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Technetium 99m

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https://www.readbyqxmd.com/read/28813561/comparison-of-coronary-ct-angiography-spect-pet-and-hybrid-imaging-for-diagnosis-of-ischemic-heart-disease-determined-by-fractional-flow-reserve
#1
Ibrahim Danad, Pieter G Raijmakers, Roel S Driessen, Jonathon Leipsic, Rekha Raju, Chris Naoum, Juhani Knuuti, Maija Mäki, Richard S Underwood, James K Min, Kimberly Elmore, Wynand J Stuijfzand, Niels van Royen, Igor I Tulevski, Aernout G Somsen, Marc C Huisman, Arthur A van Lingen, Martijn W Heymans, Peter M van de Ven, Cornelis van Kuijk, Adriaan A Lammertsma, Albert C van Rossum, Paul Knaapen
Importance: At present, the choice of noninvasive testing for a diagnosis of significant coronary artery disease (CAD) is ambiguous, but nuclear myocardial perfusion imaging with single-photon emission tomography (SPECT) or positron emission tomography (PET) and coronary computed tomography angiography (CCTA) is predominantly used for this purpose. However, to date, prospective head-to-head studies are lacking regarding the diagnostic accuracy of these imaging modalities. Furthermore, the combination of anatomical and functional assessments configuring a hybrid approach may yield improved accuracy...
August 16, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28806349/dual-phase-99mtc-mibi-imaging-and-the-expressions-of-p-gp-gst-%C3%AF-and-mrp1-in-hyperparathyroidism
#2
Jianjun Xue, Yan Liu, Danrong Yang, Yan Yu, Qianqian Geng, Ting Ji, Lulu Yang, Qi Wang, Yuanbo Wang, Xueni Lu, Aimin Yang
OBJECTIVE: The aim of this study was to further elucidate the mechanisms of dual-phase technetium-99m methoxyisobutylisonitrile (Tc-MIBI) parathyroid imaging by exploring the association between early uptake results (EUR), delayed uptake results (DUR), and the retention index (RI) in dual-phase Tc-MIBI parathyroid imaging and P glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and glutathione S-transferase-π (GST-π) expression in hyperparathyroidism (HPT). PATIENTS AND METHODS: Preoperative dual-phase (early and delayed) Tc-MIBI imaging was performed on 74 patients undergoing parathyroidectomy for HPT...
August 11, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28803178/treatment-of-unstable-thoracolumbar-fractures-does-fracture-level-fixation-accelerate-the-bone-healing
#3
Zühtü Özbek, Emre Özkara, Hasan Önner, Gültekin Baş, İpek Canan Erman, Hülya Özen, Emre Entok, Ali Arslantaş
OBJECTIVE: This study aimed to investigate the effect of fusion on short segment including fractured level (SSIFL) and long segment (LS) transpedicular fixation after acute thoracolumbar junction (TLJ) burst fractures. The two-year clinical and radiological follow-up results of the two groups were also compared. METHODS: Seventy-four patients were randomized into one of two groups: SSIFL (n: 39) or LS (n: 35). The SSIFL group included one level above and one level below, including the fracture level, while the LS group included two levels above and two levels below, excluding the fracture level, for the transpedicular fixation...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28798229/role-of-technetium-99m-methylene-diphosphonate-spect-ct-in-the-detection-of-sacroiliitis-in-patients-with-spondyloarthropathy-comparison-with-clinical-markers-and-mri
#4
Rahul V Parghane, Baljinder Singh, Aman Sharma, Harmandeep Singh, Paramjit Singh, Anish Bhattacharya
Rationale: To evaluate the role of (99m)Tc-MDP SPECT/CT for the detection of sacroiliitis in spondyloarthopathies (SpA) and comparison with clinical markers and MRI. Methods: A total of 155 diagnosed patients (83M : 72 F; mean age 35.80±12.40 years; range 18-60 years ) with SpA as per the European Spondyloarthropathy Study Group criteria (ESSG) criteria were prospectively included All the patients were subjected to clinical evaluation (using BASDAI scoring), ESR, CRP levels, planar (99m)Tc MDP bone scintigraphy, hybrid SPECT/CT and MRI of the pelvic region...
August 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28796070/clinical-characteristics-of-meckel-diverticulum-in-children-a-retrospective-review-of-a-15-year-single-center-experience
#5
Xiao-Kun Lin, Xiao-Zhong Huang, Xiao-Zhou Bao, Na Zheng, Qiong-Zhang Xia, Cong-de Chen
Meckel diverticulum is the most prevalent congenital abnormality of the gastrointestinal tract in children. The aim of this study was to review and analyze clinical data on the diagnosis and management of Meckel diverticulum in pediatric patients. The records of 102 pediatric patients (<14 years old) who underwent surgery for Meckel diverticulum at our institute between 2001 and 2015 were reviewed. Clinical, imaging, laboratory, surgical, and pathological data were recorded. The series comprised 65 males and 37 females with a median age of 5...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795363/fibroblast-growth-factor-type-1-fgf1-overexpressed-adipose-derived-mesenchaymal-stem-cells-ad-msc-fgf1-induce-neuroprotection-and-functional-recovery-in-a-rat-stroke-model
#6
Hamed Ghazavi, Seyed Javad Hoseini, Alireza Ebrahimzadeh-Bideskan, Baratali Mashkani, Soghra Mehri, Ahmad Ghorbani, Kayvan Sadri, Elahe Mahdipour, Faezeh Ghasemi, Fatemeh Forouzanfar, Azar Hoseini, Ali Reza Pasdar, Hamid Reza Sadeghnia, Majid Ghayour-Mobarhan
Stroke, as the second most common cause of death, imposes a great financial burden on both the individual and society. Mesenchymal stem cells from rodents have demonstrated efficacy in experimental animal models of stroke due to enhanced neurological recovery. Since FGF1 (fibroblast growth factor 1) displays neuroprotective properties, for the first time, we investigated the effect of acute intravenous administration of FGF1 gene transfected adipose-derived mesenchymal stem cell (AD-MSC(FGF1)) on transient experimental ischemic stroke in rats...
August 9, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28778082/radiolabelled-polymeric-iga-from-biodistribution-to-a-new-molecular-imaging-tool-in-colorectal-cancer-lung-metastases
#7
Helene Carpenet, Armelle Cuvillier, Aurélie Perraud, Ophélie Martin, Gaël Champier, Marie-Odile Jauberteau, Jacques Monteil, Isabelle Quelven
By radiolabelling monomeric (m) and polymeric (p) IgA with technetium 99m (99mTc), this study assessed IgA biodistribution and tumour-targeting potency. IgA directed against carcinoembryonic antigen (CEA), a colorectal cancer marker, was selected to involve IgA mucosal tropism.Ig was radiolabelled with 99mTc-tricarbonyl after derivatisation by 2-iminothiolane. 99mTc-IgA was evaluated by in vitro analysis. The biodistributions of radiolabelled anti-CEA mIgA, pIgA and IgG were compared in normal mice. Anti-CEA pIgA tumour uptake was studied in mice bearing the WiDr caecal orthotopic graft...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28777221/characterization-of-resolution-sensitivity-and-shielding-of-a-gamma-probe-for-sentinel-lymph-node-localization-an-experimental-study
#8
Emerson N Itikawa, Leonardo A Santos, Ana C Trevisan, Felipe A Pitella, Mery Kato, Eder R Moraes, Lauro Wichert-Ana
OBJECTIVE: The aim of this study was to evaluate angular, spatial, and energy resolution, sensitivity, and shielding of a gamma-probe. MATERIALS AND METHODS: The EUROPROBE II gamma-probe (EuroRad) with sources of technetium-99m was assessed according to NEMA NU-3-2004. Resolution tests were evaluated considering the full width at half maximum (FWHM). The following parameters were evaluated: angular resolution in air, spatial resolution with a scattering medium and in air, energy resolution, and sensitivity and shielding...
August 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28766938/rhenium-and-technetium-oxo-complexes-with-thioamide-derivatives-of-pyridylhydrazine-bifunctional-chelators-conjugated-to-the-tumour-targeting-peptides-octreotate-and-cyclic-rgdfk
#9
Andrea J North, John A Karas, Michelle T Ma, Philip J Blower, Uwe Ackermann, Jonathan M White, Paul S Donnelly
This research aimed to develop new tumor targeted theranostic agents taking advantage of the similarities in coordination chemistry between technetium and rhenium. A γ-emitting radioactive isotope of technetium is commonly used in diagnostic imaging, and there are two β(-) emitting radioactive isotopes of rhenium that have the potential to be of use in radiotherapy. Variants of the 6-hydrazinonicotinamide (HYNIC) bifunctional ligands have been prepared by appending thioamide functional groups to 6-hydrazinonicotinamide to form pyridylthiosemicarbazide ligands (SHYNIC)...
August 2, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28759208/correction-to-purification-free-method-for-preparing-technetium-99m-labeled-multivalent-probes-for-enhanced-in-vivo-imaging-of-saturable-systems
#10
Yuki Mizuno, Tomoya Uehara, Hirofumi Hanaoka, Yota Endo, Chun-Wei Jen, Yasushi Arano
No abstract text is available yet for this article.
July 31, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28755732/the-urinothorax-a-comprehensive-review-with-case-series
#11
REVIEW
Adam Austin, Sidharth Navin Jogani, Paul Bradley Brasher, Rahul Gupta Argula, John Terrill Huggins, Amit Chopra
Urinothorax is an uncommon thoracic complication of genitourinary (GU) tract disease, which is most frequently caused by obstructive uropathy, but may also occur as a result of iatrogenic or traumatic GU injury. It is underrecognized because of a perceived notion as to the rarity of the diagnosis and the absence of established diagnostic criteria. Urinothorax is typically described as a paucicellular, transudative pleural effusion with a pleural fluid/serum creatinine ratio >1.0. It is the only transudate associated with pleural fluid acidosis (pH < 7...
July 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28741786/ectopic-parathyroid-adenoma-in-the-pyriform-sinus
#12
Jonathan Kim, Maricel Cubangbang, Lacey Adkins, Stanley Chia, Timothy R DeKlotz, Lisa Boyle, Bruce Davidson
BACKGROUND: Ectopic parathyroid glands may complicate the surgical approach to primary hyperparathyroidism. We describe a rare ectopic parathyroid location, the pyriform sinus. METHODS: Three patients, 2 after prior unsuccessful parathyroid exploration, were found to have ectopic parathyroid adenomas in the pyriform sinus. Two cases were identified by 4D-CT of the neck. The other was localized by a technetium 99m sestamibi single photon emission CT (SPECT). In each case, office endoscopy confirmed the lesions...
July 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28740776/tc-99m-human-serum-albumin-transit-time-as-a-measure-of-arm-breast-cancer-related-lymphedema
#13
Navid M Toyserkani, Svend Hvidsten, Siavosh Tabatabaeifar, Jane A Simonsen, Poul F Høilund-Carlsen, Jens A Sørensen
BACKGROUND: Lymphoscintigraphy has often been used for evaluating arm lymphatic dysfunction, but no optimal approach for quantification has so far emerged. We propose a quantifiable measure of lymphatic function that we applied in patients treated for breast cancer. METHODS: Eleven patients, aged 34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection in both hands of technetium-99m-labeled human serum albumin and sequential 5 min imaging for 5 hours...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28735998/assessment-of-spleen-filtrate-function-in-renal-transplant-recipients-using-technetium-99m-stannous-colloid-liver-spleen-scan
#14
N C Araújo, M B Neves, C A Mandarim-de-Lacerda, M M C Orlando
BACKGROUND: Functional hyposplenism (FH) is indicated by an anatomically present spleen that fails to take up radiolabeled colloid. The occurrence of FH has been reported in a small group of renal transplant recipients based on hematologic parameters. The aim of this study was to replicate this association in a larger group of renal transplant recipients with the use of technetium-99m-stannous colloid liver-spleen scan to assess the spleen function. METHODS: This survey based on single samples enrolled 101 unselected adult patients with functional kidney grafts >180 days after transplantation...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28732555/hepatobiliary-scintigraphy-to-evaluate-liver-function-in-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-liver-volume-overestimates-liver-function
#15
Pim B Olthof, Federico Tomassini, Pablo E Huespe, Stephanie Truant, François-René Pruvot, Roberto I Troisi, Carlos Castro, Erik Schadde, Rimma Axelsson, Ernesto Sparrelid, Roelof J Bennink, Rene Adam, Thomas M van Gulik, Eduardo de Santibanes
BACKGROUND: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) induces a rapid and extensive increase in liver volume. The functional quality of this hypertrophic response has been called into question because ALPPS is associated with a substantial incidence of liver failure and high perioperative mortality. This multicenter study aimed to evaluate functional liver regeneration in contrast to volumetric liver regeneration in ALPPS, using technetium-99m hepatobiliary scintigraphy and computed tomography volumetry, respectively...
July 18, 2017: Surgery
https://www.readbyqxmd.com/read/28728876/is-technetium-99m-sestamibi-imaging-able-to-predict-pathologic-nonresponse-to-neoadjuvant-chemotherapy-in-breast-cancer-a-meta-analysis-evaluating-current-use-and-shortcomings
#16
Angela Collarino, Elizabeth J de Koster, Renato A Valdés Olmos, Lioe-Fee de Geus-Oei, Lenka M Pereira Arias-Bouda
BACKGROUND: Interest in technetium-99m ((99m)Tc)-sestamibi imaging for neoadjuvant chemotherapy (NAC) response monitoring in locally advanced breast cancer (LABC) is increasing but remains matter of discussion. The present study conducted a meta-analysis of the diagnostic performance of (99m)Tc-sestamibi to predict pathologic nonresponse to NAC for primary LABC. MATERIALS AND METHODS: A systematic data search was performed. Studies with a minimum of 10 LABC patients that had evaluated (99m)Tc-sestamibi imaging for NAC nonresponse using conventional planar scintimammography, breast-specific γ-imaging, and/or single photon emission computed tomography/computed tomography (SPECT/CT) were included...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28723715/novel-weight-based-dose-threshold-for-18f-naf-pet-ct-imaging-using-advanced-pet-ct-systems-a-potential-tool-for-reducing-radiation-burden
#17
Fahad Marafi, Abdulreda Esmail, Rashid Rasheed, Fareeda Alkandari, Sharjeel Usmani
BACKGROUND: Fluorine-18-sodium fluoride (F-NaF) PET/CT is an important tool for detecting and evaluating metastatic bone cancer. Besides traditional dose metrics, recent methods such as real-time dose mapping, dose calculation from DICOM information, and their relevance to entrance skin exposure are currently in use to reduce the radiation burden. In this study, we have analyzed the data of 1062 patients retrospectively to evaluate patterns of absorbed dose for institutional weight-based dose protocol as compared with fixed dose method guidelines of Society of Nuclear Medicine and Molecular Imaging (SNMMI)...
July 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28717076/increase-in-the-regional-cerebral-blood-flow-following-waon-therapy-in-patients-with-chronic-fatigue-syndrome-a-pilot-study
#18
Takao Munemoto, Yuji Soejima, Akinori Masuda, Yoshiaki Nakabeppu, Chuwa Tei
Objective Chronic fatigue syndrome (CFS) is a complex disorder, with no consensus on therapeutic options. However, Waon therapy has been reported to be an effective treatment. The purpose of this study was to evaluate changes in the cerebral blood flow (CBF) before and after Waon therapy in CFS patients and to investigate the correlation between such changes and the therapeutic efficacy of Waon therapy. Methods Eleven patients (2 men and 9 women, mean age 27 years old) diagnosed with CFS participated in the study...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715874/detection-of-bacterial-infection-by-a-technetium-99m-labeled-peptidoglycan-aptamer
#19
Iêda Mendes Ferreira, Camila Maria de Sousa Lacerda, Sara Roberta Dos Santos, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Nuclear medicine clinicians are still waiting for the optimal scintigraphic imaging agents capable of distinguishing between infection and inflammation, and between fungal and bacterial infections. Aptamers have several properties that make them suitable for molecular imaging. In the present study, a peptidoglycan aptamer (Antibac1) was labeled with (99m)Tc and evaluated by biodistribution studies and scintigraphic imaging in infection-bearing mice. Labeling with (99m)Tc was performed by the direct method and the complex stability was evaluated in saline, plasma and in the molar excess of cysteine...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28711547/interobserver-variability-for-interpretation-of-dmsa-scans-in-the-rivur-trial
#20
Tej K Mattoo, Steven J Skoog, Lisa Gravens-Mueller, Russell W Chesney, Alejandro Hoberman, Ranjiv Mathews, Marva Moxey-Mims, Anastasia Ivanova, Saul P Greenfield, Myra A Carpenter
INTRODUCTION: Technetium-99m dimercaptosuccinic acid (DMSA) renal scans are used in the diagnosis of renal scarring. In the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial that randomized 607 children, DMSA renal scans were used for evaluating the presence and the severity of renal scarring. OBJECTIVE: The aim was to determine interobserver variability in reporting of DMSA renal scans in the RIVUR trial. STUDY DESIGN: We compared DMSA renal scan reports for renal scarring and acute pyelonephritis from all non-reference local radiologists (ALRs) at study sites with adjudicated as well as non-adjudicated reports from two reference radiologists (RRs) of the RIVUR trial...
June 1, 2017: Journal of Pediatric Urology
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