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https://www.readbyqxmd.com/read/28081463/analysis-of-the-results-of-recurrent-intracranial-meningiomas-treated-with-re-radiosurgery
#1
Moinay Kim, Do Hee Lee, Hyun Jung Kim Rn, Young Hyun Cho, Jeong Hoon Kim, Do Hoon Kwon
OBJECTS: Meningioma is the most common intracranial neoplasm, comprising approximately 30% of all primary intracranial tumors (Claus et al., 2005) [1]. Treatment options include observation, microsurgical resection, stereotactic radiosurgery (SRS), and whole brain radiation therapy (WBRT). Gamma knife radiosurgery (GKRS) is a very effective treatment for intracranial meningiomas; previous studies showed the tumor control rate at 5-10 years of follow-up as 84.3%-100% in all cases (Feigl et al...
December 29, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28075185/cerebellar-heterogeneity-and-its-impact-on-pet-data-quantification-of-5-ht-receptor-radioligands
#2
Melanie Ganz, Ling Feng, Hanne Demant Hansen, Vincent Beliveau, Claus Svarer, Gitte M Knudsen, Douglas N Greve
In the quantification of positron emission tomography (PET) radiotracer binding, a commonly used method is reference tissue modeling (RTM). RTM necessitates a proper reference and a ubiquitous choice for G-protein coupled receptors is the cerebellum. We investigated regional differences in uptake within the grey matter of the cerebellar hemispheres (CH), the cerebellar white matter (CW), and the cerebellar vermis (CV) for five PET radioligands targeting the serotonin system. Furthermore, we evaluated the impact of choosing different reference regions when quantifying neocortical binding...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28065172/incorporating-environmental-outcomes-into-a-health-economic-model
#3
Kevin Marsh, Michael Ganz, Emil Nørtoft, Niels Lund, Joshua Graff-Zivin
OBJECTIVES: Traditional economic evaluations for most health technology assessments (HTAs) have previously not included environmental outcomes. With the growing interest in reducing the environmental impact of human activities, the need to consider how to include environmental outcomes into HTAs has increased. We present a simple method of doing so. METHODS: We adapted an existing clinical-economic model to include environmental outcomes (carbon dioxide [CO2] emissions) to predict the consequences of adding insulin to an oral antidiabetic (OAD) regimen for patients with type 2 diabetes mellitus (T2DM) over 30 years, from the United Kingdom payer perspective...
January 9, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28053252/instability-of-the-hip-after-anatomical-re-alignment-in-patients-with-a-slipped-capital-femoral-epiphysis
#4
A Aprato, M Leunig, A Massé, T Slongo, R Ganz
AIMS: Several studies have reported the safety and efficacy of subcapital re-alignment for patients with slipped capital femoral epiphysis (SCFE) using surgical dislocation of the hip and an extended retinacular flap. Instability of the hip and dislocation as a consequence of this surgery has only recently gained attention. We discuss this problem with some illustrative cases. MATERIALS AND METHODS: We explored the literature on the possible pathophysiological causes and surgical steps associated with the risk of post-operative instability and articular damage...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28053035/a-high-resolution-in-vivo-atlas-of-the-human-brain-s-serotonin-system
#5
Vincent Beliveau, Melanie Ganz, Ling Feng, Brice Ozenne, Liselotte Højgaard, Patrick M Fisher, Claus Svarer, Douglas N Greve, Gitte M Knudsen
: The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28033439/a-standard-set-of-value-based-patient-centered-outcomes-for-breast-cancer-the-international-consortium-for-health-outcomes-measurement-ichom-initiative
#6
Wee Loon Ong, Maartje G Schouwenburg, Annelotte C M van Bommel, Caleb Stowell, Kim H Allison, Karen E Benn, John P Browne, Rodney D Cooter, Geoff P Delaney, Francois P Duhoux, Patricia A Ganz, Patricia Hancock, Reshma Jagsi, Felicia M Knaul, Anne M Knip, Linetta B Koppert, Henry M Kuerer, Sarah McLaughin, Marc A M Mureau, Ann H Partridge, Dereesa Purtell Reid, Lisa Sheeran, Thomas J Smith, Mark J Stoutjesdijk, Marie Jeanne T F D Vrancken Peeters, Yvonne Wengström, Cheng-Har Yip, Christobel Saunders
A major challenge in value-based health care is the lack of standardized health outcomes measurements, hindering optimal monitoring and comparison of the quality of health care across different settings globally. The International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary international working group, comprised of 26 health care providers and patient advocates, to develop a standard set of value-based patient-centered outcomes for breast cancer (BC). The working group convened via 8 teleconferences and completed a follow-up survey after each meeting...
December 29, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/28029322/doctor-now-that-my-chemotherapy-treatment-is-over-when-will-my-chemofog-lift
#7
Kathleen Van Dyk, Patricia A Ganz
No abstract text is available yet for this article.
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28025156/a-modern-magnetic-implant-for-gastroesophageal-reflux-disease-gerd
#8
Robert A Ganz
A magnetic implant for the treatment of GERD was FDA-approved in 2012 and has been extensively evaluated. The device is a ring of magnets, that are placed around the gastroesophageal junction, augmenting the native lower esophageal sphincter and preventing reflux yet preserving LES physiologic function and allowing belching and vomiting. Magnetic force is advantageous, being permanent and precise, and forces between magnets decrease with esophageal displacement. Multiple patient cohorts have been studied using the magnetic device, and trials establish consistent, long-term improvement in pH data, GERD symptom scores and PPI use...
December 23, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28024552/the-swan-ganz-catheter-remains-a-critically-important-component-of-monitoring-in-cardiovascular-critical-care
#9
Matthew Lee, Gerard F Curley, Mary Mustard, C David Mazer
Few inventions in modern medicine have generated as passionate and extended debate as the pulmonary artery catheter (PAC). Since its introduction in 1970, the PAC remains an indispensable monitor in cardiovascular critical care. Despite attempts to develop less invasive alternatives, the PAC remains unequaled as a single monitoring device capable of measuring physiological derangement in most components of the circulation, in the awake or sedated patient, with real-time feedback on the efficacy of an intervention...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28011387/the-kidney-and-periodontal-disease-kapd-study-a-pilot-randomized-controlled-trial-testing-the-effect-of-non-surgical-periodontal-therapy-on-chronic-kidney-disease
#10
Vanessa Grubbs, Faviola Garcia, Bonnie L Jue, Eric Vittinghoff, Mark Ryder, David Lovett, Jacqueline Carrillo, Steven Offenbacher, Peter Ganz, Kirsten Bibbins-Domingo, Neil R Powe
INTRODUCTION: Chronic kidney disease (CKD) remains a prevalent public health problem that disproportionately affects minorities and the poor, despite intense efforts targeting traditional risk factors. Periodontal diseases are common bacterial plaque-induced inflammatory conditions that can respond to treatment and have been implicated as a CKD risk factor. However there is limited evidence that treatment of periodontal disease slows the progression of CKD. METHODS/DESIGN: We describe the protocol of the Kidney and Periodontal Disease (KAPD) study, a 12-month un-blinded, randomized, controlled pilot trial with two intent-to-treat treatment arms: 1...
December 20, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28011046/promoting-the-appropriate-use-of-advanced-radiation-technologies-in-oncology-summary-of-a-national-cancer-policy-forum-workshop
#11
Grace L Smith, Patricia A Ganz, Justin E Bekelman, Steven J Chmura, James J Dignam, Jason A Efstathiou, Reshma Jagsi, Peter A Johnstone, Michael L Steinberg, Stephen B Williams, James B Yu, Anthony L Zietman, Ralph R Weichselbaum, Ya-Chen Tina Shih
PURPOSE: Leaders in the oncology community are sounding a clarion call to promote "value" in cancer care decisions. Value in cancer care considers the clinical effectiveness, along with the costs, when selecting a treatment. To discuss possible solutions to the current obstacles to achieving value in the use of advanced technologies in oncology, the National Cancer Policy Forum of the National Academies of Sciences, Engineering, and Medicine held a workshop, "Appropriate Use of Advanced Technologies for Radiation Therapy and Surgery in Oncology" in July 2015...
November 8, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28002350/in-reply
#12
Allison J Huang, Peter Ganz, Deborah Grady, Steven R Cummings
No abstract text is available yet for this article.
January 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27998918/role-of-t-cell-dysfunction-inflammation-and-coagulation-in-microvascular-disease-in-hiv
#13
Arjun Sinha, Yifei Ma, Rebecca Scherzer, Sophia Hur, Danny Li, Peter Ganz, Steven G Deeks, Priscilla Y Hsue
BACKGROUND: Compared to uninfected adults, HIV-infected adults on antiretroviral therapy are at increased risk of cardiovascular disease. Given the increase in T-cell dysfunction, inflammation, and coagulation in HIV infection, microvascular dysfunction is thought to contribute to this excess cardiovascular risk. However, the relationships between these variables remain undefined. METHODS AND RESULTS: This was a cross-sectional study of 358 HIV-infected adults from the SCOPE cohort...
December 20, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27986365/silicon-dioxide-polyvinylpyrrolidone-as-a-wound-dressing-for-skin-defects-in-a-murine-model
#14
Ferenc Öri, Richard Dietrich, Cornelia Ganz, Michael Dau, Daniel Wolter, Annika Kasten, Thomas Gerber, Bernhard Frerich
OBJECTIVE: There is a high demand for temporary wound dressings that improve wound healing and regeneration. Silicon (as SiO2) has been shown to support the growth and collagen formation in biological systems. METHODS: A nanocomposite was made from PVP (polyvinylpyrrolidon), nano-sized silica aggregates and water and served for fabrication of a wet dressing material (SiO2-PVP gel, by cross-linking the gel) and a freeze-dried dressing material (SiO2-PVP fleece). Materials were characterized by SAXS, DSC, EDX and viscosity measurements...
January 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27979940/draft-genome-sequence-of-enterococcus-faecalis-strain-ucd-pd3
#15
Dana R De Vries, Alexandra L Martin, Holly H Ganz, Jonathan A Eisen, David A Coil
Here, we present the draft genome sequence of Enterococcus faecalis strain UCD-PD3. The assembly contains 2,861,314 bp in 73 contigs. This strain was isolated from a feral domestic cat (Felis catus) anal sac secretion sample, as part of a project on isolating and characterizing the microbes present in feline anal sacs.
December 15, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27926762/association-of-arterial-and-lymph-node-inflammation-with-distinct-inflammatory-pathways-in-human-immunodeficiency-virus-infection
#16
Ahmed Tawakol, Amorina Ishai, Danny Li, Richard A P Takx, Sophia Hur, Yannick Kaiser, Miguel Pampaloni, Adam Rupert, Denise Hsu, Irini Sereti, Rémi Fromentin, Nicolas Chomont, Peter Ganz, Steven G Deeks, Priscilla Y Hsue
Importance: Human immunodeficiency virus (HIV) infection is associated with a high risk of cardiovascular disease and increased arterial inflammation. In HIV, inflammation is also increased within lymph nodes (LNs), tissues known to harbor the virus even among treated and suppressed individuals. Objective: To test the hypothesis that arterial inflammation is linked to HIV disease activity and to inflammation within HIV-infected tissues (LNs). Design, Setting, and Participants: For this case-control study, participants were recruited from the SCOPE (Observational Study of the Consequences of the Protease Inhibitor Era) cohort, a clinic-based cohort of individuals receiving care at San Francisco General Hospital and the San Francisco Veteran's Affairs Medical Center...
December 7, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27922942/letters-to-the-editor
#17
Allison J Huang, Peter Ganz, Deborah Grady, Steven R Cummings
No abstract text is available yet for this article.
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27916185/editorial-commentary-when-is-it-just-a-labral-tear-and-not-femoroacetabular-impingement
#18
EDITORIAL
Paul E Beaulé
How often in medicine do we have a diagnosis or pathology to evaluate and treat that hasn't previously been described? With the introduction of the concept of femoroacetabular impingement in 1999, Ganz and colleagues effectively put forth a not-previously-described diagnosis in the field of orthopaedic surgery that has expanded into the biosphere of musculoskeletal care, where we can find now research on this subject in radiology, rheumatology, biomechanics, biomedical, physical therapy, and sports medicine journals...
December 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27891073/a-hitchhiker-s-guide-to-functional-magnetic-resonance-imaging
#19
REVIEW
José M Soares, Ricardo Magalhães, Pedro S Moreira, Alexandre Sousa, Edward Ganz, Adriana Sampaio, Victor Alves, Paulo Marques, Nuno Sousa
Functional Magnetic Resonance Imaging (fMRI) studies have become increasingly popular both with clinicians and researchers as they are capable of providing unique insights into brain functions. However, multiple technical considerations (ranging from specifics of paradigm design to imaging artifacts, complex protocol definition, and multitude of processing and methods of analysis, as well as intrinsic methodological limitations) must be considered and addressed in order to optimize fMRI analysis and to arrive at the most accurate and grounded interpretation of the data...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27884972/increased-serum-hepcidin-contributes-to-the-anemia-of-chronic-kidney-disease-in-a-murine-model
#20
Mark R Hanudel, Maxime Rappaport, Victoria Gabayan, Grace Jung, Isidro B Salusky, Elizabeta Nemeth, Tomas Ganz, Joshua Zaritsky
No abstract text is available yet for this article.
November 24, 2016: Haematologica
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