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https://www.readbyqxmd.com/read/27869292/model-based-investigation-of-intracellular-processes-determining-antibody-fc-glycosylation-under-mild-hypothermia
#1
Si Nga Sou, Philip M Jedrzejewski, Ken Lee, Christopher Sellick, Karen M Polizzi, Cleo Kontoravdi
Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (qmAb ) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc-glycosylation and the mechanism behind changes in the glycan composition is not fully established. The lack of knowledge about the regulation of dynamic intracellular processes under mild hypothermia restricts bioprocess optimisation. To address this issue, a mathematical model that quantitatively describes CHO cell behaviour and metabolism, mAb synthesis and its N-linked glycosylation profiles before and after the induction of mild hypothermia is constructed using two sets of parameters...
November 21, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27643388/systematic-review-and-meta-analysis-of-collaborative-care-interventions-for-depression-in-patients-with-cancer
#2
Madeline Li, Erin B Kennedy, Nelson Byrne, Caroline Gérin-Lajoie, Mark R Katz, Homa Keshavarz, Scott Sellick, Esther Green
OBJECTIVE: Previous systematic reviews have found limited evidence for the effectiveness of pharmacological and psychological interventions for the management of depression in patients with cancer. This paper provides the first meta-analysis of newer collaborative care interventions, which may include both types of treatment, as well as integrated delivery and follow-up. Meta-analyses of pharmacological and psychological interventions are included as a comparison. METHODS: A search of MEDLINE, EMBASE, PsycINFO, and the Cochrane Library from July 2005 to January 2015 for randomized controlled trials of depression treatments for cancer patients diagnosed with a major depressive disorder, or who met a threshold on a validated depression rating scale was conducted...
September 19, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27523050/ultrasound-evaluation-of-the-impact-of-cricoid-pressure-versus-novel-paralaryngeal-pressure-on-anteroposterior-oesophageal-diameter
#3
P Andruszkiewicz, J Wojtczak, L Wroblewski, M Kaczor, D Sobczyk, I Kowalik
To assess the degree to which cricoid pressure (Sellick manoeuvre) actually compresses the oesophagus, we measured the effect of cricoid pressure and paralaryngeal pressure on the outer anteroposterior diameter of the upper oesophagus with ultrasound in 39 healthy volunteers. The mean (SD) outer anteroposterior oesophageal diameter was 0.77 (0.11) cm with no pressure, 0.79 (0.13) cm with the application of cricoid pressure of 30 N and 0.68 (0.12) cm with the application of paralaryngeal pressure of 30 N (p < 0...
September 2016: Anaesthesia
https://www.readbyqxmd.com/read/27388268/male-veterans-with-complicated-urinary-tract-infections-influence-of-a-patient-centered-antimicrobial-stewardship-program
#4
James F Carbo, Christine A Ruh, Kari E Kurtzhalts, Michael C Ott, John A Sellick, Kari A Mergenhagen
BACKGROUND: The influence of antimicrobial stewardship programs (ASPs) on outcomes in male veterans treated for complicated urinary tract infection has not been determined. METHODS: This was a retrospective cohort study encompassing the study period January 1, 2005-October 31, 2014, which was conducted at a 150-bed Veterans Affairs Healthcare System facility in Buffalo, NY. Male veterans admitted for treatment of complicated urinary tract infection were identified using ICD-9-CM codes...
December 1, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27382000/management-of-depression-in-patients-with-cancer-a-clinical-practice-guideline
#5
Madeline Li, Erin B Kennedy, Nelson Byrne, Caroline Gérin-Lajoie, Mark R Katz, Homa Keshavarz, Scott Sellick, Esther Green
PURPOSE: This report updates the Cancer Care Ontario Program in Evidence-Based Care guideline for the management of depression in adult patients with cancer. This guideline covers pharmacologic, psychological, and collaborative care interventions, with a focus on integrating practical management tools to assist clinicians in delivering appropriate treatments for depression in patients with cancer. METHODS: Recommendations were developed by synthesizing information from extant guidelines and reviews and searching for randomized controlled trials from the date of database inception (1964 for MEDLINE and 1974 for EMBASE) to January 2015...
August 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27349712/impact-of-antimicrobial-stewardship-on-outcomes-in-hospitalized-veterans-with-pneumonia
#6
Kari E Kurtzhalts, John A Sellick, Christine A Ruh, James F Carbo, Michael C Ott, Kari A Mergenhagen
PURPOSE: The purpose of this study was to evaluate the impact of an antimicrobial stewardship program (ASP) on outcomes for inpatients with pneumonia, including length of stay, treatment duration, and 30-day readmission rates. METHODS: A retrospective chart review comparing outcomes of veterans admitted with pneumonia before (2005-2006) and after (2013-2014) implementation of an ASP was conducted; pneumonia was defined according to International Classification of Diseases, Ninth Revision (ICD-9) codes...
July 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27343794/perioperative-management-of-a-morbidly-obese-pregnant-patient-undergoing-cesarean-section-under-general-anesthesia-case-report
#7
Márcio Luiz Benevides, Verônica Cristina Moraes Brandão, Jacqueline Ivonne Arenas Lovera
BACKGROUND AND OBJECTIVES: The increased prevalence of obesity in the general population extends to women of reproductive age. The aim of this study is to report the perioperative management of a morbidly obese pregnant woman, body mass index >50kg/m(2), who underwent cesarean section under general anesthesia. CASE REPORT: Pregnant woman in labor, 35 years of age, body mass index 59.8kg/m(2). Cesarean section was indicated due to the presumed fetal macrosomia...
July 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/26932201/metabolomics-reveals-the-physiological-response-of-pseudomonas-putida-kt2440-uwc1-after-pharmaceutical-exposure
#8
Felicity Currie, David I Broadhurst, Warwick B Dunn, Christopher A Sellick, Royston Goodacre
Human pharmaceuticals have been detected in wastewater treatment plants, rivers, and estuaries throughout Europe and the United States. It is widely acknowledged that there is insufficient information available to determine whether prolonged exposure to low levels of these substances is having an impact on the microbial ecology in such environments. In this study we attempt to measure the effects of exposing cultures of Pseudomonas putida KT2440 (UWC1) to six pharmaceuticals by looking at differences in metabolite levels...
April 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/26831569/impact-of-an-antimicrobial-stewardship-program-on-patient-safety-in-veterans-prescribed-vancomycin
#9
Kristen E Fodero, Amy L Horey, Michael P Krajewski, Christine A Ruh, John A Sellick, Kari A Mergenhagen
PURPOSE: This study aimed to determine the safety impact of an antimicrobial stewardship program (ASP) on vancomycin-associated nephrotoxicity and to examine risk factors contributing to the development of toxicity. METHODS: This was a retrospective chart review of data from 453 veterans receiving vancomycin in the VA Western New York Healthcare System between October 2006 and July 2014. Nephrotoxicity was defined as an increase in serum creatinine of ≥ 0.5 mg/dL or by 50% of baseline for 2 consecutive days...
March 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/26386031/reply-to-minimizing-antibiotic-misuse-through-evidence-based-management-of-outpatient-acute-respiratory-infections
#10
LETTER
Jennifer L Schroeck, Christine A Ruh, John A Sellick, Michael C Ott, Arun Mattappallil, Kari A Mergenhagen
No abstract text is available yet for this article.
October 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26198903/metabolite-profiling-of-cho-cells-molecular-reflections-of-bioprocessing-effectiveness
#11
Christopher A Sellick, Alexandra S Croxford, Arfa R Maqsood, Gill M Stephens, Hans V Westerhoff, Royston Goodacre, Alan J Dickson
Whilst development of medium and feeds has provided major advances in recombinant protein production in CHO cells, the fundamental understanding is limited. We have applied metabolite profiling with established robust (GC-MS) analytics to define the molecular loci by which two yield-enhancing feeds improve recombinant antibody yields from a model GS-CHO cell line. With data across core metabolic pathways, that report on metabolism within several cellular compartments, these data identify key metabolites and events associated with increased cell survival and specific productivity of cells...
September 2015: Biotechnology Journal
https://www.readbyqxmd.com/read/25961904/behavioral-changes-associated-with-a-disruptive-new-student-in-the-classroom
#12
Julie Stein OʼBrien, Howard Taras, Scott Barton, Pete Sellick, Martin T Stein
Marcus is a 10-year-old boy who was followed by his pediatrician for several years. She knows him as a socially engaged, active athlete, playing soccer and baseball, out-going, and a good student. He has been in good health without a significant medical history.At the beginning of this academic year, a new student was placed in Marcus's fourth grade class. This student is disruptive, impulsive, and abusive. He has frequent violent outbursts, yelling, kicking, and throwing objects, including recently throwing a desk across the room...
June 2015: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/25870064/factors-associated-with-antibiotic-misuse-in-outpatient-treatment-for-upper-respiratory-tract-infections
#13
Jennifer L Schroeck, Christine A Ruh, John A Sellick, Michael C Ott, Arun Mattappallil, Kari A Mergenhagen
The Centers for Disease Control and Prevention has promoted the appropriate use of antibiotics since 1995 when it initiated the National Campaign for Appropriate Antibiotic Use in the Community. This study examined upper respiratory tract infections included in the campaign to determine the degree to which antibiotics were appropriately prescribed and subsequent admission rates in a veteran population. This study was a retrospective chart review conducted among outpatients with a diagnosis of a respiratory tract infection, including bronchitis, pharyngitis, sinusitis, or nonspecific upper respiratory tract infection, between January 2009 and December 2011...
July 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/25748118/-perioperative-management-of-a-morbidly-obese-pregnant-patient-undergoing-cesarean-section-under-general-anesthesia-case-report
#14
Márcio Luiz Benevides, Verônica Cristina Moraes Brandão, Jacqueline Ivonne Arenas Lovera
BACKGROUND AND OBJECTIVES: The increased prevalence of obesity in the general population extends to women of reproductive age. The aim of this study is to report the perioperative management of a morbidly obese pregnant woman, body mass index > 50 kg/m(2), who underwent cesarean section under general anesthesia. CASE REPORT: Pregnant woman in labor, 35 years of age, body mass index 59.8 kg/m(2). Caesarean section was indicated due to the presumed fetal macrosomia...
July 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/25624535/comparison-of-four-techniques-of-nasogastric-tube-insertion-in-anaesthetised-intubated-patients-a-randomized-controlled-trial
#15
Mohan Chandra Mandal, Sujata Dolai, Santanu Ghosh, Pallab Kumar Mistri, Rajiv Roy, Sekhar Ranjan Basu, Sabyasachi Das
BACKGROUND AND AIMS: Insertion of nasogastric tubes (NGTs) in anaesthetised, intubated patients with a conventional method is sometimes difficult. Different techniques of NGT insertion have been tried with varying degree of success. The aim of this prospective, randomised, open-label study was to evaluate three modified techniques of NGT insertion comparing with the conventional method in respect of success rate, time taken for insertion and the adverse events. METHODS: In the operation theatre of general surgery, the patients were randomly allocated into four groups: Group C (control group, n = 54), Group W (ureteral guide wire group, n = 54), Group F (neck flexion with lateral pressure, n = 54) and Group R (reverse Sellick's manoeuvre, n = 54)...
November 2014: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/25545631/how-does-mild-hypothermia-affect-monoclonal-antibody-glycosylation
#16
Si Nga Sou, Christopher Sellick, Ken Lee, Alison Mason, Sarantos Kyriakopoulos, Karen M Polizzi, Cleo Kontoravdi
The application of mild hypothermic conditions to cell culture is a routine industrial practice used to improve recombinant protein production. However, a thorough understanding of the regulation of dynamic cellular processes at lower temperatures is necessary to enhance bioprocess design and optimization. In this study, we investigated the impact of mild hypothermia on protein glycosylation. Chinese hamster ovary (CHO) cells expressing a monoclonal antibody (mAb) were cultured at 36.5°C and with a temperature shift to 32°C during late exponential/early stationary phase...
June 2015: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/25413024/the-influence-of-two-dimensional-organization-on-peptide-conformation
#17
Simon J White, Steven D Johnson, Mark A Sellick, Agnieszka Bronowska, Peter G Stockley, Christoph Wälti
Molecular crowding plays a significant role in regulating molecular conformation in cellular environments. It is also likely to be important wherever high molecular densities are required, for example in surface-phase studies, in which molecular densities generally far exceed those observed in solution. Using on-surface circular dichroism (CD) spectroscopy, we have investigated the structure of a synthetic peptide assembled into a highly packed monolayer. The immobilized peptide undergoes a structural transition between α-helical and random coil conformation upon changes in pH and ionic concentration, but critically the threshold for conformational change is altered dramatically by molecular crowding within the peptide monolayer...
January 12, 2015: Angewandte Chemie
https://www.readbyqxmd.com/read/25303750/orotracheal-intubation-physicians-knowledge-assessment-and-clinical-practices-in-intensive-care-units
#18
Caroline Setsuko Yamanaka, Aécio Flávio Teixeira de Góis, Paulo César Bastos Vieira, Jane Cristina Dias Alves, Luciana Matias de Oliveira, Leila Blanes, Eliton Paulo Leite Lourenço, Murillo Assunção, Flavia Ribeiro Machado
OBJECTIVES: To assess the physician’s knowledge on intubation techniques and to identify the common practices. METHODS: This was a prospective study, involving three different intensive care units within a University hospital: Anesthesiology (ANEST), Pulmonology (PULMO) and Emergency Department (ED). All physicians working in these units and consenting to participate in the study completed a questionnaire with their demographic data and questions on orotracheal intubation...
June 2010: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/25029948/what-influences-malaysian-nurses-to-participate-in-continuing-professional-education-activities
#19
Mei Chan Chong, Kenneth Sellick, Karen Francis, Khatijah Lim Abdullah
PURPOSE: A cross sectional descriptive study, which involved government hospitals and health clinics from Peninsular Malaysia sought to identify the continuing professional education (CPE) needs and their readiness for E-learning. This paper focuses on the first phase of that study that aimed to determine the factors that influence nurses' participation in CPE. METHODS: Multistage cluster sampling was used to recruit 1,000 nurses randomly from 12 hospitals and 24 health clinics from four states in Peninsular Malaysia who agreed to be involved...
March 2011: Asian Nursing Research
https://www.readbyqxmd.com/read/24906015/analysing-deviation-from-target-data-applying-the-correct-force-in-sellick-s-maneuver
#20
R D Baker, R J Taylor, G Smurthwaite, G B Kitchen, I Mehmood
The problem of comparing the deviation from a target of two or more treatments or procedures arises now and again in medicine. Practitioners usually carry out a t-test on a loss function such as absolute error. We have adapted and developed statistical methods to give a normative methodology for deviation-from-target problems and exemplify them by evaluating the performance of a tactile feedback device. Parametric and nonparametric analyses are compared and contrasted. We recommend nonparametric methods for inference about loss functions such as absolute error, with a permutation test for testing the hypothesis that the two methods perform identically, and the nonparametric bootstrap for deriving standard errors and confidence intervals on loss function ratios...
2015: Journal of Biopharmaceutical Statistics
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