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https://www.readbyqxmd.com/read/29019269/the-burden-of-severe-hypoglycemia-in-type-1-diabetes
#1
Jieruo Liu, Rosa Wang, Michael L Ganz, Yurek Paprocki, Doron Schneider, James Weatherall
AIMS: Approximately 1.25 million people in the United States have type 1 diabetes mellitus (T1DM), a chronic metabolic disease that develops from the body's inability to produce insulin, and requires life-long insulin therapy. Poor insulin adherence may cause severe hypoglycemia (SHO), leading to hospitalization and long-term complications; these, in turn, drive up costs of SHO and T1DM overall. This study's objective was to estimate the prevalence and costs of SHO-related hospitalizations and their additional longer-term impacts on patients with T1DM using basal-bolus insulin...
October 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29017368/the-burden-of-severe-hypoglycemia-in-type-2-diabetes
#2
Jieruo Liu, Rosa Wang, Michael L Ganz, Yurek Paprocki, Doron Schneider, James Weatherall
AIMS: More than 29 million people in the United States have type 2 diabetes mellitus (T2DM), a chronic metabolic disorder characterised by a progressive deterioration of glucose control, which eventually requires insulin. Abnormally low levels of blood glucose, a feared side effect of insulin treatment, may cause severe hypoglycemia (SHO), leading to emergency department (ED) admission, hospitalization, and long-term complications; these, in turn, drive up the costs of T2DM. This study's objective was to estimate the prevalence and costs of SHO-related hospitalizations and their additional longer-term impact on patients with T2DM using insulin...
October 11, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28991900/intra-individual-variability-and-circadian-rhythm-of-vascular-endothelial-growth-factors-in-subjects-with-normal-glucose-tolerance-and-type-2-diabetes
#3
Markolf Hanefeld, Katrin Engelmann, Dieter Appelt, Dirk Sandner, Ingo Weigmann, Xenia Ganz, Frank Pistrosch, Carsta Köhler, Antje Gasparic, Andreas L Birkenfeld
Increased levels of systemic vascular endothelial growth factors (VEGFs) in patients with diabetes are associated with increased risk of microvessel disease. On the other hand, low VEGF levels after intravitreal antibody application may be associated with acute cardiovascular complications and treatment failure. Individual levels of systemic VEGF vary in a wide range depending on analytical methods and quality of diabetes control. So far only limited information exists on intraindividual fluctuations over longer periods and circadian rhythms...
2017: PloS One
https://www.readbyqxmd.com/read/28985586/effects-of-a-stand-alone-web-based-electronic-screening-and-brief-intervention-targeting-alcohol-use-in-university-students-of-legal-drinking-age-a-randomized-controlled-trial
#4
Thomas Ganz, Michael Braun, Marion Laging, Karin Schermelleh-Engel, Johannes Michalak, Thomas Heidenreich
BACKGROUND: Many intervention efforts targeting student drinking were developed to address US college students, which usually involves underage drinking. It remains unclear, if research evidence from these interventions is generalizable to university and college students of legal drinking age, e.g., in Europe. OBJECTIVE: To evaluate the effectiveness of a translated and adapted version of the eCHECKUP TO GO, applied as stand-alone web-based electronic screening and brief intervention (e-SBI), in German university students at risk for hazardous drinking...
September 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28975691/gut-feelings-studying-enteric-nervous-system-development-function-and-disease-in-the-zebrafish-model-system
#5
REVIEW
Julia Ganz
The enteric nervous system (ENS) is the largest part of the peripheral nervous system and is entirely neural crest derived. It provides the intrinsic innervation of the gut controlling different aspects of gut function, such as motility. In this review, we will discuss key points of zebrafish ENS development, genes and signaling pathways regulating ENS development as well as contributions of the zebrafish model system to better understand ENS disorders. During their migration, enteric progenitor cells display a gradient of developmental states based on their proliferative and migratory characteristics and show spatio-temporal heterogeneity based on gene expression patterns...
October 4, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28974520/improving-assessment-of-drug-safety-through-proteomics-early-detection-and-mechanistic-characterization-of-the-unforeseen-harmful-effects-of-torcetrapib
#6
Stephen A Williams, Ashwin C Murthy, Robert K DeLisle, Craig Hyde, Anders Malarstig, Rachel Ostroff, Sophie J Weiss, Mark R Segal, Peter Ganz
Background -Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINATE, a trial of torcetrapib (a cholesterol ester transfer protein inhibitor), that involved 15,067 participants at high cardiovascular risk. ILLUMINATE was terminated at a median of 550 days due to significant absolute increases of 1.2% in cardiovascular events and 0...
October 3, 2017: Circulation
https://www.readbyqxmd.com/read/28971032/the-pulmonary-artery-catheter-in-2008-a-finally-maturing-modality
#7
REVIEW
Stanislaw P Stawicki, Mark P Prosciak
The first description of the flow-directed pulmonary artery catheter (PAC) was published in the 1970s by Jeremy Swan and William Ganz. Ever since its clinical debut, many controversies surrounded the use of the PAC. Regardless of these controversies, the most fundamental issues surrounding this hemodynamic monitoring device remain unresolved, including the exact indications, contraindications, identification of patients who potentially benefit from this technology, and the way we interpret and use PAC-derived parameters...
July 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28970005/different-cochleovestibular-manifestations-and-outcomes-in-patients-diagnosed-with-dengue
#8
Isabella Marques Pereira Rahme, Geraldo Majela Pereira, Tanit Ganz Sanchez
No abstract text is available yet for this article.
September 19, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28958203/using-implementation-tools-to-design-and-conduct-quality-improvement-projects-for-faster-and-more-effective-improvement
#9
John Ovretveit, Brian Mittman, Lisa Rubenstein, David A Ganz
Purpose The purpose of this paper is to enable improvers to use recent knowledge from implementation science to carry out improvement changes more effectively. It also highlights the importance of converting research findings into practical tools and guidance for improvers so as to make research easier to apply in practice. Design/methodology/approach This study provides an illustration of how a quality improvement (QI) team project can make use of recent findings from implementation research so as to make their improvement changes more effective and sustainable...
October 9, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28957553/disease-activity-dynamics-in-rheumatoid-arthritis-patients-self-assessment-of-disease-activity-via-webapp
#10
MULTICENTER STUDY
Ulrich A Walker, Ruediger B Mueller, Veronika K Jaeger, Robert Theiler, Adrian Forster, Patrick Dufner, Fabiana Ganz, Diego Kyburz
Objectives: The aim was to evaluate patient self-assessment of RA disease activity in terms of Routine Assessment of Patient Index Data (RAPID) scores via a Web-based smartphone application (WebApp). Methods: In this prospective, multicentre study, adult RA patients were examined by a rheumatologist at baseline and after 3 months. Patients were asked to complete WebApp questionnaires weekly. The time course of patient-assessed RAPID3/4 scores and their correlations with rheumatologist-assessed DAS28, as well as Clinical and Simplified Disease Activity Indices (CDAI/SDAI), were evaluated...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28954297/long-term-peripheral-neuropathy-in-breast-cancer-patients-treated-with-adjuvant-chemotherapy-nrg-oncology-nsabp-b-30
#11
RANDOMIZED CONTROLLED TRIAL
Hanna Bandos, Joy Melnikow, Donna R Rivera, Sandra M Swain, Keren Sturtz, Louis Fehrenbacher, James L Wade, Adam M Brufsky, Thomas B Julian, Richard G Margolese, Edward C McCarron, Patricia A Ganz
Background: The long-term effects of chemotherapy are sparsely reported. Peripheral neuropathy (PN) is one of the most frequent toxicities associated with taxane use for the treatment of early-stage breast cancer. We investigated the impact of the three different docetaxel-based regimens and patient characteristics on long-term, patient-reported outcomes of PN and the impact of PN on long-term quality of life (QOL). Methods: The National Surgical Adjuvant Breast and Bowel Project Protocol B-30 was a randomized trial comparing sequential doxorubicin (A) and cyclophosphamide (C) followed by docetaxel (T) (AC→T), concurrent ACT, or AT in women with node-positive, early-stage breast cancer...
February 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28954296/chemotherapy-associated-peripheral-neuropathy-in-patients-with-early-stage-breast-cancer-a-systematic-review
#12
REVIEW
Donna R Rivera, Patricia A Ganz, Meghan S Weyrich, Hanna Bandos, Joy Melnikow
Breast cancer is the most common cancer among women worldwide, and survival rates are increasing. Chemotherapy-associated peripheral neuropathy (PN) is clinically important because of effects on quality of life (QOL) and potential effects on dose limitations. This adverse drug reaction is associated with certain classes of chemotherapy and commonly presents as peripheral sensory neuropathy whose natural course is largely unknown. The literature was reviewed to determine the frequency and characteristics of PN associated with adjuvant chemotherapy in early-stage breast cancer (ESBC) to explore the potential impact on long-term (one or more years after diagnosis) health outcomes and QOL...
February 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28928285/correction-distinct-roles-of-neuroepithelial-like-and-radial-glia-like-progenitor-cells-in-cerebellar-regeneration
#13
Jan Kaslin, Volker Kroehne, Julia Ganz, Stefan Hans, Michael Brand
No abstract text is available yet for this article.
September 15, 2017: Development
https://www.readbyqxmd.com/read/28927216/letter-transarterial-n-butyl-2-cyanoacrylate-embolization-of-an-intraosseous-dural-arteriovenous-fistula-associated-with-acute-epidural-hematoma-technical-case-report
#14
Jeremy C Ganz
No abstract text is available yet for this article.
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28923751/effects-of-mindfulness-training-on-emotional-and-physiologic-recovery-from-induced-negative-affect
#15
Alexandra D Crosswell, Patricia I Moreno, Elizabeth B Raposa, Sarosh J Motivala, Annette L Stanton, Patricia A Ganz, Julienne E Bower
OBJECTIVE: Mindfulness training has been shown to improve psychological well-being and physical health. One proposed pathway for the positive effects of mindfulness training is through the development of new emotion regulation strategies, such as the ability to experience emotions by observing and accepting them without judgment. Theoretically, this should facilitate recovery from negative emotional states; however, this has rarely been examined empirically. The goal of the current study was to determine whether mindfulness training is associated with more efficient emotional and cardiovascular recovery from induced negative affect...
August 4, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28922953/high-technology-augmentative-and-alternative-communication-for-individuals-with-intellectual-and-developmental-disabilities-and-complex-communication-needs-a-meta-analysis
#16
Jennifer B Ganz, Kristi L Morin, Margaret J Foster, Kimberly J Vannest, Derya Genç Tosun, Emily V Gregori, Stephanie L Gerow
The use of mobile technology is ubiquitous in modern society and is rapidly increasing in novel use. The use of mobile devices and software applications ("apps") as augmentative and alternative communication (AAC) is rapidly expanding in the community, and this is also reflected in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC, including mobile devices, by individuals with intellectual and developmental disabilities, including autism spectrum disorder...
September 19, 2017: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/28920095/computational-study-of-quasi-2d-liquid-state-in-free-standing-platinum-silver-gold-and-copper-monolayers
#17
Li-Ming Yang, Ariel B Ganz, Matthew Dornfeld, Eric Ganz
Recently, freestanding atomically thick Fe metal patches up to 10 atoms wide have been fabricated experimentally in tiny pores in graphene. This concept can be extended conceptually to extended freestanding monolayers. We have therefore performed ab initio molecular dynamics simulations to evaluate the early melting stages of platinum, silver, gold, and copper freestanding metal monolayers. Our calculations show that all four freestanding monolayers will form quasi-2D liquid layers with significant out-of-plane motion and diffusion in the plane...
December 2016: Condens Matter
https://www.readbyqxmd.com/read/28888809/childhood-maltreatment-psychological-resources-and-depressive-symptoms-in-women-with-breast-cancer
#18
Kate Ryan Kuhlman, Chloe C Boyle, Michael R Irwin, Patricia A Ganz, Catherine M Crespi, Arash Asher, Laura Petersen, Julienne E Bower
Childhood maltreatment is associated with elevated risk for depression across the human lifespan. Identifying the pathways through which childhood maltreatment relates to depressive symptoms may elucidate intervention targets that have the potential to reduce the lifelong negative health sequelae of maltreatment exposure. In this cross-sectional study, 271 women with early-stage breast cancer were assessed after their diagnosis but before the start of adjuvant treatment (chemotherapy, radiation, endocrine therapy)...
September 7, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28874929/trends-and-characteristics-of-emergency-department-visits-for-fall-related-injuries-in-older-adults-2003-2010
#19
Kalpana N Shankar, Shan W Liu, David A Ganz
INTRODUCTION: One third of older adults fall each year, and falls are costly to both the patient in terms of morbidity and mortality and to the health system. Given that falls are a preventable cause of injury, our objective was to understand the characteristics and trends of emergency department (ED) fall-related visits among older adults. We hypothesize that falls among older adults are increasing and examine potential factors associated with this rise, such as race, ethnicity, gender, insurance and geography...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28838512/severe-tricuspid-regurgitation-after-percutaneous-removal-of-a-swan-ganz-catheter-caught-by-suture
#20
Marco Gennari, Antonio L Bartorelli, Gianluca Polvani, Manuela Muratori, Cristina Ferrari, Eleonora Penza, Francesco G Arlati, Marco Agrifoglio
Swan-Ganz catheter entrapment in the heart, vena cava, or pulmonary artery is rare but may lead to life-threatening events. We report a case of severe tricuspid regurgitation resulting from papillary muscle rupture during percutaneous removal of a Swan-Ganz catheter (SCG) caught by a surgical suture. We performed urgent tricuspid valve repair by suturing the ruptured papillary muscle. This report highlights preventive measures to avoid suture-related entrapment and raises a word of caution regarding percutaneous removal of accidentally entrapped SCGs...
September 2017: Annals of Thoracic Surgery
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