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https://www.readbyqxmd.com/read/29161789/current-status-of-thyroid-fine-needle-aspiration-practice-in-thailand
#1
REVIEW
Somboon Keelawat, Samreung Rangdaeng, Supinda Koonmee, Tikamporn Jitpasutham, Andrey Bychkov
Thyroid carcinoma is one of the leading malignancies in Thailand increasingly prevalent in the female population. Fine-needle aspiration (FNA) cytology is a widely used diagnostic tool for evaluation of thyroid nodules and thyroid cancer. Thyroid FNA is a routine procedure universally performed in Thai hospitals by a variety of clinical specialists. Manual guidance is the first-line choice complemented by ultrasound assistance in selected cases. Despite national guidelines recommendations, the diagnostic criteria and terminology of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was slowly adopted in the local settings...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29161779/micronuclei-assay-in-exfoliated-buccal-cells-of-radiation-treated-oral-cancer-patients
#2
Gayathri Ramesh, Smriti Chaubey, Amrita Raj, Ravi Kumar Seth, Anuradha Katiyar, Amit Kumar
BACKGROUND: Micronuclei are suitable internal dosimeters for revealing tissue-specific genotoxic damage in individuals exposed to carcinogenic mixtures. Evaluation of radiation-induced cellular changes to predict radiosensitivity has invested many investigators since such changes were first found in biopsy material. AIM: The aim of the present study was to assess the relationship of with histopathological grade and number of radiation therapy sittings with the frequency of micronuclei and nuclear anomalies among oral cancer patients...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161776/awareness-on-cytology-procedure-in-oral-cancer-detection-among-undergraduates-an-institutional-study
#3
Gayathri Ramesh, Rajeev Pathak, Sunita Pathak, Amrita Raj, Amit Kumar, Anuradha Katiyar
Background: The screening and the early detection of the premalignant and malignant lesions are the only means for controlling the oral cancer which is known to be one of the leading causes for mortality worldwide. Oral exfoliative cytology though not a substitute for biopsy can be a powerful tool for its early detection. Dental Surgeons can play a great role in this direction. Aims and Objectives: The present study was undertaken to assess the self-reported knowledge and attitude regarding the early detection of oral cancer and exfoliative cytology among the undergraduates of Rama Dental College, Kanpur...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161285/hpv-genotypes-co-infections-associated-with-cervical-carcinoma-special-focus-on-phylogenetically-related-and-non-vaccine-targeted-genotypes
#4
Rashmirani Senapati, Bhagyalaxmi Nayak, Shantanu Kumar Kar, Bhagirathi Dwibedi
HPV is the major causative agent for cervical cancer. Study on the risk of cervical cancer associated with different hr-HPV genotypes would be useful for disease management and new vaccine strategy. With limited reports available, the present study aimed to investigate the pattern of HPV genotypes coinfections and risk of cervical carcinoma associated with them in Indian population. 15 HPV genotypes were detected by E6/E7 multiplex nested type-specific PCR in the HPV-positive cervical samples of 172 cervical cancer cases and 174 subjects with normal cytology...
2017: PloS One
https://www.readbyqxmd.com/read/29160903/smoking-cessation-leads-to-changes-in-survivin-expression-in-oral-mucosa
#5
Celina Faig Lima, Erica Crastechini, Nathalia Curto Dos Santos, Ana Carolina Prado Ribeiro, Thais Bianca Brandão, Félix Cristiano Ferreira de Castro, Jaqueline Scholz Issa, Janete Dias Almeida
BACKGROUND: Survivin is an inhibitor protein of apoptosis and play a role in oral carcinogenesis mechanism. METHODS: This aim of this study was to evaluate the effect of smoking in survivin expression of oral mucosa of chronic smokers with and without oral squamous cell carcinoma (OSCC). The study was composed of three groups: Group 1 - 26 patients smoking more than 20 cigarettes/day/10 years without either history of oral malignant neoplasia or visible clinical signs in the examined site; Group 2 - 26 patients with OSCC; Group 3 - 22 patients surgically treated for OSCC for at least 1 month...
November 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29160722/do-infection-patterns-of-human-papillomavirus-affect-the-cytologic-detection-of-high-grade-cervical-lesions-on-papanicolaou-tests
#6
Siavash Azadmanesh Samimi, Roxanne R Mody, Steven Goodman, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina R Mody, Yimin Ge
CONTEXT: - Persistent infection with high-risk human papillomavirus (hrHPV) is the major cause of cervical cancer. The effect of HPV infection patterns on cytologic detection of cervical lesions is unknown. OBJECTIVE: - To determine the effect of HPV infection patterns on the sensitivity of cytologic detection of high-grade cervical lesions. DESIGN: - Papanicolaou tests from 257 women with biopsy-confirmed, high-grade squamous intraepithelial lesions were analyzed with respect to HPV infection patterns...
November 21, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29160214/auer-rod-like-inclusions-in-non-blast-cells
#7
Alexandra Chapuis, Safia Chebrek, Hélène Lefrand, Anne-Laure Chesnais, Guillaume Granier, Hacène Zerazhi, Elisabeth André-Kerneïs
We report a 69-year-old adult case with a monoclonal gammopathy incidentally discovered, associated with a moderate thrombocytopenia of 90 G/L. Study of blood smear revealed the presence of tumor cells presenting Auer rod-like inclusions, although there were not blast cells. Blood cytology as well as immunophenotyping allowed us to make the diagnosis of malignant hemopathy.
November 21, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29160163/cancer-risk-associated-with-nuclear-atypia-in-cytologically-indeterminate-thyroid-nodules-a-systematic-review-and-meta-analysis
#8
Pablo Valderrabano, Laila Khazai, Zachary J Thompson, Susan C Sharpe, Valentina D Tarasova, Kristen J Otto, Julie E Hallanger-Johnson, J Trad Wadsworth, Bruce M Wenig, Christine H Chung, Barbara A Centeno, Bryan McIver
BACKGROUND: Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. We assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nuclear atypia...
November 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29159260/public-health-approach-to-prevent-cervical-cancer-in-hiv-infected-women-in-kenya-issues-to-consider-in-the-design-of-prevention-programs
#9
REVIEW
Sonia Menon, Rodolfo Rossi, Stacy G Harmon, Hillary Mabeya, Steven Callens
Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29158102/human-papillomavirus-types-from-infection-to-cancer-in-the-anus-according-to-sex-and-hiv-status-a-systematic-review-and-meta-analysis
#10
Chunqing Lin, Silvia Franceschi, Gary M Clifford
BACKGROUND: Data on carcinogenicity of human papillomavirus (HPV) types in the anus are needed to inform anal cancer prevention through vaccination and screening. This is particularly the case for people infected with HIV, who are at an increased risk of anal cancer. METHODS: We did a systematic review of studies published from January, 1986, to July, 2017, in MEDLINE, Embase, and the Cochrane Library on anal HPV infection, without any language restrictions. Eligible studies reported type-specific HPV prevalence by strata of cytopathological or histopathological anal diagnosis, sex, and HIV status...
November 17, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29157376/epidemiological-and-partial-budget-analysis-for-treatment-of-subclinical-staphylococcus-aureus-intramammary-infections-considering-microbiological-and-cytological-scenarios
#11
Inge-Marié Petzer, Eric M C Etter, Edward F Donkin, Edward C Webb, Joanne Karzis
An innovative method was investigated to aid in the elimination of Staphylococcus aureus (S. aureus) intramammary infections (IMI) from dairy herds. A stochastic model explore the economic benefit of three-day or eight-day treatment of subclinical IMI in all S. aureus infected cows or in only those with a somatic cell count (SCC) exceeding 200,000 cells/ml. An epidemiological model was developed to run parallel to the economic model that would predict the S. aureus IMI likely to persist, develop new infections and clinical mastitis...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29157213/phylogeny-and-maternal-donors-of-elytrigia-desv-sensu-lato-triticeae-poaceae-inferred-from-nuclear-internal-transcribed-spacer-and-trnl-f-sequences
#12
Yan Yang, Xing Fan, Long Wang, Hai-Qin Zhang, Li-Na Sha, Yi Wang, Hou-Yang Kang, Jian Zeng, Xiao-Fang Yu, Yong-Hong Zhou
BACKGROUND: Elytrigia Desv. is a genus with a varied array of morphology, cytology, ecology, and distribution in Triticeae. Classification and systematic position of Elytrigia remain controversial. We used nuclear internal-transcribed spacer (nrITS) sequences and chloroplast trnL-F region to study the relationships of phylogenetic and maternal genome donor of Elytrigia Desv. sensu lato. RESULTS: (1) E, F, P, St, and W genomes bear close relationship with one another and are distant from H and Ns genomes...
November 21, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29157067/role-of-endoscopic-ultrasound-in-the-management-of-tubercular-uveitis
#13
Deepa Sharma, Manisha Agarwal, Vikas Singla, Vivek Jha, Ankita Shrivastav
PURPOSE: To evaluate the role and safety of endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) in patients of tubercular uveitis. DESIGN: Interventional case series Methods: Thirty patients suspected of tubercular uveitis that underwent EUS-FNAC were enrolled in the study. The patient details recorded were age, gender, systemic history, ocular complaints and clinical manifestations. The details of the investigations - skin test, X-Ray chest, CECT (contrast enhanced computed tomography) of chest and findings on EUS-FNAC were also recorded...
November 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29156081/cervical-hpv-prevalence-and-genotype-distribution-in-immunosuppressed-danish-women
#14
Mette T Roensbo, Jan Blaakaer, Karin Skov, Anne Hammer
INTRODUCTION: Women receiving immunosuppressive treatment due to organ transplantation are at increased risk of Human papilloma virus (HPV)-related diseases, including cervical neoplasia. This pilot study aimed to describe the cervical HPV prevalence and genotype distribution in immunosuppressed Danish women. MATERIAL AND METHODS: We included women who underwent renal- (RTR) or bone marrow transplantation (BMTR) in 2009-2012 or 2014 at Aarhus University Hospital, Denmark...
November 20, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29155208/inflammatory-renin-angiotensin-system-disruption-attenuates-sensory-hyperinnervation-and-mechanical-hypersensitivity-in-a-rat-model-of-provoked-vestibulodynia
#15
Anuradha Chakrabarty, Zhaohui Liao, Ying Mu, Peter G Smith
Vestibulodynia is characterized by peri-vaginal mechanical hypersensitivity, hyperinnervation, and abundant inflammatory cells expressing renin-angiotensin system proteins. We developed a tractable rat model of vestibulodynia to further assess the contributions of the renin-angiotensin system. Complete Freund's adjuvant (CFA) injected into the posterior vestibule induced marked vestibular hypersensitivity throughout a 7-day test period. Numbers of axons immunoreactive for PGP9.5, calcitonin gene-related peptide, and GFRα2 were increased...
November 15, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29154972/impact-of-rapid-on-site-cytological-evaluation-rose-on-the-diagnostic-yield-of-transbronchial-needle-aspiration-during-mediastinal-lymph-node-sampling-systematic-review-and-meta-analysis
#16
Inderpaul Singh Sehgal, Sahajal Dhooria, Ashutosh Nath Aggarwal, Ritesh Agarwal
BACKGROUND: Whether the use of rapid onsite cytological evaluation (ROSE) increases the diagnostic yield of transbronchial needle aspiration (TBNA) remains unclear. Herein, we perform a systematic review of studies describing the utility of ROSE in subjects undergoing TBNA. METHODS: Systematic review of PubMed, EmBase and Scopus databases for RCTs investigating the diagnostic yield of conventional TBNA (c-TBNA) or endobronchial ultrasound (EBUS)-TBNA, with or without ROSE, in subjects with mediastinal lymphadenopathy...
November 15, 2017: Chest
https://www.readbyqxmd.com/read/29154448/significance-of-bizarre-cells-in-cervical-screening-liquid-based-cytology-a-prospective-study-of-15-cases
#17
O Ondič, R Ferko, J Kičinová, J Bouda, I Kinkorová-Luňáčková, L Kupcová, M Zůchová, J Chytra, T Waloschek, M Tůmová Bartošková, R Alaghehbandan, J Němcová
OBJECTIVE: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation. METHODS: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep(®) LBC workload...
November 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29154376/post-irradiation-vaginal-spindle-cell-sarcoma
#18
A Kalogeraki, C Ximeris, V Ximeri, D Tamiolakis, G Milaki, M Kafousi
The genetic profile is one of the major possible causes of spindle cell sarcoma. Irradiation has also been linked to this type of cancer. This means that if tissues have already been irradiated for other types of cancer, they can afterwards develop this form of sarcoma. Also, previous radiotherapy can determine specific genetic alterations, which result to uncontrolled cell division, that is neoplasia. We report one such cause in a female patient 80 years old with a uterus adenocarcinoma (endometrioid type) FIGO Stage IC, who had been treated with surgical resection and pelvic irradiation...
September 2017: Pathologica
https://www.readbyqxmd.com/read/29153962/sonographic-criteria-predictive-of-malignant-thyroid-nodules-which-lesions-should-be-biopsied
#19
Carlos Miguel Oliveira, Rui Alves Costa, Miguel Patrício, Amélia Estêvão, Bruno Graça, Filipe Caseiro-Alves
RATIONALE AND OBJECTIVES: The objective of this study was to evaluate the ultrasound features of thyroid nodules and their association with malignancy, focusing on establishing feature-oriented ultrasound criteria to determine proper management of a thyroid nodule. MATERIALS AND METHODS: A sample of 379 thyroid nodules were biopsied (from a total of 357 patients aged 59.8 ± 14.8 years) and 300 were included in the final study (271 benign nodules and 29 malignant ones)...
November 16, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29151949/cerebrospinal-fluid-proteins-identification-facilitates-the-differential-diagnosis-of-central-nervous-system-diffuse-large-b-cell-lymphoma
#20
Wen Zheng, YuQin Song, Yan Xie, NingJing Lin, MeiFeng Tu, WeiPing Liu, LingYan Ping, ZhiTao Ying, Chen Zhang, LiJuan Deng, XiaoPei Wang, YouYong Lu, Jun Zhu
Background: Diagnosis of central nervous system (CNS) lymphoma remains a challenge. This study aimed to identify cerebrospinal fluid (CSF) proteins that distinguish patients with and without CNS lymphoma. Methods: We used one-dimensional SDS-polyacrylamide gel electrophoresis coupled with liquid chromatography- electrospray ionization-quadrupole-time of flight-mass spectrometry (LC-ESI-Q-TOF MS) to identify CSF proteins in CNS diffuse large B cell lymphoma (DLBCL) patients and controls. Results: Approximately 166 CSF proteins were identified, 12 for the first time in the CSF of lymphoma patients...
2017: Journal of Cancer
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