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Nonmotor parkinson's disease

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https://www.readbyqxmd.com/read/29438043/selective-cognitive-impairment-and-hyposmia-in-p-a53t-snca-pd-vs-typical-pd
#1
Christos Koros, Maria Stamelou, Athina Simitsi, Ion Beratis, Dimitra Papadimitriou, Nikolaos Papagiannakis, Stella Fragkiadaki, Dionysia Kontaxopoulou, Sokratis G Papageorgiou, Leonidas Stefanis
OBJECTIVE: To evaluate nonmotor symptoms in early SNCA /p.A53T Parkinson disease (PD) (A53T PD) compared to typical PD (tPD). METHODS: The presence of hyposmia, neuropsychiatric, dysautonomic, and sleep disturbances was assessed by standardized questionnaires and validated scales in 18 patients with A53T PD and 18 patients with tPD, matched for age, sex, and disease duration. All patients were enrolled into the Parkinson's Progression Markers Initiative study. RESULTS: The levodopa equivalent daily dose was higher in the A53T PD ( p = 0...
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29407467/neuroprotective-effects-of-voluntary-running-on-cognitive-dysfunction-in-an-%C3%AE-synuclein-rat-model-of-parkinson-s-disease
#2
Erin K Crowley, Yvonne M Nolan, Aideen M Sullivan
Parkinson's disease (PD) is no longer primarily classified as a motor disorder due to increasing recognition of the impact on patients of several nonmotor PD symptoms, including cognitive dysfunction. These nonmotor symptoms are highly prevalent and greatly affect the quality of life of patients with PD, and so, therapeutic interventions to alleviate these symptoms are urgently needed. The aim of this study was to investigate the potential neuroprotective effects of voluntary running on cognitive dysfunction in an adeno-associated virus-α-synuclein rat model of PD...
February 2, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29406302/brief-report-knowledge-of-interest-in-and-willingness-to-try-behavioral-interventions-in-individuals-with-parkinson-s-disease
#3
Jared F Benge, R Lynae Roberts, Zoltan Kekecs, Gary Elkins
Purpose/Objective • Behavioral interventions hold enormous promise for managing a variety of motor and nonmotor symptoms in Parkinson's disease (PD). Despite this, prior studies have suggested that the utilization of these interventions is relatively low. The current study seeks to understand factors that could relate to the utilization of PD behavioral strategies. Specifically, the study evaluates the self-described knowledge of, interest in, and willingness to participate in behavioral interventions in a community-dwelling sample of individuals with PD...
January 2018: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29396191/sarcopenia-in-parkinson-disease-comparison-of-different-criteria-and-association-with-disease-severity
#4
Davide L Vetrano, Maria S Pisciotta, Alice Laudisio, Maria R Lo Monaco, Graziano Onder, Vincenzo Brandi, Domenico Fusco, Beatrice Di Capua, Diego Ricciardi, Roberto Bernabei, Giuseppe Zuccalà
OBJECTIVES: In Parkinson disease (PD), sarcopenia may represent the common downstream pathway that from motor and nonmotor symptoms leads to the progressive loss of resilience, frailty, and disability. Here we (1) assessed the prevalence of sarcopenia in older adults with PD using 3 different criteria, testing their agreement, and (2) evaluated the association between PD severity and sarcopenia. DESIGN: Cross-sectional, observation study. SETTING: Geriatric day hospital...
January 30, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29394208/caring-interactions-in-secondary-prevention-programs-a-qualitative-inquiry-of-individuals-with-parkinson-s-disease
#5
Lindsey E Greviskes, Leslie Podlog, Maria Newton, Leland E Dibble, Ryan D Burns, Wanda Pillow, Morgan S Hall, Christopher Hammer
BACKGROUND AND PURPOSE: With Parkinson's disease (PD) prevalence rates steadily increasing and long-term adherence to regular physical activity and exercise often difficult to achieve, it is imperative to investigate factors promoting adherence to secondary prevention programs (SPP) that help limit the progression of motor and nonmotor signs and symptoms of the disease. Caring interactions between patients and their rehabilitation team may be particularly germane to individuals with PD, given the physical and psychosocial issues that often accompany this disease (eg, loss of physical function, depression, apathy, and cognitive impairments)...
February 1, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29392774/gait-initiation-is-influenced-by-emotion-processing-in-parkinson-s-disease-patients-with-freezing
#6
Giovanna Lagravinese, Elisa Pelosin, Gaia Bonassi, Federico Carbone, Giovanni Abbruzzese, Laura Avanzino
BACKGROUND: Freezing of gait is a symptom that affects more than 50% of Parkinson's disease (PD) patients and increasing evidence suggests that nonmotor systems (i.e., limbic system) are involved in its underlying mechanisms. OBJECTIVE: The objective of this study was to investigate whether gait initiation characteristics are influenced by emotional stimuli in patients with PD, with or without freezing of gait. METHODS: A total of 44 participants, divided into 3 groups (15 PD patients with and 15 PD patients without freezing of gait and 14 controls), stood on a sensorized mat and were asked to take a step forward in response to a pleasant image and a step backward in response to an unpleasant one (congruent task, low cognitive load) or to take a step backward in response to a pleasant image and a step forward in response to an unpleasant one (incongruent task, high cognitive load)...
February 2, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29392459/patient-centered-integrated-healthcare-improves-quality-of-life-in-parkinson-s-disease-patients-a-randomized-controlled-trial
#7
Carsten Eggers, R Dano, J Schill, G R Fink, M Hellmich, L Timmermann
INTRODUCTION: Improving quality of life (QoL) is a key issue when dealing with Parkinson's disease (PD). Integrative care shows potential to achieve improvements in QoL. Here, we analyzed whether a community-based, open-label, integrated approach improves QoL in PD patients. METHODS: PD patients were screened for eligibility and evaluated by a university-based PD specialist, a PD nurse, and a general neurologist at a local practice. Patients were randomly assigned to a control group (CG), receiving standard German neurological treatment including a baseline assessment and follow-up visit at 6 months, or an interventional group (IG) who received an individually tailored therapy plan and additional home visits...
February 1, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29390272/efficacy-and-safety-of-sqjz-herbal-mixtures-on-nonmotor-symptoms-in-parkinson-disease-patients-protocol-for-a-randomized-double-blind-placebo-controlled-trial
#8
Jing Shi, Jinzhou Tian, Ting Li, Bin Qin, Dongsheng Fan, Jingnian Ni, Mingqing Wei, Xuekai Zhang, Na Liu, Jianping Liu, Yumeng Li, Weiwei Liu, Yongyan Wang
BACKGROUND: As a multisystemic neurodegenerative disorder, Parkinson disease (PD) has a broad spectrum of symptoms including motor and nonmotor symptoms (NMS). As shown in studies, NMS can also impact patient's quality of life, and many of them often go untreated. Chinese herbal medicines with multiconstituent may alleviate NMS in PD patients. This research is carried out to assess the efficacy and safety of a Chinese herbal formula for NMS, with its Chinese name acronym of SQJZ. METHODS/DESIGN: It will be a multicenter, randomized, double-blind, placebo-controlled trial...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384860/bilateral-subthalamic-deep-brain-stimulation-initial-impact-on-nonmotor-and-motor-symptoms-in-parkinson-s-disease-an-open-prospective-single-institution-study
#9
Sandra Kurcova, Jan Bardon, Miroslav Vastik, Marketa Vecerkova, Monika Frolova, Lenka Hvizdosova, Martin Nevrly, Katerina Mensikova, Pavel Otruba, David Krahulik, Egon Kurca, Stefan Sivak, Jana Zapletalova, Petr Kanovsky
Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains.Our objective was to elucidate the initial effects of STN-DBS on non-motor and motor symptoms in PD patients in a 4-month follow-up.This open prospective study followed 24 patients with PD who underwent STN-DBS. The patients were examined using dedicated rating scales preoperatively and at 1 and 4 months following STN-DBS to determine initial changes in motor and nonmotor symptoms...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380907/dopamine-reuptake-transporter-single-photon-emission-computed-tomography-and-transcranial-sonography-as-imaging-markers-of-prediagnostic-parkinson-s-disease
#10
Alastair J Noyce, John Dickson, Richard N Rees, Jonathan P Bestwick, Ioannis U Isaias, Marios Politis, Gavin Giovannoni, Thomas T Warner, Andrew J Lees, Anette Schrag
OBJECTIVE: The objective of this study was to examine whether prediagnostic features of Parkinson's disease (PD) were associated with changes in dopamine reuptake transporter-single-photon emission computed tomography and transcranial sonography. METHODS: Prediagnostic features of PD (risk estimates, University of Pennsylvania Smell Identification Test, Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire, and finger-tapping scores) were assessed in a large cohort of older U...
January 30, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29356826/globus-pallidus-interna-or-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-disease-a-review
#11
Adolfo Ramirez-Zamora, Jill L Ostrem
Importance: Selection of the best deep brain stimulation (DBS) target-subthalamic nucleus (STN) or globus pallidus interna (GPi)-for treatment of motor complications in Parkinson disease remains a matter of debate. Observations: Increasing evidence from randomized clinical trials indicates that motor benefit is similar between both targets, including an effect on dyskinesia and improvement in quality of life. Deep brain stimulation of the STN offers consistently greater dopaminergic medication reduction, possible mild benefit in nonmotor domains, and potential economic advantage...
January 22, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29350301/constipation-in-parkinson-s-disease-a-nuisance-or-nuanced-answer-to-the-pathophysiological-puzzle
#12
REVIEW
Amol Sharma, Julie Kurek, John C Morgan, Chandramohan Wakade, Satish S C Rao
PURPOSE OF REVIEW: Chronic constipation is a common, nonmotor, and prodromal symptom in Parkinson's disease (PD). Its underlying neuropathology may provide pathophysiological insight into PD. Here, we critically review what is currently known about the neuroanatomical and brain-gut interactions, and the origin and progression of Lewy pathology (LP) at three levels-brain/brainstem, spinal cord, and enteric nervous system. RECENT FINDINGS: Many recent studies have illustrated the challenges of examining LP in tissues obtained from colon biopsies of PD patients...
January 19, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29332071/clinical-presentation-and-prognosis-of-common-movement-disorders
#13
Jennifer Han, Samay Jain
Great progress has been made in expanding our understanding of the natural history of movement disorders, leading to impressive advancements in their medical and surgical management. Movement disorders are a diverse group of diseases, varying widely in clinical characteristics and evolution. Some are monosymptomatic while others have associated motor and nonmotor features. Some are static while others follow a progressive course. This chapter will review common primary and secondary movement disorders: Parkinson disease and other forms of Parkinsonism, essential tremor and its differential diagnoses, dystonia and tic disorders...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29327219/pharmacological-insights-into-the-use-of-apomorphine-in-parkinson-s-disease-clinical-relevance
#14
REVIEW
Manon Auffret, Sophie Drapier, Marc Vérin
The present paper consists of a comprehensive review of the literature on apomorphine pharmacological properties and its usefulness in Parkinson's disease (PD). The chemistry, structure-activity relationship, pharmacokinetics and pharmacodynamics of apomorphine are described with regard to its effects on PD symptoms, drug interactions, interindividual variability and adverse events. Apomorphine chemical structure accounts for most of its beneficial and deleterious properties, both dopaminergic and non-dopaminergic...
January 11, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29327199/glycogen-synthase-kinase-3%C3%AE-regulates-equilibrium-between-neurogenesis-and-gliogenesis-in-rat-model-of-parkinson-s-disease-a-crosstalk-with-wnt-and-notch-signaling
#15
Sonu Singh, Akanksha Mishra, Sachi Bharti, Virendra Tiwari, Jitendra Singh, Parul, Shubha Shukla
Neurogenesis involves generation of functional newborn neurons from neural stem cells (NSCs). Insufficient formation or accelerated degeneration of newborn neurons may contribute to the severity of motor/nonmotor symptoms of Parkinson's disease (PD). However, the functional role of adult neurogenesis in PD is yet not explored and whether glycogen synthase kinase-3β (GSK-3β) affects multiple steps of adult neurogenesis in PD is still unknown. We investigated the possible underlying molecular mechanism of impaired adult neurogenesis associated with PD...
January 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29324447/characteristic-motor-and-nonmotor-symptoms-related-to-quality-of-life-in-drug-na%C3%A3-ve-patients-with-late-onset-parkinson-disease
#16
Hea Ree Park, Jinyoung Youn, Jin Whan Cho, Eung-Seok Oh, Ji Sun Kim, Suyeon Park, Wooyoung Jang, Jin Se Park
BACKGROUND/AIMS: Unlike young-onset Parkinson disease (YOPD), characteristics of late-onset PD (LOPD) have not yet been clearly elucidated. We investigated characteristic features and symptoms related to quality of life (QoL) in LOPD patients. METHODS: We recruited drug-naïve, early PD patients. The patient cohort was divided into 3 subgroups based on patient age at onset (AAO): the YOPD group (AAO <50 years), the middle-onset PD (MOPD) group, and the LOPD group (AAO ≥70 years)...
January 12, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29205509/cerebrospinal-fluid-plasma-and-saliva-in-the-biofind-study-relationships-among-biomarkers-and-parkinson-s-disease-features
#17
Jennifer G Goldman, Howard Andrews, Amy Amara, Anna Naito, Roy N Alcalay, Leslie M Shaw, Peggy Taylor, Tao Xie, Paul Tuite, Claire Henchcliffe, Penelope Hogarth, Samuel Frank, Marie-Helene Saint-Hilaire, Mark Frasier, Vanessa Arnedo, Alyssa N Reimer, Margaret Sutherland, Christine Swanson-Fischer, Katrina Gwinn, Un Jung Kang
OBJECTIVE: Examine relationships among neurodegenerative biomarkers and PD motor and nonmotor symptoms. BACKGROUND: CSF alpha-synuclein is decreased in PD versus healthy controls, but whether plasma and saliva alpha-synuclein differentiate these groups is controversial. Correlations of alpha-synuclein among biofluids (CSF, plasma, saliva) or biomarkers (eg, beta-amyloid, tau [total, phosphorylated]) are not fully understood. The relationships of these biomarkers with PD clinical features remain unclear...
December 4, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29191070/predictors-of-mortality-in-nondemented-patients-with-parkinson-disease-motor-symptoms-versus-nonmotor-symptoms
#18
D Santos-García, E Suárez-Castro, J Ernandez, I Expósito-Ruiz, C Tuñas-Gesto, M Aneiros-Díaz, T de Deus-Fonticoba, M López-Fernández, D Núñez-Arias
BACKGROUND AND OBJECTIVE: The aim of this study is to identify risk factors for mortality in a community-based cohort of nondemented patients with Parkinson disease (PD) during prospective long-term follow-up, while also comparing the effect of motor complications to nonmotor symptoms (NMS) on risk of mortality. METHODS: One hundred forty seven nondemented patients with PD (57.1% males; 70.9 ± 8.6 years old) were included in this 48 month follow-up, longitudinal, single, evaluation study...
January 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29183233/complex-dynamics-in-the-basal-ganglia-health-and-disease-beyond-the-motor-system
#19
Daniela S Andres, Olivier Darbin
The rate and oscillatory hypotheses are the two main current frameworks of basal ganglia pathophysiology. Both hypotheses have emerged from research on movement disorders sharing similar conceptualizations. These pathological conditions are classified either as hypokinetic or hyperkinetic, and the electrophysiological hallmarks of basal ganglia dysfunction are categorized as prokinetic or antikinetic. Although nonmotor symptoms, including neurobehavioral symptoms, are a key manifestation of basal ganglia dysfunction, they are uncommonly accounted for in these models...
November 29, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29168899/global-scales-for-cognitive-screening-in-parkinson-s-disease-critique-and-recommendations
#20
REVIEW
Matej Skorvanek, Jennifer G Goldman, Marjan Jahanshahi, Connie Marras, Irena Rektorova, Ben Schmand, Erik van Duijn, Christopher G Goetz, Daniel Weintraub, Glenn T Stebbins, Pablo Martinez-Martin
BACKGROUND: Cognitive impairment is a common nonmotor manifestation of Parkinson's disease, with deficits ranging from mild cognitive difficulties in 1 or more of the cognitive domains to severe dementia. The International Parkinson and Movement Disorder Society commissioned the assessment of the clinimetric properties of cognitive rating scales measuring global cognitive performance in PD to make recommendations regarding their use. METHODS: A systematic literature search was conducted to identify the scales used to assess global cognitive performance in PD, and the identified scales were reviewed and rated as "recommended," "recommended with caveats," "suggested," or "listed" by the panel using previously established criteria...
November 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
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