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Keisuke Yoshihara, Minh Nhat Le, Koo Nagasawa, Hiroyuki Tsukagoshi, Hien Anh Nguyen, Michiko Toizumi, Hiroyuki Moriuchi, Masahiro Hashizume, Koya Ariyoshi, Duc Anh Dang, Hirokazu Kimura, Lay-Myint Yoshida
We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010-2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated. Bayesian Skyline Plot (BSP) was constructed to analyze the time-trend relative genetic diversity of central Vietnam RSV-A strains...
October 13, 2016: Infection, Genetics and Evolution
J Konheiser, B Naumann, A Ferrari, C Brachem, S E Müller
Calculations of the shielding and estimates of soil activation for a medical cyclotron are presented in this work. Based on the neutron source term from the (18)O(p,n)(18)F reaction produced by a 28 MeV proton beam, neutron and gamma dose rates outside the building were estimated with the Monte Carlo code MCNP6 (Goorley et al 2012 Nucl. Technol. 180 298-315). The neutron source term was calculated with the MCNP6 code and FLUKA (Ferrari et al 2005 INFN/TC_05/11, SLAC-R-773) code as well as with supplied data by the manufacturer...
October 11, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Jie Yang, Markus Guehr, Theodore Vecchione, Matthew S Robinson, Renkai Li, Nick Hartmann, Xiaozhe Shen, Ryan Coffee, Jeff Corbett, Alan Fry, Kelly Gaffney, Tais Gorkhover, Carsten Hast, Keith Jobe, Igor Makasyuk, Alexander Reid, Joseph Robinson, Sharon Vetter, Fenglin Wang, Stephen Weathersby, Charles Yoneda, Xijie Wang, Martin Centurion
We present results on ultrafast gas electron diffraction (UGED) experiments with femtosecond resolution using the MeV electron gun at SLAC National Accelerator Laboratory. UGED is a promising method to investigate molecular dynamics in the gas phase because electron pulses can probe the structure with a high spatial resolution. Until recently, however, it was not possible for UGED to reach the relevant timescale for the motion of the nuclei during a molecular reaction. Using MeV electron pulses has allowed us to overcome the main challenges in reaching femtosecond resolution, namely delivering short electron pulses on a gas target, overcoming the effect of velocity mismatch between pump laser pulses and the probe electron pulses, and maintaining a low timing jitter...
September 20, 2016: Faraday Discussions
G Hartmann, A O Lindahl, A Knie, N Hartmann, A A Lutman, J P MacArthur, I Shevchuk, J Buck, A Galler, J M Glownia, W Helml, Z Huang, N M Kabachnik, A K Kazansky, J Liu, A Marinelli, T Mazza, H-D Nuhn, P Walter, J Viefhaus, M Meyer, S Moeller, R N Coffee, M Ilchen
A non-destructive diagnostic method for the characterization of circularly polarized, ultraintense, short wavelength free-electron laser (FEL) light is presented. The recently installed Delta undulator at the LCLS (Linac Coherent Light Source) at SLAC National Accelerator Laboratory (USA) was used as showcase for this diagnostic scheme. By applying a combined two-color, multi-photon experiment with polarization control, the degree of circular polarization of the Delta undulator has been determined. Towards this goal, an oriented electronic state in the continuum was created by non-resonant ionization of the O2 1s core shell with circularly polarized FEL pulses at hν ≃ 700 eV...
August 2016: Review of Scientific Instruments
Kosuke Shintani, Kenichi Kazuki, Kiyohito Takamatsu, Masahiro Yoneda, Takuya Uemura
BACKGROUND: Limited wrist arthrodesis with scaphoid excision is a useful treatment for scapholunate advanced collapse (SLAC) of the wrist. Multiple Kirschner wires were originally used for internal fixation of the four carpal bones, however long-term cast immobilization, pin tract infection, and hardware removal are still problematic. We introduce and evaluate the clinical outcomes of an internal fixation technique; triangle fixation for four-corner fusion, using three headless screws, as an alternative to conventional multiple Kirschner wires for the treatment of SLAC wrist...
June 2016: J Hand Surg Asian Pac Vol
Ana Lourenço, Russell Thomas, Hugo Bouchard, Andrzej Kacperek, Vladimir Vondracek, Gary Royle, Hugo Palmans
PURPOSE: The aim of this study was to determine fluence corrections necessary to convert absorbed dose to graphite, measured by graphite calorimetry, to absorbed dose to water. Fluence corrections were obtained from experiments and Monte Carlo simulations in low- and high-energy proton beams. METHODS: Fluence corrections were calculated to account for the difference in fluence between water and graphite at equivalent depths. Measurements were performed with narrow proton beams...
July 2016: Medical Physics
Arunachalam Ramaiah, Vaithilingaraja Arumugaswami
The current outbreak of Zaire ebolavirus (EBOV) lasted longer than the previous outbreaks and there is as yet no proven treatment or vaccine available. Understanding host immune pressure and associated EBOV immune evasion that drive the evolution of EBOV is vital for diagnosis as well as designing a highly effective vaccine. The aim of this study was to deduce adaptive selection pressure acting on each amino acid sites of EBOV responsible for the recent 2014 outbreak. Multiple statistical methods employed in the study include SLAC, FEL, REL, IFEL, FUBAR and MEME...
June 2016: Virusdisease
K Belov, K Mulrey, A Romero-Wolf, S A Wissel, A Zilles, K Bechtol, K Borch, P Chen, J Clem, P W Gorham, C Hast, T Huege, R Hyneman, K Jobe, K Kuwatani, J Lam, T C Liu, J Nam, C Naudet, R J Nichol, B F Rauch, B Rotter, D Saltzberg, H Schoorlemmer, D Seckel, B Strutt, A G Vieregg, C Williams
For 50 years, cosmic-ray air showers have been detected by their radio emission. We present the first laboratory measurements that validate electrodynamics simulations used in air shower modeling. An experiment at SLAC provides a beam test of radio-frequency (rf) radiation from charged particle cascades in the presence of a magnetic field, a model system of a cosmic-ray air shower. This experiment provides a suite of controlled laboratory measurements to compare to particle-level simulations of rf emission, which are relied upon in ultrahigh-energy cosmic-ray air shower detection...
April 8, 2016: Physical Review Letters
Augusto Marcuzzi, Massimiliano Leigheb
Perilunate fracture-dislocations usually combine ligament ruptures, bone avulsions, and fractures in different patterns. Rarely a displaced fracture of the scaphoid can coexist with a scapho-lunate dissociation and can result in enucleation of the proximal pole. We report about a case of trans-scaphoid perilunate dislocation with palmar extrusion/enucleation of the scaphoid proximal pole, treated with scaphoid fracture open reduction and internal fixation with screw, scapho-lunate ligament repair with an anchor and vascularization of the scaphoid proximal pole with the 2nd intermetacarpal artery...
2016: Acta Bio-medica: Atenei Parmensis
Augusto Marcuzzi, Massimiliano Leigheb
BACKGROUND AND AIM OF THE WORK: The authors show their experience about six patients suffering of chronic scapho-lunate (S-L) dissociation treated with the Cuenod method modified by Saffar-Romano. METHODS: Clinical assessment was performed in all patients and compared before and after surgery at follow-up measuring pain value through the VAS, ROM of the wrist with a goniometer, grip strength by Jamar test, functional outcome with the Italian version of the Disability of Arm, Shoulder and Hand (DASH) score...
2016: Acta Bio-medica: Atenei Parmensis
Kristen E Garcia, Sofia Babanova, William Scheffler, Mansij Hans, David Baker, Plamen Atanassov, Scott Banta
The engineering of robust protein/nanomaterial interfaces is critical in the development of bioelectrocatalytic systems. We have used computational protein design to identify two amino acid mutations in the small laccase protein (SLAC) from Streptomyces coelicolor to introduce new inter-protein disulfide bonds. The new dimeric interface introduced by these disulfide bonds in combination with the natural trimeric structure drive the self-assembly of SLAC into functional aggregates. The mutations had a minimal effect on kinetic parameters, and the enzymatic assemblies exhibited an increased resistance to irreversible thermal denaturation...
November 2016: Biotechnology and Bioengineering
Abdelsatar Arafa, Ihab El-Masry, Shereen Kholosy, Mohammed K Hassan, Gwenaelle Dauphin, Juan Lubroth, Yilma J Makonnen
BACKGROUND: Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are widely distributed within poultry populations in Egypt and have caused multiple human infections. Linking the epidemiological and sequence data is important to understand the transmission, persistence and evolution of the virus. This work describes the phylogenetic dynamics of H5N1 based on molecular characterization of the hemagglutinin (HA) gene of isolates collected from February 2006 to May 2014. METHODS: Full-length HA sequences of 368 H5N1 viruses were generated and were genetically analysed to study their genetic evolution...
2016: Virology Journal
Michael C Machczynski, Jeffrey T Babicz
Multicopper oxidases (MCO) are the fastest and most efficient known catalysts of the oxygen-reduction reaction. When all four copper ions are oxidized during catalysis, the native intermediate state (NI) decays in seconds to the resting oxidized state (RO), which returns to the catalytic cycle via reduction, but at a much slower rate than NI. We report the long-lived (months at 4°C) NI state of the small laccase (SLAC) MCO and the subsequent characterization of both its RO and NI states by paramagnetic (1)H NMR...
June 2016: Journal of Inorganic Biochemistry
J P Lees, V Poireau, V Tisserand, E Grauges, A Palano, G Eigen, B Stugu, D N Brown, L T Kerth, Yu G Kolomensky, M J Lee, G Lynch, H Koch, T Schroeder, C Hearty, T S Mattison, J A McKenna, R Y So, A Khan, V E Blinov, A R Buzykaev, V P Druzhinin, V B Golubev, E A Kravchenko, A P Onuchin, S I Serednyakov, Yu I Skovpen, E P Solodov, K Yu Todyshev, A J Lankford, J W Gary, O Long, M Franco Sevilla, T M Hong, D Kovalskyi, J D Richman, C A West, A M Eisner, W S Lockman, W Panduro Vazquez, B A Schumm, A Seiden, D S Chao, C H Cheng, B Echenard, K T Flood, D G Hitlin, J Kim, T S Miyashita, P Ongmongkolkul, F C Porter, M Röhrken, R Andreassen, Z Huard, B T Meadows, B G Pushpawela, M D Sokoloff, L Sun, W T Ford, J G Smith, S R Wagner, R Ayad, W H Toki, B Spaan, D Bernard, M Verderi, S Playfer, D Bettoni, C Bozzi, R Calabrese, G Cibinetto, E Fioravanti, I Garzia, E Luppi, V Santoro, A Calcaterra, R de Sangro, G Finocchiaro, S Martellotti, P Patteri, I M Peruzzi, M Piccolo, A Zallo, R Contri, M R Monge, S Passaggio, C Patrignani, B Bhuyan, V Prasad, A Adametz, U Uwer, H M Lacker, U Mallik, C Chen, J Cochran, S Prell, H Ahmed, A V Gritsan, N Arnaud, M Davier, D Derkach, G Grosdidier, F Le Diberder, A M Lutz, B Malaescu, P Roudeau, A Stocchi, G Wormser, D J Lange, D M Wright, J P Coleman, J R Fry, E Gabathuler, D E Hutchcroft, D J Payne, C Touramanis, A J Bevan, F Di Lodovico, R Sacco, G Cowan, D N Brown, C L Davis, A G Denig, M Fritsch, W Gradl, K Griessinger, A Hafner, K R Schubert, R J Barlow, G D Lafferty, R Cenci, B Hamilton, A Jawahery, D A Roberts, R Cowan, R Cheaib, P M Patel, S H Robertson, B Dey, N Neri, F Palombo, L Cremaldi, R Godang, D J Summers, M Simard, P Taras, G De Nardo, G Onorato, C Sciacca, G Raven, C P Jessop, J M LoSecco, K Honscheid, R Kass, M Margoni, M Morandin, M Posocco, M Rotondo, G Simi, F Simonetto, R Stroili, S Akar, E Ben-Haim, M Bomben, G R Bonneaud, H Briand, G Calderini, J Chauveau, Ph Leruste, G Marchiori, J Ocariz, M Biasini, E Manoni, A Rossi, C Angelini, G Batignani, S Bettarini, M Carpinelli, G Casarosa, M Chrzaszcz, F Forti, M A Giorgi, A Lusiani, B Oberhof, E Paoloni, M Rama, G Rizzo, J J Walsh, D Lopes Pegna, J Olsen, A J S Smith, F Anulli, R Faccini, F Ferrarotto, F Ferroni, M Gaspero, A Pilloni, G Piredda, C Bünger, S Dittrich, O Grünberg, M Hess, T Leddig, C Voß, R Waldi, T Adye, E O Olaiya, F F Wilson, S Emery, G Vasseur, D Aston, D J Bard, C Cartaro, M R Convery, J Dorfan, G P Dubois-Felsmann, W Dunwoodie, M Ebert, R C Field, B G Fulsom, M T Graham, C Hast, W R Innes, P Kim, D W G S Leith, S Luitz, V Luth, D B MacFarlane, D R Muller, H Neal, T Pulliam, B N Ratcliff, A Roodman, R H Schindler, A Snyder, D Su, M K Sullivan, J Va'vra, W J Wisniewski, H W Wulsin, M V Purohit, J R Wilson, A Randle-Conde, S J Sekula, M Bellis, P R Burchat, E M T Puccio, M S Alam, J A Ernst, R Gorodeisky, N Guttman, D R Peimer, A Soffer, S M Spanier, J L Ritchie, R F Schwitters, J M Izen, X C Lou, F Bianchi, F De Mori, A Filippi, D Gamba, L Lanceri, L Vitale, F Martinez-Vidal, A Oyanguren, J Albert, Sw Banerjee, A Beaulieu, F U Bernlochner, H H F Choi, G J King, R Kowalewski, M J Lewczuk, T Lueck, I M Nugent, J M Roney, R J Sobie, N Tasneem, T J Gershon, P F Harrison, T E Latham, H R Band, S Dasu, Y Pan, R Prepost, S L Wu
We report on measurements of the decays of B¯ mesons into the semileptonic final states B¯→D^(*)π^(+)π^(-)ℓ^(-)ν¯, where D^(*) represents a D or D^(*) meson and ℓ^(-) is an electron or a muon. These measurements are based on 471×10^(6) BB ¯ pairs recorded with the BABAR detector at the SLAC asymmetric B factory PEP-II. We determine the branching fraction ratios R_{π^{+}π^{-}}^{(*)}=B(B[over ¯]→D^{(*)}π^{+}π^{-}ℓ^{-}ν[over ¯])/B(B[over ¯]→D^{(*)}ℓ^{-}ν[over ¯]) using events in which the second B meson is fully reconstructed...
January 29, 2016: Physical Review Letters
Laura Sevillano, Erik Vijgenboom, Gilles P van Wezel, Margarita Díaz, Ramón I Santamaría
BACKGROUND: Actinomycetes are saprophytic soil bacteria, and a rich source of industrial enzymes. While some of these enzymes can be produced using well-characterized production platforms such as Escherichia coli or Bacillus subtilis, Streptomyces lividans may be the preferred host for proper folding and efficient secretion of active enzymes. A combination of promoters, signal peptides and hosts were tested in order to obtain the best protein expression in this actinomycete. The xylanase, Xys1, from S...
2016: Microbial Cell Factories
Mario Jaborsky, Tobias Maierhofer, Andrea Olbrich, María Escalante-Pérez, Heike M Müller, Judy Simon, Elzbieta Krol, Tracey Ann Cuin, Jörg Fromm, Peter Ache, Dietmar Geiger, Rainer Hedrich
Extrafloral nectaries secrete a sweet sugar cocktail that lures predator insects for protection from foraging herbivores. Apart from sugars and amino acids, the nectar contains the anions chloride and nitrate. Recent studies with Populus have identified a type of nectary covered by apical bipolar epidermal cells, reminiscent of the secretory brush border epithelium in animals. Border epithelia operate transepithelial anion transport, which is required for membrane potential and/or osmotic adjustment of the secretory cells...
May 2016: New Phytologist
Kalenia Márquez-Florez, Enrique Vergara-Amador, Maria Gavilán-Alfonso, Diego Garzón-Alvarado
BACKGROUND AND OBJECTIVE: Carpal fusions are useful for treating specific carpal disorders, maximizing postoperative wrist motion, hand strength, reducing pain and instability of the joint. The surgeon selects the appropriate treatment by considering the degree of stability, the chronicity of the injury, functional demands of the patient and former patient's outcomes as well. However there are not many studies regarding the load distribution provided by the treatment. So, the purpose of this study is to analyze the load distribution through the wrist joint with an arthrodesis treatment and compare the results with a normal wrist...
April 2016: Computer Methods and Programs in Biomedicine
Pedro Augusto Gondim Teixeira, Jacques De Verbizier, Sabine Aptel, Maxime Wack, François Dap, Gilles Dautel, Alain Blum
OBJECTIVE: The purpose of this study is to determine whether the posterior radioscaphoid angle, a marker of posterior displacement of the scaphoid, is associated with degenerative joint disease in patients with scapholunate ligament tears. MATERIALS AND METHODS: Images from 150 patients with wrist pain who underwent CT arthrography and radiography were retrospectively evaluated. Patients with and without scapholunate ligament ruptures were divided into two groups according to CT arthrography findings...
January 2016: AJR. American Journal of Roentgenology
Mohd Faheem Khan, Kush Shrivastava, Rebeka Sinha, Virender Kumar, A K Jaitly
The current dataset is generated via bio-computational approach by surveying of INGI/RIME and SLACS CRE transposable elements (TEs) in latest update of Trypanosoma brucei genome. The distribution dataset (Supplementary File 1) shows the chromosome wise distribution of INGI/RIME and SLACS CRE transposable elements with the status of their -5' and -3' ends, genomic coverage and further elemental description about the completeness on the element. The 5' upstream flanking sequence of 100 bp was then analyzed to find out possible regions that could act as insertion hotspots...
December 2015: Data in Brief
Pak-Cheong Ho, Clara Wing-Yee Wong, Wing-Lim Tse
Background Both the dorsal and the volar portion of the scapholunate interosseous ligament (SLIL) are major stabilizers of the scapholunate (SL) joint. Most reconstruction methods to restore SL stability do not address the volar constraints and frequently fail to reduce the SL gapping. Wrist arthroscopy allows a complete evaluation of the SL interval, accompanying ligament status, and associated SL advanced collapse (SLAC) wrist changes. It enables simultaneous reconstruction of the dorsal and palmar SL ligaments anatomically with the use tendon graft in a boxlike structure...
November 2015: Journal of Wrist Surgery
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