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https://www.readbyqxmd.com/read/29928801/understanding-the-interplay-between-self-assembling-peptides-and-solution-ions-for-tunable-protein-nanoparticle-formation
#1
Bhuvana Kamath Shanbhag, Chang Liu, Victoria S Haritos, Lizhong He
Protein based nanomaterials are gaining importance in biomedical and biosensor applications where tunability of the protein particle size is highly desirable. Rationally-designed proteins and peptides offer control over molecular interactions between monomeric protein units to modulate their self-assembly and thus particle formation. Here, using an example enzyme-peptide system produced as a single construct by bacterial expression, we explore how solution conditions affect the formation and size of protein nanoparticles...
June 21, 2018: ACS Nano
https://www.readbyqxmd.com/read/29928655/cortical-alterations-in-phobic-postural-vertigo-a-multimodal-imaging-approach
#2
Pauline Popp, Peter Zu Eulenburg, Thomas Stephan, Rainer Bögle, Maximilian Habs, Peter Henningsen, Regina Feuerecker, Marianne Dieterich
Objective: Functional dizziness syndromes are among the most common diagnoses made in patients with chronic dizziness, but their underlying neural characteristics are largely unknown. The aim of this neuroimaging study was to analyze the disease-specific brain changes in patients with phobic postural vertigo (PPV). Methods: We measured brain morphology, task response, and functional connectivity in 44 patients with PPV and 44 healthy controls. Results: The analyses revealed a relative structural increase in regions of the prefrontal cortex and the associated thalamic projection zones as well as in the primary motor cortex...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928431/p53-positively-regulates-the-expression-of-cancer-stem-cell-marker-cd133-in-hct116-colon-cancer-cells
#3
Xia Chen, Hua Guan, Xiao-Dan Liu, Da-Fei Xie, Yu Wang, Teng Ma, Bo Huang, Ping-Kun Zhou
Colon cancer stem cells (CSCs), which are highly capable of self-renewal and proliferation, are involved in colon tumorigenesis and response to therapy. CD133 is considered the most robust surface marker for colorectal cancer stem cells. Although the TP53 gene is frequently mutated in colon cancer, it remains not fully understood whether and how tumor protein p53 (p53) is associated with CD133 expression in colon cancer cells. In the present study, the expression of the CSC biomarker CD133 was investigated in terms of p53 status in colorectal carcinoma HCT116 cells...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928419/comparative-proteomics-of-side-population-cells-derived-from-human-hepatocellular-carcinoma-cell-lines-with-varying-metastatic-potentials
#4
Hongzhi Liu, Yingchao Wang, Xiaohua Xing, Ying Sun, Dahai Wei, Geng Chen, Qinying Liu, Shanshan Chen, Xiaolong Liu, Jingfeng Liu
Metastasis and recurrence following surgery are major reasons for the high mortality rate and poor prognosis associated with hepatocellular carcinoma (HCC). Cancer stem cells (CSCs) are thought to be able to cause cancer, and to be the primary cause of tumor recurrence and metastasis. The underlying mechanisms of the metastatic potential of CSCs is poorly understood. In the present study, side population (SP) cells were isolated from 4 HCC cell lines, and their self-renewal and migratory abilities were compared...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928366/s100a16-up-regulates-oct4-and-nanog-expression-in-cancer-stem-like-cells-of-yumoto-human-cervical-carcinoma-cells
#5
Nariaki Tomiyama, Ryuji Ikeda, Yukihiko Nishizawa, Shogo Masuda, Yusuke Tajitsu, Yasuo Takeda
Cancer stem-like cells (CSCs), which possess the ability to self-renewal and are multipotent, are regarded as the cause of tumor formation, recurrence, metastasis and drug resistance. It is necessary to understand the properties of CSCs in order to treat them effectively. It has been previously reported that S100 family proteins, which carry calcium-binding EF-hand motifs and are associated with tumorigenic processes, serve crucial roles in maintaining cancer stem-like properties. S100A16 is upregulated in various types of cancer, including bladder, lung and pancreatic...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928002/b-1-cells-and-b-1-cell-precursors-prompt-different-responses-to-wnt-signaling
#6
Lika Osugui, Jolanda J de Roo, Vivian Cristina de Oliveira, Ana Clara Pires Sodré, Frank J T Staal, Ana Flavia Popi
Recently several studies demonstrated a role for the Wnt pathway in lymphocyte development and self-renewal of hematopoietic stem cells (HSCs). B-1 cells constitute a separate lineage of B lymphocytes, originating during fetal hematopoiesis, expressing lymphoid and myeloid markers and possessing self-renewal ability, similar to early hematopoietic progenitors and HSCs. A plethora of studies have shown an important role for the evolutionary conserved Wnt pathway in the biology of HSCs and T lymphocyte development...
2018: PloS One
https://www.readbyqxmd.com/read/29927795/effects-of-the-insight-obesity-preventive-intervention-on-reported-and-observed-infant-temperament
#7
Stephanie Anzman-Frasca, Ian M Paul, Kameron J Moding, Jennifer S Savage, Emily E Hohman, Leann L Birch
OBJECTIVE: Infants higher on negative reactivity and lower on regulation, aspects of temperament, have increased obesity risk. Responsive parenting (RP) has been shown to impact the expression of temperament, including the developing ability to regulate negative emotions. The aim of this analysis was to test the effects of the INSIGHT study's RP intervention designed for the primary prevention of obesity on reported and observed infant negativity and regulation. METHODS: The sample included 240 mother-infant dyads randomized 2 weeks after birth to the RP intervention or a safety control intervention...
June 20, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/29927688/stress-and-obesity
#8
A Janet Tomiyama
Many pathways connect stress and obesity, two highly prevalent problems facing society today. First, stress interferes with cognitive processes such as executive function and self-regulation. Second, stress can affect behavior by inducing overeating and consumption of foods that are high in calories, fat, or sugar; by decreasing physical activity; and by shortening sleep. Third, stress triggers physiological changes in the hypothalamic-pituitary-adrenal axis, reward processing in the brain, and possibly the gut microbiome...
June 21, 2018: Annual Review of Psychology
https://www.readbyqxmd.com/read/29927304/evaluation-of-the-strengths-and-difficulties-questionnaire-dysregulation-profile-sdq-dp
#9
Marike H F Deutz, Qinxin Shi, Helen G M Vossen, Jorg Huijding, Peter Prinzie, Maja Deković, Anneloes L van Baar, Steven Woltering
The Dysregulation Profile (DP) has emerged as a measure of concurrent affective, behavioral and cognitive dysregulation, associated with severe psychopathology, and poor adjustment. While originally developed with the Child Behavior Checklist, more recently the DP has also been defined on the Strengths and Difficulties Questionnaire (SDQ), mostly with a 5-item, but also a 15-item, SDQ-DP measure. This study evaluated the SDQ-DP by examining its factor structure, measurement invariance, and construct validity...
June 21, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29927251/bioreducible-polymeric-nanoparticles-containing-multiplexed-cancer-stem-cell-regulating-mirnas-inhibit-glioblastoma-growth-and-prolong-survival
#10
Hernando Lopez-Bertoni, Kristen Kozielski, Yuan Rui, Bachchu Lal, Hannah Vaughan, David Wilson, Nicole Mihelson, Charles Eberhart, John Laterra, Jordan J Green
Despite our growing molecular understanding of glioblastoma (GBM), treatment modalities remain limited. Recent developments in mechanisms of cell fate regulation and nanomedicine provide new avenues to treat and manage brain tumors via delivery of molecular therapeutics. Here we have developed bioreducible poly(beta-amino ester) nanoparticles that demonstrate high intracellular delivery efficacy, low cytotoxicity, escape from endosomes, and promotion of cytosol-targeted environmentally-triggered cargo release for miRNA delivery to tumor-propagating human cancer stem cells...
June 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29926898/linking-autonomic-physiology-and-emotion-regulation-in-preschoolers-the-role-of-reactivity-and-recovery
#11
Sarah Kahle, Jonas G Miller, Jonathan L Helm, Paul D Hastings
Physiological recovery from negative emotions may be important for effective self-regulation, but little is known about recovery processes in children. The current study investigated links between autonomic physiology, anger expressions, and emotion regulation in a sample of eighty-three 3.5-year-olds. Respiratory sinus arrhythmia and pre-ejection period were measured during an anger induction task as parasympathetic and sympathetic indices, respectively. We examined whether preschoolers' anger expressions and emotion regulation behaviors were associated with individual differences in physiology...
June 21, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29926769/review-of-scientific-self-experimentation-ethics-history-regulation-scenarios-and-views-among-ethics-committees-and-prominent-scientists
#12
Brian P Hanley, William Bains, George Church
We examine self-experimentation ethics history and practice, related law, use scenarios in universities and industry, and attitudes. We show through analysis of the historical development of medical ethics and regulation, from Hippocrates through Good Clinical Practice that there are no ethical barriers to self-experimentation. When the self-experimenter is a true investigator, there is no other party to be protected from unethical behavior. We discuss the n-of-1 issue in self-experiments, and make suggestions for improving experiment design...
June 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29926669/-changes-in-expression-of-autophagy-related-factors-during-acute-contusion-repair-of-skeletal-muscle
#13
Ao Luo, Cheng-Lin Tang, Si-Qin Huang, Dan-Dan Zhao, An-Ning Zhang, Quan-Hu Guo, Rui-Qi Gao, Jing Cao
OBJECTIVES: To explore the possible biological mechanism of skeletal muscle contusion repair through researching the changes in expression of autophagy-related genes and proteins in SD rats with acute skeletal muscle contusion. METHODS: Six rats were randomly selected as the control group from 30 male SD rats, acute skeletal muscle contusion model were established in the remaining 24 rats with self-made hitter, then the model rats were randomly divided into 4 groups (3 d, 5 d, 7 d, 14 d groups, n =6)...
April 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926265/neuroimaging-study-of-alpha-and-beta-eeg-biofeedback-effects-on-neural-networks
#14
Mark B Shtark, Lyudmila I Kozlova, Dmitriy D Bezmaternykh, Mikhail Ye Mel'nikov, Andrey A Savelov, Estate M Sokhadze
Neural networks interaction was studied in healthy men (20-35 years old) who underwent 20 sessions of EEG biofeedback training outside the MRI scanner, with concurrent fMRI-EEG scans at the beginning, middle, and end of the course. The study recruited 35 subjects for EEG biofeedback, but only 18 of them were considered as "successful" in self-regulation of target EEG bands during the whole course of training. Results of fMRI analysis during EEG biofeedback are reported only for these "successful" trainees...
June 2018: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/29925678/the-essential-role-of-double-stranded-rna-dependent-antiviral-signaling-in-the-degradation-of-nonself-single-stranded-rna-in-nonimmune-cells
#15
Sayaka Kimura, Tomoh Matsumiya, Yuko Shiba, Michi Nakanishi, Ryo Hayakari, Shogo Kawaguchi, Hidemi Yoshida, Tadaatsu Imaizumi
The recognition of nonself dsRNA by retinoic acid-inducible gene-I (RIG-I) leads to the engagement of RIG-I-like receptor signaling. In addition, nonself dsRNA triggers a robust latent RNase (RNase L) activation and leads to the degradation of ribosomal structures and cell death. In contrast, nonself ssRNA is known to be recognized by TLR 7/8 in immune cells such as plasmacytoid dendritic cells and B cells, but little is known regarding the involvement of nonself ssRNA in antiviral signaling in nonimmune cells, including epithelial cells...
June 20, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29925408/lncgpr107-drives-the-self-renewal-of-liver-tumor-initiating-cells-and-liver-tumorigenesis-through-gpr107-dependent-manner
#16
Guanqun Huang, Hui Jiang, Ye Lin, Wuzheng Xia, Yuanwei Luo, Yanpeng Wu, Weilong Cai, Xinke Zhou, Xianhan Jiang
BACKGROUND: With self-renewal and differentiation properties, liver tumor initiating cells (TICs) are the reasons for tumor initiation, metastasis and drug resistance. G protein coupled receptors (GPCR) are critical modulators in many physiological and pathological processes. While, their roles in liver TICs are unknown. METHODS: An unbiased screening was performed using online-available data dataset. Liver TICs were sorted by FACS with surface marker CD133, or enriched by oncosphere formation...
June 20, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29923700/cisplatin-encapsulated-polymeric-nanoparticles-with-molecular-geometry-regulated-colloidal-properties-and-controlled-drug-release
#17
Yun-Ho Jeong, Hyeon-Woo Shin, Ji-Yeong Kwon, Sang-Min Lee
Encapsulation of chemotherapeutic agents inside a nanoscale delivery platform can provide an attractive therapeutic strategy with many pharmaceutical benefits, such as increased plasma solubility, prolonged in vivo circulation, and reduced acute toxicity. Given that the biological activities of polymeric nanoparticles are highly dependent on their colloidal structures, the molecular geometry-regulated programming of self-assembled nanoscale architecture is of great interest for chemical design of an ideal delivery platform...
June 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29923259/chronic-pain-in-narcolepsy-type-1-and-type-2-an-underestimated-reality
#18
Renata C Cremaschi, Camila Hirotsu, Sergio Tufik, Fernando M Coelho
Narcolepsy is a rare sleep disorder classified in types 1 and 2. The co-morbidities of narcolepsy type 1, with hypocretin-1 deficiency, are established. Hypocretin-1 in the central and peripheral nervous systems regulates nociception and pain. However, the patients with narcolepsy type 2 have similar excessive daytime sleepiness and co-morbidities without elucidation. The objective of the study was to determine the frequency and the characteristic of chronic pain according to the type of narcolepsy. We also investigated the effect of the interaction between the nutritional status and the type of narcolepsy...
June 19, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29923162/reciprocal-risk-the-longitudinal-relationship-between-emotion-regulation-and-non-suicidal-self-injury-in-adolescents
#19
Kealagh Robinson, Jessica A Garisch, Tahlia Kingi, Madeleine Brocklesby, Angelique O'Connell, Robyn L Langlands, Lynne Russell, Marc S Wilson
No abstract text is available yet for this article.
June 19, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29922711/short-term-lending-payday-loans-as-risk-factors-for-anxiety-inflammation-and-poor-health
#20
Elizabeth Sweet, Christopher W Kuzawa, Thomas W McDade
While research now consistently links consumer financial debt with adverse emotional health outcomes, specific forms of debt and their impact on measures of physical health are underexplored. This gap in knowledge is significant because different forms of loans and debt may have different experiential qualities. In this paper, we focus on a type of unsecured debt - short-term/payday loan borrowing - that has risen dramatically in recent decades in the United States and is characterized by predatory, discriminatory, and poorly regulated lending practices...
August 2018: SSM—Population Health
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