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https://www.readbyqxmd.com/read/28442191/barriers-to-single-dose-levonorgestrel-only-emergency-contraception-access-in-retail-pharmacies
#1
Van Mimi Chau, Carol A Stamm, Laura Borgelt, Michelle Gaffaney, Alia Moore, Rachel Z Blumhagen, Leanne Rupp, Daniel Topp, Christine Gilroy
OBJECTIVES: In February 2014, the Food and Drug Administration updated its regulations to make all single-dose levonorgestrel-only emergency contraception (LNG-EC) available over the counter. This study examines the availability and access to LNG-EC shortly after this policy change, and any additional barriers to obtaining LNG-EC in Colorado retail pharmacies. STUDY DESIGN: From June to July 2014, three female interviewers posing as women seeking LNG-EC conducted a telephone survey of all 633 Colorado retail pharmacies listed in The Little Blue Book (2014) phone directory...
April 23, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28416070/-intentional-suicide-with-cyclizine
#2
Nikolaj Preus Hatting, Peter Martin Hansen
Cyclizine is an antihistamine with a sedative effect. In Denmark it is an over-the-counter drug, whereas it is a prescription drug in many other countries. It possesses anticholinergic and antiemetic properties, although the exact mechanism of action is unknown. At doses greater than 5 mg/kg potent side effects of anticholinergic character can be expected. This case report is a description of an intentional suicide with a dose greater than 70 mg/kg.
April 3, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28402415/single-versus-repeat-doses-of-misoprostol-for-treatment-of-early-pregnancy-loss-a-randomized-clinical-trial
#3
Yossi Mizrachi, Ann Dekalo, Ohad Gluck, Hadas Miremberg, Lotem Dafna, Ohad Feldstein, Eran Weiner, Jacob Bar, Ron Sagiv
STUDY QUESTION: Does repeat administration of misoprostol for early pregnancy loss increase the treatment success rate? SUMMARY ANSWER: Repeat administration of misoprostol does not increase the treatment success rate, and is associated with more analgesics use. WHAT IS KNOWN ALREADY: Misoprostol reduces the need for surgical evacuation and shortens the time to complete expulsion in patients with early pregnancy loss. However, the impact of repeat doses of misoprostol is not clear...
April 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28399319/factors-associated-with-potentially-inappropriate-medication-use-in-rural-community-dwelling-older-adults
#4
Marcia Y Shade, Ann M Berger, Claudia Chaperon, Gleb Haynatzki, Linda Sobeski, Bernice Yates
Potentially inappropriate medication (PIM) use is a serious public health problem in older adults because it may lead to adverse events. The purpose of the current study was to explore PIM use in rural, community-dwelling older adults. Participants (N = 138) underwent one-on-one medication reviews. Approximately one half (49%) of the sample used prescribed and over-the-counter (OTC) PIM. Prescribed and OTC nonsteroidal anti-inflammatory drugs (33%) and anticholinergic medications (28%) were the most frequently used PIM...
April 11, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28398023/clinical-profile-of-women-with-vva-who-are-not-candidates-for-local-vaginal-oestrogen-therapy
#5
Rossella E Nappi, Filippo Murina, Giuseppina Perrone, Paola Villa, Nicoletta Biglia
Vulvar and vaginal atrophy (VVA) is a chronic medical condition in postmenopausal women, which is predominantly due to a permanent cessation of ovarian oestrogen production. Current available treatment options for VVA are over-the-counter (OTC) symptomatic relief products or local oestrogen therapy (LET) aiming to treat this underlying atrophic condition. Recent surveys indicated that these products decrease sexual spontaneity, are messy and indiscrete. Ospemifene is an oral daily drug, which has proven to treat vaginal dryness and dyspareunia effectively...
April 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28391495/boric-acid-inhibition-of-trichophyton-rubrum-growth-and-conidia-formation
#6
Martin Schmidt
Trichophyton rubrum is a common human dermatophyte that is the causative agent of 80-93% of fungal infections of the skin and nails. While dermatophyte infections in healthy people are easily treatable with over-the-counter medications, such infections pose a higher risk for patients with compromised immune function and impaired regenerative potential. The efficacy of boric acid (BA) for the treatment of vaginal yeast infections prompted an investigation of the effect of BA on growth and morphology of T. rubrum...
April 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28381856/buying-over-the-counter-antacid-products-containing-aspirin-fda-drug-safety-communication-for-serious-bleeding-risk
#7
Kiran Kumar Boyina, Gayatri Nakkana, V Venkata Ramana Murthy
No abstract text is available yet for this article.
April 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28379496/codeine-use-dependence-and-help-seeking-behaviour-in-the-uk-and-ireland-an-online-cross-sectional-survey
#8
Andreas Kimergård, Michelle Foley, Zoe Davey, Jacklyn Dunne, Colin Drummond, Paolo Deluca
Background: Codeine misuse and dependence poses a clinical and public health challenge. However, little is known about dependence and treatment needs in the UK and Ireland. Aim: To characterise codeine use, dependence, and help-seeking behaviour. Design: An online cross-sectional survey advertised on Facebook, Twitter, health and drug websites and e-mail circulars. Methods: The survey collected data on demographics and codeine use amongst adults from the UK and Ireland...
April 3, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28375418/unexpected-serious-cardiac-arrhythmias-in-the-setting-of-loperamide-abuse
#9
Somwail Rasla, Amy St Amand, Marina K Garas, Amr El Meligy, Taro Minami
Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea. When ingested in excessive doses, loperamide can penetrate the blood-brain barrier and is reported to produce euphoria, central nervous system and respiratory depression, and cardiotoxicity. There is an emerging trend in its use among drug abusers for its euphoric effects or for self-treatment of opioid withdrawal. We report a case of ventricular dysrhythmias associated with loperamide abuse in a 28-year-old man who substituted loperamide for the opioids that he used to abuse...
April 3, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28375409/hot-topics-in-primary-care-the-cardiovascular-safety-of-nonsteroidal-anti-inflammatory-drugs-putting-the-evidence-in-perspective
#10
REVIEW
Martin Quan
The Vioxx Gastrointestinal Outcomes Research (VIGOR) trial, published in 2000, was the first to raise concerns that NSAIDs (specifically, the COX-2 selective inhibitor rofecoxib) might be associated with a higher risk for cardiovascular (CV) events. As discussed in this article, subsequent trials and meta-analyses have demonstrated a higher CV risk with use of not only COX-2 inhibitors (coxibs) but also certain tNSAIDs. These investigations have contributed to actions by the US Food and Drug Administration (FDA), most recently in July 2015, requiring strengthening of CV risk warnings on labels for all prescription and over-the-counter NSAIDs, despite evidence suggesting that differences in CV risk may exist among the NSAIDs...
April 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28370717/e-cigarette-use-of-young-adults-motivations-and-associations-with-combustible-cigarette-alcohol-marijuana-and-other-illicit-drugs
#11
Jeff R Temple, Ryan C Shorey, Yu Lu, Elizabeth Torres, Gregory L Stuart, Vi D Le
BACKGROUND AND OBJECTIVES: Although the prevalence of e-cigarette use among adolescents and young adults has caught up to or eclipsed that of combustible cigarette use, there is relatively little known about (a) the link between e-cigarettes and other substances and (b) the reasons underlying this increase in e-cigarette use. To address this gap in knowledge, the current study examined associations between e-cigarette use and other substances and identified motives for e-cigarette use among young adults...
March 31, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28369729/recent-literature-update-on-medication-risk-in-older-adults-2015-2016
#12
Michael J Koronkowski, Todd P Semla, Kenneth E Schmader, Joseph T Hanlon
Medications can pose considerable risk in older adults. This article annotates four articles addressing this concern from 2016. The first provides national data on the use of specific prescription, over-the-counter and dietary supplements in older adults and their change over time. The second discusses the opportunity of deprescribing ineffective/unnecessary stool softeners (i.e., docusate) routinely given to older hospital patients. The third national study examines common adverse drug events in older emergency room patients...
March 28, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28364318/reassessing-the-ecology-of-medical-care-in-japan
#13
Tsuguya Fukui, Mahbubur Rahman, Sachiko Ohde, Eri Hoshino, Takeshi Kimura, Kevin Y Urayama, Fumio Omata, Gautam A Deshpande, Osamu Takahashi
Studies on ecology of medical care can provide valuable information on how people seek healthcare in a specific geographic area. The objective of this study was to update a 2003 report on the ecology of medical care in Japan, identifying relevant changes in healthcare patterns. We collected information based on a prospective health diary recorded for a month in 2013 (n = 4548; 3787 adults and 797 children) using a population-weighted random sample from a nationally representative panel. We compared our overall and stratified findings with a similar study conducted in 2003...
March 31, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28358386/lack-of-pregnancy-warnings-on-over-the-counter-dermatologic-products-containing-potentially-harmful-hydroquinone
#14
L L Bio, J J Cies
OBJECTIVE: To determine the presence of pregnancy warnings on over-the-counter (OTC) dermatologic products with hydroquinone, a potentially harmful ingredient. STUDY DESIGN: Data were obtained from the Food and Drug Administration National Drug Code Directory and Label Repository to identify OTC dermatologic products containing hydroquinone. Products were stratified based on pregnancy or general warning presence (WP) or absence (WA). Product characteristics were compared between groups: hydroquinone concentration, presence of external packaging, indication and warning statements...
March 30, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28352949/from-prescription-only-rx-to-over-the-counter-otc-status-in-germany-2006-2015-pharmacological-perspectives-on-regulatory-decisions
#15
Eva Barrenberg, Edeltraut Garbe
PURPOSE: Little is known about the extent of switches from prescription-only (Rx) to over-the-counter (OTC) status in Europe and about the pharmacological properties of the switched substances. The objectives of this study were to provide an overview of the substances that were switched from Rx to OTC status in Germany between 2006 and 2015 and to assess their pharmacological properties. METHODS: Session minutes of the German Expert Advisory Committee for Prescription-Only Issues, changes to the German Ordinance on Prescription-Only Medicines and the Summary of Product Characteristics of the switched substances were analysed...
March 28, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28349341/knowledge-and-opinion-of-pharmacists-on-emergency-contraceptive-pills-in-hungary
#16
Melinda Vanya, Maria Matuz, Ria Benko, Reka Viola, Attila Horvath-Sziklai, Gyongyvér Soos, Gyorgy Bartfai
Background Emergency contraceptive pills (ECPs) are used to prevent unintended pregnancy. There is a worldwide intention to improve access to ECPs; therefore, identifying potential barriers to introducing over-the counter (OTC) access is of utmost importance. As pharmacists are the key personnel to convey accurate drug information, their knowledge and attitude on ECPs is important. Objective We aimed to conduct a nationwide study to assess pharmacists' knowledge on ECPs and to survey their opinion on sales category change of ECPs (i...
March 27, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28348936/ciprofloxacin-induced-hepatotoxicity-in-a-healthy-young-adult
#17
Zulfiqar Qutrio Baloch, Muhammad Ali Raza, Shabber A Abbas, Sumera Bukhari
Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic that is widely used in the treatment of many common infections, including urinary tract infections (UTIs). Despite the increase in Escherichia coli resistance to ciprofloxacin, especially in the United States (US), clinicians continue to utilize the high bioavailability of this drug in urine to counter UTIs. A rare adverse effect following use of ciprofloxacin is drug-induced hepatitis. In this case report, we describe a young 29-year-old female with a previous medical history significant for pyelonephritis and ovarian cyst who presented to the emergency room with signs and symptoms suggestive of progressive liver injury for two weeks that started two days after a complete course of ciprofloxacin therapy for a UTI...
February 8, 2017: Curēus
https://www.readbyqxmd.com/read/28345245/pain-depressive-symptoms-and-medication-in-german-patients-with-rheumatoid-arthritis-results-from-the-linking-patient-reported-outcomes-with-claims-data-for-health-services-research-in-rheumatology-proclair-study
#18
Kathrin Jobski, Andres Luque Ramos, Katinka Albrecht, Falk Hoffmann
PURPOSE: Pain and depressive symptoms are common in patients with rheumatoid arthritis (RA). Information on the prevalence and treatment of both conditions in German RA patients is scarce. METHODS: Using data from a nationwide statutory health insurance fund (BARMER GEK), 6193 RA patients aged 18 to 79 years were provided with a questionnaire covering a variety of items such as demographics, medical condition and quality of life in 2015. Pain caused by the joint disorder (11-point scale) was classified as none existent/mild, moderate or severe...
March 26, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28344968/pulmonary-embolism-in-a-healthy-woman-using-the-oral-contraceptives-containing-desogestrel
#19
Min-Jeong Park, Gyun-Ho Jeon
Venous thromboembolism is well known as one of the rare but serious adverse effects of combined oral contraceptives (COCs). The COCs with third and fourth generation progestogens were found to have higher risk of venous thrombosis than those with second generation progestogens. We present a case of pulmonary embolism in a 23-year-old nulligravid woman who was using COCs containing the third generation progestogen (desogestrel). At the time of presentation of the adverse effect, she had been using the COCs for 4 months...
March 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28339586/framing-tobacco-dependence-as-a-brain-disease-implications-for-policy-and-practice
#20
Kylie Morphett, Adrian Carter, Wayne Hall, Coral Gartner
Introduction: Like other forms of drug dependence, tobacco dependence is increasingly being described as a "chronic brain disease." The potential consequences of this medical labelling have been examined in relation to other addictions, but the implications for tobacco control have been neglected. Some have posited that biomedical conceptions of addiction will reduce stigma and increase uptake of efficacious treatments. Others have countered that it could increase stigma, reduce treatment seeking, and deter unassisted quitting...
January 21, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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