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Gadolinium deposition

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https://www.readbyqxmd.com/read/28323657/histology-and-gadolinium-distribution-in-the-rodent-brain-after-the-administration-of-cumulative-high-doses-of-linear-and-macrocyclic-gadolinium-based-contrast-agents
#1
Jessica Lohrke, Anna-Lena Frisk, Thomas Frenzel, Laura Schöckel, Martin Rosenbruch, Gregor Jost, Diana Constanze Lenhard, Martin A Sieber, Volker Nischwitz, Astrid Küppers, Hubertus Pietsch
OBJECTIVES: Retrospective studies in patients with primary brain tumors or other central nervous system pathologies as well as postmortem studies have suggested that gadolinium (Gd) deposition occurs in the dentate nucleus (DN) and globus pallidus (GP) after multiple administrations of primarily linear Gd-based contrast agents (GBCAs). However, this deposition has not been associated with any adverse effects or histopathological alterations. The aim of this preclinical study was to systematically examine differences between linear and macrocyclic GBCAs in their potential to induce changes in brain and skin histology including Gd distribution in high spatial resolution...
March 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28298504/intracranial-deposition-of-intravenous-gadolinium-contrast-a-literature-review
#2
Jennifer Franco
No abstract text is available yet for this article.
March 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28283728/survey-of-gadolinium-based-contrast-agent-utilization-among-the-members-of-the-society-for-pediatric-radiology-a-quality-and-safety-committee-report
#3
Einat Blumfield, Michael M Moore, Mary K Drake, Thomas R Goodman, Kristopher N Lewis, Laura T Meyer, Thang D Ngo, Christina Sammet, Arta Luana Stanescu, David W Swenson, Thomas L Slovis, Ramesh S Iyer
BACKGROUND: Gadolinium-based contrast agents (GBCAs) have been used for magnetic resonance (MR) imaging over the last three decades. Recent reports demonstrated gadolinium retention in patients' brains following intravenous administration. Since gadolinium is a highly toxic heavy metal, there is a potential for adverse effects from prolonged retention or deposition, particularly in children. For this reason, the Society (SPR) for Pediatric Radiology Quality and Safety committee conducted a survey to evaluate the current status of GBCAs usage among pediatric radiologists...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28283727/use-of-gadolinium-based-magnetic-resonance-imaging-contrast-agents-and-awareness-of-brain-gadolinium-deposition-among-pediatric-providers-in-north-america
#4
Leena B Mithal, Payal S Patel, Divakar Mithal, Hannah L Palac, Michael N Rozenfeld
BACKGROUND: Numerous recent articles have reported brain gadolinium deposition when using linear but not macrocyclic gadolinium-based contrast agents (GBCAs). OBJECTIVE: To determine the current landscape of gadolinium use among pediatric institutions and the knowledge base of radiologists and referring providers with regard to GBCAs and brain gadolinium deposition. MATERIALS AND METHODS: We e-mailed voluntary closed surveys to 5,390 physicians in various pediatric professional societies between January 2016 and March 2016...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28202695/distribution-map-of-gadolinium-deposition-within-the-cerebellum-following-gbca-administration
#5
Donna R Roberts, Cynthia A Welsh, David P LeBel, W Clay Davis
No abstract text is available yet for this article.
March 21, 2017: Neurology
https://www.readbyqxmd.com/read/28193901/exceedingly-small-iron-oxide-nanoparticles-as-positive-mri-contrast-agents
#6
He Wei, Oliver T Bruns, Michael G Kaul, Eric C Hansen, Mariya Barch, Agata Wiśniowska, Ou Chen, Yue Chen, Nan Li, Satoshi Okada, Jose M Cordero, Markus Heine, Christian T Farrar, Daniel M Montana, Gerhard Adam, Harald Ittrich, Alan Jasanoff, Peter Nielsen, Moungi G Bawendi
Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBCAs) are the mainstream MRI contrast agents used in the clinic. GBCAs have shown efficacy and are safe to use with most patients; however, some GBCAs have a small risk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recently linked to gadolinium (Gd) exposure during MRI with contrast...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28187173/the-presence-of-the-gadolinium-based-contrast-agent-depositions-in-the-brain-and-symptoms-of-gadolinium-neurotoxicity-a-systematic-review
#7
Cyprian Olchowy, Kamil Cebulski, Mateusz Łasecki, Radosław Chaber, Anna Olchowy, Krzysztof Kałwak, Urszula Zaleska-Dorobisz
BACKGROUND AND PURPOSE: Gadolinium based contrast agents (GBCAs) are widely used in magnetic resonance imaging, but recently, high signal intensity in the cerebellum structures was reported after repeated administrations of contrast- enhanced magnetic resonance images. The aim of this systematic review was to investigate the association between increased signal intensity in the dentate nucleus and globus pallidus in the brain and repeated administrations of GBCAs. Additionally, we focused on possible short- and long-term consequences of gadolinium use in those patients...
2017: PloS One
https://www.readbyqxmd.com/read/28135639/modulation-of-osteoblast-behavior-on-nanopatterned-yttria-stabilized-zirconia-surfaces
#8
Ginny Soon, Belinda Pingguan-Murphy, Sheikh Ali Akbar
This study utilizes the technique of self-assembly to fabricate arrays of nanoislands on (001)-oriented yttria-stabilized zirconia single crystal substrates with miscut of 10° toward <110> direction. These self-assembled nanostructures were annealed at 1100°C for 5h upon doping with 10mol% gadolinium-doped ceria (GDC) by powder-suspension based method. X-Ray diffraction result showed that the miscut substrate after doping GDC was in the cubic phase. Energy dispersive X-ray (EDX) illustrates that the nanopatterned material contains all the elements from the GDC source and yttria-stabilized zirconia (YSZ) substrate...
January 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28129067/radiologic-pathologic-correlation-of-primary-and-secondary-cardiomyopathies-mr-imaging-and-histopathologic-findings-in-hearts-from-autopsy-and-transplantation
#9
Hiromi Hashimura, Fumiko Kimura, Hatsue Ishibashi-Ueda, Yoshiaki Morita, Masahiro Higashi, Shintaro Nakano, Atsushi Iguchi, Kensuke Uotani, Kazuro Sugimura, Hiroaki Naito
Cardiac magnetic resonance (MR) imaging with late gadolinium enhancement (LGE) is used to detect and assess the myocardial damage seen with a variety of cardiomyopathies. Gadolinium-based contrast material accumulates in the expanded interstitial space of the myocardium. Areas with LGE correspond to replacement fibrosis, fibrofatty change, epithelioid granuloma, inflammatory cell infiltration, cardiomyocyte necrosis, and amyloid deposition-conditions that represent a focal increase in interstitial space. Areas without LGE correspond to interstitial or plexiform fibrosis, mildly degenerated cardiomyocytes, inflammatory cell infiltration, and diffuse amyloid deposition-conditions that represent diffuse increases in interstitial space...
January 27, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28109895/pilot-study-of-the-mirabilis-system-prototype-for-rapid-noninvasive-uterine-fibroid-treatment-using-an-ultrasound-guided-volumetric-shell-ablation-technique
#10
Jessica E Parsons, Michael P H Lau, Patrick J Martin, Joel J Islas Lagos, Juan M Aguilar Aguirre, José G Garza Leal
STUDY OBJECTIVE: The primary objective of this pilot study was to evaluate the safety and acute tissue ablation efficacy of a transabdominal high-intensity focused ultrasound (HIFU) prototype device that uses ultrasound imaging guidance for rapid noninvasive ablation of uterine fibroids. The secondary objective was to assess preliminary fibroid-related symptom improvement and fibroid volume reduction at 3 - 6 months post-treatment in subsets of patients. DESIGN: Multi-center prospective single-arm pilot study (Canadian Task Force Classification II-2) SETTING: University-affiliated teaching hospital and private community hospital PATIENTS: Women with a diagnosis of symptomatic uterine fibroids planning to undergo hysterectomy INTERVENTIONS: Seventy-three (73) women underwent transabdominal ultrasound-guided HIFU treatment using a volumetric ablation technique referred to as 'shell ablation,' in which the HIFU energy is deposited in patterns that partially encapsulate the peripheral region of the targeted fibroid(s)...
January 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28089499/the-stability-of-gadolinium-based-contrast-agents-in-human-serum-a-reanalysis-of-literature-data-and-association-with-clinical-outcomes
#11
John P Prybylski, Richard C Semelka, Michael Jay
PURPOSE: To reanalyze literature data of gadolinium (Gd)-based contrast agents (GBCAs) in plasma with a kinetic model of dissociation to provide a comprehensive assessment of equilibrium conditions for linear GBCAs. METHODS: Data for the release of Gd from GBCAs in human serum was extracted from a previous report in the literature and fit to a kinetic dissociation/association model. The conditional stabilities (logKcond) and percent intact over time were calculated using the model rate constants...
May 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28026111/biomedical-applications-of-metal-encapsulated-fullerene-nanoparticles
#12
REVIEW
Tinghui Li, Harry C Dorn
The carbonaceous nanomaterials known as metallofullerenes have attracted considerable attention due to their attractive properties. The robust nature of the "Trojan Horse" fullerene cage provides an important structural component, which isolates the metal cluster from the bioenvironment. The large carbon surface area is ideally suited for multiple exo-functionalization approaches to modify the hydrophobic cage for a more hydrophilic bioenvironment. Additionally, peptides and other agents are readily covalently attached to this nanoprobe for targeting applications...
February 2017: Small
https://www.readbyqxmd.com/read/28003610/the-impact-of-gadolinium-based-contrast-agent-for-carbon-ion-radiotherapy
#13
Nao Mogi, Makoto Sakai, Ryosuke Okada, Yusuke Itabashi, Yasuhiro Fukushima, Yoshiki Kubota, Takayuki Sutou, Takashi Nakano, Tatsuya Ohno
PURPOSE: The contrast agent used in the diagnostic department has high atomic numbers and might influence dose deposition in the particle therapy. In particular, the influence of gadolinium-based (Gd) contrast agent on range in carbon ion radiotherapy has not yet been evaluated. For this reason, we avoid carbon treatment and planning computed tomography (CT) acquisition on days when the contrast-enhanced magnetic resonance image (MRI) is performed. In this study, we evaluated the time required for this beam range effect to vanish by evaluating the temporal changes in the CT values after an enhanced MRI as well as the stopping power of Gd solution...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27965733/calcium-oxalate-induces-renal-injury-through-calcium-sensing-receptor
#14
Xiaoran Li, Junhai Ma, Wei Shi, Yu Su, Xu Fu, Yanlin Yang, Jianzhong Lu, Zhongjin Yue
Objective. To investigate whether calcium-sensing receptor (CaSR) plays a role in calcium-oxalate-induced renal injury. Materials and Methods. HK-2 cells and rats were treated with calcium oxalate (CaOx) crystals with or without pretreatment with the CaSR-specific agonist gadolinium chloride (GdCl3) or the CaSR-specific antagonist NPS2390. Changes in oxidative stress (OS) in HK-2 cells and rat kidneys were assessed. In addition, CaSR, extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal protein kinase (JNK), and p38 expression was determined...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27911291/a-metal-free-method-for-producing-mri-contrast-at-amyloid-%C3%AE
#15
Silvia Hilt, Tang Tang, Jeffrey H Walton, Madhu Budamagunta, Izumi Maezawa, Tamás Kálai, Kálmán Hideg, Vikrant Singh, Heike Wulff, Qizhi Gong, Lee-Way Jin, Angelique Louie, John C Voss
Alzheimer's disease (AD) is characterized by depositions of the amyloid-β (Aβ) peptide in the brain. The disease process develops over decades, with substantial neurological loss occurring before a clinical diagnosis of dementia can be rendered. It is therefore imperative to develop methods that permit early detection and monitoring of disease progression. In addition, the multifactorial pathogenesis of AD has identified several potential avenues for AD intervention. Thus, evaluation of therapeutic candidates over lengthy trial periods also demands a practical, noninvasive method for measuring Aβ in the brain...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27885402/-retention-of-contrast-media-in-the-history-of-radiology-sequelae%C3%A2-of%C3%A2-the-former-use-of-thorotrast-and-new-challenges
#16
G van Kaick, S Delorme
Detection of gadolinium deposits in patients who have repeatedly been administered intravenous gadolinium chelates have given rise to concern regarding the long-term safety of magnetic resonance imaging (MRI) contrast media. Nevertheless, negative long-term clinical effects have not yet been observed. In some publications parallels have been drawn to the sequelae of thorotrast that was formerly used for arterial angiography. In this article the history of thorotrast use is briefly described and in particular why, despite warnings, this substance was used frequently and worldwide...
December 2016: Der Radiologe
https://www.readbyqxmd.com/read/27870629/hepatic-gadolinium-deposition-in-pediatric-hematopoietic-stem-cell-transplant-recipients
#17
Eric Lancelot, Jean-Sébastien Raynaud, Nicolas Ferrari, Pierre Desché
No abstract text is available yet for this article.
December 2016: Radiology
https://www.readbyqxmd.com/read/27834725/do-gadolinium-based-contrast-agents-affect-18-f-fdg-pet-ct-uptake-in-the-dentate-nucleus-and-the-globus-pallidus-a-pilot-study
#18
Kyle Bauer, Alaina Lathrum, Osama Raslan, Patrick V Kelly, Yihua Zhou, Debra Hewing, Crystal Botkin, James A Turner, Medhat Osman
Gadolinium is toxic and to avoid its deposition in tissues, it must be chemically bonded with nonmetal ions to facilitate its excretion by the kidneys. High signal intensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted MR images has been both morphologically and pathologically linked to gadolinium-based contrast agent (GBCA) retention in the brain. The purpose of this study was to determine whether repeated administrations of GBCA would affect the uptake of (18)F-FDG in the DN and GP on PET/CT...
March 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27797676/global-and-regional-brain-assessment-with-quantitative-mr-imaging-in-patients-with-prior-exposure-to-linear-gadolinium-based-contrast-agents
#19
Hirofumi Kuno, Hernán Jara, Karen Buch, Muhammad Mustafa Qureshi, Margaret N Chapman, Osamu Sakai
Purpose To assess the association of global and regional brain relaxation times in patients with prior exposure to linear gadolinium-based contrast agents (GBCAs). Materials and Methods The institutional review board approved this cross-sectional study. Thirty-five patients (nine who had received GBCA gadopentetate dimeglumine injections previously [one to eight times] and 26 patients who did not) who underwent brain magnetic resonance (MR) imaging with a mixed fast spin-echo pulse sequence were assessed. The whole brain was segmented according to white and gray matter by using a dual-clustering algorithm...
April 2017: Radiology
https://www.readbyqxmd.com/read/27755154/intrathecal-contrast-enhanced-magnetic-resonance-imaging-related-brain-signal-changes-residual-gadolinium-deposition
#20
Ali Yusuf Öner, Berrak Barutcu, Şükrü Aykol, Emin Turgut Tali
OBJECTIVES: There have been recent studies evaluating brain magnetic resonance imaging changes in patients with normal renal function, after intravenous administration of gadolinium-based contrast agents (GBCAs). Their findings were supported by histological evidence as well and brought a new vision concerning what needs to be learned to provide better patient care. In this report, we aim to present brain magnetic resonance imaging changes after intrathecal administration of a linear ionic agent (gadopentetate dimeglumine)...
October 13, 2016: Investigative Radiology
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