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https://www.readbyqxmd.com/read/28816382/endoscopic-diagnosis-and-treatment-of-superficial-pharyngeal-cancer
#1
Chikatoshi Katada, Tabito Okamoto, Koichi Kano
Many cases of head and neck cancer are detected on the basis of symptoms and therefore are advanced at the time of diagnosis. Such cancers have been treated by invasive surgery and chemoradiotherapy. Recently, innovative technological developments have been made in gastrointestinal endoscopy in Japan, such as image-enhanced magnifying endoscopy, allowing superficial head and neck cancer to be detected.(1,2) Because superficial head and neck cancer previously could not be detected, diagnostic and treatment strategies have not yet been established and have become a new field of diagnosis and therapy...
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28809372/coffee-is-protective-against-oral-and-pharyngeal-cancer-a-systematic-review-and-meta-analysis
#2
J Miranda, L Monteiro, R Albuquerque, J-J Pacheco, Z Khan, J Lopez-Lopez, S Warnakulasuryia
OBJECTIVES: Coffee is one of the most popular and consumable drinks worldwide. However, there are conflicting results on the influence of this drink in oral and pharyngeal cancer risk. To clarify this, we aimed to systemically review and carry out a meta-analysis of the relevant literature on the association between coffee and oral and pharyngeal cancer. STUDY DESIGN: We carried out an electronic search of publications up to August 2016 from PubMed, National Library of Medicines Medline, Embase, Science Direct and the Cochrane Central Register...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28807066/laser-assisted-management-of-a-symptomatic-anterior-pharyngeal-diverticulum
#3
K Pujary, A C Agarwal, R Balakrishnan, A Bhandarkar
BACKGROUND: Dysphagia is a relatively common symptom following laryngectomy. An anterior pharyngeal diverticulum is a rare cause of post-laryngectomy dysphagia. However, it is often an incidental finding on rigid telescopic examination. METHODS AND RESULTS: This article describes two patients with a symptomatic anterior pharyngeal diverticulum. They were treated by transoral micro-endoscopic potassium titanyl phosphate 532 nm laser assisted resection. Both patients could take feeds orally after the procedure without any difficulty...
August 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28801511/paraneoplastic-mucous-membrane-pemphigoid-with-ocular-and-laryngeal-involvement
#4
Silvia Lambiel, Pavel Dulguerov, Emmanuel Laffitte, Igor Leuchter
A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. A diagnosis of anti-laminin 5 mucous membrane pemphigoid was retained, based on skin biopsy, direct immunofluorescence and immunoprecipitation...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28797451/post-operative-therapy-following-transoral-robotic-surgery-for-unknown-primary-cancers-of-the-head-and-neck
#5
Sapna A Patel, Aarthi Parvathaneni, Upendra Parvathaneni, Jeffrey J Houlton, Ron J Karni, Jay J Liao, Neal D Futran, Eduardo Méndez
OBJECTIVES: Our primary objective is to describe the post- operative management in patients with an unknown primary squamous cell carcinoma of the head and neck (HNSCC) treated with trans-oral robotic surgery (TORS). MATERIALS & METHODS: We conducted a retrospective multi-institutional case series including all patients diagnosed with an unknown primary HNSCC who underwent TORS to identify the primary site from January 1, 2010 to June 30, 2016. We excluded those with recurrent disease, ≤6months of follow up from TORS, previous history of radiation therapy (RT) to the head and neck, or evidence of primary tumor site based on previous biopsies...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28790259/-ii-organ-preserving-transoral-surgery-for-locally-advanced-laryngo-pharyngeal-cancer
#6
Shingo Tanaka, Masayuki Tomifuji, Koji Araki, Akihiro Shiotani
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28761177/analysis-of-autophagy-gene-polymorphisms-in-spanish-patients-with-head-and-neck-squamous-cell-carcinoma
#7
Javier Fernández-Mateos, Raquel Seijas-Tamayo, Juan Carlos Adansa Klain, Miguel Pastor Borgoñón, Elisabeth Pérez-Ruiz, Ricard Mesía, Elvira Del Barco, Carmen Salvador Coloma, Antonio Rueda Dominguez, Javier Caballero Daroqui, Encarnación Fernández Ruiz, Juan Jesús Cruz-Hernández, Rogelio González-Sarmiento
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28752291/composition-and-abundance-of-microbiota-in-the-pharynx-in-patients-with-laryngeal-carcinoma-and-vocal-cord-polyps
#8
Hongli Gong, Boyan Wang, Yi Shi, Yong Shi, Xiyan Xiao, Pengyu Cao, Lei Tao, Yuezhu Wang, Liang Zhou
The pharynx is an important site of microbiota colonization, but the bacterial populations at this site have been relatively unexplored by culture-independent approaches. The aim of this study was to characterize the microbiota structure of the pharynx. Pyrosequencing of 16S rRNA gene libraries was used to characterize the pharyngeal microbiota using swab samples from 68 subjects with laryngeal cancer and 28 subjects with vocal cord polyps. Overall, the major phylum was Firmicutes, with Streptococcus as the predominant genus in the pharyngeal communities...
August 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28739753/application-of-ultrasound-guided-core-needle-biopsy-in-the-diagnosis-of-t3-or-t4-stage-laryngeal-and-hypopharyngeal-cancer
#9
Yunqiang Wang, Dajian Li, Ruihua Liu, Chuanliang Jia, Aihua Jiang, Yayun Lv, Shufen Xu, Hua Zhang, Xiaoli Cao, Xicheng Song
AIM: To study the value of ultrasound-guided core needle biopsy (CNB) in the diagnosis of T3 or T4 stage laryngeal and hypopharyngeal cancer, which is difficult by routine methods. PATIENTS AND METHODS: Nineteen cases of T3 or T4 stage laryngeal or hypopharyngeal carcinoma with abnormal pharyngeal sensitivity, severe dyspnea, submucous cancer recurrence, cardiovascular and pulmonary dysfunction were reviewed retrospectively from October 2012 to October 2014 in the Yuhuangding Hospital of Qingdao University...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28724656/dietary-flavonoid-intake-reduces-the-risk-of-head-and-neck-but-not-esophageal-or-gastric-cancer-in-us-men-and-women
#10
Lucy Sun, Amy F Subar, Claire Bosire, Sanford M Dawsey, Lisa L Kahle, Thea P Zimmerman, Christian C Abnet, Ruth Heller, Barry I Graubard, Michael B Cook, Jessica L Petrick
Background: Flavonoids are bioactive polyphenolic compounds found in fruits, vegetables, and beverages of plant origin. Previous studies have shown that flavonoid intake reduces the risk of certain cancers; however, few studies to date have examined associations of flavonoids with upper gastrointestinal cancers or used prospective cohorts.Objective: Our study examined the association between intake of flavonoids (anthocyanidins, flavan-3-ols, flavanones, flavones, flavonols, and isoflavones) and risk of head and neck, esophageal, and gastric cancers...
July 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28712533/dose-volume-toxicity-modeling-for-de-intensified-chemo-radiation-therapy-for-hpv-positive-oropharynx-cancer
#11
Panayiotis Mavroidis, Alex Price, David Fried, Mark Kostich, Robert Amdur, William Mendenhall, Chihray Liu, Shiva Das, Lawrence B Marks, Bhishamjit Chera
BACKGROUND AND PURPOSE: The aim is to determine the radiobiological parameters of four popular normal tissue complication probability (NTCP) models that describe the dose-response relations of salivary glands and pharyngeal constrictors to the severity of patient reported xerostomia and dysphagia, respectively 6 and 12months post chemo-radiotherapy, furthermore, to evaluate the goodness-of-fit of the NTCP models for different combinations of glands and constrictors. MATERIAL AND METHODS: Forty-three patients were treated on a prospective multi-institutional phase II study (ClinicalTrials...
July 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28710831/dietary-fiber-intake-and-head-and-neck-cancer-risk-a-pooled-analysis-in-the-international-head-and-neck-cancer-epidemiology-consortium
#12
Daisuke Kawakita, Yuan-Chin Amy Lee, Federica Turati, Maria Parpinel, Adriano Decarli, Diego Serraino, Keitaro Matsuo, Andrew F Olshan, Jose P Zevallos, Deborah M Winn, Kirsten Moysich, Zuo-Feng Zhang, Hal Morgenstern, Fabio Levi, Karl Kelsey, Michael McClean, Cristina Bosetti, Werner Garavello, Stimson Schantz, Guo-Pei Yu, Paolo Boffetta, Shu-Chun Chuang, Mia Hashibe, Monica Ferraroni, Carlo La Vecchia, Valeria Edefonti
The possible role of dietary fiber in the etiology of head neck cancers (HNCs) is unclear. We used individual-level pooled data from ten case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders...
July 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28705771/different-frequencies-of-porphyromonas-gingivalis-infection-in-cancers-of-the-upper-digestive-tract
#13
Xiang Yuan, Yiwen Liu, Jinyu Kong, Bianli Gu, Yijun Qi, Xinshuai Wang, Man Sun, Pan Chen, Wei Sun, Huizhi Wang, Fuyou Zhou, Shegan Gao
The high incidence rate of multiple carcinomas in the upper digestive tract is often explained in terms of involvement of the same underlying risk factors. It has been reported that the oral bacterium Streptococcus anginosus is associated with esophageal, gastric, and pharyngeal cancers. We previously reported occurrence of Porphyromonas gingivalis (P. gingivalis) DNA in esophagus cancer. In this study, the presence of P. gingivalis in specimens of various types of cancer from the upper digestive tract was investigated...
July 11, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28691045/pharyngocutaneous-fistula-as-an-alternative-access-route-for-inserting-a-percutaneous-endoscopic-gastrostomy-tube-in-head-and-neck-cancer-patients
#14
Louise Deluiz Verdolin Di Palma, Gustavo Francisco de Souza E Mello, Cindy Lis Granados, Ricardo Dardengo Glória, Caroline Sauter Dalbem, Rolantre Lopes da Cruz, Ana Carolina Maron Ayres, Renata Sofia Camara Lisboa, Alexandre Dias Pelosi, Maria Aparecida Ferreira, Gilberto Reynaldo Mansur, Simone Guaraldi da Silva, Theresa Christina Damian Ribeiro, Fernando Luiz Dias
BACKGROUND AND STUDY AIMS:  Performing a percutaneous endoscopic gastrostomy (PEG) in head and neck cancer (HNC) patients can be challenging because of the presence of trismus, pharyngeal obstruction by tumor, and pharyngoesophageal strictures or fistula. Pharyngocutaneous fistula (PCF) is a major postoperative concern in patients submitted to total laryngectomy (TL). In the medical literature to date, the cervical fistula has been used as an access to PEG in only four reports. The aim of this study was to evaluate the safety of cervical fistula for insertion of a PEG tube...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28688679/long-term-toxicities-in-10-year-survivors-of-radiation-treatment-for-head-and-neck-cancer
#15
Yanqun Dong, John A Ridge, Tianyu Li, Miriam N Lango, Thomas M Churilla, Jessica R Bauman, Thomas J Galloway
OBJECTIVES: To characterize the recognized but poorly understood long-term toxicities of radiation therapy (RT) for head and neck cancer (HNC). MATERIALS AND METHODS: We retrospectively evaluated patients treated with curative-intent RT for HNC between 1990 and 2005 at a single institution with systematic multidisciplinary follow-up ≥10years. Long-term toxicities of the upper aerodigestive tract were recorded and assigned to two broad categories: pharyngeal-laryngeal and oral cavity toxicity...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28670280/trends-and-patterns-of-disparities-in-oral-cavity-and-pharyngeal-cancer-in-serbia-prevalence-and-economic-consequences-in-a-transitional-country
#16
Gordana Djordjevic, Aleksandar Dagovic, Vladimir Ristic, Tatjana Kanjevac, Denis Brajkovic, Milica Popovic
No abstract text is available yet for this article.
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28669164/application-of-the-weibull-distribution-with-a-non-constant-shape-parameter-for-identifying-risk-factors-in-pharyngeal-cancer-patients
#17
Haleh Aghamolaey, Ahmad Reza Baghestani, Farid Zayeri
Background: In its standard form, the parametric survival model assumes that the shape parameter is constant and the scaling parameter is not. This article focuses on how a model with a non-constant shape parameter could make differences in oncology studies and lead to more precise results. Materials and Methods: Online data for part of a large clinical trial conducted by the Radiation Oncology Group in the United States available online on UMass Amherst`s website were employed. The full study included patients with squamous cell carcinoma from fifteen sites in the mouth and throat, although only data on three sites in the oropharynx reported by the six largest institutions were considered here...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28662244/association-of-insurance-and-community-level-socioeconomic-status-with-treatment-and-outcome-of-squamous-cell-carcinoma-of-the-pharynx
#18
Jacob Y Shin, Ja Kyoung Yoon, Aaron K Shin, Philip Blumenfeld, Miranda Mai, Aidnag Z Diaz
Importance: Community-level socioeconomic status, particularly insurance status, is increasingly becoming important as a possible determinant in patient outcomes. Objective: To determine the association of insurance and community-level socioeconomic status with outcome for patients with pharyngeal squamous cell carcinoma (SCC). Design, Setting, and Participants: This study extracted data from more than 1500 Commission on Cancer-accredited facilities collected in the National Cancer Database...
June 29, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28661556/synopsis-of-transoral-endoscopic-laryngopharyngeal-surgery-for-superficial-pharyngeal-cancers
#19
Akihito Watanabe, Masanobu Taniguchi, Yuki Kimura, Masao Hosokawa, Suguru Ito, Shinji Tsukamoto, Shigeyuki Sasaki
BACKGROUND: Endoscopic laryngopharyngeal surgery (ELPS) was developed for superficial pharyngeal cancers in Japan. In this study, we present our results of ELPS for superficial pharyngeal cancers. METHODS: From November 2009 to December 2015, 258 patients with superficial pharyngeal cancers underwent ELPS. Results, including survival rates, postoperative complications, and vocal function, are reviewed. RESULTS: The median follow-up period of 258 patients was 31 months...
June 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28651556/clinical-outcomes-of-transoral-videolaryngoscopic-surgery-for-hypopharyngeal-and-supraglottic-cancer
#20
Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita, Kaoru Ogawa
BACKGROUND: Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment outcomes of TOVS remain to be validated. METHODS: Under a straight broad intraluminal view provided by combined use of a distending laryngoscope and a videolaryngoscope, we performed en bloc tumor resection via direct bimanual handling of the ready-made straight-form surgical instruments and devices...
June 26, 2017: BMC Cancer
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