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https://www.readbyqxmd.com/read/28526630/what-is-the-impact-of-bariatric-surgery-on-erectile-function-a%C3%A2-systematic-review-and-meta-analysis
#1
REVIEW
Felipe Placco Araujo Glina, Júlia Walter de Freitas Barboza, Victor Moises Nunes, Sidney Glina, Wanderley Marques Bernardo
INTRODUCTION: Obesity is a worldwide public health issue that has severe psychological and social implications. Erectile dysfunction also is a prevalent clinical situation, and obesity is one of the primary risk factors for its development. AIM: To determine whether bariatric surgery can lessen erectile dysfunction in obese men because of evidence showing that weight loss in obese men contributes to decreasing erectile dysfunction and bariatric surgery contributes to significant weight loss...
May 16, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28526062/polypharmacy-in-multimorbid-older-adults-protocol-for-a-systematic-review
#2
Caroline Sirois, Marie-Laure Laroche, Line Guénette, Edeltraut Kröger, Dan Cooper, Valérie Émond
BACKGROUND: Polypharmacy, the concurrent use of multiple medications, consistently evokes a negative connotation, notably because it is associated with a plethora of adverse events. Nonetheless, the number of individuals exposed to polypharmacy is increasing steeply, especially for older people with multiple diseases. There is a need to carefully study the phenomenon at the population scale to full assess the associated health outcomes. Yet, this reveals a complex task because there exists no consensus indicator of polypharmacy...
May 19, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28521883/treatment-with-high-dose-salicylates-improves-cardiometabolic-parameters-meta-analysis-of-randomized-controlled-trials
#3
Estifanos Baye, Negar Naderpoor, Marie Misso, Helena Teede, Lisa J Moran, Barbora de Courten
INTRODUCTION: There is conflicting evidence regarding the efficacy of high dose salicylates in improving cardiometabolic risk in healthy and type 2 diabetes patients. We aimed to determine whether treatment with salicylates at an anti-inflammatory dose (≥1g daily) would improve cardiometabolic risk in healthy individuals and type 2 diabetes patients, compared to placebo. METHODS: Medline, Medline-in-process, Embase, and all EBM databases were searched for studies published up to December 2016...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28508440/has-evidence-based-medicine-ever-been-modern-a-latour-inspired-understanding-of-a-changing-ebm
#4
Sietse Wieringa, Eivind Engebretsen, Kristin Heggen, Trish Greenhalgh
Evidence-based health care (EBHC), previously evidence-based medicine (EBM), is considered by many to have modernized health care and brought it from an authority-based past to a more rationalist, scientific grounding. But recent concerns and criticisms pose serious challenges and urge us to look at the fundamentals of a changing EBHC. In this paper, we present French philosopher Bruno Latour's vision on modernity as a framework to discuss current changes in the discourse on EBHC/EBM. Drawing on Latour's work, we argue that the early EBM movement had a strong modernist agenda with an aim to "purify" clinical reality into a dichotomy of objective "evidence" from nature and subjective "preferences" from human society and culture...
May 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28506643/epithelial-basement-membrane-injury-and-regeneration-modulates-corneal-fibrosis-after-pseudomonas-corneal-ulcers-in-rabbits
#5
Gustavo K Marino, Marcony R Santhiago, Santhanam Abirami, Luciana L Dibbin, Thangavadivel Shanmugapriya, Carla S Medeiros, Karthikeyan Bose, Kwai Ping Tam, Steven E Wilson
The purpose of this study was to investigate whether myofibroblast-related fibrosis (scarring) after microbial keratitis was modulated by the epithelial basement membrane (EBM) injury and regeneration. Rabbits were infected with Pseudomonas aeruginosa after epithelial scrape injury and the resultant severe keratitis was treated with topical tobramycin. Corneas were analyzed from one to four months after keratitis with slit lamp photos, immunohistochemistry for alpha-smooth muscle actin (α-SMA) and monocyte lineage marker CD11b, and transmission electron microscopy...
May 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28499402/erk-signaling-is-required-for-vegf-a-vegfr2-induced-differentiation-of-porcine-adipose-derived-mesenchymal-stem-cells-into-endothelial-cells
#6
Sami G Almalki, Devendra K Agrawal
BACKGROUND: Cell-based therapy that can rejuvenate the endothelium with stimulated adipose-derived mesenchymal stem cells (AMSCs) is a promising therapeutic strategy for the re-endothelialization of denuded arteries at the stenting site. Previously, we have shown that silencing of MMP-2 and MMP-14 inhibits vascular endothelial growth factor receptor type 2 (VEGFR2) cleavage, and induces differentiation of AMSCs toward the endothelial cell (EC) lineage. In this study, we examined the underlying signaling pathways that regulate differentiation of AMSCs to ECs in vitro through VEGFR2...
May 12, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28494040/micro-to-macroroughness-of-additively-manufactured-titanium-implants-in-terms-of-coagulation-and-contact-activation
#7
Rebecca Klingvall Ek, Jaan Hong, Andreas Thor, Mikael Bäckström, Lars-Erik Rännar
PURPOSE: This study aimed to evaluate how as-built electron beam melting (EBM) surface properties affect the onset of blood coagulation. The properties of EBM-manufactured implant surfaces for placement have, until now, remained largely unexplored in literature. Implants with conventional designs and custom-made implants have been manufactured using EBM technology and later placed into the human body. Many of the conventional implants used today, such as dental implants, display modified surfaces to optimize bone ingrowth, whereas custom-made implants, by and large, have machined surfaces...
May 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28486725/regeneration-of-defective-epithelial-basement-membrane-and-restoration-of-corneal-transparency-after-photorefractive-keratectomy
#8
Gustavo K Marino, Marcony R Santhiago, Abirami Santhanam, Andre A M Torricelli, Steven E Wilson
PURPOSE: To study regeneration of the normal ultrastructure of the epithelial basement membrane (EBM) in rabbit corneas that had -9.00 D photorefractive keratectomy (PRK) and developed late haze (fibrosis) with restoration of transparency over 1 to 4 months after surgery and in corneas that had incisional wounds. METHODS: Twenty-four rabbits had one of their eyes included in one of the two procedure groups (-9.00 D PRK or nearly full-thickness incisional wounds), whereas the opposite eyes served as the unwounded control group...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28486363/effects-of-exercise-on-mild-to-moderate-depressive-symptoms-in-the-postpartum-period-a-meta-analysis
#9
Ashley P McCurdy, Normand G Boulé, Allison Sivak, Margie H Davenport
OBJECTIVE: To examine the influence of exercise on depressive symptoms and the prevalence of depression in the postpartum period. DATA SOURCES: A structured search of MEDLINE, EMBASE, CINAHL, Sport Discus, Ovid's All EBM Reviews, and ClinicalTrials.gov databases was performed with dates from the beginning of the databases until June 16, 2016. The search combined keywords and MeSH-like terms including, but not limited to, "exercise," "postpartum," "depression," and "randomized controlled trial...
May 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28476382/ebm-versus-bissm-because-i-said-so-medicine
#10
EDITORIAL
Daniel C Jupiter, Naohiro Shibuya
No abstract text is available yet for this article.
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28475423/investigating-the-abscopal-effects-of-radioablation-on-shielded-bone-marrow-in-rodent-models-using-multimodality-imaging
#11
Solmaz F Afshar, Janice A Zawaski, Taeko Inoue, David A Rendon, Arthur W Zieske, Jyotinder N Punia, Omaima M Sabek, M Waleed Gaber
The abscopal effect is the response to radiation at sites that are distant from the irradiated site of an organism, and it is thought to play a role in bone marrow (BM) recovery by initiating responses in the unirradiated bone marrow. Understanding the mechanism of this effect has applications in treating BM failure (BMF) and BM transplantation (BMT), and improving survival of nuclear disaster victims. Here, we investigated the use of multimodality imaging as a translational tool to longitudinally assess bone marrow recovery...
May 5, 2017: Radiation Research
https://www.readbyqxmd.com/read/28472986/multiple-strategy-peer-taught-evidence-based-medicine-course-in-a-poor-resource-setting
#12
Ammar Sabouni, Yamama Bdaiwi, Saad L Janoudi, Lubaba O Namous, Tarek Turk, Mahmoud Alkhatib, Fatima Abbas, Ruba Zuhri Yafi
BACKGROUND: Teaching Evidence Based Medicine (EBM) is becoming a priority in the healthcare process. For undergraduates, it has been proved that integrating multiple strategies in teaching EBM yields better results than a single, short-duration strategy. However, there is a lack of evidence on applying EBM educational interventions in developing countries. In this study, we aim to evaluate the effectiveness of a multiple strategy peer-taught online course in improving EBM awareness and skills among medical students in two developing countries, Syria and Egypt...
May 4, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28468646/a-real-world-approach-to-evidence-based-medicine-in-general-practice-a-competency-framework-derived-from-a-systematic-review-and-delphi-process
#13
Kevin Galbraith, Alison Ward, Carl Heneghan
BACKGROUND: Evidence-Based Medicine (EBM) skills have been included in general practice curricula and competency frameworks. However, GPs experience numerous barriers to developing and maintaining EBM skills, and some GPs feel the EBM movement misunderstands, and threatens their traditional role. We therefore need a new approach that acknowledges the constraints encountered in real-world general practice. The aim of this study was to synthesise from empirical research a real-world EBM competency framework for general practice, which could be applied in training, in the individual pursuit of continuing professional development, and in routine care...
May 3, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28459048/hiv-point-of-care-testing-in-canadian-settings-a-scoping-review
#14
REVIEW
Alexa Minichiello, Michelle Swab, Meck Chongo, Zack Marshall, Jacqueline Gahagan, Allison Maybank, Aurélie Hot, Michael Schwandt, Sonia Gaudry, Oliver Hurley, Shabnam Asghari
BACKGROUND: HIV point-of-care testing (POCT) was approved for use in Canada in 2005 and provides important public health benefits by providing rapid screening results rather than sending a blood sample to a laboratory and waiting on test results. Access to test results soon after testing (or during the same visit) is believed to increase the likelihood that individuals will receive their results and improve access to confirmatory testing and linkages to care. This paper reviews the literature on the utilization of HIV POCT across Canadian provinces...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28452179/the-effect-of-an-evidence-based-medicine-course-on-medical-student-critical-thinking
#15
Jing Wang, Danhua Wang, Yanling Chen, Qin Zhou, Hong Xie, Jin Chen, Youping Li
OBJECTIVE: Evidence-based medicine (EBM) was designed to foster student Critical Thinking (CT) while conveying knowledge to them. Chinese medical schools have adopted EBM to a varying degree but studies to examine its intended effect are few. This study evaluates the effect of an EBM course on Chinese medical student CT. METHODS: A total of 158 medical students at a Chinese medical school took a seven-category Chinese version of the Critical Thinking Disposition Inventory (CTDI-CV) before and after taking an EBM course...
April 27, 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28436377/analysis-of-therapeutic-effectiveness-of-selected-types-of-collagen-in-prevention-and-treatment-of-degenerative-joint-disease
#16
Wiesław Tomaszewski, Anna Paradowska
Loss of collagen is a natural development accompanying aging of the body. It may be additionally accelerated by various conditions, including osteoarthritis (OA). Within the last two decades numerous and diverse studies have been conducted worldwide with the aim of identifying substances containing collagen, producing therapeutic preparations of expected effectiveness in the prevention and therapy of OA that would be safe to use and developing methods of delivering the final product into the body. The authors reviewed and analysed the latest available literature by selecting papers presenting the findings of studies conducted in line with the principles of Evidence-Based Medicine (EBM)...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28417080/applying-a-systems-approach-to-thyroid-physiology-looking-at-the-whole-with-a-mitochondrial-perspective-instead-of-judging-single-tsh-values-or-why-we-should-know-more-about-mitochondria-to-understand-metabolism
#17
REVIEW
Roy Moncayo, Helga Moncayo
Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. In this paper we want to challenge this model of limited application by proposing a construct based on a systems approach departing from two basic considerations. In first place since the majority of cases of thyroid disease develop and appear during life it has to be considered as an acquired condition...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28402864/meta-analysis-on-anticoagulation-and-prevention-of-thrombosis-and-mortality-among-patients-with-lung-cancer
#18
H E Fuentes, D M Oramas, L H Paz, A I Casanegra, A S Mansfield, A J Tafur
BACKGROUND: Venous thromboembolism (Wickham et al., 2012 [1]) is a leading cause of morbidity and mortality among patients with cancer; however, primary thromboprophylaxis is not routinely recommended. We performed a systematic review and meta-analysis of randomized control trials (RCTs) to measure the impact of primary VTE prevention and its effect on mortality among patients with lung cancer. METHODS: With assistance from a master librarian, we searched Ovid, Scopus, DARE, CINAHL, MEDLINE, EMBASE, EBM reviews-Cochrane database of systematic reviews, EBM reviews-ACP journal, and EBM Reviews-Databases for relevant studies following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
April 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28400357/health-care-professionals-evidence-based-medicine-internet-searches-closely-mimic-the-known-seasonal-variation-of-lyme-borreliosis-a-register-based-study
#19
Samuli Pesälä, Mikko J Virtanen, Jussi Sane, Jukkapekka Jousimaa, Outi Lyytikäinen, Satu Murtopuro, Pekka Mustonen, Minna Kaila, Otto Helve
BACKGROUND: Both health care professionals and nonprofessionals seek medical information on the Internet. Using Web-based search engine searches to detect epidemic diseases has, however, been problematic. Physician's databases (PD) is a chargeable evidence-based medicine (EBM) portal on the Internet for health care professionals and is available throughout the entire health care system in Finland. Lyme borreliosis (LB), a well-defined disease model, shows temporal and regional variation in Finland...
April 11, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28398910/ebm-vs-ebm-combining-evidence-based-and-experienced-based-medicine-in-resuscitation-research
#20
Paul E Pepe, Tom P Aufderheide
PURPOSE OF REVIEW: To discuss the clear rationale for evidence-based medicine (EvBM) in the challenging realms of resuscitation research, yet also provide case examples in which even the well designed, multicentered randomized clinical trial may have had unrecognized limitations, and thus misleading results. This is where experienced-based medicine (ExBM) helps to resolve the issue. RECENT FINDINGS: Recent publications have brought to task the conclusions drawn from various clinical trials of resuscitative interventions...
June 2017: Current Opinion in Critical Care
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