keyword
MENU ▼
Read by QxMD icon Read
search

Endocrine, rheumatoid

keyword
https://www.readbyqxmd.com/read/27821712/btk-small-molecule-inhibitors-induce-a-distinct-pancreatic-toxicity-in-rats
#1
Rebecca I Erickson, Leah K Schutt, Jacqueline Tarrant, Michelle McDowell, Lichuan Liu, Adam R Johnson, Sock-Cheng Lewin-Koh, Maj Hedehus, Jed Ross, Richard A D Carano, Karin Staflin, Fiona Zhong, James Crawford, Shelly Zhong, Karin Reif, Arna Katewa, Harvey Wong, Wendy Young, Donna Dambach, Dinah Misner
Bruton's tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule inhibitors of BTK are being investigated for treatment of several hematological cancers and autoimmune diseases. GDC-0853 is a selective and reversible oral small molecule BTK inhibitor in development for the treatment of rheumatoid arthritis and systemic lupus erythematosus. In Sprague-Dawley (SD) rats, administration of GDC-0853 and other structurally diverse BTK inhibitors for 7 days or longer caused pancreatic lesions consisting of multifocal islet-centered hemorrhage, inflammation, fibrosis, and pigment-laden macrophages with adjacent lobular exocrine acinar cell atrophy, degeneration, and inflammation...
November 7, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27686101/the-role-of-female-hormonal-factors-in-the-development-of-rheumatoid-arthritis
#2
Deshiré Alpízar-Rodríguez, Nicola Pluchino, Geraldine Canny, Cem Gabay, Axel Finckh
RA is the most common chronic systemic autoimmune disease, with a higher prevalence in women, suggesting female hormonal factors play a role in the development of the disease. However, many controversies still exist. The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development. The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime and interact with various environmental, immunological, genetic and endocrine factors influencing the development of autoimmunity...
September 29, 2016: Rheumatology
https://www.readbyqxmd.com/read/27484684/vitamin-d-deficiency-and-rheumatoid-arthritis
#3
REVIEW
Larissa Lumi Watanabe Ishikawa, Priscila Maria Colavite, Thais Fernanda de Campos Fraga-Silva, Luiza Ayumi Nishiyama Mimura, Thais Graziela Donegá França, Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Larissa Doddi Marcolino, Marcimara Penitenti, Maura Rosane Valerio Ikoma, Alexandrina Sartori
Vitamin D (VitD) is a hormone primarily synthesized in human skin under the stimulation of ultraviolet radiation. Beyond its endocrine role in bone metabolism, VitD is endowed with remarkable immunomodulatory properties. The effects of VitD on the immune system include the enhancement of microbicidal ability of monocytes/macrophages and the down-modulation of inflammatory cytokines produced by T lymphocytes. VitD deficiency is involved in many health problems, including immune-mediated diseases such as autoimmune disorders...
August 2, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27312420/pollutants-make-rheumatic-diseases-worse-facts-on-polychlorinated-biphenyls-pcbs-exposure-and-rheumatic-diseases
#4
Vanessa Abella, Tamara Pérez, Morena Scotece, Javier Conde, Claudio Pirozzi, Jesús Pino, Francisca Lago, Miguel Ángel González-Gay, Antonio Mera, Rodolfo Gómez, Oreste Gualillo
BACKGROUND: Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bioaccumulate in adipose tissue, disturbing its metabolism and the balance of adipokines, related to obesity. The altering secretion pattern of adipokines from the adipose tissue and the increasing mechanical load in weight-bearing joints presented in obesity condition, are risk factors for osteoarthritis development. The most prevalent rheumatic diseases, osteoarthritis and rheumatoid arthritis, are chronic conditions that target the whole joints, leading to increasing disability and health care cost...
July 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27117610/-osteoimmunology-overview
#5
REVIEW
Takehito Ono, Hiroshi Takayanagi
Bone serves not only as a locomotive organ but also as an organ instrumental in many other functions such as hematopoiesis. To this end, bone undergoes renewal by sequential resorption and formation. Bone resorption and formation are regulated by many systems including the endocrine, the nervous and the immune systems. The skeletal and the immune systems are closely related because they share many regulatory molecules such as cytokines and transcription factors. Studies on such shared molecules and inflammatory bone destruction in rheumatoid arthritis have fostered a novel interdisciplinary field, "osteoimmunology"...
May 2016: Clinical Calcium
https://www.readbyqxmd.com/read/26968919/salivary-proteomics-a-new-adjuvant-approach-to-the-early-diagnosis-of-familial-juvenile-systemic-lupus-erythematosus
#6
Aline Lauria P Abrão, Denise Pinheiro Falcao, Rivadávio Fernandes Batista de Amorim, Ana Cristina B Bezerra, Gilson Augusto N M Pombeiro, Luciano Junqueira Guimarães, Felipe Fregni, Luciano Paulino Silva, Licia Maria Henrique da Mota
Systemic lupus erythematosus (SLE) is a chronic multisystemic disease characterized by autoimmune inflammatory disturbance. Pleomorphic manifestations are present and a potentially progressive and debilitating course can be detected. SLE rarely manifests before age 5, and its onset peaks is around puberty. Although clinical manifestations, immunological alterations and treatment do not differ between juvenile and adult SLE, children tend to present with a more aggressive disease course than adults. Hence, autoimmune rheumatic diseases are the most common cause of morbidity and mortality in pediatric populations...
April 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/26924790/heterophilic-antibody-interference-affecting-multiple-hormone-assays-is-it-due-to-rheumatoid-factor
#7
Shiva Mongolu, Annie E Armston, Erin Mozley, Azraai Nasruddin
Assay interference with heterophilic antibodies has been well described in literature. Rheumatoid factor is known to cause similar interference leading to falsely elevated hormone levels when measured by immunometric methods like enzyme-linked immunosorbent assay (ELISA) or multiplex immunoasays (MIA). We report a case of a 60-year-old male patient with a history of rheumatoid arthritis referred to our endocrine clinic for investigation of hypogonadism and was found to have high serum levels of LH, FSH, SHBG, Prolactin, HCG and TSH...
2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/26877323/p3-24-secondary-hypertension-in-a-tunisian-internal-medicine-department
#8
Y Ben Ariba, A Tliba, B Louzir, J Labidi, S Othmani
BACKGROUND: Secondary hypertension (SH) refers to arterial hypertension due to an identifiable and often curable cause. It affects approximately 5-10% of the general hypertensive population. SH can be caused by conditions that affect kidneys, arteries, heart or endocrine system. Our aim is to describe the different causes of SH noted in our patients. METHODS: It is a retrospective study of 240 patients followed for a SH at the Internal Medicine Department of the Tunisian Military Hospital from 2000 to 2015...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26608858/-management-of-osteoporosis-associated-with-rheumatoid-arthritis-and-glucocorticoid-induced-osteoporosis
#9
Yasuo Suzuki, Takayuki Wakabayashi
Mechanism of generalized osteoporosis associated with rheumatoid arthritis(RA)is multifactorial and following factors has been proposed:systemic effect of RA synovitis, glucocorticoids, weight loss, and endocrine changes. In addition to control of RA inflammation and management of glucocorticoid-induced osteoporosis(GIO), antiresorptive therapy, such as bisphosphonates is expected to show efficacy. Recently, anti-RANKL monoclonal antibodies have been shown to inhibit bone erosion and bone loss in combination with methotrexate in RA...
December 2015: Clinical Calcium
https://www.readbyqxmd.com/read/26025594/the-role-of-leptin-in-the-pathophysiology-of-rheumatoid-arthritis
#10
REVIEW
Éric Toussirot, Fabrice Michel, Delphine Binda, Gilles Dumoulin
The past 20 years of research on leptin has provided important insights into its role in rheumatoid arthritis (RA). Leptin is one of the different adipokines produced by the adipose tissue that influences the endocrine system, energy homeostasis and the immune response in several ways. Leptin is known to have predominantly pro-inflammatory effects, especially in the setting of chronic inflammation. Animal models of arthritis have illustrated well the participation of leptin in the inflammatory response within the joints...
November 1, 2015: Life Sciences
https://www.readbyqxmd.com/read/25888974/estrogen-regulates-t-helper-17-phenotype-and-localization-in-experimental-autoimmune-arthritis
#11
Annica Andersson, Alexandra Stubelius, Merja Nurkkala Karlsson, Cecilia Engdahl, Malin Erlandsson, Louise Grahnemo, Marie K Lagerquist, Ulrika Islander
INTRODUCTION: The incidence and progression of many autoimmune diseases are sex-biased, which might be explained by the immunomodulating properties of endocrine hormones. Treatment with estradiol potently inhibits experimental autoimmune arthritis. Interleukin-17-producing T helper cells (Th17) are key players in several autoimmune diseases, particularly in rheumatoid arthritis. The aim of this study was to investigate the effects of estrogen on Th17 cells in experimental arthritis. METHODS: Ovariectomized DBA/1 mice treated with 17β-estradiol (E2) or placebo were subjected to collagen-induced arthritis (CIA), and arthritis development was assessed...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25836921/oral-curcumin-has-anti-arthritic-efficacy-through-somatostatin-generation-via-camp-pka-and-ca-2-camkii-signaling-pathways-in-the-small-intestine
#12
Yan Yang, Xin Wu, Zhifeng Wei, Yannong Dou, Di Zhao, Ting Wang, Difei Bian, Bei Tong, Ying Xia, Yufeng Xia, Yue Dai
Curcumin (CUR) has been proven to be clinically effective in rheumatoid arthritis (RA) therapy, but its low oral bioavailability eclipses existent evidence that attempts to explain the underlying mechanism. Small intestine, the only organ exposed to a relatively high concentration of CUR, is the main site that generates gut hormones which are involved in the pathogenesis of RA. This study aims at addressing the hypothesis that one or more gut hormones serve as an intermediary agent for the anti-arthritic action of CUR...
May 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/25820382/uncovering-pharmacological-mechanisms-of-wu-tou-decoction-acting-on-rheumatoid-arthritis-through-systems-approaches-drug-target-prediction-network-analysis-and-experimental-validation
#13
Yanqiong Zhang, Ming Bai, Bo Zhang, Chunfang Liu, Qiuyan Guo, Yanqun Sun, Danhua Wang, Chao Wang, Yini Jiang, Na Lin, Shao Li
Wu-tou decoction (WTD) has been extensively used for the treatment of rheumatoid arthritis (RA). Due to lack of appropriate methods, pharmacological mechanisms of WTD acting on RA have not been fully elucidated. In this study, a list of putative targets for compositive compounds containing in WTD were predicted by drugCIPHER-CS. Then, the interaction network of the putative targets of WTD and known RA-related targets was constructed and hub nodes were identified. After constructing the interaction network of hubs, four topological features of each hub, including degree, node betweenness, closeness and k-coreness, were calculated and 79 major hubs were identified as candidate targets of WTD, which were implicated into the imbalance of the nervous, endocrine and immune (NEI) systems, leading to the main pathological changes during the RA progression...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25764919/-etiologies-and-clinical-features-of-19-cases-with-bilateral-acute-sensorineural-hearing-loss
#14
Xiaowei Gao, Liyan Liu, Yongwang Huang, Hongmei Lu, Jie Ouyang, Yanyou Wang
OBJECTIVE: To investigate the etiologies and clinical features for bilateral acute sensorineural hearing loss (bi-ASNHL). METHODS: The clinical data of 19 cases presenting with bi-ASNHL were retrospectively analyzed, including the clinical features, systemic examinations, laboratory examinations, audiology and radiology results, as well as the prognosis. RESULTS: There were 15 non-otologic diseases in 19 patients, accounting for 78.9% of the total cases, most of which were disorders with multisystem and multi-organ disorder...
January 2015: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/25550090/interdisciplinary-exchange-of-ideas-progestagens-for-autoimmunity-biologics-for-pregnancy-complications
#15
REVIEW
Abraham Tsur, Grant C Hughes, Yehuda Shoenfeld, Howard Carp
In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm labor have elevated inflammatory markers such as tumor necrosis factor alpha, interleukin 6 and matrix metaloproeinase 8. The role of immune processes in the pathogenesis of recurrent pregnancy loss has also been widely researched...
February 2015: Immunologic Research
https://www.readbyqxmd.com/read/25502945/genetics-of-neuroendocrine-factors-in-rheumatoid-arthritis
#16
M Mravcova, L Chovanova, L Paulikova, M Vlcek, J Rovensky, Z Killinger, J Wendl, R Imrich
Inadequate production of cortisol related to inflammation and decrease in adrenal androgen production are hallmarks of hypothalamic-pituitary-adrenal (HPA)-related endocrine findings in rheumatoid arthritis (RA). In particular, lower dehydroepiandrosterone sulfate (DHEAS) levels were consistently found in a subset of premenopausal RA females. Recently, several new gene variants have been identified in association with serum DHEAS concentrations, such as in SULT2A1 and HHEX genes. These DHEAS-related genes and other variants involved in HPA regulation may play a role in the adrenal androgen deficiency in RA...
June 2015: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/25478383/rheumatologic-manifestations-in-iranian-patients-with-autoimmune-thyroid-diseases
#17
Sharabeh Hezarkhani, Sima Sedighi, Mehrdad Aghaei, Maryam Shamekhi, Mahin Nomali
BACKGROUND: Autoimmune thyroid diseases (ATDs) are the most common endocrine diseases which result in rheumatologic manifestations. Some studies have shown association between rheumatologic disorders and ATDs. Thus, the aim of this study was to assess the frequency of rheumatologic manifestations in patients with ATDs. MATERIALS AND METHODS: In this cross-sectional descriptive study during 2010 to 2011, 65 patients with ATDs referred to the Rheumatology clinic of 5 Azar Hospital in Gorgan (North of Iran) were studied via systematic random sampling and patients with positive antithyroid peroxides (anti-TPO) were included in the study...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25308530/is-vitamin-d-a-player-or-not-in-the-pathophysiology-of-autoimmune-thyroid-diseases
#18
REVIEW
Federica D'Aurizio, Danilo Villalta, Paolo Metus, Paolo Doretto, Renato Tozzoli
1,25-Dihydroxyvitamin D is a steroid hormone derived from vitamin D, playing an important role in maintaining an adequate serum level of calcium and phosphorus. It is now clear that vitamin D exerts an endocrine action on the cells of the immune system, generating anti-inflammatory and immunoregulatory effects. The mechanisms underlying the role of vitamin D in autoimmunity are not completely understood. Lower vitamin D levels have been found in several autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, type 1 diabetes mellitus, multiple sclerosis, inflammatory bowel diseases, autoimmune thyroid diseases (i...
May 2015: Autoimmunity Reviews
https://www.readbyqxmd.com/read/25245644/epigenetics-in-autoimmune-connective-tissue-diseases
#19
Giovanni Delsante, Pieranna Fietta
UNLABELLED: Background. Autoimmune connective tissue diseases (ACTDs) encompass a heterogeneous group of chronic immune-mediated inflammatory disorders, primarily affecting connective tissues and clinically characterized by variable multisystem manifestations, frequently overlapping. Environmental factors are thought to promote ACTD development in genetic predisposing/endocrine permissive background through the induction of epigenetic modifications, consisting of stable, heritable, but potentially reversible changes in gene expression, occurring without alterations of the DNA sequence...
2014: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/25185856/a-case-of-autoimmune-urticaria-accompanying-autoimmune-polyglandular-syndrome-type-iii-associated-with-hashimoto-s-disease-type-1-diabetes-mellitus-and-vitiligo
#20
Jacek Kasznicki, Józef Drzewoski
We present a case of autoimmune polyglandular syndrome type III (APS III) associated with Hashimoto's disease, type 1 diabetes mellitus, vitiligo and autoimmune urticaria. This rare genetic disorder occurs with unknown frequency in the Polish population. It is characterised by endocrine tissue destruction resulting in the malfunction of multiple organs.Several cases of APS III associated with organ-specific autoimmune diseases such as coeliac disease, hypogonadism and myasthenia gravis, as well as organ-nonspecific or systemic autoimmune diseases such as sarcoidosis, Sjögren syndrome, and rheumatoid arthritis have been described...
2014: Endokrynologia Polska
keyword
keyword
70005
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"