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https://www.readbyqxmd.com/read/28928986/cholinergic-potentiation-of-restoration-of-visual-function-after-optic-nerve-damage-in-rats
#1
Mira Chamoun, Elena G Sergeeva, Petra Henrich-Noack, Shaobo Jia, Lisa Grigartzik, Jing Ma, Qing You, Frédéric Huppé-Gourgues, Bernhard A Sabel, Elvire Vaucher
Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28918289/effective-removal-of-trace-thallium-from-surface-water-by-nanosized-manganese-dioxide-enhanced-quartz-sand-filtration
#2
Xiaoliu Huangfu, Chengxue Ma, Jun Ma, Qiang He, Chun Yang, Jian Zhou, Jin Jiang, Yaan Wang
Thallium (Tl) has drawn wide concern due to its high toxicity even at extremely low concentrations, as well as its tendency for significant accumulation in the human body and other organisms. The need to develop effective strategies for trace Tl removal from drinking water is urgent. In this study, the removal of trace Tl (0.5 μg L(-1)) by conventional quartz sand filtration enhanced by nanosized manganese dioxide (nMnO2) has been investigated using typical surface water obtained from northeast China. The results indicate that nMnO2 enhanced quartz sand filtration could remove trace Tl(I) and Tl(III) efficiently through the adsorption of Tl onto nMnO2 added to a water matrix and onto nMnO2 attached on quartz sand surfaces...
September 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28913548/changes-in-histopathology-enzyme-activities-and-the-expression-of-relevant-genes-in-zebrafish-danio-rerio-following-long-term-exposure-to-environmental-levels-of-thallium
#3
Li-Ping Hou, Yang Yang, Hu Shu, Guang-Guo Ying, Jian-Liang Zhao, Yi-Bing Chen, Yong-Heng Chen, Gui-Zhen Fang, Xin Li, Ji-Sheng Liu
Thallium is a rare-earth element, but widely distributed in water environments, posing a potential risk to our health. This study was designed to investigate the chronic effects of thallium based on physiological responses, gene expression, and changes in the activity of relevant enzymes in adult zebra fish exposed to thallium at low doses. The endpoints assessed include mRNA expression of metallothionein (MT)2 and heat shock protein HSP70; enzymatic activities of superoxide dismutase (SOD) and Na(+)/K(+)-ATPase; and the histopathology of gill, gonad, and liver tissues...
September 14, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28889276/thallium-toxicity-general-issues-neurological-symptoms-and-neurotoxic-mechanisms
#4
Laura Osorio-Rico, Abel Santamaria, Sonia Galván-Arzate
Thallium (Tl(+)) is a ubiquitous natural trace metal considered as the most toxic among heavy metals. The ionic ratio of Tl(+) is similar to that of potassium (K(+)), therefore accounting for the replacement of the latter during enzymatic reactions. The principal organelle damaged after Tl(+) exposure is mitochondria. Studies on the mechanisms of Tl(+) include intrinsic pathways altered and changes in antiapoptotic and proapoptotic proteins, cytochrome c, and caspases. Oxidative damage pathways increase after Tl(+) exposure to produce reactive oxygen species (ROS), changes in physical properties of the cell membrane caused by lipid peroxidation, and concomitant activation of antioxidant mechanisms...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28887631/the-efficient-removal-of-thallium-from-sintering-flue-gas-desulfurization-wastewater-in-ferrous-metallurgy-using-emulsion-liquid-membrane
#5
Li Yang, Jiangping Xiao, Yi Shen, Xian Liu, Wensong Li, Weiyan Wang, Yunquan Yang
The removal of thallium ions in flue gas desulfurization wastewater from ferrous metallurgic industry was studied by emulsion liquid membrane (ELM) method using 2-ethylhexyl phosphoric acid-2-ethylhexyl ester (P507) as carrier, aviation kerosene (AK) as organic solvent, polyisobutylene succinimide (T154) as surfactant, polyisobutylene (PIB) as additive, and sulfuric acid as internal reagent. Some important influence parameters such as concentrations of carrier, surfactant and stripping agent, agitation speed, extraction time, volume ratios of feed solution to emulsion phase and internal phase to membrane phase, and their effects on the removal efficiency of Tl in the ELM process were investigated and optimized...
September 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28882594/terbinafine-is-a-novel-and-selective-activator-of-the-two-pore-domain-potassium-channel-task3
#6
Paul D Wright, Emma L Veale, David McCoull, David C Tickle, Jonathan M Large, Emma Ococks, Gemma Gothard, Catherine Kettleborough, Alistair Mathie, Jeffrey Jerman
Two-pore domain potassium channels (K2Ps) are characterized by their four transmembrane domain and two-pore topology. They carry background (or leak) potassium current in a variety of cell types. Despite a number of important roles there is currently a lack of pharmacological tools with which to further probe K2P function. We have developed a cell-based thallium flux assay, using baculovirus delivered TASK3 (TWIK-related acid-sensitive K(+) channel 3, KCNK9, K2P9.1) with the aim of identifying novel, selective TASK3 activators...
September 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28879543/apex-predatory-mammals-as-bioindicator-species-in-environmental-monitoring-of-elements-in-dinaric-alps-croatia
#7
Maja Lazarus, Ankica Sekovanić, Tatjana Orct, Slaven Reljić, Josip Kusak, Jasna Jurasović, Đuro Huber
Tissue element investigations of apex terrestrial mammals are very scarce in Europe. We quantified 16 essential and nonessential elements in the kidney cortex, liver, and muscle tissue of 467 brown bears (Ursus arctos), 125 gray wolves (Canis lupus), one Eurasian lynx (Lynx lynx), and three golden jackals (Canis aureus) from Croatia by inductively coupled plasma mass spectrometry (ICP-MS). Renal cadmium (0.6% of animals) and lead (1%) and hepatic lead (5%) were found in toxicologically relevant levels for mammals only in bears, while the other elements were within normal range...
September 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28879528/effects-of-chronic-kidney-disease-on-myocardial-washout-rate-of-thallium-201-in-patients-with-normal-myocardial-perfusion-on-single-photon-emission-computed-tomography
#8
Satoshi Kurisu, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
BACKGROUND: Myocardial perfusion single photon emission computed tomography (SPECT) is often performed even in patients with chronic kidney disease (CKD). We assessed the effects of CKD on myocardial washout rate (WR) of thallium (Tl)-201 in patients with normal myocardial perfusion on SPECT. METHODS: Two hundred and fifty-six patients with normal myocardial perfusion were enrolled in this study. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1...
September 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28866748/early-response-of-glutathione-and-thioredoxin-dependent-antioxidant-defense-systems-to-tl-i-and-tl-iii-mediated-oxidative-stress-in-adherent-pheochromocytoma-pc12adh-cells
#9
Lis C Puga Molina, Damiana M Salvatierra Fréchou, Sandra V Verstraeten
Thallium (Tl) is a toxic heavy metal that causes oxidative stress both in vitro and in vivo. In this work, we evaluated the production of oxygen (ROS)- and nitrogen (RNS)-reactive species in adherent PC12 (PC12adh) cells exposed for 0.5-6 h to Tl(I) or Tl(III) (10-100 µM). In this system, Tl(I) induced mostly H2O2 generation while Tl(III) induced H2O2 and ONOO(·-) generation. Both cations enhanced iNOS expression and activity, and decreased CuZnSOD expression but without affecting its activity. Tl(I) increased MnSOD expression and activity but Tl(III) decreased them...
September 2, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28833820/identification-of-complexes-involving-tl-i-and-tl-iii-with-edta-and-dtpa-ligands-by-esi-ms
#10
Joanna Zembrzuska, Bozena Karbowska
RATIONALE: Thallium is considered as an environmental threat, however its hazardous properties depend on its oxidation state. Tl(III) is approx. 1000-times more toxic compared to Tl(I), therefore identification of each species is essential in order to properly evaluate the associated health hazard. ESI-MS allows determination of speciation in solution due to its soft mode of ionization while selective complexation with ligands allows to distinguish the Tl species. Selective complexation of Tl(I) and Tl(III) ions requires the use of two selective complexing agents and selection of appropriate conditions for this process...
August 21, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28816956/differential-diagnosis-of-posterior-fossa-brain-tumors-multiple-discriminant-analysis-of-tl-spect-and-fdg-pet
#11
Moritaka Yamauchi, Tomohisa Okada, Tsutomu Okada, Akira Yamamoto, Yasutaka Fushimi, Yoshiki Arakawa, Susumu Miyamoto, Kaori Togashi
This study investigated the combined capability of thallium-201 (Tl)-SPECT and fluorine-18-fluoro-deoxy-glucose (FDG)-PET for differential diagnosis of posterior fossa brain tumors using multiple discriminant analysis.This retrospective study was conducted under approval of the institutional review board. In the hospital information system, 27 patients with posterior fossa intra-axial tumor between January 2009 and June 2015 were enrolled and grouped as the following 7 entities: low grade glioma (LGG) 6, anaplastic astrocytoma (AA) 2, glioblastoma (GBM) 3, medulloblastoma (MB) 3, hemangioblastoma (HB) 6, metastatic tumor (Mets) 3, and malignant lymphoma (ML) 4...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28808684/constraining-the-rate-of-oceanic-deoxygenation-leading-up-to-a-cretaceous-oceanic-anoxic-event-oae-2-94-ma
#12
Chadlin M Ostrander, Jeremy D Owens, Sune G Nielsen
The rates of marine deoxygenation leading to Cretaceous Oceanic Anoxic Events are poorly recognized and constrained. If increases in primary productivity are the primary driver of these episodes, progressive oxygen loss from global waters should predate enhanced carbon burial in underlying sediments-the diagnostic Oceanic Anoxic Event relic. Thallium isotope analysis of organic-rich black shales from Demerara Rise across Oceanic Anoxic Event 2 reveals evidence of expanded sediment-water interface deoxygenation ~43 ± 11 thousand years before the globally recognized carbon cycle perturbation...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28802093/clinical-aspects-of-opium-adulterated-with-lead-in-iran-a-review
#13
Samira Alinejad, Jan Aaseth, Mohammad Abdollahi, Hossein Hassanian-Moghaddam, Omid Mehrpour
Adulteration of drugs with poisonous substances during production or consumption has caused numerous health problems. Among contaminants that have the potential of producing poisonous effects are the heavy metals lead, arsenic and thallium that make up an important group of toxic substances. The emergence of these new health problems related to opioid abuse has precipitated this MiniReview on the status of the most hazardous and common opioid adulterants. In fact, adulterated opium is a major public health problem and can threaten the health of users...
August 12, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28791581/phytoextraction-of-potentially-toxic-elements-by-six-tree-species-growing-on-hazardous-mining-sludge
#14
Mirosław Mleczek, Piotr Goliński, Magdalena Krzesłowska, Monika Gąsecka, Zuzanna Magdziak, Paweł Rutkowski, Sylwia Budzyńska, Bogusława Waliszewska, Tomisław Kozubik, Zbigniew Karolewski, Przemysław Niedzielski
The aim of the study was to compare the phytoextraction abilities of six tree species (Acer platanoides L., Acer pseudoplatanus L., Betula pendula Roth, Quercus robur L., Tilia cordata Miller, Ulmus laevis Pall.), cultivated on mining sludge contaminated with arsenic (As), cadmium (Cd), copper (Cu), lead (Pb), thallium (Tl), and zinc (Zn). All six tree species were able to survive on such an unpromising substrate. However, A. platanoides and T. cordata seedlings grown on the polluted substrate showed significantly lower biomass than control plants (55...
August 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28790781/to-study-the-efficacy-of-thallium-201-as-tumor-seeking-agent-and-to-study-its-role-in-therapeutic-response
#15
A V S Anil Kumar, P G Kumar, Sangeetha Sampath, V Suhag
BACKGROUND: Tumour seeking characteristics of TL-201 have been underutilized. The study was undertaken to evaluate the role of TL-201 scintigraphy in tumour imaging. METHODS: A total of 50 cases were studied over a period of 18 months (13 lymphomas, 11 breast carcinoma, 10 lung cancer, 6 of soft tissue sarcoma, 2 bone tumours and 4 cases each of thyroid and brain tumours). Thallium-201 chloride was injected IV in the dose range of 3-5 mCi. Imaging was done using Siemen's ECAM dual headed gamma camera...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28777540/determination-of-the-isotopic-composition-of-iridium-using-multicollector-icpms
#16
Zuhao Zhu, Juris Meija, Airong Zheng, Zoltan Mester, Lu Yang
Like many other elements, iridium is lacking a calibrated, SI traceable isotope ratio measurement. In this study, we have undertaken absolute isotope amount ratio measurements of iridium by multicollector inductively coupled plasma mass spectrometry (MC-ICPMS) using a state-of-the-art regression model to correct for the instrumental fractionation (mass bias) of isotope ratios using both NIST SRM 997 isotopic thallium and NIST SRM 989 isotopic rhenium as primary calibrators. The optimized regression mass bias correction model is based on incrementally increasing plasma power and short (10-30 min) measurement sessions...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28766107/examining-of-thallium-in-cigarette-smokers
#17
Amir Ghaderi, Payam NasehGhafoori, Morad Rasouli-Azad, Mojtaba Sehat, Fateme Mehrzad, Mina Nekuei, Jan Aaseth, Hamid Reza Banafshe, Omid Mehrpour
Smoking is one of the sources of thallium which is considered as a toxic heavy metal. The aim of this study was to determine urinary thallium levels and related variables in smokers, compared to a control group. The study was conducted on 56 participants who had smoked continuously during the year before they were referred to Kashan Smoking Cessation Clinic. Fifty-three nonsmokers who were family members or friends of the smokers were selected as the control group. Urinary thallium was measured in both groups (n = 109) using atomic absorption spectrophotometry...
August 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28761262/acute-alopecia-evidence-to-thallium-poisoning
#18
Subramanian Senthilkumaran, Namasivayam Balamurugan, Narendra Nath Jena, Ritesh G Menezes, Ponniah Thirumalaikolundusubramanian
Thallium is a toxic heavy metal often involved in criminal poisonings and occasionally in accidental poisoning. Here, we report a case of acute, nonintentional thallium poisoning due to thallium-contaminated alternative medicine for its rarity and to create awareness about the combination of rapid, diffuse alopecia with neurologic and gastrointestinal symptoms among practitioners, professionals, public, and policymakers.
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28755544/highly-efficient-removal-of-trace-thallium-from-contaminated-source-waters-with-ferrate-role-of-in-situ-formed-ferric-nanoparticle
#19
Yulei Liu, Lu Wang, Xianshi Wang, Zhuangsong Huang, Chengbiao Xu, Tao Yang, Xiaodan Zhao, Jingyao Qi, Jun Ma
Thallium (Tl) is highly toxic to mammals and relevant pollution cases are increasing world-widely. Convenient and efficient method for the removal of trace Tl from contaminated source water is imperative. Here, the removal of trace Tl by K2FeO4 [Fe(VI)] was investigated for the first time, with the exploration of reaction mechanisms. Six different types of water treatment agents (powdered activated carbon, Al2(SO4)3, FeCl3, δ-MnO2, MnO2 nano-particles, and K2FeO4) were used for the removal of Tl in spiked river water, and K2FeO4 showed excellent removal performance...
July 22, 2017: Water Research
https://www.readbyqxmd.com/read/28732992/the-effects-of-altering-reaction-conditions-in-green-sonochemical-synthesis-of-a-thallium-i-coordination-polymer-and-in-achieving-to-different-morphologies-of-thallium-iii-oxide-nanostructures-via-solid-state-process
#20
Zeinab Hazrati, Kamran Akhbari, Anukorn Phuruangrat
In order to studies the effects of solvent and concentration of initial reagents on formation of [Tl(μ4-AB)]n (1), [HAB=4-aminobenzoic acid] coordination polymer, some experiments were designed and four samples of 1 were synthesized by sonochemical process. High concentration of initial reagents resulted in formation of compound 1 microrods. With low concentration of initial reagents, various morphologies of 1 were obtained. These four samples had been used as new precursors for preparation of thallium(III) oxide nanostructures via solid-state thermal decomposition process...
November 2017: Ultrasonics Sonochemistry
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