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https://www.readbyqxmd.com/read/27933489/patients-understanding-and-use-of-analgesia-for-postnatal-pain-following-hospital-discharge
#1
Antonia M W Wong, Syed Tabish R Zaidi
Background Postnatal pain is one of the limiting factors in the recovery of women from child birth. Despite the routine prescribing of analgesics for postnatal pain, limited research is available on the use of analgesics by the women in postnatal period. Objective To measure the utilisation and effectiveness of prescribed oral analgesics, the incidence and severity of pain, and factors associated with poor pain control on the fifth-day post-hospital discharge in postnatal women. Setting A tertiary referral women's hospital of Western Australia...
December 9, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27925709/estimation-of-dietary-supplements-intake-in-a-selected-group-of-women-over-50-and-the-risk-assessment-of-interactions-between-the-ingredients-of-dietary-supplements-and-drugs
#2
Joanna Sadowska, Magda Bruszkowska
Background: Concurrent use of dietary supplements and drugs may result in complications of pharmacotherapy due to possible interactions between their ingredients. Objectives: The aim of the survey was to estimate the intake of dietary supplements in a group of women over 50 and to analyse the risk of interactions between the ingredients of dietary supplements and drugs taken by the women. Material and Methods: The study was carried out among 146 women over 50 years of age...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27925348/factors-associated-with-efficacy-of-an-ibuprofen-pseudoephedrine-combination-drug-in-pharmacy-customers%C3%A2-with-common-cold-symptoms
#3
Ludger Klimek, Helmut Schumacher, Tanja Schütt, Heidemarie Gräter, Tobias Mueck, Martin C Michel
AIM: The aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over-the-counter ibuprofen/pseudoephedrine combination product. METHODS: Data from an anonymous survey among 1770 pharmacy customers purchasing the combination product for treatment of own common cold symptoms underwent post-hoc descriptive analysis. Scores of symptoms typically responsive to ibuprofen (headache, pharyngeal pain, joint pain and fever), typically responsive to pseudoephedrine (congested nose, congested sinus and runny nose), considered non-specific (sneezing, fatigue, dry cough, cough with expectoration) and comprising all 11 symptoms were analysed...
December 7, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27918873/loperamide-the-poor-man-s-methadone-brief-review
#4
Cornel N Stanciu, Samantha A Gnanasegaram
Loperamide is widely available as an inexpensive, over-the-counter remedy commonly used for management of diarrhea. Although an opioid, at therapeutic doses it acts primarily on the gastrointestinal tissues; however, larger than recommended amounts facilitate central nervous system (CNS) penetration. Such high doses of loperamide have recently gained popularity among users of opioids to manage withdrawal symptomatology and, less frequently, to achieve psychoactive effects. Chronic loperamide use can result in development of tolerance and, upon abrupt cessation of use, withdrawal...
December 5, 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27913785/safety-assessment-of-alumina-and-aluminum-hydroxide-as-used-in-cosmetics
#5
Lillian C Becker, Ivan Boyer, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
This is a safety assessment of alumina and aluminum hydroxide as used in cosmetics. Alumina functions as an abrasive, absorbent, anticaking agent, bulking agent, and opacifying agent. Aluminum hydroxide functions as a buffering agent, corrosion inhibitor, and pH adjuster. The Food and Drug Administration (FDA) evaluated the safe use of alumina in several medical devices and aluminum hydroxide in over-the-counter drugs, which included a review of human and animal safety data. The Cosmetic Ingredient Review (CIR) Expert Panel considered the FDA evaluations as part of the basis for determining the safety of these ingredients as used in cosmetics...
November 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/27906534/food-and-drug-administration-review-and-action-on-over-the-counter-time-and-extent-applications-final-rule
#6
(no author information available yet)
The Food and Drug Administration (FDA or Agency) is amending its nonprescription (over-the-counter or OTC) drug regulations. This final rule supplements the time and extent application (TEA) process for OTC drugs by establishing timelines and performance metrics for FDA's review of non-sunscreen TEAs, as required by the Sunscreen Innovation Act (SIA). It also amends the existing TEA process to include filing determination and withdrawal provisions to make the TEA process more efficient.
November 23, 2016: Federal Register
https://www.readbyqxmd.com/read/27901207/in-vitro-and-in-vivo-evaluation-of-nano-based-films-for-buccal-delivery-of-zolpidem
#7
Bandar Essa Al-Dhubiab
Insomnia is becoming increasingly prevalent in the world general population. Therapies used by patients include over-the-counter therapies, herbal and dietary supplements, and pharmacological or nonpharmacological treatments. Among these, zolpidem is a pharmacological treatment popularly used for insomnia. Zolpidem is well tolerated and especially efficacious for initiation of sleep, and therefore is effective for the treatment of sleep-onset insomnia. The purpose of the present study was to design and evaluate zolpidem nanoparticle-impregnated buccal films to prolong the duration of its action...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27900921/-a-fixed-drug-eruption-caused-by-paracetamol
#8
L van Zogchel, T Hendriks, S Adriaens, I Diederen, E Herremans
BACKGROUND: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1.5% of cases. CASE DESCRIPTION: A 58-year-old man was seen in general practice with a five-year-old exanthema on his torso, arms and legs...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27896497/the-slippery-difficulty-of-ever-containing-drug-resistance-with-current-practices
#9
REVIEW
R Fullybright
It has previously been shown that the rate of drug resistance emergence in medicine is exponential, while we have been producing drugs at a much lower rate. Our ability to successfully contain resistance at any one time is function of how many drugs we have at our disposal to counter new resistances from pathogens. Here, we assess our level of preparedness through a mathematical comparison of the drug manufacture rate by the pharmaceutical industry with the resistance emergence rate in pathogens. To that effect, changes in the rates of growth of the drugs production and resistance emergence processes are computed over multiple time segments and compared...
November 28, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27891455/unmasking-the-effect-of-analgesics-on-endodontic-diagnosis-using-a-novel-bite-force-sensor-device-a-prospective-randomized-clinical-trial
#10
Sushil Kishnani, Suparna Ganguly Saha, Anuj Bhardwaj, Sandeep Dubey, Mainak Saha, Shubham Kala, Sohini Jain, Shweta Narwani
INTRODUCTION: A definitive diagnosis is of primary importance before initiating any endodontic treatment; yet, there are occasions when the dental professional is unable to accurately reproduce the patient's chief complaint, as it can pose a dilemma and may require consideration of multiple variables in order to reach an accurate diagnosis. So to overcome this problem, a methodical approach in providing endodontic treatment should be implemented which includes diagnosis, definitive dental treatment and adjunctive drug therapy, known as the "3D" strategy...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27881100/high-prevalence-of-non-steroidal-anti-inflammatory-drug-use-among-acute-kidney-injury-survivors-in-the-southern-community-cohort-study
#11
Loren Lipworth, Khaled Abdel-Kader, Jennifer Morse, Thomas G Stewart, Edmond K Kabagambe, Sharidan K Parr, Kelly A Birdwell, Michael E Matheny, Adriana M Hung, William J Blot, T Alp Ikizler, Edward D Siew
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and have been linked to acute kidney injury (AKI), chronic kidney disease (CKD) and cardiovascular disease (CVD). Patients who survive an AKI episode are at risk for future adverse kidney and cardiovascular outcomes. The objective of our study was to examine the prevalence and predictors of NSAID use among AKI survivors. METHODS: The Southern Community Cohort Study is a prospective study of low-income adults aged 40-79 in the southeastern US...
November 24, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27875056/opioid-nsaid-and-otc-analgesic-medications-for-dental-procedures-pearl-network-findings
#12
Ying Jo Wong, James Keenan, Keith Hudson, Henry Bryan, Frederick Naftolin, Van P Thompson, Ronald G Craig, Don Vena, Damon Collie, Hongyu Wu, Abigail G Matthews, Ashley C Grill, Frederick A Curro
OBJECTIVE: Dental treatment is often categorized as a moderately or severely painful experience; however, no clinical data reported by the patient and dentist currently exists to support this degree of pain. This has contributed possibly to the overprescribing of analgesics, in particular the opioid class of medications. The primary objective of the study was to document the dentists' postprocedural prescriptions and recommendations for analgesic medications and their effectiveness for a 5-day period...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27865294/overuse-and-misperceptions-of-nonsteroidal-anti-inflammatory-drugs-in-the-united-states
#13
Byron Cryer, Michael A Barnett, Jennifer Wagner, C Mel Wilcox
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most commonly used medications worldwide. The availability of hundreds of products containing an NSAID, combined with a lack of recognition and understanding of NSAIDs, can increase the potential of consumers to inadvertently exceed the recommended NSAID dosage, which can cause potentially serious side effects. Physician and consumer education regarding the appropriate use of NSAIDs can help prevent NSAID misuse...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27849273/use-of-prescription-drugs-and-self-medication-among-men
#14
Maria Aparecida Medeiros Barros do Prado, Priscila Maria Stolses Bergamo Francisco, Tássia Fraga Bastos, Marilisa Berti de Azevedo Barros
Objective: To estimate the prevalence, investigate factors associated with the use of medication according to prescription, identify the main pharmaceuticals consumed through self-medication, and the reason for this use among adult men. Methods: This cross-sectional population-based study with stratified clustered two-stage sampling was conducted in Campinas, São Paulo, Brazil, in 2008/2009. Results: Of the 1,063 men, 45.3% reported using at least 1 drug in the last 3 days...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27847132/weight-loss-drugs-and-lifestyle-modification-perceptions-among-a-diverse-adult-sample
#15
S Xing, L K Sharp, D R Touchette
OBJECTIVES: Explore how adults from diverse racial and socioeconomic backgrounds perceive the use of weight loss drugs (prescription, over-the counter, herbals and supplements) and lifestyle modification. METHODS: Individual, face-to-face, semi-structured interviews were conducted with persons presenting to an academic hospital-affiliated outpatient pharmacy serving ethnic minorities and low income individuals. RESULTS: Fifty persons were interviewed, including 21 African Americans, 11 Hispanics and 17 low-income individuals (annual income <$20,000), of whom 33 self-reported as overweight or obese...
November 9, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27843108/pharmacist-intervention-in-patient-selection-of-nonprescription-and-self-care-products
#16
John Taylor Schimmelfing, Andrea L Brookhart, K Michele Brown Fountain, Jean-Venable Kelly R Goode
OBJECTIVES: To evaluate the potential outcomes of pharmacist intervention on patient selection of nonprescription and self-care products and to evaluate patient confidence and satisfaction with the assistance of the pharmacist. METHODS: A prospective, convenience sample study was conducted at 3 locations of a national supermarket chain pharmacy in the Charlottesville, Virginia, area over 4 months. Patients were recruited for the study if they approached the pharmacy counter and requested assistance with nonprescription and self-care product selection or if the investigating pharmacists approached the patient in the self-care aisles...
November 10, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27842792/drug-toxicities-of-common-analgesic-medications-in-the-emergency-department
#17
REVIEW
Mateusz Ciejka, Khoa Nguyen, Martin H Bluth, Elizabeth Dubey
About 75% of patients present to the emergency department with a complaint of pain. There are multiple prescribed and over-the-counter medications that are available for the treatment of pain. Acetaminophen, opioids, and aspirin are commonly used agents that are available as single agents or in combination with other medications. However, all of these agents are susceptible to toxic overdose, which requires prompt recognition through clinical and laboratory assessment modalities and initiation of therapy to reduce the risk of morbidity and mortality...
December 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27842538/the-modified-gingyo-san-a-chinese-herbal-medicine-has-direct-antibacterial-effects-against-respiratory-pathogens
#18
Tetsuya Yamada, Takeaki Wajima, Hidemasa Nakaminami, Kaho Kobayashi, Hideaki Ikoshi, Norihisa Noguchi
BACKGROUND: Modified Gingyo-san (MGS) is empirically used to treat various respiratory infections. MGS has been reported to have antiinflammatory and antiviral activities; however, it is not known if it has an antibacterial activity. Therefore, in this study, we aimed to investigate the antimicrobial activity of MGS against respiratory pathogens. METHODS: MGS, which is sold as an over-the-counter drug in Japan, was used for the study. Antimicrobial activity was evaluated using the disk diffusion method...
November 14, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27842443/clinical-update-on-benefit-versus-risks-of-oral-paracetamol-alone-or-with-codeine-still-a-good-option
#19
Hans Georg Kress, Gerald Untersteiner
BACKGROUND: After decades of worldwide use of paracetamol/acetaminophen as a popular and apparently safe prescription and over-the-counter medicine, the future role of this poorly understood analgesic has been seriously questioned by recent concerns about prenatal, cardiovascular (CV) and hepatic safety, and also about its analgesic efficacy. At the same time the usefulness of codeine in combination products has come under debate. METHODS: Based on a PubMed database literature search on the terms efficacy, safety, paracetamol, acetaminophen, codeine and their combinations up to and including June 2016, this clinical update reviews the current evidence of the benefit and risks of oral paracetamol alone and with codeine for mild-to-moderate pain in adults, and compares the respective efficacy and safety profiles with those of nonsteroidal anti-inflammatory drugs (NSAIDs)...
November 15, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27832658/anaphylaxis-to-over-the-counter-flurbiprofen-in-a-child
#20
Mattia Giovannini, Lucrezia Sarti, Simona Barni, Neri Pucci, Elio Novembre, Francesca Mori
Non-steroidal anti-inflammatory drugs are suspected to cause drug hypersensitivity very frequently in paediatric patients. In this article, we describe the first case of anaphylaxis to flurbiprofen in a child and provide insight into the possibility of severe reactions and even anaphylaxis to over-the-counter flurbiprofen. Finally, the importance of a rigorous allergy work-up in reaching a confident diagnosis and providing the patient with a safe alternative is shown.
November 11, 2016: Pharmacology
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