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https://www.readbyqxmd.com/read/28205376/drug-drug-interactions-in-pediatric-oncology-patients
#1
T E Balk, I H van der Sijs, T van Gelder, J J B Janssen, I M van der Sluis, R W F van Leeuwen, F K Engels
BACKGROUND: Drug-drug interactions (DDIs) can negatively affect pharmacotherapy. However, pediatric DDI studies are scarce. We undertook an exploratory study to investigate prevalence and clinical relevance of DDIs between cytostatic and noncytostatic drugs in outpatient pediatric oncology patients. PROCEDURE: After informed consent and inclusion, the following information was collected: currently prescribed noncytostatic and cytostatic drugs, comorbidities, and use of over-the-counter (OTC) drugs, complementary and alternative medicines (CAMs), and dietary supplements...
February 16, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28196633/old-and-new-oral-anticoagulants-food-herbal-medicines-and-drug-interactions
#2
REVIEW
Alessandro Di Minno, Beatrice Frigerio, Gaia Spadarella, Alessio Ravani, Daniela Sansaro, Mauro Amato, Joseph P Kitzmiller, Mauro Pepi, Elena Tremoli, Damiano Baldassarre
The most commonly prescribed oral anticoagulants worldwide are the vitamin K antagonists (VKAs) such as warfarin. Factors affecting the pharmacokinetics of VKAs are important because deviations from their narrow therapeutic window can result in bleedings due to over-anticoagulation or thrombosis because of under-anticoagulation. In addition to pharmacodynamic interactions (e.g., augmented bleeding risk for concomitant use of NSAIDs), interactions with drugs, foods, herbs, and over-the-counter medications may affect the risk/benefit ratio of VKAs...
February 5, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28193274/evaluation-of-medicines-dispensing-pattern-of-private-pharmacies-in-rajshahi-bangladesh
#3
Shuvashis Saha, Md Tawhid Hossain
BACKGROUND: In developing country like BANGLADESH, people depend more on pharmacies due to expediency, shorter waiting time, cost reduction, availability of credit and flexible opening hours. The aim of this study was to investigate medicines dispensing patterns of the pharmacies in RAJSHAHI, BANGLADESH and to identify and analyze contribution of drugsellers and quacks in irrational drug use. METHODS: This cross-sectional study was conducted during January 2016 - April, 2016 in 75 randomly selected private pharmacies including both licensed and unlicensed pharmacies of covering LAKSHMIPUR area...
February 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28187744/medication-use-by-middle-aged-and-older-participants-of-an-exercise-study-results-from-the-brain-in-motion-study
#4
Tania Pannu, Sarah Sharkey, Grazyna Burek, Daniela Cretu, Michael D Hill, David B Hogan, Marc J Poulin
BACKGROUND: Over the past 50 years, there has been an increase in the utilization of prescribed, over-the-counter (OTC) medications, and natural health products. Although it is known that medication use is common among older persons, accurate data on the patterns of use, including the quantity and type of medications consumed in a generally healthy older population from a Canadian perspective are lacking. In this study, we study the pattern of medication use in a sedentary but otherwise healthy older persons use and determined if there was an association between medication use and aerobic fitness level...
February 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28176957/determinants-of-weight-change-in-patients-on-basal-insulin-treatment-an-analysis-of-the-dive-registry
#5
Peter Bramlage, Tobias Bluhmki, Holger Fleischmann, Matthias Kaltheuner, Jan Beyersmann, Reinhard W Holl, Thomas Danne
OBJECTIVE: We aimed to describe patterns of weight change in insulin-naive patients with type 2 diabetes mellitus (T2DM) starting basal insulin (BI) treatment. RESEARCH DESIGN AND METHODS: Diabetes Versorgungs-Evaluation (DIVE) is an observational, multicenter, prospective registry in patients with T2DM. Patients were divided into those initiating BI therapy for the first time (with optional oral antidiabetic drugs (OADs)) and those initiating OADs only (OADo). RESULTS: 521 patients were included in the analysis, 113 in the BI arm and 408 in the OADo arm...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28163027/pharmacists-readiness-to-provide-naloxone-in-community-pharmacies-in-west-virginia
#6
J Douglas Thornton, Elizabeth Lyvers, Virginia Ginger G Scott, Nilanjana Dwibedi
OBJECTIVES: The objective of this study is to assess West Virginia pharmacists' stocking and dispensing practices of opioid-related medications and to identify the educational needs relating to providing naloxone in community pharmacies. DESIGN: A cross-sectional, anonymous, 49-item survey was created and validated to assess the educational needs of West Virginia community pharmacists. SETTING: West Virginia. PARTICIPANTS: The data collection instrument was administered to 266 pharmacists currently licensed in West Virginia at 6 continuing pharmacy education events throughout the state from March 1 to June 15, 2016...
February 2, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28162966/over-the-counter-antibiotics-in-saudi-arabia-an-urgent-call-for-policy-makers
#7
Sharafaldeen Bin Nafisah, Salahaldin Bin Nafesa, Aliyah H Alamery, Mazen A Alhumaid, Haitham M AlMuhaidib, Fahad A Al-Eidan
Antibiotics over-consumption is a pandemic that has a tremendous cost on the overwhelmed healthcare system. The accessibility of antibiotics coupled with the misconception of public toward those drugs both of which implicated in the use and misuse of antibiotics. The aim of this study was to investigate the perception of the community toward antibiotics, its purpose and harmfulness, in addition to the accessibility of those drugs as over the counter and without prescriptions. We also investigated the behavior toward antibiotic prescriptions when perceived unnecessary...
February 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28158745/changes-in-over-the-counter-drug-misuse-over-20-years-perceptions-from-scottish-pharmacists
#8
Jessica Wright, Christine Bond, Helen D Robertson, Catriona Matheson
No abstract text is available yet for this article.
December 2, 2016: Journal of Public Health
https://www.readbyqxmd.com/read/28148262/demographic-factors-associated-with-dietary-supplement-prescriptions-filled-by-united-states-military-service-members-2005-2013
#9
Joseph J Knapik, Rosenie T Jean, Krista G Austin, Ryan A Steelman, Emily K Farina, Harris R Lieberman
BACKGROUND: Dietary supplements (DSs) can be purchased over-the-counter but may also be prescribed by medical personnel for specific therapeutic reasons. Few studies have examined this latter source of DSs despite the fact that 79% of physicians and 82% of nurses have recommended DSs to their patients. This investigation examined demographic factors associated with temporal trends in oral DS prescriptions filled by all United States (US) service members (SMs) from 2005 to 2013 (n = 1,427,080 ± 22,139, mean ± standard deviation per year)...
January 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28144388/hepatic-structural-enhancement-and-insulin-resistance-amelioration-due-to-at1-receptor-blockade
#10
EDITORIAL
Vanessa Souza-Mello
Over the last decade, the role of renin-angiotensin system (RAS) on the development of obesity and its comorbidities has been extensively addressed. Both circulating and local RAS components are up-regulated in obesity and involved in non-alcoholic fatty liver disease onset. Pharmacological manipulations of RAS are viable strategies to tackle metabolic impairments caused by the excessive body fat mass. Renin inhibitors rescue insulin resistance, but do not have marked effects on hepatic steatosis. However, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARB) yield beneficial hepatic remodeling...
January 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28135825/il-10-gene-polymorphisms-and-self-medication-with-over-the-counter-nonsteroidal-anti-inflammatory-drugs
#11
Stephen J Walsh
BACKGROUND: Genetic influences on self-medication with over-the-counter (OTC) drugs merit investigation. For example, patients frequently use OTC nonsteroidal anti-inflammatory drugs (NSAIDs) to treat inflammation, but the inflammatory response is also affected by endogenous cytokines whose production varies across polymorphisms of their encoding genes. In the case of interleukin 10 (IL-10), literature suggests that a single nucleotide polymorphism (SNP) in the promoter region of the cytokine's gene (-1082 A > G [rs1800896]) influences production with higher levels associated with G variant alleles...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28132418/switching-adverse-effects-and-use-of-over-the-counter-analgesics-among-users-of-oral-anticoagulants-a-pharmacy-based-survey
#12
Maja Hellfritzsch, Lea Maria Rønneberg Hyllested, Line Meegaard, Alexander Wiberg-Hansen, Erik Lerkevang Grove, Anton Pottegård
Oral anticoagulants are widely used but information on important aspects in that respect is not available from medical registers or clinical databases. Therefore, we conducted a survey including patients filling a prescription for oral anticoagulants at two large Danish community pharmacies. We collected information concerning the patients' knowledge of their anticoagulant treatment including prior drug switching. Further, patients were asked about use of over-the-counter analgesics, adverse effects, and how the treatment affected their everyday life...
January 28, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28130022/improving-over-the-counter-medication-safety-for-older-adults-a-study-protocol-for-a-demonstration-and-dissemination-study
#13
Michelle A Chui, Jamie A Stone, Richard J Holden
BACKGROUND: Adverse drug events (ADEs) associated with over-the-counter (OTC) medications cause 178,000 hospitalizations each year. Older adults, aged 65 and older, are particularly vulnerable to ADEs. Of the 2.2 million older adults considered at risk for a major ADE, more than 50% are at risk due to concurrent use of an OTC and prescription medication. OBJECTIVES: To refine the intervention and implementation strategy through diagnostic and formative evaluation; to evaluate the effectiveness of the intervention for preventing misuse of high-risk OTC medications by older adults; and to evaluate the implementation of the intervention in community pharmacies...
January 24, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28127506/chemotherapy-induced-neuropathies-a-growing-problem-for-patients-and-health-care-providers
#14
Marta Banach, Judyta K Juranek, Aneta L Zygulska
INTRODUCTION: Chemotherapy-induced neuropathies are one of the most common side effects of cancer treatment, surpassing bone marrow suppression and kidney dysfunction. Chemotherapy effects on the nervous system vary between different classes of drugs and depend on specific chemical and physical properties of the drug used. The three most neurotoxic classes of anti-cancer drugs are: platinum-based drugs, taxanes, and thalidomide and its analogs; other, less neurotoxic but also commonly used drugs are: bortezomib, ixabepilone, and vinca alkaloids...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28095562/the-efficacy-of-q-switched-nd-yag-1064-nm-laser-in-recalcitrant-macular-amyloidosis-a-case-report
#15
Nevil Khurana, Christine Urman
Macular amyloidosis typically presents as small, dusky-brown or greyish pigmented macules, the result of altered keratin deposition. Treatment of these hyperpigmented regions with topical and systemic therapies remains challenging, however Q-Switched neodymi- um-doped yttrium aluminum garnet (ND:YAG) laser has proven to be an effective treatment modality to reduce hyperpigmentation. In this case report we investigated the ef cacy of Q-Switched Nd:YAG laser treatment on a 34-year old woman with recalcitrant macular amyloidosis who failed to respond to over-the-counter bleaching creams...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095538/exogenous-factors-in-skin-barrier-repair
#16
Julia Schwartz, Adam J Friedman
The stratum corneum (SC) is the skin's outermost layer and serves the primary function of acting as a shield to keep foreign matter out and to essential elements, such as moisture and water, in. Maintenance of this skin barrier is crucial to healthy functioning skin. A damaged or diseased skin barrier is vulnerable to infection, irritants, and allergens. The cornerstone of skin barrier regulation and repair is through the use of moisturizers. While healthcare providers and patients may underestimate the importance of moisturizers due to their lack of active ingredients, the benefit of a well-planned moisturizer regimen for skin barrier regulation should not be discounted...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28074749/students-use-stamp-out-program-to-advance-seniors-knowledge-of-drug-misuse
#17
Gabrielle Cozzi, Elisa Torres, Robert G Wahler
: This program assessed the impact of student presentations on 30 seniors and sought to improve their knowledge of prescription drug misuse and abuse. The six pharmacy students used the ASCP Foundation's "STAMP Out Prescription Drug Misuse and Abuse Tool Kit." Information presented to senior audiences included descriptions of drug misuse and abuse and preventive measures to uphold medication safety. Students assessed seniors' prior knowledge about the topics through audience participation...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28073934/the-influence-of-customer-medicine-seller-transactional-dynamics-on-childhood-diarrhoea-management-a-qualitative-study-in-ghana
#18
Lauren Rosapep, Emily Sanders, Kathryn Banke
In 2004, the World Health Organization (WHO) and United Nations Children's Fund (UNICEF) jointly revised the recommended treatment for acute paediatric diarrhoea to specify supplementing reduced osmolarity oral rehydration salts (ORS) with zinc. In many countries, however, a significant knowledge-practice gap persists in appropriate diarrhoea management among private healthcare providers. For example, the United States Agency for International Development (USAID)-funded Strengthening Health Outcomes through the Private Sector (SHOPS) project recently demonstrated that over-the-counter medicine sellers (MS) in Ghana recommended inappropriate diarrhoea treatments, despite their demonstrated knowledge of appropriate treatment protocols...
January 10, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28066116/perception-of-pharmacists-regarding-over-the-counter-medication-a-survey
#19
Abinaya Ravichandran, Asha Basavareddy
OBJECTIVE: To assess knowledge, attitude, and practice of the pharmacists toward dispensing the over-the-counter (OTC) medications using questionnaire. MATERIALS AND METHODS: cross-sectional questionnaire-based study was conducted to assess the knowledge, attitude, and practice among pharmacists regarding OTC medications. Eighty out of hundred filled questionnaires were received from various pharmacists from medical shops in and around Kolar. Data were analyzed using descriptive statistics...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28064105/a-brief-review-on-the-application-of-nanoparticle-enclosed-herbal-medicine-for-the-treatment-of-infective-endocarditis
#20
REVIEW
Mehrdad Namdari, Ali Eatemadi, Maryam Soleimaninejad, Aiyelabegan T Hammed
Herbal medicines have been routinely employed all over the world dated back from the ancient time and have been identified by patients and physicians for their excellent therapeutic value as they have lower adverse effects when compared with the modern medicines. Phytotherapeutics requires a scientific technique to deliver the active herbal extract in a controlled manner to avoid repeated administration and increase patient compliance. This can be reached by fabricating a novel drug delivery systems (NDDS) for herbal components...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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