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Technetium 99m

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https://www.readbyqxmd.com/read/28644197/preoperative-regional-maximal-removal-rate-of-technetium-99m-galactosyl-human-serum-albumin-is-correlated-with-liver-functional-parameters-but-did-not-predict-postoperative-morbidity
#1
Koichi Yano, Atsushi Nanashima, Yoshiro Fujii, Masahide Hiyoshi, Naoya Imamura, Takeomi Hamada, Yuki Tsuchimochi, Takashi Wada, Yoichi Mizutani, Toshinori Hirai
BACKGROUND: Recently, posthepatectomy complications have been predicted by advances of new liver functional parameters, and the technetium-99m-galactosyl human serum albumin (GSA) liver scintigraphy has been applied widely for this purpose. We evaluated the clinical significance of the regional maximal removal rate (GSA-Rmax) in patients with various liver diseases as predictors of posthepatectomy complications. PATIENTS AND METHODS: Between 2012 and March 2016, we examined 200 patients who underwent hepatectomy for liver and biliary diseases...
June 22, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28640526/development-and-characterisation-of-a-99m-tc-tricarbonyl-labelled-estradiol-derivative-obtained-by-click-chemistry-with-potential-application-in-estrogen-receptors-imaging
#2
María Emilia Tejería, Javier Giglio, Silvia Dematteis, Ana Rey
Assessment of the presence of estrogen receptors in breast cancer is crucial for treatment planning. With the objective to develop a potential agent for estrogen receptors imaging we present the development and characterization of a (99m) Tc tricarbonyl labelled estradiol derivative. Using ethinylestradiol as starting material, a estradiol derivative bearing a 1,4-disubstituted 1,2,3-triazole-containing tridentate ligand system was synthesized by "Click Chemistry" and fully characterized. Labelling with high yield and radiochemical purity was achieved through the formation of a (99m) Tc-tricarbonyl complex...
June 22, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28625511/lung-fluid-clearance-in-chronic-heart-failure-patients
#3
Dani-Louise Dixon, Carmine G De Pasquale, Mark D Lawrence, Elena Cavallaro, Vito Rubino, Andrew D Bersten
Chronic elevation of pulmonary microvascular pressure (Pmv) consistently leads to alveolocapillary barrier thickening and reduction in the filtration coefficient. In animal models of chronic heart failure (CHF) the lung remains dry despite hydrostatic forces. As fluid flux is bi-directional, it has been postulated that an increase in alveolar fluid clearance may facilitate the dry lung when Pmv is chronically elevated. In this study we aimed to examine alveolar fluid clearance in ambulatory patients with CHF secondary to left ventricular (LV) systolic dysfunction compared against non-CHF controls...
May 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28624009/measuring-hepatic-functional-reserve-using-t1-mapping-of-gd-eob-dtpa-enhanced-3t-mr-imaging-a-preliminary-study-comparing-with-99m-tc-gsa-scintigraphy-and-signal-intensity-based-parameters
#4
Masataka Nakagawa, Tomohiro Namimoto, Kie Shimizu, Kosuke Morita, Fumi Sakamoto, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Shinya Shiraishi, Yasuyuki Yamashita
PURPOSE: To determine the utility of liver T1-mapping on gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance (MR) imaging for the measurement of liver functional reserve compared with the signal intensity (SI) based parameters, technetium-99m-galactosyl serum albumin ((99m)Tc-GSA) scintigraphy and indocyanine green (ICG) clearance. MATERIALS AND METHODS: This retrospective study included 111 patients (Child-Pugh-A 90; -B 21) performed with both Gd-EOB-DTPA enhanced liver MR imaging and (99m)Tc-GSA (76 patients with ICG)...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28618064/technetium-99m-radiochemistry-for-pharmaceutical-applications
#5
REVIEW
Dionysia Papagiannopoulou
(99m) Tc is a widely used radionuclide and the development of (99m) Tc imaging agents continues to be in demand. This overview discusses basic principles of (99m) Tc radiopharmaceutical preparation and design, and focuses on the technetium-99m radiochemistry relevant to its medical applications. The (99m) Tc complexes are described based on the most typical examples in each category, keeping up with the state-of-the-art in the field. In addition, the main current strategies to develop targeted (99m) Tc radiopharmaceuticals are summarized...
June 15, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28614625/modified-sentinel-lymph-node-technique-combined-with-endoluminal-loco-regional-resection-for-the-treatment-of-rectal-tumors-a-fourteen-year-experience
#6
Silvia Quaresima, Alessandro M Paganini, Giancarlo D'Ambrosio, Pietro Ursi, Andrea Balla, Emanuele Lezoche
AIM: After Endoluminal Loco-Regional Resection (ELRR) by Transanal Endoscopic Microsurgey (TEM) the N parameter may remain undefined. Nucleotide-Guided Mesorectal Excision (NGME) improves the lymph nodes harvest. The aim of the present study is to evaluate the long term oncological results after ELRR with NGME. METHOD: A total of 57 patients were enrolled over the period January 2001 to June 2015.ed. All patients underwent ELRR by TEM. Prior to surgery, 99m-Technetium-marked nanocolloid was injected in the peritumoral submucosa...
June 14, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28612866/technetium-99m-complexes-of-l-arginine-derivatives-for-targeting-amino-acid-transporters
#7
Maurício Morais, Vera F C Ferreira, Flávio Figueira, Filipa Mendes, Paula Raposinho, Isabel Santos, Bruno L Oliveira, João D G Correia
Although relevant from the clinical point of view, radiotracers targeting cationic amino acid transporters are relatively unexplored and, in particular, no metal-based radiotracers are known. The rare examples of complexes recognized by amino acid transporters, namely by the Na(+)-independent neutral l-type amino acid transporter 1 (LAT1), are (99m)Tc(i)/Re(i) compounds. Herein, we describe conjugates comprising a pyrazolyl-diamine chelating unit and the cationic amino acid l-arginine (l-Arg) linked by a propyl (L1) or hexyl linker (L2), which allowed the preparation of stable complexes of the type fac-[(99m)Tc(CO)3(k(3)-L)](+) (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2...
June 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28611846/safety-of-allogeneic-canine-adipose-tissue-derived-mesenchymal-stem-cell-intraspinal-transplantation-in-dogs-with-chronic-spinal-cord-injury
#8
Cláudia Cardoso Maciel Escalhão, Isalira Peroba Ramos, Camila Hochman-Mendez, Tais Hanae Kasai Brunswick, Sergio Augusto Lopes Souza, Bianca Gutfilen, Regina Coeli Dos Santos Goldenberg, Tatiana Coelho-Sampaio
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with (99m)Technetium, and transplanted into the lesion by percutaneous X-ray-guided injection...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28595542/synthesis-of-99mtc-rifabutin-a-potential-tuberculosis-radiodiagnostic-agent
#9
Syed Qaiser Shah, Mamoona Alam
BACKGROUND: Rifabutin (RFN) is bactericidal antibiotic with a very broad spectrum of activity against gram positive & gram negative organisms including Pseudomonas aeruginosa and specifically Mycobacterium tuberculosis. OBJECTIVE: RFN inhibits DNA dependent RNA polymerase activity in susceptible cells. In the instant work, the therapeutic characteristics of RFN were intended for diagnostic rationale by labeling it with 99mTc (Technetium-99m). The 99mTc labeled RFN (99mTc-RFN) was investigated for labeling capacity, steadiness in saline & serum, in vitro Mycobacterium tuberculosis (MBT) uptake & distribution in MBT stained animal model rats...
June 5, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28591006/assessment-of-functional-liver-reserve-old-and-new-in-99mtc-sulfur-colloid-scintigraphy
#10
Manuela M Matesan, Stephen R Bowen, Tobias R Chapman, Robert S Miyaoka, James W Velez, Michele F Wanner, Matthew J Nyflot, Smith Apisarnthanarax, Hubert J Vesselle
PURPOSE: A semiquantitative assessment of hepatic reticuloendothelial system function using colloidal particles scintigraphy has been proposed previously as a surrogate for liver function evaluation. In this article, we present an updated method for the overall assessment of technetium-99m (Tc)-sulfur colloid (SC) biodistribution that combines information from planar and attenuation-corrected Tc-SC single-photon emission computed tomography (SPECT) images. The imaging protocol described here was developed as an easy-to-implement method to assess overall and regional liver function changes associated with chronic liver disease...
June 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28584569/angiographic-diagnosis-of-meckel-s-diverticulum-in-an-adult-patient-with-negative-scintigraphy
#11
Mark Kovacs, Jonathan Botstein, Stuart Braverman
A Meckel's diverticulum was diagnosed by mesenteric angiography in a 34 year-old patient who presented with hematochezia and dropping hemoglobin. The case demonstrates the challenges often encountered in workup of occult gastrointestinal (GI) bleeding, and shows that angiographic diagnosis of Meckel's diverticulum is possible, even in the absence of angiographic evidence of active extravasation. Our patient had a previous non-diagnostic workup including upper and lower endoscopy, videocapsulography, and Technetium-99m pertechnetate (Tc-99m) scintigraphy...
March 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/28584413/idiopathic-condylar-resorption-the-current-understanding-in-diagnosis-and-treatment
#12
REVIEW
Andrew Young
Idiopathic condylar resorption (ICR) is a condition with no known cause, which manifests as progressive malocclusion, esthetic changes, and often pain. Cone-beam computed tomography and magnetic resonance imaging are the most valuable imaging methods for diagnosis and tracking, compared to the less complete and more distorted images provided by panoramic radiographs, and the higher radiation of (99m)technetium-methylene diphosphonate. ICR has findings that overlap with osteoarthritis, inflammatory arthritis, physiologic resorption/remodeling, congenital disorders affecting the mandible, requiring thorough image analysis, physical examination, and history-taking...
April 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28583518/cystatin-c-based-equation-for-predicting-the-glomerular-filtration-rate-in-kidney-transplant-recipients
#13
Y Yang, K Y Kim, I Hwang, T Yim, W Do, M J Kim, S Lee, H-Y Jung, J-Y Choi, S-H Park, Y-L Kim, C-D Kim, J-H Cho
BACKGROUND: Precise monitoring of the glomerular filtration rate (GFR) is needed to estimate the allograft function in kidney transplant recipients (KTRs). The GFR is widely estimated with the use of formulas based on serum cystatin C (SCys) and serum creatinine (SCr) levels. We compared the efficacy of SCys-based equations with that of SCr-based equations to predict the allograft function. METHODS: We calculated the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI Cr), CKD-EPI creatinine-cystatin C (CKD-EPI Cr/Cys), and CKD-EPI cystatin C (CKD-EP ICys) equations in 70 KTRs...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28579328/the-evaluations-of-99m-tc-cyclopentadienyl-tricarbonyl-triphenyl-phosphonium-cation-for-multidrug-resistance
#14
Shuting Chen, Ying Zhang, Xiaoyan Li, Hongmei Jia, Jie Lu
A triphenylphosphonium cation, [(99m)Tc]Technetium cyclopentadienyltricarbonyl-6-hexanoyl-triphenylphosphonium cation ([(99m)Tc]3) was prepared to target multidrug resistance (MDR). The radiotracer was evaluated in the MDR-negative MCF-7 and MDR-positive MCF-7/ADR cell lines in vitro, as well as animal models in vivo. [(99m)Tc]3 was proofed to be a substrate of P-glycoprotein and multidrug resistant protein 1, and showed a higher accumulation in the MDR-negative MCF-7 cells compared to (99m)Tc-sestamibi in vitro...
May 17, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28573537/derivation-of-new-equations-to-estimate-glomerular-filtration-rate-in-pediatric-oncology-patients
#15
Vanessa E Millisor, Jessica K Roberts, Yilun Sun, Li Tang, Vinay M Daryani, David Gregornik, Shane J Cross, Deborah Ward, Jennifer L Pauley, Alejandro Molinelli, Rachel C Brennan, Clinton F Stewart
BACKGROUND AND OBJECTIVE: Monitoring renal function is critical in treating pediatric patients, especially when dosing nephrotoxic agents. We evaluated the validity of the bedside Schwartz and Brandt equations in pediatric oncology patients and developed new equations for estimated glomerular filtration rate (eGFR) in these patients. METHODS: A retrospective analysis was conducted comparing eGFR using the bedside Schwartz and Brandt equations to measured GFR (mGFR) from technetium-99m diethylenetriamine pentaacetic acid ((99m)Tc-DTPA) between January 2007 and August 2013...
June 2, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28571944/indocyanine-green-versus-radiotracer-%C3%A2-blue-dye-for-sentinel-lymph-node-mapping-in-stage-ib1-cervical-cancer-2-cm
#16
Giampaolo Di Martino, Cinzia Crivellaro, Elena De Ponti, Beatrice Bussi, Andrea Papadia, Ignacio Zapardiel, Enrico Vizza, Federica Elisei, Maria Dolores Diestro, Luca Locatelli, Maria Luisa Gasparri, Paolo Di Lorenzo, Michael Mueller, Alessandro Buda
STUDY OBJECTIVE: To compare sentinel lymph node (SLN) mapping in women with cervical cancer stage > IB1 (tumor > 2 cm) by using indocyanine green (ICG) versus the standard radioisotope technetium 99m radiocolloid (Tc99(m)) radiotracer ± blue-dye technique. DESIGN: European multicenter, retrospective observational study (Canadian Task Force Classification II-2) SETTING: Four academic medical centers PATIENTS: 95 women with stage IB1 (> 2 cm) who underwent SLN mapping with Tc99(m) ± blue dye or ICG and radical hysterectomy INTERVENTION: Detection rate and bilateral mapping rate of ICG were compared with those obtained using the standard Tc99(m) radiotracer ± blue dye...
May 29, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28555448/new-synthesis-route-of-active-substance-d-l-hmpao-for-preparation-technetium-tc99m-exametazime
#17
Justyna Pijarowska-Kruszyna, Urszula Karczmarczyk, Antoni Włodzimierz Jaroń, Ewa Laszuk, Marcin Radzik, Piotr Garnuszek, Renata Mikołajczak
BACKGROUND: Technetium Tc99m Exametazime (99mTc-HMPAO) is currently used as a radiopharmaceutical for determining regional cerebral blood flow and for the labelling of autologous leucocytes for infection and inflammation imaging. The HMPAO ligand exists in two diastereomeric forms: d,l and meso. Usually, the substance is obtained in low chemical yield in a time consuming procedure. Furthermore, the final product still contains some amounts of the meso-form. The aim of this study was to develop the efficient, reliable and fast method for isolation of the d,l-HMPAO, which would provide the ligand with high purity and free from the meso-diastereomer...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28553184/initial-experience-in-the-use-of-technetium-99-metastable-hydroxymethylene-diphosphonate-as-an-alternative-ventilation-agent-during-periods-of-interim-shortage
#18
Colin Raymond Young, Kalpna Prasad
Sporadic supply interruptions of select radiopharmaceuticals on the global market require consideration of alternative agents to support continuity of essential nuclear medicine examinations. During an acute shortage of Xenon-133 and technetium-99 metastable (Tc-99m) diethylene-triamine-pentaacetate (DTPA), our institution used aerosolized Tc-99m hydroxymethylene diphosphonate (HDP), a radiopharmaceutical traditionally used in bone scintigraphy, in lieu of traditional ventilation agents, for two cases of suspected pulmonary embolism...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553179/peptide-receptor-radionuclide-therapy-with-177-lu-dotatate-for-metastatic-neuroendocrine-tumor-occurring-in-association-with-multiple-endocrine-neoplasia-type-1-and-cushing-s-syndrome
#19
Chinna Naik, Sandip Basu
Neuroendocrine tumor (NET) occurring in association with other endocrine syndromes forms a distinct entity. The aim was to assess the therapy response profile of the routine peptide receptor radionuclide therapy (PRRT) in this relatively uncommon but clinically challenging subgroup of patients. A retrospective analysis was undertaken from the case records from those who were treated with (177)Lu-DOTATATE for metastatic NET. In addition to assessing the therapeutic efficacy, emphasis was also given to study lesional sites and scan pattern...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553174/technetium-99m-methylene-diphosphonate-single-photon-emission-computed-tomography-computed-tomography-of-the-foot-and-ankle
#20
REVIEW
Bhavin Upadhyay, Jonathan Mo, Clare Beadsmoore, Tom Marshall, Andoni Toms, John Buscombe
The complex anatomy and function of the foot and ankle can make it difficult to determine the cause of symptoms in patients with foot and ankle pathology. Following initial clinical and radiographic assessment, additional imaging with magnetic resonance imaging may be required, which is often seen as the modality of choice. Although sensitive to pathological changes in bone metabolism and vascularity, technetium-99m (Tc-99m) bone scintigraphy often lacks the specificity and resolution required to evaluate the structures of the foot and ankle...
April 2017: World Journal of Nuclear Medicine
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