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Nonmotor parkinson's disease

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https://www.readbyqxmd.com/read/29053133/-ophthalmic-disorders-as-a-manifestation-of-parkinson-s-disease
#1
N B Chesnokova, T A Pavlenko, M V Ugrumov
Parkinson's disease is a severe neurodegenerative disease accompanied with the degeneration of dopaminergic neurons in the central and peripheral nervous system. The diagnosis of Parkinson's disease can still be made only on the stage of irreversible and nearly total degeneration of the nigrostriatum dopaminergic system and exhaustion of brain compensatory mechanisms that explains the low efficacy of therapy. Ophthalmic pathology is one of the nonmotor symptoms of Parkinson's disease. This can be explained firstly by the fact that eye is a 'peripheral part of brain' and secondly by the involvement of dopaminergic neurons (dopamine-producing cells) that are subject to the selective degeneration during Parkinson's disease in the regulation of visual function in the eye and brain...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29048606/contact-location-and-neuropsychological-outcomes-in-subthalamic-deep-brain-stimulation
#2
Darlene P Floden, Caio M Matias, Connor A Wathen, Grace E Ozinga, Olivia Hogue, Andre G Machado
BACKGROUND: A host of influences contribute to cognitive and behavioral changes following deep brain stimulation. The location of the active cathode is likely an important variable but it has received little attention. OBJECTIVE: To determine whether active contact location relative to the subthalamic nucleus and other neighboring structures is related to nonmotor outcomes. METHODS: We identified a retrospective, cross-sectional sample of 46 patients who underwent subthalamic nucleus deep brain stimulation for treatment of idiopathic Parkinson's disease...
October 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28986415/clinical-outcomes-of-asleep-vs-awake-deep-brain-stimulation-for-parkinson-disease
#3
Matthew A Brodsky, Shannon Anderson, Charles Murchison, Mara Seier, Jennifer Wilhelm, Aaron Vederman, Kim J Burchiel
OBJECTIVE: To compare motor and nonmotor outcomes at 6 months of asleep deep brain stimulation (DBS) for Parkinson disease (PD) using intraoperative imaging guidance to confirm electrode placement vs awake DBS using microelectrode recording to confirm electrode placement. METHODS: DBS candidates with PD referred to Oregon Health & Science University underwent asleep DBS with imaging guidance. Six-month outcomes were compared to those of patients who previously underwent awake DBS by the same surgeon and center...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28980730/cognitive-changes-in-prodromal-parkinson-s-disease-a-review
#4
REVIEW
Sophie Fengler, Inga Liepelt-Scarfone, Kathrin Brockmann, Eva Schäffer, Daniela Berg, Elke Kalbe
Although other nonmotor phenomena representing possible prodromal symptoms of Parkinson's disease have been described in some detail, the occurrence and characteristics of cognitive decline in this early phase of the disease are less well understood. The aim of this review is to summarize the current state of research on cognitive changes in prodromal PD. Only a small number of longitudinal studies have been conducted that examined cognitive function in individuals with a subsequent PD diagnosis. However, when we consider data from at-risk groups, the evidence suggests that cognitive decline may occur in a substantial number of individuals who have the potential for developing PD...
October 5, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28976016/pedestrian-safety-in-patients-with-parkinson-s-disease-a-case-control-study
#5
Kristin J Ford, Allen Joop, Raima A Memon, Kimberly H Wood, Karlene Ball, Gary R Cutter, David C Schwebel, Amy W Amara
BACKGROUND: Patients with Parkinson's disease experience debilitating motor symptoms as well as nonmotor symptoms, such as cognitive dysfunction and sleep disorders. This constellation of symptoms has the potential to negatively influence pedestrian safety. The objective of this study was to investigate the association of motor symptoms, daytime sleepiness, impaired vigilance, and cognitive dysfunction with pedestrian behavior in patients with Parkinson's disease and healthy older adults...
October 4, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28960475/impulse-control-disorders-in-advanced-parkinson-s-disease-with-dyskinesia-the-althea-study
#6
Roberta Biundo, Luca Weis, Giovanni Abbruzzese, Giovanna Calandra-Buonaura, Pietro Cortelli, Maria Cristina Jori, Leonardo Lopiano, Roberto Marconi, Angela Matinella, Francesca Morgante, Alessandra Nicoletti, Tiziano Tamburini, Michele Tinazzi, Mario Zappia, Ruxandra Julia Vorovenci, Angelo Antonini
BACKGROUND: Impulse control disorders and dyskinesia are common and disabling complications of dopaminergic treatment in Parkinson's disease. They may coexist and are possibly related. The objectives of this study were to assess the frequency and severity of impulse control disorders in Parkinson's disease patients with dyskinesia. METHODS: The ALTHEA study enrolled 251 Parkinson's disease patients with various degrees of dyskinesia severity from 11 movement disorders centers in Italy...
September 27, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28954882/caffeine-as-symptomatic-treatment-for-parkinson-disease-caf%C3%A3-pd-a-randomized-trial
#7
Ronald B Postuma, Julius Anang, Amelie Pelletier, Lawrence Joseph, Mariana Moscovich, David Grimes, Sarah Furtado, Renato P Munhoz, Silke Appel-Cresswell, Adriana Moro, Andrew Borys, Douglas Hobson, Anthony E Lang
OBJECTIVE: To assess effects of caffeine on Parkinson disease (PD). METHODS: In this multicenter parallel-group controlled trial, patients with PD with 1-8 years disease duration, Hoehn & Yahr stages I-III, on stable symptomatic therapy were randomized to caffeine 200 mg BID vs matching placebo capsules for 6-18 months. The primary research question was whether objective motor scores would differ at 6 months (Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale [MDS-UPDRS]-III, Class I evidence)...
September 27, 2017: Neurology
https://www.readbyqxmd.com/read/28953962/nonmotor-symptoms-and-parkinson-disease-in-united-states-farmers-and-spouses
#8
Srishti Shrestha, Freya Kamel, David M Umbach, Laura E Beane Freeman, Stella Koutros, Michael Alavanja, Dale P Sandler, Honglei Chen
OBJECTIVES: Few studies have evaluated the presence of multiple nonmotor symptoms (NMS) in relation to Parkinson disease (PD). Therefore, we examined cross-sectional associations between individual and multiple NMS and PD in the Agricultural Health Study. METHODS: 20,473 male farmers and 16,259 female spouses provided information on six NMS (reduced sense of smell, dream-enacting behavior, daytime sleepiness, infrequent bowel movement, depression, and anxiety) in the cohort's 2013-2015 follow-up survey...
2017: PloS One
https://www.readbyqxmd.com/read/28937033/transcranial-sonographic-alterations-of-substantia-nigra-and-third-ventricle-in-parkinson-s-disease-with-or-without-dementia
#9
Zhi-Fen Dong, Cai-Shan Wang, Ying-Chun Zhang, Ying Zhang, Yu-Jing Sheng, Hua Hu, Wei-Feng Luo, Chun-Feng Liu
BACKGROUND: Numerous studies have demonstrated that patients with Parkinson's disease (PD) have a higher prevalence of substantia nigra (SN) hyperechogenicity compared with controls. Our aim was to explore the neuroimaging characteristics of transcranial sonography (TCS) of patients with PD and those with PD with dementia (PDD). The correlation between the echogenicity of the SN and clinical symptoms in Chinese patients with PDD was also assessed. METHODS: The ratios of SN hyperechogenicity (SN+), maximum sizes of SN+, and widths of third ventricle (TV) were measured using TCS for all the recruited patients...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28918840/neuroprotective-effects-of-eexenatide-in-a-rotenone-induced-rat-model-of-parkinson-s-disease
#10
Dürdane Aksoy, Volkan Solmaz, Türker Çavuşoğlu, Ayfer Meral, Utku Ateş, Oytun Erbaş
BACKROUND: Several studies suggest an association between Parkinson's disease (PD) and type 2 diabetes mellitus; these 2 diseases are both known to affect the common molecular pathways. As a synthetic agonist for the glucagon-like peptide 1 receptor, exenatide has been evaluated as a neuroprotective agent in multiple animal models. Rotenone models of PD have great potential for the investigation of PD pathology and motor and nonmotor symptoms, as well as the role of gene-environment interactions in PD causation and pathogenesis...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28912900/open-label-trial-of-the-efficacy-and-safety-profile-of-rikkunshito-used-for-the-treatment-of-gastrointestinal-symptoms-in-patients-with-parkinson-s-disease-a-pilot-study
#11
Koji Yakabi, Naomi Yamaguchi, Shino Ono, Norihito Yoshida, Eriko Hosomi, Kenjiro Hayashi, Mitsuko Ochiai, Kosuke Maezawa, Kyoichi Nomura
BACKGROUND: Patients with Parkinson's disease (PD) usually experience distress related not only to motor dysfunction, but also to nonmotor symptoms, including gastrointestinal dysfunction. OBJECTIVE: The purpose of this pilot study was to evaluate the efficacy and safety profile of a traditional Japanese medicine, rikkunshito (RKT), used for the treatment of gastrointestinal symptoms, associated with anorexia and dyspepsia, in patients with PD. METHODS: Patients were randomly assigned to either Group A (4-week treatment period with 7...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28894620/programming-for-stimulation-induced-transient-nonmotor-psychiatric-symptoms-after-bilateral-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-s-disease
#12
Xi Wu, Yiqing Qiu, Keith Simfukwe, Jiali Wang, Jianchun Chen, Xiaowu Hu
BACKGROUND: Stimulation-induced transient nonmotor psychiatric symptoms (STPSs) are side effects following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. We designed algorithms which (1) determine the electrode contacts that induce STPSs and (2) provide a programming protocol to eliminate STPS and maintain the optimal motor functions. Our objective is to test the effectiveness of these algorithms. MATERIALS AND METHODS: 454 PD patients who underwent programming sessions after STN-DBS implantations were retrospectively analyzed...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28880414/levodopa-treatment-and-dendritic-spine-pathology
#13
REVIEW
Haruo Nishijima, Tatsuya Ueno, Yukihisa Funamizu, Shinya Ueno, Masahiko Tomiyama
Parkinson's disease (PD) is a neurodegenerative disorder associated with the progressive loss of nigrostriatal dopaminergic neurons. Levodopa is the most effective treatment for the motor symptoms of PD. However, chronic oral levodopa treatment can lead to various motor and nonmotor complications because of nonphysiological pulsatile dopaminergic stimulation in the brain. Examinations of autopsy cases with PD have revealed a decreased number of dendritic spines of striatal neurons. Animal models of PD have revealed altered density and morphology of dendritic spines of neurons in various brain regions after dopaminergic denervation or dopaminergic denervation plus levodopa treatment, indicating altered synaptic transmission...
September 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28877102/treadmill-exercise-modifies-dopamine-receptor-expression-in-the-prefrontal-cortex-of-the-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-lesioned-mouse-model-of-parkinson-s-disease
#14
Natalie Kintz, Giselle M Petzinger, Michael W Jakowec
Parkinson's disease (PD) is the second most common neurodegenerative disorder for which there is no cure. PD is a dopamine (DA)-deficit disorder marked by progressive motor and nonmotor disturbances, including cognitive impairment. Executive function (EF) is the most common subtype of cognitive impairment in PD and consists of deficits in number of processes including behavioral flexibility. The prefrontal cortex (PFC) is an important brain region subserving EF. Furthermore, DA plays a key neuromodulatory role in the PFC and altered DA neurotransmission is believed to contribute toward EF deficits in PD...
September 4, 2017: Neuroreport
https://www.readbyqxmd.com/read/28861502/cannabinoids-in-parkinson-s-disease
#15
REVIEW
Mario Stampanoni Bassi, Andrea Sancesario, Roberta Morace, Diego Centonze, Ennio Iezzi
The endocannabinoid system plays a regulatory role in a number of physiological processes and has been found altered in different pathological conditions, including movement disorders. The interactions between cannabinoids and dopamine in the basal ganglia are remarkably complex and involve both the modulation of other neurotransmitters (γ-aminobutyric acid, glutamate, opioids, peptides) and the activation of different receptors subtypes (cannabinoid receptor type 1 and 2). In the last years, experimental studies contributed to enrich this scenario reporting interactions between cannabinoids and other receptor systems (transient receptor potential vanilloid type 1 cation channel, adenosine receptors, 5-hydroxytryptamine receptors)...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/28859333/%C3%AE-synucleinopathy-in-the-human-amygdala-in-parkinson-disease-differential-vulnerability-of-somatostatin-and-parvalbumin-expressing-neurons
#16
Alicia Flores-Cuadrado, Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Alino Martinez-Marcos
Olfactory dysfunction and emotional impairment are nonmotor symptoms in Parkinson disease (PD). These symptoms might be correlated with the appearance of Lewy bodies and neurites (ubiquitin and α-synuclein aggregates) in the amygdala (Braak stage 3). α-Synucleinopathy in the amygdala has been studied only occasionally, and no data on cell types involved are available. This work aimed to analyze α-synuclein expression in the basolateral, central, and cortical amygdaloid nuclei in 5 PD patients (Braak stages 3-5) and 5 controls...
September 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28843021/the-nasal-and-gut-microbiome-in-parkinson-s-disease-and-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#17
Anna Heintz-Buschart, Urvashi Pandey, Tamara Wicke, Friederike Sixel-Döring, Annette Janzen, Elisabeth Sittig-Wiegand, Claudia Trenkwalder, Wolfgang H Oertel, Brit Mollenhauer, Paul Wilmes
BACKGROUND: Increasing evidence connects the gut microbiota and the onset and/or phenotype of Parkinson's disease (PD). Differences in the abundances of specific bacterial taxa have been reported in PD patients. It is, however, unknown whether these differences can be observed in individuals at high risk, for example, with idiopathic rapid eye movement sleep behavior disorder, a prodromal condition of α-synuclein aggregation disorders including PD. OBJECTIVES: To compare microbiota in carefully preserved nasal wash and stool samples of subjects with idiopathic rapid eye movement sleep behavior disorder, manifest PD, and healthy individuals...
August 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28831326/dynamic-changes-in-the-nigrostriatal-pathway-in-the-mptp-mouse-model-of-parkinson-s-disease
#18
REVIEW
Dongping Huang, Jing Xu, Jinghui Wang, Jiabin Tong, Xiaochen Bai, Heng Li, Zishan Wang, Yulu Huang, Yufei Wu, Mei Yu, Fang Huang
The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's disease (PD) are well established. However, the details regarding the causes of the disease and its course are much less clear. Animal models have significantly enriched our current understanding of the progression of this disease. Among various neurotoxin-based models of PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model is the most commonly studied model. Here, we provide an overview of the dynamic changes in the nigrostriatal pathway in the MPTP mouse model of PD...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28828219/long-term-safety-and-effectiveness-of-levodopa-carbidopa-intestinal-gel-infusion
#19
Oriol De Fabregues, Joan Dot, Monder Abu-Suboh, Jorge Hernández-Vara, Alex Ferré, Odile Romero, Marta Ibarria, José Luis Seoane, Nuria Raguer, Carolina Puiggros, Maria Rosa Gómez, Manuel Quintana, Josep Ramon Armengol, José Alvarez-Sabín
INTRODUCTION: Levodopa-carbidopa intestinal gel (LCIG) infusion has demonstrated to improve motor fluctuations. The aim of this study is to assess the long-term safety and effectiveness of LCIG infusion in advanced Parkinson's disease (PD) patients with motor fluctuations and its effect in nonmotor symptoms. METHODS: Adverse events (AE) and their management, clinical motor, and nonmotor aspects were assessed up to 10 years. Thirty-seven patients were treated with LGIC; in three subsets of patients, specific batteries of tests were used to assess cognitive and behavior assessment for 6 months, quality of sleep for 6 months, and quality of life and caregiver burden for 1 year...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28819579/dual-task-performance-in-gba-parkinson-s-disease
#20
Karin Srulijes, Kathrin Brockmann, Senait Ogbamicael, Markus A Hobert, Ann-Kathrin Hauser, Claudia Schulte, Jasmin Fritzen, Michael Schwenk, Thomas Gasser, Daniela Berg, Walter Maetzler
INTRODUCTION: Parkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients. METHODS: Eleven GBA-PD patients (p...
2017: Parkinson's Disease
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