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https://www.readbyqxmd.com/read/29364334/extrahepatic-manifestations-associated-with-chronic-hepatitis-c-virus-infection
#1
A Flores-Chávez, J A Carrion, X Forns, M Ramos-Casals
Chronic hepatitis C virus (HCV) infection has been associated with both organ-specific and systemic autoimmune diseases, with cryoglobulinemia being the most frequent associated disease. Experimental, virologic, and clinical evidence have demon-strated a close association between HCV infection and some systemic autoimmune diseases, especially Sjögren's syndrome, but also rheumatoid arthritis and lupus. A higher prevalence of hematological processes has also been described in patients with HCV infection, including cytopenias and lymphoproliferative disorders (B-cell lymphoma)...
December 2017: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/29344005/biological-clocks-their-relevance-to-immune-allergic-diseases
#2
REVIEW
Roberto Paganelli, Claudia Petrarca, Mario Di Gioacchino
The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention to the importance of circadian rhythms. These originate from a central pacemaker in the suprachiasmatic nucleus in the brain, photoentrained via direct connection with melanopsin containing, intrinsically light-sensitive retinal ganglion cells, and it projects to periphery, thus creating an inner circadian rhythm...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29128174/health-related-quality-of-life-in-men1-patients-compared-with-other-chronic-conditions-and-the-united-states-general-population
#3
Benjamin J Peipert, Sneha Goswami, Susan E Yount, Cord Sturgeon
BACKGROUND: Health-related quality of life (HRQOL) in multiple endocrine neoplasia type-1 (MEN-1) is poorly described. HRQOL in MEN-1 was compared with other chronic conditions and the US general population. METHODS: Adults aged ≥18 years recruited from an MEN-1 support group (n=153) completed the Patient-Reported Outcomes Measurement Information System (PROMIS) 29-item profile. MEN-1 scores were compared with PROMIS scores reported in peer-reviewed literature from back pain (n=218), cancer (n=310), congestive heart failure (CHF; n=60), chronic obstructive pulmonary disease (COPD; n=79), major depressive disorder (n=196), rheumatoid arthritis (RA; n=521), neuroendocrine tumors (NET; n=619), and primary hyperparathyroidism (PHPT; n=45) cohorts...
November 8, 2017: Surgery
https://www.readbyqxmd.com/read/29092064/perspectives-on-polycystic-ovary-syndrome-is-polycystic-ovary-syndrome-research-underfunded
#4
Soumia Brakta, Daria Lizneva, Kateryna Mykhalchenko, Adonis Imam, Walidah Walker, Michael P Diamond, Ricardo Azziz
Context: The Polycystic Ovary Syndrome (PCOS) is a common endocrine-metabolic abnormality with a worldwide prevalence of 4%-21%, depending on diagnostic criteria. The National Institutes of Health (NIH) is the largest single funding agency in the world, invests nearly $30.0 billion annually in biomedical research. Evidence Acquisition: Utilizing the NIH RePorter system we searched for all grants awarded by the NIH for PCOS and three other disorders with comparable degrees of morbidity, and similar or lower mortality and prevalences (i...
September 19, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28706407/incidence-of-oral-lichen-planus-in-perimenopausal-women-a-cross-sectional-study-in-western-uttar-pradesh-population
#5
Ravi Prakash Sasankoti Mohan, Akanksha Gupta, Nagaraju Kamarthi, Sangeeta Malik, Sumit Goel, Swati Gupta
BACKGROUND: Hormonal fluctuations during menopause lead to endocrine changes in women, especially in their sex steroid hormone production. Studies have documented the role of estrogen and progesterone (Pg) on autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Lichen planus (LP), an autoimmune disorder, seen frequently in perimenopausal women, may also get affected by sex steroid hormones, but no direct relationship has been established yet...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28690611/insight-into-the-endocrine-system-and-the-immune-system-a-review-of-the-inflammatory-role-of-prolactin-in-rheumatoid-arthritis-and-psoriatic-arthritis
#6
REVIEW
Man W Tang, Samuel Garcia, Danielle M Gerlag, Paul P Tak, Kris A Reedquist
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects females three times more frequently than males. A potential role for hormones, such as prolactin (PRL), may in part explain this phenomenon. The risk of developing RA is increased in women who are lactating after the first pregnancy, which might be related to breastfeeding and the release of PRL. Other studies found a protective effect of PRL on RA development. Some studies have reported that hyperprolactinemia is more common in RA and serum PRL levels are correlated with several disease parameters, although others could not confirm these findings...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28636167/berberine-ameliorates-collagen-induced-arthritis-in-rats-by-suppressing-th17-cell-responses-via-inducing-cortistatin-in-the-gut
#7
Mengfan Yue, Yufeng Xia, Can Shi, Chunge Guan, Yunfan Li, Rui Liu, Zhifeng Wei, Yue Dai
Berberine, an isoquinoline alkaloid, has been reported to ameliorate various autoimmune diseases including rheumatoid arthritis by oral administration. However, its mechanism remains mysterious due to an extremely low bioavailability. The fact that berberine readily accumulates in the gut, the largest endocrine organ in the body, attracted us to explore its anti-arthritic mechanism in view of the induction of intestinal immunosuppressive neuropeptides. In this study, berberine (200 mg·kg(-1) , i.g.) was shown to ameliorate collagen-induced arthritis in rats, which was manifested by the reduction of clinical signs and joint destruction, as well as marked down-regulation of Th17 cell frequency and interleukin-17 level in blood...
September 2017: FEBS Journal
https://www.readbyqxmd.com/read/28458654/multiple-roles-of-angiopoietin-like-4-in-osteolytic-disease
#8
REVIEW
Helen J Knowles
Hypoxia and the hypoxia-inducible factor (HIF) transcription factor drive pathological bone loss in conditions including rheumatoid arthritis (RA), osteoarthritis, osteoporosis, primary bone tumours, and bone metastatic cancer. There is therefore considerable interest in determining the function(s) of HIF-induced genes in these pathologies. Angiopoietin-like 4 (ANGPTL4) is an adipose-derived, HIF-1α- and PPARγ-induced gene that was originally discovered as an endocrine and autocrine/paracrine regulator of lipid metabolism...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28405546/arthropathy-in-dermatology-a-comprehensive-review
#9
REVIEW
Soumya Jagadeesan, Padmanabha Shenoy
Dermatology and rheumatology are two specialties that deal with significant overlap. In this context, it is important that the dermatologists acquaint themselves with conditions presenting with arthropathy. As the first step, it is essential to know whether the origin of musculoskeletal symptom is articular or extra-articular; inflammatory or noninflammatory; acute or chronic; oligo- or poly-articular. This will help in narrowing down the differential diagnoses as well as in better correlation with the cutaneous symptoms...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28389989/single-vagus-nerve-stimulation-reduces-early-postprandial-c-peptide-levels-but-not-other-hormones-or-postprandial-metabolism
#10
M W Tang, F S van Nierop, F A Koopman, H M Eggink, D M Gerlag, M W Chan, R Zitnik, F M Vaz, J A Romijn, P P Tak, M R Soeters
A recent study in rheumatoid arthritis (RA) patients using electrical vagus nerve stimulation (VNS) to activate the inflammatory reflex has shown promising effects on disease activity. Innervation by the autonomic nerve system might be involved in the regulation of many endocrine and metabolic processes and could therefore theoretically lead to unwanted side effects. Possible effects of VNS on secretion of hormones are currently unknown. Therefore, we evaluated the effects of a single VNS on plasma levels of pituitary hormones and parameters of postprandial metabolism...
April 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28386080/differential-activation-of-endocrine-immune-networks-by-arthritis-challenge-insights-from-colony-specific-responses
#11
Tamara S Bodnar, Matthew D Taves, Katie M Lavigne, Todd S Woodward, Kiran K Soma, Joanne Weinberg
Rheumatoid arthritis (RA) is a chronic inflammatory condition with variable clinical presentation and disease progression. Importantly, animal models of RA are widely used to examine disease pathophysiology/treatments. Here, we exploited known vendor colony-based differences in endocrine/immune responses to gain insight into inflammatory modulators in arthritis, utilizing the adjuvant-induced arthritis (AA) model. Our previous study found that Sprague-Dawley (SD) rats from Harlan develop more severe AA, have lower corticosteroid binding globulin, and have different patterns of cytokine activation in the hind paw, compared to SD rats from Charles River...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27821712/bruton-s-tyrosine-kinase-small-molecule-inhibitors-induce-a-distinct-pancreatic-toxicity-in-rats
#12
Rebecca I Erickson, Leah K Schutt, Jacqueline M Tarrant, Michelle McDowell, Lichuan Liu, Adam R Johnson, Sock-Cheng Lewin-Koh, Maj Hedehus, Jed Ross, Richard A D Carano, Karin Staflin, Fiona Zhong, James J Crawford, Shelly Zhong, Karin Reif, Arna Katewa, Harvey Wong, Wendy B Young, Donna M Dambach, Dinah L Misner
Bruton's tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule inhibitors of BTK are being investigated for treatment of several hematologic cancers and autoimmune diseases. GDC-0853 ((S)-2-(3'-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl)-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one) is a selective and reversible oral small-molecule BTK inhibitor in development for the treatment of rheumatoid arthritis and systemic lupus erythematosus...
January 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27686101/the-role-of-female-hormonal-factors-in-the-development-of-rheumatoid-arthritis
#13
REVIEW
Deshiré Alpízar-Rodríguez, Nicola Pluchino, Geraldine Canny, Cem Gabay, Axel Finckh
RA is the most common chronic systemic autoimmune disease, with a higher prevalence in women, suggesting female hormonal factors play a role in the development of the disease. However, many controversies still exist. The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development. The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime and interact with various environmental, immunological, genetic and endocrine factors influencing the development of autoimmunity...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27484684/vitamin-d-deficiency-and-rheumatoid-arthritis
#14
REVIEW
Larissa Lumi Watanabe Ishikawa, Priscila Maria Colavite, Thais Fernanda de Campos Fraga-Silva, Luiza Ayumi Nishiyama Mimura, Thais Graziela Donegá França, Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Larissa Doddi Marcolino, Marcimara Penitenti, Maura Rosane Valerio Ikoma, Alexandrina Sartori
Vitamin D (VitD) is a hormone primarily synthesized in human skin under the stimulation of ultraviolet radiation. Beyond its endocrine role in bone metabolism, VitD is endowed with remarkable immunomodulatory properties. The effects of VitD on the immune system include the enhancement of microbicidal ability of monocytes/macrophages and the down-modulation of inflammatory cytokines produced by T lymphocytes. VitD deficiency is involved in many health problems, including immune-mediated diseases such as autoimmune disorders...
June 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27312420/pollutants-make-rheumatic-diseases-worse-facts-on-polychlorinated-biphenyls-pcbs-exposure-and-rheumatic-diseases
#15
Vanessa Abella, Tamara Pérez, Morena Scotece, Javier Conde, Claudio Pirozzi, Jesús Pino, Francisca Lago, Miguel Ángel González-Gay, Antonio Mera, Rodolfo Gómez, Oreste Gualillo
BACKGROUND: Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bioaccumulate in adipose tissue, disturbing its metabolism and the balance of adipokines, related to obesity. The altering secretion pattern of adipokines from the adipose tissue and the increasing mechanical load in weight-bearing joints presented in obesity condition, are risk factors for osteoarthritis development. The most prevalent rheumatic diseases, osteoarthritis and rheumatoid arthritis, are chronic conditions that target the whole joints, leading to increasing disability and health care cost...
July 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27117610/-osteoimmunology-overview
#16
REVIEW
Takehito Ono, Hiroshi Takayanagi
Bone serves not only as a locomotive organ but also as an organ instrumental in many other functions such as hematopoiesis. To this end, bone undergoes renewal by sequential resorption and formation. Bone resorption and formation are regulated by many systems including the endocrine, the nervous and the immune systems. The skeletal and the immune systems are closely related because they share many regulatory molecules such as cytokines and transcription factors. Studies on such shared molecules and inflammatory bone destruction in rheumatoid arthritis have fostered a novel interdisciplinary field, "osteoimmunology"...
May 2016: Clinical Calcium
https://www.readbyqxmd.com/read/26968919/salivary-proteomics-a-new-adjuvant-approach-to-the-early-diagnosis-of-familial-juvenile-systemic-lupus-erythematosus
#17
Aline Lauria P Abrão, Denise Pinheiro Falcao, Rivadávio Fernandes Batista de Amorim, Ana Cristina B Bezerra, Gilson Augusto N M Pombeiro, Luciano Junqueira Guimarães, Felipe Fregni, Luciano Paulino Silva, Licia Maria Henrique da Mota
Systemic lupus erythematosus (SLE) is a chronic multisystemic disease characterized by autoimmune inflammatory disturbance. Pleomorphic manifestations are present and a potentially progressive and debilitating course can be detected. SLE rarely manifests before age 5, and its onset peaks is around puberty. Although clinical manifestations, immunological alterations and treatment do not differ between juvenile and adult SLE, children tend to present with a more aggressive disease course than adults. Hence, autoimmune rheumatic diseases are the most common cause of morbidity and mortality in pediatric populations...
April 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/26924790/heterophilic-antibody-interference-affecting-multiple-hormone-assays-is-it-due-to-rheumatoid-factor
#18
Shiva Mongolu, Annie E Armston, Erin Mozley, Azraai Nasruddin
Assay interference with heterophilic antibodies has been well described in literature. Rheumatoid factor is known to cause similar interference leading to falsely elevated hormone levels when measured by immunometric methods like enzyme-linked immunosorbent assay (ELISA) or multiplex immunoasays (MIA). We report a case of a 60-year-old male patient with a history of rheumatoid arthritis referred to our endocrine clinic for investigation of hypogonadism and was found to have high serum levels of LH, FSH, SHBG, Prolactin, HCG and TSH...
2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/26877323/p3-24-secondary-hypertension-in-a-tunisian-internal-medicine-department
#19
Y Ben Ariba, A Tliba, B Louzir, J Labidi, S Othmani
BACKGROUND: Secondary hypertension (SH) refers to arterial hypertension due to an identifiable and often curable cause. It affects approximately 5-10% of the general hypertensive population. SH can be caused by conditions that affect kidneys, arteries, heart or endocrine system. Our aim is to describe the different causes of SH noted in our patients. METHODS: It is a retrospective study of 240 patients followed for a SH at the Internal Medicine Department of the Tunisian Military Hospital from 2000 to 2015...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26608858/-management-of-osteoporosis-associated-with-rheumatoid-arthritis-and-glucocorticoid-induced-osteoporosis
#20
Yasuo Suzuki, Takayuki Wakabayashi
Mechanism of generalized osteoporosis associated with rheumatoid arthritis(RA)is multifactorial and following factors has been proposed:systemic effect of RA synovitis, glucocorticoids, weight loss, and endocrine changes. In addition to control of RA inflammation and management of glucocorticoid-induced osteoporosis(GIO), antiresorptive therapy, such as bisphosphonates is expected to show efficacy. Recently, anti-RANKL monoclonal antibodies have been shown to inhibit bone erosion and bone loss in combination with methotrexate in RA...
December 2015: Clinical Calcium
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