspirin challenge test. In this study, we confirmed the association between polymorphisms and haplotypes of the ILVBL gene and the risk for AERD and its phenotype. METHODS: We recruited 141 AERD and 995 aspirin-tolerant asthmatic (ATA) subjects...
December 16, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29172674/single-nucleotide-polymorphisms-in-tnf-are-associated-with-susceptibility-to-aspirin-exacerbated-respiratory-disease-but-not-to-cytokine-levels-a-study-in-mexican-mestizo-population
#16
Gandhi F Pavón-Romero, Juan M Reséndiz-Hernández, Fernando Ramírez-Jiménez, Gloria Pérez-Rubio, Ángel Camarena, Luis M Terán, Ramcés Falfán-Valencia
AIM: To evaluate the association of three single nucleotide polymorphisms in TNF and one in LTA in Mexican patients with aspirin-exacerbated respiratory disease (AERD) and the correlation of those single nucleotide polymorphisms with serum levels of TNF-α. PATIENTS & METHODS: Case-control study including 133 patients with AERD, 135 patients with asthma (aspirin-tolerant asthmatics) and 182 healthy subjects. RESULTS: GA genotype of rs1800629 in TNF was found to be associated with the risk of developing AERD (p < 0...
December 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29133219/dietary-fatty-acid-modification-for-the-treatment-of-aspirin-exacerbated-respiratory-disease-a-prospective-pilot-trial
#17
Thomas R Schneider, Christina B Johns, Marina L Palumbo, Katherine C Murphy, Katherine N Cahill, Tanya M Laidlaw
BACKGROUND: The high levels of eicosanoid production and the clinical efficacy of leukotriene-modifying pharmacotherapies for patients with aspirin-exacerbated respiratory disease (AERD) suggest that other interventions targeting arachidonic acid dysregulation may also improve disease control. OBJECTIVE: To assess the utility of a high omega-3/low omega-6 diet for the treatment of AERD. METHODS: Prospective, nonblinded dietary intervention in 10 adult patients with AERD at Brigham and Women's Hospital in Boston, MA...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29105347/outcomes-after-complete-endoscopic-sinus-surgery-and-aspirin-desensitization-in-aspirin-exacerbated-respiratory-disease
#18
Nithin D Adappa, Viran J Ranasinghe, Michal Trope, Steven G Brooks, Jordan T Glicksman, Arjun K Parasher, James N Palmer, John V Bosso
BACKGROUND: In this study we assessed patient outcomes after complete endoscopic sinus surgery (ESS) and aspirin desensitization for patients with aspirin-exacerbated respiratory disease (AERD). METHODS: A retrospective chart review was conducted for patients with aspirin challenge-proven AERD who underwent complete ESS followed by aspirin desensitization. Outcomes assessed included need for revision surgery and quality-of-life measures using the 22-item Sino-Nasal Outcomes Test (SNOT-22)...
January 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29035123/physiopathology-and-genetics-in-aspirin-exacerbated-respiratory-disease
#19
Gandhi F Pavón-Romero, Fernando Ramírez-Jiménez, Marco Alejandro Roldán-Alvarez, Luis M Terán, Ramcés Falfán-Valencia
INTRODUCTION: Aspirin-exacerbated respiratory disease (AERD) is a clinical entity characterized by hypersensitivity to aspirin leading to asthma and chronic rhinosinusitis with nasosinusal polyposis. The pathophysiology of the disease involves disruption at the level of arachidonic acid metabolism. Therefore, genetic association studies have been focused on the genes coding this pathway. As other mechanisms involved in the genesis of the disease were elucidated, the corresponding genes were also explored...
October 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28926718/corrigendum
#20
(no author information available yet)
Brunner JP, Jawad BA, McCoul ED. Polypoid change of the middle turbinate and paranasal sinus polyposis are distinct entities. Otolaryngol Head Neck Surg. 2017;157:519-523. (Original doi: 10.1177/0194599817711887) The Results section of this article and its abstract contained several errors in describing data that appears in Tables 1 and 2. The tables contain the correct information, the corrected abstract and article text appears below. Abstract: Results. Of 593 patients, 23 (3.9%) had PCMT and 44 (7.4%) had PSP...
December 2017: Otolaryngology—Head and Neck Surgery
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