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https://www.readbyqxmd.com/read/28650240/development-of-a-clinical-spasticity-scale-for-evaluation-of-dogs-with-chronic-thoracolumbar-spinal-cord-injury
#1
Melissa J Lewis, Natasha J Olby
OBJECTIVE To develop a spasticity scale for dogs with chronic deficits following severe spinal cord injury (SCI) for use in clinical assessment and outcome measurement in clinical trials. ANIMALS 20 chronically paralyzed dogs with a persistent lack of hind limb pain perception caused by an acute SCI at least 3 months previously. PROCEDURES Spasticity was assessed in both hind limbs via tests of muscle tone, clonus, and flexor and extensor spasms adapted from human scales. Measurement of patellar clonus duration and flexor spasm duration and degree was feasible...
July 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28649999/-the-relationship-between-emotional-labor-and-professional-burnout-a-comparative-analysis-between-work-of-teachers-and-employees-of-commercial-service-sector
#2
Agnieszka Springer, Karolina Oleksa
BACKGROUND: Nowadays more and more employees are required to perform emotional labor (EL) which means that they need to express emotions set by the organizational procedures, simultaneously masking the true feelings. Employees, while performing emotional labor, choose between one of the two strategies (surface acting or deep acting) and this leads to e.g., burnout. As the performance of emotional labor and its consequences depend on the specification of work and chosen strategy, it was assumed that the consequences of EL may be different for workers in various occupations...
June 26, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28611846/safety-of-allogeneic-canine-adipose-tissue-derived-mesenchymal-stem-cell-intraspinal-transplantation-in-dogs-with-chronic-spinal-cord-injury
#3
Cláudia Cardoso Maciel Escalhão, Isalira Peroba Ramos, Camila Hochman-Mendez, Tais Hanae Kasai Brunswick, Sergio Augusto Lopes Souza, Bianca Gutfilen, Regina Coeli Dos Santos Goldenberg, Tatiana Coelho-Sampaio
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with (99m)Technetium, and transplanted into the lesion by percutaneous X-ray-guided injection...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28556454/genetics-of-hereditary-ataxia-in-scottish-terriers
#4
G Urkasemsin, D M Nielsen, A Singleton, S Arepalli, D Hernandez, C Agler, N J Olby
BACKGROUND: Scottish Terriers have a high incidence of juvenile onset hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex and causing slowly progressive cerebellar dysfunction. OBJECTIVE: To identify chromosomal regions associated with hereditary ataxia in Scottish Terriers. ANIMALS: One hundred and fifty-three Scottish Terriers were recruited through the Scottish Terrier Club of America. MATERIALS AND METHODS: Prospective study...
July 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28462632/the-relationship-between-trans-lesional-conduction-motor-neuron-pool-excitability-and-motor-function-in-dogs-with-incomplete-recovery-from-severe-spinal-cord-injury
#5
Melissa J Lewis, James F Howard, Natasha J Olby
Spontaneous, acute, complete thoracolumbar spinal cord injury (TL-SCI) in dogs frequently results in permanent deficits modeling chronic paralysis in people. Recovery of walking without recovery of sensation has been interpreted in dogs as reflexive spinal walking. To evaluate this assumption, this study characterized the electrophysiological status of motor and sensory long tracts and local reflex circuitry in dogs with absent recovery of sensation after acute TL-SCI and correlated findings to gait scores...
June 16, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28295616/associations-between-anesthetic-variables-and-functional-outcome-in-dogs-with-thoracolumbar-intervertebral-disk-extrusion-undergoing-decompressive-hemilaminectomy
#6
J Fenn, E Laber, K Williams, C A Rousse, P J Early, C L Mariani, K R Muñana, S De Decker, H A Volk, N J Olby
BACKGROUND: Outcome of acute experimental spinal cord injury is strongly associated with tissue perfusion and oxygenation. Cardiopulmonary depression could affect outcome in dogs undergoing general anesthesia for surgical treatment of thoracolumbar intervertebral disk extrusion (IVDE). HYPOTHESIS/OBJECTIVES: To evaluate the effects of general anesthesia on functional outcome in dogs undergoing surgery to treat thoracolumbar IVDE. ANIMALS: Eighty-four client-owned dogs with acute thoracolumbar IVDE treated by decompressive hemilaminectomy...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28240957/evaluation-of-gene-expression-and-dna-copy-number-profiles-of-adipose-tissue-derived-stromal-cells-and-consecutive-neurosphere-like-cells-generated-from-dogs-with-naturally-occurring-spinal-cord-injury
#7
Ji-Hey Lim, Sehwon Koh, Rachael Thomas, Matthew Breen, Natasha J Olby
OBJECTIVE To evaluate gene expression and DNA copy number in adipose tissue-derived stromal cells (ADSCs) and in ADSC-derived neurosphere-like cell clusters (ADSC-NSCs) generated from tissues of chronically paraplegic dogs. ANIMALS 14 client-owned paraplegic dogs. PROCEDURES Dorsal subcutaneous adipose tissue (< 1 cm(3)) was collected under general anesthesia; ADSCs were isolated and cultured. Third-passage ADSCs were cultured in neural cell induction medium to generate ADSC-NSCs. Relative gene expression of mesenchymal cell surface marker CD90 and neural progenitor marker nestin was assessed in ADSCs and ADSC-NSCs from 3 dogs by quantitative real-time PCR assay; expression of these and various neural lineage genes was evaluated for the same dogs by reverse transcription PCR assay...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28230415/targeting-translational-successes-through-cansort-sci-using-pet-dogs-to-identify-effective-treatments-for-spinal-cord-injury
#8
Sarah A Moore, Nicolas Granger, Natasha J Olby, Ingo Spitzbarth, Nick D Jeffery, Andrea Tipold, Yvette S Nout-Lomas, Ronaldo C da Costa, Veronika M Stein, Linda J Noble-Haeusslein, Andrew R Blight, Robert G Grossman, D Michele Basso, Jonathan M Levine
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic has been historically challenging, highlighting the need for robust models of injury that more closely mirror the human condition. The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to evaluate expeditiously promising interventions in a population of animals that receive diagnoses and treatment clinically in a manner similar to persons with SCI, while adhering to National Institutes of Health guidelines for scientific rigor and transparent reporting...
June 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27914106/effect-of-cranberry-extract-on-the-frequency-of-bacteriuria-in-dogs-with-acute-thoracolumbar-disk-herniation-a-randomized-controlled-clinical-trial
#9
N J Olby, S L Vaden, K Williams, E H Griffith, T Harris, C L Mariani, K R Muñana, P J Early, S R Platt, L Boozer, C Giovanella, R Longshore
BACKGROUND: Dogs with spinal cord injury are at increased risk of developing bacteriuria due to increased residual urine volume. Cranberry extract inhibits binding of E. coli to uroepithelial cells, potentially reducing risk of bacteriuria. HYPOTHESIS: Cranberry extract reduces risk of bacteriuria in dogs after acute TL-IVDH. ANIMALS: Client-owned dogs with acute onset TL-IVDH causing nonambulatory status. METHODS: Randomized, placebo-controlled, blinded, prospective clinical trial...
January 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27684963/how-can-educators-support-general-practice-gp-trainees-to-develop-resilience-to-prevent-burnout
#10
Bryony Sales, Alexandra Macdonald, Samantha Scallan, Sue Crane
CONTEXT: Burnout impacts adversely on professional and personal life, and holds implications for patient care. Current research on burnout mainly focuses on established general practitioners but it is unclear how early the signs of burnout really start. This work seeks to identify whether specific GP trainee groups are particularly at risk of burnout and the aspects of training they find stressful. METHODS: A longitudinal cohort study, collecting qualitative and quantitative data through a single mode of data collection (questionnaire) took place with trainees from all GP training years (ST1-3), across a vocational training scheme (n = 48)...
November 2016: Education for Primary Care
https://www.readbyqxmd.com/read/27682506/clinical-characteristics-of-canine-fibrocartilaginous-embolic-myelopathy-fce-a-systematic-review-of-393-cases-1973-2013
#11
REVIEW
K A Bartholomew, K E Stover, N J Olby, S A Moore
Fibrocartilaginous embolic myelopathy (FCE) is common in dogs; however, there is conflicting information in the veterinary literature regarding clinical characteristics and data on recovery in severe cases is sparse. A systematic review of canine FCE was performed to delineate the natural history of this disease. 322 previously reported cases and 71 previously unreported cases were identified for inclusion. Source publications were identified via PubMed central search and by references from review articles...
December 24, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27668589/generation-of-pure-cultures-of-autologous-schwann-cells-by-use-of-biopsy-specimens-of-the-dorsal-cutaneous-branches-of-the-cervical-nerves-of-young-adult-dogs
#12
Ji-Hey Lim, Natasha J Olby
OBJECTIVE To identify an optimal technique for isolation, purification, and amplification of Schwann cells (SCs) from biopsy specimens of the dorsal cutaneous branches of the cervical nerves of dogs. SAMPLE Biopsy specimens of dorsal cervical cutaneous nerves from the cadavers of three 1- to 2-year-old dogs. PROCEDURES Nerve specimens were dissected, predegenerated, and dissociated to isolate single cells. After culture to enhance SC growth, cells were immunopurified by use of magnetic beads. Cell purity was evaluated by assessing expression of cell surface antigens p75 (to detect SCs) and CD90 (to detect fibroblasts)...
October 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27616749/clinical-and-diagnostic-imaging-features-of-brain-herniation-in-dogs-and-cats
#13
M J Lewis, N J Olby, P J Early, C L Mariani, K R Muñana, G S Seiler, E H Griffith
BACKGROUND: Quantification of brain herniation on MRI and its immediate clinical implications are poorly described. OBJECTIVES: Define the normal position of caudal fossa structures on brain MRIs in dogs and cats utilizing morphometry, compare this to dogs and cats with caudal transtentorial herniation (CTH), foramen magnum herniation (FMH) or both identified on MRI, and investigate associations between herniation severity, clinical signs, and 24-hour outcome. ANIMALS: Ninety-two controls (66 dogs, 26 cats), 119 cases with herniation (88 dogs, 31 cats)...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27311874/longitudinal-study-of-the-relationship-among-craniocervical-morphology-clinical-progression-and-syringomyelia-in-a-cohort-of-cavalier-king-charles-spaniels
#14
S Cerda-Gonzalez, N J Olby, E H Griffith
BACKGROUND: Craniocervical junction (CCJ) anomalies and secondary syringomyelia are commonly diagnosed in Cavalier King Charles spaniel (CKCS). Familiarity with the natural history of these abnormalities is vital to understanding the disease syndrome. OBJECTIVE: To evaluate magnetic resonance imaging (MRI) predictors of worsening clinical signs, syringomyelia, and morphology in CKCS longitudinally. ANIMALS: Fifty-four client-owned CKCS, 5-13 years old; 50% currently symptomatic...
July 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27240917/recovery-of-stepping-and-coordination-in-dogs-following-acute-thoracolumbar-intervertebral-disc-herniations
#15
C A Rousse, N J Olby, K Williams, T L Harris, E H Griffith, C L Mariani, K R Muñana, P J Early
Prospective data on the recovery of coordination in dogs suffering acute thoracolumbar intervertebral disc herniations (TL-IVDH) are limited. The purpose of this study was to use treadmill based and open field scores (OFS) to quantify recovery of stepping ability and forelimb, hindlimb coordination in the 6 weeks following surgical decompression of dogs with TL-IVDH. Sixty-three dogs were grouped at presentation as grades 3 (non-ambulatory paraparetic), 4 (paraplegic) or 5 (paraplegic without pain sensation) and were evaluated 2, 4, and 6 weeks post-operatively...
July 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27044717/-psychometric-properties-of-the-polish-version-of-the-oldenburg-burnout-inventory-olbi
#16
Łukasz Baka, Beata A Basińska
BACKGROUND: The objective of this study was to test the psychometric properties of the Polish version of the Oldenburg Burnout Inventory (OLBI) - its factor structure, reliability, validity and standard norms. MATERIAL AND METHODS: The study was conducted on 3 independent samples of 1804, 366 and 48 workers employed in social service and general service professions. To test the OLBI structure the exploratory factor analysis was conducted. The reliability was assessed by means of Cronbach's α coefficient (the internal consistent) and test-retest (the stability over time) method, with a 6-week follow-up...
2016: Medycyna Pracy
https://www.readbyqxmd.com/read/27000651/acute-change-in-neurological-level-following-canine-intervertebral-disc-herniation
#17
A Castel, N J Olby
No abstract text is available yet for this article.
April 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/26945915/mechanical-and-thermal-sensory-testing-in-normal-chondrodystrophoid-dogs-and-dogs-with-spinal-cord-injury-caused-by-thoracolumbar-intervertebral-disc-herniations
#18
A M Gorney, S R Blau, C S Dohse, E H Griffith, K D Williams, J-H Lim, D Knazovicky, B D X Lascelles, N J Olby
BACKGROUND: Intervertebral disc herniation is a common cause of spinal cord injury (SCI) causing paralysis and sensory loss. Little quantitative information is available on the loss and recovery of sensation in dogs with SCI. OBJECTIVES: To determine whether quantitative sensory testing (QST) can be used to establish thermal and mechanical sensory thresholds in chrondrodystrophoid dogs and compare thresholds among normal dogs and dogs with different grades of SCI...
March 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/26711123/evaluation-of-a-dla-79-allele-associated-with-multiple-immune-mediated-diseases-in-dogs
#19
Steven G Friedenberg, Greg Buhrman, Lhoucine Chdid, Natasha J Olby, Thierry Olivry, Julien Guillaumin, Theresa O'Toole, Robert Goggs, Lorna J Kennedy, Robert B Rose, Kathryn M Meurs
Immune-mediated diseases are common and life-threatening disorders in dogs. Many canine immune-mediated diseases have strong breed predispositions and are believed to be inherited. However, the genetic mutations that cause these diseases are mostly unknown. As many immune-mediated diseases in humans share polymorphisms among a common set of genes, we conducted a candidate gene study of 15 of these genes across four immune-mediated diseases (immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, immune-mediated polyarthritis (IMPA), and atopic dermatitis) in 195 affected and 206 unaffected dogs to assess whether causative or predictive polymorphisms might exist in similar genes in dogs...
March 2016: Immunogenetics
https://www.readbyqxmd.com/read/26623216/burnout-and-sleep-quality-a-cross-sectional-questionnaire-based-study-of-medical-and-non-medical-students-in-india
#20
Rohan Shad, Rajat Thawani, Ashish Goel
Introduction It is well documented that on entering college, students experience a multitude of changes in sleep habits. Very few studies have been conducted that explore sleep quality in Indian undergraduate students; fewer still study the effects of burnout in the same population. Medical students, in particular, are believed to be more stressed, sleep deprived, and burnt out than their non-medical peers. Methods A cross-sectional study was conducted to study sleep disturbances and burnout in a sample of 214 Indian undergraduate students (112 medical, 102 non-medical)...
2015: Curēus
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