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https://www.readbyqxmd.com/read/28800390/how-ag-nanospheres-are-transformed-into-agau-nanocages
#1
Liane M Moreau, Charles A Schurman, Sumit Kewalramani, Mohammad M Shahjamali, Chad A Mirkin, Michael J Bedzyk
Bimetallic hollow, porous noble metal nanoparticles are of broad interest for biomedical, optical and catalytic applications. The most straightforward method for preparing such structures involves the reaction between HAuCl4 and well-formed Ag particles, typically spheres, cubes, or triangular prisms, yet the mechanism underlying their formation is poorly understood at the atomic scale. By combining in situ nanoscopic and atomic-scale characterization techniques (XAFS, SAXS, XRF, and electron microscopy) to follow the process, we elucidate a plausible reaction pathway for the conversion of citrate-capped Ag nanospheres to AgAu nanocages; importantly, the hollowing event cannot be explained by the nanoscale Kirkendall effect, nor by Galvanic exchange alone, two processes that have been previously proposed...
August 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28745125/a-fulminant-case-of-idiopathic-giant-cell-myocarditis
#2
W Schurmans, J Ector, E Verbeken, W Droogne
No abstract text is available yet for this article.
July 26, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28733462/human-t-cell-immunosenescence-and-inflammation-in-aging
#3
REVIEW
Arsun Bektas, Shepherd H Schurman, Ranjan Sen, Luigi Ferrucci
The aging process is driven by a finite number of inter-related mechanisms that ultimately lead to the emergence of characteristic phenotypes, including increased susceptibility to multiple chronic diseases, disability, and death. New assays and analytical tools have become available that start to unravel some of these mechanisms. A prevailing view is that aging leads to an imbalance between stressors and stress-buffering mechanisms that causes loss of compensatory reserve and accumulation of unrepaired damage...
July 21, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28724512/the-health-buddies-app-as-a-novel-tool-to-improve-adherence-and-knowledge-in-atrial-fibrillation-patients-a-pilot-study
#4
Lien Desteghe, Kiki Kluts, Johan Vijgen, Pieter Koopman, Dagmara Dilling-Boer, Joris Schurmans, Paul Dendale, Hein Heidbuchel
BACKGROUND: Atrial fibrillation (AF) constitutes an important risk for stroke, especially in an ageing population. A new app (Health Buddies) was developed as a tool to improve adherence to non-vitamin K antagonist oral anticoagulants (NOACs) in an elderly AF population by providing a virtual contract with their grandchildren, spelling out daily challenges for both. OBJECTIVE: The aim of this pilot study was to assess the feasibility and usability of the Health Buddies app in AF patients...
July 19, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28692655/population-based-incidence-seasonality-and-serotype-distribution-of-invasive-salmonellosis-among-children-in-nanoro-rural-burkina-faso
#5
Issa Guiraud, Annelies Post, Seydou Nakanabo Diallo, Palpouguini Lompo, Jessica Maltha, Kamala Thriemer, Christian Marc Tahita, Benedikt Ley, Karim Derra, Emmanuel Bottieau, Adama Kazienga, Céline Schurmans, Raffaella Ravinetto, Eli Rouamba, Johan Van Griensven, Sophie Bertrand, Halidou Tinto, Jan Jacobs
BACKGROUND: Bloodstream infections (BSI) caused by Salmonella Typhi and invasive non-Typhoidal Salmonella (iNTS) frequently affect children living in rural sub-Saharan Africa but data about incidence and serotype distribution are rare. OBJECTIVE: The present study assessed the population-based incidence of Salmonella BSI and severe malaria in a Health and Demographic Surveillance System in a rural area with seasonal malaria transmission in Nanoro, Burkina Faso. METHODS: Children between 2 months-15 years old with severe febrile illness were enrolled during a one-year surveillance period (May 2013-May 2014)...
2017: PloS One
https://www.readbyqxmd.com/read/28656703/examination-of-competing-diagnostic-models-of-functional-gastrointestinal-disorders-related-to-pain-in-children
#6
J V Schurman, B T Karazsia, C A Friesen
BACKGROUND: There have been no empirical validations of the Rome III or Rome IV criteria in children. The aim of the current study was to examine whether symptoms naturally occur in a pattern consistent with Rome III and/or Rome IV pediatric criteria for functional dyspepsia (FD) and irritable bowel syndrome (IBS). METHODS: We conducted a retrospective cohort study of 250 children, ages 8-17 years, presenting to an abdominal pain clinic with pain of at least 8 weeks duration...
June 28, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28527714/investigation-of-left-and-right-lateral-fluid-percussion-injury-in-c57bl6-j-mice-in-vivo-functional-consequences
#7
Lesley D Schurman, Terry L Smith, Anthony J Morales, Nancy N Lee, Thomas M Reeves, Linda L Phillips, Aron H Lichtman
Although rodent models of traumatic brain injury (TBI) reliably produce cognitive and motor disturbances, behavioral characterization resulting from left and right hemisphere injuries remains unexplored. Here we examined the functional consequences of targeting the left versus right parietal cortex in lateral fluid percussion injury, on Morris water maze (MWM) spatial memory tasks (fixed platform and reversal) and neurological motor deficits (neurological severity score and rotarod). In the MWM fixed platform task, right lateral injury produced a small delay in acquisition rate compared to left...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28469850/zoledronic-acid-for-neonatal-subcutaneous-fat-necrosis
#8
Jeremy A Di Bari, Jennifer A Nead, Scott J Schurman
Subcutaneous fat necrosis (SFN) in infants producing severe hypercalcemia is a life-threatening emergency. Pathophysiology may include enhanced gastrointestinal calcium absorption and bone resorption. We treated an infant with SFN and serum calcium of 15 mg/dL with prednisolone and low-dose zoledronic acid. Serum calcium promptly normalized without rebound hypocalcemia, and redosing of zoledronic acid was not necessary.
May 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28456475/advanced-glycation-end-products-and-strontium-ranelate-promote-osteogenic-differentiation-of-vascular-smooth-muscle-cells-in%C3%A2-vitro-preventive-role-of-vitamin-d
#9
María Silvina Molinuevo, Juan Manuel Fernández, Ana María Cortizo, Antonio Desmond McCarthy, León Schurman, Claudia Sedlinsky
Advanced glycation end products (AGE) have been demonstrated to induce the osteogenic trans-differentiation of vascular smooth muscle cells (VSMC). Strontium ranelate (SR) is an anti-osteoporotic agent that has both anti-catabolic and anabolic actions on bone tissue. However, in the last years SR has been associated with an increase of cardiovascular risk. We hypothesize that SR can increase the osteoblastic trans-differentiation of VSMC and the induction of extracellular calcifications, an effect that could be potentiated in the presence of AGE and inhibited by simultaneous administration of vitamin D...
April 26, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28302370/the-lipid-5-phoshatase-ship2-controls-renal-brush-border-ultrastructure-and-function-by-regulating-the-activation-of-erm-proteins
#10
Sufyan G Sayyed, François Jouret, Marjorie Vermeersch, David Pérez-Morga, Stéphane Schurmans
The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body homeostasis. Here, using the lipid 5-phosphatase Ship2 global knockout mice, proximal tubule-specific Ship2 knockout mice, and a proximal tubule cell model in which SHIP2 is inactivated, we show that SHIP2 is a negative regulator of microvilli formation, thereby controlling solute reabsorption by the proximal tubule...
July 2017: Kidney International
https://www.readbyqxmd.com/read/28261100/endocannabinoids-a-promising-impact-for-traumatic-brain-injury
#11
REVIEW
Lesley D Schurman, Aron H Lichtman
The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous ligands N-arachidonoylethanolamine (anandamide) and 2-arachidonyl glycerol (2-AG). Increases in brain levels of endocannabinoids to pathogenic events suggest this system plays a role in compensatory repair mechanisms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28259010/effects-of-fructose-induced-metabolic-syndrome-on-rat-skeletal-cells-and-tissue-and-their-responses-to-metformin-treatment
#12
Juan Ignacio Felice, León Schurman, Antonio Desmond McCarthy, Claudia Sedlinsky, José Ignacio Aguirre, Ana María Cortizo
AIMS: Deleterious effects of metabolic syndrome (MS) on bone are still controversial. In this study we evaluated the effects of a fructose-induced MS, and/or an oral treatment with metformin on the osteogenic potential of bone marrow mesenchymal stromal cells (MSC), as well as on bone formation and architecture. METHODS: 32 male 8week-old Wistar rats were assigned to four groups: control (C), control plus oral metformin (CM), rats receiving 10% fructose in drinking water (FRD), and FRD plus metformin (FRDM)...
April 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28224099/using-quality-improvement-methods-to-increase-use-of-pain-prevention-strategies-for-childhood-vaccination
#13
Jennifer Verrill Schurman, Amanda D Deacy, Rebecca J Johnson, Jolynn Parker, Kristi Williams, Dustin Wallace, Mark Connelly, Lynn Anson, Kevin Mroczka
AIM: To increase evidence-based pain prevention strategy use during routine vaccinations in a pediatric primary care clinic using quality improvement methodology. METHODS: Specific intervention strategies (i.e., comfort positioning, nonnutritive sucking and sucrose analgesia, distraction) were identified, selected and introduced in three waves, using a Plan-Do-Study-Act framework. System-wide change was measured from baseline to post-intervention by: (1) percent of vaccination visits during which an evidence-based pain prevention strategy was reported as being used; and (2) caregiver satisfaction ratings following the visit...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28147693/inverse-collimated-proton-radiography-for-imaging-thin-materials
#14
Matthew S Freeman, Jason Allison, Malcolm Andrews, Eric Ferm, John J Goett, Kris Kwiatkowski, Julian Lopez, Fesseha Mariam, Mark Marr-Lyon, Michael Martinez, Jason Medina, Patrick Medina, Frank E Merrill, Chris L Morris, Matthew M Murray, Paul Nedrow, Levi P Neukirch, Katherine Prestridge, Paolo Rigg, Alexander Saunders, Tamsen Schurman, Amy Tainter, Frans Trouw, Dale Tupa, Josh Tybo, Wendy Vogan-McNeil, Carl Wilde
Relativistic, magnetically focused proton radiography was invented at Los Alamos National Laboratory using the 800 MeV LANSCE beam and is inherently well-suited to imaging dense objects, at areal densities >20 g cm(-2). However, if the unscattered portion of the transmitted beam is removed at the Fourier plane through inverse-collimation, this system becomes highly sensitive to very thin media, of areal densities <100 mg cm(-2). Here, this inverse-collimation scheme is described in detail and demonstrated by imaging Xe gas with a shockwave generated by an aluminum plate compressing the gas at Mach 8...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28140312/-argentine-guidelines-for-the-diagnosis-prevention-and-treatment-of-osteoporosis-2015
#15
León Schurman, Ana M Galich, Claudio González, Diana González, Osvaldo D Messina, Claudia Sedlinsky, Claudia R Uñas, Ariel Sánchez
Osteoporosis is an evolving disease which affects over 200 million people worldwide. Our recommendations are guidelines for its diagnosis, prevention and treatment, but they do not constitute standards for clinical decisions in individual cases. The physician must adapt them to individual special situations, incorporating personal factors that transcend the limits of these guidelines and are dependent on the knowledge and art of the practice of Medicine. These guidelines should be reviewed and updated periodically as new, better and more effective diagnostic and therapeutic tools become available...
2017: Medicina
https://www.readbyqxmd.com/read/28135199/pre-exposure-prophylaxis-prep-as-an-additional-tool-for-hiv-prevention-among-men-who-have-sex-with-men-in-belgium-the-be-prep-ared-study-protocol
#16
Irith De Baetselier, Thijs Reyniers, Christiana Nöstlinger, Kristien Wouters, Katrien Fransen, Tania Crucitti, Chris Kenyon, Jozefien Buyze, Céline Schurmans, Marie Laga, Bea Vuylsteke
BACKGROUND: Pre-exposure prophylaxis (PrEP) is a promising and effective tool to prevent HIV. With the approval of Truvada as daily PrEP by the European Commission in August 2016, individual European Member states prepare themselves for PrEP implementation following the examples of France and Norway. However, context-specific data to guide optimal implementation is currently lacking. OBJECTIVE: With this demonstration project we evaluate whether daily and event-driven PrEP, provided within a comprehensive prevention package, is a feasible and acceptable additional prevention tool for men who have sex with men (MSM) at high risk of acquiring HIV in Belgium...
January 30, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/27895848/four-artemisinin-based-treatments-in-african-pregnant-women-with-malaria
#17
RANDOMIZED CONTROLLED TRIAL
Divine Pekyi, Akua A Ampromfi, Halidou Tinto, Maminata Traoré-Coulibaly, Marc C Tahita, Innocent Valéa, Victor Mwapasa, Linda Kalilani-Phiri, Gertrude Kalanda, Mwayiwawo Madanitsa, Raffaella Ravinetto, Theonest Mutabingwa, Prosper Gbekor, Harry Tagbor, Gifty Antwi, Joris Menten, Maaike De Crop, Yves Claeys, Celine Schurmans, Chantal Van Overmeir, Kamala Thriemer, Jean-Pierre Van Geertruyden, Umberto D'Alessandro, Michael Nambozi, Modest Mulenga, Sebastian Hachizovu, Jean-Bertin B Kabuya, Joyce Mulenga
BACKGROUND: Information regarding the safety and efficacy of artemisinin combination treatments for malaria in pregnant women is limited, particularly among women who live in sub-Saharan Africa. METHODS: We conducted a multicenter, randomized, open-label trial of treatments for malaria in pregnant women in four African countries. A total of 3428 pregnant women in the second or third trimester who had falciparum malaria (at any parasite density and regardless of symptoms) were treated with artemether-lumefantrine, amodiaquine-artesunate, mefloquine-artesunate, or dihydroartemisinin-piperaquine...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27812101/experiences-and-lessons-from-a-multicountry-nidiag-study-on-persistent-digestive-disorders-in-the-tropics
#18
Sören L Becker, Peiling Yap, Ninon S Horié, Emilie Alirol, Barbara Barbé, Nisha K Bhatta, Narayan R Bhattarai, Emmanuel Bottieau, Justin K Chatigre, Jean T Coulibaly, Hassan K M Fofana, Jan Jacobs, Prahlad Karki, Basudha Khanal, Stefanie Knopp, Kanika Koirala, Yodi Mahendradhata, Pascal Mertens, Fransiska Meyanti, Elsa H Murhandarwati, Eliézer K N'Goran, Rosanna W Peeling, Bickram Pradhan, Raffaella Ravinetto, Suman Rijal, Moussa Sacko, Rénion Saye, Pierre H H Schneeberger, Céline Schurmans, Kigbafori D Silué, Peter Steinmann, Harry van Loen, Kristien Verdonck, Lisette van Lieshout, Lutz von Müller, Joel A Yao, Marleen Boelaert, François Chappuis, Katja Polman, Jürg Utzinger
No abstract text is available yet for this article.
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27788131/the-impact-of-environmental-and-endogenous-damage-on-somatic-mutation-load-in-human-skin-fibroblasts
#19
Natalie Saini, Steven A Roberts, Leszek J Klimczak, Kin Chan, Sara A Grimm, Shuangshuang Dai, David C Fargo, Jayne C Boyer, William K Kaufmann, Jack A Taylor, Eunjung Lee, Isidro Cortes-Ciriano, Peter J Park, Shepherd H Schurman, Ewa P Malc, Piotr A Mieczkowski, Dmitry A Gordenin
Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and improving the prognosis and prevention of cancers and other genetic diseases. Previous methods relying on either the generation of induced pluripotent stem cells, or sequencing of single-cell genomes were inherently error-prone and did not allow independent validation of the mutations...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27694492/inositol-triphosphate-3-kinase-c-mediates-inflammasome-activation-and-treatment-response-in-kawasaki-disease
#20
Martin Prince Alphonse, Trang T Duong, Chisato Shumitzu, Truong Long Hoang, Brian W McCrindle, Alessandra Franco, Stéphane Schurmans, Dana J Philpott, Martin L Hibberd, Jane Burns, Taco W Kuijpers, Rae S M Yeung
Kawasaki disease (KD) is a multisystem vasculitis that predominantly targets the coronary arteries in children. Phenotypic similarities between KD and recurrent fever syndromes point to the potential role of inflammasome activation in KD. Mutations in NLRP3 are associated with recurrent fever/autoinflammatory syndromes. We show that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1β and IL-18...
November 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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