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Illness Anxiety Disorder

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https://www.readbyqxmd.com/read/28324704/bxd-recombinant-inbred-strains-participate-in-social-preference-anxiety-and-depression-behaviors-along-sex-differences-in-cytokines-and-tactile-allodynia
#1
Caridad López-Granero, Alessandra Antunes Dos Santos, Beatriz Ferrer, Megan Culbreth, Sudipta Chakraborty, Angel Barrasa, Maria Gulinello, Aaron B Bowman, Michael Aschner
Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers...
March 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28314452/social-media-as-it-interfaces-with-psychosocial-development-and-mental-illness-in-transitional-age-youth
#2
REVIEW
Brian A Primack, César G Escobar-Viera
For transitional age individuals, social media (SM) is an integral component of connecting with others. There are 2 billion SM users worldwide. SM users may experience an increase in perceived social support and life satisfaction. Use of SM may facilitate forming connections among people with potentially stigmatizing mental disorders. However, epidemiologic studies suggest that increased SM use is associated with conditions such as depression, anxiety, and sleep disturbance. Future research should examine directionality of these associations and the role of contextual factors...
April 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28298261/efficacy-and-safety-of-agomelatine-10-or-25-mg-day-in-non-depressed-out-patients-with-generalized-anxiety-disorder-a-12-week-double-blind-placebo-controlled-study
#3
Dan J Stein, Antti Ahokas, Marek Jarema, Alla S Avedisova, Livia Vavrusova, Oleg Chaban, Céline Gruget, Valérie Olivier, Françoise Picarel-Blanchot, Christian de Bodinat
Agomelatine is efficacious in reducing symptoms and preventing relapse in placebo-controlled trials in generalised anxiety disorder (GAD). Nevertheless, fixed dose studies of agomelatine in GAD have not been undertaken. To determine the minimally effective optimal dose of agomelatine in GAD, the efficacy of two doses of agomelatine (10 and 25mg/day) was investigated in a 12-week, placebo-controlled, double-blind, international study in patients with a primary diagnosis of GAD. The primary outcome measure was the Hamilton Anxiety scale (HAM-A)...
March 12, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28298187/icanadapt-early-protocol-randomised-controlled-trial-rct-of-clinician-supervised-transdiagnostic-internet-delivered-cognitive-behaviour-therapy-icbt-for-depression-and-or-anxiety-in-early-stage-cancer-survivors-vs-treatment-as-usual
#4
M J Murphy, J M Newby, P Butow, L Kirsten, K Allison, S Loughnan, M A Price, J Shaw, H Shepherd, J Smith, G Andrews
BACKGROUND: This RCT with two parallel arms will evaluate the efficacy of an internet-delivered transdiagnostic cognitive behavioural therapy (iCBT) intervention for the treatment of clinical depression and/or anxiety in early stage cancer survivors. METHODS/DESIGN: Early stage cancer survivors will be recruited via the research arm of a not-for-profit clinical research unit and randomised to an intervention (iCBT) group or a 'treatment as usual' (TAU) control group...
March 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28295762/psychological-impairments-burden-and-spirituality-in-caregivers-of-terminally-ill-cancer-patients
#5
C Lai, M Luciani, C Di Mario, F Galli, E Morelli, P Ginobbi, P Aceto, L Lombardo
The role of spirituality on the psychological health was mostly investigated through studies conducted in terminally ill patients. However, there are not studies investigating the role of religious and spiritual beliefs on psychological state and on burden dimensions in caregivers. The purpose of this study was to investigate the association between spirituality, burden, and psychological state in caregivers of terminally ill cancer patients. Two hundred caregivers of terminally ill patients with cancer were interviewed using Prolonged Grief Disorder 12 (PG-12), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Scale (HAM-D), Caregiver Burden Inventory (CBI) and System of Belief Inventory (SBI-15R)...
March 14, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28293047/personality-driving-behavior-and-mental-disorders-factors-as-predictors-of-road-traffic-accidents-based-on-logistic-regression
#6
Seyyed Salman Alavi, Mohammad Reza Mohammadi, Hamid Souri, Soroush Mohammadi Kalhori, Fereshteh Jannatifard, Ghazal Sepahbodi
BACKGROUND: The aim of this study was to evaluate the effect of variables such as personality traits, driving behavior and mental illness on road traffic accidents among the drivers with accidents and those without road crash. METHODS: In this cohort study, 800 bus and truck drivers were recruited. Participants were selected among drivers who referred to Imam Sajjad Hospital (Tehran, Iran) during 2013-2015. The Manchester driving behavior questionnaire (MDBQ), big five personality test (NEO personality inventory) and semi-structured interview (schizophrenia and affective disorders scale) were used...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28291261/modeling-anorexia-nervosa-transcriptional-insights-from-human-ipsc-derived-neurons
#7
P D Negraes, F R Cugola, R H Herai, C A Trujillo, A S Cristino, T Chailangkarn, A R Muotri, V Duvvuri
Anorexia nervosa (AN) is a complex and multifactorial disorder occurring predominantly in women. Despite having the highest mortality among psychiatric conditions, it still lacks robust and effective treatment. Disorders such as AN are most likely syndromes with multiple genetic contributions, however, genome-wide studies have been underpowered to reveal associations with this uncommon illness. Here, we generated induced pluripotent stem cells (iPSCs) from adolescent females with AN and unaffected controls...
March 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28291058/comparing-affiliate-stigma-between-family-caregivers-of-people-with-different-severe-mental-illness-in-taiwan
#8
Chih-Cheng Chang, Cheng-Fang Yen, Fong-Lin Jang, Jian-An Su, Chung-Ying Lin
The family caregivers of people with mental illness may internalize the public stereotypes into the affiliate stigma (i.e., the self-stigma of family members). This study aimed to compare the affiliate stigma across schizophrenia, bipolar disorder, and major depressive disorder, and to investigate potential factors associated with affiliate stigma. Each caregiver of family members with schizophrenia (n = 215), bipolar disorder (n = 85), and major depressive disorder (n = 159) completed the Affiliate Stigma Scale, Rosenberg Self-Esteem Scale, Caregiver Burden Inventory, Taiwanese Depression Questionnaire, and Beck Anxiety Inventory...
March 13, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28290733/comparing-mental-health-literacy-and-physical-health-literacy-an-exploratory-study
#9
Robert Wickstead, Adrian Furnham
BACKGROUND: This study compared mental health and physical health literacy using five health problems from each area. AIMS: The aim was to determine whether the same group had better physical than mental health literacy Method: A sample of 263 participants completed an online questionnaire requiring them to name a problem/illness described in 10 vignettes and suggest treatment options. Five vignettes described mental health problems (anxiety, bipolar-disorder, depression, OCPD and schizophrenia) and five physical problems (angina, COPD, diabetes, a heart attack, and sinusitis)...
March 14, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28285469/health-related-quality-of-life-anxiety-and-depression-in-bariatric-surgery-candidates-compared-to-patients-from-a-psychosomatic-inpatient-hospital
#10
Alexandra Osterhues, Thomas von Lengerke, Julian W Mall, Martina de Zwaan, Astrid Müller
BACKGROUND AND AIM: Past research indicated high psychiatric comorbidity and poor health-related quality of life (HRQOL) in patients seeking surgical treatment for obesity. This study investigated if preoperative bariatric surgery patients perceive equally poor HRQOL and increased levels of anxiety and depression as mentally ill patients. METHODS: The study included four groups: 192 bariatric surgery candidates (PRE, 71% women, BMI 48.35 ± 8.98 kg/m(2)), 96 psychotherapy inpatients with mental disorders (PSY, 77% women, BMI 27...
March 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28285242/psychophysiological-correlates-of-emotion-regulation-training-in-adolescent-anxiety-evidence-from-the-novel-pier-task
#11
Nele A J De Witte, Stefan Sütterlin, Caroline Braet, Sven C Mueller
BACKGROUND: Anxiety disorders are the leading cause of mental illness in adolescence. While anxious adolescents show impairments in emotion processing and deficits in emotion regulation, few studies have attempted to improve emotion regulation within these populations. METHOD: This study used a multi-method design to test a newly developed emotion regulation training aimed at improving insight into emotions and instructing cognitive reappraisal. The efficacy of cognitive reappraisal was investigated in 27 clinically anxious youth (Age: M=12...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28284951/hippocampal-bdnf-overexpression-or-micror124a-silencing-reduces-anxiety-and-autism-like-behaviors-in-rats
#12
Amine Bahi
MicroRNA124a (miR124a) has emerged recently as a key player for multiple neuropsychiatric disorders including depression, anxiety, alcoholism, and cocaine addiction. Although we have previously reported that miR124a and its target the brain-derived neutrophic factor (BDNF) play an important role in autism-like behaviors, the molecular and behavioral dysfunctions remain unknown. The aim of this study was to understand the effects of sustained decreases in miR124a and increases of BDNF in the dentate gyrus (DG) on neonatal isolation-induced anxiety-and autism like behaviors in rats...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28279571/sex-dependent-mental-illnesses-and-mitochondria
#13
REVIEW
Akiko Shimamoto, Virginie Rappeneau
The prevalence of some mental illnesses, including major depression, anxiety-, trauma-, and stress-related disorders, some substance use disorders, and later onset of schizophrenia, is higher in women than men. While the higher prevalence in women could simply be explained by socioeconomic determinants, such as income, social status, or cultural background, extensive studies show sex differences in biological, pharmacokinetic, and pharmacological factors contribute to females' vulnerability to these mental illnesses...
March 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28276176/user-profiles-of-an-electronic-mental-health-tool-for-ecological-momentary-assessment-memind
#14
María Luisa Barrigón, Sofian Berrouiguet, Juan José Carballo, Covadonga Bonal-Giménez, Pablo Fernández-Navarro, Bernadette Pfang, David Delgado-Gómez, Philippe Courtet, Fuensanta Aroca, Jorge Lopez-Castroman, Antonio Artés-Rodríguez, Enrique Baca-García
Ecological momentary assessment (EMA) is gaining importance in psychiatry. This article assesses the characteristics of patients who used a new electronic EMA tool: the MEmind Wellness Tracker. Over one year, 13811 adult outpatients in our Psychiatry Department were asked to use MEmind. We collected information about socio-demographic data, psychiatric diagnoses, illness severity, stressful life events and suicidal thoughts/behavior. We compared active users (N = 2838) and non-active users (N = 10,973) of MEmind and performed a Random Forest analysis to assess which variables could predict its use...
March 9, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28274333/smoking-and-common-mental-disorders-in-patients-with-chronic-conditions-an-analysis-of-data-collected-via-a-web-based-screening-system
#15
Faith Matcham, Amy Carroll, Natali Chung, Victoria Crawford, James Galloway, Anna Hames, Karina Jackson, Clare Jacobson, Dulka Manawadu, Lance McCracken, John Moxham, Lauren Rayner, Deborah Robson, Anna Simpson, Nicky Wilson, Matthew Hotopf
OBJECTIVE: Smoking is the largest preventable cause of death and disability in the UK and remains pervasive in people with mental disorders and in general hospital patients. We aimed to quantify the prevalence of mental disorders and smoking, examining associations between mental disorders and smoking in patients with chronic physical conditions. METHOD: Data were collected via routine screening systems implemented across two London NHS Foundation Trusts. The prevalence of mental disorder, current smoking, nicotine dependence and wanting help with quitting smoking were quantified, and the relationships between mental disorder and smoking were examined, adjusting for age, gender and physical illness, with multiple regression models...
March 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28273041/the-burden-of-generalized-anxiety-disorder-in-canada
#16
Louise Pelletier, Siobhan O'Donnell, Louise McRae, Jean Grenier
INTRODUCTION: Although generalized anxiety disorder (GAD) is common and disabling, there are few Canadian studies on this mental illness. We compared the characteristics, health status, health services use and health care needs of Canadians with GAD to those with depression. METHODS: Data are from the 2012 Canadian Community Health Survey-Mental Health, which surveyed a nationally representative sample of Canadians aged 15 years and older (n = 23 709; response rate of 68...
February 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28260904/quality-of-life-self-stigma-and-hope-in-schizophrenia-spectrum-disorders-a-cross-sectional-study
#17
Kristyna Vrbova, Jan Prasko, Marie Ociskova, Dana Kamaradova, Marketa Marackova, Michaela Holubova, Ales Grambal, Milos Slepecky, Klara Latalova
GOALS: The aim of this study was to explore the quality of life, self-stigma, personality traits, and hope in patients with schizophrenia spectrum disorders. PATIENTS AND METHODS: A total of 52 outpatients participated in this cross-sectional study. The attending psychiatrist assessed each patient with Mini International Neuropsychiatric Interview (MINI). The patients then completed Quality of Life Satisfaction and Enjoyment Questionnaire (Q-LES-Q), Internalized Stigma of Mental Illness (ISMI) Scale, Temperament and Character Inventory - Revised (TCI-R), Adult Dispositional Hope Scale (ADHS), Drug Attitude Inventory 10 (DAI-10), and Liebowitz Social Anxiety Scale (LSAS)-Self-report...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28256473/antidepressant-anxiolytic-activities-of-n-pyridin-3-yl-quinoxalin-2-carboxamide-a-novel-serotonin-type-3-receptor-antagonist-in-behavioural-animal-models
#18
Dilip Kumar Pandey, Thangraj Devadoss, Neha Modak, Radhakrishnan Mahesh
BACKGROUND & OBJECTIVES: Alteration in the serotonin leads to the psychological illness, such as depression, anxiety, schizophrenia, eating disorders, obsessive-compulsive disorder, panic disorders and migraines. The objective of the current study was to investigate the antidepressant and anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide (QCF-21), a novel 5-HT3receptor antagonist in preclinical models of depression and anxiety. METHODS: Antidepressant activity was evaluated in preliminary tests such as forced swim and tail suspension tests (FST & TST)...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28255435/the-effect-of-long-acting-paliperidone-palmitate-once-monthly-on-negative-and-depressive-symptoms-in-patients-with-schizophrenia-switched-from-previous-unsuccessful-treatment-with-oral-aripiprazole
#19
Andreas Schreiner, Paul Bergmans, Pierre Cherubin, Ludger Hargarter
BACKGROUND: The negative symptoms of schizophrenia are generally harder to recognize, more difficult to treat than positive symptoms, and have a significant impact on patient functioning and overall outcomes. Treatment with aripiprazole may be associated with benefits on negative symptoms and functioning given its partial agonism to the dopamine D2 receptor. The aim of this subanalysis was to explore the impact of flexibly dosed, long-acting paliperidone palmitate once monthly (PP1M) on negative and depressive symptoms, disorganized thoughts, anxiety, extrapyramidal symptoms, and patient functioning in nonacute adult patients with schizophrenia previously unsuccessfully treated with oral aripiprazole monotherapy...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28252881/a-randomized-controlled-pilot-study-on-mindfulness-based-cognitive-therapy-for-unipolar-depression-in-patients-with-chronic-pain
#20
Marasha de Jong, Frenk Peeters, Tim Gard, Heidi Ashih, Jim Doorley, Rosemary Walker, Laurie Rhoades, Ronald J Kulich, Karsten D Kueppenbender, Jonathan E Alpert, Elizabeth A Hoge, Willoughby B Britton, Sara W Lazar, Maurizio Fava, David Mischoulon
OBJECTIVE: Chronic pain is a disabling illness, often comorbid with depression. We performed a randomized controlled pilot study on mindfulness-based cognitive therapy (MBCT) targeting depression in a chronic pain population. METHOD: Participants with chronic pain lasting ≥ 3 months; DSM-IV major depressive disorder (MDD), dysthymic disorder, or depressive disorder not otherwise specified; and a 16-item Quick Inventory of Depressive Symptomatology-Clinician Rated (QIDS-C₁₆) score ≥ 6 were randomly assigned to MBCT (n = 26) or waitlist (n = 14)...
February 28, 2017: Journal of Clinical Psychiatry
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