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https://www.readbyqxmd.com/read/28473295/amino-acids-located-in-the-outer-sphere-of-the-trinuclear-copper-center-in-a-multicopper-oxidase-cueo-as-the-putative-electron-donor-in-the-four-electron-reduction-of-dioxygen
#1
Takeshi Sakurai, Moe Yamamoto, Shinsuke Ikeno, Kunishige Kataoka
The reaction mechanism of multicopper oxidase (MCO) to reduce dioxygen to water has not been fully understood yet in spite of extensive studies including on the intermediate I (peroxide intermediate) and intermediate II (native intermediate with an O-centered structure at the trinuclear copper center (TNC)). We performed the Phe mutations at the four amino acids, Tyr69, Cys138, Trp139, and Tyr496 located in the outer-sphere of TNC in CueO at the aim of studying whether they play a role as the fourth electron donor to dioxygen or not...
May 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28465193/clinical-outcomes-of-proximal-row-carpectomy-by-preoperative-midcarpal-joint-morphological-classification-viegas-type-i-versus-type-ii
#2
A Toffoli, H Lenoir, C Lazerges, B Coulet, M Chammas
The midcarpal joint can be classified into two anatomical types - Viegas type I and Viegas type II - based on the absence or presence of a medial facet for the hamate on the lunate (lunohamate facet). Type I is associated with a round capitate shape, which theoretically allows better congruence with the lunate fossa of the distal radius following proximal row carpectomy (PRC). This morphological feature has never been considered as a predictive factor of clinical outcome for this surgical procedure. This study aimed to compare the clinical and radiological outcomes of the two Viegas types following PRC...
February 28, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28428913/comparison-of-magnetic-resonance-imaging-and-radiographs-for-evaluation-of-carpal-osteoarthritis
#3
Angela E Li, Steve K Lee, Schneider K Rancy, Alissa J Burge, Hollis G Potter, Scott W Wolfe
Background We sought to evaluate the interobserver and intraobserver reliability of radiographs and magnetic resonance imaging (MRI) for grading of osteoarthritis in patients with scapholunate advanced collapse (SLAC) and scaphoid nonunion advanced collapse (SNAC), and to determine whether MRI is more likely than radiographs to detect carpal osteoarthritis. Methods Radiographs and MR studies of 46 patients with SLAC and SNAC arthritis were reviewed by two hand surgeons and two radiologists and were graded according to severity of osteoarthritis at seven carpal joints...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28398334/diffraction-data-of-core-shell-nanoparticles-from-an-x-ray-free-electron-laser
#4
Xuanxuan Li, Chun-Ya Chiu, Hsiang-Ju Wang, Stephan Kassemeyer, Sabine Botha, Robert L Shoeman, Robert M Lawrence, Christopher Kupitz, Richard Kirian, Daniel James, Dingjie Wang, Garrett Nelson, Marc Messerschmidt, Sébastien Boutet, Garth J Williams, Elisabeth Hartmann, Aliakbar Jafarpour, Lutz M Foucar, Anton Barty, Henry Chapman, Mengning Liang, Andreas Menzel, Fenglin Wang, Shibom Basu, Raimund Fromme, R Bruce Doak, Petra Fromme, Uwe Weierstall, Michael H Huang, John C H Spence, Ilme Schlichting, Brenda G Hogue, Haiguang Liu
X-ray free-electron lasers provide novel opportunities to conduct single particle analysis on nanoscale particles. Coherent diffractive imaging experiments were performed at the Linac Coherent Light Source (LCLS), SLAC National Laboratory, exposing single inorganic core-shell nanoparticles to femtosecond hard-X-ray pulses. Each facetted nanoparticle consisted of a crystalline gold core and a differently shaped palladium shell. Scattered intensities were observed up to about 7 nm resolution. Analysis of the scattering patterns revealed the size distribution of the samples, which is consistent with that obtained from direct real-space imaging by electron microscopy...
April 11, 2017: Scientific Data
https://www.readbyqxmd.com/read/28344525/mri-correlation-of-radial-head-fractures-and-forearm-injuries
#5
Hisham Awan, Robert Goitz
Background: Radial head fractures can be associated with soft tissue injuries of the forearm and wrist. The Essex-Lopresti injury can lead to significant morbidity, especially if the diagnosis is not made acutely. Better identification of such injuries is needed to allow optimal surgical treatment and prevent long-term sequelae. We used magnetic resonance imaging (MRI) to correlate the degree of soft tissue injuries with radial head fractures. Methods: Sixteen pairs of forearms with an associated radial head fracture in 15 patients prospectively underwent an MRI within 2 weeks of their injury...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28169340/enhanced-delignification-of-steam-pretreated-poplar-by-a-bacterial-laccase
#6
Rahul Singh, Jinguang Hu, Matthew R Regner, James W Round, John Ralph, John N Saddler, Lindsay D Eltis
The recalcitrance of woody biomass, particularly its lignin component, hinders its sustainable transformation to fuels and biomaterials. Although the recent discovery of several bacterial ligninases promises the development of novel biocatalysts, these enzymes have largely been characterized using model substrates: direct evidence for their action on biomass is lacking. Herein, we report the delignification of woody biomass by a small laccase (sLac) from Amycolatopsis sp. 75iv3. Incubation of steam-pretreated poplar (SPP) with sLac enhanced the release of acid-precipitable polymeric lignin (APPL) by ~6-fold, and reduced the amount of acid-soluble lignin by ~15%...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28149689/polymorphism-in-the-major-histocompatibility-complex-mhc-class-ii-b-genes-of-the-rufous-backed-bunting-emberiza-jankowskii
#7
Dan Li, Keping Sun, Yunjiao Zhao, Aiqing Lin, Shi Li, Yunlei Jiang, Jiang Feng
Genetic diversity is one of the pillars of conservation biology research. High genetic diversity and abundant genetic variation in an organism may be suggestive of capacity to adapt to various environmental changes. The major histocompatibility complex (MHC) is known to be highly polymorphic and plays an important role in immune function. It is also considered an ideal model system to investigate genetic diversity in wildlife populations. The Rufous-backed Bunting (Emberiza jankowskii) is an endangered species that has experienced a sharp decline in both population and habitat size...
2017: PeerJ
https://www.readbyqxmd.com/read/28119791/combined-tenodesis-capsulodesis-for-scapholunate-instability-minimum-2-year-follow-up
#8
Pablo De Carli, Agustin G Donndorff, Miguel Tovar Torres, Jorge G Boretto, Gerardo L Gallucci
Background The aim of this study is to evaluate the clinical and radiological midterm results of a combined dorsal tenodesis-capsulodesis for static and reducible scapholunate dissociation (SLD). Patients and Methods We evaluated 20 of 22 consecutive patients with static SLD minimum with follow-up of 2 years operated between 2003 and 2012. The mean age was 40 years (range: 23-65 years). Seventeen were men. Final evaluation included comparative wrist range of motion (ROM) and grip strength, pre- and postoperative pain and function by visual analog scale, and QuickDASH and Wrightington scores...
February 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28048649/tu-h-bra-07-design-construction-and-installation-of-an-experimental-beam-line-for-the-development-of-mri-linac-compatible-electron-accelerator
#9
B Whelan, P Keall, L Holloway, S Gierman, J Schmerge, S Tantawi, A Tremaine, A Trautwein, B Scott, R Fahrig
PURPOSE: MRI guided radiation therapy (MRIgRT) is a rapidly growing field; however, Linac operation in MRI fringe fields represents an ongoing challenge. We have previously shown in-silico that Linacs could be redesigned to function in the in-line orientation with no magnetic shielding by adopting an RF-gun configuration. Other authors have also published insilico studies of Linac operation in magnetic fields; however to date no experimental validation data is published. This work details the design, construction, and installation of an experimental beam line to validate our in-silico results...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047255/tu-h-brc-09-validation-of-a-novel-therapeutic-x-ray-array-source-and-collimation-system
#10
S Trovati, P Borchard, G J King, C G Limborg, B W Loo, P Maxim, D McCormick, L Y Nicolas, E Schueler, S Tantawi, J Wang, L Wang
PURPOSE: We have experimentally characterized and simulated the dosimetric properties and spatial fidelity of a novel X-ray array source and collimation system called SPHINX that has the potential to generate complex intensity modulated X-ray beams by varying the electron beam intensity only, and without any moving parts like in multi-leaf collimators. METHODS: We investigated the spatial fidelity and the X-ray performances of a SPHINX prototype in tungsten, using a Cyber Knife and the experimental high-energy electron beam line at XTA at SLAC National Laboratory...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27942437/metabolic-engineering-of-serratia-marcescens-mg1-for-enhanced-production-of-3r-acetoin
#11
Xin Lv, Lu Dai, Fangmin Bai, Zhanqing Wang, Liaoyuan Zhang, Yaling Shen
BACKGROUND: Optically pure acetoin (AC) is an important platform chemical which has been widely used to synthesize novel optically active α-hydroxyketone derivatives and liquid crystal composites. RESULTS: In this study, slaC and gldA encoding meso-2,3-butanediol dehydrogenase (meso-2,3-BDH) and glycerol dehydrogenase (GDH), respectively, in S. marcescens MG1 were knocked out to block the conversion from AC to 2,3-butanediol (2,3-BD). The resulting strain MG14 was found to produce a large amount of optically pure (3R)-AC with a little 2,3-BD, indicating that another enzyme responsible for 2,3-BD formation except meso-2,3-BDH and GDH existed in the strain MG1...
2016: Bioresources and Bioprocessing
https://www.readbyqxmd.com/read/27913582/bremsstrahlung-dose-yield-for-high-intensity-short-pulse-laser-solid-experiments
#12
Taiee Liang, Johannes M Bauer, James C Liu, Sayed H Rokni
A bremsstrahlung source term has been developed by the Radiation Protection (RP) group at SLAC National Accelerator Laboratory for high-intensity short-pulse laser-solid experiments between 10(17) and 10(22) W cm(-2) This source term couples the particle-in-cell plasma code EPOCH and the radiation transport code FLUKA to estimate the bremsstrahlung dose yield from laser-solid interactions. EPOCH characterizes the energy distribution, angular distribution, and laser-to-electron conversion efficiency of the hot electrons from laser-solid interactions, and FLUKA utilizes this hot electron source term to calculate a bremsstrahlung dose yield (mSv per J of laser energy on target)...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27910564/high-resolution-x-ray-thomson-scattering-measurements-from-cryogenic-hydrogen-jets-using-the-linac-coherent-light-source
#13
L B Fletcher, U Zastrau, E Galtier, E J Gamboa, S Goede, W Schumaker, A Ravasio, M Gauthier, M J MacDonald, Z Chen, E Granados, H J Lee, A Fry, J B Kim, C Roedel, R Mishra, A Pelka, D Kraus, B Barbrel, T Döppner, S H Glenzer
We present the first spectrally resolved measurements of x-rays scattered from cryogenic hydrogen jets in the single photon counting limit. The 120 Hz capabilities of the LCLS, together with a novel hydrogen jet design [J. B. Kim et al., Rev. Sci. Instrum. (these proceedings)], allow for the ability to record a near background free spectrum. Such high-dynamic-range x-ray scattering measurements enable a platform to study ultra-fast, laser-driven, heating dynamics of hydrogen plasmas. This measurement has been achieved using two highly annealed pyrolytic graphite crystal spectrometers to spectrally resolve 5...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27890248/proximal-row-carpectomy-on-manual-workers-17%C3%A2-patients-followed-for-an-average-of-6%C3%A2-years
#14
S Delclaux, D Israel, C Aprédoaei, M Rongières, P Mansat
Proximal row carpectomy (PRC) is indicated for the treatment of SNAC or SLAC wrist with preservation of the midcarpal joint. Our hypothesis was that PRC is not appropriate for treating advanced wrist osteoarthritis in patients who carry out heavy manual work. Twenty-three PRCs were performed on 21 patients, 5 women and 16 men with an average age of 54 years (33-77). All patients performed manual work; 11 of them performed heavy manual work. Etiologies were: SLAC wrist in 14 cases (2 stage III, 11 stage II, and 1 stage I) and SNAC wrist in 9 cases (6 stage IIIB and 3 stage IIB)...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27890247/reproducibility-of-x-rays-and-ct-arthrography-in-slac-snac-scac-wrists
#15
R Belhaouane, N Lebeau, C Maes-Clavier, C Hustin, E Krief, B Bonnaire, M Warin, V Rotari, E David
The purpose of this study was to assess the inter-observer and intra-observer reproducibility of the interpretation of CT arthrography and plain X-rays for scapholunate advanced collapse (SLAC), scaphoid non-union advanced collapse (SNAC) and scaphoid chondrocalcinosis advanced collapse (SCAC) wrist conditions, as well as the clinical relevance of these imaging modalities. The CT and X-rays images were reviewed twice in a blinded and randomized manner by two experienced orthopedic surgeons specialized in hand surgery, two orthopedic surgery residents and two experienced radiologists specialized in bone and joint imaging...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27855045/-four-corner-fusion-in-patients-with-wrist-arthritis
#16
María Francisca Vázquez-Alonso, Alberto Viñas-Silva
Scapholunate advance collapse (SLAC) and Scaphoid nonunion advance collapse (SNAC), are the two most common patterns of postraumatic wrist arthritis. SLAC wrist develops after attenuation, either traumatically or atraumatically, of the scapholunate ligament. Atraumatic causes of SLAC wrist include calcium pyrophosphate dehydrate deposition disease, reumathoid arthritis, neuropathic diseases, and b2-microglobulin asociated amyloid deposition diseases. On the other hand, SNAC wrist develops following a scahpoid fracture that has progressed to a nonunion...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27843716/community-assembly-and-functional-leaf-traits-mediate-precipitation-use-efficiency-of-alpine-grasslands-along-environmental-gradients-on-the-tibetan-plateau
#17
Shaowei Li, Jianshuang Wu
The alpine grasslands on the Tibetan Plateau are sensitive and vulnerable to climate change. However, it is still unknown how precipitation use efficiency (PUE), the ratio of aboveground net primary productivity (ANPP) to precipitation, is related to community assembly of plant species, functional groups or traits for the Tibetan alpine grasslands along actual environmental gradients. We conducted a multi-site field survey at grazing-excluded pastures across meadow, steppe and desert-steppe to measure aboveground biomass (AGB) in August, 2010...
2016: PeerJ
https://www.readbyqxmd.com/read/27777815/the-prevalence-of-pisotriquetral-arthritis-in-the-setting-of-scapholunate-advanced-collapse
#18
Schneider K Rancy, Samir K Trehan, Angela E Li, Steve K Lee, Hollis G Potter, Scott W Wolfe
Background Previous authors have reported pisotriquetral pain and subsequent pisiform excision following partial or total wrist fusion in patients with scapholunate advanced collapse (SLAC). Prior studies have not considered the potential role of SLAC biomechanics on pisotriquetral osteoarthritis (PT OA) development preoperatively. Purpose To determine the prevalence and severity of PT OA in patients with SLAC as compared with a control population. Patients and Methods Magnetic resonance imaging (MRI) studies of 24 patients with SLAC wrist and 24 sex- and age-matched control patients were analyzed...
November 2016: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/27746294/molecular-evolution-of-respiratory-syncytial-virus-subgroup-a-genotype-na1-and-on1-attachment-glycoprotein-g-gene-in-central-vietnam
#19
Keisuke Yoshihara, Minh Nhat Le, Koo Nagasawa, Hiroyuki Tsukagoshi, Hien Anh Nguyen, Michiko Toizumi, Hiroyuki Moriuchi, Masahiro Hashizume, Koya Ariyoshi, Duc Anh Dang, Hirokazu Kimura, Lay-Myint Yoshida
We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010-2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated. Bayesian Skyline Plot (BSP) was constructed to analyze the time-trend relative genetic diversity of central Vietnam RSV-A strains...
November 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27725341/source-terms-shielding-calculations-and-soil-activation-for-a-medical-cyclotron
#20
J Konheiser, B Naumann, A Ferrari, C Brachem, S E Müller
Calculations of the shielding and estimates of soil activation for a medical cyclotron are presented in this work. Based on the neutron source term from the (18)O(p,n)(18)F reaction produced by a 28 MeV proton beam, neutron and gamma dose rates outside the building were estimated with the Monte Carlo code MCNP6 (Goorley et al 2012 Nucl. Technol. 180 298-315). The neutron source term was calculated with the MCNP6 code and FLUKA (Ferrari et al 2005 INFN/TC_05/11, SLAC-R-773) code as well as with supplied data by the manufacturer...
December 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
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