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J Fenn, E Laber, K Williams, C A Rousse, P J Early, C L Mariani, K R Muñana, S De Decker, H A Volk, N J Olby
BACKGROUND: Outcome of acute experimental spinal cord injury is strongly associated with tissue perfusion and oxygenation. Cardiopulmonary depression could affect outcome in dogs undergoing general anesthesia for surgical treatment of thoracolumbar intervertebral disk extrusion (IVDE). HYPOTHESIS/OBJECTIVES: To evaluate the effects of general anesthesia on functional outcome in dogs undergoing surgery to treat thoracolumbar IVDE. ANIMALS: Eighty-four client-owned dogs with acute thoracolumbar IVDE treated by decompressive hemilaminectomy...
March 13, 2017: Journal of Veterinary Internal Medicine
Ji-Hey Lim, Sehwon Koh, Rachael Thomas, Matthew Breen, Natasha J Olby
OBJECTIVE To evaluate gene expression and DNA copy number in adipose tissue-derived stromal cells (ADSCs) and in ADSC-derived neurosphere-like cell clusters (ADSC-NSCs) generated from tissues of chronically paraplegic dogs. ANIMALS 14 client-owned paraplegic dogs. PROCEDURES Dorsal subcutaneous adipose tissue (< 1 cm(3)) was collected under general anesthesia; ADSCs were isolated and cultured. Third-passage ADSCs were cultured in neural cell induction medium to generate ADSC-NSCs. Relative gene expression of mesenchymal cell surface marker CD90 and neural progenitor marker nestin was assessed in ADSCs and ADSC-NSCs from 3 dogs by quantitative real-time PCR assay; expression of these and various neural lineage genes was evaluated for the same dogs by reverse transcription PCR assay...
March 2017: American Journal of Veterinary Research
Sarah A Moore, Nicolas Granger, Natasha J Olby, Ingo Spitzbarth, Nick D Jeffery, Andrea Tipold, Yvette S Nout-Lomas, Ronaldo C da Costa, Veronika M Stein, Linda J Noble-Haeusslein, Andrew R Blight, Robert G Grossman, D Michele Basso, Jonathan M Levine
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic has been historically challenging, highlighting the need for robust models of injury that more closely mirror the human condition. The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to evaluate expeditiously promising interventions in a population of animals that receive diagnoses and treatment clinically in a manner similar to persons with SCI, while adhering to National Institutes of Health guidelines for scientific rigor and transparent reporting...
March 22, 2017: Journal of Neurotrauma
N J Olby, S L Vaden, K Williams, E H Griffith, T Harris, C L Mariani, K R Muñana, P J Early, S R Platt, L Boozer, C Giovanella, R Longshore
BACKGROUND: Dogs with spinal cord injury are at increased risk of developing bacteriuria due to increased residual urine volume. Cranberry extract inhibits binding of E. coli to uroepithelial cells, potentially reducing risk of bacteriuria. HYPOTHESIS: Cranberry extract reduces risk of bacteriuria in dogs after acute TL-IVDH. ANIMALS: Client-owned dogs with acute onset TL-IVDH causing nonambulatory status. METHODS: Randomized, placebo-controlled, blinded, prospective clinical trial...
January 2017: Journal of Veterinary Internal Medicine
Bryony Sales, Alexandra Macdonald, Samantha Scallan, Sue Crane
CONTEXT: Burnout impacts adversely on professional and personal life, and holds implications for patient care. Current research on burnout mainly focuses on established general practitioners but it is unclear how early the signs of burnout really start. This work seeks to identify whether specific GP trainee groups are particularly at risk of burnout and the aspects of training they find stressful. METHODS: A longitudinal cohort study, collecting qualitative and quantitative data through a single mode of data collection (questionnaire) took place with trainees from all GP training years (ST1-3), across a vocational training scheme (n = 48)...
November 2016: Education for Primary Care
K A Bartholomew, K E Stover, N J Olby, S A Moore
Fibrocartilaginous embolic myelopathy (FCE) is common in dogs; however, there is conflicting information in the veterinary literature regarding clinical characteristics and data on recovery in severe cases is sparse. A systematic review of canine FCE was performed to delineate the natural history of this disease. 322 previously reported cases and 71 previously unreported cases were identified for inclusion. Source publications were identified via PubMed central search and by references from review articles...
December 24, 2016: Veterinary Record
Ji-Hey Lim, Natasha J Olby
OBJECTIVE To identify an optimal technique for isolation, purification, and amplification of Schwann cells (SCs) from biopsy specimens of the dorsal cutaneous branches of the cervical nerves of dogs. SAMPLE Biopsy specimens of dorsal cervical cutaneous nerves from the cadavers of three 1- to 2-year-old dogs. PROCEDURES Nerve specimens were dissected, predegenerated, and dissociated to isolate single cells. After culture to enhance SC growth, cells were immunopurified by use of magnetic beads. Cell purity was evaluated by assessing expression of cell surface antigens p75 (to detect SCs) and CD90 (to detect fibroblasts)...
October 2016: American Journal of Veterinary Research
M J Lewis, N J Olby, P J Early, C L Mariani, K R Muñana, G S Seiler, E H Griffith
BACKGROUND: Quantification of brain herniation on MRI and its immediate clinical implications are poorly described. OBJECTIVES: Define the normal position of caudal fossa structures on brain MRIs in dogs and cats utilizing morphometry, compare this to dogs and cats with caudal transtentorial herniation (CTH), foramen magnum herniation (FMH) or both identified on MRI, and investigate associations between herniation severity, clinical signs, and 24-hour outcome. ANIMALS: Ninety-two controls (66 dogs, 26 cats), 119 cases with herniation (88 dogs, 31 cats)...
September 2016: Journal of Veterinary Internal Medicine
S Cerda-Gonzalez, N J Olby, E H Griffith
BACKGROUND: Craniocervical junction (CCJ) anomalies and secondary syringomyelia are commonly diagnosed in Cavalier King Charles spaniel (CKCS). Familiarity with the natural history of these abnormalities is vital to understanding the disease syndrome. OBJECTIVE: To evaluate magnetic resonance imaging (MRI) predictors of worsening clinical signs, syringomyelia, and morphology in CKCS longitudinally. ANIMALS: Fifty-four client-owned CKCS, 5-13 years old; 50% currently symptomatic...
July 2016: Journal of Veterinary Internal Medicine
C A Rousse, N J Olby, K Williams, T L Harris, E H Griffith, C L Mariani, K R Muñana, P J Early
Prospective data on the recovery of coordination in dogs suffering acute thoracolumbar intervertebral disc herniations (TL-IVDH) are limited. The purpose of this study was to use treadmill based and open field scores (OFS) to quantify recovery of stepping ability and forelimb, hindlimb coordination in the 6 weeks following surgical decompression of dogs with TL-IVDH. Sixty-three dogs were grouped at presentation as grades 3 (non-ambulatory paraparetic), 4 (paraplegic) or 5 (paraplegic without pain sensation) and were evaluated 2, 4, and 6 weeks post-operatively...
July 2016: Veterinary Journal
Łukasz Baka, Beata A Basińska
BACKGROUND: The objective of this study was to test the psychometric properties of the Polish version of the Oldenburg Burnout Inventory (OLBI) - its factor structure, reliability, validity and standard norms. MATERIAL AND METHODS: The study was conducted on 3 independent samples of 1804, 366 and 48 workers employed in social service and general service professions. To test the OLBI structure the exploratory factor analysis was conducted. The reliability was assessed by means of Cronbach's α coefficient (the internal consistent) and test-retest (the stability over time) method, with a 6-week follow-up...
2016: Medycyna Pracy
A Castel, N J Olby
No abstract text is available yet for this article.
April 2016: Journal of Small Animal Practice
A M Gorney, S R Blau, C S Dohse, E H Griffith, K D Williams, J-H Lim, D Knazovicky, B D X Lascelles, N J Olby
BACKGROUND: Intervertebral disc herniation is a common cause of spinal cord injury (SCI) causing paralysis and sensory loss. Little quantitative information is available on the loss and recovery of sensation in dogs with SCI. OBJECTIVES: To determine whether quantitative sensory testing (QST) can be used to establish thermal and mechanical sensory thresholds in chrondrodystrophoid dogs and compare thresholds among normal dogs and dogs with different grades of SCI...
March 2016: Journal of Veterinary Internal Medicine
Steven G Friedenberg, Greg Buhrman, Lhoucine Chdid, Natasha J Olby, Thierry Olivry, Julien Guillaumin, Theresa O'Toole, Robert Goggs, Lorna J Kennedy, Robert B Rose, Kathryn M Meurs
Immune-mediated diseases are common and life-threatening disorders in dogs. Many canine immune-mediated diseases have strong breed predispositions and are believed to be inherited. However, the genetic mutations that cause these diseases are mostly unknown. As many immune-mediated diseases in humans share polymorphisms among a common set of genes, we conducted a candidate gene study of 15 of these genes across four immune-mediated diseases (immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, immune-mediated polyarthritis (IMPA), and atopic dermatitis) in 195 affected and 206 unaffected dogs to assess whether causative or predictive polymorphisms might exist in similar genes in dogs...
March 2016: Immunogenetics
Rohan Shad, Rajat Thawani, Ashish Goel
Introduction It is well documented that on entering college, students experience a multitude of changes in sleep habits. Very few studies have been conducted that explore sleep quality in Indian undergraduate students; fewer still study the effects of burnout in the same population. Medical students, in particular, are believed to be more stressed, sleep deprived, and burnt out than their non-medical peers. Methods A cross-sectional study was conducted to study sleep disturbances and burnout in a sample of 214 Indian undergraduate students (112 medical, 102 non-medical)...
2015: Curēus
N J Olby, A C Muguet-Chanoit, J-H Lim, M Davidian, C L Mariani, A C Freeman, S R Platt, J Humphrey, M Kent, C Giovanella, R Longshore, P J Early, K R Muñana
BACKGROUND: Acute intervertebral disk herniation (IVDH) is a common cause of spinal cord injury in dogs and currently there is no proven medical treatment to counter secondary injury effects. Use of methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants is advocated but controversial because neither treatment has been tested in placebo-controlled, randomized, blinded trials in dogs. HYPOTHESIS: Polyethylene glycol will improve the outcome of severe spinal cord injury caused by IVDH compared to MPSS or placebo...
January 2016: Journal of Veterinary Internal Medicine
Dorota Włodarczyk, Anna Pawliszewska
BACKGROUND: Working at intensive care unit (ICU) is one ot the most difticult and taxing nursing speciaites. It demans not only extensive knowledge and professional skills but also specific personality temperamental dispositions. The aim of the study was to verify if typeA behavior (TAB) is a predictor ofburnout and job satisfaction in ICU nurses and if this effect still exists after controlling for selected demographic and job characteristics. MATERIAL AND METHODS: The study group consisted of 99 nurses (77 women), aged 24-58 (mean (M) = 32...
2015: Medycyna Pracy
S Cerda-Gonzalez, N J Olby, E H Griffith
BACKGROUND: Dorsal compressive lesions at the atlantoaxial junction (ie, AA bands) occur in dogs with Chiari-like malformations (CMs), but their clinical relevance is unclear. OBJECTIVE: Investigate the influence of AA bands on clinical status and syringomyelia (SM) in mature cavalier King Charles spaniels (CKCS). ANIMALS: Thirty-six CKCS, 5-12 years of age, including 20 dogs with neuropathic pain. METHODS: Dogs were examined and assigned a neurologic grade...
May 2015: Journal of Veterinary Internal Medicine
Carlos Alberto Palmeira Sarmento, Marcio Nogueira Rodrigues, Renato Zonzini Bocabello, Andrea Maria Mess, Maria Angelica Miglino
BACKGROUND: Chronic Spinal Cord injury is a common, severe, and medically untreatable disease. Since the functional outcomes of acute and experimental chronic spinal cord injury have been shown to improve with stem cell therapy, a case study was conducted to test if the application of stem cell also regenerates chronic SCI dysfunction. Transplantation of foetal bone marrow stem cells was applied in seven dogs with chronic spinal cord injury. Magnetic resonance images and assessments of symptoms according to the Olby scale were used to diagnose the severity of injury...
December 2014: Regenerative Medicine Research
S Cerda-Gonzalez, N J Olby, E H Griffith
BACKGROUND: Medullary elevation (ie, medullary kinking) at the craniocervical junction (CCJ) is reported in dogs with Chiari-like malformations (CM), but its diagnostic criteria and clinical relevance are unclear. OBJECTIVE: To describe the position of the medulla at the CCJ in mature cavalier King Charles spaniels (CKCS), and evaluate its relationship with clinical status and the presence of syringomyelia. ANIMALS: Thirty-six CKCS, 5-12 years of age, including 16 asymptomatic dogs...
May 2015: Journal of Veterinary Internal Medicine
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