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https://www.readbyqxmd.com/read/28637156/the-sink-or-swim-hypothesis-a-roadmap-from-pathology-to-work-instability
#1
Bilal Akter Mateen, Catherine Doogan, Kate Hayward, Susan Hourihan, Joanne Hurford, E Diane Playford
PURPOSE: Selecting the most appropriate health-related work outcome to evaluate an intervention can be fraught with difficulty. To aid clinicians in navigating this problem we have developed a model, which illustrates how pathology can affect specific measureable quantities, such as work instability. METHODS: Using a modified-Delphi procedure, a panel of experts met initially to analyze the content of 95 health-related work outcome measures and organize the identified areas of measurement into a coherent model, complemented by a narrative review of the literature...
March 3, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28637137/development-and-acceptability-testing-of-decision-trees-for-self-management-of-prosthetic-socket-fit-in-adults-with-lower-limb-amputation
#2
Daniel Joseph Lee, Diana A Veneri
PURPOSE: The most common complaint lower limb prosthesis users report is inadequacy of a proper socket fit. Adjustments to the residual limb-socket interface can be made by the prosthesis user without consultation of a clinician in many scenarios through skilled self-management. Decision trees guide prosthesis wearers through the self-management process, empowering them to rectify fit issues, or referring them to a clinician when necessary. This study examines the development and acceptability testing of patient-centered decision trees for lower limb prosthesis users...
February 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28636967/a-few-good-commensals-gut-microbes-use-ifn-%C3%AE-to-fight-salmonella
#3
Kyla S Ost, June L Round
Whereas strong evidence supports the notion that the microbiota promotes immune system maturation in multiple tissues, the identity of the specific microbes that elicit protective immunity to different infections is less clear. In a recent issue of Cell Host & Microbe, Thiemann et al. (2017) report the identification of specific gut bacteria that protect from Salmonella infection by priming host IFN-γ responses.
June 20, 2017: Immunity
https://www.readbyqxmd.com/read/28636793/development-and-validation-of-ihs4-a-novel-dynamic-scoring-system-to-assess-hidradenitis-suppurativa-acne-inversa-severity
#4
C C Zouboulis, T Tzellos, A Kyrgidis, G B E Jemec, F G Bechara, E J Giamarellos-Bourboulis, J R Ingram, T Kanni, I Karagiannidis, A Martorell, Ł Matusiak, A Pinter, E P Prens, D Presser, S Schneider-Burrus, E von Stebut, J C Szepietowski, H H van der Zee, S M Wilden, R Sabat
BACKGROUND: A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system. METHODS: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicenter prospective study...
June 21, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28636361/a-machine-learning-assisted-approach-for-discovering-novel-inhibitors-targeting-bromodomain-containing-protein-4
#5
Jing Xing, Wenchao Lu, Rongfeng Liu, Yulan Wang, Yiqian Xie, Hao Zhang, Zhe Shi, Hao Jiang, Yu-Chih Liu, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Bromodomain-containing protein 4 (BRD4) is implicated in the pathogenesis of a number of different cancers, inflammatory diseases and heart failure. Much effort has been dedicated toward discovering novel scaffold BRD4 inhibitors (BRD4is) with different selectivity profiles and potential anti-resistance properties. Structure-based drug design (SBDD) and virtual screening (VS) are the most frequently used approaches. Here, we demonstrate a novel, structure-based VS approach that uses machine-learning algorithms trained on the priori structure and activity knowledge to predict the likelihood that a compound is a BRD4i based on its binding pattern with BRD4...
June 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28634746/screening-and-identification-of-a-specific-peptide-binding-to-cervical-cancer-cells-from-a-phage-displayed-peptide-library
#6
Chunyan Li, Ning Gao, Qinqin Xue, Ni Ma, Yuqin Hu, Jianfang Zhang, Biliang Chen, Yingchun Hou
OBJECTIVES: To screen and identify the probe markers specifically binding to human cervical cancer, a phage-displayed 12-mer peptide library was used for biopanning of SiHa cells. RESULTS: After four rounds of whole-cell subtraction biopanning, the phage recovery was 21-fold higher (from 3.9 × 10(-5) to 8.3 × 10(-4)) than that of the first round, and specific phage clones were significantly enriched. 57 randomly selected phage clones were tested by ELISA, and 36 phage clones were identified as positive clones...
June 20, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28634628/standardizing-hysteroscopy-teaching-development-of-a-curriculum-using-the-delphi-method
#7
Marie-Emmanuelle Neveu, Elodie Debras, Julien Niro, Hervé Fernandez, Pierre Panel
BACKGROUND: Hysteroscopy is performed often and in many indications but is challenging to learn. Hands-on training in live patients faces ethical, legal, and economic obstacles. Virtual reality simulation may hold promise as a hysteroscopy training tool. No validated curriculum specific in hysteroscopy exists. The aim of this study was to develop a hysteroscopy curriculum, using the Delphi method to identify skill requirements. METHODS: Based on a literature review using the key words "curriculum," "simulation," and "hysteroscopy," we identified five technical and non-technical areas in which skills were required...
June 20, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28634618/ct-and-mri-findings-in-focal-eosinophilic-infiltration-of-the-liver
#8
Bao-Liang Guo, Qiu-Gen Hu, Fu-Sheng Ouyang, Bin Zhang, Yu-Hao Dong, Xiao-Ning Luo, Zhou-Yang Lian, Shui-Xing Zhang
OBJECTIVES: To investigate the findings of computed tomography (CT) and magnetic resonance imaging (MRI) of focal eosinophilic infiltration (FEI) of the liver. METHODS: A retrospective study including 29 patients with confirmed FEI of the liver was performed. We evaluated the lesions' number, distribution, size, shape, margin, attenuation or signal intensity characteristics, the enhancement pattern, and some special features. Spearman correlation analysis was used to analyze the correlation between the number of lesions and the eosinophil counts in peripheral blood...
June 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28633959/characterization-of-the-superior-olivary-complex-of-canis-lupus-domesticus
#9
Tatiana Fech, Lilian Calderón-Garcidueñas, Randy J Kulesza
The superior olivary complex (SOC) is a collection of brainstem auditory nuclei which play essential roles in the localization of sound sources, temporal coding of vocalizations and descending modulation of the cochlea. Notwithstanding, the SOC nuclei vary considerably between species in accordance with the auditory needs of the animal. The canine SOC was subjected to anatomical and physiological examination nearly 50 years ago and was then virtually forgotten. Herein, we aimed to characterize the nuclei of the canine SOC using quantitative morphometrics, estimation of neuronal number, histochemistry for perineuronal nets and immunofluorescence for the calcium binding proteins calbindin and calretinin...
June 15, 2017: Hearing Research
https://www.readbyqxmd.com/read/28633925/the-discovery-of-plasma-cells-an-historical-note
#10
REVIEW
Domenico Ribatti
The name plasma cell was introduced by the anatomist Heinrich H. von Hartz-Waldeyer in 1875. Plasma cells derive from small B lymphocytes after their activation. A fully mature plasma cell lacks surface immunoglobulin expression. Its form is round or oval, with characteristic basophilic cytoplasm and an eccentric nucleus that contains coarse heterochromatin. Antigen activation of mature B cells leads initially to germinal center development, the transient generation of plasmablasts that secrete antibody while still dividing, and short-lived extrafollicular plasma cells that secrete antigen-specific germ line-encoded antibodies...
June 17, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28633888/burden-of-acute-gastroenteritis-caused-by-norovirus-in-china-a-systematic-review
#11
Hong-Lu Zhou, Shan-Shan Zhen, Jin-Xia Wang, Can-Jing Zhang, Chao Qiu, Song-Mei Wang, Xi Jiang, Xuan-Yi Wang
BACKGROUND: To understand the epidemiology and disease burden of norovirus (NoVs) gastroenteritis in China, a systematic review was conducted. METHODS: Studies on acute gastroenteritis (AGE) caused by NoVs from mainland China, published before 2017 were searched. All retrieved articles were screened and reviewed by a standardized algorithm. NoVs detection rates as well as strain variations by ages, seasonal variations and geographic locations were analyzed using random-effects model...
June 17, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28633781/beaming-in-charcot-arthropathy-intramedullary-fixation-for%C3%A2-complicated-reconstructions-a-cadaveric-study
#12
Corey M Fidler, Benjamin C Watson, Christopher W Reb, Christopher F Hyer
In the modern treatment of Charcot neuroarthropathy, beam screw fixation is an alternative to plate and screw fixation. Exposure is minimized for implantation, and this technique supports the longitudinal columns of the foot as a rigid load-sharing construct. A published data review identified a paucity of data regarding metatarsal intramedullary canal morphology relevant to beam screw fixation. The purpose of the present study was to describe metatarsal diaphyseal morphology qualitatively and quantitatively in an effort to provide data that can be used by surgeons when selecting axially based intramedullary fixation...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633775/ball-and-socket-ankle-mechanism-and-computational-evidence-of-concept
#13
James R Jastifer, Peter A Gustafson, Aaron Labomascus, Tyler Snoap
The ball and socket ankle joint is a morphologically abnormal joint characterized by rounding of the articular surface of the talus. Other than anecdotal observation, little evidence has been presented to describe the development of this deformity. The purpose of the present study was to review ankle and subtalar joint mechanics and to kinematically examine the functional combination of these joints as a mechanism of the ball and socket ankle deformity. We reviewed functional representations of the ankle joint, subtalar joint, and ball and socket ankle deformity...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633739/autoimmune-progesterone-dermatitis-presenting-as-fixed-drug-eruption-a-case-report
#14
Raya Mokhtari, Mozhdeh Sepaskhah, Fatemeh Sari Aslani, Ladan Dastgheib
Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. These skin eruptions waxed and waned for 10 months, reoccurring 3-4 days before menstruation...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28633124/mesothelial-cyst-in-the-liver-round-ligament-a-case-report-and-review-of-the-literature
#15
Claudio F Feo, Giorgio C Ginesu, Giuseppe Cherchi, Alessandro Fancellu, M Laura Cossu, Alberto Porcu
INTRODUCTION: Cysts of the liver round ligament are rare and they are benign in the majority of cases. Current literature has been reviewed on this subject. PRESENTATION OF CASE: A 22-year-old woman with a history of epigastric pain was admitted at our institution. Computed tomography (CT) of the abdomen showed a 14-mm cystic lesion in the epigastrium. A large cyst of the liver round ligament was successfully removed during exploratory laparoscopy and histopathology revealed a benign mesothelial cyst...
June 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28632899/novel-intracytoplasmic-inclusions-immunoreactive-for-phosphorylated-tdp43-and-cystatin-c-in-anterior-horn-cells-in-a-case-of-sporadic-amyotrophic-lateral-sclerosis
#16
Masayuki Shintaku, Daita Kaneda, Kiyomitsu Oyanagi
Novel intracytoplasmic inclusions immunoreactive for phosphorylated transactivation response DNA-binding protein 43 (p-TDP43), cystatin C, and transferrin were found in anterior horn cells in a case of sporadic amyotrophic lateral sclerosis (ALS). The patient was a 59-year-old woman, who died of ALS after a clinical course of 8 years. She had been receiving mechanical support for respiration for 6 years and in a "totally locked-in" state for 4 years prior to death. The spinal cord showed severe degeneration involving the anterior and lateral funiculi, whereas the posterior funiculus was preserved...
June 20, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28632642/letter-to-the-prs-editor-comparing-round-and-anatomically-shaped-implants-in-augmentation-mammaplasty-the-experts-ability-to-differentiate-the-type-of-implant
#17
Mark L Jewell
No abstract text is available yet for this article.
June 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28632641/letter-to-prs-editor-comparing-round-and-anatomically-shaped-implants-in-augmentation-mammoplasty-the-experts-ability-to-differentiate-the-type-of-implant
#18
Carlos G Rubi, Jose Angel Lozano, Alberto Pérez-Espadero, Elena Leache
No abstract text is available yet for this article.
June 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28632639/letter-to-prs-editor-re-comparing-round-and-anatomically-shaped-implants-in-augmentation-mammoplasty-the-experts-ability-to-differentiate-the-type-of-implant
#19
Carlos G Rubi, Elena Leache, Jose Angel Lozano, Alberto Pérez-Espadero
No abstract text is available yet for this article.
June 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28632637/comparing-round-and-anatomically-shaped-implants-in-augmentation-mammaplasty-the-experts-ability-to-differentiate-the-type-of-implant
#20
Mouchammed Agko, Per Hedén
No abstract text is available yet for this article.
June 15, 2017: Plastic and Reconstructive Surgery
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