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Technetium 99m

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https://www.readbyqxmd.com/read/28723715/novel-weight-based-dose-threshold-for-18f-naf-pet-ct-imaging-using-advanced-pet-ct-systems-a-potential-tool-for-reducing-radiation-burden
#1
Fahad Marafi, Abdulreda Esmail, Rashid Rasheed, Fareeda Alkandari, Sharjeel Usmani
BACKGROUND: Fluorine-18-sodium fluoride (F-NaF) PET/CT is an important tool for detecting and evaluating metastatic bone cancer. Besides traditional dose metrics, recent methods such as real-time dose mapping, dose calculation from DICOM information, and their relevance to entrance skin exposure are currently in use to reduce the radiation burden. In this study, we have analyzed the data of 1062 patients retrospectively to evaluate patterns of absorbed dose for institutional weight-based dose protocol as compared with fixed dose method guidelines of Society of Nuclear Medicine and Molecular Imaging (SNMMI)...
July 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28717076/increase-in-the-regional-cerebral-blood-flow-following-waon-therapy-in-patients-with-chronic-fatigue-syndrome-a-pilot-study
#2
Takao Munemoto, Yuji Soejima, Akinori Masuda, Yoshiaki Nakabeppu, Chuwa Tei
Objective Chronic fatigue syndrome (CFS) is a complex disorder, with no consensus on therapeutic options. However, Waon therapy has been reported to be an effective treatment. The purpose of this study was to evaluate changes in the cerebral blood flow (CBF) before and after Waon therapy in CFS patients and to investigate the correlation between such changes and the therapeutic efficacy of Waon therapy. Methods Eleven patients (2 men and 9 women, mean age 27 years old) diagnosed with CFS participated in the study...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715874/detection-of-bacterial-infection-by-a-technetium-99m-labeled-peptidoglycan-aptamer
#3
Iêda Mendes Ferreira, Camila Maria de Sousa Lacerda, Sara Roberta Dos Santos, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Nuclear medicine clinicians are still waiting for the optimal scintigraphic imaging agents capable of distinguishing between infection and inflammation, and between fungal and bacterial infections. Aptamers have several properties that make them suitable for molecular imaging. In the present study, a peptidoglycan aptamer (Antibac1) was labeled with (99m)Tc and evaluated by biodistribution studies and scintigraphic imaging in infection-bearing mice. Labeling with (99m)Tc was performed by the direct method and the complex stability was evaluated in saline, plasma and in the molar excess of cysteine...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28711547/interobserver-variability-for-interpretation-of-dmsa-scans-in-the-rivur-trial
#4
Tej K Mattoo, Steven J Skoog, Lisa Gravens-Mueller, Russell W Chesney, Alejandro Hoberman, Ranjiv Mathews, Marva Moxey-Mims, Anastasia Ivanova, Saul P Greenfield, Myra A Carpenter
INTRODUCTION: Technetium-99m dimercaptosuccinic acid (DMSA) renal scans are used in the diagnosis of renal scarring. In the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial that randomized 607 children, DMSA renal scans were used for evaluating the presence and the severity of renal scarring. OBJECTIVE: The aim was to determine interobserver variability in reporting of DMSA renal scans in the RIVUR trial. STUDY DESIGN: We compared DMSA renal scan reports for renal scarring and acute pyelonephritis from all non-reference local radiologists (ALRs) at study sites with adjudicated as well as non-adjudicated reports from two reference radiologists (RRs) of the RIVUR trial...
June 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28702615/thiourea-derivatives-as-chelating-agents-for-bioconjugation-of-rhenium-and-technetium
#5
J D Castillo Gomez, A Hagenbach, U I M Gerling-Driessen, B Koksch, N Beindorff, W Brenner, U Abram
Potential tetradentate thiocarbamoylbenzamidine derivatives H4L have been synthesized from the corresponding benzimidoyl chlorides and triglycine. They are suitable chelating agents for the oxidotechnetium(v) and oxidorhenium(v) cores and form stable, neutral [MO(HL)] complexes with an equatorial SN3 coordination sphere and an additional, uncoordinated carboxylic group, which can be used for bioconjugation. Representatives of the rhenium and (99)Tc products have been isolated and analyzed with spectroscopic methods and X-ray diffraction...
July 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28697191/an-innovative-method-for-precise-lymph-node-detection-before-surgical-treatment
#6
Milovan Matovic, Dalibor Nikolic, Nenad Filipovic, Dongfang Chen, Marija Jeremic, Slobodan M Jankovic, Srdjan Ninkovic, Aleksandar Cvetkovic, Marina Vlajkovic, Ana Rankovic
OBJECTIVE: To describe a new method of 3D interactive modeling which integrates images obtained by separate SPET and multi slice computed tomography (MSCT) modalities using an original software in order to better localize SNL in BC patients. SUBJECTS AND METHODS: We used technetium-99m-colloid rhenium sulphate for identifying SNL in seven patients with BC. Markers were made of lead pearls wrapped with cotton wool soaked in (99m)Tc-pertechnetate and placed on the skin of the patients forming of a triangle...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28694567/immunohistochemistry-in-ureteropelvic-junction-obstruction-and-its-correlation-to-postoperative-outcome
#7
Anusiri Inugala, Ramesh Kota Reddy, Bhuvaneshwar Nadipalli Rao, Sreenivas P Reddy, Radhika Othuluru, Lavanya Kanniyan, Nagarjuna Kumbha, Srinivas Srirampur
AIM: To investigate the correlation between the status of interstitial cells of Cajal (ICC) in ureteropelvic junction (UPJ) and the resected ureteric margin and the postoperative outcome of Anderson-Hynes pyeloplasty in UPJ obstruction (UPJO) and to compare the ICC in the UPJ and the resected margin of the normal ureter. MATERIALS AND METHODS: An observational study was conducted over a period of 2 years at the Department of Pediatric Surgery at Niloufer Institute of Women and Child Health...
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28692495/the-clinical-significance-of-technetium-99m-methylene-diphosphonate-bone-scintigraphy-findings-in-patients-with-rhabdomyolysis
#8
Jeong Won Lee, Eun-Young Lee, Sae-Yong Hong, Ik Dong Yoo, Sang Mi Lee
OBJECTIVE: This study evaluated the relationship between bone scintigraphy finding and clinical factors and assessed the prognostic value of bone scintigraphy finding in patients with rhabdomyolysis. PATIENTS AND METHODS: We retrospectively enrolled 143 patients with rhabdomyolysis who had undergone bone scintigraphy. Bone scintigraphy was classified into three groups: no or equivocal soft tissue uptake, a localized uptake, and a diffuse uptake. The relationship of bone scintigraphy findings with clinical factors was evaluated...
July 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28692493/the-application-of-technetium-99m-red-blood-cell-scintigraphy-in-the-diagnosis-of-orbital-cavernous-hemangioma
#9
Hua Dong, Zuncheng Zhang, Yongtao Guo, Hong Zhang, Wengui Xu
OBJECTIVE: The purpose of this study was to evaluate the clinical value of technetium-99m-red blood cell (Tc-RBC) scintigraphy in the diagnosis of orbital cavernous hemangioma (OCH). PATIENTS AND METHODS: Forty-one patients with pathologically confirmed orbital mass, of which 10 were OCH, underwent Tc-RBC scintigraphy in this study. The scanning procedure included an initial perfusion phase, followed by an early and a delayed blood pool phase. All patients underwent ultrasonography and computed tomography (CT), and 15 patients also underwent MRI...
July 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28690676/radioguided-localisation-of-non-palpable-lesions-of-the-breast-in-costa-rica-review-of-results-of-our-first-800-patients-in-private-practice
#10
REVIEW
Marisel Aguilar, Sabrina Alfaro, Ricardo Aguilar
BACKGROUND: Surgical treatment of non-palpable breast lesions is controversial. At the European Institute of Oncology in Milan, Italy, Prof Umberto Veronesi introduced a new technique called the radioguided occult lesion localisation (ROLL) in 1996 to replace conventional methods and their disadvantages (Zurrida S, Galimberti V, and Monti S et al (1998) Radioguided localization of occult breast lesionsBreast7 11-13 https://doi.org/10.1016/S0960-9776(98)90044-3). Given the success experienced in that institution, the method became the technique of choice for the early diagnosis of breast cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28689886/use-of-radiotracer-labeling-of-pulmonary-nodules-to-facilitate-excisional-biopsy-and-metastasectomy-in-children-with-solid-tumors
#11
Stephanie F Polites, Aodhnait S Fahy, William A Sunnock, Donald D Potter, Denise B Klinkner, Christopher R Moir, K Robert Shen, Michael B Ishitani
PURPOSE: Excision of suspected pulmonary metastases in children is challenging in the setting of multiple nodules or nodules that are small, deep, or soft. This study describes preoperative technetium macro-aggregated albumin (Tc 99m MAA) localization of pulmonary lesions to aid in intraoperative identification and resection. METHODS: Patients with past or present pediatric solid tumors who underwent resection of pulmonary nodules following CT-guided Tc 99m MAA labeling were identified...
June 27, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28685802/hemorrhagic-meckel-s-diverticulum-interest-of-the-digestive-pertechnetate-scintigraphy
#12
Aida Mhiri, Ihsen Slim, Faouzi Ben Slimène
Meckel's diverticulum is the most prevalent congenital abnormality of the gastrointestinal tract. Clinical symptoms can result in pain, bleeding and perforation caused by peptic ulceration. Among all imaging modalities, Tc-99m pertechnetate scintigraphy is the most sensitive method for Meckel's diverticulum diagnosis, but only mentioned in a few publications. We report the case of a young child with rectal bleeding related hemorrhagic Meckel's diverticulum. Endoscopy and ultrasound were normal. The diagnosis was done by scintigraphy with technetium revealing an accumulation of radiotracer by mucous cells in ectopic gastric mucosa, which allows a detection of Meckel's diverticulum...
October 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28683236/the-results-of-parathyroid-hormone-assay-in-parathyroid-aspirates-in-preoperative-localization-of-parathyroid-adenomas-for-focused-parathyroidectomy-in-patients-with-negative-or-suspicious-technet%C3%A4-um-99-msestam%C3%A4-b%C3%A4-scans
#13
Aysenur Ozderya, Sule Temizkan, Kenan Cetin, Sule Ozugur, Aylin Ege Gul, Kadriye Aydin
OBJECTIVE: This study aims to evaluate the results of parathyroid hormone (PTH) assay in parathyroid aspirates to determine uniglandular disease by an endocrinologist-performed ultrasound in patients with discordant or negative technetium ((99m)Tc) sestamibi scans and to evaluate whether this pocedure increases the number of focused parathyroidectomy (FP). METHODS: We analyzed the data of 65 patients who underwent an endocrinologist-performed ultrasound (US) guided parathyroid fine needle aspiration (FNA) with PTH wash-out, retrospectively...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28680204/role-of-99m-tc-mdp-bone-scan-in-delineation-of-ischaemic-zone-in-cases-of-severe-frostbite
#14
Arun Ravi John, Anurag Jain, Braj Kishore, Aniruddha G Pandit
Frostbite or cold burn is the medical condition in which localized damage is caused to exposed skin and subcutaneous tissue due to freezing. Frostbite most likely involves body parts farthest from the heart and those with large exposed areas. At or below 0 °C (32 °F), blood vessels close to the skin start to constrict, and blood is shunted away from the extremities via the physiological feedback action of glomus bodies. This peripheral vasoconstriction helps to conserve core body temperature. In extreme cold, or when certain parts of the body are exposed to cold conditions for long periods, this protective mechanism can reduce blood flow in some areas of the body to dangerously low levels...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28680198/influence-of-decontaminating-agents-and-swipe-materials-on-laboratory-simulated-working-surfaces-wet-spilled-with-sodium-pertechnetate
#15
Suman Akchata, K Lavanya, Bhushan Shivanand
CONTEXT: Decontamination of various working surfaces with sodium pertechnetate minor spillage is essential for maintaining good radiation safety practices as well as for regulatory compliance. AIM: To observe the influences of decontaminating agents and swipe materials on different type of surfaces used in nuclear medicine laboratory work area wet spilled with 99m-technetium (99mTc) sodium pertechnetate. SETTINGS AND DESIGN: Lab-simulated working surface materials...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28667454/effects-of-cardiac-resynchronization-therapy-on-right-ventricular-function-during-rest-and-exercise-as-assessed-by-radionuclide-angiography-and-on-nt-probnp-levels
#16
Cinzia Valzania, Mauro Biffi, Rachele Bonfiglioli, Francesco Fallani, Cristian Martignani, Igor Diemberger, Matteo Ziacchi, Jessica Frisoni, Luciana Tomasi, Stefano Fanti, Claudio Rapezzi, Giuseppe Boriani
AIM: We carried out this study to investigate mid-term effects of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and neurohormonal response, expressed by N-terminal pro-brain natriuretic peptide (NT-proBNP), in heart failure patients stratified by baseline RV ejection fraction (RVEF). METHODS AND RESULTS: Thirty-six patients with nonischemic dilated cardiomyopathy underwent technetium-99m radionuclide angiography with bicycle exercise immediately after CRT implantation (during spontaneous rhythm and after CRT activation) and 3 months later...
June 30, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28658791/ectopic-parathyroid-adenoma-presenting-as-a-mediastinal-mass
#17
Aneesha Vaidya, Mangala Gouri, H M Sudha, Vijaya Mysorekar, Avinash Balekudura
A parathyroid adenoma present in an ectopic site, in the anterior mediastinum, is a rare cause of persistent hyperparathyroidism. Though its occurrence in the mediastinum is unusual, existence has been noted in literature for more than a century. We describe a case of a 35-year-old male presenting with complaints of pain abdomen, clinically diagnosed as acute necrotizing pancreatitis, with raised serum calcium. Patient received symptomatic treatment for the pancreatitis which subsided. However, high levels of serum calcium persisted...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28654377/image-based-analysis-of-tumor-localization-after-intra-arterial-delivery-of-technetium-99m-labeled-spio-using-spect-ct-and-mri
#18
In Joon Lee, Ji Yong Park, Young-Il Kim, Yun-Sang Lee, Jae Min Jeong, Jaeil Kim, Euishin Edmund Kim, Keon Wook Kang, Dong Soo Lee, Seonji Jeong, Eun Jeong Kim, Young Il Kim, Jin Wook Chung
The aim of this study is to evaluate the localization of (99m)Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered (99m)Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of (99m)Tc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28651446/acute-and-chronic-in-vivo-effects-of-exposure-to-nicotine-and-propylene-glycol-from-an-e-cigarette-on-mucociliary-clearance-in-a-murine-model
#19
Beth L Laube, Nima Afshar-Mohajer, Kirsten Koehler, Gang Chen, Philip Lazarus, Joseph M Collaco, Sharon A McGrath-Morrow
OBJECTIVE: To determine the effect of an acute (1 week) and chronic (3 weeks) exposure to E-cigarette (E-cig) emissions on mucociliary clearance (MCC) in murine lungs. METHODS: C57BL/6 male mice (age 10.5 ± 2.4 weeks) were exposed for 20 min/day to E-cigarette aerosol generated by a Joyetech 510-T(®) E-cig containing either 0% nicotine (N)/propylene glycol (PG) for 1 week (n = 6), or 3 weeks (n = 9), or 2.4% N/PG for one week (n = 6), or 3 weeks (n = 9), followed by measurement of MCC...
June 26, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28644197/preoperative-regional-maximal-removal-rate-of-technetium-99m-galactosyl-human-serum-albumin-is-correlated-with-liver-functional-parameters-but-did-not-predict-postoperative-morbidity
#20
Koichi Yano, Atsushi Nanashima, Yoshiro Fujii, Masahide Hiyoshi, Naoya Imamura, Takeomi Hamada, Yuki Tsuchimochi, Takashi Wada, Yoichi Mizutani, Toshinori Hirai
BACKGROUND: Recently, posthepatectomy complications have been predicted by advances of new liver functional parameters, and the technetium-99m-galactosyl human serum albumin (GSA) liver scintigraphy has been applied widely for this purpose. We evaluated the clinical significance of the regional maximal removal rate (GSA-Rmax) in patients with various liver diseases as predictors of posthepatectomy complications. PATIENTS AND METHODS: Between 2012 and March 2016, we examined 200 patients who underwent hepatectomy for liver and biliary diseases...
August 2017: Nuclear Medicine Communications
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