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Martin Prince Alphonse, Trang T Duong, Chisato Shumitzu, Truong Long Hoang, Brian W McCrindle, Alessandra Franco, Stéphane Schurmans, Dana J Philpott, Martin L Hibberd, Jane Burns, Taco W Kuijpers, Rae S M Yeung
Kawasaki disease (KD) is a multisystem vasculitis that predominantly targets the coronary arteries in children. Phenotypic similarities between KD and recurrent fever syndromes point to the potential role of inflammasome activation in KD. Mutations in NLRP3 are associated with recurrent fever/autoinflammatory syndromes. We show that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1β and IL-18...
September 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Lien Desteghe, Lara Engelhard, Zina Raymaekers, Kiki Kluts, Johan Vijgen, Dagmara Dilling-Boer, Pieter Koopman, Joris Schurmans, Paul Dendale, Hein Heidbuchel
OBJECTIVE: The aim of this study was to develop and validate a new questionnaire, the Jessa Atrial fibrillation Knowledge Questionnaire (JAKQ), to test the knowledge of patients with atrial fibrillation (AF) about the arrhythmia, its treatment and their ability for self-management. METHODS: The JAKQ was developed based on other questionnaires, two educational checklists and patient information support websites. The JAKQ was validated based on content validity, face validity, response process, discriminatory potential and sensitivity of the questionnaire, construct validity and reliability...
November 15, 2016: International Journal of Cardiology
Craig A Friesen, John M Rosen, Jennifer V Schurman
BACKGROUND: The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms. METHODS: The study was a retrospective review of 100 consecutive pediatric patients, age 8-17 years, diagnosed with FD...
2016: BMC Gastroenterology
Bonney Reed-Knight, Robyn Lewis Claar, Jennifer Verrill Schurman, Miranda A L van Tilburg
INTRODUCTION: Functional GI disorders (FGIDs) are common in adults and children. Psychological factors play an important role in the onset and maintenance of FGIDs and in explaining the associated disability. Psychological treatments such as Cognitive Behavioral Therapy and Hypnotherapy have been found efficacious in FGIDs but Integrating psychological treatments into traditionally medically-oriented care can be challenging. AREAS COVERED: This review outlines the case for integrating psychological therapies into medical care for FGIDs and examine various models of integrated care that can be adapted to fit specific practice scenarios...
September 2016: Expert Review of Gastroenterology & Hepatology
Ariane Scoumanne, Patricia Molina-Ortiz, Daniel Monteyne, David Perez-Morga, Christophe Erneux, Stéphane Schurmans
Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases family which phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate. Although expression and function of the two other family members ITPKA and ITPKB are rather well characterized, similar information is lacking for ITPKC. Here, we first defined the expression of Itpkc mRNA and protein in mouse tissues and cells using in situ hybridization and new antibodies...
March 22, 2016: Advances in Biological Regulation
Lien Desteghe, Zina Raymaekers, Mark Lutin, Johan Vijgen, Dagmara Dilling-Boer, Pieter Koopman, Joris Schurmans, Philippe Vanduynhoven, Paul Dendale, Hein Heidbuchel
AIMS: To determine the usability, accuracy, and cost-effectiveness of two handheld single-lead electrocardiogram (ECG) devices for atrial fibrillation (AF) screening in a hospital population with an increased risk for AF. METHODS AND RESULTS: Hospitalized patients (n = 445) at cardiological or geriatric wards were screened for AF by two handheld ECG devices (MyDiagnostick and AliveCor). The performance of the automated algorithm of each device was evaluated against a full 12-lead or 6-lead ECG recording...
February 17, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Katherine Zybach, Craig A Friesen, Jennifer V Schurman
AIM: To study the effectiveness of melatonin vs placebo in children with functional dyspepsia (FD). METHODS: The study was conducted as a double blind, randomized, placebo controlled crossover trial. Subjects were aged 8-17 years and diagnosed with FD based on Rome III criteria. All subjects had failed to respond to 4 wk of acid suppression. Subjects receive a continuous two weeks of placebo and a continuous two weeks of melatonin in an order blinded to the participant and the study team...
February 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
Dieter Dauwe, Nick Hiltrop, Willem Schurmans, Philippe Moerman, Jan Bogaert, Stefan Janssens, Mark Coosemans
No abstract text is available yet for this article.
February 8, 2016: JACC. Cardiovascular Interventions
Mark Connelly, Dustin P Wallace, Kristi Williams, JoLynn Parker, Jennifer V Schurman
OBJECTIVES: Evidence-based pain-limiting strategies for pediatric immunizations remain underutilized, with barriers identified to date mostly pertaining to health care providers and systems of care. The present study sought to quantify and investigate parent attitudes toward pain management as another potential barrier to the routine use of pain-mitigating strategies during immunizations. MATERIALS AND METHODS: Questionnaires measuring parent attitudes, willingness to pay, and perceived barriers for using pain management for immunizations were completed by 259 parent/guardians of children ages 0 to 5 years attending appointments at an urban primary care clinic in the Midwestern United States...
August 2016: Clinical Journal of Pain
Andrea A Wojtowicz, Jill M Plevinsky, Natasha Poulopoulos, Jennifer V Schurman, Rachel N Greenley
BACKGROUND AND AIMS: Traditional definitions of healthcare utilization (HCU) emphasize clinical visits and procedures. Clinic calls, an understudied form of HCU, occur with high frequency. Understanding and examining predictors of HCU, such as disease activity and parent distress, may help reduce overutilization. METHODS: A total of 68 adolescents with inflammatory bowel disease [IBD; mean (SD) =14.18 (1.92) years] and their parents participated. Parent distress was assessed through parent report on the PedsQL Family Impact Module, and physicians provided ratings of patient disease activity using the Physician's Global Assessment index...
April 2016: European Journal of Gastroenterology & Hepatology
Craig A Friesen, Jennifer V Schurman, Susan M Abdel-Rahman
At the present time, it is nearly impossible to treat pediatric functional gastrointestinal disorders associated with pain in an evidence based fashion. This is due to the overall lack of controlled studies and, even more importantly, the complexity of the contributors to disease phenotype which are not controlled or accounted for in most therapeutic trials. In this manuscript, we review the challenges of defining entry criteria, controlling for the large number of biopsychosocial factors which may effect outcomes, and understanding pharmacokinetic and pharmacodynamic factors when designing therapeutic trials for abdominal pain in children...
November 6, 2015: World Journal of Gastrointestinal Pharmacology and Therapeutics
Katja Polman, Sören L Becker, Emilie Alirol, Nisha K Bhatta, Narayan R Bhattarai, Emmanuel Bottieau, Martin W Bratschi, Sakib Burza, Jean T Coulibaly, Mama N Doumbia, Ninon S Horié, Jan Jacobs, Basudha Khanal, Aly Landouré, Yodi Mahendradhata, Filip Meheus, Pascal Mertens, Fransiska Meyanti, Elsa H Murhandarwati, Eliézer K N'Goran, Rosanna W Peeling, Raffaella Ravinetto, Suman Rijal, Moussa Sacko, Rénion Saye, Pierre H H Schneeberger, Céline Schurmans, Kigbafori D Silué, Jarir A Thobari, Mamadou S Traoré, Lisette van Lieshout, Harry van Loen, Kristien Verdonck, Lutz von Müller, Cédric P Yansouni, Joel A Yao, Patrick K Yao, Peiling Yap, Marleen Boelaert, François Chappuis, Jürg Utzinger
No abstract text is available yet for this article.
2015: BMC Infectious Diseases
Gholamali Jafari, Brian M Wasko, Ashley Tonge, Nathan Schurman, Cindy Dong, Zhongyu Li, Rebecca Peters, Ernst-Bernhard Kayser, Jason N Pitt, Phil G Morgan, Margaret M Sedensky, Antony R Crofts, Matt Kaeberlein
Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend the lifespan of model organisms. The Caenorhabditis elegans isp-1 gene encodes the Rieske iron-sulfur protein subunit of cytochrome c oxidoreductase (complex III of the electron transport chain). The partial loss of function allele, isp-1(qm150), leads to several pleiotropic phenotypes. To better understand the molecular mechanisms of ISP-1 function, we sought to identify genetic suppressors of the delayed development of isp-1(qm150) animals...
November 10, 2015: Proceedings of the National Academy of Sciences of the United States of America
Kristina A Thayer, Kyla W Taylor, Stavros Garantziotis, Shepherd H Schurman, Grace E Kissling, Dawn Hunt, Brenda Herbert, Rebecca Church, Rachael Jankowich, Mona I Churchwell, Richard C Scheri, Linda S Birnbaum, John R Bucher
BACKGROUND: Bisphenol A (BPA) is a high-production-volume chemical associated with a wide range of health outcomes in animal and human studies. BPA is used as a developer in thermal paper products, including cash register receipt paper; however, little is known about exposure of cashiers to BPA and alternative compounds in receipt paper. OBJECTIVE: We determined whether handling receipt paper results in measurable absorption of BPA or the BPA alternatives bisphenol S (BPS) and 4-hydroxyphenyl 4-isoprooxyphenylsulfone (BPSIP)...
April 2016: Environmental Health Perspectives
Francesc R Garcia-Gonzalo, Siew Cheng Phua, Elle C Roberson, Galo Garcia, Monika Abedin, Stéphane Schurmans, Takanari Inoue, Jeremy F Reiter
Primary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for signaling is unclear. One possibility is that some forms of signaling require a distinct membrane lipid composition, found at cilia. We found that the ciliary membrane contains a particular phosphoinositide, PI(4)P, whereas a different phosphoinositide, PI(4,5)P2, is restricted to the membrane of the ciliary base. This distribution is created by Inpp5e, a ciliary phosphoinositide 5-phosphatase. Without Inpp5e, ciliary PI(4,5)P2 levels are elevated and Hh signaling is disrupted...
August 24, 2015: Developmental Cell
Katja Polman, Sören L Becker, Emilie Alirol, Nisha K Bhatta, Narayan R Bhattarai, Emmanuel Bottieau, Martin W Bratschi, Sakib Burza, Jean T Coulibaly, Mama N Doumbia, Ninon S Horié, Jan Jacobs, Basudha Khanal, Aly Landouré, Yodi Mahendradhata, Filip Meheus, Pascal Mertens, Fransiska Meyanti, Elsa H Murhandarwati, Eliézer K N'Goran, Rosanna W Peeling, Raffaella Ravinetto, Suman Rijal, Moussa Sacko, Rénion Saye, Pierre H H Schneeberger, Céline Schurmans, Kigbafori D Silué, Jarir A Thobari, Mamadou S Traoré, Lisette van Lieshout, Harry van Loen, Kristien Verdonck, Lutz von Müller, Cédric P Yansouni, Joel A Yao, Patrick K Yao, Peiling Yap, Marleen Boelaert, François Chappuis, Jürg Utzinger
BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14 days), the spectrum of pathogens that may give rise to persistent diarrhoea (≥14 days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue...
2015: BMC Infectious Diseases
P Del Corral, R C Schurman, S S Kinza, M J Fitzgerald, C A Kordick, J L Rusch, J B Nadolski
INTRODUCTION: The cortisol, cortisone, corticosterone, and CBG responses to exercise in the AM and PM have not been described. This study examined the response of these glucocorticoids and CBG to intense exercise in 12 endurance-trained men in plasma (Pl) and saliva (Sa). METHODS: Each subject completed treadmill exercise in the morning and evening. Paired blood and Sa samples were obtained at rest before and after exercise. RESULTS: Significant time effect existed for Pl-cortisol and Sa-cortisol from baseline in the AM and PM (p < 0...
March 2016: Journal of Endocrinological Investigation
Marcelo Chávez, Sabrina Ena, Jacqueline Van Sande, Alban de Kerchove d'Exaerde, Stéphane Schurmans, Serge N Schiffmann
Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown. Here we report that in neural stem cells, phosphatidylinositol 4-phosphate (PI4P) is found in high levels in cilia whereas phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is not detectable. Upon INPP5E inactivation, PI(4,5)P2 accumulates at the ciliary tip whereas PI4P is depleted...
August 10, 2015: Developmental Cell
Kristina A Thayer, Daniel R Doerge, Dawn Hunt, Shepherd H Schurman, Nathan C Twaddle, Mona I Churchwell, Stavros Garantziotis, Grace E Kissling, Michael R Easterling, John R Bucher, Linda S Birnbaum
BACKGROUND: Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA. OBJECTIVE: To reduce uncertainties about the metabolism and excretion of BPA in humans following oral administration. METHODS: We exposed six men and eight women to 100 μg/kg bw of deuterated BPA (d6-BPA) by oral administration and conducted blood and urine analysis over a three day period. The use of d6-BPA allowed administered d6-BPA to be distinguished from background native (unlabeled) BPA...
October 2015: Environment International
N M Hijaz, C A Friesen, J V Schurman, R E Pearce, S M Abdel-Rahman
BACKGROUND: Adult studies indicate a role for ghrelin in functional dyspepsia (FD) mediated through ghrelin's effect on gastric emptying (GE). This study examines the relationship between ghrelin, liquid GE, and pain in children with FD. METHODS: Thirteen FD patients reporting symptoms consistent with post-prandial distress syndrome (PDS) and 17 healthy controls were enrolled. All participants received a liquid meal containing (13) C-sodium acetate. Pain severity, liquid GE utilizing exhaled (13) CO2 from the sodium acetate breath tests (ABT), plasma acyl ghrelin (AG), and des-acyl ghrelin concentrations were measured at specific intervals over 240 min following ingestion...
August 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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