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Claudia P Estévez-Mujica, Eric Quintane
A considerable body of research has documented the negative effects of job burnout on employees and their organizations, emphasizing the importance of the identification of early signs of the phenomenon for the purposes of prevention and intervention. However, such timely identification is difficult due to the time and cost of assessing the burnout levels of all employees in an organization using established scales. In this paper, we propose an innovative way to identify employees at risk of job burnout by analyzing their e-mail communication patterns...
2018: PloS One
Steven G Friedenberg, Daniella Vansteenkiste, Oriana Yost, Amy E Treeful, Kathryn M Meurs, Debra A Tokarz, Natasha J Olby
BACKGROUND: We aimed to identify mutations associated with osteochondromatosis in a litter of American Staffordshire Terrier puppies. HYPOTHESIS: We hypothesized that the associated mutation would be located in a gene that causes osteochondromatosis in humans. ANIMALS: A litter of 9 American Staffordshire puppies, their sire and dam, 3 of 4 grandparents, 26 healthy unrelated American Staffordshire Terriers, and 154 dogs of 27 different breeds...
February 27, 2018: Journal of Veterinary Internal Medicine
Julien Guevar, Natasha J Olby, Kathryn M Meurs, Oriana Yost, Steven G Friedenberg
BACKGROUND: A congenital syndrome of hearing loss and vestibular dysfunction affects Doberman Pinschers. Its inheritance pattern is suspected to be autosomal recessive and it potentially represents a spontaneous animal model of an autosomal recessive syndromic hearing loss. HYPOTHESIS/OBJECTIVES: The objectives of this study were to use whole genome sequencing (WGS) to identify deleterious genetic variants in candidate genes associated with the syndrome and to study the prevalence of candidate variants among a population of unaffected Doberman Pinschers...
February 20, 2018: Journal of Veterinary Internal Medicine
Marcelo da Silva Schuster, Valéria da Veiga Dias
This study sought to validate the Oldenburg Burnout Inventory (OLBI) measurement scale in Brazil. The methodology included data collection through a quantitative survey with 273 people. Structural equation modeling was used for data analysis. The scale was validated after being subjected to all statistical assumptions, reducing the original 16 to 13 variables resulting in an enhanced measurement capacity of the Burnout syndrome than the original scale. This study contributes a scale adapted to Brazil to study the health of the worker, since it provides a way to measure a syndrome responsible for problems of various types, with impacts both inside and outside organizations...
February 2018: Ciência & Saúde Coletiva
Artur Kamiński, Hanna Rozenek, Jolanta Banasiewicz, Stanisław Wójtowicz, Artur Błoński, Krzysztof Owczarek
Job Demands-Resources model proposes that the development of burnout follows excessive job demands and lack of job resources. Job demands are predictive of feeling of exhaustion, and lack of job resources-disengagement from work. This pilot study investigated professional burnout and its correlates in employees of Polish cell and tissue banks, many of whom were involved in procurement and processing of tissues from deceased donors, as it was hypothesized that job burnout in this population might influence the effectiveness of cell and tissue transplantation network in our country...
February 3, 2018: Cell and Tissue Banking
Natalia Zidan, Joe Fenn, Emily Griffith, Peter J Early, Chris L Mariani, Karen R Munana, Julien Guevar, Natasha Olby
Spinal cord injury (SCI) due to acute intervertebral disc extrusions (IVDE) is common in dogs and is treated by surgical decompression. Dogs with sensorimotor complete injuries have an incomplete recovery. Pulsed electromagnetic fields (PEMF) reduce postoperative pain through anti-inflammatory effects and there is growing evidence for neuroprotective effects. This randomized, controlled clinical trial evaluated the effect of PEMF on post-operative pain and neurologic recovery in dogs with surgically treated sensorimotor complete SCI due to acute IVDE...
January 8, 2018: Journal of Neurotrauma
C R Sparks, S Cerda-Gonzalez, E H Griffith, B D X Lascelles, N J Olby
BACKGROUND: Chiari-like malformation (CM) and syringomyelia (SM) cause a pain syndrome in Cavalier King Charles spaniels (CKCS). Clinical signs are not consistently apparent on neurologic examination, and owner reporting of signs provides vital clinical history. However, owner questionnaires for this disease are not well developed. OBJECTIVES: To develop a tool to capture owner-reported clinical signs for use in clinical trials and to compare owner-reported signs with the presence of pain on neurologic examination and SM on magnetic resonance imaging (MRI)...
November 4, 2017: Journal of Veterinary Internal Medicine
Melissa J Lewis, Eli B Cohen, Natasha J Olby
STUDY DESIGN: Retrospective case series. OBJECTIVES: Describe the magnetic resonance imaging (MRI) features of dogs chronically impaired after severe spinal cord injury (SCI) and investigate associations between imaging variables and residual motor function. SETTING: United States of America. METHODS: Thoracolumbar MRI from dogs with incomplete recovery months to years after clinically complete (paralysis with loss of pain perception) thoracolumbar SCI were reviewed...
October 23, 2017: Spinal Cord
S Rafatpanah Baigi, S Vaden, N J Olby
BACKGROUND: Paralysis is a known risk factor for urinary tract infections (UTI), sepsis, and death in paralyzed people, but there are no data available on diagnostic criteria for UTI versus bacteriuria, their frequency, or clinical implications in chronically paralyzed dogs. HYPOTHESIS/OBJECTIVES: That chronically paralyzed dogs suffer frequent bacteriuria causing reduced duration of survival. We documented the frequency of bacteriuria, associated clinical signs, and survival rate in chronically paralyzed dogs...
November 2017: Journal of Veterinary Internal Medicine
Melissa J Lewis, Pew-Thian Yap, Susan McCullough, Natasha J Olby
Lesion heterogeneity among chronically paralyzed dogs after acute, complete thoracolumbar spinal cord injury (TLSCI) is poorly described. We hypothesized that lesion severity quantified by diffusion tensor imaging (DTI) is associated with hindlimb motor function. Our objectives were to quantify lesion severity with fractional anisotropy (FA), mean diffusivity (MD), and tractography and investigate associations with motor function. Twenty-two dogs with complete TLSCI in the chronic stage were enrolled and compared with six control dogs...
November 17, 2017: Journal of Neurotrauma
A Castel, N J Olby, C L Mariani, K R Muñana, P J Early
BACKGROUND: Progressive myelomalacia (PMM) is a catastrophic disease associated with acute intervertebral disc extrusion (IVDE). Published data on the clinical characteristics of this disease are limited. OBJECTIVE: To describe the onset and progression of clinical signs of PMM in a large case cohort. ANIMALS: Fifty-one dogs, 18 with histopathologically confirmed PMM, 33 presumptively diagnosed based on clinical signs and diagnostic imaging...
November 2017: Journal of Veterinary Internal Medicine
S R Blau, L M Davis, A M Gorney, C S Dohse, K D Williams, J-H Lim, W G Pfitzner, E Laber, G S Sawicki, N J Olby
The center of pressure (COP) position reflects a combination of proprioceptive, motor and mechanical function. As such, it can be used to quantify and characterize neurologic dysfunction. The aim of this study was to describe and quantify the movement of COP and its variability in healthy chondrodystrophoid dogs while walking to provide a baseline for comparison to dogs with spinal cord injury due to acute intervertebral disc herniations. Fifteen healthy adult chondrodystrophoid dogs were walked on an instrumented treadmill that recorded the location of each dog's COP as it walked...
August 2017: Veterinary Journal
Matheus Levi Tajra Feitosa, Carlos Alberto Palmeira Sarmento, Renato Zonzini Bocabello, Patrícia Cristina Baleeiro Beltrão-Braga, Graciela Conceição Pignatari, Robson Fortes Giglio, Maria Angelica Miglino, Jéssica Rodrigues Orlandin, Carlos Eduardo Ambrósio
Purpose: To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs. Methods: Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative. Results: There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation...
July 2017: Acta Cirúrgica Brasileira
Melissa J Lewis, Natasha J Olby
OBJECTIVE To develop a spasticity scale for dogs with chronic deficits following severe spinal cord injury (SCI) for use in clinical assessment and outcome measurement in clinical trials. ANIMALS 20 chronically paralyzed dogs with a persistent lack of hind limb pain perception caused by an acute SCI at least 3 months previously. PROCEDURES Spasticity was assessed in both hind limbs via tests of muscle tone, clonus, and flexor and extensor spasms adapted from human scales. Measurement of patellar clonus duration and flexor spasm duration and degree was feasible...
July 2017: American Journal of Veterinary Research
Agnieszka Springer, Karolina Oleksa
BACKGROUND: Nowadays more and more employees are required to perform emotional labor (EL) which means that they need to express emotions set by the organizational procedures, simultaneously masking the true feelings. Employees, while performing emotional labor, choose between one of the two strategies (surface acting or deep acting) and this leads to e.g., burnout. As the performance of emotional labor and its consequences depend on the specification of work and chosen strategy, it was assumed that the consequences of EL may be different for workers in various occupations...
July 26, 2017: Medycyna Pracy
Cláudia Cardoso Maciel Escalhão, Isalira Peroba Ramos, Camila Hochman-Mendez, Tais Hanae Kasai Brunswick, Sergio Augusto Lopes Souza, Bianca Gutfilen, Regina Coeli Dos Santos Goldenberg, Tatiana Coelho-Sampaio
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with (99m)Technetium, and transplanted into the lesion by percutaneous X-ray-guided injection...
2017: Stem Cells International
G Urkasemsin, D M Nielsen, A Singleton, S Arepalli, D Hernandez, C Agler, N J Olby
BACKGROUND: Scottish Terriers have a high incidence of juvenile onset hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex and causing slowly progressive cerebellar dysfunction. OBJECTIVE: To identify chromosomal regions associated with hereditary ataxia in Scottish Terriers. ANIMALS: One hundred and fifty-three Scottish Terriers were recruited through the Scottish Terrier Club of America. MATERIALS AND METHODS: Prospective study...
July 2017: Journal of Veterinary Internal Medicine
Melissa J Lewis, James F Howard, Natasha J Olby
Spontaneous, acute, complete thoracolumbar spinal cord injury (TL-SCI) in dogs frequently results in permanent deficits modeling chronic paralysis in people. Recovery of walking without recovery of sensation has been interpreted in dogs as reflexive spinal walking. To evaluate this assumption, this study characterized the electrophysiological status of motor and sensory long tracts and local reflex circuitry in dogs with absent recovery of sensation after acute TL-SCI and correlated findings to gait scores...
November 1, 2017: Journal of Neurotrauma
J Fenn, E Laber, K Williams, C A Rousse, P J Early, C L Mariani, K R Muñana, S De Decker, H A Volk, N J Olby
BACKGROUND: Outcome of acute experimental spinal cord injury is strongly associated with tissue perfusion and oxygenation. Cardiopulmonary depression could affect outcome in dogs undergoing general anesthesia for surgical treatment of thoracolumbar intervertebral disk extrusion (IVDE). HYPOTHESIS/OBJECTIVES: To evaluate the effects of general anesthesia on functional outcome in dogs undergoing surgery to treat thoracolumbar IVDE. ANIMALS: Eighty-four client-owned dogs with acute thoracolumbar IVDE treated by decompressive hemilaminectomy...
May 2017: Journal of Veterinary Internal Medicine
Ji-Hey Lim, Sehwon Koh, Rachael Thomas, Matthew Breen, Natasha J Olby
OBJECTIVE To evaluate gene expression and DNA copy number in adipose tissue-derived stromal cells (ADSCs) and in ADSC-derived neurosphere-like cell clusters (ADSC-NSCs) generated from tissues of chronically paraplegic dogs. ANIMALS 14 client-owned paraplegic dogs. PROCEDURES Dorsal subcutaneous adipose tissue (< 1 cm(3)) was collected under general anesthesia; ADSCs were isolated and cultured. Third-passage ADSCs were cultured in neural cell induction medium to generate ADSC-NSCs. Relative gene expression of mesenchymal cell surface marker CD90 and neural progenitor marker nestin was assessed in ADSCs and ADSC-NSCs from 3 dogs by quantitative real-time PCR assay; expression of these and various neural lineage genes was evaluated for the same dogs by reverse transcription PCR assay...
March 2017: American Journal of Veterinary Research
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