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Nonmotor parkinson's disease

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https://www.readbyqxmd.com/read/28324303/subtypes-of-parkinson-s-disease-what-do-they-tell-us-about-disease-progression
#1
REVIEW
Seyed-Mohammad Fereshtehnejad, Ronald B Postuma
Parkinson's disease is a widely heterogeneous disorder with a broad list of motor and nonmotor manifestations. Identifying subtypes of Parkinson's disease is one of the top clinical and research priorities. This review aims to summarize the most valid conventional and recent subtyping solutions that have been introduced so far and to update our current knowledge with recent discoveries on the association between subtypes and disease progression. We also discuss the challenges of subtyping in the context of Parkinson's disease, stability of the subtypes over time, and potential clinical implications...
April 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28279596/clinical-manifestations-of-nonmotor-symptoms-in-1021-japanese-parkinson-s-disease-patients-from-35-medical-centers
#2
Tetsuya Maeda, Yasushi Shimo, Shih-Wei Chiu, Takuhiro Yamaguchi, Kenichi Kashihara, Yoshio Tsuboi, Masahiro Nomoto, Nobutaka Hattori, Hirohisa Watanabe, Hidemoto Saiki
INTRODUCTION: We aimed to investigate the prevalence and severity of nonmotor symptoms (NMSs) and to identify factors affecting NMSs and the health-related quality of life of Japanese patients with Parkinson's disease (PD). METHODS: A total of 1021 patients with PD who had one or more NMS and showed wearing-off under anti-parkinsonian treatment were enrolled from 35 medical centers in Japan for this observational study. The primary measurements were the Movement Disorder Society unified Parkinson's disease rating scale (MDS-UPDRS) part I and the Parkinson's Disease Questionnaire (PDQ-8)...
February 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28263256/factors-associated-with-ambulatory-activity-in-de-novo-parkinson-disease
#3
Cory Christiansen, Charity Moore, Margaret Schenkman, Benzi Kluger, Wendy Kohrt, Anthony Delitto, Brian Berman, Deborah Hall, Deborah Josbeno, Cynthia Poon, Julie Robichaud, Toby Wellington, Samay Jain, Cynthia Comella, Daniel Corcos, Ed Melanson
BACKGROUND AND PURPOSE: Objective ambulatory activity during daily living has not been characterized for people with Parkinson disease prior to initiation of dopaminergic medication. Our goal was to characterize ambulatory activity based on average daily step count and examine determinants of step count in nonexercising people with de novo Parkinson disease. METHODS: We analyzed baseline data from a randomized controlled trial, which excluded people performing regular endurance exercise...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28243481/stigma-experienced-by-parkinson-s-disease-patients-a-descriptive-review-of-qualitative-studies
#4
REVIEW
Marina Maffoni, Anna Giardini, Antonia Pierobon, Davide Ferrazzoli, Giuseppe Frazzitta
Parkinson's disease (PD) is a neurodegenerative disease characterized by motor and nonmotor symptoms. Both of them imply a negative impact on Health-Related Quality of Life. A significant one is the stigma experienced by the parkinsonian patients and their caregivers. Moreover, stigma may affect everyday life and patient's subjective and relational perception and it may lead to frustration and isolation. Aim of the present work is to qualitatively describe the stigma of PD patients stemming from literature review, in order to catch the subjective experience and the meaning of the stigma construct...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28241159/timed-light-therapy-for-sleep-and-daytime-sleepiness-associated-with-parkinson-disease-a-randomized-clinical-trial
#5
Aleksandar Videnovic, Elizabeth B Klerman, Wei Wang, Angelica Marconi, Teresa Kuhta, Phyllis C Zee
Importance: Impaired sleep and alertness are some of the most common nonmotor manifestations of Parkinson disease (PD) and currently have only limited treatment options. Light therapy (LT), a widely available treatment modality in sleep medicine, has not been systematically studied in the PD population. Objective: To determine the safety and efficacy of LT on excessive daytime sleepiness (EDS) associated with PD. Design, Settings, and Participants: This randomized, placebo-controlled, clinical intervention study was set in PD centers at Northwestern University and Rush University...
February 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28237854/a-randomized-trial-of-relamorelin-for-constipation-in-parkinson-s-disease-move-pd-trial-results-and-lessons-learned
#6
Ronald F Pfeiffer
BACKGROUND: Bowel dysfunction, including both slow transit constipation and defecatory dysfunction, is a frequent and often troubling nonmotor manifestation of Parkinson's disease (PD). A variety of agents are employed for the treatment of constipation in PD, but dissatisfaction with available treatment approaches is common. Relamorelin is a synthetic ghrelin agonist that has demonstrated prokinetic properties within the gastrointestinal tract. METHODS: We carried out a multi-center, randomized, double-blind, placebo-controlled study of relamorelin in patients with PD experiencing chronic, inadequately controlled constipation...
February 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28228566/reduced-cognitive-function-in-patients-with-parkinson-disease-and-obstructive-sleep-apnea
#7
Victoria P Mery, Priti Gros, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, R John Kimoff, Marta Kaminska
OBJECTIVE: To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD). METHODS: Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn & Yahr (H&Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#8
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28212928/nonmotor-symptoms-in-de-novo-parkinson-disease-comparing-to-normal-aging
#9
Petra Bago Rožanković, Marjan Rožanković, Lovorka Vučak Novosel, Maristela Stojić
OBJECTIVE: Nonmotor symptoms (NMSs) are common in Parkinson disease (PD), affecting patient's quality of life. The prevalence and domains of NMSs in untreated de novo PD remains unclear, especially comparing to normal aging. The objective was to determine NMSs in untreated de novo PD patients. PATIENTS AND METHODS: We performed a cross-sectional study to evaluate the frequency and severity of NMSs in untreated de novo PD patients (n=71) and age-matched normal controls (n=60) using the Non-Motor Symptoms Scale (NMSS)...
February 11, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28203083/sexual-dimorphism-in-parkinson-s-disease-differences-in-clinical-manifestations-quality-of-life-and-psychosocial-functioning-between-males-and-females
#10
Farzaneh Farhadi, Kia Vosoughi, Gholam Ali Shahidi, Ahmad Delbari, Johan Lökk, Seyed-Mohammad Fereshtehnejad
INTRODUCTION: Sex-related differences in clinical manifestations and consequences of Parkinson's disease (PD) have been poorly explored. Better understanding of sexual dimorphism in neurologic diseases such as PD has been announced as a research priority. The aim of our study was to determine independent sex differences in clinical manifestations and subtypes, psychosocial functioning, quality of life (QoL) and its domains between male and female individuals with PD. PATIENTS AND METHODS: A comprehensive list of demographics, motor symptoms and subtypes, nonmotor features, health-related quality of life (HRQoL), psychosocial functioning and general aspects of daily life was assessed in 157 individuals (108 males and 49 females) with idiopathic PD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28202664/lrrk2-mouse-models-dissecting-the-behavior-striatal-neurochemistry-and-neurophysiology-of-pd-pathogenesis
#11
REVIEW
Mattia Volta, Heather Melrose
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of familial Parkinson's disease (PD), resembling the sporadic disorder. Intensive effort has been directed toward LRRK2 mouse modeling and investigation, aimed at reproducing the human disease to inform mechanistic studies of pathogenesis and design of neuroprotective therapies. The physiological function of LRRK2 is still under exploration, but a clear role in striatal neurophysiology and animal behavior has emerged. Alterations in LRRK2 impair dopamine (DA) transmission, regulation and signaling, in addition to corticostriatal synaptic plasticity...
February 8, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28186662/blepharospasm-40-years-later
#12
REVIEW
Giovanni Defazio, Mark Hallett, Hyder A Jinnah, Antonella Conte, Alfredo Berardelli
Forty years ago, C.D. Marsden proposed that blepharospasm should be considered a form of adult-onset focal dystonia. In the present paper, we provide a comprehensive overview of the findings regarding blepharospasm reported in the past 40 years. Although prolonged spasms of the orbicularis oculi muscles remain the clinical hallmark of blepharospasm, patients with blepharospasm may be characterized by various types of involuntary activation of periocular muscles. In addition to motor features, blepharospasm patients may also have nonmotor manifestations, including psychiatric, mild cognitive, and sensory disturbances...
February 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28123288/spotlight-on-opicapone-as-an-adjunct-to-levodopa-in-parkinson-s-disease-design-development-and-potential-place-in-therapy
#13
REVIEW
Ádám Annus, László Vécsei
Parkinson's disease (PD) is a progressive, chronic, neurodegenerative disease characterized by rigidity, tremor, bradykinesia and postural instability secondary to dopaminergic deficit in the nigrostriatal system. Currently, disease-modifying therapies are not available, and levodopa (LD) treatment remains the gold standard for controlling motor and nonmotor symptoms of the disease. LD is extensively and rapidly metabolized by peripheral enzymes, namely, aromatic amino acid decarboxylase and catechol-O-methyltransferase (COMT)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28116784/management-of-sleep-disorders-in-parkinson-s-disease-and-multiple-system-atrophy
#14
REVIEW
Aleksandar Videnovic
Parkinson's disease (PD) and multiple system atrophy (MSA) are disorders associated with α synuclein-related neurodegeneration. Nonmotor symptoms are common hallmarks of these disorders, and disturbances of the sleep-wake cycle are among the most common nonmotor symptoms. It is only recently that sleep disturbances have received the attention of the medical and research community. Significant progress has been made in understanding the pathophysiology of sleep and wake disruption in alphasynucleinopathies during the past few decades...
January 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28108020/hallucinations-and-the-spectrum-of-psychosis-in-parkinson-s-disease
#15
REVIEW
Karen Frei, Daniel D Truong
Hallucinations and psychosis can be a part of Parkinson's disease and are considered to be a nonmotor symptom or a neuropsychiatric complication of the disease. Hallucinations of different modalities and delusions can occur beyond the common visual hallucinations. The various types of hallucinations and psychotic symptoms comprising the spectrum of Parkinson's disease psychosis is the subject of this review article.
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28087059/fatigue-in-parkinson-s-disease
#16
REVIEW
Karen Herlofson, Benzi M Kluger
Fatigue is one of the most common nonmotor symptoms in Parkinson's disease and may affect a wide range of everyday activities, cause disability and reduce quality of life. It occurs at every stage of PD, and once present will often persist and may worsen over time. Lack of a consensus of definition and classification, and a range of different self-reporting scales has so far made the study of fatigue challenging. We review a unifying taxonomy for defining fatigue in clinical and research contexts as well as case definition criteria for PD-related fatigue...
March 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28073327/nonmotor-symptoms-in-parkinson-disease
#17
Rosanna Palmeri, Viviana Lo Buono, Francesco Corallo, Maria Foti, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino
Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms. Nonmotor symptoms include cognitive deficits and impairment in emotions recognition ability associated with loss of dopaminergic neurons in the substantia nigra and with alteration in frontostriatal circuits. In this review, we analyzed the studies on social cognition ability in patients with PD. We searched on PubMed and Web of Science databases and screening references of included studied and review articles for additional citations...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28017228/apomorphine-pump-in-advanced-parkinson-s-disease-effects-on-motor-and-nonmotor-symptoms-with-brain-metabolism-correlations
#18
Manon Auffret, Florence Le Jeune, Anne Maurus, Sophie Drapier, Jean-François Houvenaghel, Gabriel Hadrien Robert, Paul Sauleau, Marc Vérin
INTRODUCTION: Patients with advanced Parkinson's disease (PD) and contraindications for subthalamic nucleus deep brain stimulation (DBS) could particularly benefit from subcutaneous infusion therapy with apomorphine. This original study was designed to evaluate the general efficacy of add-on apomorphine in motor and nonmotor symptoms in advanced PD, while characterizing the changes induced in brain glucose metabolism. The aim was to look at the underlying anatomical-functional pathways...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27998652/the-need-for-non-oral-therapy-in-parkinson-s-disease-a-potential-role-for-apomorphine
#19
Teus van Laar, Robbert Borgemeester
In the course of Parkinson's disease (PD), oral medication may lose its effectiveness due to several reasons, like dysphagia, impaired absorption from the gastro-intestinal tract and delayed emptying of the stomach. If these problems occur, a non-oral therapy should be considered. Examples of non-oral therapies are transdermal patches, (e.g. rotigotine) which may overcome motor and nonmotor nighttime problems, and may serve as well to treat daytime response-fluctuations, if oral therapies fail to do so. Other options are injections with apomorphine to treat early morning dystonia and random off-periods during daytime, as well as continuously infused subcutaneous apomorphine for random fluctuations in PD patients...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27994352/assessment-of-fatigue-in-parkinson-s-disease-indian-perspective
#20
Birinder Singh Paul, Amandeep Singh, Dinesh Jain, Gagandeep Singh, Sandeep Kaushal, Gunchan Paul, Karan Kaura
CONTEXT: Fatigue is one of the most frequent nonmotor manifestations in Parkinson's disease (PD), having a major effect on quality of life but is not reported in Indian patients. AIMS: To evaluate the frequency of fatigue in a cohort of PD population and its correlation with disease. SETTINGS AND DESIGN: Fatigue Severity Scale (FSS) was translated and validated in local vernacular language. All patients of PD visiting neurology outpatient department of a tertiary care hospital...
October 2016: Annals of Indian Academy of Neurology
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