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coronary artery spasm

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https://www.readbyqxmd.com/read/29776555/sudden-coronary-death-in-the-young-evidence-of-contractile-phenotype-of-smooth-muscle-cells-in-the-culprit-atherosclerotic-plaque
#1
Stefania Rizzo, Matteo Coen, Antonija Sakic, Monica De Gaspari, Gaetano Thiene, Giulio Gabbiani, Cristina Basso, Marie-Luce Bochaton-Piallat
BACKGROUND: Culprit coronary atherosclerotic plaques (APs) from young sudden cardiac death (SCD) victims are mostly non-atheromatous, i.e., consisting of proliferative smooth muscle cells (SMCs). Coronary vasospasm has been advocated to explain plaque instability in the absence of thrombosis. Our aim was to characterize the SMC phenotype in the intima and media of coronary arteries from young SCD victims. METHODS AND RESULTS: A total of 38 coronary artery segments were studied: (a) 18 APs from young (≤40 years old) SCD patients, (b) 9 APs from old (>40 years old) SCD patients, (c) 11 non-atherosclerotic coronary arteries from young patients (≤40 years old)...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29771429/the-relationship-between-number-and-function-of-epcs-and-concentration-of-vegf165-and-sdf-1-in-coronary-artery-spasm
#2
Z-Q Sheng, Y-F Li, K-L Zheng, H-H Lu, J Xie, H Wu, B Xu
OBJECTIVE: We aimed at investigating the functions of endothelial progenitor cells (EPCs) in the pathophysiology of coronary artery spasm (CAS) and coronary artery disease (CAD), as well as to evaluate the correlation of these diseases with the number and function of EPCs, the plasma concentration of vascular endothelial growth factor 165 (VEGF165) and stromal cell-derived factor 1 (SDF-1). PATIENTS AND METHODS: Participants were recruited into three groups, CAS, CAD and the control...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29767330/comparison-of-procedural-success-between-two-radial-sheaths-comparison-of-the-6-fr-glidesheath-slender-to-6-fr-standard-sheath
#3
B Gul, M Stolar, B Stair, P Hermany, S Willis, C Mena-Hurtado, R Attaran
BACKGROUND: The most common cause of procedural failure in cardiac catheterization using the transradial approach is radial artery spasm. The aim of this study was to compare the procedural success rate of the 6‑Fr Glidesheath Slender with the 6‑Fr standard sheath in transradial coronary angiography and intervention. METHODS: Patients who underwent percutaneous coronary angiography via the transradial approach through placement of a 6-Fr Glidesheath Slender or a 6-Fr standard sheath for primary radial access were prospectively enrolled in the study...
May 16, 2018: Herz
https://www.readbyqxmd.com/read/29736108/acute-coronary-syndrome-with-normal-coronary-arteries-a-case-of-spontaneous-spasm-lysis
#4
Vogiatzis Ioannis, Koutsambasopoulos Konstantinos, Samaras Antonios, Bostanitis Ioannis
Introduction: Patients suffering from Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) are found with no obstructive coronary artery disease on coronary arteriography. The Aim of this interesting case report is to present a patient with acute chest pain, temporal ST-segment elevation and MINOCA. Case report: A case of a young woman who presented with acute chest pain suggestive of angina, with temporal ST-segment elevation, accidentally recorded and not rising of myocardial necrosis biomarkers in blood tests is described...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29735411/vasospastic-myocardial-infarction-complicated-with-bilateral-femoral-arteries-vasospasm
#5
Chengzhi Gao, Huapeng Yu, Daixu Li, Qiang Liu
Coronary vasospasm is an infrequent cause of acute coronary syndrome. Additionally, femoral artery spasm is not frequently encountered clinically. Here we present a case of a patient with an acute ST segment elevation myocardial infarction, secondary to a documented right coronary artery vasospasm, complicated with left coronary artery and femoral artery vasospasm. Intravenous ultrasound showed calcification at the sites of spasm. This case report indicates that coronary vasospasm should be regularly considered as part of the work up of myocardial infarction...
April 17, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29731349/coronary-artery-ectasia-an-independent-predictor-of-no-reflow-after-primary-pci-for-st-elevation-myocardial-infarction
#6
H C F Schram, V V Hemradj, R S Hermanides, E Kedhi, J P Ottervanger
BACKGROUND: The no-reflow phenomenon is a serious complication after primary percutaneous coronary intervention (PCI) for ST-elevation Myocardial Infarction (STEMI). Coronary artery ectasia (CAE) may increase the risk of no-reflow, however, only limited data is available on the potential impact of CAE. The aim of this study was to determine the potential association between CAE and no-reflow after primary PCI. METHODS: A case control study was performed based on a prospective cohort of STEMI patients from January 2000 to December 2011...
April 25, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29667218/early-repolarization-is-involved-in-ventricular-fibrillation-in-patients-with-variant-angina
#7
Tetsuji Shinohara, Hidekazu Kondo, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
BACKGROUND: Variant angina (VA) is caused by reversible coronary artery spasm, which is characterized by chest pain with ST segment elevations on a standard 12-lead electrocardiogram (ECG) at rest. VA attack often causes lethal ventricular arrhythmia. The early repolarization (ER) pattern is associated with ventricular fibrillation (VF). However, whether the ER pattern is involved in VF in patients with VA is not known. We investigated the association between the ER pattern and VF in patients with VA...
April 17, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29666683/effects-of-peer-facilitated-video-based-and-combined-peer-and-video-education-on-anxiety-among-patients-undergoing-coronary-angiography-randomised-controlled-trial
#8
Hosein Habibzadeh, Zahra D Milan, Moloud Radfar, Leyla Alilu, Audrey Cund
Objectives: Coronary angiography can be stressful for patients and anxiety-caused physiological responses during the procedure increase the risk of dysrhythmia, coronary artery spasms and rupture. This study therefore aimed to investigate the effects of peer, video and combined peer-and-video training on anxiety among patients undergoing coronary angiography. Methods: This single-blinded randomised controlled clinical trial was conducted at two large educational hospitals in Iran between April and July 2016...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29609021/activation-of-the-monocytic-%C3%AE-7-nicotinic-acetylcholine-receptor-modulates-oxidative-stress-and-inflammation-associated-development-of-coronary-artery-spasm-via-a-p38-map-kinase-signaling-dependent-pathway
#9
Ming-Yow Hung, Yi-Hong Wu, Oluwaseun Adebayo Bamodu, Xi Chen, Yen-Kuang Lin, Patrick Hu, Nen-Chung Chang, Jong-Hwei Su Pang, Chi-Tai Yeh
OBJECTIVE: Smoking and high-sensitivity C-reactive protein (hs-CRP) are risk factors for coronary artery spasm (CAS), which is characterized by the increased interleukin-6 (IL-6) level and monocyte counts; however, limited data are available regarding the role of cigarette-embedded nicotine in the modulation of monocytic inflammatory activity in CAS. APPROACH: We investigated and elucidated the putative roles and associations of nicotine, monocytic IL-6, α7 nicotinic acetylcholine receptor (α7-nAChR), and CRP in CAS development...
March 31, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29578203/coronary-angiography-using-the-left-distal-radial-approach-an-alternative-site-to-conventional-radial-coronary-angiography
#10
Elton Soydan, Mustafa Akın
OBJECTIVE: To share our experience with the left distal radial approach for transradial coronary angiography and interventions. By performing the radial puncture in the fossa radialis or the so called anatomical "Snuffbox" we aimed to present the feasibility and complications of this new technique. METHODS: Left distal radial artery was used as an access site in 54 patients admitted to our clinic for coronary angiography and intervention between May 25th and October 20th 2017...
March 21, 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29577707/-research-progress-and-forensic-application-on-the-pathogenesis-of-coronary-artery-spasm
#11
REVIEW
C X Que, Y J Yu, H Chen, C Shi, A M Xue
Coronary artery spasm (CAS) is a hyper-contraction of segmental coronary artery in response to multiple stimuli. At present, it's still in lack of specific diagnostic indicators of sudden cardiac death caused by CAS. This review summarizes current researches on the mechanisms of CAS and describes the roles of vascular endothelial dysfunction and vascular smooth muscle hypersensitivity in the course of CAS. Furthermore, the molecular mechanisms of the endogenous NO and endothelin-1 cause vascular endothelial dysfunction, and the phosphorylation of MLC2, Rho kinase and endoplasmic reticulum stress related to vascular smooth muscle hypersensitivity are discussed...
February 2018: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29552237/coronary-arterial-spasm-detected-by-coronary-computed-tomography-angiography-and-confirmed-by-intravascular-ultrasound
#12
Masafumi Nakayama, Masaharu Hirano, Sonoka Goto, Akifumi Watanabe, Takashi Uchiyama
A 40-year-old man was admitted to our hospital for chest pain after smoking. Coronary computed tomography angiography showed severe stenosis in the left anterior descending artery. The stenosis site had no plaque on stretched curved multiplanar reconstruction and short-axis images. Coronary angiography revealed improvement of the severe stenosis after the intracoronary administration of isosorbide dinitrate in the left anterior descending artery. Intravascular ultrasound demonstrated negative remodeling without a plaque and diffuse intima with media thickening at the stenosis site...
February 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29526680/endothelial-dysfunction-of-coronary-arteries-in-subjects-without-diabetes-an-association-with-both-insulin-resistance-and-impaired-insulin-secretion-response
#13
Katarina Lalić, Milan Nedeljković, Alekasandra Jotić, Rade Babić, Nataša Rajković, Ljiljana Popović, Ljiljana Lukić, Tanja Miličić, Sandra Singh Lukač, Ljubica Stošić, Marija Maćešić, Iva Rasulić, Jelena Stanarčić Gajović, Nebojša M Lalić
AIMS: This study was aimed to compare insulin sensitivity and secretion response, lipoprotein and plasminogen activator inhibitor 1 (PAI-1) levels between the subjects with and without coronary artery endothelial dysfunction (ED). METHODS: ED was detected by intracoronary injection of acetylcholine (ACh) in 47 nondiabetes subjects without stenotic coronary arteries, selected from 316 consecutive patients with coronary angiography performed for suspected coronary artery disease...
May 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29521870/the-effect-of-topical-medications-on-radial-artery-spasm-in-patients-undergoing-transradial-coronary-procedures-a-systematic-review
#14
Elizabeth Curtis, Ritin Fernandez, Astin Lee
OBJECTIVE: The objective of this review was to identify the effectiveness of topical medications on radial artery spasm (RAS) in patients undergoing transradial percutaneous coronary procedures. INTRODUCTION: Percutaneous coronary procedures were traditionally carried out via the femoral artery; however, over the last 20 years there has been a global increase in the number of proceduralists carrying out percutaneous coronary procedures via the transradial approach...
March 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29520510/variant-angina-and-aborted-sudden-cardiac-death
#15
REVIEW
Amartya Kundu, Aditya Vaze, Partha Sardar, Ahmed Nagy, Wilbert S Aronow, Naomi F Botkin
PURPOSE OF REVIEW: Variant angina, which is characterized by recurrent chest pain and transient ECG changes along with angiographic evidence of coronary artery spasm, generally has a favorable prognosis. However, episodes of ischemia caused by vasospasm may lead to potentially life-threatening ventricular arrhythmias and cardiac arrest, even in patients with no history of prior cardiac disease. This review describes the epidemiology, pathogenesis, clinical spectrum, and management of variant angina, as well as outcomes in patients who present with aborted sudden cardiac death (ASCD)...
March 8, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29509526/recurrent-coronary-artery-spasm-induced-by-vasopressors-during-two-operations-in-the-same-patient-under-general-anesthesia
#16
Naotaka Kishimoto, Munenori Kato, Yasunori Nakanishi, Akari Hasegawa, Yoshihiro Momota
Variant angina is caused by coronary artery spasm (CAS) with ST-segment elevation. We herein report a case of recurrent CAS during 2 operations in the same patient. An 80-year-old woman was scheduled to undergo tracheostomy, submandibular dissection, left partial maxillectomy, and coronoidectomy. We administered ephedrine and phenylephrine to manage hypotension during general anesthesia. Immediately after the administration of these drugs, the ST segment elevated. We decided to cease the operation and transport the patient to the department of cardiology...
2018: Anesthesia Progress
https://www.readbyqxmd.com/read/29506741/effect-of-coronary-artery-spasm-on-long-term-outcomes-in-survivors-of-acute-myocardial-infarction
#17
Juntaro Deyama, Takamitsu Nakamura, Yukio Saito, Jun-Ei Obata, Daisuke Fujioka, Kazuto Nakamura, Kazuhiro Watanabe, Kiyotaka Kugiyama
BACKGROUND: The prevalence of coronary artery spasm (CAS) inducible by intracoronary injection of acetylcholine (ACh) is high in survivors of acute myocardial infarction (AMI). Although there is a potential risk of sudden cardiac death in patients with CAS, the prognostic value of CAS was not clear. Thus, this study examined the effect of CAS on long-term prognosis in survivors of AMI in a prospective manner. METHODS: The study included a total of 437 patients with AMI who underwent a CAS provocation test using ACh...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29473355/-clinical-research-of-vasospasm-and-vagus-reflex-during-radial-artery-puncture-treated-with-auricular-point-sticking
#18
Xiaoyan Fan, Yanping Liu, Jinhong Xie, Yushan Chen, Yanyan Cao
OBJECTIVE: To evaluate the effect and clinical value of auricular point sticking for the diagnosis and treatment of vasospasm and vagus reflex during radial artery puncture, including radial artery spasm (RAS) and coronary artery spasm (CAS). METHODS: A total of 480 patients were randomized into an observation group (224 cases) and a control group (256 cases). Percutaneous coronary intervention and usual care in perioperative period were used in the control group...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29455773/takotsubo-syndrome
#19
REVIEW
Sanjiv Gupta, Madan Mohan Gupta
Takotsubo syndrome is a reversible acute heart failure frequently precipitated by an emotional or physical stress. The clinical presentation resembles acute coronary syndrome. Pathogenesis is complex and may involve brain-heart axis and neuro-hormonal stunning of the myocardium. Coronary angiography reveals normal epicardial arteries with no obstruction or spasm. NT-ProBNP maybe remarkably elevated. Regional wall motion akinesia (RWMA) of left ventricle extends beyond the territory of one coronary artery. Reduced left ventricle ejection fraction (LVEF) and RWMA recover in 6-12 weeks...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29437817/atherothrombotic-out-of-hospital-cardiac-arrest-watch-out-for-a-second-train
#20
Laura Petruescu, Fabien Picard, Alain Cariou, Olivier Varenne
A 63-year-old man presented with an out-of-hospital cardiac arrest. The coronary angiogram with intravascular imaging was performed and showed a mid-left anterior descending artery atherosclerotic cap rupture with thrombus burden treated with drug-eluting stent (DES) implantation. During the hospitalisation in the intensive care unit, the patient experienced recurrent ventricular fibrillations and asystole with transient ST-segment elevation in the inferior leads with normal coronary angiography. A methylergonovine provocative test was therefore performed and showed an occlusive right coronary artery (RCA) spasm...
February 8, 2018: BMJ Case Reports
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