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arrhythmias and hyperuricemia

Alena Skrahina, Hennadz Hurevich, Dennis Falzon, Liudmila Zhilevich, Valiantsin Rusovich, Masoud Dara, Svetlana Setkina
BACKGROUND/OBJECTIVE: Outcomes of treatment for multidrug-resistant tuberculosis (MDR-TB) remain poor worldwide. Among patients with MDR-TB in Belarus who started treatment in 2012, only 54% completed it successfully, with treatment failure reported in 22% of the patients; additionally, 11% died and 13% were lost to follow-up or remained unevaluated. In Belarus, to improve outcomes, bedaquiline was introduced in MDR-TB treatment in June 2015. The national TB program developed measures to monitor safety and effectiveness of bedaquiline-containing regimens in line with the World Health Organization recommendations...
December 2016: International Journal of Mycobacteriology
Tsung-Ming Lee, Shinn-Zong Lin, Nen-Chung Chang
Hyperuricemia has been shown to be associated with ventricular arrhythmias. However, the mechanisms remained unknown. We assessed whether different urate-lowering agents can attenuate arrhythmias through lowering urate itself or inhibiting xanthenes oxidize (XO) activity in infarcted rats. Male Wistar rats after ligating coronary artery were randomized to either allopurinol, or febuxostat, chemically unrelated inhibitors of XO, benzbromarone or vehicle for 4 weeks. Post-infarction was associated with increased oxidant stress, as measured by myocardial superoxide, isoprostane, XO activity and dihydroethidine fluorescence staining...
May 2016: Journal of Pharmacological Sciences
Jennifer Dinnel, Bonny L Moore, Brent M Skiver, Prithviraj Bose
Tumor lysis syndrome (TLS) is a potentially life-threatening complication of cancer therapy characterized by two or more of the following laboratory abnormalities: hyperuricemia, hyperkalemia, hypocalcemia, and hyperphosphatemia, with resultant end-organ damage, eg, renal failure, seizures, or cardiac arrhythmias. High-risk patients include those with highly proliferative cancers and/or large tumor burdens, particularly in the setting of highly effective chemotherapy, among other risk factors. Before 2002, antihyperuricemic drug therapy was limited to allopurinol, a xanthine oxidase inhibitor...
2015: Core Evidence
Asiye Kanbay, Handan Inonu, Yalcin Solak, Abdulsamet Erden, Emine Uslu, Sevgi Arik Yuksel, Mehmet Akif Ozturk, Kim McFann, Richard J Johnson, Mehmet Kanbay
BACKGROUND AND AIMS: Obstructive sleep apnea (OSA) is now considered as an independent risk factor for cardiovascular (CV) disease. Although uric acid is increasingly being implicated in CV morbidity and mortality, no study attempted to determine independent role of uric acid in CV morbidity of OSA patients. We aimed to assess the role of serum uric acid as a potential mechanism of CV morbidity in a nonselected cohort of OSA patients. METHODS: This was a cohort study in which patients who had undergone a formal sleep study for diagnosis of OSA were recruited...
June 2014: European Journal of Internal Medicine
Kenichi Ishizawa
Tumor lysis syndrome(TLS)is a life-threatening metabolic abnormality caused by the massive and abrupt release of tumor cell components into the blood. TLS can be classified as laboratory TLS(LTLS)or clinical TLS(CTLS). LTLS is characterized by 2 or more of the following metabolic abnormalities: hyperuricemia, hyperkalemia, and hyperphosphatemia. CTLS comprises LTLS in addition to 1 or more of the following symptoms: renal insufficiency, cardiac arrhythmia/sudden death, and seizures. The prevention and treatment of TLS includes rigorous hydration, hyperuricemia management, and frequent monitoring of electrocytes and correction of electrolyte abnormalities...
February 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Denish Mika, Sabrina Ahmad, C Guruvayoorappan
The tumour lysis syndrome (TLS) is a group of metabolic abnormalities caused by rapid and unexpected release of cellular components into the circulation as a result of massive destruction of rapidly proliferating malignant cells. It usually develops in patients with hematologic malignancies like acute lymphoid leukemia, non-Hodgkin and Burkitt's lymphoma after initiation of chemotherapy or may, rarely, occur spontaneously. Though TLS is seldom observed in relation to solid tumours, there have been reports of connections with examples such as lung, liver, breast, gastric carcinomas...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Danica Maria Vodopivec, Jose Enrique Rubio, Alessia Fornoni, Oliver Lenz
Tumor lysis syndrome (TLS) is characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and secondary hypocalcemia in patients with a malignancy. When these laboratory abnormalities develop rapidly, clinical complications such as cardiac arrhythmias, acute renal failure, seizures, or death may occur. TLS is caused by rapid release of intracellular contents by dying tumor cells, a condition that is expected to be common in hematologic malignancies. However, TLS rarely occurs with solid tumors, and here we present the second chemotherapy-induced TLS in a patient with advanced gastric adenocarcinoma to be reported in the literature...
2012: Case Reports in Medicine
M Resl, M Clodi, S Neuhold, H Kromoser, M Riedl, G Vila, R Prager, R Pacher, G Strunk, A Luger, M Hülsmann
BACKGROUND: Hyperuricemia is a risk factor for cardiovascular events and renal insufficiency. It correlates to intima-media thickness and microalbuminuria. In this study we evaluated uric acid as an independent marker for cardiac events in patients with diabetes. METHODS: In a prospective observational study we recruited 494 patients with diabetes. Patients were then followed for 12.8 months (mean follow-up) and hospitalizations as a result of cardiac events (ischaemic heart disease, arrhythmias, heart failure) were recorded...
June 2012: Diabetic Medicine: a Journal of the British Diabetic Association
M Rodriguez, M Campara, Christina Haaf
Tumor lysis syndrome (TLS) is an oncological emergency consisting of several metabolic derangements: hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. The rupture of tumor cells in cancer patients can be spontaneous or caused by anticancer therapy. Clinical manifestations of TLS include nausea, anorexia, arrhythmias or renal failure. Prevention and treatment measures include aggressive hydration and concomitant antihyperuricemic therapy. Allopurinol has historically been the only available pharmacological option...
August 2011: Drugs of Today
Tariq I Mughal, A Ahsan Ejaz, John R Foringer, Bertrand Coiffier
Tumor lysis syndrome (TLS) is a potentially life-threatening metabolic disorder that occurs when tumor cells undergo rapid decomposition spontaneously or in response to cytoreductive therapy. Delayed recognition of the metabolic imbalances caused by the massive release of tumor cell contents may result in clinical complications such as acute kidney injury, seizures, and cardiac arrhythmias. Prevention, the key principle in TLS management, relies on the identification of patients at risk for developing TLS during chemotherapy or because of disease progression...
April 2010: Cancer Treatment Reviews
Rachel S Bercovitz, Brian S Greffe, Stephen P Hunger
Acute tumor lysis syndrome (TLS) is characterized by the triad of hyperuricemia, hyperkalemia, and hyperphosphatemia and is caused by the death of tumor cells and release of intracellular contents into the circulation. This syndrome is most frequently associated with hematopoietic malignancies with a high growth fraction, including acute leukemias and lymphomas, but can be encountered in patients with nonhematopoietic solid tumors. Acute tumor lysis is typically precipitated by chemotherapy leading to rapid cell death, but may also occur spontaneously prior to treatment...
February 2010: Current Opinion in Pediatrics
A Sirelkhatim, D Sejnova, J Puskacova, Z Subova, E Kaiserova
Tumor lysis syndrome (TLS) is caused by rapid tumor cell turnover resulting in a release of intracellular contents into the circulation, and subsequent numerous metabolic derangements (hyperkalemia, hypocalcemia, hyperphosphatemia, hyperuricemia). More than 90% of cases have laboratory manifestations, and only about 10% have clinical manifestations. The main complications are acute renal failure, cardiac arrhythmia and metabolic acidosis. The management of TLS consists of preventive measures in high-risk patients prior to cancer treatment as well as prompt initiation of supportive care for patients who develop acute tumor lysis syndrome during treatment...
2008: Bratislavské Lekárske Listy
Ken Ohta, Yoshinosuke Fukuchi, Lawrence Grouse, Ryuji Mizutani, Klaus F Rabe, Stephen I Rennard, Nan-Shan Zhong
A large-scale prospective study was conducted in 3810 Japanese elderly (> or =65 years old) patients with asthma or chronic obstructive pulmonary disease (COPD) who had been treated with sustained-release theophylline tablets (THEODUR) at a dose of 400 mg/day for 1-6 months, in principle. Among 3798 protocol-complying patients (mean age: 73.8 +/- 0.10 years, 1997 with COPD), 261 theophylline-related adverse events were observed in 179 (4.71%) patients. The 5 most frequently observed adverse events were "nausea" (40 episodes, 1...
October 2004: Respiratory Medicine
Kuan-Chia Lin, Hsuan-Ming Tsao, Chen-Huan Chen, Pesus Chou
OBJECTIVE: A 7-year followup study among men with hyperuricemia was conducted to study the longterm relationships between serum uric acid concentrations and cardiovascular diseases. Any interaction between uric acid levels and other risk factors (e.g., obesity, hypertension) on the development of cardiovascular diseases was also examined. METHODS: A total of 391 men with hyperuricemia aged 30 and over screened from the community-based Kinmen study in 1991-92 (the baseline study) were followed in 1997-98, with a 75% followup rate...
June 2004: Journal of Rheumatology
Carlo Magelli, Gaia Magnani, Francesco Grigioni, Fabio Coccolo, Luciano Potena, Ornella Leone, Bruno Magnani
Heart transplantation has become a more and more effective therapeutic strategy in severe heart failure patients. An opportune management of the several medical, immunological and psychological complications, that may occur during heart transplant recipients' life, is mandatory to succeed in this therapeutic approach. Indeed, thanks to heart transplantation, recipients may recover from a lethal cardiovascular disease, but on the other hand, they may encounter several co-morbidities. An optimized management has to involve not only the referring Transplant Center, but also the single patient's personal cardiologist and general physician...
April 2003: Italian Heart Journal. Supplement: Official Journal of the Italian Federation of Cardiology
Taku Inoue, Mitsuteru Matsuoka, Kazufumi Nagahama, Chiho Iseki, Takashi Touma, Kunitoshi Iseki, Kozen Kinjo, Shuichi Takishita
We evaluated the association between pulse pressure (PP) and cardiovascular risk factors in a screened cohort. Individuals who were receiving medications for hypertension or heart disease, who had no ECG record, or who had a record of arrhythmia were excluded. In total, 8,508 subjects (5,299 men and 3,209 women; age range, 18 to 89 years) were studied. Subjects were divided into four PP classes: PP.1 (PP < or = 40 mmHg, n=2,127), PP.2 (40 < or = PP < or = 44 mmHg, n=2,127), PP.3 (44 < or = PP < or = 50 mmHg, n=2,127) and PP...
February 2003: Hypertension Research: Official Journal of the Japanese Society of Hypertension
H Kondo, T Kawamura, M Hirai, A Tamakoshi, K Wakai, T Terazawa, S Osugi, M Ohno, N Okamoto, T Tsuchida, Y Ohno, J Toyama
UNLABELLED: BACKGROUND; Few studies have focused on sudden death among apparently healthy workers, and the risk factors have not been fully discussed. METHODS: A nested case-control study was conducted among 164,017 male employees receiving annual medical checkups in Japan. Most recent medical checkup data of 242 sudden death victims (mean age, 48.0 years) were compared with corresponding data of 505 age-, workplace-, and job-type-matched male controls. Odds ratios (ORs) and their 95% confidence intervals (CIs) for each variable were calculated by logistic regression...
August 2001: Preventive Medicine
I S Woo, J S Kim, M J Park, M S Lee, R W Cheon, H M Chang, J S Ahn, J A Lee, Y I Park, Y S Park, J W Shim, I Yang
Acute tumor lysis syndrome (TLS) occurs frequently in hematologic malignancies such as high-grade lymphomas and acute leukemia, which are rapidly proliferating and chemosensitive tumors. It occurs rarely in solid tumors and has never been reported in gastric adenocarcinoma. Typical biochemical findings of acute tumor lysis syndrome are hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia in patients with a malignancy. Rapid changes of these electrolytes may cause cardiac arrhythmia, seizure, acute renal failure and sudden death...
February 2001: Journal of Korean Medical Science
D Schmidt
BACKGROUND: For assessing the prognosis of a branch retinal artery occlusion (BRAO), examination of the arterial blood flow by fluorescein angiography is necessary. PATIENTS AND METHODS: In seven patients (mean age: 68.1, youngest 61, oldest 76 years old), with BRAO of varying involvement and extent, the disturbed retinal blood flow was demonstrated by this method. All the patients were subjected to Doppler sonography of the carotid arteries and all had a general medical examination...
December 16, 1999: European Journal of Medical Research
F X Pi-Sunyer
PURPOSE: The evidence with regard to the relationship of obesity with medical comorbidities was assessed and priority research issues identified. METHODS: The existing literature in English was surveyed. RESULTS: The evidence is overwhelming on the association of obesity to a number of medical conditions. These include: insulin resistance, glucose intolerance, diabetes mellitus, hypertension, dyslipidemia, sleep apnea, arthritis, hyperuricemia, gall bladder disease, and certain types of cancer...
November 1999: Medicine and Science in Sports and Exercise
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