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https://www.readbyqxmd.com/read/28048649/tu-h-bra-07-design-construction-and-installation-of-an-experimental-beam-line-for-the-development-of-mri-linac-compatible-electron-accelerator
#1
B Whelan, P Keall, L Holloway, S Gierman, J Schmerge, S Tantawi, A Tremaine, A Trautwein, B Scott, R Fahrig
PURPOSE: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047255/tu-h-brc-09-validation-of-a-novel-therapeutic-x-ray-array-source-and-collimation-system
#2
S Trovati, P Borchard, G J King, C G Limborg, B W Loo, P Maxim, D McCormick, L Y Nicolas, E Schueler, S Tantawi, J Wang, L Wang
PURPOSE: We have experimentally characterized and simulated the dosimetric properties and spatial fidelity of a novel X-ray array source and collimation system called SPHINX that has the potential to generate complex intensity modulated X-ray beams by varying the electron beam intensity only, and without any moving parts like in multi-leaf collimators. METHODS: We investigated the spatial fidelity and the X-ray performances of a SPHINX prototype in tungsten, using a Cyber Knife and the experimental high-energy electron beam line at XTA at SLAC National Laboratory...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27942437/metabolic-engineering-of-serratia-marcescens-mg1-for-enhanced-production-of-3r-acetoin
#3
Xin Lv, Lu Dai, Fangmin Bai, Zhanqing Wang, Liaoyuan Zhang, Yaling Shen
BACKGROUND: Optically pure acetoin (AC) is an important platform chemical which has been widely used to synthesize novel optically active α-hydroxyketone derivatives and liquid crystal composites. RESULTS: In this study, slaC and gldA encoding meso-2,3-butanediol dehydrogenase (meso-2,3-BDH) and glycerol dehydrogenase (GDH), respectively, in S. marcescens MG1 were knocked out to block the conversion from AC to 2,3-butanediol (2,3-BD). The resulting strain MG14 was found to produce a large amount of optically pure (3R)-AC with a little 2,3-BD, indicating that another enzyme responsible for 2,3-BD formation except meso-2,3-BDH and GDH existed in the strain MG1...
2016: Bioresources and Bioprocessing
https://www.readbyqxmd.com/read/27913582/bremsstrahlung-dose-yield-for-high-intensity-short-pulse-laser-solid-experiments
#4
Taiee Liang, Johannes M Bauer, James C Liu, Sayed H Rokni
A bremsstrahlung source term has been developed by the Radiation Protection (RP) group at SLAC National Accelerator Laboratory for high-intensity short-pulse laser-solid experiments between 10(17) and 10(22) W cm(-2) This source term couples the particle-in-cell plasma code EPOCH and the radiation transport code FLUKA to estimate the bremsstrahlung dose yield from laser-solid interactions. EPOCH characterizes the energy distribution, angular distribution, and laser-to-electron conversion efficiency of the hot electrons from laser-solid interactions, and FLUKA utilizes this hot electron source term to calculate a bremsstrahlung dose yield (mSv per J of laser energy on target)...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27910564/high-resolution-x-ray-thomson-scattering-measurements-from-cryogenic-hydrogen-jets-using-the-linac-coherent-light-source
#5
L B Fletcher, U Zastrau, E Galtier, E J Gamboa, S Goede, W Schumaker, A Ravasio, M Gauthier, M J MacDonald, Z Chen, E Granados, H J Lee, A Fry, J B Kim, C Roedel, R Mishra, A Pelka, D Kraus, B Barbrel, T Döppner, S H Glenzer
We present the first spectrally resolved measurements of x-rays scattered from cryogenic hydrogen jets in the single photon counting limit. The 120 Hz capabilities of the LCLS, together with a novel hydrogen jet design [J. B. Kim et al., Rev. Sci. Instrum. (these proceedings)], allow for the ability to record a near background free spectrum. Such high-dynamic-range x-ray scattering measurements enable a platform to study ultra-fast, laser-driven, heating dynamics of hydrogen plasmas. This measurement has been achieved using two highly annealed pyrolytic graphite crystal spectrometers to spectrally resolve 5...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27890248/proximal-row-carpectomy-on-manual-workers-17%C3%A2-patients-followed-for-an-average-of-6%C3%A2-years
#6
S Delclaux, D Israel, C Aprédoaei, M Rongières, P Mansat
: Proximal row carpectomy (PRC) is indicated for the treatment of SNAC or SLAC wrist with preservation of the midcarpal joint. Our hypothesis was that PRC is not appropriate for treating advanced wrist osteoarthritis in patients who carry out heavy manual work. Twenty-three PRCs were performed on 21 patients, 5 women and 16 men with an average age of 54 years (33-77). All patients performed manual work; 11 of them performed heavy manual work. Etiologies were: SLAC wrist in 14 cases (2 stage III, 11 stage II, and 1 stage I) and SNAC wrist in 9 cases (6 stage IIIB and 3 stage IIB)...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27890247/reproducibility-of-x-rays-and-ct-arthrography-in-slac-snac-scac-wrists
#7
R Belhaouane, N Lebeau, C Maes-Clavier, C Hustin, E Krief, B Bonnaire, M Warin, V Rotari, E David
The purpose of this study was to assess the inter-observer and intra-observer reproducibility of the interpretation of CT arthrography and plain X-rays for scapholunate advanced collapse (SLAC), scaphoid non-union advanced collapse (SNAC) and scaphoid chondrocalcinosis advanced collapse (SCAC) wrist conditions, as well as the clinical relevance of these imaging modalities. The CT and X-rays images were reviewed twice in a blinded and randomized manner by two experienced orthopedic surgeons specialized in hand surgery, two orthopedic surgery residents and two experienced radiologists specialized in bone and joint imaging...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27855045/-four-corner-fusion-in-patients-with-wrist-arthritis
#8
María Francisca Vázquez-Alonso, Alberto Viñas-Silva
Scapholunate advance collapse (SLAC) and Scaphoid nonunion advance collapse (SNAC), are the two most common patterns of postraumatic wrist arthritis. SLAC wrist develops after attenuation, either traumatically or atraumatically, of the scapholunate ligament. Atraumatic causes of SLAC wrist include calcium pyrophosphate dehydrate deposition disease, reumathoid arthritis, neuropathic diseases, and b2-microglobulin asociated amyloid deposition diseases. On the other hand, SNAC wrist develops following a scahpoid fracture that has progressed to a nonunion...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27843716/community-assembly-and-functional-leaf-traits-mediate-precipitation-use-efficiency-of-alpine-grasslands-along-environmental-gradients-on-the-tibetan-plateau
#9
Shaowei Li, Jianshuang Wu
The alpine grasslands on the Tibetan Plateau are sensitive and vulnerable to climate change. However, it is still unknown how precipitation use efficiency (PUE), the ratio of aboveground net primary productivity (ANPP) to precipitation, is related to community assembly of plant species, functional groups or traits for the Tibetan alpine grasslands along actual environmental gradients. We conducted a multi-site field survey at grazing-excluded pastures across meadow, steppe and desert-steppe to measure aboveground biomass (AGB) in August, 2010...
2016: PeerJ
https://www.readbyqxmd.com/read/27777815/the-prevalence-of-pisotriquetral-arthritis-in-the-setting-of-scapholunate-advanced-collapse
#10
Schneider K Rancy, Samir K Trehan, Angela E Li, Steve K Lee, Hollis G Potter, Scott W Wolfe
Background Previous authors have reported pisotriquetral pain and subsequent pisiform excision following partial or total wrist fusion in patients with scapholunate advanced collapse (SLAC). Prior studies have not considered the potential role of SLAC biomechanics on pisotriquetral osteoarthritis (PT OA) development preoperatively. Purpose To determine the prevalence and severity of PT OA in patients with SLAC as compared with a control population. Patients and Methods Magnetic resonance imaging (MRI) studies of 24 patients with SLAC wrist and 24 sex- and age-matched control patients were analyzed...
November 2016: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/27746294/molecular-evolution-of-respiratory-syncytial-virus-subgroup-a-genotype-na1-and-on1-attachment-glycoprotein-g-gene-in-central-vietnam
#11
Keisuke Yoshihara, Minh Nhat Le, Koo Nagasawa, Hiroyuki Tsukagoshi, Hien Anh Nguyen, Michiko Toizumi, Hiroyuki Moriuchi, Masahiro Hashizume, Koya Ariyoshi, Duc Anh Dang, Hirokazu Kimura, Lay-Myint Yoshida
We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010-2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated. Bayesian Skyline Plot (BSP) was constructed to analyze the time-trend relative genetic diversity of central Vietnam RSV-A strains...
November 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27725341/source-terms-shielding-calculations-and-soil-activation-for-a-medical-cyclotron
#12
J Konheiser, B Naumann, A Ferrari, C Brachem, S E Müller
Calculations of the shielding and estimates of soil activation for a medical cyclotron are presented in this work. Based on the neutron source term from the (18)O(p,n)(18)F reaction produced by a 28 MeV proton beam, neutron and gamma dose rates outside the building were estimated with the Monte Carlo code MCNP6 (Goorley et al 2012 Nucl. Technol. 180 298-315). The neutron source term was calculated with the MCNP6 code and FLUKA (Ferrari et al 2005 INFN/TC_05/11, SLAC-R-773) code as well as with supplied data by the manufacturer...
October 11, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27711826/femtosecond-gas-phase-electron-diffraction-with-mev-electrons
#13
Jie Yang, Markus Guehr, Theodore Vecchione, Matthew S Robinson, Renkai Li, Nick Hartmann, Xiaozhe Shen, Ryan Coffee, Jeff Corbett, Alan Fry, Kelly Gaffney, Tais Gorkhover, Carsten Hast, Keith Jobe, Igor Makasyuk, Alexander Reid, Joseph Robinson, Sharon Vetter, Fenglin Wang, Stephen Weathersby, Charles Yoneda, Xijie Wang, Martin Centurion
We present results on ultrafast gas electron diffraction (UGED) experiments with femtosecond resolution using the MeV electron gun at SLAC National Accelerator Laboratory. UGED is a promising method to investigate molecular dynamics in the gas phase because electron pulses can probe the structure with a high spatial resolution. Until recently, however, it was not possible for UGED to reach the relevant timescale for the motion of the nuclei during a molecular reaction. Using MeV electron pulses has allowed us to overcome the main challenges in reaching femtosecond resolution, namely delivering short electron pulses on a gas target, overcoming the effect of velocity mismatch between pump laser pulses and the probe electron pulses, and maintaining a low timing jitter...
December 16, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27587106/circular-dichroism-measurements-at-an-x-ray-free-electron-laser-with-polarization-control
#14
G Hartmann, A O Lindahl, A Knie, N Hartmann, A A Lutman, J P MacArthur, I Shevchuk, J Buck, A Galler, J M Glownia, W Helml, Z Huang, N M Kabachnik, A K Kazansky, J Liu, A Marinelli, T Mazza, H-D Nuhn, P Walter, J Viefhaus, M Meyer, S Moeller, R N Coffee, M Ilchen
A non-destructive diagnostic method for the characterization of circularly polarized, ultraintense, short wavelength free-electron laser (FEL) light is presented. The recently installed Delta undulator at the LCLS (Linac Coherent Light Source) at SLAC National Accelerator Laboratory (USA) was used as showcase for this diagnostic scheme. By applying a combined two-color, multi-photon experiment with polarization control, the degree of circular polarization of the Delta undulator has been determined. Towards this goal, an oriented electronic state in the continuum was created by non-resonant ionization of the O2 1s core shell with circularly polarized FEL pulses at hν ≃ 700 eV...
August 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27454635/limited-wrist-arthrodesis-for-scapholunate-advanced-collapse-wrist-triangle-fixation-for-four-corner-fusion
#15
Kosuke Shintani, Kenichi Kazuki, Kiyohito Takamatsu, Masahiro Yoneda, Takuya Uemura
BACKGROUND: Limited wrist arthrodesis with scaphoid excision is a useful treatment for scapholunate advanced collapse (SLAC) of the wrist. Multiple Kirschner wires were originally used for internal fixation of the four carpal bones, however long-term cast immobilization, pin tract infection, and hardware removal are still problematic. We introduce and evaluate the clinical outcomes of an internal fixation technique; triangle fixation for four-corner fusion, using three headless screws, as an alternative to conventional multiple Kirschner wires for the treatment of SLAC wrist...
June 2016: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/27370132/experimental-and-monte-carlo-studies-of-fluence-corrections-for-graphite-calorimetry-in-low-and-high-energy-clinical-proton-beams
#16
Ana Lourenço, Russell Thomas, Hugo Bouchard, Andrzej Kacperek, Vladimir Vondracek, Gary Royle, Hugo Palmans
PURPOSE: The aim of this study was to determine fluence corrections necessary to convert absorbed dose to graphite, measured by graphite calorimetry, to absorbed dose to water. Fluence corrections were obtained from experiments and Monte Carlo simulations in low- and high-energy proton beams. METHODS: Fluence corrections were calculated to account for the difference in fluence between water and graphite at equivalent depths. Measurements were performed with narrow proton beams...
July 2016: Medical Physics
https://www.readbyqxmd.com/read/27366764/ebolavirus-evolves-in-human-to-minimize-the-detection-by-immune-cells-by-accumulating-adaptive-mutations
#17
Arunachalam Ramaiah, Vaithilingaraja Arumugaswami
The current outbreak of Zaire ebolavirus (EBOV) lasted longer than the previous outbreaks and there is as yet no proven treatment or vaccine available. Understanding host immune pressure and associated EBOV immune evasion that drive the evolution of EBOV is vital for diagnosis as well as designing a highly effective vaccine. The aim of this study was to deduce adaptive selection pressure acting on each amino acid sites of EBOV responsible for the recent 2014 outbreak. Multiple statistical methods employed in the study include SLAC, FEL, REL, IFEL, FUBAR and MEME...
June 2016: Virusdisease
https://www.readbyqxmd.com/read/27104694/accelerator-measurements-of-magnetically-induced-radio-emission-from-particle-cascades-with-applications-to-cosmic-ray-air-showers
#18
K Belov, K Mulrey, A Romero-Wolf, S A Wissel, A Zilles, K Bechtol, K Borch, P Chen, J Clem, P W Gorham, C Hast, T Huege, R Hyneman, K Jobe, K Kuwatani, J Lam, T C Liu, J Nam, C Naudet, R J Nichol, B F Rauch, B Rotter, D Saltzberg, H Schoorlemmer, D Seckel, B Strutt, A G Vieregg, C Williams
For 50 years, cosmic-ray air showers have been detected by their radio emission. We present the first laboratory measurements that validate electrodynamics simulations used in air shower modeling. An experiment at SLAC provides a beam test of radio-frequency (rf) radiation from charged particle cascades in the presence of a magnetic field, a model system of a cosmic-ray air shower. This experiment provides a suite of controlled laboratory measurements to compare to particle-level simulations of rf emission, which are relied upon in ultrahigh-energy cosmic-ray air shower detection...
April 8, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27104332/transcapho-perilunate-dislocation-with-palmar-extrusion-of-the-scaphoid-proximal-pole
#19
Augusto Marcuzzi, Massimiliano Leigheb
Perilunate fracture-dislocations usually combine ligament ruptures, bone avulsions, and fractures in different patterns. Rarely a displaced fracture of the scaphoid can coexist with a scapho-lunate dissociation and can result in enucleation of the proximal pole. We report about a case of trans-scaphoid perilunate dislocation with palmar extrusion/enucleation of the scaphoid proximal pole, treated with scaphoid fracture open reduction and internal fixation with screw, scapho-lunate ligament repair with an anchor and vascularization of the scaphoid proximal pole with the 2nd intermetacarpal artery...
2016: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27104327/bone-ligament-bone-cuenod-grafting-technique-modified-by-saffar-romano-for-the-treatment-of-chronic-scapho-lunate-dissociation
#20
Augusto Marcuzzi, Massimiliano Leigheb
BACKGROUND AND AIM OF THE WORK: The authors show their experience about six patients suffering of chronic scapho-lunate (S-L) dissociation treated with the Cuenod method modified by Saffar-Romano. METHODS: Clinical assessment was performed in all patients and compared before and after surgery at follow-up measuring pain value through the VAS, ROM of the wrist with a goniometer, grip strength by Jamar test, functional outcome with the Italian version of the Disability of Arm, Shoulder and Hand (DASH) score...
2016: Acta Bio-medica: Atenei Parmensis
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