keyword
MENU ▼
Read by QxMD icon Read
search

Bloodstream infection detection

keyword
https://www.readbyqxmd.com/read/29661874/characterization-of-extensively-or-pandrug-resistant-st147-and-st101-oxa-48-producing-klebsiella-pneumoniae-isolates-causing-bloodstream-infections-in-icu-patients
#1
Kalliope Avgoulea, Vincenzo Di Pilato, Olympia Zarkotou, Samanta Sennati, Leda Politi, Antonio Cannatelli, Katerina Themeli-Digalaki, Tommaso Giani, Athanassios Tsakris, Gian Maria Rossolini, Spyros Pournaras
Carbapenem-resistant Klebsiella pneumoniae cause important healthcare-associated infections worldwide. An outbreak of ST11 OXA-48-producing K. pneumoniae isolates (OXA-48-Kp) occurred in Tzaneio Hospital in 2012 and was contained until 2014, when OXA-48-Kp reemerged. The present study involved 19 bloodstream infection (BSI) OXA-48-Kp recovered from 19 ICU patients hospitalized between August 2014 and July 2016. MICs were determined by broth microdilution. β-lactamase genes were detected by PCR. All isolates were typed by PFGE/MLST and 10 representative isolates by next generation sequencing (NGS)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29652746/fluorine-18-fluorodeoxyglucose-pet-ct-in-hematopoietic-stem-cell-transplant-patients-with-fusariosis-initial-findings-of-a-case-series-review
#2
Marcelo R Schirmer, Michel P Carneiro, Luiz S Machado, Alessandra L da S Chaves, Flávia P P L Lopes
BACKGROUND: Fusariosis is an opportunistic fungal infection that affects mostly leukemic and hematopoietic stem cell transplant patients. Locally invasive and disseminated infection may occur. Treatment is challenging, and besides evaluation of immune status, one also needs to take into account organ involvement to predict the duration and prognosis. OBJECTIVE: The aim of this study was to present the findings and clinical follow-up from a series of cases of Fusarium spp...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29650891/-fourteen-cases-of-implanted-central-venous-access-port-related-bloodstream-infection
#3
Toshihiko Sakai, Masakazu Kono, Chie Koumura, Yuri Oyano, Noriko Sakuma, Hirokazu Tojima
We conducted a clinical study involving cases of central venous(CV)port-related infection in Tokyo Rosai Hospital. Fourteen patients with suspected CV port-related infection at Tokyo Rosai Hospital between April 2015 and January 2017 were observed. Identical bacterial types were detected from 2 sets of blood cultures and cultures from the catheter tip, and a definitive diagnosis was made. Data on patient background, causative bacteria, quick sequentialorgan failure assessment (qSOFA)score, CV port placement period, presence or absence of local inflammatory findings, and prognosis were analysed...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#4
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29642828/-comparison-of-clinical-laboratory-standards-institute-clsi-and-european-committee-on-antimicrobial-susceptibility-testing-eucast-broth-microdilution-methods-for-determining-the-susceptibilities-of-candida-isolates
#5
Burcu Dalyan Cilo, Tuncay Topaç, Harun Ağca, Sezcan Sağlam, Kadir Efe, Beyza Ener
Candida species are among the top 10 pathogens causing bloodstream infections associated with high morbidity, mortality. In spite of the development of new antifungal drugs, epidemiological studies have shown that resistance to antifungal drugs among Candida isolates is becoming a serious problem. The aim of this study was to compare the antifungal broth microdilution methods of the Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) for amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole and anidulafungin susceptibility of Candida blood isolates...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29619012/experimental-inoculation-in-rats-and-mice-by-the-giant-marseillevirus-leads-to-long-term-detection-of-virus
#6
Sarah Aherfi, Claude Nappez, Hubert Lepidi, Marielle Bedotto, Lina Barassi, Priscilla Jardot, Philippe Colson, Bernard La Scola, Didier Raoult, Fabienne Bregeon
The presence of the giant virus of amoeba Marseillevirus has been identified at many different sites on the human body, including in the bloodstream of asymptomatic subjects, in the lymph nodes of a child with adenitis, in one adult with Hodgkin's disease, and in the pharynx of an adult. A high seroprevalence of the Marseillevirus has been recorded in the general population. Whether Marseillevirus can disseminate and persist within a mammal after entry remains unproven. We aimed to assess the ability of the virus to disseminate and persist into healthy organisms, especially in the lymphoid organs...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29618394/comparison-of-predictors-and-mortality-between-bloodstream-infections-caused-by-esbl-producing-escherichia-coli-and-esbl-producing-klebsiella-pneumoniae
#7
Oded Scheuerman, Vered Schechner, Yehuda Carmeli, Belen Gutiérrez-Gutiérrez, Esther Calbo, Benito Almirante, Pier-Luigy Viale, Antonio Oliver, Patricia Ruiz-Garbajosa, Oriol Gasch, Monica Gozalo, Johann Pitout, Murat Akova, Carmen Peña, Jose Molina, Alicia Hernández-Torres, Mario Venditti, Nuria Prim, Julia Origüen, German Bou, Evelina Tacconelli, Maria Tumbarello, Axel Hamprecht, Ilias Karaiskos, Cristina de la Calle, Federico Pérez, Mitchell J Schwaber, Joaquin Bermejo, Warren Lowman, Po-Ren Hsueh, Carolina Navarro-San Francisco, Robert A Bonomo, David L Paterson, Alvaro Pascual, Jesus Rodríguez-Baño
OBJECTIVETo compare the epidemiology, clinical characteristics, and mortality of patients with bloodstream infections (BSI) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) versus ESBL-producing Klebsiella pneumoniae (ESBL-KP) and to examine the differences in clinical characteristics and outcome between BSIs caused by isolates with CTX-M versus other ESBL genotypesMETHODSAs part of the INCREMENT project, 33 tertiary hospitals in 12 countries retrospectively collected data on adult patients diagnosed with ESBL-EC BSI or ESBL-KP BSI between 2004 and 2013...
April 5, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29608754/t2-magnetic-resonance-for-the-diagnosis-of-bloodstream-infections-charting-a-path-forward
#8
Cornelius J Clancy, M Hong Nguyen
We discuss four studies in this issue of the Journal of Antimicrobial Chemotherapy that describe experience with T2 magnetic resonance (T2MR) nanodiagnostics for Candida and bacterial bloodstream infections, in the context of the T2MR literature. T2Candida and T2Bacteria panels use a dedicated instrument to detect amplified DNA from microbial cells directly in whole blood. T2Candida gives positive or negative results for C. albicans/C. tropicalis, C. glabrata/C. krusei, and C. parapsilosis. T2Bacteria detects Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli...
March 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29608753/t2bacteria-magnetic-resonance-assay-for-the-rapid-detection-of-eskapec-pathogens-directly-in-whole-blood
#9
Giulia De Angelis, Brunella Posteraro, Elena De Carolis, Giulia Menchinelli, Francesco Franceschi, Mario Tumbarello, Gennaro De Pascale, Teresa Spanu, Maurizio Sanguinetti
Objectives: To evaluate the magnetic resonance-based T2Bacteria Panel assay for direct detection of ESKAPEc (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli) pathogens in blood samples of patients with suspected bloodstream infection (BSI). Patients and methods: Adult patients admitted to the Emergency Medicine Department, Infectious Diseases Unit and ICU of a large tertiary-care hospital were included if they had a blood culture (BC) ordered concomitantly with a whole-blood sample for T2Bacteria testing...
March 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29608117/clinical-impact-of-rapid-bacterial-identification-by-maldi-tof-ms-combined-with-the-b%C3%A3%C2%AAta-lacta%C3%A2-test-on-early-antibiotic-adaptation-by-an-antimicrobial-stewardship-team-in-bloodstream-infections
#10
A Mizrahi, J Amzalag, C Couzigou, G Péan De Ponfilly, B Pilmis, A Le Monnier
BACKGROUND: Bloodstream infections (BSI) can potentially be life-threatening infections and are associated with a high crude mortality, moreover with an inappropriate first-line antibiotic therapy. Bacterial resistance is more and more frequently observed. New strategies of BSI management are urgently needed. MATERIALS AND METHODS: During an 18-months period, we prospectively evaluated the clinical impact of rapid bacterial identification by MALDI-TOF MS technology combined with an antimicrobial stewardship team (AST) intervention...
April 2, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29605563/rapid-phenotypic-methods-to-improve-the-diagnosis-of-bacterial-bloodstream-infections-meeting-the-challenge-to-reduce-the-time-to-result
#11
REVIEW
Grégory Dubourg, Brigitte Lamy, Raymond Ruimy
BACKGROUND: Administration of appropriate antimicrobial therapy is one of the key factors in surviving bloodstream infections. Blood culture (BC) is currently the gold standard for diagnosis, but conventional practices have long turnaround times while diagnosis need to be faster to improve patient care. Phenotypic methods offer an advantage over genotypic methods in that they can identify a wide range of taxa, detect the resistance currently expressed, and resist genetic variability in resistance detection...
March 29, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29588851/vancomycin-resistant-enterococcus-faecium-sequence-type-796-rapid-international-dissemination-of-a-new-epidemic-clone
#12
Andrew A Mahony, Andrew H Buultjens, Susan A Ballard, Elizabeth A Grabsch, Shirley Xie, Torsten Seemann, Rhonda L Stuart, Despina Kotsanas, Allen Cheng, Helen Heffernan, Sally A Roberts, Geoffrey W Coombs, Narin Bak, John K Ferguson, Glen C Carter, Benjamin P Howden, Timothy P Stinear, Paul D R Johnson
Background: Vancomycin-resistant Enterococcus faecium (VRE) is a leading cause of hospital-acquired infections. New, presumably better-adapted strains of VRE appear unpredictably; it is uncertain how they spread despite improved infection control. We aimed to investigate the relatedness of a novel sequence type (ST) of vanB E. faecium - ST796 - very near its time of origin from hospitals in three Australian states and New Zealand. Methods: Following near-simultaneous outbreaks of ST796 in multiple institutions, we gathered then tested colonization and bloodstream infection isolates' antimicrobial resistance (AMR) phenotypes, and phylogenomic relationships using whole genome sequencing (WGS)...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29566151/in-vivo-evolution-of-resistant-subpopulations-of-kpc-producing-klebsiella-pneumoniae-during-ceftazidime-avibactam-treatment
#13
Paolo Gaibani, Caterina Campoli, Russell E Lewis, Silvia Lidia Volpe, Erika Scaltriti, Maddalena Giannella, Stefano Pongolini, Andrea Berlingeri, Francesco Cristini, Michele Bartoletti, Sara Tedeschi, Simone Ambretti
Objectives: KPC-producing Klebsiella pneumoniae (KPC-Kp) represent a serious problem worldwide. Herein, we describe the evolution of ceftazidime/avibactam resistance by sequencing longitudinal clinical isolates from a patient with KPC-Kp bloodstream infection undergoing ceftazidime/avibactam treatment. Methods: WGS was performed on one ceftazidime/avibactam-susceptible KPC-Kp (BOT-CA-S) and two phenotypically different ceftazidime/avibactam-resistant KPC-Kp with low (BOT-CA-R) and high (BOT-EMO) carbapenem MICs...
March 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29563910/molecular-epidemiology-of-staphylococcus-epidermidis-implicated-in-catheter-related-bloodstream-infections-at-an-academic-hospital-in-pretoria-south-africa
#14
Marthie M Ehlers, Wilhelmina Strasheim, Michelle Lowe, Veronica Ueckermann, Marleen M Kock
Staphylococcus epidermidis is one of the most prevalent pathogens implicated in catheter-related bloodstream infections (CRBSI) at an academic hospital in Pretoria, South Africa. Little is known about the clonality and the prevalence of antibiotic resistance and virulence genes in S. epidermidis (e.g., ica AB, IS 256, mec A, and qac A/B). A total of 508 intravascular catheters (IVCs) from 331 patients were submitted for culture from May to October 2013. Only 50% ( n = 253/508) of the IVCs were accompanied by blood cultures (BCs) taken within 48 h...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29540455/improvement-of-bartonella-henselae-dna-detection-in-cat-blood-samples-by-combining-molecular-and-culture-methods
#15
Marina Rovani Drummond, Bruno Grosselli Lania, Pedro Paulo Vissoto de Paiva Diniz, Rovilson Gilioli, Daniele Masselli Rodrigues Demolin, Diana Gerardi Scorpio, Edward B Breitschwerdt, Paulo Eduardo Neves Ferreira Velho
Bartonella spp. constitute bacteria of worldwide distribution that cause asymptomatic to fatal infections in animals and humans. The most common zoonotic species is Bartonella henselae , for which cats are the major natural reservoir host. To better understand Bartonella sp. diagnostic limitations, we determined the frequency of bloodstream infection in 112 cats by comparing and combining the results of multiple conventional and nested PCRs from blood and liquid culture samples. Using liquid culture conventional PCR, Bartonella sp...
March 14, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29518166/diagnostic-accuracy-of-antigen-based-immunochromatographic-rapid-diagnostic-tests-for-the-detection-of-salmonella-in-blood-culture-broth
#16
Laura M F Kuijpers, Panha Chung, Marjan Peeters, Marie-France Phoba, Chun Kham, Barbara Barbé, Octavie Lunguya, Jan Jacobs
BACKGROUND: In low resource settings, Salmonella serovars frequently cause bloodstream infections. This study investigated the diagnostic performance of immunochromatographic rapid diagnostic tests (RDTs), which detect Salmonella antigens, when applied to stored grown blood culture broth. MATERIAL/METHODS: The SD Bioline One Step Salmonella Typhi Ag Rapid Detection Kit (Standard Diagnostics, Republic of Korea), marketed for the detection of Salmonella enterica serovar Typhi (Salmonella Typhi) in stool and the Salmonella Ag Rapid Test (Creative Diagnostics, USA), marketed for the detection of all Salmonella serotypes in stool, were selected for evaluation based on a pre-test evaluation of six RDT products...
2018: PloS One
https://www.readbyqxmd.com/read/29491477/comprehensive-detection-of-pathogens-in-immunocompromised-children-with-bloodstream-infections-by-next-generation-sequencing
#17
Kazuhiro Horiba, Jun-Ichi Kawada, Yusuke Okuno, Nobuyuki Tetsuka, Takako Suzuki, Shotaro Ando, Yasuko Kamiya, Yuka Torii, Tetsuya Yagi, Yoshiyuki Takahashi, Yoshinori Ito
Bloodstream infection (BSI) is a severe complication in immunocompromised patients. Next-generation sequencing (NGS) allows us to analyze comprehensively and quantitatively all microorganisms present in a clinical sample. Thirty-five pediatric patients (12 with BSI and 23 with suspected BSI/negative blood culture) were enrolled. Plasma/serum samples were used for sequencing and the results were compared with those from blood culture. Sequencing reads of bacteria isolated in blood culture were identified by NGS in all plasma/serum samples at disease onset...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29481659/cytokine-release-syndrome-grade-is-a-predictive-marker-for-infections-in-relapsed-or-refractory-b-cell-all-patients-treated-with-car-t-cells
#18
Jae H Park, F Andres Romero, Ying Taur, Michel Sadelain, Renier J Brentjens, Tobias M Hohl, Susan K Seo
Background: Chimeric antigen receptor (CAR)-modified T cells that target the CD19 antigen present a novel promising therapy for the treatment of relapsed B-cell acute lymphoblastic leukemia (ALL). Although cytokine release syndrome (CRS) and neurotoxicity have emerged as predominant non-infectious complications of CD19 CAR T cell therapy, infections associated with this treatment modality have not been well documented. Methods: We analyzed infectious complications that followed CD19 CAR T cell therapy in 53 adult patients with relapsed ALL enrolled in a phase I clinical trial at Memorial Sloan Kettering Cancer Center (NCT01044069)...
February 22, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29467368/culture-free-bacterial-detection-and-identification-from-blood-with-rapid-phenotypic-antibiotic-susceptibility-testing
#19
Xuyang Shi, Usha Kadiyala, J Scott VanEpps, Siu-Tung Yau
The current culture-based approach for the diagnosis of bloodstreams infection is incommensurate with timely treatment and curbing the prevalence of multi-drug resistant organisms (MDROs) due to its long time-to-result. Bloodstream infections typically involve extremely low (e.g., <10 colony-forming unit (CFU)/mL) bacterial concentrations that require a labor-intensive process and as much as 72 hours to yield a diagnosis. Here, we demonstrate a culture-free approach to achieve rapid diagnosis of bloodstream infections...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29460534/focus-on-periodontal-disease-and-development-of-endocarditis
#20
F Carinci, M Martinelli, M Contaldo, R Santoro, F Pezzetti, D Lauritano, V Candotto, D Mucchi, A Palmieri, A Tagliabue, L Tettamanti
Infective endocarditis is a devastating disease with high morbidity and mortality. The link to oral bacteria has been known for many decades and has caused ongoing concern for dentists, patients and cardiologists. The microbiota of the mouth is extremely diverse and more than 700 bacterial species have been detected. Half of them are uncultivable so far. Oral microbiota is not uniform, specific sites exist in the mouth such as tongue, palate, cheek, teeth and periodontal pockets that have their own microbiota...
January 2018: Journal of Biological Regulators and Homeostatic Agents
keyword
keyword
69974
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"