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https://www.readbyqxmd.com/read/28994120/complications-after-endoscopic-laryngopharyngeal-surgery
#1
Yo Kishimoto, Tohru Sogami, Ryuji Uozumi, Makiko Funakoshi, Shin-Ichi Miyamoto, Morimasa Kitamura, Chiaki Suzuki, Manabu Muto, Ichiro Tateya, Koichi Omori
OBJECTIVES/HYPOTHESIS: Endoscopic laryngopharyngeal surgery (ELPS), a hybrid of head and neck surgery and gastrointestinal endoscopic treatment, has been attracting attention as a new therapeutic modality for superficial laryngopharyngeal cancers. Although this technique is less invasive than traditional open procedures, some complications including postoperative bleeding, subcutaneous emphysema, or aspiration pneumonia can occur after treatment. The purpose of this study was to investigate the complications associated with ELPS to better understand the indications for this procedure...
October 10, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28982918/differential-prognostic-value-of-metabolic-heterogeneity-of-primary-tumor-and-metastatic-lymph-nodes-in-patients-with-pharyngeal-cancer
#2
Jeon Yeob Jang, Kyoung June Pak, Keun-Ik Yi, Yong Kan Ki, Won Taek Kim, Hyojeong Kim, Young Jin Choi, Seong Jang Kim, In Joo Kim, Soo-Geun Wang, Young Mi Seol
BACKGROUND/AIM: We aimed to explore the prognostic value of metabolic heterogeneity of (18)F-FDG uptake in chemoradiotherapy-treated pharyngeal cancer patients. PATIENTS AND METHODS: This study included 52 consecutive patients with pharyngeal cancer who underwent (18)F-FDG PET/CT before definitive chemoradiotherapy. The heterogeneity factor (HF) was defined as the derivative (dV/dT) of a volume-threshold function for primary tumors and metastatic lymph nodes. The relationships between clinical parameters and HFs of primary tumors (pHF) and metastatic lymph nodes (nHF) were analyzed...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28973501/chemo-selection-with-docetaxel-cisplatin-and-5-fluorouracil-tpf-regimen-followed-by-radiation-therapy-or-surgery-for-pharyngeal-and-laryngeal-carcinoma
#3
Takuma Matoba, Kei Ijichi, Takeshi Yanagi, Kayoko Kabaya, Daisuke Kawakita, Shintaro Beppu, Junichi Torii, Shingo Murakami
Background: Induction chemotherapy for patients with head and neck cancer is widely performed, and several advantages of induction chemotherapy have been reported. However, there is currently insufficient evidence to strongly recommend induction chemotherapy. In this study, we analyzed the outcomes for patients treated with induction chemotherapy and subsequent definitive treatments. Methods: Operable patients with untreated oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma treated with induction chemotherapy were included in this retrospective study...
August 18, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28958833/cancer-risk-in-patients-with-beh%C3%A3-et-s-disease-a-nationwide-population-based-dynamic-cohort-study-from-korea
#4
Sae Jung Na, Min Ji Kang, Dong Soo Yu, Kyung-Do Han, Ji Hyun Lee, Yong Gyu Park, Young Bok Lee
BACKGROUND: Many studies have shown a link between inflammation and cancer development. However, there are few studies regarding the correlation between Behçet's disease (BD) and cancer. OBJECTIVES: To determine the overall cancer risk and risk of specific cancers in patients with BD. METHODS: BD patients (n = 14,137; mean age, 44.2 ± 12.5 years; male, 32.4%) without known previous cancer were selected from the Korean National Health Insurance Database between 2007 and 2014...
September 25, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28943045/prognostic-factors-for-tube-feeding-dependence-after-curative-chemo-radiation-in-head-and-neck-cancer-a-systematic-review-of-literature
#5
REVIEW
Kim Wopken, Hendrik P Bijl, Johannes A Langendijk
BACKGROUND: Tube feeding dependence is a commonly observed debilitating side-effect of curative (chemo-) radiation in head and neck cancer patients that severely affects quality of life. Prevention of this side-effect can be obtained using advanced radiation techniques, such as IMRT. For radiotherapy treatment plan optimization, it has become increasingly important to develop prediction models that enable clinicians to predict the risk of tube feeding dependence for individual patients...
September 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28930604/therapeutic-startegies-for-human-papillomavirus-infection-and-associated-cancers
#6
Alok Chandra Bharti, Tejveer Singh, Anjali Bhat, Deepti Pande, Mohit Jadli
Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. HPV infection-driven lesions usually take 10-20 years for malignant progression and are preceded by well-characterized pre-cancer stages...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28924068/-endovascular-treatment-for-carotid-blowout-syndrome-after-radiation-for-esophageal-cancer-a-case-report
#7
Shigefumi Takahashi, Tomohiro Kawaguchi, Kuniyasu Niizuma, Atsuhiro Nakagawa, Miki Fujimura, Takenori Ogawa, Yukio Katori, Teiji Tominaga
Here, we discuss a case of carotid blowout syndrome successfully treated with endovascular parent artery occlusion. A 71-year-old woman underwent treatment for esophageal cancer resection, followed by 50-Gy radiotherapy, 19 years prior. Due to local recurrence, she underwent 66- and 72-Gy radiation treatments at 2 and 4 years after the initial treatment, respectively. Afterward, tracheostomy and enterostomy were performed. This time, she was transported to our emergency department because of acute eruptive bleeding from the tracheal tube...
September 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28918176/ninety-day-mortality-after-radical-radiotherapy-for-head-and-neck-cancer
#8
L Dixon, K Garcez, L W Lee, A Sykes, N Slevin, D Thomson
AIMS: Treatment for head and neck cancers using definitive radiotherapy, with or without chemotherapy, is associated with significant acute toxicity. Our aim was to assess 90 day mortality after radical radiotherapy. A further aim was to identify patient, tumour or treatment factors associated with early death after treatment and whether these could be used to predict outcomes. MATERIALS AND METHODS: In total, 1116 patients with squamous cell pharyngeal and larynx cancer between January 2011 and December 2015 were included...
September 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28901495/biochanin-a-induces-apoptosis-and-suppresses-migration-in-fadu-human-pharynx-squamous-carcinoma-cells
#9
In-A Cho, Sang-Joun You, Kyeong-Rok Kang, Su-Gwan Kim, Ji-Su Oh, Jae-Seek You, Gyeong-Je Lee, Yo-Seob Seo, Do Kyung Kim, Chun Sung Kim, Sook-Young Lee, Jae-Sung Kim
The aim of the present study was to investigate biochanin-A-induced anticancer effects and their cellular signaling pathway in FaDu pharyngeal squamous carcinoma cells. Biochanin-A induced cell death through increased cytotoxicity of FaDu cells in a dose- and time-dependent manner. The number of cells with nucleus condensation and the apoptotic population were increased in the FaDu cells stimulated with biochanin-A for 24 h. Furthermore, extrinsic apoptotic factors such as FasL and their downstream target caspase-8 were increased and activated in the FaDu cells treated with biochanin-A in a dose-dependent manner...
September 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28877058/nonuniform-distribution-of-high-risk-human-papillomavirus-in-squamous-cell-carcinomas-of-the-oropharynx-rethinking-the-anatomic-boundaries-of-oral-and-oropharyngeal-carcinoma-from-an-oncologic-hpv-perspective
#10
Elise Gelwan, Ian-James Malm, Armen Khararjian, Carol Fakhry, Justin A Bishop, William H Westra
The oral cavity and oropharynx have historically been viewed as a single anatomic compartment of the head and neck. The practice of combining the oral cavity and oropharynx has recently been revised, largely owing to the observation that human papillomavirus (HPV)-related carcinogenesis has a strong predilection for the oropharynx but not the oral cavity. The purpose of this study was to determine whether HPV is evenly distributed across squamous cell carcinomas of the oropharynx including those sites that do not harbor tonsillar tissues such as the soft palate...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28874619/surgical-management-of-primary-and-recurrent-carcinoma-showing-thymous-like-elements-castle
#11
Federico Attene, Ilia Patrizia Pisano, Carlo Pala, Antonio Marrosu, Corrado Bozzo, Fabrizio Scognamillo
INTRODUCTION: Carcinoma showing thymous-like elements (CASTLE) is a rare tumor with only a few cases described in the scientific literature. The aim of the present review is to analyze the data available on the therapeutic options employed in CASTLE tumors and to outline the best surgical management to adopt. MATERIALS AND METHODS: English-language articles published from 1985 through November 2016, and related to CASTLE cases were retrieved using the Pubmed database and specific key-words...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28866829/an-investigation-of-the-prevalence-of-swallowing-difficulties-and-impact-on-quality-of-life-in-patients-with-advanced-lung-cancer
#12
Grainne C Brady, Justin W G Roe, Mary O' Brien, Annette Boaz, Clare Shaw
BACKGROUND: Dysphagia can occur in advanced lung cancer due to direct tumour invasion or nerve compression. Anti-cancer treatments and co-morbid conditions may also cause or compound dysphagic symptoms. Speech and language therapy (SLT), medical and surgical interventions are available to address dysphagic symptoms in patients with lung cancer, however, management options are not described in national guidelines. Given the potentially short prognoses for patients with lung cancer, the aim of care should be to reduce symptom burden and maximise quality of life (QOL)...
September 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28865840/efficacy-of-the-myofascial-pectoralis-major-flap-in-the-reduction-of-salivary-fistulas-after-salvage-total-laryngectomy
#13
Carlos Miguel Chiesa Estomba, Jose Angel González García, Jon Alexander Sistiaga Suarez, Izaskun Thomas Arrizabalaga, Ekhiñe Larruscain Sarasola, Xabier Altuna Mariezcurrena
INTRODUCTION: Pharyngocutaneous fistula is the most frequent complication after total laryngectomy. Its incidence varies between 9%-25% in post primary total laryngectomy patients, to 14%-57% in salvage laryngectomy post radiotherapy or post chemotherapy + radiotherapy. The pectoralis major myofascial flap (PMMF)is postulated as a useful tool to decrease the incidence of this complication. MATERIALS AND METHOD: Retrospective analysis of a group of patients treated by salvage laryngectomy, associated or not with pharyngeal closure reinforcement with PMMF...
August 30, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28841782/risk-of-malignancies-in-autoimmune-hepatitis-type-1-patients-with-a-long-term-follow-up-in-japan
#14
Teruko Arinaga-Hino, Tatsuya Ide, Ichiro Miyajima, Kei Ogata, Reiichiro Kuwahara, Keisuke Amano, Toshihiro Kawaguchi, Toru Nakamura, Takumi Kawaguchi, Hironori Koga, Koji Yonemoto, Takuji Torimura
BACKGROUNDS/AIMS: The risk of malignancies in autoimmune diseases is high and is regarded to be due to immunological abnormalities, the use of immunosuppressive agents, and/or chronic inflammation. The aim of this study was to investigate the incidence and risk of malignancies in patients with autoimmune hepatitis (AIH) type 1 in Japan. METHODS: Two hundred and fifty-six patients diagnosed with AIH were enrolled. A person-year calculation was performed for AIH patients, and the numbers of expected events were clarified using data from "The Monitoring of Cancer Incidence in Japan Project" in order to examine the standard incident rate (SIR) of each type of malignancy...
August 25, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28836534/determination-of-p16-overexpression-as-an-indicator-of-human-papillomavirus-infection-in-oral-dysplasia-and-carcinoma
#15
Adrija Pathak, Mahendra Singh, Asha Agarwal, Sonal Amit
CONTEXT: Oral and pharyngeal cancer, grouped together, is the sixth most common cancer in the world. In the past few years, human papillomavirus (HPV) infection has been suggested as a risk factor for oral cancer apart from traditional risk factors such as smoking, tobacco, and alcohol consumption. AIMS: The aim of this study was to determine HPV status of the tumors using polymerase chain reaction (HPV-DNA PCR) and p16 immunostaining and to correlate p16 overexpression as an indicator of HPV-associated oral dysplasia and carcinoma...
July 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28836005/grading-dysphagia-as-a-toxicity-of-head-and-neck-cancer-differences-in-severity-classification-based-on-mbs-digest-and-clinical-ctcae-grades
#16
Ryan P Goepfert, Jan S Lewin, Martha P Barrow, Carla L Warneke, Clifton D Fuller, Stephen Y Lai, Randal S Weber, Katherine A Hutcheson
Clinician-reported toxicity grading through common terminology criteria for adverse events (CTCAE) stages dysphagia based on symptoms, diet, and tube dependence. The new dynamic imaging grade of swallowing toxicity (DIGEST) tool offers a similarly scaled five-point ordinal summary grade of pharyngeal swallowing as determined through results of a modified barium swallow (MBS) study. This study aims to inform clinicians on the similarities and differences between dysphagia severity according to clinical CTCAE and MBS-derived DIGEST grading...
August 23, 2017: Dysphagia
https://www.readbyqxmd.com/read/28834021/multi-isocentric-4%C3%AF-volumetric-modulated-arc-therapy-approach-for-head-and-neck-cancer
#17
Vallinayagam Shanmuga Subramanian, Vellaiyan Subramani, Srinivas Chilukuri, Murugesan Kathirvel, Gandhi Arun, Shanmugam Thirumalai Swamy, Kala Subramanian, Antonella Fogliata, Luca Cozzi
OBJECTIVES: To explore the feasibility of multi-isocentric 4π volumetric-modulated arc therapy (MI4π-VMAT) for the complex targets of head and neck cancers. METHODS: Twenty-five previously treated patients of HNC underwent re-planning to improve the dose distributions with either coplanar VMAT technique (CP-VMAT) or noncoplanar MI4π-VMAT plans. The latter, involving 3-6 noncoplanar arcs and 2-3 isocenters were re-optimized using the same priorities and objectives...
August 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28816382/endoscopic-diagnosis-and-treatment-of-superficial-pharyngeal-cancer
#18
Chikatoshi Katada, Tabito Okamoto, Koichi Kano
Many cases of head and neck cancer are detected on the basis of symptoms and therefore are advanced at the time of diagnosis. Such cancers have been treated by invasive surgery and chemoradiotherapy. Recently, innovative technological developments have been made in gastrointestinal endoscopy in Japan, such as image-enhanced magnifying endoscopy, allowing superficial head and neck cancer to be detected.(1,2) Because superficial head and neck cancer previously could not be detected, diagnostic and treatment strategies have not yet been established and have become a new field of diagnosis and therapy...
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28809372/coffee-is-protective-against-oral-and-pharyngeal-cancer-a-systematic-review-and-meta-analysis
#19
J Miranda, L Monteiro, R Albuquerque, J-J Pacheco, Z Khan, J Lopez-Lopez, S Warnakulasuryia
OBJECTIVES: Coffee is one of the most popular and consumable drinks worldwide. However, there are conflicting results on the influence of this drink in oral and pharyngeal cancer risk. To clarify this, we aimed to systemically review and carry out a meta-analysis of the relevant literature on the association between coffee and oral and pharyngeal cancer. STUDY DESIGN: We carried out an electronic search of publications up to August 2016 from PubMed, National Library of Medicines Medline, Embase, Science Direct and the Cochrane Central Register...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28807066/laser-assisted-management-of-a-symptomatic-anterior-pharyngeal-diverticulum
#20
K Pujary, A C Agarwal, R Balakrishnan, A Bhandarkar
BACKGROUND: Dysphagia is a relatively common symptom following laryngectomy. An anterior pharyngeal diverticulum is a rare cause of post-laryngectomy dysphagia. However, it is often an incidental finding on rigid telescopic examination. METHODS AND RESULTS: This article describes two patients with a symptomatic anterior pharyngeal diverticulum. They were treated by transoral micro-endoscopic potassium titanyl phosphate 532 nm laser assisted resection. Both patients could take feeds orally after the procedure without any difficulty...
October 2017: Journal of Laryngology and Otology
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