Read by QxMD icon Read


Mousumi Pal, Utpal Nandi, Debaraj Mukherjee
Ruthenium (Ru) complexes are known for their promising anticancer activity presumably due to octahedral coordination geometry, slow ligand exchange rate, the range of different oxidation states and target specificity. This review article summarizes the physicochemical processes which are responsible for the selectivity of Ru complexes toward cancer cells over the normal cells. Emphasis has been given on the activation mechanism of Ru(III) complex administered as a prodrug and then the release of active species in an acidic environment of cancer cell through normal or photo induced hydrolysis or ligand oxidation...
March 7, 2018: European Journal of Medicinal Chemistry
Sabine Hoffmann, Chantal Guihenneuc, Sophie Ancelet
Exposure measurement error can be seen as one of the most important sources of uncertainty in studies in epidemiology. When the aim is to assess the effects of measurement error on statistical inference or to compare the performance of several methods for measurement error correction, it is indispensable to be able to generate different types of measurement error. This paper compares two approaches for the generation of Berkson error, which have recently been applied in radiation epidemiology, in their ability to generate exposure data that satisfy the properties of the Berkson model...
March 15, 2018: Radiation and Environmental Biophysics
Sabina Kedzierska-Mieszkowska, Joanna Renke
No abstract text is available yet for this article.
March 12, 2018: Journal of Clinical Endocrinology and Metabolism
Jonathan L Preston, Gabriela Holliman-Lopez, Megan C Leece
Purpose: Ultrasound visual feedback of the tongue is increasingly used as a component of speech therapy in clinical research and practice. The purpose is to offer a preliminary summary of the nature of participant-reported undesired effects related to ultrasound visual feedback. Method: Sixty-two participants across 3 sites (mean age = 11.9 years) and 38 parents responded to a 2-item verbal questionnaire following 14-16 hr of treatment regarding any aspects of the treatment they did not like...
March 15, 2018: American Journal of Speech-language Pathology
Manuel Delgado-Baquerizo, David J Eldridge, Fernando T Maestre, Senani B Karunaratne, Pankaj Trivedi, Peter B Reich, Brajesh K Singh
The technical comment from Sanderman provides a unique opportunity to deepen our understanding of the mechanisms explaining the role of paleoclimate in the contemporary distribution of global soil C content, as reported in our article. Sanderman argues that the role of paleoclimate in predicting soil C content might be accounted for by using slowly changing soil properties as predictors. This is a key point that we highlighted in the supplementary materials of our article, which demonstrated, to the degree possible given available data, that soil properties alone cannot account for the unique portion of the variation in soil C explained by paleoclimate...
March 2018: Science Advances
Jonathan Sanderman
Delgado-Baquerizo et al . ( Science Advances , 12 April 2017, e1602008) use statistical correlations to infer that paleoclimate (6000 to 22,000 years ago) is a more important driver of current soil organic carbon stocks than the current-day climate. On the other hand, a wealth of radiocarbon measurements indicates that the organic carbon in most topsoils is only a few decades to perhaps a few centuries old. These seemingly incongruous results can perhaps be reconciled by considering that the long-term pedogenic development of a soil strongly influences the physiochemical properties, which lead to stabilization of new carbon entering that soil regardless of current climate...
March 2018: Science Advances
J M Colley, M Harris, P Hellyer, D R Radford
Dentistry is recognised as a stressful profession. A number of studies focusing on undergraduate education have shown high levels of stress in dental students. However, despite calls to do so, little has been published on methods to teach future dental professionals about stress and how to manage it on a personal level. Psychological stress which is uncontrolled may have an effect on general health. It is recognised, however, that stress can be beneficial if channelled appropriately. Techniques and ways to teach management of potential stresses of a career in dentistry have still not been widely reported in either dental undergraduate or postgraduate education...
March 16, 2018: British Dental Journal
Robert S Svatek
No abstract text is available yet for this article.
March 12, 2018: Journal of Urology
Doreen E Chung
No abstract text is available yet for this article.
March 12, 2018: Journal of Urology
Donald L Lamm
No abstract text is available yet for this article.
March 12, 2018: Journal of Urology
Theodorus H van der Kwast
No abstract text is available yet for this article.
March 12, 2018: Journal of Urology
Alireza Aminsharifi, Thomas J Polascik
No abstract text is available yet for this article.
March 12, 2018: Journal of Urology
Gladys Witt Strain
No abstract text is available yet for this article.
February 14, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Robert Abouassaly
No abstract text is available yet for this article.
March 12, 2018: Urology
Mariana Matias, Samuel Silvestre, Amílcar Falcão, Gilberto Alves
Purpose - During the discovery and development of new drugs, compounds with low aqueous solubility pose special challenges in their pharmacological evaluation and, therefore, the selection of appropriate vehicles to administer the compounds of interest is determinant for the quality of the results generated during the in vivo non-clinical studies. This work aimed to evaluate the motor deficit (as a surrogate of neurotoxicity) of several administration/delivery vehicles through the rotarod performance test. Methods - Trained male CD-1 mice were intraperitoneally administered with the following vehicles: dimethyl sulfoxide (DMSO), aqueous sodium chloride (NaCl) 0...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Congyu Wu, Yajing Shen, Mengwei Chen, Kun Wang, Yongyong Li, Yu Cheng
Remote control of cells and the regulation of cell events at the molecular level are of great interest in the biomedical field. In addition to chemical compounds and genes, mechanical forces play a pivotal role in regulating cell fate, which have prompted the rapid growth of mechanobiology. From a perspective of nanotechnology, magnetic nanomaterials (MNs) are an appealing option for mechanotransduction due to their capabilities in spatiotemporal manipulation of mechanical forces via the magnetic field. As a newly developed paradigm, magneto-mechanotransduction is harnessed to physically regulate cell fate for biomedical applications...
March 15, 2018: Advanced Materials
M Brimioulle, A Al-Lami, S Marzouk, H Emerson, A Balfour, V Dhar, I J Nixon
Introduction The aim of this study was to determine whether ultrasound alone is sufficient to safely exclude malignancy in thyroid nodules in a district general hospital setting, to comply with the latest British Thyroid Association guidelines. Methods This retrospective study investigated the quality of ultrasound reporting and the correlation between ultrasound report and histology for individual thyroid nodules. Cases were selected from the thyroid multidisciplinary meeting and included all patients having undergone surgery for a thyroid malignancy in a one-year period...
March 15, 2018: Annals of the Royal College of Surgeons of England
Matthew Buican, Zoltan Laczko
In various dimensions, we can sometimes compute observables of interacting conformal field theories (CFTs) that are connected to free theories via the renormalization group (RG) flow by computing protected quantities in the free theories. On the other hand, in two dimensions, it is often possible to algebraically construct observables of interacting CFTs using free fields without the need to explicitly construct an underlying RG flow. In this Letter, we begin to extend this idea to higher dimensions by showing that one can compute certain observables of an infinite set of unitary strongly interacting four-dimensional N=2 superconformal field theories (SCFTs) by performing simple calculations involving sets of nonunitary free four-dimensional hypermultiplets...
February 23, 2018: Physical Review Letters
Troels Harmark, Matthias Wilhelm
We establish a framework for calculating the Hagedorn temperature of AdS_{5}/CFT_{4} via integrability. Concretely, we derive the thermodynamic Bethe ansatz equations that yield the Hagedorn temperature of planar N=4 super Yang-Mills theory at any value of the 't Hooft coupling. We solve these equations perturbatively at weak coupling via the associated Y system, confirming the known results at tree level and one-loop order as well as deriving the previously unknown two-loop Hagedorn temperature. Finally, we comment on solving the equations at finite coupling...
February 16, 2018: Physical Review Letters
Verónica Schiariti, Eileen Fowler, Joline E Brandenburg, Eric Levey, Sarah Mcintyre, Theresa Sukal-Moulton, Sharon L Ramey, Jessica Rose, Susan Sienko, Elaine Stashinko, Laura Vogtle, Robin S Feldman, James I Koenig
To increase the efficiency and effectiveness of clinical research studies, cerebral palsy (CP) specific Common Data Elements (CDEs) were developed through a partnership between the National Institute of Neurological Disorders and Stroke (NINDS) and the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM). International experts reviewed existing NINDS CDEs and tools used in studies of children and young people with CP. CDEs were compiled, subjected to internal review, and posted online for external public comment in September 2016...
March 15, 2018: Developmental Medicine and Child Neurology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"