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https://www.readbyqxmd.com/read/29166669/frequency-of-five-disease-causing-genetic-mutations-in-a-large-mixed-breed-dog-population-2011-2012
#1
Sharon Zierath, Angela M Hughes, Neale Fretwell, Mark Dibley, Kari J Ekenstedt
BACKGROUND: A large and growing number of inherited genetic disease mutations are now known in the dog. Frequencies of these mutations are typically examined within the breed of discovery, possibly in related breeds, but nearly always in purebred dogs. No report to date has examined the frequencies of specific genetic disease mutations in a large population of mixed-breed dogs. Further, veterinarians and dog owners typically dismiss inherited/genetic diseases as possibilities for health problems in mixed-breed dogs, assuming hybrid vigor will guarantee that single-gene disease mutations are not a cause for concern...
2017: PloS One
https://www.readbyqxmd.com/read/29166571/protective-cerebrovascular-effects-of-hydroxysafflor-yellow-a-hsya-on-ischemic-stroke
#2
Yang Sun, Dong-Ping Xu, Zhen Qin, Peng-Yuan Wang, Bo-Han Hu, Jian-Guang Yu, Yong Zhao, Ben Cai, Yong-Ling Chen, Min Lu, Jian-Guo Liu, Xia Liu
The purpose of the present work was designed to explore protective cerebrovascular effects of hydroxysafflor yellow A (HSYA), and provide preclinical efficacy and mechanism data for its possible application in patients with cerebral ischemia. The protective effect of HSYA on ischemic stroke was evaluated by infarct sizes and neurological scores in Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Cerebrovascular permeability was detected by Evans blue dye leakage in MCAO rats. Cerebral blood flow, as well as blood pressure and heart rate were monitored using flow probes in Beagle dogs...
November 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29166400/chronic-post-traumatic-intramedullary-lesions-in-dogs-a-translational-model
#3
Neringa Alisauskaite, Ingo Spitzbarth, Wolfgang Baumgärtner, Peter Dziallas, Sabine Kramer, Ricarda Dening, Veronika Maria Stein, Andrea Tipold
OBJECTIVES: Post-traumatic intramedullary myelopathies and cavitations are well described lesions following spinal cord injury (SCI) in humans and have been described in histopathological evaluations in dogs. Human intramedullary myelopathies/cavitations are associated with severe initial SCI and deterioration of clinical signs. Canine intervertebral disc extrusions share similarities with SCI in humans. In this descriptive study, magnetic resonance imaging (MRI) findings in spinal cords of dogs suffering from chronic post-traumatic myelopathies, including cavitations, are elucidated...
2017: PloS One
https://www.readbyqxmd.com/read/29166285/an-evaluation-of-the-usefulness-of-invasive-and-non-invasive-methods-used-to-diagnose-helicobacter-spp-infections-in-dogs
#4
M Jankowski, J Spużak, K Kubiak, K Glińska-Suchocka, M Biernat
The aim of this study was to assess the suitability of invasive and non-invasive methods used to diagnose Helicobacter spp. in the stomachs of dogs. The study was carried out on 30 dogs of both sexes and different breeds, between one and 15 years old. A histopathologic examination, a microbiological culture, a rapid urease test, a direct bacteriological preparation and a nested PCR assay were carried out. Gastric Helicobacter spp. was identified in gastric biopsy specimens from 16 (53.3%) dogs using direct bacteriological preparation, in four (13...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166283/cardiac-disorders-in-dogs-infected-with-babesia-canis
#5
M Bartnicki, P Łyp, P Dębiak, M Staniec, S Winiarczyk, K Buczek, Ł Adaszek
The aim of this study was to assess cardiac disorders in dogs infected with B. canis. The study included 50 dogs with babesiosis and 20 healthy control animals. All the animals had haematological tests, ECG, echocardiography and serum troponin I and CK-MB levels checked. The haematology in the group of dogs with babesiosis confirmed thrombocytopaenia in 100% of dogs, decreased haematocrit in 52% and anaemia in 46%. The most common abnormalities in ECG and echocardiography in dogs infected with protozoa included: change in appearance and/or amplitude of the T-wave (34%), increased fractional shortening (24%), an increased sinus rhythm (14%) and heart axis deviation (10%)...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166282/adenocarcinoma-of-the-posterior-segment-of-the-gastrointestinal-tract-in-dogs-clinical-endoscopic-histopathological-and-immunohistochemical-findings
#6
J Spużak, R Ciaputa, K Kubiak, M Jankowski, K Glińska-Suchocka, D Poradowski, M Nowak
Of all the tumours in dogs, three percent are located in the intestines, and 36-60% of those tumours affect the large intestine. Adenocarcinomas of the intestines account for 20-35% of the gastrointestinal tumours and for almost 60% of the large intestine tumours. The aim of the study was to analyze clinical disorders and endoscopic, histopathological and immunohistochemical changes in colorectal adenocarcinomas in dogs with the use of the E-cadherin, β-catenin, cytokeratin 20 (CK20), Ki-67 and minichromosome maintenance 3 (MCM-3)...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166281/epidemiological-study-of-canine-mast-cell-tumours-according-to-the-histological-malignancy-grade
#7
Anna Śmiech, B Ślaska, W Łopuszyński, A Jasik, M Szczepanik, P Wilkołek
The aim of the study was to identify significant relationships between the tumour malignancy grade and dogs' age, breed, sex, size, and location of mast cell tumours (MCTs). MCTs accounted for 13.27% of all diagnosed canine skin tumours. The highest incidence was recorded among Boxers, Labrador Retrievers, American Staffordshire Terriers, and Golden Retrievers. Statistical analysis revealed significantly higher probability of occurrence of the grade I mast cell tumour in the French Bulldog in the head, neck, torso, and limb regions, the grade-II mast cell tumour in Boxer, Doberman, Dachshund, shepherds, and setters in the scrotal region, and the grade III mast cell tumour in Shar-Pei in the axilla region...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166279/influence-of-long-term-oral-application-of-quinolones-on-the-ecg-curve-in-dogs
#8
A Cepiel, A Noszczyk-Nowak, A Cekiera, J Popiel, U Pasławska
The aim of the study was to analyse the influence of enrofloxacin and pradofloxacin administered orally for 14 days on the ECG in dogs. The ECG was performed before and after a 14 day period of quinolone administration. There was an increase in the QTc and the TpTe interval in the group treated with quinolones. QTc was prolonged by 24 ms (p=0.001). The TpTe interval was shortened, on average, by 6.55 ms (p=0.048). In the group treated with enrofloxacin, QTc was prolonged by 16.27 ms (p=0.006) and the TpTe interval was shortened by 9...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166276/comparison-of-body-surface-area-based-and-weight-based-dosing-format-for-oral-prednisolone-administration-in-small-and-large-breed-dogs
#9
A Nam, S M Kim, J W Jeong, K H Song, T S Koo, K W Seo
This study compared the pharmacokinetics of Prednisolone (PDS) in small- and large breed dogs with a dosing format based on body surface area (BSA) or body weight (BW). The maximum concentration and area under the curve in large-breed dogs orally administered 2 mg/kg PDS were significantly greater than those in small-breed dogs given 2 mg/kg and in large-breed dogs given 40 mg/m2. The higher blood concentrations that result from BW-based dosing of oral PDS in large-breed dogs can be more than required for effect...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166267/comparison-of-the-two-types-of-stimulating-electrodes-in-the-study-of-motor-nerve-conduction-in-dogs
#10
T Monowid, A Bocheńska, S Lew, A Pomianowski
In this research two kinds of stimulation electrodes were compared in motor nerve conduction study: needle electrodes used in human medicine and electrodes made of injection needles connected to the stimulator via alligator-type electrodes. A study was conducted in 22 mixed-breed dogs. The resulting values of the potential amplitudes of the stimulus, the parameters of the complex muscle potentials, and the motor nerve conduction velocity were statistically compared. There was no statistical difference between the parameters obtained with the two types of stimulation electrodes...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166257/raoultella-planticola-a-rare-cause-of-wound-infection
#11
Shana S Kalaria, Kristina Elliott, Neal Combs, Linda G Phillips
Raoultella planticola is a gram-negative, aerobic, rod bacterium commonly found in the environment, particularly in water, soil, and fish. This organism has been found to cause a variety of infections, such as necrotizing fasciitis, cystitis, cholecystitis, pancreatitis, hepatic disease, and soft tissue infections. The authors report the case of a 73-year-old-woman who presented with a R planticola wound infection of her left lower extremity after a dog scratch. She was treated successfully with local wound care using dehydrated human amnion/chorion and oral levofloxacin...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29166020/solid-digestion-of-demineralized-bone-as-a-method-to-access-potentially-insoluble-proteins-and-post-translational-modifications
#12
Timothy P Cleland
Bone proteomics is an expanding field for understanding protein changes associated with disease as well as characterizing and detecting proteins preserved in fossil bone. Most previous studies have utilized a protocol with demineralization and extraction approach to isolate and characterize proteins from bone. Through near-complete EDTA demineralization, followed by solid digestion of the remaining bone pseudomorph, a total of 92 protein accessions were detected from dog bone. In the EDTA, 14 unique proteins were found, including osteocalcin, an important bone protein...
November 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29165910/retrospective-evaluation-of-the-prognostic-utility-of-plasma-lactate-concentration-base-deficit-ph-and-anion-gap-in-canine-and-feline-emergency-patients
#13
Casey J Kohen, Kate Hopper, Philip H Kass, Steven E Epstein
OBJECTIVE: To determine the association of plasma lactate concentration, pH, base deficit (BD), and anion gap (AG) in dogs and cats on presentation to an emergency room with outcome, and to compare the prognostic significance of hyperlactatemia with a concurrent metabolic acidosis with that of hyperlactatemia and a normal metabolic acid-base balance. DESIGN: Retrospective study. SETTING: University teaching hospital. ANIMALS: Five hundred sixty-six dogs and 185 cats that had venous blood gas analysis performed...
November 22, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29165804/intrahepatic-congenital-portosystemic-shunts-in-dogs-short-and-long-term-outcome-of-suture-attenuation
#14
M S Tivers, V J Lipscomb, P Bristow, D J Brockman
OBJECTIVES: To report the short- and long-term outcomes of one- or two-staged suture attenuation for complete closure of intrahepatic congenital portosystemic shunts in dogs. MATERIALS AND METHODS: Retrospective cohort study of dogs surgically treated for intrahepatic congenital portosystemic shunts between February 2000 and March 2015. Long-term follow-up was conducted by telephone conversations with the referring veterinary surgeon, owner, or both. RESULTS: In total, 55 dogs had suture attenuation of their intrahepatic congenital portosystemic shunt; 10 dogs (18·2%) tolerated complete attenuation, whilst 45 dogs (81·8%) tolerated partial attenuation...
November 22, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29165374/connections-between-transcription-downstream-of-genes-and-cis-sage-chimeric-rna
#15
Katarzyna Chwalenia, Fujun Qin, Sandeep Singh, Panjapon Tangtrongstittikul, Hui Li
cis-Splicing between adjacent genes (cis-SAGe) is being recognized as one way to produce chimeric fusion RNAs. However, its detail mechanism is not clear. Recent study revealed induction of transcriptions downstream of genes (DoGs) under osmotic stress. Here, we investigated the influence of osmotic stress on cis-SAGe chimeric RNAs and their connection to DoGs. We found,the absence of induction of at least some cis-SAGe fusions and/or their corresponding DoGs at early time point(s). In fact, these DoGs and their cis-SAGe fusions are inversely correlated...
November 22, 2017: Genes
https://www.readbyqxmd.com/read/29165345/activity-in-vitro-of-clotrimazole-against-canine-methicillin-resistant-and-susceptible-staphylococcus-pseudintermedius
#16
Sian-Marie Frosini, Ross Bond
Emergence of multidrug-resistance in Staphylococcus pseudintermedius (SP) has increased interest in topical therapy as an alternative to systemic antibiotics in canine pyoderma. The antifungal imidazole, clotrimazole, is contained in numerous licensed canine ear preparations. Its in vitro activity against SP has not been evaluated, although previous studies have shown that the related imidazole, miconazole, has significant anti-staphylococcal efficacy. We therefore determined minimum inhibitory concentrations (MICs) of clotrimazole amongst 50 SP isolates (25 methicillin-resistant [MR]SP and susceptible [MS]SP) collected from dogs in Germany during 2010-2011 using an agar dilution method (CLSI VET01-A4)...
November 22, 2017: Antibiotics
https://www.readbyqxmd.com/read/29165024/evaluation-of-separate-role-of-intestine-and-liver-in-first-pass-metabolism-of-budesonide-in-rat
#17
Amol A Raje, Radni D Deshpande, Vishal V Pathade, Vallabh Mahajan, Kaushal Joshi, Ashwini Tambe, Ramana Jinugu, Vamsi L M Madgula, Ashwani Gaur, Vishwottam Kandikere, Chandragouda R Patil, Kasim A Mookhtiar
1. Budesonide, a potent topical corticosteroid, reported to have low oral bioavailability in mice, rat, dog and human due to rapid first pass metabolism. However, there is insufficient information available in literature regarding the role of intestine and or liver responsible for the first pass metabolism of budesonide. 2. Current study in rats investigates the role of intestine and liver in first pass metabolism of budesonide using two in vivo models. Additionally, budesonide was also evaluated in in vitro assays such as thermodynamic solubility, permeability in Caco-2 cells and stability in simulated gastric (SGF), intestinal fluids (SIF) to understand the underlaying cause for low oral bioavailability...
November 22, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29164718/canine-prostate-specific-esterase-cpse-as-an-useful-biomarker-in-preventive-screening-programme-of-canine-prostate-cpse-threshold-value-assessment-and-its-correlation-with-ultrasonographic-prostatic-abnormalities-in-asymptomatic-dogs
#18
S Alonge, M Melandri, R Leoci, G M Lacalandra, G Aiudi
Due to the increased attention that pet-owners devote to their animals and to the improved veterinary care, investigations regarding methods to early detect prostatic disorders that might affect canine life quality have been performed. Canine prostate specific esterase (CPSE) concentration was reported to be higher in dogs suffering from prostatic diseases. This study aimed to estimate the CPSE threshold as a biomarker to early identify prostatic diseases in asymptomatic dogs. The ultrasonographic examination of the prostate was performed in 19 dogs (6-40 kg; 1-5 years) with no symptoms of prostatic diseases...
November 22, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29164321/canine-leishmania-infantum-infection-an-imported-case-in-uk-after-staying-in-the-canary-islands
#19
J R S Dandrieux, F Sacchini, G Harms, M Globokar, H-J Balzer, Nikola Pantchev
Leishmaniosis is reported in the Iberian Peninsula and the Balearic Islands, but the Canary Islands are deemed free. In the present communication, we report a clinical leishmaniosis due to Leishmania infantum in a dog that was presumptively infected during its stay on Tenerife. The result of Leishmania serology (whole-cell based ELISA with L. infantum antigen) was high positive (test score of 82.2 at a cut-off value of 12.0). This result was further confirmed with quantitative real-time polymerase chain reaction (qPCR) for Leishmania spp...
November 21, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29163980/follow-up-monitoring-in-a-cat-with-leishmaniosis-and-coinfections-with-hepatozoon-felis-and-candidatus-mycoplasma-haemominutum
#20
Charalampos Attipa, Kyriaki Neofytou, Christos Yiapanis, Pamela Martínez-Orellana, Gad Baneth, Yaarit Nachum-Biala, Harriet Brooks-Brownlie, Laia Solano-Gallego, Séverine Tasker
Case summary: A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent with amastigotes of Leishmania species. Biochemistry identified a mild hyperproteinaemia. Blood extraction and PCR detected Leishmania species, Hepatozoon species and 'Candidatus Mycoplasma haemominutum' (CMhm) DNA. Subsequent sequencing identified Hepatozoon felis...
July 2017: JFMS open reports
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