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Gadolinium deposition

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https://www.readbyqxmd.com/read/28890973/highly-dispersed-ultra-small-pd-nanoparticles-on-gadolinium-hydroxide-nanorods-for-efficient-hydrogenation-reactions
#1
Naseeb Ullah, M Imran, Kuang Liang, Cheng-Zong Yuan, Akif Zeb, Nan Jiang, Umair Yaqub Qazi, Shafaq Sahar, An-Wu Xu
Heterogeneous catalytic hydrogenation reactions are of great importance to the petrochemical industry and fine chemical synthesis. Herein, we present the first example of gadolinium hydroxide (Gd(OH)3) nanorods as a support for loading ultra-small Pd nanoparticles for hydrogenation reactions. Gd(OH)3 possesses a large number of hydroxyl groups on the surface, which act as an ideal support for good dispersion of Pd nanoparticles. Gd(OH)3 nanorods are prepared by hydrothermal treatment, and Pd/Gd(OH)3 catalyst with a low loading of 0...
September 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28881830/value-of-quantitative-magnetic-resonance-imaging-t1-relaxometry-in-predicting-contrast-enhancement-in-glioblastoma-patients
#2
Elke Hattingen, Andreas Müller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Ulrich Herrlinger, Martin Glas, Sied Kebir
SUMMARIZING THE IMPORTANCE OF THE STUDY: The repetitive usage of gadolinium-based contrast agents (GBCA) is critical for magnetic resonance imaging (MRI) evaluation of tumor burden in glioblastoma patients. It is also a crucial tool for determination of radiographical response to treatment. GBCA injection, however, comes with a 2.4% rate of adverse events including life-threatening conditions such as nephrogenic systemic fibrosis (NSF). Moreover, GBCA have been shown to be deposited in brain tissue of patients even with an intact blood-brain barrier (BBB)...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28859167/up-to-52-administrations-of-macrocyclic-ionic-mr-contrast-agent-are-not-associated-with-intracranial-gadolinium-deposition-multifactorial-analysis-in-385-patients
#3
Ji Ye Lee, Ji Eun Park, Ho Sung Kim, Seon-Ok Kim, Joo Young Oh, Woo Hyun Shim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim
PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, 385 consecutive patients who underwent MICA-enhanced MR imaging were enrolled. The dentate nucleus-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) signal intensity (SI) ratios on unenhanced T1-weighted images were recorded by 2 independent readers and averaged...
2017: PloS One
https://www.readbyqxmd.com/read/28842186/an-altered-blood-brain-barrier-contributes-to-brain-iron-accumulation-and-neuroinflammation-in-the-6-ohda-rat-model-of-parkinson-s-disease
#4
Sonia Olmedo-Díaz, Héctor Estévez-Silva, Greger Orädd, Sara Af Bjerkén, Daniel Marcellino, Ana Virel
Brain iron accumulation is a common feature shared by several neurodegenerative disorders including Parkinson's disease. However, what produces this accumulation of iron is still unknown. In this study, the 6-hydroxydopamine (6-OHDA) hemi-parkinsonian rat model was used to investigate abnormal iron accumulation in substantia nigra. We investigated three possible causes of iron accumulation; a compromised blood-brain barrier (BBB), abnormal expression of ferritin, and neuroinflammation. We identified alterations in the BBB subsequent to the injection of 6-OHDA using gadolinium-enhanced magnetic resonance imaging (MRI)...
August 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28832339/coherent-normalization-for-i-in-vivo-i-measurements-of-gadolinium-in-bone
#5
Zaid Keldani, Michelle L Lord, Fiona E McNeill, David R Chettle, James L Gräfe
Recent evidence of gadolinium (Gd) deposition in bones of healthy individuals who have previously received Gd-based contrast agents (GBCAs) for MRI, has led to a demand for in vivo measurement techniques. The technique of x-ray fluorescence (XRF) provides a low risk and painless method to assess Gd deposition in bone, and has the potential to be a useful clinical tool. However, interpatient variability creates a challenge while performing in vivo measurements. We explored the use of coherent normalization, which involves normalizing the Gd K x-rays to the coherent scattered gamma-ray from the excitation source, for bone Gd measurements through a series of phantom-based experiments and Monte Carlo simulations...
August 23, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28825888/ten-things-you-might-not-know-about-iron-oxide-nanoparticles
#6
REVIEW
Heike E Daldrup-Link
Amid mounting concerns about nephrogenic sclerosis and gadolinium deposition in the brain, physicians and patients alike are starting to question the use of gadolinium chelates for clinical magnetic resonance (MR) imaging. The search for safer alternatives is currently underway. In North America, the iron supplement ferumoxytol has gained considerable interest as an MR contrast agent. In Europe, ferumoxtran-10 is entering phase III clinical trials. As these agents are starting to be used by a new generation of radiologists, important clinical questions have re-emerged, including those that have been answered in the past...
September 2017: Radiology
https://www.readbyqxmd.com/read/28801077/myocardial-amyloid-quantification-with-look-locker-magnetic-resonance-sequence-in-cardiac-amyloidosis-diagnostic-accuracy-in-clinical-practice-and-histological-validation
#7
Eduardo Pozo, Jose M Castellano, Anubhav Kanwar, Rajiv Deochand, Mireia Castillo-Martin, Pablo Pazos-López, Carlos González-Lengua, Keren Osman, Matthew Cham, Carlos Cordon-Cardo, Jagat Narula, Valentin Fuster, Javier Sanz
BACKGROUND: Cardiac magnetic resonance (CMR) has demonstrated its utility in the non-invasive diagnosis of cardiac amyloidosis (CA). Our aim was to evaluate the ability of standard Look-Locker sequences to quantify amyloid deposition in CA. METHODS AND RESULTS: Consecutive patients referred for CMR for possible CA were retrospectively evaluated. Positive cardiac biopsy and/or typical pattern of late gadolinium enhancement were required for the diagnosis of CA. Post-contrast T1 values were obtained from Look-Locker sequences, and correlated with markers of severity of disease and major events...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28782941/integrating-aln-with-gdn-thin-films-in-an-in-situ-cvd-process-influence-on-the-oxidation-and-crystallinity-of-gdn
#8
Stefan Cwik, Sebastian M J Beer, Stefanie Hoffmann, Michael Krasnopolski, Detlef Rogalla, Hans-Werner Becker, Daniel Peeters, Andreas Ney, Anjana Devi
The application potential of rare earth nitride (REN) materials has been limited due to their high sensitivity to air and moisture leading to facile oxidation upon exposure to ambient conditions. For the growth of device quality films, physical vapor deposition methods, such as molecular beam epitaxy, have been established in the past. In this regard, aluminum nitride (AlN) has been employed as a capping layer to protect the functional gadolinium nitride (GdN) from interaction with the atmosphere. In addition, an AlN buffer was employed between a silicon substrate and GdN serving as a seeding layer for epitaxial growth...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28767656/collagen-turnover-biomarkers-and-systemic-right-ventricle-remodeling-in-adults-with-previous-atrial-switch-procedure-for-transposition-of-the-great-arteries
#9
Magdalena Lipczyńska, Piotr Szymański, Magdalena Kumor, Anna Klisiewicz, Piotr Hoffman
BACKGROUND: Myocardial fibrosis is a potential pathophysiological mechanism leading to systemic right ventricular (SRV) deterioration. We hypothesize that circulating levels of collagen deposition markers are elevated in patients with SRV remodeling and this elevation may have a predictive value. METHODS: We prospectively evaluated 56 patients with D-TGA after the atrial switch procedure (mean age 25.6 ± 4.8, range 18-37 years; 67% males). Serum levels of procollagen type III amino-terminal propeptide (PIIINP), collagen type I carboxy-terminal telopeptide (CITP), procollagen type I N-terminal propeptide (PINP), matrix metalloproteinase (MMP 1, MMP 9) and a tissue inhibitor of matrix metalloproteinase (TIMP 1) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were measured and compared with healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28749164/distribution-and-chemical-forms-of-gadolinium-in-the-brain-a-review
#10
Tomonori Kanda, Yudai Nakai, Akifumi Hagiwara, Hiroshi Oba, Keiko Toyoda, Shigeru Furui
In the 3 years since residual gadolinium-based contrast agent (GBCA) in the brain was first reported, much has been learned about its accumulation, including the pathway of GBCA entry into the brain, the brain distribution of GBCA, and its excretion. Here we review recent progress in understanding the routes of gadolinium deposition in brain structures.
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28744073/gadolinium-based-contrast-agents-in-current-practice-risks-of-accumulation-and-toxicity-in-patients-with-normal-renal-function
#11
Anju Ranga, Yatish Agarwal, Kanika J Garg
Despite being decked as the most prized compounds in the nugget box of contrast agents for clinical radiologists, and carrying an indisputable tag of safety of the US Food and Drug Administration for close to three decades, all may not be seemingly well with the family of gadolinium compounds. If the first signs of violations of primum non nocere in relation to gadolinium-based contrast agents (GBCAs) appeared in the millennium year with the first published report of skin fibrosis in patients with compromised renal function, the causal relationship between the development of nephrogenic systemic fibrosis (NSF) and GBCAs, first proposed by two European groups in 2006, further precluded their use in renocompromised patients...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28712826/induction-of-skeletal-abnormalities-and-autophagy-in-paracentrotus-lividus-sea-urchin-embryos-exposed-to-gadolinium
#12
Chiara Martino, Roberto Chiarelli, Liana Bosco, Maria Carmela Roccheri
Gadolinium (Gd) concentration is constantly increasing in the aquatic environment, becoming an emergent environmental pollutant. We investigated the effects of Gd on Paracentrotus lividus sea urchin embryos, focusing on skeletogenesis and autophagy. We observed a delay of biomineral deposition at 24 hours post fertilization (hpf), and a strong impairment of skeleton growth at 48 hpf, frequently displayed by an asymmetrical pattern. Skeleton growth was found partially resumed in recovery experiments. The mesodermal cells designated to biomineralization were found correctly migrated at 24 hpf, but not at 48 hpf...
July 6, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28696174/bilateral-lateral-ventricular-subependymoma-with-extensive-multiplicity-presenting-with-hemorrhage
#13
F M Moinuddin, Novita Ikbar Khairunnisa, Hirofumi Hirano, Tomoko Hanada, Tsubasa Hiraki, Mari Kirishima, Kiyohisa Kamimura, Kazunori Arita
This 48-year-old-man who had undergone right thyroid lobectomy for undifferentiated thyroid carcinoma nine years earlier developed generalized seizures. His cerebrospinal fluid was xanthochromic with elevation of total protein. Computed tomography (CT) showed mixed-density bilateral ventricular masses. Magnetic resonance imaging (MRI) revealed multiple nodules in both lateral ventricles; they were heterogeneously enhanced by gadolinium. Diffuse hyperintensity in the right medial temporal lobe and bilateral subependymal area was noted on fluid-attenuated inversion recovery images...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28691526/non-enhanced-versus-low-dose-contrast-enhanced-renal-magnetic-resonance-angiography-at-7-t-a-feasibility-study
#14
Anja Laader, Karsten Beiderwellen, Oliver Kraff, Stefan Maderwald, Mark E Ladd, Michael Forsting, Lale Umutlu
Background Considering the currently reported association between a repetitive application and cumulative dosage of Gadolinium (Gd)-based contrast agents and Gd-deposition in brain tissue as well as the risk for the advent of nephrogenic systemic fibrosis (NSF), techniques allowing for a dose reduction become an important key aspect aside from non-enhanced magnetic resonance angiography (MRA) techniques. Thus, this study was focused on the reduction and/or complete omission of contrast agent for renal MRA at 7T...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28687012/value-of-quantitative-magnetic-resonance-imaging-t1-relaxometry-in-predicting-contrast-enhancement-in-glioblastoma-patients
#15
Elke Hattingen, Andreas Müeller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Ulrich Herrlinger, Martin Glas, Sied Kebir
The repetitive usage of gadolinium-based contrast agents (GBCA) is critical for magnetic resonance imaging (MRI) evaluation of tumor burden in glioblastoma patients. It is also a crucial tool for determination of radiographical response to treatment. GBCA injection, however, comes with a 2.4% rate of adverse events including life-threatening conditions such as nephrogenic systemic fibrosis (NSF). Moreover, GBCA have been shown to be deposited in brain tissue of patients even with an intact blood-brain barrier (BBB)...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28657418/chemically-defined-camelid-antibody-bioconjugate-for-the-magnetic-resonance-imaging-of-alzheimer-s-disease
#16
Matthias Vandesquille, Tengfei Li, Chrystelle Po, Christelle Ganneau, Pascal Lenormand, Clémence Dudeffant, Christian Czech, Fiona Grueninger, Charles Duyckaerts, Benoît Delatour, Marc Dhenain, Pierre Lafaye, Sylvie Bay
Today, molecular imaging of neurodegenerative diseases is mainly based on small molecule probes. Alternatively, antibodies are versatile tools that may be developed as new imaging agents. Indeed, they can be readily obtained to specifically target any antigen of interest and their scaffold can be functionalized. One of the critical issues involved in translating antibody-based probes to the clinic is the design and synthesis of perfectly-defined conjugates. Camelid single-domain antibody-fragments (VHHs) are very small and stable antibodies that are able to diffuse in tissues and potentially cross the blood brain barrier (BBB)...
August 2017: MAbs
https://www.readbyqxmd.com/read/28653860/gadolinium-deposition-in-human-brain-tissues-after-contrast-enhanced-mr-imaging-in-adult-patients-without-intracranial-abnormalities
#17
Robert J McDonald, Jennifer S McDonald, David F Kallmes, Mark E Jentoft, Michael A Paolini, David L Murray, Eric E Williamson, Laurence J Eckel
Purpose To determine whether gadolinium deposits in neural tissues of patients with intracranial abnormalities following intravenous gadolinium-based contrast agent (GBCA) exposure might be related to blood-brain barrier integrity by studying adult patients with normal brain pathologic characteristics. Materials and Methods After obtaining antemortem consent and institutional review board approval, the authors compared postmortem neuronal tissue samples from five patients who had undergone four to 18 gadolinium-enhanced magnetic resonance (MR) examinations between 2005 and 2014 (contrast group) with samples from 10 gadolinium-naive patients who had undergone at least one MR examination during their lifetime (control group)...
June 27, 2017: Radiology
https://www.readbyqxmd.com/read/28653648/gadolinium-deposition-in-the-brain-summary-of-evidence-and-recommendations
#18
REVIEW
Vikas Gulani, Fernando Calamante, Frank G Shellock, Emanuel Kanal, Scott B Reeder
Emerging evidence has linked MRI signal changes in deep nuclei of the brain with repeated administration of gadolinium-based contrast agents. Gadolinium deposits have been confirmed in brain tissue, most notably in the dentate nuclei and globus pallidus. Although some linear contrast agents appear to cause greater MRI signal changes than some macrocyclic agents, deposition of gadolinium has also been observed with macrocyclic agents. However, the extent of gadolinium deposition varies between agents. Furthermore, the clinical significance of the retained gadolinium in the brain, if any, remains unknown...
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28653641/gadolinium-deposition-practical-guidelines-in-the-face-of-uncertainty
#19
Kevin H Terashima, Daniel S Reich
No abstract text is available yet for this article.
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28642994/cardiovascular-magnetic-resonance-imaging-to-assess-myocardial-fibrosis-in-valvular-heart-disease
#20
Tomaz Podlesnikar, Victoria Delgado, Jeroen J Bax
The left ventricular (LV) remodeling process associated with significant valvular heart disease (VHD) is characterized by an increase of myocardial interstitial space with deposition of collagen and loss of myofibers. These changes occur before LV systolic function deteriorates or the patient develops symptoms. Cardiovascular magnetic resonance (CMR) permits assessment of reactive fibrosis, with the use of T1 mapping techniques, and replacement fibrosis, with the use of late gadolinium contrast enhancement...
June 22, 2017: International Journal of Cardiovascular Imaging
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