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Gadolinium deposition

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https://www.readbyqxmd.com/read/29773187/gd-accumulation-in-tissues-of-healthy-mice-upon-repeated-administrations-of-gadodiamide-and-gadoteridol
#1
Enza Di Gregorio, Rebecca Iani, Giuseppe Ferrauto, Raffaele Nuzzi, Silvio Aime, Eliana Gianolio
The aim of this work was to investigate, by five different administration protocols, the impact of the dosage, the time passed after the last injection and the frequency of injections, on accumulation and distribution of Gd-containing species in the body tissues of healthy mice upon repeated injections of Gadolinium Based Contrast Agents (GBCAs). Gadodiamide and Gadoteridol have been compared. The amount of Gd retained in several tissues/organs (cerebrum, cerebellum, spleen, liver, kidneys, eyes, skin, bone and muscle) has been assessed by ICP-MS upon administration of the GBCAs i) at three weeks or three months after the last administration, ii) when one, three or twelve doses of GBCA were administered and iii) when administrations were made every two weeks...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29748901/gadolinium-based-contrast-agents-induce-gadolinium-deposits-in-cerebral-vessel-walls-while-the-neuropil-is-not-affected-an-autopsy-study
#2
Stefanie Fingerhut, Michael Sperling, Markus Holling, Thomas Niederstadt, Thomas Allkemper, Alexander Radbruch, Walter Heindel, Werner Paulus, Astrid Jeibmann, Uwe Karst
Recent studies showed gadolinium depositions following serial administrations of gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging examinations in various parts of the brain with the dentate nucleus (DN) being most affected. Even though no clinical correlates of the deposits are known yet, an intensive debate developed if this might be harmful. The aim of the current study was to specify the gadolinium distribution in brain tissue of patients who received serial injections of GBCAs in the low-µm range and to explore any potential pathological tissue changes caused by gadolinium deposits...
May 10, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29744642/gadolinium-deposition-within-the-paediatric-brain-no-increased-intrinsic-t1-weighted-signal-intensity-within-the-dentate-nucleus-following-the-administration-of-a-minimum-of-four-doses-of-the-macrocyclic-agent-gadobutrol
#3
Jonathan R Young, Joe Qiao, Iren Orosz, Noriko Salamon, Mark A Franke, Hyun J Kim, Whitney B Pope
OBJECTIVES: To determine whether repeated administration of the macrocyclic gadolinium-based contrast agent (GBCA) gadobutrol in children is associated with T1-weighted hyperintensity within the dentate nucleus, an imaging surrogate for gadolinium deposition. METHODS: With institutional review board approval, we identified a cohort of eight patients aged 18 years or younger who underwent at least four gadobutrol-enhanced magnetic resonance imaging (MRI) examinations of the brain from 2013 to 2017...
May 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29727401/signal-changes-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-magnetic-resonance-images-after-intrathecal-administration-of-macrocyclic-gadolinium-contrast-agent
#4
Kerem Ozturk, Omer Fatih Nas, Esra Soylu, Bahattin Hakyemez
OBJECTIVES: The aim of this study was to evaluate signal changes in the dentate nucleus and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images (T1 WI) in a cohort of patients who have received intrathecal macrocyclic ionic gadolinium-based contrast agent (GBCA) gadoterate meglumine. MATERIALS AND METHODS: A group of 20 patients (male/female ratio, 8:12; mean age, 39.5 ± 15.5 years) who had not received intravenous GBCA but had received an intrathecal macrocyclic ionic GBCA (plus baseline and an additional final magnetic resonance imaging [MRI] for reference) from 2012 to 2017 were retrospectively included in this institutional review board-approved study...
April 30, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29725913/is-mri-imaging-in-pediatric-age-totally-safe-a-critical-reprisal
#5
REVIEW
Sergio Salerno, Claudio Granata, Marco Trapenese, Vittorio Cannata, Davide Curione, Maria Camilla Rossi Espagnet, Andrea Magistrelli, Paolo Tomà
Current radiological literature is strongly focussed on radiation imaging risks. Indeed, given there is a small but actual augment in cancer risk from exposure to ionizing radiation in children, it is important to understand what the risk of alternative techniques could be. We retrospectively review literature data concerning possible MR imaging risks, focussing on the biological effects of MR, sedation and gadolinium compound risks when dealing with infant patients. The main concerns can be summarized in: (1) Biological effects of non-ionizing electromagnetic fields (EMF) employed-whose mechanisms of interaction with human tissues are polarization, induced current, and thermal heating, respectively...
May 3, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29688408/spatiotemporal-distribution-of-fibrinogen-in-marmoset-and-human-inflammatory-demyelination
#6
Nathanael J Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Nicholas J Luciano, Jennifer A Lefeuvre, Matthew K Schindler, Emily C Leibovitch, Jae Kyu Ryu, Mark A Petersen, Afonso C Silva, Steven Jacobson, Katerina Akassoglou, Daniel S Reich
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. Although it has been extensively studied, the proximate trigger of the immune response remains uncertain. Experimental autoimmune encephalomyelitis in the common marmoset recapitulates many radiological and pathological features of focal multiple sclerosis lesions in the cerebral white matter, unlike traditional experimental autoimmune encephalomyelitis in rodents. This provides an opportunity to investigate how lesions form as well as the relative timing of factors involved in lesion pathogenesis, especially during early stages of the disease...
April 20, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29563507/in-situ-measurements-of-rare-earth-elements-in-deep-sea-sediments-using-nuclear-methods
#7
Jasmina Obhođaš, Davorin Sudac, Ilker Meric, Helge E S Pettersen, Milivoj Uroić, Karlo Nađ, Vlado Valković
The prospecting activities for finding new rare earth elements (REE) sources have increased greatly in recent years. One of the main discoveries was announced in 2011 by Japanese researchers who found large quantities of REE on the ocean seafloor at the sea depths greater than 4,000 m. The classic approach to investigate REE in deep sea sediments is to obtain sediment samples by drilling that is followed by laborious laboratory analysis. This is very expensive, time consuming and not appropriate for exploring vast areas...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535330/evaluating-the-potential-of-chelation-therapy-to-prevent-and-treat-gadolinium-deposition-from-mri-contrast-agents
#8
Julian A Rees, Gauthier J-P Deblonde, Dahlia D An, Camille Ansoborlo, Stacey S Gauny, Rebecca J Abergel
Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents (GBCAs) for MRI, prompting the European Medicines Agency to recommend discontinuing the use of over half of the GBCAs currently approved for clinical applications. To address this problem, we find that the orally-available metal decorporation agent 3,4,3-LI(1,2-HOPO) demonstrates superior efficacy at chelating and removing Gd from the body compared to diethylenetriaminepentaacetic acid, a ligand commonly used in the United States in the GBCA Gadopentetate (Magnevist)...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535138/biomarkers-of-myocardial-fibrosis-revealing-the-natural-history-of-fibrogenesis-in-fabry-disease-cardiomyopathy
#9
Patrício Aguiar, Olga Azevedo, Rui Pinto, Jacira Marino, Carlos Cardoso, Nuno Sousa, Damião Cunha, Derralynn Hughes, José Luís Ducla Soares
BACKGROUND: Cardiomyopathy is a major determinant of overall Fabry disease (FD) prognosis, with the worst outcomes in patients with myocardial fibrosis. Late gadolinium enhancement is currently the gold standard for evaluation of replacement myocardial fibrosis; however, this event is irreversible, thus identification of biomarkers of earlier diffuse fibrosis is paramount. METHODS AND RESULTS: Type I collagen synthesis and degradation biomarkers (PICP [carboxyterminal propeptide of procollagen type I], ICTP [carboxyterminal telopeptide of type I collagen], and MMP1 [matrix metalloproteinase 1] and MMP2) and markers of bone synthesis and degradation were evaluated (to adjust type I collagen metabolism to bone turnover) in FD patients and controls...
March 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29530452/the-impact-of-gadolinium-deposition-on-radiology-practice-an-international-survey-of-radiologists
#10
Ryan T Fitzgerald, Vikas Agarwal, Jenny K Hoang, Frank Gaillard, Andrew Dixon, Emanuel Kanal
RATIONALE AND OBJECTIVES: Brain deposition of gadolinium following the administration of gadolinium-based contrast agents (GBCAs) was initially reported in 2014. Gadolinium deposition is now recognized as a dose-dependent consequence of exposure. The potential clinical implications are not yet understood. The purpose of this study was to determine radiologists' reporting practices in response to gadolinium deposition. MATERIALS AND METHODS: An electronic survey querying radiologists' practices regarding gadolinium deposition was distributed by Radiopaedia...
February 7, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29523896/a-review-of-the-current-evidence-on-gadolinium-deposition-in-the-brain
#11
REVIEW
Richard Pullicino, Mark Radon, Shubhabrata Biswas, Maneesh Bhojak, Kumar Das
Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies...
March 9, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29508245/gadolinium-based-contrast-agent-related-toxicities
#12
REVIEW
Luca Pasquini, Antonio Napolitano, Emiliano Visconti, Daniela Longo, Andrea Romano, Paolo Tomà, Maria Camilla Rossi Espagnet
In recent years, gadolinium-based contrast agents have been associated with different types of toxicity. In particular, nephrogenic systemic fibrosis, a progressive sclerotic-myxedematous systemic disease of unknown etiology, is related to gadolinium-based contrast agent administration in patients with kidney dysfunction. More recently, evidence of magnetic resonance signal intensity changes on pre-contrast T1-weighted images after multiple gadolinium-based contrast agent administrations resulted in the hypothesis of gadolinium brain accumulation in patients with normal renal function, subsequently confirmed in pathological samples...
March 2018: CNS Drugs
https://www.readbyqxmd.com/read/29504171/evaluation-of-noncontrast-mr-enterography-for-pediatric-inflammatory-bowel-disease-assessment
#13
Michael Hunter Lanier, Anup S Shetty, Amber Salter, Geetika Khanna
BACKGROUND: Gadolinium deposition in normal tissues is being increasingly recognized. Children with inflammatory bowel disease (IBD) undergo frequent imaging with contrast-enhanced MR enterography (MRE). PURPOSE: To determine the impact of intravenous (IV) gadolinium in assessment of pediatric IBD by MRE. STUDY TYPE: Retrospective, case series. POPULATION: Radiology information system was searched to identify all children who underwent MRE and endoscopy within 30 days in 2016...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29465099/is-it-safe-to-use-gadolinium-based-contrast-agents-in-mri
#14
R Pullicino, K Das
Gadolinium-based contrast agents have greatly expanded the capability of magnetic resonance imaging and have been used extensively in neuroradiology over the past 30 years. When initially developed they were thought to be relatively harmless; it was later discovered they are associated with nephrogenic systemic fibrosis and should be used with caution in certain patient groups, especially those with renal failure. Lately it has been found that the use of these contrast agents may result in deposition of gadolinium in the brain even in patients with an intact blood-brain barrier...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29462023/advocating-the-development-of-next-generation-high-relaxivity-gadolinium-chelates-for-clinical-magnetic-resonance
#15
Val M Runge, Johannes T Heverhagen
The question of improved relaxivity, and potential efficacy therein, for a next-generation of magnetic resonance gadolinium chelates with extracellular distribution and renal excretion, which could also be viewed from the perspective of dose, is addressed on the basis of historical development, animal experimentation, and human trials. There was no systematic evaluation that preceded the choice of 0.1 mmol/kg as the standard dose for human imaging with the gadolinium chelates. In part, this dose was chosen owing to bloodwork abnormalities seen in phase I and phase II studies...
February 17, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29437269/deep-learning-enables-reduced-gadolinium-dose-for-contrast-enhanced-brain-mri
#16
Enhao Gong, John M Pauly, Max Wintermark, Greg Zaharchuk
BACKGROUND: There are concerns over gadolinium deposition from gadolinium-based contrast agents (GBCA) administration. PURPOSE: To reduce gadolinium dose in contrast-enhanced brain MRI using a deep learning method. STUDY TYPE: Retrospective, crossover. POPULATION: Sixty patients receiving clinically indicated contrast-enhanced brain MRI. SEQUENCE: 3D T1 -weighted inversion-recovery prepped fast-spoiled-gradient-echo (IR-FSPGR) imaging was acquired at both 1...
February 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29431424/gadolinium-free-contrast-agents-for-magnetic-resonance-imaging-of-the-central-nervous-system
#17
Eric M Gale, Peter Caravan
We discuss how the recent revelation that gadolinium (Gd) from commercially available MRI contrast agents is irreversibly and cumulatively deposited in the central nervous system is driving innovation toward Gd-free contrast agents for neuroradiology.
March 21, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29429967/primary-central-nervous-system-vasculitis-associated-with-lymphoma
#18
Carlo Salvarani, Robert D Brown, Teresa J H Christianson, John Huston, Stephen M Ansell, Caterina Giannini, Gene G Hunder
OBJECTIVES: To record the clinical findings, response to therapy, and course of patients with primary CNS vasculitis (PCNSV) associated with lymphoma. PATIENTS AND METHODS: We reviewed the histories of 936 patients with a diagnosis of any type of vasculitis and lymphoma who were seen at the Mayo Clinic over a 32-year period. Ten patients with both PCNSV and lymphoma were identified. We compared the findings in these 10 patients with those from 158 patients with PCNSV without lymphoma seen over 29 years...
March 6, 2018: Neurology
https://www.readbyqxmd.com/read/29419708/intravenous-calcium-zinc-diethylene-triamine-penta-acetic-acid-in-patients-with-presumed-gadolinium-deposition-disease-a-preliminary-report-on-25-patients
#19
Richard C Semelka, Miguel Ramalho, Michael Jay, Lisa Hickey, Joseph Hickey
OBJECTIVES: The aim of this study was to report the use of intravenous calcium (Ca)-/zinc (Zn)-diethylene triamine penta-acetic acid (DTPA) for the treatment of 25 symptomatic patients diagnosed with gadolinium deposition disease (GDD). MATERIALS AND METHODS: Written informed consent was obtained. Twenty-five patients (18 women; mean age, 46.8 ± 15.3 years) with a diagnosis of GDD were included. All patients had received at least 1 administration of a gadolinium (Gd)-based contrast agent...
June 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29419400/high-signal-intensity-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-mr-images-comparison-between-gadobutrol-and-linear-gadolinium-based-contrast-agents
#20
F G Moser, C T Watterson, S Weiss, M Austin, J Mirocha, R Prasad, J Wang
BACKGROUND AND PURPOSE: In view of the recent observations that gadolinium deposits in brain tissue after intravenous injection, our aim of this study was to compare signal changes in the globus pallidus and dentate nucleus on unenhanced T1-weighted MR images in patients receiving serial doses of gadobutrol, a macrocyclic gadolinium-based contrast agent, with those seen in patients receiving linear gadolinium-based contrast agents. MATERIALS AND METHODS: This was a retrospective analysis of on-site patients with brain tumors...
February 1, 2018: AJNR. American Journal of Neuroradiology
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