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Technetium 99m

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https://www.readbyqxmd.com/read/28917690/apical-to-base-gradient-of-technetium-99m-pyrophosphate-myocardial-counts-in-cardiac-amyloidosis-an-insight-into-the-mechanism-of-myocardial-strain-gradient-or-merely-clouds-that-mimic-land-before-the-sailor-s-eye
#1
EDITORIAL
https://www.readbyqxmd.com/read/28917675/regional-variation-in-technetium-pyrophosphate-uptake-in-transthyretin-cardiac-amyloidosis-and-impact-on%C3%A2-mortality
#2
Brett W Sperry, Michael N Vranian, Albree Tower-Rader, Rory Hachamovitch, Mazen Hanna, Richard Brunken, Dermot Phelan, Manuel D Cerqueira, Wael A Jaber
OBJECTIVES: This study sought to investigate the regional uptake of technetium 99m-pyrophosphate (TcPYP) in transthyretin cardiac amyloidosis (ATTR) and its association with mortality. BACKGROUND: TcPYP nuclear scintigraphy is a diagnostic and prognostic tool in ATTR. Echocardiography has identified a pattern of regional variation in longitudinal strain (LS) with a gradient of improved strain from base to apex in ATTR. METHODS: Consecutive patients with ATTR were evaluated who underwent TcPYP nuclear scintigraphy with planar and attenuation corrected single-photon emission computed tomography (SPECT)...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28916345/is-a-technetium-99m-macroaggregated-albumin-scan-essential-in-the-workup-for-selective-internal-radiation-therapy-with-yttrium-90-an-analysis-of-532-patients
#3
Lidia Sancho, Macarena Rodriguez-Fraile, Jose Ignacio Bilbao, Carmen Beorlegui Arteta, Mercedes Iñarrairaegui, Veronica Moran, Bruno Sangro
PURPOSE: To determine if baseline patient, tumor, and pretreatment evaluation characteristics could help identify patients who require technetium-99m ((99m)Tc) macroaggregated albumin ((99m)Tc MAA) imaging before selective internal radiation therapy (SIRT). MATERIALS AND METHODS: In this retrospective analysis, 532 consecutive patients with primary (n = 248) or metastatic (n = 284) liver tumors were evaluated between 2006 and 2015. Variables were compared between patients in whom (99m)Tc MAA imaging results contraindicated/modified SIRT administration with yttrium-90 ((90)Y) resin microspheres and those who were treated as initially planned...
September 13, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28912030/liver-function-assessment-using-technetium-99m-galactosyl-single-photon-emission-ct-ct-fusion-imaging-a-prospective-trial
#4
Takehiro Okabayashi, Yasuo Shima, Sojiro Morita, Yasuhiro Shimada, Tatsuaki Sumiyoshi, Kenta Sui, Jun Iwata, Tatsuo Iiyama
BACKGROUND: The prediction of postoperative liver function remains a largely subjective practice based on computed tomography (CT) volumetric analysis. However, the future liver volume after a hepatectomy is not the only factor that contributes to postoperative liver function and outcomes. STUDY DESIGN: In this prospective trial, 185 consecutive patients who underwent liver surgery between 2014 and 2015 were studied. Volumetric and functional rates of remnant liver were measured using technetium-99m-galactosyl human serum albumin single photon emission computed tomography/computed tomography ((99m)Tc-GSA SPECT/CT) fusion imaging to evaluate post-hepatectomy remnant liver function...
September 11, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28903124/early-monitoring-of-osteoporosis-treatment-response-by-technetium-99m-methylene-diphosphonate-bone-scan
#5
Jingjing Lou, Guanghua Wen, Ke Dong, Yifan Zhang
OBJECTIVE: The aim of this study was to investigate the effectiveness of a technetium-99m-methylene diphosphonate (Tc-MDP) bone scan and the bone mineral density (BMD) test in monitoring the efficacy of osteoporosis (OP) treatment. PATIENTS AND METHODS: A total of 50 women with OP were prospectively enrolled in this study from January 2011 to October 2016 in our hospital. All the patients underwent a Tc-MDP whole-body bone scan and the BMD test before and after alendronate sodium treatment at 3, 6, 12 and 18 months, respectively...
October 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28888827/tumor-dose-response-in-yttrium-90-resin-microsphere-embolization-for-neuroendocrine-liver-metastases-a-tumor-specific-analysis-with-dose-estimation-using-spect-ct
#6
Orapin Chansanti, Younes Jahangiri, Yusuke Matsui, Akira Adachi, Yindee Geeratikun, John A Kaufman, Kenneth J Kolbeck, Jeffrey S Stevens, Khashayar Farsad
PURPOSE: To evaluate dose-response relationship in yttrium-90 ((90)Y) resin microsphere radioembolization for neuroendocrine tumor (NET) liver metastases using a tumor-specific dose estimation based on technetium-99m-labeled macroaggregated albumin ((99m)Tc MAA) single photon emission computed tomography (SPECT)-CT. MATERIALS AND METHODS: Fifty-five tumors (mean size 3.9 cm) in 15 patients (10 women; mean age 57 y) were evaluated. Tumor-specific absorbed dose was estimated using a partition model...
September 6, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28886422/initial-evaluation-of-a-99m-tc-cyclopentadienyltricarbonyl-technetium-complex-as-a-potential-5-ht1a-receptor-imaging-agent
#7
Nadia Malek Saied, Najoua Mejri, Mouna Raddaoui, Mouldi Saidi
No abstract text is available yet for this article.
August 31, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28885540/stress-only-myocardial-perfusion-scintigraphy-a-prospective-study-on-the-accuracy-and-observer-agreement-with-quantitative-coronary-angiography-as-the-gold-standard
#8
June A Ejlersen, Ole May, Jesper Mortensen, Gitte L Nielsen, Jeppe F Lauridsen, Johansen Allan
OBJECTIVE: Patients with normal stress perfusion have an excellent prognosis. Prospective studies on the diagnostic accuracy of stress-only scans with contemporary, independent examinations as gold standards are lacking. PATIENTS AND METHODS: A total of 109 patients with typical angina and no previous coronary artery disease underwent a 2-day stress (exercise)/rest, gated, and attenuation-corrected (AC), 99m-technetium-sestamibi perfusion study, followed by invasive coronary angiography...
September 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28875761/an-ultralow-dose-1-day-protocol-with-activities-lower-than-20-mbq-for-the-detection-of-sentinel-lymph-nodes-in-breast-cancer-experiences-after-150-cases
#9
Hans-Christian Kolberg, Shabnam Afsah, Thorsten Kuehn, Ute Winzer, Leyla Akpolat-Basci, Miltiades Stephanou, Sarah Wetzig, Oliver Hoffmann, Cornelia Liedtke
INTRODUCTION: Common protocols for the detection of sentinel lymph nodes in early breast cancer often include the injection of the tracer 1 day before surgery. In order to detect enough activity on the day of surgery, the applied activity in many protocols is as high as several hundred MBq. So far, very few protocols with an activity below 20 MBq have been reported. We developed an ultralow-dose 1-day protocol with a mean activity lower than 20 MBq in order to reduce radiation exposure for patients and staff...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28862179/influence-of-single-photon-emission-computed-tomography-spect-reconstruction-algorithm-on-diagnostic-accuracy-of-parathyroid-scintigraphy-comparison-of-iterative-reconstruction-with-filtered-backprojection
#10
Gonca Kara Gedik, Oktay Sari
BACKGROUND & OBJECTIVES: Preoperative localization of parathyroid lesions is essential for improving the results in patients with primary hyperparathyroidism. The purpose of this study was to evaluate retrospectively the value of technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) single photon emission computed tomography (SPECT) and to compare the diagnostic accuracy of iterative reconstruction (IR) and filtered backprojection (FBP) reconstruction algorithms about localization of parathyroid lesions...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28845737/biodistribution-study-of-99m-tc-gemcitabine-loaded-spherulites-in-sprague-dawley-rats-by-gamma-scintigraphy-to-investigate-its-lung-targeting-potential
#11
Rahul Dhande, Amit Tyagi, Rakesh Kumar Sharma, Hetal Thakkar
Gemcitabine Hydrochloride (GCH) is drug of choice for treatment of Non-Small Cell Lung Cancer. This project aims to formulate GCH loaded Spherulites for lung targeting using Soyabean Phosphatidylcholine, Cholesterol and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]. Vesicles were characterized for size, entrapment efficiency, drug release and in vitro cytotoxicity. Radiolabeling of GCH was done using reduced technetium-99m to study biodistribution in Sprague Dawley rats...
August 28, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28837044/estimation-of-lung-shunt-fraction-from-simultaneous-fluoroscopic-and-nuclear-images
#12
Sandra van der Velden, Remco Bastiaannet, Arthur J A T Braat, Marnix G E H Lam, Max A Viergever, Hugo W A M de Jong
Radioembolisation with yttrium-90 (<sup>90</sup>Y) is increasingly used as a treatment of unresectable liver malignancies. For safety, a scout dose of technetium-99m macroaggregated albumin (<sup>99m</sup>Tc-MAA) is used prior to the delivery of the therapeutic activity to mimic the deposition of <sup>90</sup>Y. One-day procedures are currently limited by the lack of nuclear images in the intervention room. To cope with this limitation, an interventional simultaneous fluoroscopic and nuclear imaging device is currently being developed...
August 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28829079/technetium-99m-based-small-molecule-radiopharmaceuticals-and-radiotracers-targeting-inflammation-and-infection
#13
Torsten Kniess, Markus Laube, Frank Wüst, Jens Pietzsch
In nuclear medicine, the detection of inflamed and infected lesions is of growing interest. Extensive efforts have been made to develop radiopharmaceuticals specific for inflammation or for discriminating sterile inflammation from infection. (99m)Tc is the worldwide most widely used radioisotope for SPECT imaging. The scope of this review article is to give an overview on the development of (99m)Tc-labelled small molecule radiotracers targeting inflammatory lesions and infections, ranging from their radiopharmacological evaluation to examples of their clinical applications...
August 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28828528/sentinel-lymph-node-mapping-in-endometrial-cancer-comparison-of-fluorescence-dye-with-traditional-radiocolloid-and-blue
#14
REVIEW
Andrea Papadia, Maria Luisa Gasparri, Alessandro Buda, Michael D Mueller
Sentinel lymph node (SLN) mapping in endometrial cancer (EMCA) is rapidly gaining acceptance in the clinical community. As compared to a full lymphadenectomy in every patient, to a selective lymphadenectomy after frozen section of uterus in selected patients with intrauterine risk factors or to a strategy in which a lymphadenectomy is always omitted, SLN mapping seems to be a reasonable and oncologically safe middle ground. Various protocols can be used when applying an SLN mapping. In this manuscript we review the characteristics, toxicity and clinical impact of technetium-99m radiocolloid (Tc-99m), of the blue dyes (methylene blue, isosulfan blue and patent blue) and of indocyanine green (ICG)...
August 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28827905/clinical-utility-of-tc-99m-mibi-spect-ct-for-preoperative-localization-of-parathyroid-lesions
#15
Zeynep Gozde Ozkan, Seher Nilgun Unal, Serkan Kuyumcu, Yasemin Sanli, Mehmet Fatih Gecer, Beyza Ozcinar, Yasemin Senyurek Giles, Yesim Erbil
We aimed to demonstrate the role of SPECT/CT in preoperative localization of parathyroid lesions in patients with hyperparathyroidism who had technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) dual-phase parathyroid scintigraphy. We evaluated retrospectively the scintigraphic data of 103 patients who had parathyroidectomy after Tc-99m MIBI dual-phase parathyroid scintigraphy with SPECT/CT. The planar and SPECT/CT images were evaluated separately to determine their efficacy in localizing parathyroid lesions...
August 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28819506/-parathyroid-carcinoma-about-a-case-and-review-of-the-literature
#16
REVIEW
Naourez Kolsi, Sondos Jellali, Jamel Koubaa
Parathyroid carcinoma is a very rare malignant tumor of the parathyroid gland. Clinically, this cancer is characterized by the presence of severe primary hyperparathyroidism. Diagnosis is based on histological examination but is not always easy. Surgery is the treatment of choice. We report the case of a 59-year old woman with a personal history of arterial hypertension and of recurrent renal lithiasis, presenting with diffuse bone pain associated with asthenia. Neck examination showed hard basi-cervical swelling with nonpalpable lower edge...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28816013/new-neurotensin-analogue-radiolabeled-by-99m-technetium-as-a-potential-agent-for-tumor-identification
#17
Iman Emrarian, Nourollah Sadeghzadeh, Seyed Mohammad Abedi, Saeid Abediankenari
INTRODUCTION: It has been shown that more than 75% of ductal pancreatic adenocarcinomas are overexpress neurotensin (NT) receptors. Overexpression of NT receptors has been reported in various human tumor types. Hence, a non-invasive diagnosis and staging method could be very beneficial. In this work, we describe radiolabeling and evaluation of new neurotensin analogues to target neurotensin receptor-positive tumors such as pancreatic carcinoma. METHODS: Radiolabeling was performed at 95°C for 10 min using(99m) Tc in the presence of tricine/EDDA exchange labeling...
August 16, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28814251/the-role-of-radiopharmaceuticals-in-amiodarone-induced-thyroid-pathology
#18
Doina Piciu, Alexandru Irimie
Amiodarone is a di-iodinated benzofuran derivative and is classified as a class III antiarrhythmic agent. It is one of the most powerful and effective antiarrhythmics, being a first-line agent due to its ability to treat ventricular and supraventricular dysrhythmias; since 1960 the drug has become one of the most frequently prescribed antiarrhythmics, despite its potentially serious, side effects. By far, one of the most challenging condition is the thyroid pathology induced by this drug. Each 200 mg tablet of amiodarone contains approximately 75 mg of iodine, 3-10% from each tablet being released as free iodine...
August 16, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28813561/comparison-of-coronary-ct-angiography-spect-pet-and-hybrid-imaging-for-diagnosis-of-ischemic-heart-disease-determined-by-fractional-flow-reserve
#19
Ibrahim Danad, Pieter G Raijmakers, Roel S Driessen, Jonathon Leipsic, Rekha Raju, Chris Naoum, Juhani Knuuti, Maija Mäki, Richard S Underwood, James K Min, Kimberly Elmore, Wynand J Stuijfzand, Niels van Royen, Igor I Tulevski, Aernout G Somsen, Marc C Huisman, Arthur A van Lingen, Martijn W Heymans, Peter M van de Ven, Cornelis van Kuijk, Adriaan A Lammertsma, Albert C van Rossum, Paul Knaapen
Importance: At present, the choice of noninvasive testing for a diagnosis of significant coronary artery disease (CAD) is ambiguous, but nuclear myocardial perfusion imaging with single-photon emission tomography (SPECT) or positron emission tomography (PET) and coronary computed tomography angiography (CCTA) is predominantly used for this purpose. However, to date, prospective head-to-head studies are lacking regarding the diagnostic accuracy of these imaging modalities. Furthermore, the combination of anatomical and functional assessments configuring a hybrid approach may yield improved accuracy...
August 16, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28806349/dual-phase-99mtc-mibi-imaging-and-the-expressions-of-p-gp-gst-%C3%AF-and-mrp1-in-hyperparathyroidism
#20
Jianjun Xue, Yan Liu, Danrong Yang, Yan Yu, Qianqian Geng, Ting Ji, Lulu Yang, Qi Wang, Yuanbo Wang, Xueni Lu, Aimin Yang
OBJECTIVE: The aim of this study was to further elucidate the mechanisms of dual-phase technetium-99m methoxyisobutylisonitrile (Tc-MIBI) parathyroid imaging by exploring the association between early uptake results (EUR), delayed uptake results (DUR), and the retention index (RI) in dual-phase Tc-MIBI parathyroid imaging and P glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and glutathione S-transferase-π (GST-π) expression in hyperparathyroidism (HPT). PATIENTS AND METHODS: Preoperative dual-phase (early and delayed) Tc-MIBI imaging was performed on 74 patients undergoing parathyroidectomy for HPT...
October 2017: Nuclear Medicine Communications
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