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Gadolinium deposition

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https://www.readbyqxmd.com/read/29355511/low-dose-d-amphetamine-induced-regression-of-liver-fat-deposits-in-dercum-disease
#1
S Ghazala, J Bilal, E Ross, B Kalb, I B Riaz, K L Herbst
BACKGROUND/AIM: Dercum disease is a rare disorder of painful subcutaneous adipose tissue masses typically presenting as a constellation of signs and symptoms affecting most organs including slow lymphatic flow and fatty liver. METHOD: The University of Arizona Institutional Review Board considered this report exempt after patient consent. Multislice, multisequence magnetic resonance imaging (MRI) of the abdomen and pelvis was performed before and after d-amphetamine, with and without intravenous gadolinium...
January 17, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29319556/gadolinium-accumulation-in-the-deep-cerebellar-nuclei-and-globus-pallidus-after-exposure-to-linear-but-not-macrocyclic-gadolinium-based-contrast-agents-in-a-retrospective-pig-study-with-high-similarity-to-clinical-conditions
#2
Janina Boyken, Thomas Frenzel, Jessica Lohrke, Gregor Jost, Hubertus Pietsch
OBJECTIVE: The aim of this retrospective study was to determine the gadolinium (Gd) concentration in different brain areas in a pig cohort that received repeated administration of Gd-based contrast agents (GBCAs) at standard doses over several years, comparable with a clinical setting. MATERIAL AND METHODS: Brain tissue was collected from 13 Göttingen mini pigs that had received repeated intravenous injections of gadopentetate dimeglumine (Gd-DTPA; Magnevist) and/or gadobutrol (Gadovist)...
January 9, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29300210/pediatric-brain-gadolinium-deposition-in-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-images-is-dependent-on-the-type-of-contrast-agent
#3
Young Jin Ryu, Young Hun Choi, Jung-Eun Cheon, Woo-Jin Lee, Subin Park, Ji Eun Park, Woo Sun Kim, In-One Kim
PURPOSE: The aim of this study was to identify the signal intensity (SI) changes in the dentate nucleus (DN) and the globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images after multiple administration of gadolinium-based contrast agents (GBCAs) in children and compare those changes between linear and macrocyclic GBCAs. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and the requirement for informed consent was waived...
January 2, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29278694/non-clinical-assessment-of-safety-and-gadolinium-deposition-after-cumulative-administration-of-gadobenate-dimeglumine-multihance%C3%A2-to-neonatal-and-juvenile-rats
#4
Simona Bussi, Laure Penard, Roberta Bonafè, Catherine Botteron, Roberto Celeste, Alessandra Coppo, Roberta Queliti, Miles A Kirchin, Fabio Tedoldi, Federico Maisano
To determine the impact of single and cumulative doses of MultiHance on toxicity, pharmacokinetics, tissue gadolinium presence, behavior and neurological function in juvenile rats. Juvenile male and female rats received either physiological saline or MultiHance at 0.6, 1.25 or 2.5 mmol/kg bodyweight. Animals received either single or six consecutive MultiHance administrations and were sacrificed the day after the last administration or after a 60-day treatment-free period. Animals were assessed for behavior, cognitive function, grip strength, gait, pupillary reflex, and auditory reflex, as well as for physical development, sexual maturation and histopathology...
December 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29277593/oculoleptomeningeal-amyloidosis-secondary-to-the-rare-transthyretin-c-381t-g-p-ile127met-mutation
#5
Francois Mathieu, Erin Morgan, Joyce So, David G Munoz, Warren Mason, Paul Kongkham
BACKGROUND: Oculoleptomeningeal amyloidosis (OLMA) represents a rare subtype of familial transthyretin (TTR) amyloidosis, characterized by deposition of amyloid in cranial and spinal leptomeninges along with ocular involvement. Of more than 100 TTR mutations identified, few have been associated with OLMA. Herein we describe the first report of leptomeningeal amyloidosis associated with the c.381T>G (p.Ile127Met) TTR mutation, linking this variant in the OLMA phenotype. CASE DESCRIPTION: A 53 year-old male presented with a 2-year history of progressive symptoms including upper and lower limb weakness, ataxia, peripheral and autonomic neuropathy...
December 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29237148/observed-deposition-of-gadolinium-in-bone-using-a-new-noninvasive-in-vivo-biomedical-device-results-of-a-small-pilot-feasibility-study
#6
Michelle L Lord, David R Chettle, James L Gräfe, Michael D Noseworthy, Fiona E McNeill
Purpose To perform a preliminary evaluation of a noninvasive measurement system to assess gadolinium deposition in bone and to investigate the relationship between the administration of gadolinium-based contrast agents (GBCAs) and gadolinium retention in bone. Materials and Methods In vivo measurement of gadolinium retention in tibia bones was performed in 11 exposed subjects who previously received GBCAs (six exposed subjects were from a study performed 5 years previously involving injection of GBCAs in healthy volunteers; five exposed subjects had self-reported GBCA exposure), and 11 sex- and age-matched control subjects without a history of GBCA exposure...
December 13, 2017: Radiology
https://www.readbyqxmd.com/read/29208312/gadolinium-deposition-in-the-paediatric-brain-t1-weighted-hyperintensity-within-the-dentate-nucleus-following-repeated-gadolinium-based-contrast-agent-administration
#7
J R Young, I Orosz, M A Franke, H J Kim, D Woodworth, B M Ellingson, N Salamon, W B Pope
AIM: To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted signal intensity within the cerebellar dentate nucleus. MATERIALS AND METHODS: With institutional review board approval for this The Health Insurance Portability and Accountability Act-compliant retrospective study, a cohort of 41 patients under the age of 18 years who underwent at least four contrast-enhanced magnetic resonance imaging (MR) examinations of the brain from 2005 to 2015 were identified...
December 2, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29196974/the-effects-of-gadolinium-based-contrast-agents-on-the-cerebellum-from-basic-research-to-neurological-practice-and-from-pregnancy-to-adulthood
#8
EDITORIAL
Winda Ariyani, Miski Aghnia Khairinisa, Gaetano Perrotta, Mario Manto, Noriyuki Koibuchi
Gadolinium (Gd)-based contrast agents (GBCAs) are used in magnetic resonance imaging (MRI) to increase the diagnostic yield. Current reports using animal models or human subjects have shown that GBCAs may be deposited in brain including the cerebellum. Although further studies may be required to clarify the toxicity of GBCAs, we should be more cautious to use these agents particularly in patients who more likely to have repeated enhanced MRI along their lifespan. In this editorial, current studies to clarify the toxicity of GBCAs in the cerebellum are introduced...
December 1, 2017: Cerebellum
https://www.readbyqxmd.com/read/29189641/mri-characteristics-of-spinal-ependymoma-in-who-grade-ii-a-review-of-59-cases
#9
Kazuyoshi Kobayashi, Shiro Imagama, Fumihiko Kato, Tokumi Kanemura, Koji Sato, Mitsuhiro Kamiya, Kei Ando, Kenyu Ito, Mikito Tsushima, Akiyuki Matsumoto, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Yoshihiro Nishida, Naoki Ishiguro
STUDY DESIGN: Retrospective multicenter study. OBJECTIVE: The goal of this study is to determine the characteristic imaging features of spinal ependymoma in a review of MRI data for a large series of surgically proven cases. SUMMARY OF BACKGROUND DATA: Common spinal intramedullary neoplasms are mostly ependymomas and comprise 50-60% of spinal neuroepithelial tumors in adults. Preoperative prediction of the pathological diagnosis could enhance surgical planning and explanation of the procedure to patients...
November 20, 2017: Spine
https://www.readbyqxmd.com/read/29173468/spatially-resolved-quantification-of-gadolinium-deposited-in-the-brain-of-a-patient-treated-with-gadolinium-based-contrast-agents
#10
Stefanie Fingerhut, Ann-Christin Niehoff, Michael Sperling, Astrid Jeibmann, Werner Paulus, Thomas Niederstadt, Thomas Allkemper, Walter Heindel, Markus Holling, Uwe Karst
Due to its paramagnetic properties resulting from seven unpaired f-electrons, Gd is frequently applied in magnetic resonance imaging examinations. Due to the acute toxicity of free Gd3+, ligand ions based on polyaminocarboxylic acids are used to create thermodynamically stable linear or macrocyclic complexes. The highly water soluble Gd-based contrast agents (GBCAs) are known to be excreted fast and unmetabolized, mostly via the kidneys. Nevertheless, recent studies showed that Gd traces persists not only in animal but also in human brain...
January 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29155619/gadolinium-retention-and-deposition-revisited-how-the-chemical-properties-of-gadolinium-based-contrast-agents-and-the-use-of-animal-models-inform-us-about-the-behavior-of-these-agents-in-the-human-brain
#11
https://www.readbyqxmd.com/read/29142812/left-ventricle-relative-apical-sparing-in-cardiac-amyloidosis
#12
Marianna Nardozza, Elisabetta Chiodi, Donato Mele
Amyloidosis is a disease characterized by the extracellular deposition of the protein amyloid. It is a multiorgan disease, and cardiac involvement is not uncommon, generally in the form of a restrictive cardiomyopathy. Typical aspects of cardiac amyloidosis have been described at echocardiography and magnetic resonance imaging (MRI). In particular, the relative apical sparing at two-dimensional speckle-tracking echocardiography has been reported to be specific for cardiac amyloidosis. In our case, we report for the first time that this echocardiographic sign is related to lack of hyperenhancement at late gadolinium enhancement imaging in cardiac MRI...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29134367/imaging-of-cardiovascular-disease-in-pregnancy-and-the-peripartum-period
#13
REVIEW
Theodore Pierce, Meline Hovnanian, Sandeep Hedgire, Brian Ghoshhajra
Cardiovascular disease is an important cause of morbidity and mortality during pregnancy and the postpartum period. During pregnancy, the cardiovascular system undergoes extensive hemodynamic, hormonal, and microstructural changes which may exacerbate a preexisting underlying cardiovascular condition or predispose to cardiovascular complications not typically seen in young healthy women. Such conditions include spontaneous coronary artery dissection, atherosclerotic coronary artery disease, and peripartum cardiomyopathy...
November 14, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29110904/retention-of-gadolinium-compounds-used-in-magnetic-resonance-imaging-a-critical-review-and-the-recommendations-of-regulatory-agencies
#14
L Martí-Bonmatí, E Martí-Bonmatí
The Spanish Agency for Drugs and Healthcare Products (AEMPS), based on the recommendations of the European Committee for Risk Assessment in Pharmacovigilance, established on 13 March 2017 that linear gadolinium-based MR contrast media, such as MultiHance, Omniscan, Magnevist (currently not marketed) and Optimark (no longer marketed in Spain), the clinical benefits do not outweigh the potential risks derived from their use. AEMPS recommends to suspend its marketing for general use based on the retention of these compounds in the brain...
November 2017: Radiología
https://www.readbyqxmd.com/read/29052696/gadolinium-deposition-in-the-pediatric-brain-reply
#15
Jennifer S McDonald, Robert J McDonald, Laurence J Eckel
No abstract text is available yet for this article.
October 9, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29052686/gadolinium-deposition-in-the-pediatric-brain
#16
Donna R Roberts, Cynthia A Welsh, W Clay Davis
No abstract text is available yet for this article.
December 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29047804/effect-of-oxygen-partial-pressure-in-deposition-ambient-on-the-properties-of-rf-magnetron-sputter-deposited-gd2o3-thin-films
#17
S Maidul Haque, Rajnarayan De, S Tripathi, C Mukherjee, A K Yadav, Dibyendu Bhattacharyya, S N Jha, N K Sahoo
Gadolinium oxide is an excellent optical material that offers high transmission in a wide wavelength range of 200-1600 nm and exhibits a high bulk refractive index of ∼1.80 at 550 nm. In the present study, a set of Gd2O3 thin films has been deposited on fused silica substrates by RF sputtering of a Gd2O3 target under various O2 to Ar flow ratios. The samples have been characterized by grazing incidence x-ray diffraction (GIXRD) to study the long range structural behavior, by GIXR to study density and surface roughness of the films, by atomic force microscopy measurements to study morphological properties, by Rutherford backscattering measurements for compositional studies, and by transmission spectrophotometry and spectroscopic ellipsometry techniques to study their optical properties...
August 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29038383/biological-effects-of-mri-contrast-agents-gadolinium-retention-potential-mechanisms-and-a-role-for-phosphorus
#18
REVIEW
Joel Garcia, Stephen Z Liu, Angelique Y Louie
No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room-which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens...
November 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28990973/the-issue-of-gadolinium-retained-in-tissues-insights-on-the-role-of-metal-complex-stability-by-comparing-metal-uptake-in-murine-tissues-upon-the-concomitant-administration-of-lanthanum-and-gadolinium-diethylentriamminopentaacetate
#19
Enza Di Gregorio, Giuseppe Ferrauto, Chiara Furlan, Stefania Lanzardo, Raffaele Nuzzi, Eliana Gianolio, Silvio Aime
OBJECTIVES: The aim of the study was to explore the role of the stability of metal complexes in the processes that lead to the metal retention in the brain and other tissues of mice administered with lanthanides-based contrast agents. This issue was tackled by the simultaneous injection of gadolinium (Gd)-diethylentriamminopentaacetate (DTPA) and lanthanum-DTPA, which have the same charge and structure but differ in their thermodynamic stability by 3 orders of magnitude. MATERIALS AND METHODS: A total of 20 healthy BALB/c mice were administered by a single intravenous injection with a dose consisting of 0...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28964467/safety-of-contrast-material-use-in-children
#20
REVIEW
Bruno P Soares, Maarten H Lequin, Thierry A G M Huisman
Iodinated and gadolinium-based contrast materials have excellent safety profiles for use in pediatric computed tomography and MR imaging. The rate of acute adverse reactions and contrast-induced nephropathy is lower than in adults. The relationship between nephrogenic systemic fibrosis and gadolinium administration is well established and only a small number of children suffer from this debilitating disorder. The recent finding of gadolinium deposition in the brain of patients with normal renal function has renewed concerns regarding its long-term toxicity...
November 2017: Magnetic Resonance Imaging Clinics of North America
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