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Gadolinium deposition

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https://www.readbyqxmd.com/read/28501075/gadolinium-retention-and-toxicity-an-update
#1
REVIEW
Miguel Ramalho, Joana Ramalho, Lauren M Burke, Richard C Semelka
Until 2006, the main considerations regarding safety for all gadolinium-based contrast agents (GBCAs) were related to short-term adverse reactions. However, the administration of certain "high-risk" GBCAs to patients with renal failure resulted in multiple reported cases of nephrogenic systemic fibrosis. Findings have been reported regarding gadolinium deposition within the body and various reports of patients who report suffering from acute and chronic symptoms secondary to GBCA's exposure. At the present state of knowledge, it has been proved that gadolinium deposits also occur in the brain, irrespective of renal function and GBCAs stability class...
May 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28477167/cardiovascular-magnetic-resonance-myocardial-t1-mapping-to-detect-and-quantify-cardiac-involvement-in-familial-amyloid-polyneuropathy
#2
Seitaro Oda, Daisuke Utsunomiya, Kosuke Morita, Takeshi Nakaura, Hideaki Yuki, Masafumi Kidoh, Kenichiro Hirata, Narumi Taguchi, Noriko Tsuda, Shinya Shiraishi, Tomohiro Namimoto, Kyoko Hirakawa, Seiji Takashio, Yasuhiro Izumiya, Megumi Yamamuro, Seiji Hokimoto, Kenichi Tsujita, Mitsuharu Ueda, Taro Yamashita, Yukio Ando, Yasuyuki Yamashita
OBJECTIVES: This study sought to explore the potential role of non-contrast T1 mapping for the detection and quantification of cardiac involvement in familial amyloid polyneuropathy (FAP). METHODS: Japanese patients with FAP [n = 41, age 53.2 ± 13.9 years, genotype Val30Met (n = 25), non-Val30Met (n = 16)] underwent cardiac magnetic resonance imaging that included T1 mapping (saturation-recovery method) and late gadolinium-enhanced (LGE) imaging on a 3...
May 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28473338/appropriate-minimal-dose-of-gadobutrol-for-3d-time-resolved-mra-of-the-supra-aortic-arteries-comparison-with-conventional-single-phase-high-resolution-3d-contrast-enhanced-mra
#3
S H Bak, H G Roh, W-J Moon, J W Choi, H S An
BACKGROUND AND PURPOSE: The development of nephrogenic systemic fibrosis and neural tissue deposition is gadolinium dose-dependent. The purpose of this study was to determine the appropriate minimal dose of gadobutrol with time-resolved MRA to assess supra-aortic arterial stenosis with contrast-enhanced MRA as a reference standard. MATERIALS AND METHODS: Four hundred sixty-two consecutive patients underwent both standard-dose contrast-enhanced MRA and low-dose time-resolved MRA and were classified into 3 groups; group A (a constant dose of 1 mL for time-resolved MRA), group B (2 mL), or group C (3 mL)...
May 4, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28469072/uncoupling-of-the-profibrotic-and-hemostatic-effects-of-thrombin-in-lung-fibrosis
#4
Barry S Shea, Clemens K Probst, Patricia L Brazee, Nicholas J Rotile, Francesco Blasi, Paul H Weinreb, Katharine E Black, David E Sosnovik, Elizabeth M Van Cott, Shelia M Violette, Peter Caravan, Andrew M Tager
Fibrotic lung disease, most notably idiopathic pulmonary fibrosis (IPF), is thought to result from aberrant wound-healing responses to repetitive lung injury. Increased vascular permeability is a cardinal response to tissue injury, but whether it is mechanistically linked to lung fibrosis is unknown. We previously described a model in which exaggeration of vascular leak after lung injury shifts the outcome of wound-healing responses from normal repair to pathological fibrosis. Here we report that the fibrosis produced in this model is highly dependent on thrombin activity and its downstream signaling pathways...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28369631/microfabrication-of-a-gadolinium-derived-solid-state-sensor-for-thermal-neutrons
#5
Kent B Pfeifer, Komandoor E Achyuthan, Matthew Allen, Michele L B Denton, Michael P Siegal, Ronald P Manginell
Neutron sensing is critical in civilian and military applications. Conventional neutron sensors are limited by size, weight, cost, portability and helium supply. Here the microfabrication of gadolinium (Gd) conversion material-based heterojunction diodes for detecting thermal neutrons using electrical signals produced by internal conversion electrons (ICEs) is described. Films with negligible stress were produced at the tensile-compressive crossover point, enabling Gd coatings of any desired thickness by controlling the radiofrequency sputtering power and using the zero-point near p(Ar) of 50 mTorr at 100 W...
March 25, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28368880/critical-questions-regarding-gadolinium-deposition-in-the-brain-and-body-after-injections-of-the-gadolinium-based-contrast-agents-safety-and-clinical-recommendations-in-consideration-of-the-ema-s-pharmacovigilance-and-risk-assessment-committee-recommendation
#6
Val M Runge
For magnetic resonance, the established class of intravenous contrast media is the gadolinium-based contrast agents. In the 3 decades since initial approval, these have proven in general to be very safe for human administration. However, in 2006, a devastating late adverse reaction to administration of the less stable gadolinium-based contrast agents was identified, nephrogenic systemic fibrosis. The result of actions taken by the European Medicines Agency and the US Food and Drug Administration, stratifying the agents by risk and contraindicating specific agents in severe renal dysfunction, has led to no new cases being identified in North America or Europe...
June 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28367859/identification-and-assessment-of-cardiac-amyloidosis-by-myocardial-strain-analysis-of-cardiac-magnetic-resonance-imaging
#7
Seitaro Oda, Daisuke Utsunomiya, Takeshi Nakaura, Hideaki Yuki, Masafumi Kidoh, Kosuke Morita, Seiji Takashio, Megumi Yamamuro, Yasuhiro Izumiya, Kyoko Hirakawa, Toshifumi Ishida, Kenichi Tsujita, Mitsuharu Ueda, Taro Yamashita, Yukio Ando, Hiroyuki Hata, Yasuyuki Yamashita
BACKGROUND: We explored the usefulness of myocardial strain analysis on cardiac magnetic resonance imaging (CMR) scans for the identification of cardiac amyloidosis.Methods and Results:The 61 patients with systemic amyloidosis underwent 3.0-T CMR, including CMR tagging and late-gadolinium enhanced (LGE) imaging. The circumferential strain (CS) of LGE-positive and LGE-negative patients was measured on midventricular short-axis images and compared. Logistic regression modeling of CMR parameters was performed to detect patients with LGE-positive cardiac amyloidosis...
March 31, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28362042/gadolinium-contrast-agents-are-they-really-safe
#8
Hana Malikova, Michal Holesta
Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be more easily released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease...
March 28, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28361260/gadolinium-retention-in-the-body-what-we-know-and-what-we-can-do
#9
REVIEW
Enrico Tedeschi, Ferdinando Caranci, Flavio Giordano, Valentina Angelini, Sirio Cocozza, Arturo Brunetti
Gadolinium-based contrast agents (GBCA), widely used in Magnetic Resonance Imaging (MRI) for almost 30 years, were recently shown to be deposited in the brain and to induce persistent T1 shortening in deep gray matter structures in subjects with normal renal function. The aim of the present study is to summarize the evidence derived from the rapidly growing scientific literature on Gadolinium retention in the brain and in the rest of the body. To this end, the original articles that described imaging and pathology findings in humans and animals exposed to GBCA were reviewed...
March 30, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28357495/signal-intensity-change-on-unenhanced-t1-weighted-images-in-dentate-nucleus-and-globus-pallidus-after-multiple-administrations-of-gadoxetate-disodium-an-intraindividual-comparative-study
#10
Giorgio Conte, Lorenzo Preda, Emilia Cocorocchio, Sara Raimondi, Caterina Giannitto, Marta Minotti, Francesca De Piano, Giuseppe Petralia, Pier Francesco Ferrucci, Massimo Bellomi
PURPOSE: To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. MATERIALS AND METHODS: We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up...
March 29, 2017: European Radiology
https://www.readbyqxmd.com/read/28323657/histology-and-gadolinium-distribution-in-the-rodent-brain-after-the-administration-of-cumulative-high-doses-of-linear-and-macrocyclic-gadolinium-based-contrast-agents
#11
Jessica Lohrke, Anna-Lena Frisk, Thomas Frenzel, Laura Schöckel, Martin Rosenbruch, Gregor Jost, Diana Constanze Lenhard, Martin A Sieber, Volker Nischwitz, Astrid Küppers, Hubertus Pietsch
OBJECTIVES: Retrospective studies in patients with primary brain tumors or other central nervous system pathologies as well as postmortem studies have suggested that gadolinium (Gd) deposition occurs in the dentate nucleus (DN) and globus pallidus (GP) after multiple administrations of primarily linear Gd-based contrast agents (GBCAs). However, this deposition has not been associated with any adverse effects or histopathological alterations. The aim of this preclinical study was to systematically examine differences between linear and macrocyclic GBCAs in their potential to induce changes in brain and skin histology including Gd distribution in high spatial resolution...
June 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28298504/intracranial-deposition-of-intravenous-gadolinium-contrast-a-literature-review
#12
Jennifer Franco
No abstract text is available yet for this article.
March 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28283728/survey-of-gadolinium-based-contrast-agent-utilization-among-the-members-of-the-society-for-pediatric-radiology-a-quality-and-safety-committee-report
#13
Einat Blumfield, Michael M Moore, Mary K Drake, Thomas R Goodman, Kristopher N Lewis, Laura T Meyer, Thang D Ngo, Christina Sammet, Arta Luana Stanescu, David W Swenson, Thomas L Slovis, Ramesh S Iyer
BACKGROUND: Gadolinium-based contrast agents (GBCAs) have been used for magnetic resonance (MR) imaging over the last three decades. Recent reports demonstrated gadolinium retention in patients' brains following intravenous administration. Since gadolinium is a highly toxic heavy metal, there is a potential for adverse effects from prolonged retention or deposition, particularly in children. For this reason, the Society (SPR) for Pediatric Radiology Quality and Safety committee conducted a survey to evaluate the current status of GBCAs usage among pediatric radiologists...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28283727/use-of-gadolinium-based-magnetic-resonance-imaging-contrast-agents-and-awareness-of-brain-gadolinium-deposition-among-pediatric-providers-in-north-america
#14
Leena B Mithal, Payal S Patel, Divakar Mithal, Hannah L Palac, Michael N Rozenfeld
BACKGROUND: Numerous recent articles have reported brain gadolinium deposition when using linear but not macrocyclic gadolinium-based contrast agents (GBCAs). OBJECTIVE: To determine the current landscape of gadolinium use among pediatric institutions and the knowledge base of radiologists and referring providers with regard to GBCAs and brain gadolinium deposition. MATERIALS AND METHODS: We e-mailed voluntary closed surveys to 5,390 physicians in various pediatric professional societies between January 2016 and March 2016...
May 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28202695/distribution-map-of-gadolinium-deposition-within-the-cerebellum-following-gbca-administration
#15
Donna R Roberts, Cynthia A Welsh, David P LeBel, W Clay Davis
No abstract text is available yet for this article.
March 21, 2017: Neurology
https://www.readbyqxmd.com/read/28193901/exceedingly-small-iron-oxide-nanoparticles-as-positive-mri-contrast-agents
#16
He Wei, Oliver T Bruns, Michael G Kaul, Eric C Hansen, Mariya Barch, Agata Wiśniowska, Ou Chen, Yue Chen, Nan Li, Satoshi Okada, Jose M Cordero, Markus Heine, Christian T Farrar, Daniel M Montana, Gerhard Adam, Harald Ittrich, Alan Jasanoff, Peter Nielsen, Moungi G Bawendi
Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBCAs) are the mainstream MRI contrast agents used in the clinic. GBCAs have shown efficacy and are safe to use with most patients; however, some GBCAs have a small risk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recently linked to gadolinium (Gd) exposure during MRI with contrast...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28187173/the-presence-of-the-gadolinium-based-contrast-agent-depositions-in-the-brain-and-symptoms-of-gadolinium-neurotoxicity-a-systematic-review
#17
Cyprian Olchowy, Kamil Cebulski, Mateusz Łasecki, Radosław Chaber, Anna Olchowy, Krzysztof Kałwak, Urszula Zaleska-Dorobisz
BACKGROUND AND PURPOSE: Gadolinium based contrast agents (GBCAs) are widely used in magnetic resonance imaging, but recently, high signal intensity in the cerebellum structures was reported after repeated administrations of contrast- enhanced magnetic resonance images. The aim of this systematic review was to investigate the association between increased signal intensity in the dentate nucleus and globus pallidus in the brain and repeated administrations of GBCAs. Additionally, we focused on possible short- and long-term consequences of gadolinium use in those patients...
2017: PloS One
https://www.readbyqxmd.com/read/28135639/modulation-of-osteoblast-behavior-on-nanopatterned-yttria-stabilized-zirconia-surfaces
#18
Ginny Soon, Belinda Pingguan-Murphy, Sheikh Ali Akbar
This study utilizes the technique of self-assembly to fabricate arrays of nanoislands on (001)-oriented yttria-stabilized zirconia single crystal substrates with miscut of 10° toward <110> direction. These self-assembled nanostructures were annealed at 1100°C for 5h upon doping with 10mol% gadolinium-doped ceria (GDC) by powder-suspension based method. X-Ray diffraction result showed that the miscut substrate after doping GDC was in the cubic phase. Energy dispersive X-ray (EDX) illustrates that the nanopatterned material contains all the elements from the GDC source and yttria-stabilized zirconia (YSZ) substrate...
January 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28129067/radiologic-pathologic-correlation-of-primary-and-secondary-cardiomyopathies-mr-imaging-and-histopathologic-findings-in-hearts-from-autopsy-and-transplantation
#19
Hiromi Hashimura, Fumiko Kimura, Hatsue Ishibashi-Ueda, Yoshiaki Morita, Masahiro Higashi, Shintaro Nakano, Atsushi Iguchi, Kensuke Uotani, Kazuro Sugimura, Hiroaki Naito
Cardiac magnetic resonance (MR) imaging with late gadolinium enhancement (LGE) is used to detect and assess the myocardial damage seen with a variety of cardiomyopathies. Gadolinium-based contrast material accumulates in the expanded interstitial space of the myocardium. Areas with LGE correspond to replacement fibrosis, fibrofatty change, epithelioid granuloma, inflammatory cell infiltration, cardiomyocyte necrosis, and amyloid deposition-conditions that represent a focal increase in interstitial space. Areas without LGE correspond to interstitial or plexiform fibrosis, mildly degenerated cardiomyocytes, inflammatory cell infiltration, and diffuse amyloid deposition-conditions that represent diffuse increases in interstitial space...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28109895/pilot-study-of-the-mirabilis-system-prototype-for-rapid-noninvasive-uterine-myoma-treatment-using-an-ultrasound-guided-volumetric-shell-ablation-technique
#20
Jessica E Parsons, Michael P H Lau, Patrick J Martin, Joel J Islas Lagos, Juan M Aguilar Aguirre, José G Garza Leal
STUDY OBJECTIVE: The primary objective of this pilot study was to evaluate the safety and acute tissue ablation efficacy of a transabdominal high-intensity focused ultrasound (HIFU) prototype device that uses ultrasound imaging guidance for rapid noninvasive ablation of uterine myomas. The secondary objective was to assess preliminary myoma-related symptom improvement and myoma volume reduction at 3 to 6 months post-treatment in subsets of patients. DESIGN: Multicenter prospective single-arm pilot study (Canadian Task Force classification II-2)...
May 2017: Journal of Minimally Invasive Gynecology
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