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https://www.readbyqxmd.com/read/29149894/comments-on-incidence-of-cancer-among-licensed-commercial-pilots-flying-north-atlantic-routes
#1
EDITORIAL
S M J Mortazavi
Gudmundsdottir et al. in their paper entitled "Incidence of cancer among licensed commercial pilots flying North Atlantic routes" published in Environmental Health have evaluated the effects of exposure to higher levels of cosmic radiation on cancer incidence in the pilots of commercial flights. Despite its remarkable strengths, the paper authored by Gudmundsdottir et al. has some shortcomings. The shortcomings of this paper such as not determining the shape of dose-response relationship for radiation-induced cancers, limitations in flight dose calculations, the weaknesses of CARI-6 as the program used by Gudmundsdottir et al...
November 17, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29149586/scholarly-merits-from-measurement-to-judgment
#2
Joachim Funke
The discussion in Perspectives on Psychological Science about criteria for scholarly merit shows a potential bias of quantitative measurements compared with informed judgments of scholarly merits. This comment argues for a selection procedure that is open for qualitative arguments.
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29149350/a-data-fusion-pipeline-for-generating-and-enriching-adverse-outcome-pathway-descriptions
#3
Penny Nymark, Linda Rieswijk, Friederike Ehrhart, Nina Jeliazkova, Georgia Tsiliki, Haralambos Sarimveis, Chris T Evelo, Vesa Hongisto, Pekka Kohonen, Egon Willighagen, Roland C Grafström
Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and informatics-tool supported pipeline schemas for fitting such data into Adverse Outcome Pathway (AOP) descriptions could potentially aid the development of non-animal based hazard and risk assessment methods. We devised a six-step workflow that integrated diverse types of toxicology data into a novel AOP scheme for pulmonary fibrosis. Mining of literature references and diverse data sources covering previous pathway descriptions and molecular results were coupled in a stepwise manner with informatics tools applications that enabled gene linkage and pathway identification in molecular interaction maps...
November 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29149262/a-food-environments-feedback-system-foodback-for-empowering-citizens-and-change-agents-to-create-healthier-community-food-places
#4
Stefanie Vandevijvere, Rachel Williams, Essa Tawfiq, Boyd Swinburn
This study developed a systems-based approach (called FoodBack) to empower citizens and change agents to create healthier community food places. Formative evaluations were held with citizens and change agents in six diverse New Zealand communities, supplemented by semi-structured interviews with 85 change agents in Auckland and Hamilton in 2015-2016. The emerging system was additionally reviewed by public health experts from diverse organizations. A food environments feedback system was constructed to crowdsource key indicators of the healthiness of diverse community food places (i...
November 14, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29149108/comment-on-efficacy-of-stereotactic-body-radiotherapy-in-oligorecurrent-and-in-oligoprogressive-prostate-cancer-new-evidence-from-a-multicentric-study
#5
Isabel Bravo
No abstract text is available yet for this article.
November 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29149106/reply-to-comment-on-efficacy-of-stereotactic-body-radiotherapy-in-oligorecurrent-and-in-oligoprogressive-prostate-cancer-new-evidence-from-a-multicentric-study
#6
Luca Triggiani, Rosario Mazzola, Stefano Maria Magrini, Filippo Alongi, Michela Buglione
No abstract text is available yet for this article.
November 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29148631/retracted-silencing-of-the-cops3-gene-by-sirna-reduces-proliferation-of-lung-cancer-cells-most-likely-via-induction-of-cell-cycle-arrest-and-apoptosis
#7
(no author information available yet)
Retraction: Retracted: siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells Asian Pacific Journal of Cancer Prevention has retracted the article titled “siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells”(1) for reason of similarity with a series of articles identified by Byrne and Labbé (2). 1. Huang WY1, Chen DH, Ning L, Wang LW. siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells...
November 17, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29148278/-her-choice-of-course-negotiating-legitimacy-of-choice-in-abortion-rights-deliberations-during-the-repeal-the-eighth-movement-in-ireland
#8
Rahul Sambaraju, Myles Sammon, Frank Harnett, Emma Douglas
Discourses of 'choice' are routinely involved in sexual and reproductive rights' advocacy. In this article, we offer a discursive psychological examination of how 'choice' is oriented to, in online deliberations on the ongoing movement for abortion rights in Ireland. Comment posters treated 'choice' as involving outcomes of and motives for choosing, in negotiating legitimacy of women's rights to choose. These accompanied alternative versions of women, either as independent or as intimately bound up with pregnancy/motherhood, which were flexibly used in negotiation legitimacy of women's rights to 'choice' in abortion practices...
November 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29148154/incident-reporting-behaviours-following-the-francis-report-a-cross-sectional-survey
#9
Gareth Archer, Alison Colhoun
RATIONALE, AIMS, AND OBJECTIVES: Previous studies have shown a lack of engagement in the reporting process. There is limited evidence about whether attitudes and behaviours of doctors in the UK towards incident reporting have changed following the events at Mid Staffordshire National Health Service Foundation Trust and the recommendations that followed. We conducted a relatively large survey of doctors, aiming to assess whether doctors recognised incidents and reported them accordingly, along with their behaviours towards reporting and their suggestions of how incident reporting may be improved...
November 17, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29147996/comments-on-a-stripping-method-to-remove-stuck-catheter-and-a-plea-to-adopt-large-size-hemodialysis-catheters
#10
Joon Ho Hong
No abstract text is available yet for this article.
November 11, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29147101/characteristics-of-kwark-cheese-supplemented-with-bifidobacterium-longum-kacc-91563
#11
Minyu Song, Won Seo Park, Jayeon Yoo, Gi-Sung Han, Bu-Min Kim, Pil-Nam Seong, Mi-Hwa Oh, Kyung-Woon Kim, Jun-Sang Ham
The effect of addition of the probiotic Bifidobacterium longum KACC 91563 on the chemical and sensory properties of Kwark cheese produced using CHN-11 as a cheese starter were investigated. The addition of B. longum KACC 91563 to Kwark cheese did not change the composition or pH value of the cheese, compared with control. B. longum KACC 91563 survived at a level of 7.58 Log CFU/g and did not have any negative effect on survival of the cheese starter. A sensory panel commented that the addition of B. longum KACC 91563 made Kwark cheese more desirable to consumers, and that the probiotic supplementation had no effect on perceived taste...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29146804/response-to-comment-on-the-extent-of-forest-in-dryland-biomes
#12
J-F Bastin, D Mollicone, A Grainger, B Sparrow, N Picard, A Lowe, R Castro
Griffith et al do not question the quality of our analysis, but they question our results with respect to the definition of forest we employed. In our response, we explain why the differences we report result from a difference of technique and not of definition, and how anyone can adapt-as we did-our data set to any forest definition and tree cover threshold of interest.
November 17, 2017: Science
https://www.readbyqxmd.com/read/29146777/comment-on-the-extent-of-forest-in-dryland-biomes
#13
Daniel M Griffith, Caroline E R Lehmann, Caroline A E Strömberg, Catherine L Parr, R Toby Pennington, Mahesh Sankaran, Jayashree Ratnam, Christopher J Still, Rebecca L Powell, Niall P Hanan, Jesse B Nippert, Colin P Osborne, Stephen P Good, T Michael Anderson, Ricardo M Holdo, Joseph W Veldman, Giselda Durigan, Kyle W Tomlinson, William A Hoffmann, Sally Archibald, William J Bond
Bastin et al (Reports, 12 May 2017, p. 635) infer forest as more globally extensive than previously estimated using tree cover data. However, their forest definition does not reflect ecosystem function or biotic composition. These structural and climatic definitions inflate forest estimates across the tropics and undermine conservation goals, leading to inappropriate management policies and practices in tropical grassy ecosystems.
November 17, 2017: Science
https://www.readbyqxmd.com/read/29146113/editorial-comment
#14
Alex Gomelsky
No abstract text is available yet for this article.
November 13, 2017: Urology
https://www.readbyqxmd.com/read/29145935/effectiveness-of-pharmacist-led-anticoagulation-management-on-clinical-outcomes-a-systematic-review-and-meta-analysis
#15
Kelu Hou, Hui Yang, Zhikang Ye, Ying Wang, Lihong Liu, Xiangli Cui
OBJECTIVES: We performed this systematic review and meta-analysis to confirm whether patients benefit more from pharmacist-led anticoagulation management than other models. METHODS: We searched PubMed, Embase, Cochrane Library and reference lists of yielded results conducted up to April 25, 2017. RCTs and observational cohort studies and case-control studies which compared the percentage of time within the target therapeutic range (TTR), the percentage of time within the expanded therapeutic range (TER), haemorrhage events, thrombosis events, mortality, patient satisfaction and/or medicine cost saving of pharmacist-led anticoagulation management with other models, and species were limited to humans...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145934/economic-evaluations-on-antimicrobial-stewardship-programme-a-systematic-review
#16
Nor Haizan Ibrahim, Khalidah Maruan, Hasryn Azzuar Mohd Khairy, Yet Hoi Hong, Ahmad Fauzi Dali, Chin Fen Neoh
PURPOSE: To systematically review studies on cost-effectiveness of implementing Antimicrobial stewardship programmes (ASP) in the hospital setting. METHODS: A systematic literature search was performed using electronic databases, such as EMBASE, PubMed/Medline, CINAHL, NHS and CEA Registry from 2000 until 2017. The quality of each included study was assessed using Joanna Briggs Institute Critical Appraisal Checklist for Economic Evaluations and Consolidated Health Economic Evaluation Reporting Standards Statement checklist...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145933/quantitative-structure-pharmacokinetics-relationships-for-plasma-protein-binding-of-basic-drugs
#17
Zvetanka Dobreva Zhivkova
PURPOSE: Binding of drugs to plasma proteins is a common physiological occurrence which may have a profound effect on both pharmacokinetics and pharmacodynamics. The early prediction of plasma protein binding (PPB) of new drug candidates is an important step in drug development process. The present study is focused on the development of quantitative structure - pharmacokinetics relationship (QSPkR) for the negative logarithm of the free fraction of the drug in plasma (pfu) of basic drugs...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145932/lipid-emulsion-more-than-reversing-bupivacaine-cardiotoxicity-potential-organ-protection
#18
Negar Motayagheni, Sheshanna Phan, Ala Nozari, Anthony Atala
Efforts to develop a treatment for bupivacaine cardiotoxicity led to the discovery that Intralipid, a popular brand of intravenous lipid emulsion, could be used not only as an effective treatment for anesthetic-induced cardiac arrest, but also as a means of reversing many other toxicities. Contradictory data exist regarding the mechanism of action of lipid emulsion, a combination of fatty acids traditionally used in parenteral nutrition. Some researchers attribute the effects to lipophilicity and the individual characteristics of the lipids, while other data demonstrate a direct empowering mechanism through cellular upstream and downstream pathways...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145931/in-vitro-and-in-silico-approaches-to-study-cytochrome-p450-mediated-interactions
#19
Boon Hooi Tan, Yan Pan, Amelia Nathania Dong, Chin Eng Ong
In vitro and in silico models of drug metabolism are utilized regularly in the drug research and development as tools for assessing pharmacokinetic variability and drug-drug interaction risk. The use of in vitro and in silico predictive approaches offers advantages including guiding rational design of clinical drug-drug interaction studies, minimization of human risk in the clinical trials, as well as cost and time savings due to lesser attrition during compound development process. This article gives a review of some of the current in vitro and in silico methods used to characterize cytochrome P450(CYP)-mediated drug metabolism for estimating pharmacokinetic variability and the magnitude of drug-drug interactions...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145930/assessment-of-predicted-rate-and-associated-factors-of-dabigatran-induced-bleeding-events-in-malaysian-patients-with-non-valvular-atrial-fibrillation
#20
Semira Abdi Beshir, Lok Bin Yap, Szyuin Sim, Kok Han Chee, Yoke Lin Lo
PURPOSE: To assess the predicted rate and the factors associated with bleeding events among patients with non-valvular atrial fibrillation (NVAF) receiving dabigatran therapy. METHODS: This retrospective cohort study includes adult patients of two tertiary hospitals in Malaysia. Potential study subjects were identified using pharmacy supply database or novel oral anticoagulant (NOAC) registry. Demographics, clinical data and laboratory test results were extracted from the medical records of the patients or electronic databases...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
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