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https://www.readbyqxmd.com/read/27781369/ion-channels-ion-channel-receptors-and-visceral-hypersensitivity-in-irritable-bowel-syndrome
#1
REVIEW
I M Fuentes, J A Christianson
Ion channels are expressed throughout the gastrointestinal system and regulate nearly every aspect of digestion, including fluid secretion and absorption, motility, and visceral sensitivity. It is therefore not surprising that in the setting of functional bowel disorders, such as irritable bowel syndrome (IBS), ion channels are often altered in terms of expression level and function and are a target of pharmacological intervention. This is particularly true of their role in driving abdominal pain through visceral hypersensitivity (VH), which is the main reason IBS patients seek medical care...
November 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27719737/the-other-side-of-vitamin-d-therapy-%C3%A2-a-case-series-of-acute-kidney-injury-due-to-malpractice-related-vitamin-d-intoxication%C3%A2
#2
Muzafar Wani, Imtiaz Wani, Khurshid Banday, Mohd Ashraf
BACKGROUND: Vitamin D deficiency is highly prevalent in Indian Kashmir. Many people get injectable vitamin D (600,000 IU/injection). At times, the dose prescribed is far above the permissible limit. We report 62 patients with malpractice-related vitamin D intoxication, presenting with hypercalcemia and acute kidney injury (AKI). METHODS: The diagnosis was made on basis of (1) history of multiple intramuscular vitamin D injections (2) toxic serum levels of 25-OH vitamin D and (3) exclusion of common causes of hypercalcemia (malignancy and hyperparathyroidism)...
November 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27554920/successful-treatment-of-limy-bile-syndrome-extending-to-the-common-bile-duct-by-laparoscopic-cholecystectomy-and-common-bile-duct-exploration-a-case-report-and-literature-review
#3
Yuka Masuda, Yoshiaki Mizuguchi, Tomohiro Kanda, Hiroyasu Furuki, Yasuhiro Mamada, Nobuhiko Taniai, Yoshiharu Nakamura, Masato Yoshioka, Akira Matsushita, Yoichi Kawano, Tetsuya Shimizu, Eiji Uchida
Limy bile syndrome extending to the common bile duct (CBD) is a rare condition that lacks a standardized treatment. Laparoscopic cholecystectomy with laparoscopic choledocholithotomy by CBD exploration is preferred because it preserves the function of the sphincter of the Vater's papilla and allows treatment of both lesions. A 37-year-old man who was receiving entecavir for chronic hepatitis B developed right upper quadrant pain. Abdominal ultrasonography revealed a calcified shadow in the gallbladder and CBD...
August 24, 2016: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/27506562/acute-pancreatitis-and-pneumonia-due-to-mycoplasma-pneumoniae-a-case-report
#4
Michael Benzaquen, Dan Lebowitz, Pauline Belenotti, Jean-Marc Durand, Jacques Serratrice
BACKGROUND: Mycoplasma pneumoniae is a bacterium responsible for 15 to 40 % of acute community-acquired pneumonia in children and 20 % of adult cases. Several extrapulmonary manifestations have been reported. We report a rare case of an adult patient suffering from pneumonia associated with an acute pancreatitis in the setting of Mycoplasma pneumoniae infection. CASE PRESENTATION: A 28-year-old Caucasian woman was referred for anorexia lasting for 1 week. Her past medical history was notable for congenital hydrocephalus with consecutive ventriculo-peritoneal shunt, epilepsia and paraparesis...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27478669/vitamin-d-and-risk-for-vitamin-a-intoxication-in-an-18-month-old-boy
#5
Valentina Talarico, Massimo Barreca, Rossella Galiano, Maria Concetta Galati, Giuseppe Raiola
An 18-month-old boy presented with abdominal pain, vomiting, diarrhea, and poor appetite for 6 days. He had been given a multivitamin preparation once daily, containing 50.000 IU of vitamin D and 10.000 IU of vitamin A for a wide anterior fontanelle for about three months. He presented with hypercalcemia, low levels of parathyroid hormone (PTH), and very high serum 25-hydroxyvitamin D (25-OHD) levels. Renal ultrasound showed nephrocalcinosis. He did not have sign or symptom of vitamin A intoxication. Patient was successfully treated with intravenous hydration, furosemide, and prednisolone...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27462009/a-randomized-double-blind-multicenter-placebo-controlled-study-to-evaluate-the-efficacy-and-safety-of-oral-salmon-calcitonin-in-the-treatment-of-osteoporosis-in-postmenopausal-women-taking-calcium-and-vitamin-d
#6
Kim Henriksen, Inger Byrjalsen, Jeppe R Andersen, Asger R Bihlet, Luis A Russo, Peter Alexandersen, Ivo Valter, Per Qvist, Edith Lau, Bente J Riis, Claus Christiansen, Morten A Karsdal
This randomized, double-blind, placebo-controlled phase III study was conducted to assess the efficacy and safety of oral calcitonin (SMC021) for the treatment of postmenopausal osteoporosis. A total of 4665 postmenopausal women with osteoporosis were randomized 1:1 to receive calcium and vitamin D plus either SMC021 tablets (0.8mg/d) or placebo for 36months. The primary endpoint was the proportion of patients with a new vertebral fracture. The two groups were well balanced at baseline with regards to demographic and clinical data...
October 2016: Bone
https://www.readbyqxmd.com/read/27460661/severe-hypercalcemia-in-a-postpartum-patient
#7
Megan L Murphy, Michael J Mattingly, Craig T Meisner
BACKGROUND: There are multiple clinical manifestations of hypercalcemia and several causes of hypercalcemia. Hypercalcemia caused by milk-alkali syndrome is increasing in frequency. CASE REPORT: A 26-year-old woman presented after having undergone caesarian section. She complained of severe myalgias, arthralgias, an inability to ambulate, nausea, vomiting, abdominal pain, and marked depression. Each of these symptoms has a broad differential diagnosis, but when considered together the theme "stones, bones, moans, and groans," seen in patients with hypercalcemia, is evident...
October 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27440277/intestinal-lymphangiectasia-insights-on-management-and-literature-review
#8
Mohamad J Alshikho, Joud M Talas, Salem I Noureldine, Saf Zazou, Aladdin Addas, Haitham Kurabi, Mahmoud Nasser
BACKGROUND Intestinal lymphangiectasia (IL) is a rare disease characterized by a dilatation of the intestinal lymphatics and loss of lymph fluid into the gastrointestinal tract leading to hypoproteinemia, edema, lymphocytopenia, hypogammaglobinemia, and immunological abnormalities. Iron, calcium, and other serum components (e.g., lipids, fat soluble vitamins) may also be depleted. A literature search revealed more than 200 reported cases of IL. Herein, we report our observations of a patient diagnosed with IL; we also present our conclusion for our review of the published literature...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27277007/management-challenges-with-brown-tumor-of-primary-hyperparathyroidism-masked-by-severe-vitamin-d-deficiency-a-case-report
#9
Marya Hussain, Montasir Hammam
BACKGROUND: Hyperparathyroidism is a disease characterized by excessive secretion of parathyroid hormone, the hormone responsible for calcium and phosphate homeostasis in the body. It can be of three types: primary, secondary, or tertiary. It is essential to bear in mind that in any one patient more than one type of hyperparathyroidism may be found, which may create perplexity regarding the etiology of the case. Hyperparathyroidism can become apparent early in its course when a patient presents with symptoms of abdominal pain, recurrent renal calculi, repeated fractures, or behavior changes...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27196538/colonic-overexpression-of-the-t-type-calcium-channel-cav-3-2-in-a-mouse-model-of-visceral-hypersensitivity-and-in-irritable-bowel-syndrome-patients
#10
J Scanzi, A Accarie, E Muller, B Pereira, Y Aissouni, M Goutte, J Joubert-Zakeyh, E Picard, L Boudieu, C Mallet, A Gelot, D Ardid, F A Carvalho, M Dapoigny
BACKGROUND: Among the different mechanisms involved in irritable bowel syndrome (IBS) physiopathology, visceral hypersensitivity seems to play a key role. It involves sensitization of the colonic primary afferent fibers, especially through an overexpression of ion channels. The aims of this translational study were to investigate the colonic expression of Cav 3.2 calcium channels and their involvement in an animal model of colonic hypersensitivity, and to assess their expression in the colonic mucosa of symptomatic IBS patients...
May 15, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27123071/%C3%AE-fetoprotein-producing-gastric-carcinoma-a-case-report-of-a-rare-subtype-and-literature-review
#11
Ningbo Sun, Qing Sun, Qun Liu, Tianxiao Zhang, Qiang Zhu, Wei Wang, Ming Cao, Q I Zang
α-fetoprotein (AFP)-producing gastric carcinoma is a rare type of gastric cancer, and the characteristics have not yet been fully elucidated. The present study reports the case of a patient with this type of gastric cancer. A 66-year-old male was referred to the Department of Gastrointestinal Surgery, Qianfoshan Hospital, Shandong University (Jinan, China) with a 20-day history of retrosternal pain. A computed tomography (CT) scan revealed a thickening of the wall of the cardia and massive lymph node swelling in the region of the lesser curvature of the stomach...
May 2016: Oncology Letters
https://www.readbyqxmd.com/read/26937260/radiological-features-of-long-standing-hypoparathyroidism
#12
Deepa Regina John, Pokhraj P Suthar
BACKGROUND: Idiopathic hypoparathyroidism is an extremely rare endocrinal disorder with a prevalence of 37 per 100,000. Herein we presented a case of a 30-year-old male who came with symptoms of muscle weakness, carpopedal spasms and limitation of movement which gradually progressed over 8 years. CASE REPORT: A 30-year-old male patient presented in an outpatient department of a tertiary care centre with a complaint of severe pain in both hip joints. He had generalized muscle weakness, facial discomfort, recurrent episodes of carpopedal spasms and crampy abdominal pains...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/26933485/severe-abdominal-pain-caused-by-lead-toxicity-without-response-to-oral-chelators-a-case-report
#13
Hassan Vossoughinia, Ali Pourakbar, Samaneh Esfandiari, Masoud Sharifianrazavi
A 19-year-old woman was referred to the Emergency Surgery Department with severe abdominal pain, icterus, and anemia. The patient's clinical and paraclinical findings in addition to her occupational and social history, convinced us to assay blood lead level (BLL), which was 41/5 μg/dL. Therefore toxicology consult was performed to treat lead toxicity. Recheck of the BLL showed the level as 53/7 μg/dL. So oral chelator with succimer was started. Despite consumption of oral chelator, there was no response and the pain continued...
January 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/26604950/primary-hyperparathyroidism-presenting-with-acute-pancreatitis-and-asymptomatic-bone-involvement
#14
Aasem Saif
A 15-year-old female patient presented to the emergency room with vomiting and abdominal pain. She had two similar attacks in the previous three months both of them were diagnosed as pancreatitis in two different hospitals. On admission, her serum calcium and parathyroid hormone levels were very high. CT scan revealed left inferior parathyroid adenoma. Investigations to rule out possible multiple endocrine neoplasia were all negative. The patient was managed by intravenous fluids and furosemide to lower her serum calcium level...
May 2015: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/26078734/an-unexpected-result-of-obesity-treatment-orlistat-related-acute-pancreatitis
#15
Murat Kose, Samim Emet, Timur Selcuk Akpinar, Mehmet Ilhan, Ali Fuat Kaan Gok, Mubariz Dadashov, Tufan Tukek
Orlistat is a pancreatic lipase inhibitor which is used to treat obesity. Due to the increasing prevalence of obesity, orlistat use is thought to rise progressively. We report an interesting case caused by orlistat use caught in the early stages of acute pancreatitis through imaging; in addition, the case had significantly elevated serum amylase levels. A 54-year-old male who had a history of orlistat treatment started 7 days before was admitted to the emergency department with complaints of abdominal pain, nausea and vomiting lasting for 24 h...
May 2015: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/25821626/limy-bile-syndrome-complicated-with-primary-hyperparathyroidism
#16
Yavuz Savas Koca, Tugba Koca, Ibrahim Barut
Limy bile is a relatively rare condition, in which a radiopaque material is visible in the gallbladder on plain radiography or computerized tomography. Cases of complicated hyperparathyroidism are extremely rare. We report a patient with right upper quadrant and epigastric pain and extremity weakness in whom abdominal tomography showed limy bile in the gallbladder and laboratory values showed high levels of serum calcium and parathormone.
2015: Case Reports in Surgery
https://www.readbyqxmd.com/read/25498850/milk-alkali-induced-pancreatitis-in-a-chronically-hypocalcemic-patient-with-digeorge-syndrome
#17
Nicholas J Daniel, Michael C Wadman, Chad E Branecki
BACKGROUND: Pancreatitis is a common diagnosis in the emergency department (ED), and milk-alkali syndrome (MAS) is an uncommon etiology for pancreatitis. MAS is caused by increased calcium and alkali ingestion, causing hypercalcemia accompanied by metabolic alkalosis and renal failure. Once considered rare, MAS is an increasingly common cause of hypercalcemia. Awareness of the resurgence of this syndrome is important for emergency physicians when recalling the causes of renal failure and pancreatitis...
March 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25399483/systemic-lupus-erythematosus-pancreatitis-an-uncommon-presentation-of-a-common-disease
#18
Eduardo A Rodriguez, Daniel A Sussman, Vanessa R Rodriguez
BACKGROUND: Acute pancreatitis is uncommon in systemic lupus erythematosus (SLE). When recognized early and properly treated with IV steroids and hydration, the course may be benign, as exemplified in the following report. CASE REPORT: A 21-year-old woman with history of SLE and stage IV lupus nephritis, was admitted to the Sergio Bernales Hospital ICU (Lima, Peru), complaining of worsening epigastric pain radiating to the back, and nausea and vomiting for 1 week...
2014: American Journal of Case Reports
https://www.readbyqxmd.com/read/25303492/from-hypocalcemia-to-hypercalcemia-an-unusual-clinical-presentation-of-a-patient-with-permanent-postsurgical-hypoparathyroidism
#19
Vishnu Sundaresh, Steven N Levine
CONTEXT: Hypercalcemia associated with lymphomas can be secondary to increased calcitriol [1,25(OH)2 vitamin D3], PTHrP, or osteolytic metastases. OBJECTIVE: A case of calcitriol-mediated hypercalcemia secondary to non-Hodgkin lymphoma in a patient with postsurgical hypoparathyroidism is presented. DESIGN AND SETTING: Single patient managed at a tertiary health care facility in the United States. PATIENT: A 55-year-old white woman had a total thyroidectomy and radioiodine ablation for a 3...
January 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25188737/hypervitaminosis-a-causing-hypercalcemia-in-cystic-fibrosis-case-report-and-focused-review
#20
REVIEW
Khalid H Safi, Amy G Filbrun, Samya Z Nasr
Hypercalcemia is a rare complication of hypervitaminosis A. We report a pediatric patient with cystic fibrosis (CF) and pancreatic insufficiency who was found to have hypervitaminosis A causing hypercalcemia, complicated by nephrocalcinosis and renal impairment. The patient is a 4-year-old girl with pancreatic-insufficient CF, gastroesophageal reflux, oral aversion, and failure to thrive requiring gastrostomy tube placement. She was prescribed Source CF vitamins, but rarely received the full dose, due to emesis and intolerance...
October 2014: Annals of the American Thoracic Society
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