keyword
MENU ▼
Read by QxMD icon Read
search

Pharyngeal cancer

keyword
https://www.readbyqxmd.com/read/27917295/circulating-human-papillomavirus-dna-detected-using-droplet-digital-pcr-in-the-serum-of-patients-diagnosed-with-early-stage-human-papillomavirus-associated-invasive-carcinoma
#1
Emmanuelle Jeannot, Véronique Becette, Maura Campitelli, Marie-Ange Calméjane, Emmanuelle Lappartient, Evelyne Ruff, Stéphanie Saada, Allyson Holmes, Dominique Bellet, Xavier Sastre-Garau
Specific human papillomavirus genotypes are associated with most ano-genital carcinomas and a large subset of oro-pharyngeal carcinomas. Human papillomavirus DNA is thus a tumour marker that can be detected in the blood of patients for clinical monitoring. However, data concerning circulating human papillomavirus DNA in cervical cancer patients has provided little clinical value, due to insufficient sensitivity of the assays used for the detection of small sized tumours. Here we took advantage of the sensitive droplet digital PCR method to identify circulating human papillomavirus DNA in patients with human papillomavirus-associated carcinomas...
October 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27889616/developments-in-l2-based-human-papillomavirus-hpv-vaccines
#2
REVIEW
Christina Schellenbacher, Richard B S Roden, Reinhard Kirnbauer
Infections with sexually transmitted high-risk Human Papillomavirus (hrHPV), of which there are at least 15 genotypes, are responsible for a tremendous disease burden by causing cervical, and subsets of other ano-genital and oro-pharyngeal carcinomas, together representing 5% of all cancer cases worldwide. HPV subunit vaccines consisting of virus-like particles (VLP) self-assembled from major capsid protein L1 plus adjuvant have been licensed. Prophylactic vaccinations with the 2-valent (HPV16/18), 4-valent (HPV6/11/16/18), or 9-valent (HPV6/11/16/18/31/33/45/52/58) vaccine induce high-titer neutralizing antibodies restricted to the vaccine types that cause up to 90% of cervical carcinomas, a subset of other ano-genital and oro-pharyngeal cancers and 90% of benign ano-genital warts (condylomata)...
November 23, 2016: Virus Research
https://www.readbyqxmd.com/read/27861932/residue-influences-quality-of-life-independently-of-penetration-and-aspiration-in-head-and-neck-cancer-survivors
#3
Tanya K Meyer, Jessica M Pisegna, Gintas P Krisciunas, Barbara R Pauloski, Susan E Langmore
OBJECTIVES/HYPOTHESIS: Dysphagia is one of the most significant side effects of the treatment of head and neck cancer. Residue and aspiration are two indicators of dysphagia, but aspiration is historically the only indicator of interest, because it may impact health outcomes. Clinicians have anecdotally used residue as another marker of swallowing dysfunction, but it is understudied. This project investigated the impact of aspiration versus residue on function and quality of life (QoL) in these patients...
November 9, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27846899/contribution-of-submandibular-gland-and-swallowing-structure-sparing-to-post-radiation-therapy-peg-dependence-in-oropharynx-cancer-patients-treated-with-split-neck-imrt-technique
#4
Michael F Gensheimer, Matthew Nyflot, George E Laramore, Jay J Liao, Upendra Parvathaneni
BACKGROUND: Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of this study was to determine whether SMG sparing IMRT is associated with reduced post-treatment PEG dependence in locally advanced oropharynx cancer patients. METHODS: Patients treated with definitive radiation therapy for oropharynx cancer were included in this retrospective study...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27829737/overview-of-immunology-of-oral-squamous-cell-carcinoma
#5
REVIEW
Anisha Cynthia Sathiyasekar, Pavithra Chandrasekar, Arul Pakash, K U Goma Kumar, M S Jaishlal
Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy and is a major cause of cancer morbidity and mortality worldwide. Every year, approximately 500,000 new cases of oral and pharyngeal cancers are diagnosed worldwide, and a majority of these cases are seen in developing countries. OSCC arises as a result of multiple molecular events that develop from the combined influences of an individual's genetic predisposition and exposure to environmental carcinogens. Here, we discuss the course of immunological development involving OSCC...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27812692/radiotherapy-characteristics-and-outcomes-for-head-and-neck-carcinoma-of-unknown-primary-vs-t1-base-of-tongue-carcinoma
#6
Ali Hosni, Peter R Dixon, Anupam Rishi, Michael Au, Wei Xu, Yuyao Song, Douglas B Chepeha, David P Goldstein, Shao Hui Huang, John Kim, Brian O'Sullivan, John Waldron, Scott V Bratman, John R de Almeida
Importance: Transoral robotic surgery- or transoral laser microsurgery-assisted lingual tonsillectomy may improve the identification rate of hidden base-of-tongue (BOT) carcinoma presenting as head or neck carcinoma of unknown primary (CUP) site. Objective: To evaluate the potential impact of lingual tonsillectomy in CUP site by comparing differences in radiotherapy volumes, dosimetry, and clinical outcomes for CUP site and T1-category BOT carcinoma. Design, Setting, and Participants: Retrospective study of 115 patients treated at a tertiary cancer center between January 1, 2005, and December 31, 2013, that included patients with BOT carcinoma (category T1N1-3M0) and CUP site (category T0N1-3M0) with known p16 status...
November 3, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27805282/toll-like-receptor-3-stimulation-triggers-metabolic-reprogramming-in-pharyngeal-cancer-cell-line-through-myc-mapk-and-hif
#7
Tanja Matijevic Glavan, Ana Cipak Gasparovic, Benjamin Vérillaud, Pierre Busson, Jasminka Pavelic
Toll-like receptor 3 (TLR3) has a dual role in cancer; its activation can trigger apoptosis as well as stimulate cancer cell survival, proliferation, and progression. We have shown here that TLR3 activation can induce metabolic reprogramming in a pharyngeal cancer cell line, leading to increased aerobic glycolysis, cell migration, elevated levels of reactive oxidative species (ROS), and decreased anti-oxidative response. Key proteins in these signaling pathways are heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), pyruvate kinase M2 (PKM2), and CD44 variants, which were over-expressed after TLR3 stimulation...
November 2, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27789194/carotid-blowout-syndrome-in-patients-treated-by-larynx-cancer
#8
Carlos Miguel Chiesa Estomba, Frank Alberto Betances Reinoso, Alejandra Osorio Velasquez, Olalla Castro Macia, Maria Jesus Gonzalez Cortés, Jesus Araujo Nores
INTRODUCTION: Carotid blowout syndrome is an uncommon complication for patient treated by head and neck tumours, related with a high mortality rate. OBJECTIVE: The aim of this study was to study the risk of carotid blowout in a large cohort of patients treated only by larynx cancer. METHODS: Retrospective analysis of patients older than 18 years, treated by larynx cancer who developed a carotid blowout syndrome in a tertiary academic centre...
September 29, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27780384/predicting-feeding-tube-and-tracheotomy-dependence-in-laryngeal-cancer-patients
#9
John Patrick Lavo, David Ludlow, Matt Morgan, Gloria Caldito, Cherie-Ann Nathan
CONCLUSIONS: The two scales reliably measure laryngeal edema and dysfunction in laryngeal cancer patients. The eight categories from these scales, and abnormal pharyngeal squeeze, can be used to form a new rating scale intended to help clinicians identify and circumvent swallowing complications after chemo-irradiation. OBJECTIVES: The objectives were to compare two laryngeal edema rating scales in laryngeal cancer patients and determine if post-radiation +/- chemotherapy edema predicts dependence on a feeding tube and/or tracheostomy...
October 26, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27780233/a-comprehensive-analysis-on-the-association-between-tobacco-free-betel-quid-and-risk-of-head-and-neck-cancer-in-taiwanese-men
#10
Yuan-Hua Wu, Chia-Jui Yen, Jenn-Ren Hsiao, Chun-Yen Ou, Jehn-Shyun Huang, Tung-Yiu Wong, Sen-Tien Tsai, Cheng-Chih Huang, Wei-Ting Lee, Ken-Chung Chen, Sheen-Yie Fang, Jiunn-Liang Wu, Wei-Ting Hsueh, Forn-Chia Lin, Ming-Wei Yang, Jang-Yang Chang, Hsiao-Chen Liao, Shang-Yin Wu, Chen-Lin Lin, Yi-Hui Wang, Ya-Ling Weng, Han-Chien Yang, Yu-Shan Chen, Jeffrey S Chang
OBJECTIVES: Although betel quid (BQ) is an established risk factor of head and neck cancer (HNC), insufficiencies exist in the literature regarding the dose-response, BQ types, HNC sites, and BQ cessation. The current study was conducted to fill these insufficiencies. MATERIALS AND METHODS: A hospital-based case-control study was conducted to evaluate the association between BQ and HNC. In-person interview was conducted to collect data on BQ chewing. The current analysis included 487 men newly diagnosed with HNC and 617 male controls who were frequency-matched to the cases by age...
2016: PloS One
https://www.readbyqxmd.com/read/27774922/clinical-and-histopathological-prognostic-factors-in-locoregional-advanced-laryngeal-cancer
#11
T S Santos, R Estêvão, L Antunes, V Certal, J C Silva, E Monteiro
OBJECTIVE: To evaluate the clinical and histopathological factors affecting the prognosis of patients with squamous cell locoregional advanced laryngeal cancer. METHODS: A retrospective chart review was conducted of 121 patients with locoregional advanced laryngeal cancer, primarily treated with surgery from 2007 to 2011. Disease-free survival and overall survival rates were analysed as oncological outcomes. Prognostic variables, namely gender, pharyngeal invasion, pathological assessment of tumour and nodal stage, adjuvant therapy, margin status, nodal extracapsular extension, tumour differentiation, lymphovascular and perineural invasion, and predominant growth pattern, were also analysed...
October 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27764170/clinical-implications-of-fadd-gene-amplification-and-protein-overexpression-in-taiwanese-oral-cavity-squamous-cell-carcinomas
#12
Huei-Tzu Chien, Sou-De Cheng, Wen-Yu Chuang, Chun-Ta Liao, Hung-Ming Wang, Shiang-Fu Huang
Amplification of 11q13.3 is a frequent event in human cancers, including head and neck squamous cell carcinoma. This chromosome region contains several genes that are potentially cancer drivers, including FADD (Fas associated via death domain), an apoptotic effector that was previously identified as a novel oncogene in laryngeal/pharyngeal cancer. This study was designed to explore the role of FADD in oral squamous cell carcinomas (OSCCs) samples from Taiwanese patients, by assessing copy number variations (CNVs) and protein expression and the clinical implications of these factors in 339 male OSCCs...
2016: PloS One
https://www.readbyqxmd.com/read/27762071/immunohistochemical-studies-and-fluorodeoxyglucose-uptake-on-positron-emission-tomography-in-pharyngeal-cancer-for-predicting-radiotherapy-based-treatment-outcomes
#13
Y-C Lin, R-Y Chen, S-W Chen, T-C Hsieh, K-Y Yen, J-A Liang, S-N Yang, Y-C Wang, Y-H Chen, N-H Chow, C-H Kao
OBJECTIVES: This study correlated immunohistochemical studies with fluorodeoxyglucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) and identified prognostic factors for radiotherapy (RT)-based treatment outcomes in patients with squamous cell carcinoma of the oropharynx and hypopharynx. METHODS: Genomic data from pre-treatment biopsy specimens (Glut1, CAIX, VEGF, HIF-1α, EGFR, Ki-67, Bcl-2, CLAUDIN-4, YAP-1, c-Met and p16) of 76 patients were analysed using tissue microarrays...
October 20, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27749845/genome-wide-association-analyses-identify-new-susceptibility-loci-for-oral-cavity-and-pharyngeal-cancer
#14
Corina Lesseur, Brenda Diergaarde, Andrew F Olshan, Victor Wünsch-Filho, Andrew R Ness, Geoffrey Liu, Martin Lacko, José Eluf-Neto, Silvia Franceschi, Pagona Lagiou, Gary J Macfarlane, Lorenzo Richiardi, Stefania Boccia, Jerry Polesel, Kristina Kjaerheim, David Zaridze, Mattias Johansson, Ana M Menezes, Maria Paula Curado, Max Robinson, Wolfgang Ahrens, Cristina Canova, Ariana Znaor, Xavier Castellsagué, David I Conway, Ivana Holcátová, Dana Mates, Marta Vilensky, Claire M Healy, Neonila Szeszenia-Dąbrowska, Eleonóra Fabiánová, Jolanta Lissowska, Jennifer R Grandis, Mark C Weissler, Eloiza H Tajara, Fabio D Nunes, Marcos B de Carvalho, Steve Thomas, Rayjean J Hung, Wilbert H M Peters, Rolando Herrero, Gabriella Cadoni, H Bas Bueno-de-Mesquita, Annika Steffen, Antonio Agudo, Oxana Shangina, Xiangjun Xiao, Valérie Gaborieau, Amélie Chabrier, Devasena Anantharaman, Paolo Boffetta, Christopher I Amos, James D McKay, Paul Brennan
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34...
December 2016: Nature Genetics
https://www.readbyqxmd.com/read/27744388/smokeless-tobacco-use-and-the-risk-of-head-and-neck-cancer-pooled-analysis-of-us-studies-in-the-inhance-consortium
#15
Annah B Wyss, Mia Hashibe, Yuan-Chin Amy Lee, Shu-Chun Chuang, Joshua Muscat, Chu Chen, Stephen M Schwartz, Elaine Smith, Zuo-Feng Zhang, Hal Morgenstern, Qingyi Wei, Guojun Li, Karl T Kelsey, Michael McClean, Deborah M Winn, Stimson Schantz, Guo-Pei Yu, Maura L Gillison, Jose P Zevallos, Paolo Boffetta, Andrew F Olshan
Previous studies on smokeless tobacco use and head and neck cancer (HNC) have found inconsistent and often imprecise estimates, with limited control for cigarette smoking. Using pooled data from 11 US case-control studies (1981-2006) of oral, pharyngeal, and laryngeal cancers (6,772 cases and 8,375 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, we applied hierarchical logistic regression to estimate odds ratios and 95% confidence intervals for ever use, frequency of use, and duration of use of snuff and chewing tobacco separately for never and ever cigarette smokers...
October 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27742669/the-stem-cell-factor-hmga2-is-expressed-in-non-hpv-associated-head-and-neck-squamous-cell-carcinoma-and-predicts-patient-survival-of-distinct-subsites
#16
Kathrin Günther, Ronja Foraita, Juliane Friemel, Frauke Günther, Jörn Bullerdiek, Rolf Nimzyk, Dominique Nadine Markowski, Thomas Behrens, Wolfgang Ahrens
BACKGROUND: The transcription factor high-mobility AT-hook 2 (HMGA2) is involved in stem cell renewal and is expressed in many tumor tissues. Head and neck squamous cell carcinomas (HNSCC) comprise tumors of the upper aerodigestive tract and are characterized by high recurrence rates that represent a challenge to patient management. The study addresses the potential of HMGA2 as a molecular biomarker for HNSCC patient survival. METHODS: Patients with HNSCC of the larynx, pharynx, tonsils, or oral cavity were recruited in a hospital-based case-control study (n=202)...
October 14, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27735065/spironolactone-use-and-risk-of-incident-cancers-a-retrospective-matched-cohort-study
#17
Isla S Mackenzie, Steven V Morant, Li Wei, Alastair M Thompson, Thomas M MacDonald
AIMS: Spironolactone is widely used to treat heart failure, hypertension and liver disease with increased usage in recent years. Spironolactone has endocrine effects that could influence cancer risks and historical reports suggest possible links with increased risk of certain types of cancer. The aim of this study was to assess the effect of spironolactone exposure on cancer incidence. METHODS: A pharmacoepidemiological propensity score-matched cohort study was performed to assess the effect of spironolactone exposure on cancer incidence...
October 13, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27716125/dars-a-phase-iii-randomised-multicentre-study-of-dysphagia-optimised-intensity-modulated-radiotherapy-do-imrt-versus-standard-intensity-modulated-radiotherapy-s-imrt-in-head-and-neck-cancer
#18
Imran Petkar, Keith Rooney, Justin W G Roe, Joanne M Patterson, David Bernstein, Justine M Tyler, Marie A Emson, James P Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A Bhide, Kate L Newbold, Kevin J Harrington, Emma Hall, Christopher M Nutting
BACKGROUND: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27699727/a-comparison-of-large-soft-palate-defect-reconstruction-using-the-new-tunnel-structure-and-traditional-port-structure-methods
#19
Atsumori Hamahata, Takeshi Beppu, Takao Tokumaru, Takashi Yamaki, Hiroyuki Sakurai
Background For soft palate defects of more than two-thirds, we previously described the bent anterolateral thigh (ALT) method in which the pharyngeal isthmus was reconstructed as a tunnel structure. In this study, we compared the new "tunnel structure" reconstruction in our bent ALT flap method and the traditional "port structure" reconstruction. Methods From April 2010 to March 2015, 25 patients in Saitama Cancer Center (Saitama, Japan) underwent oropharyngeal tumor resection including soft palate resection...
October 3, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27699539/the-role-of-conventional-surgery-in-oropharyngeal-cancer
#20
Wojciech Golusinski
Anatomically, the oropharynx can be divided into four subsites: the soft palate, pharyngeal wall, base of tongue, and the tonsillar complex. Surgical access to these tumours is often challenging due to the anatomic localization. For this reason, such tumours were traditionally managed with open surgical techniques, usually involving a mandibulotomy, to provide better visualization and access to the oropharynx, followed by free-flap reconstruction of the oropharyngeal defect. However, the invasiveness of this approach could lead to significant morbidity, including speech, swallowing, and airway dysfunction, in addition to poor cosmetic outcomes...
2017: Recent Results in Cancer Research
keyword
keyword
69966
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"