F Gaytan, C Morales, M L Barreiro, P Jeffery, L K Chopin, A C Herington, F F Casanueva, E Aguilar, C Dieguez, M Tena-Sempere
Ghrelin, the endogenous ligand of the GH secretagogue receptor (GHS-R), is a newly identified, ubiquitously expressed molecule that has been involved in a wide array of endocrine and nonendocrine functions, including cell proliferation. In this context, our group recently reported the expression of ghrelin and its functional receptor, the GHS-R type 1a, in the human ovary and testis as well as several testicular tumors. Ovarian malignancies, however, remain unexplored. Notably, a vast majority of ovarian tumors derive from the surface epithelium, which originates from the celomic epithelium...
March 2005: Journal of Clinical Endocrinology and Metabolism