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https://www.readbyqxmd.com/read/29684292/elevated-blood-pressure-and-its-predictors-among-secondary-school-students-in-sarawak-a-cross-sectional-study
#1
Woei Feng Grace Kho, Whye Lian Cheah, Helmy Hazmi
OBJECTIVES: Hypertension is a health issue affecting adolescents. Accumulating evidence affirms that elevated blood pressure begins in childhood and tracks into adulthood. This cross-sectional study was conducted to determine the prevalence of elevated blood pressure and its predictors among secondary school students in Sarawak, Malaysia. METHODS: A total of 2,461 secondary school students aged 12-17 years from 19 schools in Sarawak participated in the study. Questionnaire was used to obtain socio-demographic data, parental history of hypertension, and self-reported physical activity...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684132/prefrontal-cortical-activity-during-the-stroop-task-new-insights-into-the-why-and-the-who-of-real-world-risky-sexual-behavior
#2
Emily Barkley-Levenson, Feng Xue, Vita Droutman, Lynn C Miller, Benjamin J Smith, David Jeong, Zhong-Lin Lu, Antoine Bechara, Stephen J Read
Background: Research suggests that deficits in both executive functioning and trait impulsivity may play a role in risky sexual behavior. At the neural level, differences in regulation of the prefrontal cortex have been linked to impulsivity, measured neurocognitively and through self-report. The relationship between neurocognitive measures of executive control and trait impulsivity in predicting risky sexual behavior has not been investigated. Purpose: To investigate the relationship between neural functioning during the Stroop task and risky sexual behavior, as well as the effect of individual differences in urgent (positive and negative) impulsivity on this relationship...
April 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29683733/cep55-overexpression-causes-male-specific-sterility-in-mice-by-suppressing-foxo1-nuclear-retention-through-sustained-activation-of-pi3k-akt-signaling
#3
Debottam Sinha, Murugan Kalimutho, Josephine Bowles, Ai-Leen Chan, D Jo Merriner, Amanda L Bain, Jacinta L Simmons, Raimundo Freire, J Alejandro Lopez, Robin M Hobbs, Moira K O'Bryan, Kum Kum Khanna
Spermatogenesis is a dynamic process involving self-renewal and differentiation of spermatogonial stem cells, meiosis, and ultimately, the differentiation of haploid spermatids into sperm. Centrosomal protein (CEP)-55 is necessary for somatic cell abscission during cytokinesis. It facilitates equal segregation of cytoplasmic contents between daughter cells by recruiting endosomal sorting complex required for transport machinery (ESCRT) at the midbody. In germ cells, CEP55, in partnership with testes expressed-14 protein (TEX14), has also been shown to be an integral component of intercellular bridge before meiosis...
April 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29683548/universal-ph-responsive-and-metal-ion-free-self-assembly-of-dna-nanostructures
#4
Yongfei Li, Lei Song, Bang Wang, Jianbo He, Yulin Li, Zhaoxiang Deng, Chengde Mao
pH-responsivity has been widely pursued in dynamic DNA nanotechnology, due to its great potential in biosensing, controlled release and nanomachinery. Previously developed pH-triggering systems mostly depend on specific designs of DNA sequences. However, sequence-independent regulation could provide a more general tool to achieve pH-responsive DNA assembly, which has yet to be developed. Herein, we propose a mechanism for dynamic DNA assembly by utilizing ethylenediamine (EN) as a reversibly chargeable (via protonation) cation to overcome electrostatic repulsions...
April 23, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29683435/phospholipid-signaling-in-innate-immune-cells
#5
Valerie B O'Donnell, Jamie Rossjohn, Michael Jo Wakelam
Phospholipids comprise a large body of lipids that define cells and organelles by forming membrane structures. Importantly, their complex metabolism represents a highly controlled cellular signaling network that is essential for mounting an effective innate immune response. Phospholipids in innate cells are subject to dynamic regulation by enzymes, whose activities are highly responsive to activation status. Along with their metabolic products, they regulate multiple aspects of innate immune cell biology, including shape change, aggregation, blood clotting, and degranulation...
April 23, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29682980/aging-and-senescence-associated-changes-of-mesenchymal-stromal-cells-in-myelodysplastic-syndromes
#6
Domenico Mattiucci, Giulia Maurizi, Pietro Leoni, Antonella Poloni
Hematopoietic stem and progenitor cells reside within the bone marrow (BM) microenvironment. By a well-balanced interplay between self-renewal and differentiation, they ensure a lifelong supply of mature blood cells. Physiologically, multiple different cell types contribute to the regulation of stem and progenitor cells in the BM microenvironment by cell-extrinsic and cell-intrinsic mechanisms. During the last decades, mesenchymal stromal cells (MSCs) have been identified as one of the main cellular components of the BM microenvironment holding an indispensable role for normal hematopoiesis...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29682755/only-reappraisers-profit-from-reappraisal-instructions-effects-of-instructed-and-habitual-reappraisal-on-stress-responses-during-interpersonal-conflicts
#7
Heidi Mauersberger, Annekatrin Hoppe, Gudrun Brockmann, Ursula Hess
Conflicts are an undesirable yet common aspect of daily interactions with wide-ranging negative consequences. The present research aimed to examine the buffering effect of experimentally instructed reappraisal on self-reported, physiological and behavioral stress indices during interpersonal conflicts, taking into account habitual emotion regulation strategies. For this, 145 participants experienced a standardized laboratory conflict with the instruction to either reappraise (n = 48), to suppress (n = 50), or with no instruction (n = 47) while cardiovascular and neuroendocrine measures were taken...
April 22, 2018: Psychophysiology
https://www.readbyqxmd.com/read/29681949/cancer-stem-cells-cscs-in-drug-resistance-and-their-therapeutic-implications-in-cancer-treatment
#8
REVIEW
Lan Thi Hanh Phi, Ita Novita Sari, Ying-Gui Yang, Sang-Hyun Lee, Nayoung Jun, Kwang Seock Kim, Yun Kyung Lee, Hyog Young Kwon
Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. Thus, it is important to understand the characteristics and mechanisms by which CSCs display resistance to therapeutic agents. In this review, we highlight the key features and mechanisms that regulate CSC function in drug resistance as well as recent breakthroughs of therapeutic approaches for targeting CSCs...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29681248/effectiveness-of-a-parental-school-based-intervention-to-improve-young-children-s-eating-patterns-a-pilot-study
#9
Ana Isabel Gomes, Luisa Barros, Ana Isabel Pereira, Magda Sofia Roberto
OBJECTIVE: To evaluate the effectiveness of a pilot study of a parental school-based intervention to promote healthy eating behaviours in young children. DESIGN: A quasi-experimental longitudinal design with three conditions (complete intervention (CIG), minimal intervention (MIG), control (CG)), with repeated measures at baseline, immediately after the intervention, 6 months and 1 year after intervention. SETTING: Fourteen public and state-funded kindergartens near Lisbon, Portugal...
April 23, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29680660/evaluation-of-a-self-regulated-in-vitro-hypoxic-system-by-using-chemical-reactions
#10
Ning Han, Zhaotao Wang, Guoqi Wang, Jun Yu, Chen Chen, Huiyong Huang, Ruxiang Xu
In this study, we established an in vitro hypoxic system driven by a self-regulated chemical reaction that proved effective for cell culture. The hypoxic device was modified from a 1.5 L polypropylene preservation box normally employed for food storage. Pyrogallic acid, sodium hydroxide, and sodium carbonate were dissolved in water and injected into the box. Sodium dihydrogen phosphate solution was injected into the box after 15 min. We measured the concentrations of oxygen and carbon dioxide in the box to determine viability of the hypoxic system...
April 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29679558/self-restrained-regulation-of-stem-cell-niche-activity-by-niche-components-in-the-drosophila-testis
#11
Ran Xu, Jing Li, Hang Zhao, Ruiyan Kong, Min Wei, Lin Shi, Guang Bai, Zhouhua Li
Most, if not all, stem cells reside in a defined microenvironment, called the niche. Short-ranged niche signal must be tightly controlled to be active only inside the niche to maintain the proper balance of stem cell self-renewal verse differentiation. However, how niche components restrict localized niche signal activation remains largely unknown. Here, we find that Thickveins (Tkv, a type I receptor of the Dpp signaling pathway) in cyst stem cells (CySCs) of the testis niche prevents Dpp signaling activation outside of the niche...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29679241/therapeutic-approaches-to-type-i-interferonopathies
#12
REVIEW
Marc Bienias, Normi Brück, Constanze Griep, Christine Wolf, Stefanie Kretschmer, Barbara Kind, Victoria Tüngler, Reinhard Berner, Min Ae Lee-Kirsch
To review recent scientific advances and therapeutic approaches in the expanding field of type I interferonopathies. Type I interferonopathies represent a genetically and phenotypically heterogenous group of disorders of the innate immune system caused by constitutive activation of antiviral type I interferon (IFN). Clinically, type I interferonopathies are characterized by autoinflammation and varying degrees of autoimmunity or immunodeficiency. The elucidation of the underlying genetic causes has revealed novel cell-intrinsic mechanisms that protect the organism against inappropriate immune recognition of self nucleic acids by cytosolic nucleic acid sensors...
April 20, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29678114/vertical-stratification-engineering-for-organic-bulk-heterojunction-devices
#13
Liqiang Huang, Gang Wang, Weihua Zhou, Boyi Fu, Xiaofang Cheng, Lifu Zhang, Zhibo Yuan, Sixing Xiong, Lin Zhang, Yuanpeng Xie, Andong Zhang, Youdi Zhang, Wei Ma, Weiwei Li, Yinhua Zhou, Elsa Reichmanis, Yiwang Chen
High efficiency organic solar cells (OSCs) can be produced through optimization of component molecular design, coupled with interfacial engineering and control of active layer morphology. However, vertical stratification of the bulk-heterojunction (BHJ), a spontaneous activity which occurs during the drying process, remains an intricate problem yet to be solved. Routes toward regulating the vertical separation profile and evaluating the effects on the final device should be explored to further enhance the performance of OSCs...
April 20, 2018: ACS Nano
https://www.readbyqxmd.com/read/29677961/last-mile-towards-efficient-healthcare-delivery-in-switzerland-ehealth-enabled-applications-could-speed-up-the-care-process
#14
Yihan Deng, Thomas Bürkle, Jürgen Holm, Erwin Zetz, Kerstin Denecke
A precise and timely care delivery depends on an efficient triage performed by primary care providers and smooth collaboration with other medical specialities. In recent years telemedicine gained increasing importance for efficient care delivery. It's use, however, has been limited by legal issues, missing digital infrastructures, restricted support from health insurances and the digital divide in the population. A new era towards eHealth and telemedicine starts with the establishment of national eHealth regulations and laws...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677623/cerebrospinal-fluid-fgf23-levels-correlate-with-a-measure-of-impulsivity
#15
Hui Li, Zhiyong Cao, Jinzhong Xu, Fan Wang, Rongrong Xiong, Zeping Xu, Xianming Luo, Guohua Li, Xingqi Tan, Zhiyang Liu, Zhiqin Gao, Yimin Kang, Jian Xiao, Yanlong Liu, Xiaokun Li
Fibroblast growth factor 23 (FGF23) is a bone-derived protein produced mainly by osteocytes and osteoblasts and at low levels in specific parts of the brain. It has been shown to associate with mood regulation. Lithium treatment gives rise to significant elevations of serum FGF23 levels in depressive patients. High peripheral blood FGF23 levels correlated with poor cognitive performance in hemodialysis patients. However, no direct evidence demonstrates a relationship between FGF23 and mood regulation. In this study, we aimed to measure the concentration of cerebrospinal fluid (CSF) FGF23 and to explore its relationship with a cluster of emotional characteristics...
April 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677519/suspended-graphene-oxide-nanosheets-maintain-the-self-renewal-of-mouse-embryonic-stem-cells-via-down-regulating-the-expression-of-vinculin
#16
Guoxin Jing, Zhaojie Wang, Xizhen Zhuang, Xiaolie He, Huijun Wu, Qingxiu Wang, Liming Cheng, Zhongmin Liu, Shilong Wang, Rongrong Zhu
Graphene oxide (GO), with good hydrophilicity and biocompatibility, is widely explored as a carrier for various factors in the field of stem cell differentiation. However, its function of sustaining the stemness of mouse embryonic stem cells (mESCs) and the underlying mechanisms of this process remains undiscovered. Herein, we explored the biofunction of GO on mESCs and revealed the involved signaling pathways and key gene. The alkaline phosphatase activity detection, pluripotency genes quantification and the teratomas formation in vivo confirmed that GO nanosheets could sustain the self-renewal ability of mESCs instead of influencing its pluripotency...
April 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29677509/beyond-host-defense-emerging-functions-of-the-immune-system-in-regulating-complex-tissue-physiology
#17
REVIEW
Lucille C Rankin, David Artis
The essential roles played by the immune system in the discrimination between self- versus non/altered-self and its integral role in promoting host defense against invading microbes and tumors have been extensively studied for many years. In these contexts, significant advances have been made in defining the molecular and cellular networks that orchestrate cell-cell communication to mediate host defense and pathogen expulsion. Notably, recent studies indicate that in addition to these classical immune functions, cells of the innate and adaptive immune system also sense complex tissue- and environment-derived signals, including those from the nervous system and the diet...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29676894/homogeneous-time-constants-promote-oscillations-in-negative-feedback-loops
#18
Franco Blanchini, Christian Cuba Samaniego, Elisa Franco, Giulia Giordano
Biological oscillators are present in nearly all self-regulating systems, from individual cells to entire organisms. In any oscillator structure, a negative feedback loop is necessary, but not sufficient to guarantee the emergence of periodic behaviours. The likelihood of oscillations can be improved by careful tuning of the system time constants and by increasing the loop gain, yet it is unclear whether there is any general relationship between optimal time constants and loop gain. This issue is particularly relevant in genetic oscillators resulting from a chain of different subsequent biochemical events, each with distinct (and uncertain) kinetics...
April 20, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29676650/the-pluripotency-factor-musashi-2-is-a-novel-target-for-lung-cancer-therapy
#19
Mary R Zhang, Sichuan Xi, Vivek Shukla, Julie A Hong, Haobin Chen, Yin Xiong, R Taylor Ripley, Chuong D Hoang, David S Schrump
Previously we reported that mithramycin represses multiple pathways critical for stem cell signaling and pluripotency in lung cancer cells. This phenomenon coincided with decreased side population fraction and dramatic dose-dependent growth arrest of lung cancer cells in vitro and in vivo. In the present study, microarray, quantitative reverse transcriptase polymerase chain reaction and immunoblot experiments were performed to further examine the effects of mithramycin on stem cell gene expression in lung cancer cells...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676562/bacterial-cellulose-promotes-long-term-stemness-of-mesc
#20
Tina Tronser, Anna Laromaine, Anna Roig, Pavel A Levkin
Stem cells possess unique properties, such as the ability to self-renew and the potential to differentiate into an organism's various cell types. These make them highly valuable in regenerative medicine and tissue engineering. Their properties are precisely regulated in vivo through complex mechanisms that include multiple cues arising from the cell interaction with the surrounding extracellular matrix, neighboring cells, and soluble factors. Although many research efforts have focused on developing systems and materials that mimic this complex microenvironment, the controlled regulation of differentiation and maintenance of stemness in vitro remains elusive...
April 20, 2018: ACS Applied Materials & Interfaces
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