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https://www.readbyqxmd.com/read/28816956/differential-diagnosis-of-posterior-fossa-brain-tumors-multiple-discriminant-analysis-of-tl-spect-and-fdg-pet
#1
Moritaka Yamauchi, Tomohisa Okada, Tsutomu Okada, Akira Yamamoto, Yasutaka Fushimi, Yoshiki Arakawa, Susumu Miyamoto, Kaori Togashi
This study investigated the combined capability of thallium-201 (Tl)-SPECT and fluorine-18-fluoro-deoxy-glucose (FDG)-PET for differential diagnosis of posterior fossa brain tumors using multiple discriminant analysis.This retrospective study was conducted under approval of the institutional review board. In the hospital information system, 27 patients with posterior fossa intra-axial tumor between January 2009 and June 2015 were enrolled and grouped as the following 7 entities: low grade glioma (LGG) 6, anaplastic astrocytoma (AA) 2, glioblastoma (GBM) 3, medulloblastoma (MB) 3, hemangioblastoma (HB) 6, metastatic tumor (Mets) 3, and malignant lymphoma (ML) 4...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28808684/constraining-the-rate-of-oceanic-deoxygenation-leading-up-to-a-cretaceous-oceanic-anoxic-event-oae-2-94-ma
#2
Chadlin M Ostrander, Jeremy D Owens, Sune G Nielsen
The rates of marine deoxygenation leading to Cretaceous Oceanic Anoxic Events are poorly recognized and constrained. If increases in primary productivity are the primary driver of these episodes, progressive oxygen loss from global waters should predate enhanced carbon burial in underlying sediments-the diagnostic Oceanic Anoxic Event relic. Thallium isotope analysis of organic-rich black shales from Demerara Rise across Oceanic Anoxic Event 2 reveals evidence of expanded sediment-water interface deoxygenation ~43 ± 11 thousand years before the globally recognized carbon cycle perturbation...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28802093/clinical-aspects-of-opium-adulterated-with-lead-in-iran-a-review
#3
Samira Alinejad, Jan Aaseth, Mohammad Abdollahi, Hossein Hassanian-Moghaddam, Omid Mehrpour
Adulteration of drugs with poisonous substances during production or consumption has caused numerous health problems. Among contaminants that have the potential of producing poisonous effects are the heavy metals lead, arsenic and thallium that make up an important group of toxic substances. The emergence of these new health problems related to opioid abuse has precipitated this MiniReview on the status of the most hazardous and common opioid adulterants. In fact, adulterated opium is a major public health problem and can threaten the health of users...
August 12, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28791581/phytoextraction-of-potentially-toxic-elements-by-six-tree-species-growing-on-hazardous-mining-sludge
#4
Mirosław Mleczek, Piotr Goliński, Magdalena Krzesłowska, Monika Gąsecka, Zuzanna Magdziak, Paweł Rutkowski, Sylwia Budzyńska, Bogusława Waliszewska, Tomisław Kozubik, Zbigniew Karolewski, Przemysław Niedzielski
The aim of the study was to compare the phytoextraction abilities of six tree species (Acer platanoides L., Acer pseudoplatanus L., Betula pendula Roth, Quercus robur L., Tilia cordata Miller, Ulmus laevis Pall.), cultivated on mining sludge contaminated with arsenic (As), cadmium (Cd), copper (Cu), lead (Pb), thallium (Tl), and zinc (Zn). All six tree species were able to survive on such an unpromising substrate. However, A. platanoides and T. cordata seedlings grown on the polluted substrate showed significantly lower biomass than control plants (55...
August 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28790781/to-study-the-efficacy-of-thallium-201-as-tumor-seeking-agent-and-to-study-its-role-in-therapeutic-response
#5
A V S Anil Kumar, P G Kumar, Sangeetha Sampath, V Suhag
BACKGROUND: Tumour seeking characteristics of TL-201 have been underutilized. The study was undertaken to evaluate the role of TL-201 scintigraphy in tumour imaging. METHODS: A total of 50 cases were studied over a period of 18 months (13 lymphomas, 11 breast carcinoma, 10 lung cancer, 6 of soft tissue sarcoma, 2 bone tumours and 4 cases each of thyroid and brain tumours). Thallium-201 chloride was injected IV in the dose range of 3-5 mCi. Imaging was done using Siemen's ECAM dual headed gamma camera...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28777540/determination-of-the-isotopic-composition-of-iridium-using-multicollector-icpms
#6
Zuhao Zhu, Juris Meija, Airong Zheng, Zoltan Mester, Lu Yang
Like many other elements, iridium is lacking a calibrated, SI traceable isotope ratio measurement. In this study, we have undertaken absolute isotope amount ratio measurements of iridium by multicollector inductively coupled plasma mass spectrometry (MC-ICPMS) using a state-of-the-art regression model to correct for the instrumental fractionation (mass bias) of isotope ratios using both NIST SRM 997 isotopic thallium and NIST SRM 989 isotopic rhenium as primary calibrators. The optimized regression mass bias correction model is based on incrementally increasing plasma power and short (10-30 min) measurement sessions...
August 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28766107/examining-of-thallium-in-cigarette-smokers
#7
Amir Ghaderi, Payam NasehGhafoori, Morad Rasouli-Azad, Mojtaba Sehat, Fateme Mehrzad, Mina Nekuei, Jan Aaseth, Hamid Reza Banafshe, Omid Mehrpour
Smoking is one of the sources of thallium which is considered as a toxic heavy metal. The aim of this study was to determine urinary thallium levels and related variables in smokers, compared to a control group. The study was conducted on 56 participants who had smoked continuously during the year before they were referred to Kashan Smoking Cessation Clinic. Fifty-three nonsmokers who were family members or friends of the smokers were selected as the control group. Urinary thallium was measured in both groups (n = 109) using atomic absorption spectrophotometry...
August 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28761262/acute-alopecia-evidence-to-thallium-poisoning
#8
Subramanian Senthilkumaran, Namasivayam Balamurugan, Narendra Nath Jena, Ritesh G Menezes, Ponniah Thirumalaikolundusubramanian
Thallium is a toxic heavy metal often involved in criminal poisonings and occasionally in accidental poisoning. Here, we report a case of acute, nonintentional thallium poisoning due to thallium-contaminated alternative medicine for its rarity and to create awareness about the combination of rapid, diffuse alopecia with neurologic and gastrointestinal symptoms among practitioners, professionals, public, and policymakers.
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28755544/highly-efficient-removal-of-trace-thallium-from-contaminated-source-waters-with-ferrate-role-of-in-situ-formed-ferric-nanoparticle
#9
Yulei Liu, Lu Wang, Xianshi Wang, Zhuangsong Huang, Chengbiao Xu, Tao Yang, Xiaodan Zhao, Jingyao Qi, Jun Ma
Thallium (Tl) is highly toxic to mammals and relevant pollution cases are increasing world-widely. Convenient and efficient method for the removal of trace Tl from contaminated source water is imperative. Here, the removal of trace Tl by K2FeO4 [Fe(VI)] was investigated for the first time, with the exploration of reaction mechanisms. Six different types of water treatment agents (powdered activated carbon, Al2(SO4)3, FeCl3, δ-MnO2, MnO2 nano-particles, and K2FeO4) were used for the removal of Tl in spiked river water, and K2FeO4 showed excellent removal performance...
July 22, 2017: Water Research
https://www.readbyqxmd.com/read/28732992/the-effects-of-altering-reaction-conditions-in-green-sonochemical-synthesis-of-a-thallium-i-coordination-polymer-and-in-achieving-to-different-morphologies-of-thallium-iii-oxide-nanostructures-via-solid-state-process
#10
Zeinab Hazrati, Kamran Akhbari, Anukorn Phuruangrat
In order to studies the effects of solvent and concentration of initial reagents on formation of [Tl(μ4-AB)]n (1), [HAB=4-aminobenzoic acid] coordination polymer, some experiments were designed and four samples of 1 were synthesized by sonochemical process. High concentration of initial reagents resulted in formation of compound 1 microrods. With low concentration of initial reagents, various morphologies of 1 were obtained. These four samples had been used as new precursors for preparation of thallium(III) oxide nanostructures via solid-state thermal decomposition process...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28727988/environmental-exposures-and-pediatric-kidney-function-and-disease-a-systematic-review
#11
REVIEW
Laura Y Zheng, Alison P Sanders, Jeffrey M Saland, Robert O Wright, Manish Arora
BACKGROUND: Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. METHODS: We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. RESULTS: We found 50 studies that met the search criteria and were included in this systematic review...
July 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28716727/systematic-review-and-meta-analysis-links-autism-and-toxic-metals-and-highlights-the-impact-of-country-development-status-higher-blood-and-erythrocyte-levels-for-mercury-and-lead-and-higher-hair-antimony-cadmium-lead-and-mercury
#12
REVIEW
Amene Saghazadeh, Nima Rezaei
BACKGROUND: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder that affects cognitive and higher cognitive functions. Increasing prevalence of ASD and high rates of related comorbidities has caused serious health loss and placed an onerous burden on the supporting families, caregivers, and health care services. Heavy metals are among environmental factors that may contribute to ASD. However, due to inconsistencies across studies, it is still hard to explain the association between ASD and toxic metals...
July 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28703433/accessing-low-valent-inorganic-cations-by-using-an-extremely-bulky-n-heterocyclic-carbene
#13
Matthew M D Roy, Paul A Lummis, Michael J Ferguson, Robert McDonald, Eric Rivard
The extremely bulky N-heterocyclic carbene (NHC), ITr (ITr=[(HCNCPh3 )2 C:]) featuring sterically shielding umbrella-shaped trityl (CPh3 ) substituents was prepared. This NHC features the highest percent buried volume (%Vbur ) to date, and was used to form a thermally stable quasi one-coordinate thallium(I) cation [ITr-Tl](+) . This Tl(I) adduct and the corresponding lithium complex [ITr⋅Li(OEt2 )](+) are versatile "all-in-one" transmetalation/ligation reagents for preparing low-coordinate inorganic species inaccessible by pre-existing routes...
July 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28697192/a-prototype-pet-spect-x-rays-scanner-dedicated-for-whole-body-small-animal-studies
#14
Maritina Rouchota, Maria Georgiou, Eleftherios Fysikopoulos, Eirini Fragogeorgi, Konstantinos Mikropoulos, Panagiotis Papadimitroulas, George Kagadis, George Loudos
OBJECTIVE: To present a prototype tri-modal imaging system, consisting of a single photon emission computed tomography (SPET), a positron emission tomography (PET), and a computed tomography (CT) subsystem, evaluated in planar mode. MATERIALS AND METHODS: The subsystems are mounted on a rotating gantry, so as to be able to allow tomographic imaging in the future. The system, designed and constructed by our group, allows whole body mouse imaging of competent performance and is currently, to the best of our knowledge, unequaled in a national and regional level...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28693110/potential-effects-of-brevetoxins-and-toxic-elements-on-various-health-variables-in-kemp-s-ridley-lepidochelys-kempii-and-green-chelonia-mydas-sea-turtles-after-a-red-tide-bloom-event
#15
Justin R Perrault, Nicole I Stacy, Andreas F Lehner, Cody R Mott, Sarah Hirsch, Jonathan C Gorham, John P Buchweitz, Michael J Bresette, Catherine J Walsh
Natural biotoxins and anthropogenic toxicants pose a significant risk to sea turtle health. Documented effects of contaminants include potential disease progression and adverse impacts on development, immune function, and survival in these imperiled species. The shallow seagrass habitats of Florida's northwest coast (Big Bend) serve as an important developmental habitat for Kemp's ridley (Lepidochelys kempii) and green (Chelonia mydas) sea turtles; however, few studies have been conducted in this area. Our objectives were (1) to evaluate plasma analytes (mass, minimum straight carapace length, body condition index [BCI], fibropapilloma tumor score, lysozyme, superoxide dismutase, reactive oxygen/nitrogen species, plasma protein electrophoresis, cholesterol, and total solids) in Kemp's ridleys and green turtles and their correlation to brevetoxins that were released from a red tide bloom event from July-October 2014 in the Gulf of Mexico near Florida's Big Bend, and (2) to analyze red blood cells in Kemp's ridleys and green turtles for toxic elements (arsenic, cadmium, lead, mercury, selenium, thallium) with correlation to the measured plasma analytes...
July 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28692492/criteria-for-the-addition-of-prone-imaging-to-myocardial-perfusion-single-photon-emission-computed-tomography-for-inferior-wall
#16
Koji Nakaya, Masahisa Onoguchi, Yoshihiro Nishimura, Keisuke Kiso, Hideki Otsuka, Yoshifumi Nouno, Takayuki Shibutani, Eisuke Yasuda
OBJECTIVE: Myocardial perfusion single-photon emission computed tomography (SPECT) is occasionally suspected to generate images that represent either ischemia or infarction for the inferior wall [right coronary artery (RCA) disease] or attenuation artifacts because of the diaphragm. We often encounter this. The application of prone imaging is advantageous in the differentiation of RCA disease because of attenuation artifacts. If decreased accumulation of radioisotopes is observed at the site with either RCA disease or attenuation artifacts, then a criterion that enables the addition of prone imaging should be implemented...
July 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28689732/applying-preoperative-dipyridamole-thallium-201-scintigraphy-for-preventing-cardiac-mortality-and-complications-for-patients-with-secondary-hyperparathyroidism-undergoing-parathyroidectomy
#17
Shih-Min Yin, Fong-Fu Chou, Shao-Chun Wu, Shun-Yu Chi
BACKGROUND: To evaluate the value of preoperative dipyridamole thallium-201 scintigraphy for reducing cardiovascular complication in secondary hyperparathyroidism (SHPTH) patients. METHODS: Thallium scintigraphy was arranged for all dialysis patients who underwent parathyroidectomy from Jan 2011 to July 2015. Management of defects on thallium scintigraphy included cardiac catheterization and ultrasonography. Analysis includes 30-day mortality, morbidity and the predicting factors for thallium scintigraphy defect...
July 6, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28678196/substituent-effects-on-the-stability-of-thallium-and-phosphorus-triple-bonds-a-density-functional-study
#18
Jia-Syun Lu, Ming-Chung Yang, Ming-Der Su
Three computational methods (M06-2X/Def2-TZVP, B3PW91/Def2-TZVP and B3LYP/LANL2DZ+dp) were used to study the effect of substitution on the potential energy surfaces of RTl≡PR (R = F, OH, H, CH₃, SiH₃, SiMe(SitBu₃)₂, SiiPrDis₂, Tbt (=C₆H₂-2,4,6-(CH(SiMe₃)₂)₃), and Ar* (=C₆H₃-2,6-(C₆H₂-2, 4,6-i-Pr₃)₂)). The theoretical results show that these triply bonded RTl≡PR compounds have a preference for a bent geometry (i.e., ∠R⎼Tl⎼P ≈ 180° and ∠Tl⎼P⎼R ≈ 120°). Two valence bond models are used to interpret the bonding character of the Tl≡P triple bond...
July 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28664481/comparison-of-conventional-and-cadmium-zinc-telluride-single-photon-emission-computed-tomography-for-analysis-of-thallium-201-myocardial-perfusion-imaging-an-exploratory-study-in-normal-databases-for-different-ethnicities
#19
Masaru Ishihara, Masahisa Onoguchi, Yasuyo Taniguchi, Takayuki Shibutani
The aim of this study was to clarify the differences in thallium-201-chloride (thallium-201) myocardial perfusion imaging (MPI) scans evaluated by conventional anger-type single-photon emission computed tomography (conventional SPECT) versus cadmium-zinc-telluride SPECT (CZT SPECT) imaging in normal databases for different ethnic groups. MPI scans from 81 consecutive Japanese patients were examined using conventional SPECT and CZT SPECT and analyzed with the pre-installed quantitative perfusion SPECT (QPS) software...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28631939/a-high-throughput-screening-assay-for-nkcc1-cotransporter-using-nonradioactive-rubidium-flux-technology
#20
Sikander Gill, Rajwant Gill, Yang Wen, Thilo Enderle, Doris Roth, Dong Liang
A high-throughput screening (HTS) assay was developed for cotransporter, NKCC1, which is a potential target for the treatment of diverse disorders. This nonradioactive rubidium flux assay coupled with ion channel reader series provides a working screen for this target expressed in human embryonic kidney (HEK) cell line. An eightfold window of detection was achieved with the optimized assay. This new functional assay offered a robust working model for NKCC1 in determining reliable and concordant rank orders of the test compounds supporting its sensitivity and specificity...
May 2017: Assay and Drug Development Technologies
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