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Technetium 99m

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https://www.readbyqxmd.com/read/29145285/degeneration-of-paramedian-nuclei-in-the-thalamus-induces-holmes-tremor-in-a-case-of-artery-of-percheron-infarction
#1
Tz-Shiang Wei, Chun-Sheng Hsu, Yu-Chun Lee, Shin-Tsu Chang
RATIONALE: Holmes' tremor is an uncommon neurologic disorder following brain insults, and its pathogenesis is undefined. The interruption of the dento-rubro-thalamic tract and secondary deterioration of the nigrostriatal pathway are both required to initiate Holmes' tremor. We used nuclear medicine imaging tools to analyze a patient with concurrent infarction in different zones of each side of the thalamus. Finding whether the paramedian nuclear groups of the thalamus were injured was a decisive element for developing Holmes' tremor...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142364/bone-scan-in-evaluation-of-bone-viability-in-severe-frostbite-of-the-hand
#2
Ishan Garg, Maria J Baladron Zanetti, Ayse T Kendi
A 39-year-old male presented to the emergency department (ED) with frostbite to the fingers of both hands. In the ED, he received warm baths, acetylsalicylic acid, clopidogrel, and heparin. A three-phase bone scintigraphy with technetium-99m-methylene diphosphonate revealed absent radiotracer uptake in distal phalanges of both hands. The patient received acetylsalicylic acid, clopidogrel and wound care for the next 5 days and made an excellent recovery with satisfactory wound healing in both hands. Early rapid rewarming and reperfusion can improve the prognosis significantly and therefore bone scan done within first 1-2 days may give spurious results...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29142344/investigating-the-role-of-global-histogram-equalization-technique-for-99m-technetium-methylene-diphosphonate-bone-scan-image-enhancement
#3
Anil Kumar Pandey, Param Dev Sharma, Pankaj Dheer, Girish Kumar Parida, Harish Goyal, Chetan Patel, Chandrashekhar Bal, Rakesh Kumar
Purpose of the Study: (99m)Technetium-methylene diphosphonate ((99m)Tc-MDP) bone scan images have limited number of counts per pixel, and hence, they have inferior image quality compared to X-rays. Theoretically, global histogram equalization (GHE) technique can improve the contrast of a given image though practical benefits of doing so have only limited acceptance. In this study, we have investigated the effect of GHE technique for (99m)Tc-MDP-bone scan images. Materials and Methods: A set of 89 low contrast (99m)Tc-MDP whole-body bone scan images were included in this study...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29116562/prediction-of-long-term-%C3%A2-10%C3%A2-year-cardiovascular-outcomes-in-heart-transplant-recipients-value-of-stress-technetium-99m-tetrofosmin-myocardial-perfusion-imaging
#4
Jesse F Veenis, Hendrik J Boiten, Jan C van den Berge, Kadir Caliskan, Alex P W M Maat, Roelf Valkema, Alina A Constantinescu, Olivier C Manintveld, Felix Zijlstra, Ron T van Domburg, Arend F L Schinkel
BACKGROUND: Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) is useful in the evaluation of cardiac allograft vasculopathy (CAV) in heart transplant (HTx) recipients. The current study evaluated the long-term prognostic value of stress SPECT MPI for predicting all-cause mortality and cardiac events in HTx recipients. METHODS: The study population consisted of 166 HTx recipients (mean age 54 ± 10 years, 84% male) who underwent exercise or dobutamine stress (99m)Tc-tetrofosmin SPECT MPI for the assessment of CAV...
November 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29116215/comparative-evaluation-of-tumor-targeting-using-the-anti-her2-adapt-scaffold-protein-labeled-at-the-c-terminus-with-indium-111-or-technetium-99m
#5
Javad Garousi, Sarah Lindbo, Bogdan Mitran, Jos Buijs, Anzhelika Vorobyeva, Anna Orlova, Vladimir Tolmachev, Sophia Hober
ABD-Derived Affinity Proteins (ADAPTs) is a novel class of engineered scaffold proteins derived from an albumin-binding domain of protein G. The use of ADAPT6 derivatives as targeting moiety have provided excellent preclinical radionuclide imaging of human epidermal growth factor 2 (HER2) tumor xenografts. Previous studies have demonstrated that selection of nuclide and chelator for its conjugation has an appreciable effect on imaging properties of scaffold proteins. In this study we performed a comparative evaluation of the anti-HER2 ADAPT having an aspartate-glutamate-alanine-valine-aspartate-alanine-asparagine-serine (DEAVDANS) N-terminal sequence and labeled at C-terminus with (99m)Tc using a cysteine-containing peptide based chelator, glycine-serine-serine-cysteine (GSSC), and a similar variant labeled with (111)In using a maleimido derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110007/recent-development-of-luminescent-rhenium-i-tricarbonyl-polypyridine-complexes-as-cellular-imaging-reagents-anticancer-drugs-and-antibacterial-agents
#6
Lawrence Cho-Cheung Lee, Kam-Keung Leung, Kenneth Kam-Wing Lo
There has been fast-growing interest in the exploitation of the photophysical and photochemical properties of luminescent transition metal complexes in biological applications, with a focus on both diagnostic and therapeutic aspects. In particular, the design of luminescent rhenium(i) tricarbonyl polypyridine complexes as cellular imaging reagents and anticancer drugs has received considerable attention for a number of reasons. First, most rhenium(i) tricarbonyl polypyridine complexes possess diverse photophysical and photochemical properties through the coordination of functionalized ligands...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29099413/preoperative-maximal-removal-rate-of-technetium-99m-galactosyl-human-serum-albumin-of-the-remnant-liver-is-associated-with-postoperative-tumor-relapse-in-hepatitis-c-virus-related-hepatocellular-carcinoma
#7
Koichi Yano, Kazuhiro Kondo, Atsushi Nanashima, Yoshiro Fujii, Naoya Imamura, Masahide Hiyoshi, Takeomi Hamada, Yuki Tsuchimochi, Takashi Wada, Yoichi Mizutani, Toshinori Hirai
BACKGROUND: Prognosis in patients with hepatocellular carcinoma (HCC) is not only influenced by tumor-related factors but also by the background liver functions. The maximal removal rate of technetium-99m-galactosyl human serum albumin (GSA-Rmax) of the remnant liver (rGSA-Rmax) is a useful candidate for predicting the liver function and clarifying the relationship between the remnant liver functional reserve and tumor-free survival in patients who have undergone hepatectomy. PATIENTS AND METHODS: One hundred and sixty-five patients with HCC who underwent curative hepatectomy were divided into three groups of hepatitis B virus (B-HCC; n=42), hepatitis C virus (C-HCC, n=58), and non-B, non-C (NBNC-HCC, n=65)...
November 2, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29098558/radiosynthesis-and-biodistribution-of-99m-tc-metronidazole-as-an-escherichia-coli-infection-imaging-radiopharmaceutical
#8
Anam Iqbal, Syed Ali Raza Naqvi, Rashid Rasheed, Asim Mansha, Matloob Ahmad, Ameer Fawad Zahoor
Bacterial infection poses life-threatening challenge to humanity and stimulates to the researchers for developing better diagnostic and therapeutic agents complying with existing theranostic techniques. Nuclear medicine technique helps to visualize hard-to-diagnose deep-seated bacterial infections using radionuclide-labeled tracer agents. Metronidazole is an antiprotozoal antibiotic that serves as a preeminent anaerobic chemotherapeutic agent. The aim of this study was to develop technetium-99m-labeled metronidazole radiotracer for the detection of deep-seated bacterial infections...
November 2, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29098518/the-detection-of-sentinel-lymph-nodes-in-laparoscopic-surgery-can-eliminate-systemic-lymphadenectomy-for-patients-with-early-stage-endometrial-cancer
#9
Tomohito Tanaka, Yoshito Terai, Satoe Fujiwara, Yoshimichi Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
BACKGROUND: The examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer. STUDY DESIGN: Two hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid ((99m)Tc), indigo carmine and indocyanine green...
November 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29091899/paclitaxel-loaded-folate-coated-long-circulating-and-ph-sensitive-liposomes-as-a-potential-drug-delivery-system-a-biodistribution-study
#10
Liziane O F Monteiro, Renata S Fernandes, Caroline M R Oda, Sávia C Lopes, Danyelle M Townsend, Valbert N Cardoso, Mônica C Oliveira, Elaine A Leite, Domenico Rubello, André L B de Barros
A range of antitumor agents for cancer treatment is available; however, they show low specificity, which often limit their use. Recently, we have reported the preparation of folate-coated long-circulating and pH-sensitive liposomes (SpHL-folate-PTX) loaded with paclitaxel (PTX), an effective drug for the treatment of solid tumors, including breast cancer. The purpose of this study was to prepare and characterize SpHL-PTX and SpHL-folate-PTX radiolabeled with technetium-99m ((99m)Tc). Biodistribution studies and scintigraphic images were performed after intravenous administration of (99m)Tc-PTX, (99m)Tc-SpHL-PTX and (99m)Tc-SpHL-folate-PTX into healthy and tumor-bearing mice...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29079916/formulation-of-99m-technetium-labeled-leuprolide-loaded-liposomes-and-its-biodistribution-study-in-new-zealand-white-female-rabbits-for-assessment-of-its-uterine-targeting-efficiency
#11
Arpita Patel, Amit Tyagi, Rakesh Kumar Sharma, Hetal Thakkar
Leuprolide acetate (LPA), a GnRH analogue, is drug of choice for treatment of uterine fibroids and endometriosis. The current marketed formulations of LPA show severe systemic side effects. This project aims to formulate LPA loaded liposomes to be administered by vaginal route for uterine targeting. Liposomes were prepared by thin film hydration method using 1:1 M ratio of DSPC: Cholesterol and characterized for vesicle size, zeta potential, entrapment efficiency, and loading. Radiolabeling of LPA was performed by direct labeling with reduced technetium-99m...
October 27, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29069572/blood-flow-volume-and-arterio-venous-passages-in-induced-mammary-tumours-of-the-rat
#12
Ragnar Hultborn
OBJECTIVE: To study blood flow, vascular volume and arterio-venous passages in induced mammary tumours of the rat to characterize parameters possibly responsible for tumour hyponutrition. METHOD: Dimethylbenzanthracene-induced mammary tumours in Sprague-Dawley rats were studied. Regional blood flow was studied by use of the radioactive microsphere tracer technique using (141)Cerium-labelled 15μm spheres coinjected into the left cardiac ventricle with (125)Iodine-labelled 25μm spheres...
October 22, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29039327/formulation-of-lyophilized-single-vial-kit-of-n-n-ethylene-l-dicysteine-ec-for-labeling-with-99m-tc-ii-radiochemical-and-clinical-evaluation-as-a-renal-tubular-agent-in-comparison-with-99m-tc-mag3
#13
Anjum Afshan, Mohammad Sohaib, Mohammad Jehangir
A Technetium (99m)Tc labeled lyophilized single component kit of N-N-ethylene-I-dicysteine (EC) is developed to replace multiple step kit developed by others. The aim of study is to formulate a radionuclide that is easy to prepare, has rapid plasma clearance, produce high quality images and is an affective alternative to radioiodine labeled orthoiodohippurate, which has been remained the physiological 'gold standard' since long time. To achieve this goal, the systematically varied key parameters such as pH, the use of reducing agents, stabilizers and additives are optimized to obtain maximum radiochemical purity and optimum biodistribution in non human and human primates...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29035122/homogeneity-of-aerosol-deposition-and-mucociliary-clearance-are-improved-following-ivacaftor-treatment-in-cystic-fibrosis
#14
William D Bennett, Kirby L Zeman, Beth L Laube, Jihong Wu, Gail Sharpless, Peter J Mogayzel, Scott H Donaldson
BACKGROUND: Using planar gamma scintigraphy of inhaled radioaerosols, we have developed new analytical methods for assessing homogeneity of aerosol deposition and time-dependent particle clearance on a pixel-by-pixel basis, and applied them to a therapeutic cystic fibrosis (CF) study. METHODS: At baseline and 1 month after beginning treatment with ivacaftor, a cystic fibrosis transmembrane regulator modulator for CF patients with at least one copy of the G551D mutation (n = 13), initial deposition and subsequent mucociliary clearance (MCC) of radiolabeled particles ((99m)Technetium-sulfur colloid, 5 μm mass median aerodynamic diameter) inhaled under controlled breathing conditions were measured...
October 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29033680/the-utility-of-99m-technetium-mercaptoacetyltriglycine-renogram-in-assessing-the-baseline-renal-function-of-a-rare-incidental-ectopic-thoracic-kidney
#15
Ting-Ting Zhang, Adanna Oparandu, Ziauddin Saad
Ectopic thoracic kidney is an extremely rare condition caused by the abnormal location of one or both kidneys in the thoracic cavity. They are usually discovered incidentally on routine imaging. Although commonly asymptomatic, thoracic kidneys are at a risk of malrotation, pelviureteric junction obstruction, and subsequent obstructive nephropathy, by virtue of their long pedicle. We present a case report of an incidental thoracic kidney, for which a (99m)technetium-mercaptoacetyltriglycine ((99m)Tc-MAG3) renogram was performed to assess the baseline renal function...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29030760/patient-specific-dosimetry-of-99m-tc-hynic-tyr-3-octreotide-in-children
#16
Xinchi Hou, Bozena Birkenfeld, Hanna Piwowarska-Bilska, Anna Celler
BACKGROUND: Technetium-99m-hydrazinonicotinamide-Tyr(3)-octreotide ((99m)Tc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, (99m)Tc-HYNIC-TOC dosimetry has been investigated only for adults. As pediatric radionuclide therapies become increasingly common, similar dosimetric studies for children are urgently needed. The aim of this study is to report personalized image-based biodistributions and dosimetry evaluations for children studies performed using (99m)Tc-HYNIC-TOC and to compare them with those from adult subjects...
October 13, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29023153/predictability-of-99m-tc-galactosyl-human-serum-albumin-scintigraphy-for-posthepatectomy-liver-failure
#17
Ayako Kato, Yuji Nakamoto, Takayoshi Ishimori, Satoru Seo, Shinji Uemoto, Kaori Togashi
OBJECTIVE: Posthepatectomy liver failure (PHLF) is one of the most serious complications after hepatectomy. The objective of the present study is to assess the potential diagnostic ability of (99m)Tc-galactosyl human serum albumin (GSA) scintigraphy to predict PHLF as defined by the International Study Group of Liver Surgery (ISGLS). MATERIALS AND METHODS: Data from 100 patients who underwent (99m)Tc-GSA scintigraphy and subsequent hepatectomy were retrospectively analyzed...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29019612/unveiling-transthyretin-cardiac-amyloidosis-and-its-predictors-among-elderly-patients-with-severe-aortic-stenosis-undergoing-transcatheter-aortic-valve-replacement
#18
Adam Castaño, David L Narotsky, Nadira Hamid, Omar K Khalique, Rachelle Morgenstern, Albert DeLuca, Jonah Rubin, Codruta Chiuzan, Tamim Nazif, Torsten Vahl, Isaac George, Susheel Kodali, Martin B Leon, Rebecca Hahn, Sabahat Bokhari, Mathew S Maurer
Aims: Transthyretin cardiac amyloidosis (ATTR-CA) has been reported in patients with aortic stenosis (AS) but its prevalence and phenotype are not known. We examine elderly patients with severe symptomatic AS undergoing transcatheter aortic valve replacement (TAVR) and determine the prevalence and phenotype of ATTR-CA non-invasively. Methods and results: We performed technetium-99m pyrophosphate (99mTc-PYP) cardiac scintigraphy prospectively on patients who underwent TAVR, to screen for ATTR-CA...
October 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28994250/synthesis-and-evaluation-of-a-novel-99m-tc-nitrido-radiopharmaceutical-with-alendronate-dithiocarbamate-as-a-potential-bone-imaging-agent
#19
Xiaoqing Song, Yue Wang, Junbo Zhang, Zhonghui Jin, Weifang Zhang, Yanyan Zhang
Currently, a popular strategy for designing novel radioprobes as bone imaging agents is based on the concept of bifunctional radiopharmaceticals. Considering the dithiocarbamate ligand can act as a suitable bifunctional linking agent to attach technetium-99m ((99m) Tc) to corresponding target molecules, in this study, alendronate dithiocarbamate (ALNDTC) was synthesized and radiolabeled with [(99m) Tc≡N](2+) core by ligand-exchange reaction to produce (99m) TcN-ALNDTC complex, for the potential use as a novel probe for bone imaging...
October 10, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28992125/a-new-method-for-studying-cryptococcosis-in-a-murine-model-using-99mtc-cryptococcus-gattii
#20
Marliete Carvalho Costa, Lays Murta Mata, Noelly de Queiroz Ribeiro, Anderson Philip Nonato Santos, Lorena Vivien Neves Oliveira, Raquel Virgínia Rocha Vilela, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes, Daniel Assis Santos
Cryptococcus gattii is one of the etiologic agents of cryptococcosis, a systemic mycosis that occurs in healthy and immunosuppressed humans and animals worldwide. Primary pulmonary infection caused by C. gattii is usually followed by fungal dissemination to the central nervous system, resulting in high mortality rates. In this context, animal models of cryptococcosis are useful in the study of fungal pathogenesis and host response against the pathogen, and for testing novel therapeutic options. The most frequently applied method to study fungal dissemination from the lungs to other organs is by culturing tissues, which is not accurate for the detection and quantification of fungal load at early stages of the infection...
September 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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