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Adenomatoid tumor

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https://www.readbyqxmd.com/read/27876138/adenomatoid-odontogenic-tumor-what-is-the-true-nature
#1
Arush Thakur, Jagdish Vishnu Tupkari, Tabita Joy, Amrut V Hanchate
The Adenomatoid odontogenic tumor (AOT) is one of the most controversial benign odontogenic tumor, which has been known to the pathologists for the past 100years. Since then the history, histogenesis and histopathologic designation of AOT remains a matter of debate. Some authors consider it as a true benign neoplasm while others consider it as a hamartoma and still others as an odontogenic cyst. Here we propose that the AOT should not be considered as a cyst because its true cystic nature remains questionable...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27857774/a-case-report-and-short-review-on-changing-trends-in-the-site-of-occurrence-of-adenomatoid-odontogenic-tumor-unravelling-the-past-15-years
#2
Sneha Sethi, Manish Kumar, Pratul Aggarwal, H S Indra Kumar, Chetan D Sugandhi, Silvie Singh
Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic lesion, with debatable histogenesis and variable histopathology. A systematic and diverse insight into the evolution, clinical presentation, histology, and immunohistochemical findings of this lesion is reviewed and presented. We reviewed the data published from 2000 to 2014 of approximately 255 cases that revealed a significant change in the incidence of predominant site involved, in contrast to the findings published by Reichart. We have also included the chronological order of events leading to the coining of the term AOT, which shows the curiosity that has been dedicated to understanding the lesion...
September 2016: Dental Research Journal
https://www.readbyqxmd.com/read/27817004/a-combined-epithelial-odontogenic-tumor-a-7-year-follow-up-case
#3
Ana Cláudia Garcia Rosa, Andresa Borges Soares, Cristiane Furuse, Sandro Régis Rodrigues Lima, Vera Cavalcanti de Araújo, Fabricio Passador-Santos
Adenomatoid odontogenic tumor (AOT) is a benign epithelial odontogenic tumor characterized by slow and progressive growth. When central lesions are associated with an unerupted permanent tooth, they are also known as the follicular type. Histological variants of AOT may complicate diagnosis with possible adverse effects on treatment and prognosis. The aim of this study is to report a case of a follicular AOT with extensive calcifying epithelial odontogenic tumor (CEOT)-like histopathological areas in the anterior region of the mandible that was treated by enucleation...
November 5, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27813512/genomic-profiling-of-malignant-peritoneal-mesothelioma-reveals-recurrent-alterations-in-epigenetic-regulatory-genes-bap1-setd2-and-ddx3x
#4
Nancy M Joseph, Yunn-Yi Chen, Anthony Nasr, Iwei Yeh, Eric Talevich, Courtney Onodera, Boris C Bastian, Joseph T Rabban, Karuna Garg, Charles Zaloudek, David A Solomon
Malignant mesothelioma is a rare cancer that arises from the mesothelial cells that line the pleural cavity and less commonly from the peritoneal lining of the abdomen and pelvis. Most pleural mesotheliomas arise in patients with a history of asbestos exposure, whereas the association of peritoneal mesotheliomas with exposure to asbestos and other potential carcinogens is less clear, suggesting that the genetic alterations that drive malignant peritoneal mesothelioma may be unique from those in pleural mesothelioma...
November 4, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27780042/immunoexpression-of-bmp-2-and-bmp-4-and-their-receptors-bmpr-ia-and-bmpr-ii-in-ameloblastomas-and-adenomatoid-odontogenic-tumors
#5
Marcelo Anderson Barbosa Nascimento, Cassiano Francisco Weege Nonaka, Carlos Augusto Galvão Barboza, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
OBJECTIVES: The present study evaluated the immunohistochemical expression of BMP-2 and BMP-4 and of their receptors (BMPR-IA and BMPR-II) in solid ameloblastoma (SA), unicystic ameloblastoma (UA) and adenomatoid odontogenic tumor (AOT) in order to obtain a better understanding of their role in the development and biological behavior of these tumors. DESIGN: This study analyzed these proteins in 30 cases of SA, 10 cases of UA, and 30 cases of AOT. Immunoexpression was evaluated in the parenchyma and stroma by attributing the following scores: 0, no stained cells; 1, ≤10%; 2, >10% and ≤25%; 3, >25% and ≤50%; 4, >50% and ≤75%...
October 19, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27770472/whatsapp-is-an-effective-tool-for-obtaining-second-opinion-in-oral-pathology-practice
#6
Sachin C Sarode, Gargi S Sarode, Rahul Anand, Shankargouda Patil, Hemant Unadkat
BACKGROUND: The aim of this study was to find out the efficacy of WhatsApp application for obtaining second opinion on histopathological diagnosis in oral pathology practice. METHODS: A total of 247 cases comprising of 34 different oral pathologies were photomicrographed using smartphone cameras through compound microscopes and sent for second opinion diagnosis (SOD) to 20 different oral pathologists using WhatsApp. RESULTS: Of 4795 (97.06%) total second opinion received, correct SOD were received for 4710 (98...
October 22, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27721599/expression-of-ck14-and-vimentin-in-adenomatoid-odontogenic-tumor-and-dentigerous-cyst
#7
Muniswamappa Sudhakara, S Puranik Rudrayya, Srineevas S Vanaki, RamanPreet Kaur Bhullar, M S Shivakumar, Mahadevi Hosur
BACKGROUND: Origin of adenomatoid odontogenic tumor (AOT) has long been a controversy, and the issue of it being a neoplasm or hamartoma was a subject of debate for a long time. Earlier it was grouped under a mixed group of odontogenic tumors considering the varying degrees of inductive changes. Recently, the WHO classification states that the presence of hard tissue within AOT was not due to induction but was rather a metaplastically produced mineralization and hence the tumor was reclassified under a group of tumors arising from odontogenic epithelium...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27672610/jaw-lesions-associated-with-impacted-tooth-a-radiographic-diagnostic-guide
#8
REVIEW
Hamed Mortazavi, Maryam Baharvand
This review article aimed to introduce a category of jaw lesions associated with impacted tooth. General search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks were used to find relevant studies using keywords such as "jaw lesion", "jaw disease", "impacted tooth", and "unerupted tooth". More than 250 articles were found, of which approximately 80 were broadly relevant to the topic. We ultimately included 47 articles that were closely related to the topic of interest...
September 2016: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/27647326/glypican-3-distinguishes-aggressive-from-non-aggressive-odontogenic-tumors-a-preliminary-study
#9
Ramon Barreto Mendes, Rosane Borges Dias, Andreia Leal Figueiredo, Clarissa Araújo Gurgel, Manoel Santana Filho, Leonardo Araújo Melo, Marília Trierveiler, Patrícia Ramos Cury, Rosalia Leonardi, Jean Nunes Dos Santos
BACKGROUND: Glypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors. METHODS: Fifty-nine cases of tumors were divided into aggressive odontogenic tumors (20 solid ameloblastomas, four unicystic ameloblastoma, 28 KOTs including five associated with Gorlin-Goltz syndrome) and non-aggressive odontogenic tumors (five adenomatoid odontogenic tumors and two calcifying cystic odontogenic tumors) and analyzed for glypican-3 using immunohistochemistry...
September 20, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27642441/a-retrospective-review-of-61-cases-of-adenomatoid-odontogenic-tumour-seen-in-five-tertiary-health-facilities-in-nigeria
#10
Akinyele Olumuyiwa Adisa, Ahmed Oluwatoyin Lawal, Olajumoke Ajibola Effiom, Olujide Oladele Soyele, Olufemi Gbenga Omitola, Adetokunbo Olawuyi, Benjamin Fomete
INTRODUCTION: Adenomatoid odontogenic tumor (AOT) is a benign lesion originating from the dental lamina or its remnants. It is a relatively uncommon neoplasm representing about 3% of all odontogenic tumors. The aim of this study was to examine the clinical and radiological characteristics of AOTs in five major tertiary centres in Nigeria. METHODS: Archival hospital-based data stores of five tertiary health facilities in Nigeria were accessed. Case files and biopsy records were retrieved to obtain relevant information...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27631338/morphological-immunohistochemical-and-chromosomal-analysis-of-multicystic-chromophobe-renal-cell-carcinoma-an-architecturally-unusual-challenging-variant
#11
Maria Pané Foix, Ana Dunatov, Petr Martinek, Enric Condom Mundó, Saul Suster, Maris Sperga, Jose I Lopez, Monika Ulamec, Stela Bulimbasic, Delia Perez Montiel, Reza Alaghehbandan, Kvetoslava Peckova, Krystina Pivovarcikova, Daum Ondrej, Pavla Rotterova, Faruk Skenderi, Kristyna Prochazkova, Martin Dusek, Milan Hora, Michal Michal, Ondrej Hes
Chromophobe renal cell carcinoma (ChRCC) is typically composed of large leaf-like cells and smaller eosinophilic cells arranged in a solid-alveolar pattern. Eosinophilic, adenomatoid/pigmented, or neuroendocrine variants have also been described. We collected 10 cases of ChRCC with a distinct multicystic pattern out of 733 ChRCCs from our registry, and subsequently analyzed these by morphology, immunohistochemistry, and array comparative genomic hybridization. Of the 10 patients, 6 were males with an age range of 50-89 years (mean 68, median 69)...
December 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27627864/immunohistochemical-analysis-of-myofibroblasts-tgf-%C3%AE-1-and-ifn-%C3%AE-in-epithelial-odontogenic-lesions
#12
Pedro Paulo de Andrade Santos, Cassiano Francisco Weege Nonaka, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
AIM: To investigate the presence of myofibroblasts (MFBs) in epithelial odontogenic lesions by immunohistochemistry and to correlate the findings with tumor aggressiveness, as well as to analyze the expression of TGF-β1 and IFN-γ during the differentiation of these cells. METHODS AND RESULTS: Twenty solid ameloblastomas (SAs), 10 unicystic ameloblastomas (UAs), 20 keratocystic odontogenic tumors (KCOTs), and 20 adenomatoid odontogenic tumors (AOTs) were selected...
September 15, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27601817/kallikrein-4-and-matrix-metalloproteinase-20-immunoexpression-in-malignant-benign-and-infiltrative-odontogenic-tumors
#13
Marcelo Macedo Crivelini, Denise Tostes Oliveira, Ricardo Alves de Mesquita, Suzana Cantanhede Orsini Machado de Sousa, Adriano Motta Loyola
CONTEXT: Matrix metalloproteinase-20 (MMP20) (enamelysin) and kallikrein 4 (KLK4) are enzymes secreted by ameloblasts that play an important role in enamel matrix degradation during amelogenesis. However, studies have shown that neoplastic cells can produce such enzymes, which may affect the tumor infiltrative and metastatic behaviors. AIMS: The aim of this study is to assess the biological role of MMP20 and KLK4 in odontogenic tumors. MATERIALS AND METHODS: The enzymes were analyzed immunohistochemically in ameloblastoma, adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor, keratocystic odontogenic tumor with or without recurrence and odontogenic carcinoma...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27601807/odontogenic-tumors-in-port-harcourt-south-south-geopolitical-zone-of-nigeria
#14
C A Iyogun, O G Omitola, G E Ukegheson
AIM: A retrospective study of odontogenic tumors (OTs) in Port Harcourt was undertaken to establish its prevalence and compare with known data in the literature from Nigeria and elsewhere. MATERIALS AND METHODS: All pathologically diagnosed OTs between 2008 and 2013 at the archives of the Department of Oral Pathology and Oral Biology of the University of Port Harcourt/University of Port Harcourt Teaching Hospital were retrospectively studied and classified according to the 2005 WHO classification of OTs and allied diseases...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27556063/renal-transplantation-related-risk-factors-for-the-development-of-uterine-adenomatoid-tumors
#15
Teruyuki Mizutani, Osamu Yamamuro, Noriko Kato, Kazumasa Hayashi, Junya Chaya, Norihiko Goto, Toyonori Tsuzuki
•We analyzed the epidemiological factors for clinical manifestations of uterine adenomatoid tumors.•Renal transplantation with immunosuppression therapy is risk factor for the development of uterine adenomatoid tumors.•The length of time on dialysis is risk factor for the development of uterine adenomatoid tumors.
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27541702/immunoprofile-of-the-adenomatoid-odontogenic-tumour
#16
Peter A Reichart, Hans Peter Philipsen, Pathawee Khongkhunthian, James J Sciubba
The present study was focused on the immunohistochemical profile of the adenomatoid odontogenic tumor. A Pub/Medline search revealed a number of immunohistochemical studies including cytokeratin profiles, extracellular matrix proteins, Integrins, ameloblast-associated proteins resorption regulators (RANK, RANKL), p53, PCNA, MDM2 protein, cyclin D1, Ki-67, Bcl-2 metallothionein, metalloproteinases, D56 hepatocyte growth factor, c-met, DNA methyltransferase, podoplanin, TGF-βI, Smad-2/3, Smad-I-5/-8, Smad 4, beta- catenin, calretinin and clonality...
August 19, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27539290/comparison-of-the-classical-method-and-see-fim-protocol-in-detecting-microscopic-lesions-in-fallopian-tubes-with-gynecological-lesions
#17
Nermin Koc, Selçuk Ayas, Sevcan Arzu Arinkan
Background: The objective of this study was to compare the classical method and Sectioning and Extensively Examining the Fimbriated End Protocol (SEE-FIM) in detecting microscopic lesions in fallopian tubes with gynecological lesions. Materials and Methods: From a total of 1,118 cases, 582 with various parts of both fallopian tubes sampled in three-ring-shape sections and 536 sampled with the SEE-FIM protocol were included in this study. Pathological findings of cases with endometrial carcinoma, non-uterine pelvic malignant tumor, ovarian borderline tumors, premalignancy, and benign lesions were compared...
August 19, 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27499595/clinical-radiological-and-histopathological-analysis-of-paraovarian-cysts
#18
Avantika Gupta, Purnima Gupta, Usha Manaktala, Nita Khurana
INTRODUCTION: Paraovarian cyst arise from either mesothelium or from paramesonephric remnant. These present as either adneal mass or as an incidental finding. Diagnosis is usually established on ultrasound and it is important to differentiate these from ovarian cyst. MATERIAL AND METHODS: The present study is a retrospective analysis of 32 women with a confirmed diagnosis of paraovarian cyst after surgery. The clinical profile, symptoms and radiological findings of these patients were noted from the hospital records...
April 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27461816/an-adenomatoid-odontogenic-tumor-in-disguise
#19
Rajesh B Dhirawani, Sanyog Pathak, K Mallikaarjuna, Ankit Sharma
Adenomatoid odontogenic tumor (AOT) is a slowly growing benign tumor of the oral cavity. It accounts of 3-7% of all odontogenic tumors. It is seen to occur commonly in the anterior maxilla. The tumor is usually associated with an impacted tooth with maxillary canine being the most common tooth. AOT is seen in a younger group, especially below 20 years with a female preponderance. AOT occurs in two main variants: Central or intraosseous which is more common and second is peripheral which is rare. Radiologically, it represents as a radiolucent lesion with radiopaque foci usually an impacted or a supernumerary tooth...
July 2016: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/27456590/respiratory-epithelial-adenomatoid-hamartomas-an-increasingly-common-diagnosis-in-the-setting-of-nasal-polyps
#20
Wesley L Davison, Aaron N Pearlman, Luke A Donatelli, Lindsey M Conley
BACKGROUND: Respiratory epithelial adenomatoid hamartomas (REAH) are benign nose neoplasms found in the nasal cavity and sinuses. Symptoms include anosmia, nasal obstruction, facial pressure, and rhinorrhea. Although previously thought to be rare, these tumors are being increasingly recognized on pathology in patients undergoing endoscopic sinus surgery. However, REAH is difficult to diagnose before surgery because it may mimic other entities, such as nasal polyps or inverted papilloma, and is often found incidentally only after surgery...
July 2016: American Journal of Rhinology & Allergy
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