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https://www.readbyqxmd.com/read/29675505/locking-dorsal-plate-in-four-bone-arthrodesis-in-slac-and-snac-3-wrist
#1
Simona Odella, Amos M Querenghi, Francesco M Locatelli, Ugo Dacatra, Elia Creta, Pierluigi Tos
Purpose  The aim of this study was to evaluate the effectiveness and the safety of performing a four-bone arthrodesis (FBA) with dorsal locking plate in patients suffering from stage III scapholunate advanced collapse/scaphoid nonunion advance collapse (SLAC/SNAC) wrist. Methods  We evaluated retrospectively 20 patients surgically treated by a FBA with the use of locking dorsal plate. All the patients were clinically evaluated at follow-up for grip strength, range of motion, and pain (visual analog scale), and with the Disability of the Arm, Shoulder and Hand score and the Mayo wrist score...
March 2018: Joints
https://www.readbyqxmd.com/read/29623579/pharmacokinetics-safety-and-tolerability-of-oral-semaglutide-in-subjects-with-renal-impairment
#2
Charlotte Granhall, Flemming L Søndergaard, Mette Thomsen, Thomas W Anderson
BACKGROUND: Semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been co-formulated with the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) as a tablet for oral administration. This trial (NCT02014259) investigated the pharmacokinetics, safety and tolerability of oral semaglutide in subjects with and without renal impairment. METHODS: Subjects were categorised as having normal renal function (n = 24), mild (n = 12), moderate (n = 12) or severe (n = 12) renal impairment, or end-stage renal disease (ESRD) requiring haemodialysis (n = 11) and received once-daily oral semaglutide (5 mg for 5 days followed by 10 mg for 5 days) in the fasting state, followed by 30 min fasting after dosing...
April 6, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29595703/the-clinical-result-of-arthroscopic-bone-grafting-and-percutaneous-k-wires-fixation-for-management-of-scaphoid-nonunions
#3
Young-Keun Lee, Kwang-Wook Choi, Sang-Hyun Woo, Pak Cheong Ho, Malrey Lee
The purpose of this study is to analyze the clinical results of patients with scaphoid nonunion treated with arthroscopic bone grafting and K (Kirschner)-wires fixation.We retrospectively reviewed the records of 27 patients with scaphoid nonunion who had been treated with arthroscopic bone grafting and K-wires fixation method from November 2008 to February 2014. The average patient age was 35 years. The time from injury to treatment averaged 45 months. The average follow-up period was 18 months. Bone union was assessed using serial plain radiographs...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29568662/-s-nitroso-n-acetyl-l-cysteine-ethyl-ester-snacet-and-n-acetyl-l-cysteine-ethyl-ester-nacet-cysteine-based-drug-candidates-with-unique-pharmacological-profiles-for-oral-use-as-no-h-2-s-and-gsh-suppliers-and-as-antioxidants-results-and-overview
#4
REVIEW
Dimitrios Tsikas, Kathrin S Schwedhelm, Andrzej Surdacki, Daniela Giustarini, Ranieri Rossi, Lea Kukoc-Modun, George Kedia, Stefan Ückert
S -Nitrosothiols or thionitrites with the general formula RSNO are formally composed of the nitrosyl cation (NO+ ) and a thiolate (RS- ), the base of the corresponding acids RSH. The smallest S -nitrosothiol is HSNO and derives from hydrogen sulfide (HSH, H2 S). The most common physiological S -nitrosothiols are derived from the amino acid L-cysteine (CysSH). Thus, the simplest S -nitrosothiol is S -nitroso-L-cysteine (CysSNO). CysSNO is a spontaneous potent donor of nitric oxide (NO) which activates soluble guanylyl cyclase to form cyclic guanosine monophosphate (cGMP)...
February 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29520536/mdct-arthrography-assessment-of-scaphoid-nonunion-advanced-collapse-distribution-of-cartilage-damage-and-relationship-with-scaphoid-nonunion-features
#5
Michel D Crema, Catherine Phan, Anne Miquel, Celine Quach, Lionel Arrivé, Yves Menu
OBJECTIVES: Our primary aim was to evaluate the distribution and severity of cartilage damage in a sample of patients with scaphoid nonunion advanced collapse (SNAC), assessed on MDCT arthrography, with regard to two well-known SNAC staging systems. Secondarily, we wanted to see if the degree of cartilage damage varied with the location of the nonunion. METHODS: We retrospectively included 35 patients with a history of SNAC who had undergone MDCT arthrography. The location of the fracture was defined as the proximal, middle, or distal third of the scaphoid...
March 8, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29509768/trajectories-of-functional-decline-in-older-adults-with-neuropsychiatric-and-cardiovascular-multimorbidity-a-swedish-cohort-study
#6
Davide L Vetrano, Debora Rizzuto, Amaia Calderón-Larrañaga, Graziano Onder, Anna-Karin Welmer, Roberto Bernabei, Alessandra Marengoni, Laura Fratiglioni
BACKGROUND: Functional decline is a strong health determinant in older adults, and chronic diseases play a major role in this age-related phenomenon. In this study, we explored possible clinical pathways underlying functional heterogeneity in older adults by quantifying the impact of cardiovascular (CV) and neuropsychiatric (NP) chronic diseases and their co-occurrence on trajectories of functional decline. METHODS AND FINDINGS: We studied 2,385 people ≥60 years (range 60-101 years) participating in the Swedish National study of Aging and Care in Kungsholmen (SNAC-K)...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29470695/a-banana-nac-transcription-factor-musasnac1-impart-drought-tolerance-by-modulating-stomatal-closure-and-h-2-o-2-content
#7
Sanjana Negi, Himanshu Tak, T R Ganapathi
MusaSNAC1 function in H2 O2 mediated stomatal closure and promote drought tolerance by directly binding to CGT[A/G] motif in regulatory region of multiple stress-related genes. Drought is a abiotic stress-condition, causing reduced plant growth and diminished crop yield. Guard cells of the stomata control photosynthesis and transpiration by regulating CO2 exchange and water loss, thus affecting growth and crop yield. Roles of NAC (NAM, ATAF1/2 and CUC2) protein in regulation of stress-conditions has been well documented however, their control over stomatal aperture is largely unknown...
March 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29439687/3d-analysis-of-osteosyntheses-material-using-semi-automated-ct-segmentation-a-case-series-of-a-4-corner-fusion-plate
#8
Rebecca Woehl, Johannes Maier, Sebastian Gehmert, Christoph Palm, Birgit Riebschlaeger, Michael Nerlich, Michaela Huber
BACKROUND: Scaphoidectomy and midcarpal fusion can be performed using traditional fixation methods like K-wires, staples, screws or different dorsal (non)locking arthrodesis systems. The aim of this study is to test the Aptus four corner locking plate and to compare the clinical findings to the data revealed by CT scans and semi-automated segmentation. METHODS: This is a retrospective review of eleven patients suffering from scapholunate advanced collapse (SLAC) or scaphoid non-union advanced collapse (SNAC) wrist, who received a four corner fusion between August 2011 and July 2014...
February 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29415323/rapidly-developing-multimorbidity-and-disability-in-older-adults-does-social-background-matter
#9
A Calderón-Larrañaga, G Santoni, H X Wang, A K Welmer, D Rizzuto, D L Vetrano, A Marengoni, L Fratiglioni
BACKGROUND: Multimorbidity is among the most disabling geriatric conditions. In this study, we explored whether a rapid development of multimorbidity potentiates its impact on the functional independence of older adults, and whether different sociodemographic factors play a role beyond the rate of chronic disease accumulation. METHODS: A random sample of persons aged ≥60 years (n = 2387) from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) was followed over 6 years...
May 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29249268/treatment-outcomes-of-4-corner-arthrodesis-for-patients-with-advanced-carpal-collapse-an-average-of-4-years-follow-up-comparing-2-different-plate-types
#10
Lisa Reissner, Stefanie Hensler, Sebastian Kluge, Miriam Marks, Daniel B Herren
PURPOSE: The objective was to investigate the clinical and subjective outcomes of patients after 4-corner arthrodesis (FCA) for scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) and to analyze complications. Furthermore, we compared the long-term results of a first-generation nonlocking plate (Spider) and a plate with a locking screw design (Flower plate). METHODS: In a retrospective cohort study, we included 39 patients with stage II or III SLAC or SNAC who underwent FCA...
December 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29205085/incidence-and-survival-of-sinonasal-adenocarcinoma-by-site-and-histologic-subtype
#11
Suat Kılıç, Ruwaa Samarrai, Sarah S Kılıç, Mina Mikhael, Soly Baredes, Jean Anderson Eloy
OBJECTIVE: To determine the incidence and survival of sinonasal adenocarcinoma (SNAC) by subsite and histologic subtype. STUDY DESIGN: Retrospective database review. METHODS: Using the SEER database, we performed a retrospective analysis, identified cases of SNAC diagnosed between 1973 and 2013 and analyzed demographic, histopathology, clinicopathology, and determinants of disease specific survival (DSS). RESULTS: A total of 746 patients with SNAC were identified...
April 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29091493/ten-year-minimum-follow-up-of-4-corner-fusion-for-slac-and-snac-wrist
#12
Purnell Traverso, Anselm Wong, Ronit Wollstein, Lois Carlson, Duffield Ashmead, H Kirk Watson
BACKGROUND: Scapholunate advanced collapse (SLAC) of the wrist is the most common degenerative condition of the wrist. Four-corner fusion (4CF) is performed as salvage surgery, though there is limited information on its long-term results. We hypothesized that 4CF is a durable surgery with good clinical long-term function. METHODS: A retrospective chart review of patients undergoing 4CF as well as an interview and recent radiographs were obtained. Patients with a follow-up period of less than 10 years were excluded...
November 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28898061/postsynthetic-modification-of-bacterial-peptidoglycan-using-bioorthogonal-n-acetylcysteamine-analogs-and-peptidoglycan-o-acetyltransferase-b
#13
Yiben Wang, Klare M Lazor, Kristen E DeMeester, Hai Liang, Tyler K Heiss, Catherine L Grimes
Bacteria have the natural ability to install protective postsynthetic modifications onto its bacterial peptidoglycan (PG), the coat woven into bacterial cell wall. Peptidoglycan O-acetyltransferase B (PatB) catalyzes the O-acetylation of PG in Gram (-) bacteria, which aids in bacterial survival, as it prevents autolysins such as lysozyme from cleaving the PG. We explored the mechanistic details of PatB's acetylation function and determined that PatB has substrate specificity for bioorthgonal short N-acetyl cysteamine (SNAc) donors...
October 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28859830/social-network-analysis-based-classifier-snac-a-case-study-on-time-course-gene-expression-data
#14
Serkan Üçer, Yunuscan Koçak, Tansel Ozyer, Reda Alhajj
BACKGROUND AND OBJECTIVES: Social Network Analysis is an attractive approach to model and analyze complex networks. In recent years, several bioinformatics related networks have been modeled and analyzed thoroughly using social network analysis. The objective of this study is to build a social network analysis based classifier for time sequential data. METHODS: In this work, we model a genomic time sequential data as a 'social' network of interactions. We define interactions as similarity of patients' measurements...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28832197/does-a-comparison-view-improve-the-reliability-of-staging-wrist-osteoarthritis
#15
Paul W L Ten Berg, Tessa Drijkoningen, Thierry G Guitton, David Ring
BACKGROUND: Radiological grading of wrist osteoarthritis associated with scaphoid nonunion advanced collapse (SNAC) can be difficult. A comparison radiograph of the contralateral healthy wrist and an educational training in the various SNAC stages may improve reliability. Our purposes were to evaluate the difference in the reliability: (1) between observers who rate SNAC wrists with and without a comparison radiograph; and (2) between observers who receive training prior to ratings and those who do not...
September 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28809638/-four-corner-arthrodesis-of-the-wrist-with-dorsal-circular-plate-a-retrospective-monocentric-study
#16
T Zatrapa, D Veigl, J Pech, I Landor, M Šimková
PURPOSE OF THE STUDY Our study aimed to evaluate a group of patients who in the period from 2005 to 2014 underwent a four-corner arthrodesis of the wrist in our department. We also wanted to verify the hypothesis as to whether the use of conventional dorsal plate without the application of bone grafts leads to comparable results as the use of dorsal locking plates and routine application of bone grafts. MATERIAL AND METHODS Throughout the years 2005 to 2014 the four-corner arthrodesis of the wrist was performed in our department in a total of 62 patients, in two cases bilaterally...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28791454/-midcarpal-partial-arthrodesis-with-locking-plate-osteosynthesis
#17
REVIEW
J-F Hernekamp, U Kneser, T Kremer, B Bickert
OBJECTIVE: Preservation of residual mobility and pain reduction in the wrist in advanced carpal collapse (scapholunate advanced collapse, SLAC or scaphoid nonunion advanced collapse, SNAC). INDICATIONS: Advanced osteoarthritis of the radiocarpal and intercarpal articulations, SLAC/SNAC stages 2-3. CONTRAINDICATIONS: Arthrotic alterations to the proximal joint surface of the lunate bone or the corresponding joint surface of the radius (lunate fossa)...
August 8, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28776695/three-stress-responsive-nac-transcription-factors-from-populus-euphratica-differentially-regulate-salt-and-drought-tolerance-in-transgenic-plants
#18
Xin Lu, Xiaofei Zhang, Hui Duan, Conglong Lian, Chao Liu, Weilun Yin, Xinli Xia
Stress-responsive NAM, Arabidopsis transcription activation factor 1/2 (ATAF1/2) and CUC2 (SNAC) genes are being used to alter stress tolerance in Arabidopsis or grasses through genetic engineering. However, limited reports are available about the functional characteristics of SNAC in trees. In this study, three putative NAC proteins were identified from Populus euphratica. PeNAC034 and PeNAC045 were classified into the ATAF subgroup and PeNAC036 into the ANAC072 subgroup. These three SNAC transcription factors were localized in the nucleus and contained the transcription activation domain in their C-terminal...
January 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/28756188/long-term-outcomes-of-proximal-row-carpectomy-a-series-of-62-cases
#19
B Chedal-Bornu, D Corcella, A Forli, F Moutet, M Bouyer
The aim of this study was to determine and analyze the functional and radiographic outcomes after proximal row carpectomy (PRC). We hypothesized that this surgery could restore wrist mobility and function in case of radiocarpal osteoarthritis or severe carpal trauma. Sixty-two patients who had undergone PRC were included in this study: 44 patients with wrist osteoarthritis (11 SNAC, 24 SLAC, 3 Kienböck's disease, 6 other) and 18 patients with severe carpal trauma. Each patient underwent clinical (pain, range of motion, grip strength, functional scores) and radiographic evaluations...
October 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28719468/etv6-gene-rearrangements-characterize-a-morphologically-distinct-subset-of-sinonasal-low-grade-non-intestinal-type-adenocarcinoma-a-novel-translocation-associated-carcinoma-restricted-to-the-sinonasal-tract
#20
Simon Andreasen, Alena Skálová, Abbas Agaimy, Justin A Bishop, Jan Laco, Ilmo Leivo, Alessandro Franchi, Stine R Larsen, Daiva Erentaite, Benedicte P Ulhøi, Christian von Buchwald, Linea C Melchior, Michal Michal, Katalin Kiss
Low-grade sinonasal adenocarcinomas (low-grade SNACs) of the sinonasal tract comprise a poorly characterized and histologically heterogeneous group of tumors. We describe three cases of a histologically distinct variant of low-grade SNAC characterized by ETV6 gene rearrangements. The patients included 2 women (aged 32 and 88 y) and a man (aged 75 y); all were initially treated with surgery alone. Follow-up ranged from 9 to 170 months with one patient having 2 local recurrences and none experiencing distant or regional metastases...
November 2017: American Journal of Surgical Pathology
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