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Swapnil Parve, Ali Ershadi, Alexandr Karimov, Anne Dougherty, Chiratidzo E Ndhlovu, Midion M Chidzonga, Majid Sadigh
BACKGROUND: The Medical Education Partnership Initiative, has helped to mitigate the digital divide in Africa. The aim of the study was to assess the level of access, attitude, and training concerning meaningful use of electronic resources and EBM among medical students at an African medical school. METHODS: The study involved medical students at the University of Zimbabwe College of Health Sciences, Harare. The needs assessment tool consisted of a 21-question, paper-based, voluntary and anonymous survey...
September 2016: African Health Sciences
Xiao Ye
A discussion on "Is traditional Chinese medicine (TCM) really relevant?" was held in the University College London (UCL) on the afternoon of 31st March, 2015. The author summarized some core viewpoints of the participants and then tried to focus on the opponent's opinions to clear up the arguments by illustrating respects of history, knowledge learning process, evidence based medicine (EBM) and strengths of TCM. This article will propose that the human health is extremely delicate and complicated and that no system of medicine can resolve all the problems of the human body...
December 2016: Complementary Therapies in Medicine
Samantha Cassar, Marie L Misso, William G Hopkins, Christopher S Shaw, Helena J Teede, Nigel K Stepto
STUDY QUESTION: What is the degree of intrinsic insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and the relative contribution of BMI to overall IR based on meta-analysis of gold standard insulin clamp studies? SUMMARY ANSWER: We report an inherent reduction (-27%) of insulin sensitivity (IS) in PCOS patients, which was independent of BMI. WHAT IS ALREADY KNOWN: PCOS is prevalent, complex and underpinned by IR but controversies surround the degree of intrinsic IR in PCOS, the effect of BMI and the impact of the different diagnostic criteria (NIH versus Rotterdam) in PCOS...
November 2016: Human Reproduction
Magdalena Koperny, Wiktoria Leśniak, Miłosz Jankowski, Małgorzata Bała
Evidence-based medicine (EBM) is an approach to decision making on the basis of the reliable and up to date best evidence. EBM is regarded as the gold standard all over the world. Cochrane Collaboration is one of the institutions, which promote EBM among physicians, policy makers and other health care workers. Cochrane Collaboration is international non-profit organization bringing together people from all over the world, the aim of which is to create and disseminate reliable scientific information. The Cochrane Collaboration develops and publishes systematic reviews on medical and diagnostic procedures...
2016: Przegla̧d Epidemiologiczny
Charlotte Kelly, Claire Hulme, Tracey Farragher, Graham Clarke
OBJECTIVES: To investigate whether there is an association between differences in travel time/travel distance to healthcare services and patients' health outcomes and assimilate the methodologies used to measure this. DESIGN: Systematic Review. We searched MEDLINE, Embase, Web of Science, Transport database, HMIC and EBM Reviews for studies up to 7 September 2016. Studies were excluded that included children (including maternity), emergency medical travel or countries classed as being in the global south...
November 24, 2016: BMJ Open
Xiao-Ang Li, Yuen-Shan Ho, Lei Chen, W L Wendy Hsiao
Icariin, an ingredient in the medicinal herb Epimedium brevicornum Maxim (EbM), has been considered as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's disease (AD). Hyperhomocysteinaemia is a risk factor for AD and other associated neurological diseases. In this study we aim to investigate whether icariin can reverse homocysteine (Hcy)-induced neurotoxicity in primary embryonic cultures of rat cortical neurons. Our findings demonstrated that icariin might be able restore the cytoskeleton network damaged by Hcy through the modulation of acetyl-α-tubulin, tyrosinated-α-tubulin, and phosphorylation of the tubulin-binding protein Tau...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Matteo Capobussi, Rita Banzi, Lorenzo Moja, Stefanos Bonovas, Marien González-Lorenzo, Elisa Giulia Liberati, Hernan Polo Friz, Oriana Nanni, Massimo Mangia, Francesca Ruggiero
INTRODUCTION: One of the aims of Evidence-Based Medicine is to improve quality and appropriateness of care by the expedition of the knowledge transfer process. Computerized Decision Support Systems (CDSSs) are computer programs that provide alerts to the prescribing doctor directly at the moment of medical examination. In fact, alerts are integrated within the single patient electronic health record. CDSS based on the best available and updated evidence and guidelines may be an efficient tool to facilitate the transfer of the latest results from clinical research directly at the bedside, thus supporting decision-making...
November 2016: Recenti Progressi in Medicina
(no author information available yet)
The purpose of this paper is to report the updating process of the CCAFU evidence-based Clinical Practice Guideline (CPG), on urinary and genital tracts management, which was edited in 2013. Updating of CPG is a continuous process based on systematic search of the scientific literature aiming to identify clinical questions to be updated. The CPGs were defined following the RPC methodology based on evidence synthesis and explicit and transparent experts'opinion and on the ADAPTE methodology when good quality guidelines were available...
November 2016: Progrès en Urologie
Barry Robson
The Q-UEL language of XML-like tags and the associated software applications are providing a valuable toolkit for Evidence Based Medicine (EBM). In this paper the already existing applications, data bases, and tags are brought together with new ones. The particular Q-UEL embodiment used here is the BioIngine. The main challenge is one of bringing together the methods of symbolic reasoning and calculative probabilistic inference that underlie EBM and medical decision making. Some space is taken to review this background...
October 17, 2016: Computers in Biology and Medicine
Rebecca M Rentea, Amy J Wagner, David M Gourlay, Melissa Christensen, Jennifer L Liedel
BACKGROUND: Maternal stress on neonatal outcomes of infants admitted to the NICU is incompletely understood. We previously demonstrated breast milk derived cytokines remain biologically active in the neonatal intestine. We hypothesized that the need for neonatal surgical intervention would be stimulus leading to maternal cytokine production thus affecting neonatal outcome. METHODS: Discarded expressed breast milk (EBM) in the first 3weeks following delivery was analyzed for IL-23 and IL-10 by ELISA...
October 27, 2016: Journal of Pediatric Surgery
Morhaf Al Achkar, M Kelly Davies
BACKGROUND: Evidence-based medicine (EBM) skills are invaluable tools for residents and practicing physicians. The purpose of this study is to evaluate the effectiveness of small-group learning models in teaching fundamental EBM skills. METHODS: The intervention consisted of an EBM bootcamp divided into four 2-hour sessions across 4-week rotations. Residents worked in small groups of three to four to explore fundamentals of EBM through interactive dialogue and mock clinical scenario practice...
2016: Advances in Medical Education and Practice
António Vaz Carneiro
Clinicians are used to treat individual patients, and therefore may feel that clinical trials and systematic reviews do not give information for optimal treatment of the single patient.Evidence Based Medicine (EBM) is the integration of research evidence (from clinically relevant studies conducted using sound methodology) with clinical expertise (clinician's cumulated experience) and patient values (personal preferences and unique concerns and expectations).The practical steps of EBM include: 1) assess the patient, 2) ask the clinical question, 3) acquire the evidence, 4) critically appraise the evidence, 5) apply the results to the patient and 6) self-evaluate one's practice...
November 4, 2016: Clinical Hemorheology and Microcirculation
Reeta Bora, Nishchay B Murthy
OBJECTIVE: To evaluate feasibility of complete enteral feed in stable very low birth weight neonates weighing 1000-1500 gms. SUBJECTS AND INTERVENTIONS: One hundred & three stable vlbw neonates (1000-1500gms) irrespective of gestational age were randomized to receive either complete enteral feed(CEF) with expressed breast milk (EBM)(n = 51) or minimal enteral feed (MEF) supplemented with intravenous fluid. (MEF)(n = 52).Feed volume was increased progressively...
November 3, 2016: Journal of Maternal-fetal & Neonatal Medicine
H Wang, B J Zhao, R Z Yan, C Wang, C C Luo, M Hu
Objective: To investigate the biocompatibility of Ti-6Al-4V scaffolds fabricated by electron beam melting(EBM). Methods: Bone marrow mesenchymal stem cells(BMSC) co-cultured with Ti-6Al-4V specimens fabricated with EBM was prepared as experimental group and the regular cells culture was employed as control. The biocompatibility was detected using CCK-8 and cytoskeleton staining. The osteogenic differentiation ability was assessed using mineralization nodule formation. A 24 mm defect was created on the right mandibular body in 12 beagles...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
R Z Yan, Y F Li, C Wang, R X Li, Z W Liu, M Hu
Objective: To examine the biomechanical properties of three-dimensional(3D) printed electron beam melting(EBM) Ti-6Al-4V mesh as scaffold for mandibular repairment. Methods: We fabricated Ti-6Al-4V samples of different structures with strut, sheet and 3D mesh scaffolds(a controllable diameter 0.35, 0.50, 0.70 mm, distribution density: intensive sparse) by EBM process. The mechanical properties of these structures were examined by X-ray energy dispersive spectrum(EDS), uniaxial tensile test, three-point bending test, under compression load and compared with their different microstructure and mechanical properties...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
Xiwen Qin, Tiew-Hwa Katherine Teng, Joseph Hung, Tom Briffa, Frank M Sanfilippo
INTRODUCTION: Heart failure (HF) is a chronic, debilitating and progressive disease associated with high morbidity and mortality. Evidence-based medications (EBMs) are the cornerstone of management of patients with HF. In Australia, these EBMs are subsidised by the Commonwealth Government under the Pharmaceutical Benefits Scheme. Suboptimal dispensing and non-adherence to these EBMs have been observed in patients with HF. Our study will investigate trends in dispensing patterns, as well as adherence and persistence of EBMs for HF...
November 1, 2016: BMJ Open
Shivani Dogra, Anup Thakur, Pankaj Garg, Neelam Kler
OBJECTIVE: To determine if higher enteral protein intake leads to improved head growth at 40 weeks postmenstrual age (PMA) in preterm infants less than 32 weeks or 1500 g. METHOD: Randomized controlled trial in which 120 infants were assigned to either group A with higher enteral protein intake achieved by fortification with higher protein containing fortifier [1 g/100 ml expressed breast milk (EBM)] or to group B with lower enteral protein intake where fortification was done with standard available protein fortifier (0...
October 31, 2016: Journal of Pediatric Gastroenterology and Nutrition
Lauren A Maggio
INTRODUCTION: Evidence-based medicine (EBM) is an expectation of professional healthcare and a requisite component of medical school curricula. However, upon graduation medical students' EBM skills have been found lacking suggesting a need to examine EBM training. METHODS: This PhD report presents two studies on EBM education. The first study is a literature review that describes and attempts to assess educational interventions for teaching medical students EBM...
December 2016: Perspectives on Medical Education
Yuriko Doi
 Evidence-based medicine (EBM) is fundamental to ensuring high-quality medical care. It requires systematic reviews and meta-analyses to synthesize diverse information available from individual clinical studies. However, the literature reviewed may represent an incomplete and selective set of research findings, which could lead to publication/reporting biases and distort the true picture of research as a whole. Prospective registry of all clinical trials in the world is mandatory to reduce the biases, which have been disclosed on the International Clinical Trials Registry Platform (ICTRP) of the World Health Organization (WHO) since 2007...
2016: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
Bingjing Zhao, Hong Wang, Ning Qiao, Chao Wang, Min Hu
The purpose of this study is to determine the corrosion resistance of Ti-6Al-4V alloy fabricated with electron beam melting and selective laser melting for implantation in vivo. Ti-6Al-4V alloy specimens were fabricated with electron beam melting (EBM) and selective laser melting (SLM). A wrought form of Ti-6Al-4V alloy was used as a control. Surface morphology observation, component analysis, corrosion resistance experimental results, electrochemical impedance spectroscopy, crevice corrosion resistance experimental results, immersion test and metal ions precipitation analysis were processed, respectively...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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