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JOURNAL ARTICLE
Martin Kloub, Pavel Látal, Peter Giannoudis
A narrative review of the literature was conducted to examine the data on femoral head fractures, with a particular focus on their management, complications and clinical outcomes. A PRISMA strategy was used. Medline and Scopus library databases were queried using pre-defined MeSH terms and Boolean operators. Quality of evidence was evaluated based on OCEBM and GRADE systems. The 50 eligible articles that met the predefined inclusion criteria reported on 1403 femoral head fractures. A detailed analysis of the surgical approaches used was performed in 38 articles with 856 fractures...
March 5, 2024: Injury
#22
JOURNAL ARTICLE
Marc Aubreville, Nikolas Stathonikos, Taryn A Donovan, Robert Klopfleisch, Jonas Ammeling, Jonathan Ganz, Frauke Wilm, Mitko Veta, Samir Jabari, Markus Eckstein, Jonas Annuscheit, Christian Krumnow, Engin Bozaba, Sercan Çayır, Hongyan Gu, Xiang 'Anthony' Chen, Mostafa Jahanifar, Adam Shephard, Satoshi Kondo, Satoshi Kasai, Sujatha Kotte, V G Saipradeep, Maxime W Lafarge, Viktor H Koelzer, Ziyue Wang, Yongbing Zhang, Sen Yang, Xiyue Wang, Katharina Breininger, Christof A Bertram
Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in image representations. Considerable covariate shifts occur when assessment is performed on different tumor types, images are acquired using different digitization devices, or specimens are produced in different laboratories. This observation motivated the inception of the 2022 challenge on MItosis Domain Generalization (MIDOG 2022)...
March 22, 2024: Medical Image Analysis
#23
JOURNAL ARTICLE
Sebastian Ayala, Orode Badakhsh, David Li, Neal W Fleming
BACKGROUND: Abnormal diastolic function is an independent predictor of adverse postoperative outcomes. Mitral annular tissue Doppler velocity (e') is a key parameter for assessing diastolic function. The purpose of this study was to confirm that an acute increase in preload did not significantly impact the intraoperative measurement of e' and secondarily evaluate the impact of this acute intravascular volume increase on the clinical assessment of diastolic function using a previously described simplified algorithm...
March 26, 2024: BMC Anesthesiology
#24
JOURNAL ARTICLE
John T Blake, Kathy Ganz, Matthew Seftel, David Allan
BACKGROUND AND OBJECTIVES: When a haematopoietic stem cell registry size is constrained by limits on recruiting, as in Canada, identifying the right person to recruit is a critical determinant of effectiveness. The aim of this study was to evaluate the impact of changes to donor recruitment effort, within ethnic groups, on the matching effectiveness of the Canadian registry as it evolves over time. MATERIALS AND METHODS: Simulation methods are applied to create a cohort of donor recruits and patients over a 10-year time horizon...
March 24, 2024: Vox Sanguinis
#25
JOURNAL ARTICLE
Diogo Silva, Thomas Muders, Karin Wodack, Christian Putensen, Steffen Leonhardt, Robert Siepmann, Benjamin Hentze, Sebastian Reinartz
BACKGROUND: To validate pulmonary computed tomography (CT) perfusion in a porcine model by invasive monitoring of cardiac output (CO) using thermodilution method. METHODS: Animals were studied at a single center, using a Swan-Ganz catheter for invasive CO monitoring as a reference. Fifteen pigs were included. Contrast-enhanced CT perfusion of the descending aorta and right and left pulmonary artery was performed. For variation purposes, a balloon catheter was inserted to block the contralateral pulmonary vascular bed; additionally, two increased CO settings were created by intravenous administration of catecholamines...
March 22, 2024: European Radiology Experimental
#26
JOURNAL ARTICLE
Marc Ganz, Christopher Alessandro, Menachem Jacobs, Yehuda Gejerman, Daniel Miller, Frederick Okoye, Scott Jamieson, Andrew Winer
Introduction Prostate cancer and hepatitis C virus (HCV) infection stand as notable worldwide health issues. Investigating the connection between HCV infection and the risk of prostate cancer remains an ongoing endeavor, complicated by contradictory findings in prior research. It is imperative to comprehend this potential relationship in order to enhance strategies for prevention and treatment. This paper seeks to delve into the association between HCV infection and prostate cancer by analyzing data from the National Health and Nutrition Examination Survey (NHANES), a comprehensive cross-section of the US population...
February 2024: Curēus
#27
Vanessa M Ferreira, Dayane Nunes Rodrigues, Carlos Alberto Mendez Contreras, João M Rossi, Rui Fernando Ramos, Gustavo Oliveira, Mayron F Oliveira
This case report describes the exercise program on a hospitalized 54-year-old male patient with cardiogenic shock waiting for a heart transplant assisted by an intra-aortic balloon pump, a temporary mechanical circulatory support device. The temporary mechanical circulatory support device, an intra-aortic balloon pump, was placed in the left subclavian artery, enabling the exercise protocol. Measurements and values from Swan-Ganz catheter, blood sample, brain natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hs-CRP), as well as the six-minute walk test (6MWT) and venous oxygen saturation (SvO2) were obtained before and after an exercise protocol...
2024: Arquivos Brasileiros de Cardiologia
#28
JOURNAL ARTICLE
Javier Ganz, Lovelace J Luquette, Sara Bizzotto, Michael B Miller, Zinan Zhou, Craig L Bohrson, Hu Jin, Antuan V Tran, Vinayak V Viswanadham, Gannon McDonough, Katherine Brown, Yasmine Chahine, Brian Chhouk, Alon Galor, Peter J Park, Christopher A Walsh
Characterizing somatic mutations in the brain is important for disentangling the complex mechanisms of aging, yet little is known about mutational patterns in different brain cell types. Here, we performed whole-genome sequencing (WGS) of 86 single oligodendrocytes, 20 mixed glia, and 56 single neurons from neurotypical individuals spanning 0.4-104 years of age and identified >92,000 somatic single-nucleotide variants (sSNVs) and small insertions/deletions (indels). Although both cell types accumulate somatic mutations linearly with age, oligodendrocytes accumulated sSNVs 81% faster than neurons and indels 28% slower than neurons...
March 11, 2024: Cell
#29
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington de Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel de la Hoya, Anna deFazio, Allison DePersia, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah
BACKGROUND: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA), UK Biobank (UKBB), and FinnGen to identify novel HGSOC susceptibility loci and develop polygenic scores (PGS). METHODS: We analyzed >22 million variants for 398,238 women. Associations were assessed separately by consortium and meta-analysed...
March 4, 2024: medRxiv
#30
Jessica K Jensen, Ollie Ganz, Marisa Tomaino, Allison M Glasser, Kymberle Sterling, Cristine D Delnevo, Michelle T Bover Manderski
BACKGROUND: The use of cigars for blunts (i.e., cannabis rolled in cigar paper) is well-documented; proportions of cigar and blunt use and associated characteristics are less studied. METHODS: Pooled data from the 2015-2019 National Survey on Drug Use and Health (NSDUH) were analyzed in 2023. Respondents aged 12+ who reported past 30-day cigar use were categorized into three mutually exclusive use categories: (1) exclusively cigars, (2) exclusively blunts, and (3) both cigars and blunts...
February 27, 2024: medRxiv
#31
JOURNAL ARTICLE
Ollie Ganz, Melanie LaVake, Mary Hrywna, Jessica L King Jensen, Cristine D Delnevo
No abstract text is available yet for this article.
March 4, 2024: JAMA Network Open
#32
JOURNAL ARTICLE
Akhila Vadivelan, Sarah Zhang, Daniel N Srole, Elizabeth A Marcus, George Carvalho Neto, Elizabeta Nemeth, Tomas Ganz, Satiro De Oliveira
No abstract text is available yet for this article.
March 7, 2024: Haematologica
#33
Amit D Raval, Michael L Ganz, Kathy Fraeman, Andrea L Lorden, Shanmugapriya Saravanan, Yuexin Tang, Carlos A Q Santos
[This corrects the article DOI: 10.3389/ti.2022.10528.][This corrects the article DOI: 10.3389/ti.2023.12367.].
2024: Transplant International
#34
JOURNAL ARTICLE
Roubina Honarchian, Tracy Yen, Eva Ganz, Gie Kang
OBJECTIVES: The objective of this study was to determine the prevalence of Toxoplasma gondii IgM and IgG positive cats in Los Angeles County, California. T gondii antibodies are common in sera from cats in most reported studies around the world. Although the majority of infected cats never develop clinical disease, development of acute infection and recrudescence of latent infection secondary to immunosuppression has been reported. Knowledge of the serologic status of T gondii may be important when considering immunosuppressive treatments...
2024: JFMS Open Reports
#35
JOURNAL ARTICLE
Comparison of subcritical growth parameters of a Y-TZP obtained via cyclic or dynamic fatigue tests.
Karen Akemi Fukushima, Abdulaziz Alhotan, Sahar Ganz Riman, Gaurav Joshi, Yuanyuan Duan, Jason A Griggs, Paulo Francisco Cesar
OBJECTIVE: The objective of this study was to 1) compare the stress corrosion coefficient (n) of a Y-TZP obtained by two fatigue tests: cyclic and dynamic and 2) evaluate the effect of frequency in the characteristic lifetime and the existence of interaction between the cyclic fatigue and slow crack growth. METHODS: A total of 145 Y-TZP specimens were produced in accordance with the manufacturer's instructions. These specimens, measuring 4.0 × 3.0 × 25...
February 27, 2024: Dental Materials
#36
JOURNAL ARTICLE
Caitlin Weiger, Stefanie K Gratale, Ollie Ganz, Olivia A Wackowski
INTRODUCTION: The 2017 agreement between the U.S. Food and Drug Administration and the makers of Natural America Spirit (NAS) cigarettes restricted use of "additive-free" (AF) in brand marketing, which the company replaced with "tobacco ingredients: tobacco & water" (TW), a phrase subsequently adopted by L&M. We tested how participants' perceptions differed when exposed to AF versus TW claims on NAS and L&M packs. METHODS: A between-subjects experiment was embedded within an online survey in August 2022 (n= 2,526)...
February 28, 2024: Nicotine & Tobacco Research
#37
JOURNAL ARTICLE
Randy M Cohn, Maximillian P Ganz, Giles R Scuderi
Testosterone replacement therapy (TRT) is an indicated treatment of several medical conditions including late-onset hypogonadism, congenital syndromes, and gender affirmation hormonal therapy. Increasing population age, medical benefits, and public awareness of TRT have resulted in increased prevalence of its utilization. However, TRT is not without concern for adverse risks including venous thromboembolic complications, cardiovascular events, and prostate issues. In the field of orthopaedic surgery, research is beginning to delineate the complex relationship between TRT and the development of orthopaedic conditions and potential effects on surgical interventions and outcomes...
April 15, 2024: Journal of the American Academy of Orthopaedic Surgeons
#38
JOURNAL ARTICLE
Lindsay M Forbes, Todd M Bull, Tim Lahm, Tyler Sisson, Katie O'Gean, Justin S Lawley, Kendall Hunter, Benjamin D Levine, Andrew Lovering, Robert C Roach, Andrew W Subudhi, William K Cornwell
Acute hypoxia increases pulmonary arterial (PA) pressures, though its effect on right ventricular (RV) function is controversial. The objective of this study was to characterize exertional RV performance during acute hypoxia. Ten healthy participants (34 ± 10 years, 7 males) completed three visits: visits 1 and 2 included non-invasive normoxic (fraction of inspired oxygen ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:msub><mml:mi>F</mml:mi> <mml:mrow><mml:mi>i</mml:mi> <mml:msub><mml:mi>O</mml:mi> <mml:mn>2</mml:mn></mml:msub> </mml:mrow> </mml:msub> <mml:annotation>${F_{{\mathrm{i}}{{\mathrm{O}}_{\mathrm{2}}}}}$</mml:annotation></mml:semantics> </mml:math> ) = 0...
February 26, 2024: Journal of Physiology
#39
JOURNAL ARTICLE
Shilpa Sharma, Ronit Katz, Paulo H M Chaves, Andrew N Hoofnagle, Jorge R Kizer, Nisha Bansal, Tomas Ganz, Joachim H Ix
AIMS: Among persons with prevalent heart failure (HF), iron deficiency has been linked to HF admissions, and intravenous iron replacement improves HF outcomes. Recent studies in persons with chronic kidney disease (CKD) demonstrate that iron deficiency is associated with incident HF. This study aimed to determine the relationship of iron status with incident HF in community-dwelling older adults irrespective of their kidney function. METHODS: In this case-cohort study, 1,006 Cardiovascular Health Study participants (785 from the random sub-cohort [including 193 HF cases] and 221 additional HF cases [N = 414 total HF cases]) aged ≥ 65 years without HF (41% with CKD), we used weighted Cox models to evaluate associations of iron status with incident HF...
February 26, 2024: ESC Heart Failure
#40
REVIEW
Oswaldo L Castro, Lucia De Franceschi, Tomas Ganz, Julie Kanter, Gregory J Kato, Sant-Rayn Pasricha, Stefano Rivella, John C Wood
Primum non nocere! Can iron deficiency, an abnormality that causes anemia, benefit people with sickle cell disease (SCD) who already have an anemia? The published literature we review appears to answer this question in the affirmative: basic science considerations, animal model experiments, and noncontrolled clinical observations all suggest a therapeutic potential of iron restriction in SCD. This is because SCD's clinical manifestations are ultimately attributable to the polymerization of hemoglobin S (HbS), a process strongly influenced by intracellular HbS concentration...
February 23, 2024: American Journal of Hematology
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