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Technetium 99m

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https://www.readbyqxmd.com/read/29785109/development-and-characterization-of-a-nanoemulsion-containing-propranolol-for-topical-delivery
#1
Tatiana Zanela da Silva Marques, Ralph Santos-Oliveira, Luciana Betzler de Oliveira de Siqueira, Verônica da Silva Cardoso, Zaida Maria Faria de Freitas, Rita de Cássia da Silva Ascenção Barros, Ana Lúcia Vazquez Villa, Mariana Sato de Souza de Bustamante Monteiro, Elisabete Pereira Dos Santos, Eduardo Ricci-Junior
Background: Propranolol (PPN) is a therapeutic option for the treatment of infantile hemangiomas. This study aimed at the development of nanoemulsion (NE) containing 1% PPN, characterization of the system, and safety studies based on ex vivo permeation, cytotoxicity, and biodistribution in vivo. Methods: The formulation was developed and characterized in relation to the droplet size, polydispersity index (PDI), pH, zeta potential, and electronic microscopy. Ex vivo permeation studies were used to evaluate the cutaneous retention of PPN in the epidermis and dermis...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29778927/evaluation-of-99m-tc-sulfonamide-and-sulfocoumarin-derivatives-for-imaging-carbonic-anhydrase-ix-expression
#2
Misaki Nakai, Jihne Pan, Kuo-Shyan Lin, John R Thompson, Alessio Nocentini, Claudiu T Supuran, Yasuo Nakabayashi, Tim Storr
With the aim to prepare hypoxia tumor imaging agents, technetium(I) and rhenium(I) tricarbonyl complexes with dipyridylamine (L1 = N-{[1-(2,2-dioxido-1,2-benzoxathiin-6-yl)-1H-1,2,3-triazol-4-yl]methyl}-N-(2-pyridinylmethyl)-2-pyridinemethanamine; L3 = N-{[1-[N-(4-aminosulfonylphenyl)]-1H-1,2,3-triazol-4-yl]methyl}-N-(2-pyridinyl-methyl)-2-pyridinemethanamine), and iminodiacetate (H2 L2 = N-{[1-(2,2-dioxido-1,2-benzoxathiin-6-yl)-1H-1,2,3-triazole-4-yl]methyl}-N-(carboxy-methyl)-glycine; H2 L4 = N-{[1-[N-(4-aminosulfonylphenyl)]-1H-1,2,3-triazole-4-yl]methyl}-N-(carboxymethyl)-glycine) ligands appended to sulfonamide or sulfocoumarin carbonic anhydrase inhibitors were synthesized...
April 13, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29777899/congenital-dyshormonogenic-hypothyroidism-with-goiter-caused-by-a-sodium-iodide-symporter-slc5a5-mutation-in-a-family-of-shih-tzu-dogs
#3
E A Soler Arias, V A Castillo, J D Garcia, J C Fyfe
An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. The only sign of hypothyroidism was a moderate growth delay in the adult dog. The ITD was recognized by the absence of uptake of technetium-99m in the salivary glands (sg) and goiter observed by scintigraphy. In the same scan, radiopharmaceutical uptake was found in the anterior mediastinum of both dogs and in the right axillary lymph node in the oldest dog...
April 24, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29766779/technetium-99m-based-radiopharmaceuticals-in-sentinel-lymph-node-biopsy-gynecologic-oncology-perspective
#4
Kamil Zalewski, Malgorzata Benke, Bartlomiej Mirocha, Jakub Radziszewski, Magdalena Chechlinska, Magdalena Kowalewska
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN involvement benefit from extensive lymphadenectomy in terms of prolonged survival. Moreover, overtreatment of patients with localized disease carries unnecessary risk of complications...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29763366/right-ventricle-performances-with-echocardiography-and-99m-tc-myocardial-perfusion-imaging-in-pulmonary-arterial-hypertension-patients
#5
Jie Liu, Lei Fei, Guang-Qing Huang, Xiao-Ke Shang, Mei Liu, Zhi-Jun Pei, Yong-Xue Zhang
Right heart catheterization is commonly used to measure right ventricle hemodynamic parameters and is the gold standard for pulmonary arterial hypertension diagnosis; however, it is not suitable for patients' long-term follow-up. Non-invasive echocardiography and nuclear medicine have been applied to measure right ventricle anatomy and function, but the guidelines for the usefulness of clinical parameters remain to be established. The goal of this study is to identify reliable clinical parameters of right ventricle function in pulmonary arterial hypertension patients and analyze the relationship of these clinical parameters with the disease severity of pulmonary arterial hypertension...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29761277/treatment-of-differentiated-thyroid-cancer-can-endoscopic-thyroidectomy-via-a-chest-breast-approach-achieve-similar-therapeutic-effects-as-open-surgery
#6
Rui Qu, Jinyi Li, Jingge Yang, Peng Sun, Jian Gong, Cunchuan Wang
BACKGROUND: An analysis of some special factors was performed to further evaluate and discuss whether endoscopic surgery and traditional open surgery have similar therapeutic outcomes for differentiated thyroid cancer (DTC). METHODS: A retrospective study was performed on 76 patients undergoing surgery to treat DTC. Forty patients were treated by endoscopic thyroidectomy via the chest-breast approach (endoscopic group) and thirty-six patients were treated by open surgery (open group)...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29756115/severe-decrease-in-spo-2-and-methemoglobinemia-following-subareolar-isosulfan-blue-administration-and-clinical-relevance
#7
Esra Yüksel, Dilek Duman, Levent Yeniay, Sezgin Ulukaya
The level of axillary lymph node involvement in breast cancer is a critical decision factor for adjuvant therapy and the most important indicator of prognosis and survival. Sentinel lymph node biopsy is a minimally invasive technique with low morbidity in axillary staging of breast cancer. Radiocolloid substances (Technetium-99m) and/or blue dyes such as methylene blue or isosulfan blue are used during sentinel lymph node biopsy. Isosulfan blue stain is frequently used in sentinel lymph node biopsy and rarely causes complications...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29750878/perfusion-scintigraphy-in-the-assessment-of-autologous-cell-therapy-in-diabetic-patients-with-critical-limb-ischemia
#8
A Nemcova, A Jirkovska, M Dubsky, R Bem, V Fejfarova, V Woskova, A Pysna, M Buncova
Perfusion scintigraphy with technetium-99-methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) is often used for assessing myocardial function but the number of studies concerning lower limb perfusion is limited. The aim of our study was to assess whether (99m)Tc-MIBI was an eligible method for evaluation of the effect of cell therapy on critical limb ischemia (CLI) in diabetic patients. (99m)Tc-MIBI of calf muscles was performed before and 3 months after autologous cell therapy (ACT) in 24 diabetic patients with CLI...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29748311/radiotracer-imaging-allows-for-noninvasive-detection-and-quantification-of-abnormalities-in-angiosome-foot-perfusion-in-diabetic-patients-with-critical-limb-ischemia-and-nonhealing-wounds
#9
Jessica L Alvelo, Xenophon Papademetris, Carlos Mena-Hurtado, Sangchoon Jeon, Bauer E Sumpio, Albert J Sinusas, Mitchel R Stacy
BACKGROUND: Single photon emission computed tomography (SPECT)/computed tomography (CT) imaging allows for assessment of skeletal muscle microvascular perfusion but has not been quantitatively assessed in angiosomes, or 3-dimensional vascular territories, of the foot. This study assessed and compared resting angiosome foot perfusion between healthy subjects and diabetic patients with critical limb ischemia (CLI). Additionally, the relationship between SPECT/CT imaging and the ankle-brachial index-a standard tool for evaluating peripheral artery disease-was assessed...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29742312/semi-quantitative-methods-yield-greater-inter-and-intraobserver-agreement-than-subjective-methods-for-interpreting-99m-technetium-hydroxymethylene-diphosphonate-uptake-in-equine-thoracic-processi-spinosi
#10
Claudia van Zadelhoff, Anna Ehrle, Roswitha Merle, Werner Jahn, Christoph Lischer
Scintigraphy is a standard diagnostic method for evaluating horses with back pain due to suspected thoracic processus spinosus pathology. Lesion detection is based on subjective or semi-quantitative assessments of increased uptake. This retrospective, analytical study is aimed to compare semi-quantitative and subjective methods in the evaluation of scintigraphic images of the processi spinosi in the equine thoracic spine. Scintigraphic images of 20 Warmblood horses, presented for assessment of orthopedic conditions between 2014 and 2016, were included in the study...
May 9, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29724381/pulmonary-deposition-of-fluticasone-propionate-formoterol-in-healthy-volunteers-asthmatics-and-copd-patients-with-a-novel-breath-triggered-inhaler
#11
Dominik Kappeler, Knut Sommerer, Claudius Kietzig, Bärbel Huber, Jo Woodward, Mark Lomax, Prashant Dalvi
INTRODUCTION: A combination of fluticasone propionate/formoterol fumarate (FP/FORM) has been incorporated within a novel, breath-triggered device, named K-haler® . This low resistance device requires a gentle inspiratory effort to actuate it, triggering at an inspiratory flow rate of approximately 30 L/min; thus avoiding the need for coordination of inhalation with manual canister depression. The aim of the study was to evaluate total and regional pulmonary deposition of FP/FORM when administered via the K-haler device...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29705817/application-of-the-alteration-uptake-ratio-of-99m-tc-mibi-scintigraphy-for-evaluating-the-efficacy-of-neoadjuvant-chemotherapy-in-osteosarcoma-patients
#12
Zhongke Huang, Cen Lou
BACKGROUND: We aimed to semi-quantitatively evaluate using technetium-99m methoxyisobutylisonitrile (99m Tc-MIBI) scintigraphy the efficacy of neoadjuvant chemotherapy in osteosarcoma (OS) patients. SUBJECTS AND METHODS: A hundred and two patients with OS were retrospectively included in this study. All of them underwent 99m Tc-MIBI scintigraphy before and after neoadjuvant chemotherapy. Semi-quantitative parameters including the uptake ratio (UR) and alteration of uptake ratio (AUR) were calculated for each patient...
January 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29703018/multiple-unexpected-lesions-of-metachondromatosis-detected-by-technetium-99m-methylene-diphosphonate-spect-ct-a-case-report
#13
Zi Wang, Yuting Zou, Yu Chen, Yue Chen
RATIONALE: Metachondromatosis (MC) is a very rare genetic disease, which is infrequently reported worldwide, which leads to osteochondroma and enchondromatosis. The disease has been shown to be associated with loss of function of the tumor suppressor gene "protein tyrosine phosphatase, non-receptor type 11" (PTPN11). PATIENT CONCERNS: A 12-year-old female was admitted to the hospital with pain due to an enlarged mass in her left fifth finger. DIAGNOSIS: Examination of the left hand by computed tomography (CT) revealed an expanding type of round and low-density lesion in the fifth proximal phalanx...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29682892/template-free-fabrication-of-mesoporous-alumina-nanospheres-using-post-synthesis-water-ethanol-treatment-of-monodispersed-aluminium-glycerate-nanospheres-for-molybdenum-adsorption
#14
Indra Saptiama, Yusuf Valentino Kaneti, Yoshitaka Suzuki, Kunihiko Tsuchiya, Nobuyoshi Fukumitsu, Takeji Sakae, Jeonghun Kim, Yong-Mook Kang, Katsuhiko Ariga, Yusuke Yamauchi
This work reports the template-free fabrication of mesoporous Al2 O3 nanospheres with greatly enhanced textural characteristics through a newly developed post-synthesis "water-ethanol" treatment of aluminium glycerate nanospheres followed by high temperature calcination. The proposed "water-ethanol" treatment is highly advantageous as the resulting mesoporous Al2 O3 nanospheres exhibit 2-4 times higher surface area (up to 251 m2 g-1 ), narrower pore size distribution, and significantly lower crystallization temperature than those obtained without any post-synthesis treatment...
April 22, 2018: Small
https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#15
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29659318/synthesis-characterization-radiolabeling-and-biodistribution-of-a-novel-cyclohexane-dioxime-derivative-as-a-potential-candidate-for-tumor-imaging
#16
M A Motaleb, Adli A Selim, M El-Tawoosy, M H Sanad, M A El-Hashash
PURPOSE: dioxime derivative is reported to exhibit high affinity towards tumor cells. The objective of the present study is to synthesis a new dioxime derivative to be labeled with technetium-99m for using as solid tumor marker. MATERIALS AND METHODS: ((2E,2'E,3E,3'E)-3,3'-(cyclohexane-1,2-diylbis (azanylylidene)) bis-(butan-2-one)dioxime was synthesized by condensation of Butan-2,3-dione monooxime and diaminocyclohexane and labeled with 99m Tc, The in-vivo distribution of the agent were studied by carrying out biodistribution in tumor bearing Albino mice...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#17
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29643673/incomplete-form-of-primary-hypertrophic-osteoarthropathy-touraine-solente-gole-syndrome-masquerading-as-polyartrhalgia-diagnosed-in-technetium-99m-methylene-diphosphonate-scintigraphy-an-interesting-case-report
#18
Thangalakshmi Sivathapandi, Jaykanth Amalachandran, Shelley Simon, Indirani Elangovan
The primary hypertrophic osteoarthropathy (PHOA) (pachydermoperiostosis) is a rare genetic/hereditary disease characterized by skin changes (pachydermia), clubbing of fingers and periosteal thickening (periostitis) with sub-periosteal new bone formation. Here we describe a case of an adolescent male who presented with clubbing and polyarthralgia. On evaluation with scintigraphy and SPECT-CT, he was diagnosed to have incomplete form of PHOA(skeletal manifestations without skin changes). The identification of incomplete form of primary hypertrophic osteoarthropathy which can be easily misdiagnosed as rheumatoid arthritis is discussed here...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29625755/-99m-technetium-based-prostate-specific-membrane-antigen-radioguided-surgery-in-recurrent-prostate-cancer
#19
Tobias Maurer, Stephanie Robu, Margret Schottelius, Kristina Schwamborn, Isabel Rauscher, Nynke S van den Berg, Fijs W B van Leeuwen, Bernhard Haller, Thomas Horn, Matthias M Heck, Jürgen E Gschwend, Markus Schwaiger, Hans-Jürgen Wester, Matthias Eiber
BACKGROUND: Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) can visualize metastatic lesions in recurrent prostate cancer (PC). However, reliable identification of small and/or atypically localized lesions during salvage surgery procedures is challenging. OBJECTIVE: To describe the technique, feasibility, and short-term outcomes of99m Technetium (99m Tc)-based PSMA-radioguided surgery (99m Tc-PSMA-RGS) for removal of recurrent PC lesions...
April 3, 2018: European Urology
https://www.readbyqxmd.com/read/29618443/labeling-of-epirubicin-with-technetium-99m-optimization-biodistribution-and-scintigraphic-imaging-in-tumor-bearing-mice
#20
Saira Hina, Tanveer Hussain Bokhari, Samina Roohi, Muhammad Ibrahim Rajoka, Muhammad Sohaib
Epirubicin is an antineoplastic agent of anthracycline antibiotic, used for treating a variety of tumor types such as lymphoma, cancer of the breast, lung, ovary and stomach. The objective of this work was to demonstrate direct radiolabeling of epirubicin with99m Tc, quality control, biological characterization and scientigraphic evaluation in tumor bearing mice. The 99mTc-epirubicin labeling was optimized by varying the amounts of ligand 100-350μg, stannous chloride dihydride 20-50μg and pH range 2-10 by using NaOH or HCl...
March 2018: Pakistan Journal of Pharmaceutical Sciences
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