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https://www.readbyqxmd.com/read/29909891/prevalence-prognosis-and-treatment-implications-of-retropharyngeal-nodes-in-unknown-primary-head-and-neck-carcinoma
#1
Gilad Horowitz, Ali Hosni, Eugene Yu, Wei Xu, Lin Lu, Michael Au, Peter R Dixon, Dale Brown, Douglas B Chepeha, Ralph W Gilbert, David P Goldstein, Patrick J Gullane, Jonathan C Irish, Andrew Bayley, John Cho, Meredith Giuliani, Shao Hui Huang, Andrew Hope, John Kim, Brian O'Sullivan, Jolie Ringash, John Waldron, Ilan Weinreb, Bayardo Perez-Ordonez, Scott V Bratman, John R de Almeida
OBJECTIVE: (1) To estimate the prevalence of radiographically positive Retro-Pharyngeal Lymph Nodes (RPLN) in unknown primary carcinoma of the head and neck and (2) to determine the prognostic implications of radiographically positive RPLN and other radiographic features (3) to identify patients at low risk for retropharyngeal metastasis. MATERIALS AND METHODS: The medical records of all 68 eligible patients treated at the Princess Margaret Cancer Centre between 2000 and 2014 were retrospectively reviewed for demographic, clinical, pathologic, and radiologic data...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29904382/retinoic-acid-receptor-related-orphan-receptors-critical-roles-in-tumorigenesis
#2
REVIEW
Jinshuo Fan, Zhilei Lv, Guanghai Yang, Ting Ting Liao, Juanjuan Xu, Feng Wu, Qi Huang, Mengfei Guo, Guorong Hu, Mei Zhou, Limin Duan, Shuqing Liu, Yang Jin
Retinoic acid receptor-related orphan receptors (RORs) include RORα (NR1F1), RORβ (NR1F2), and RORγ (NR1F3). These receptors are reported to activate transcription through ligand-dependent interactions with co-regulators and are involved in the development of secondary lymphoid tissues, autoimmune diseases, inflammatory diseases, the circadian rhythm, and metabolism homeostasis. Researches on RORs contributing to cancer-related processes have been growing, and they provide evidence that RORs are likely to be considered as potential therapeutic targets in many cancers...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29898433/electrochemotherapy-with-cisplatin-or-bleomycin-in-head-and-neck-squamous-cell-carcinoma-improved-effectiveness-of-cisplatin-in-hpv-positive-tumors
#3
Ajda Prevc, Martina Niksic Zakelj, Simona Kranjc, Maja Cemazar, Janez Scancar, Tina Kosjek, Primoz Strojan, Gregor Sersa
Human papillomavirus (HPV) is an important etiological factor in head and neck squamous cell carcinomas (SCCs). Standard treatment of HPV-positive tumors with platinum-based radio(chemo)therapy results in a better outcome than in HPV-negative tumors. Electrochemotherapy is becoming an increasingly recognized mode of treatment in different cancers; thus, its use in the management of head and neck SCC is of considerable interest. However, response to electrochemotherapy according to HPV status of the tumors has not been evaluated yet...
June 6, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29884412/comparative-genomic-analysis-of-oral-versus-laryngeal-and-pharyngeal-cancer
#4
David M Vossen, Caroline V M Verhagen, Marcel Verheij, Lodewyk F A Wessels, Conchita Vens, Michiel W M van den Brekel
OBJECTIVE: Locally advanced oral squamous cell carcinoma (OSCC) shows lower locoregional control and disease specific survival rates than laryngeal and pharyngeal squamous cell carcinoma (L/P-SCC) after definitive chemoradiotherapy treatment. Despite clinical factors, this can point towards a different tumor biology that could impact chemoradiotherapy response rates. This prompted us to compare the mutational profiles of OSCC with L/P-SCC. METHODS: We performed target capture DNA sequencing on 111 HPV-negative HNSCC samples (NKI dataset), 55 oral and 56 laryngeal/pharyngeal, and identified somatic point mutations and copy number aberrations...
June 2018: Oral Oncology
https://www.readbyqxmd.com/read/29879250/frequency-of-treatment-switching-for-spironolactone-compared-to-oral-tetracycline-class-antibiotics-for-women-with-acne-a-retrospective-cohort-study-2010-2016
#5
John S Barbieri, Juliana K Choi, Nandita Mitra, David J Margolis
BACKGROUND: Long-term oral antibiotic use in acne may be associated with a variety of adverse effects including antibiotic resistance, pharyngitis, inflammatory bowel disease, and breast and colon cancer. Spironolactone may represent an effective and safe alternative to oral antibiotics for women with moderate to severe acne, however comparative studies are lacking. METHODS: Using the OptumInsight™ Clinformatics™ DataMart, we conducted a retrospective analysis of the frequency of switching to a different systemic agent within the first year of therapy among women with acne who were started on either spironolactone or an oral tetracycline-class antibiotic between 2010-2016, after controlling for age, topical retinoid, and oral contraceptive use...
June 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29866601/a-phase-ii-randomized-trial-comparing-neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiotherapy-versus-concurrent-chemoradiotherapy-alone-in-advanced-squamous-cell-carcinoma-of-the-pharynx-or-larynx
#6
Pei-Wei Huang, Chien-Yu Lin, Chia-Hsun Hsieh, Cheng-Lung Hsu, Kang-Hsing Fan, Shiang-Fu Huang, Chun-Ta Liao, Shu-Kung Ng, Tzu-Chen Yen, Joseph Tung-Chieh Chang, Hung-Ming Wang
BACKGROUND: To clarify the effect of induction chemotherapy (ICT) in patients with advanced pharyngeal and laryngeal squamous cell carcinoma (PLSCC) treated with concurrent chemoradiotherapy (CCRT). METHODS: Patients with treatment-naïve nonmetastatic advanced PLSCC were stratified according to disease stage (III or IV) and resectability before being randomized to either a ICT/CCRT or CCRT arm. A cisplatin/tegafur-uracil/leucovorin regimen was administered during ICT and CCRT...
April 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29808625/pathologic-study-of-tumour-extension-for-clinically-localized-unilateral-nasopharyngeal-carcinoma-should-the-contralateral-side-be-included-in-the-clinical-target-volume
#7
An-Chuan Li, Ying-Ying Zhang, Chi Zhang, De-Sheng Wang, Ben-Hua Xu
INTRODUCTION: The clinical target volume (CTV) delineation is crucial for tumour control and normal tissue protection. This study investigated the contralateral extension of nasopharyngeal carcinoma (NPC) in patients with a clinically diagnosed unilateral tumour to pursue the possibility of CTV reduction. METHODS: Twenty NPC patients with localized tumours confined to only one side of the nasopharynx as shown by magnetic resonance imaging and fibreoptic endoscopy were selected for biopsy...
May 28, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29800022/identification-of-phenotypic-patterns-of-dysphagia-a-proof-of-concept-study
#8
Kendrea L Focht Garand, Kent E Armeson, Elizabeth G Hill, Bonnie Martin-Harris
Purpose: The purpose of the current project was to explore the feasibility for subtyping dysphagia traits or patterns of scores in a subset of data from the Modified Barium Swallow Impairment Profile global registry in patients referred to videofluoroscopic swallowing studies across 5 common medical categories: (a) cardiothoracic, (b) gastroenterology, (c) head and neck cancer, (d) neurology, and (e) pulmonary. Method: Videofluoroscopic swallowing study imaging and Modified Barium Swallow Impairment Profile metrics were used to evaluate 235 patients with dysphagia grouped into 1 of the 5 categories...
May 15, 2018: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29798390/-platysma-myocutaneous-flaps-in-reconstruction-of-defects-caused-by-hypopharyngeal-cancer-resection
#9
Z F Sun, G L Wang, Y Y Liu, J Ding, D Luo, P Dong
Objective: To study the method and feasibility in reconstruction of platysma myocutaneous flap of defects caused by hypopharyngeal cancer resection. Method: Twelve cases underwent reconstruction with the platysma myocutaneous flap of hypopharyngeal soft defect were investigated. All cases received 2 times preoperative induction chemotherapy followed by hypopharyngeal cancer resection with laryngeal function preservation and the neck lymph node dissection. Platysma myocutaneous flap was used to repair the hypopharyngeal soft tissue defect...
December 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29797467/the-critical-importance-of-pharyngeal-contractile-forces-on-the-validity-of-intrabolus-pressure-as-a-predictor-of-impaired-pharyngo-esophageal-junction-compliance
#10
M M Szczesniak, P I Wu, J Maclean, T I Omari, I J Cook
INTRODUCTION: Restrictive defects of the pharyngo-esophageal junction (PEJ) are common in both structural and neurological disorders and are amenable to therapies aiming to reduce outflow resistance. Intrabolus pressure (IBP) acquired with high-resolution manometry and impedance (HRMI) is an indicator of resistance and a marker of reduced PEJ compliance. Constraints and limitations of IBP as well as the optimal IBP parameter remain undefined. AIMS: To determine: (i) the impact of peak pharyngeal pressure (PeakP) on the diagnostic accuracy of IBP for the detection of a restrictive defect at the PEJ and (ii) the optimal IBP parameter for this purpose...
May 24, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29766739/lingual-thyroid-carcinoma-a-case-report-and-review-of-surgical-approaches-in-the-literature
#11
William Stokes, Eric Interval, Rusha Patel
INTRODUCTION: Lingual thyroid cancer is a rare entity with a paucity of literature guiding methods of surgical treatment. Its location presents anatomic challenges with access and excision. OBJECTIVE: We present a case of T4aN1b classical variant papillary thyroid carcinoma of the lingual thyroid that was removed without pharyngeal entry. We also present a review of the literature of this rare entity and propose a treatment algorithm to provide safe and oncologic outcomes...
May 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29764017/-significance-of-retropharyngeal-node-dissection-in-treatment-of-hypopharyngeal-carcinoma
#12
Z H Lyu, W Xu, N Sa, J K Ma, J J Tian, S H Feng, H Y Cao
Objective: investigate the incidence of retropharyngeal lymph node (RPLN) metastasis and the risk factors for RPLN metastasis in hypopharyngeal cancer, and the relationship of planned dissection of the RPLN with the survival and tumor control rates in patients with hypopharyngeal cancer. Methods: A total of 203 patients with hypopharyngeal squamous cell carcinoma who underwent radical surgery as initial treatment from February 2011 to July 2015 were analyzed retrospectively. There were 167 cases of pyriform sinus carcinoma, 23 cases of posterior pharyngeal wall carcinoma, and 13 cases of postcricoid carcinoma...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29764015/-treatment-and-prognosis-of-264-patients-with-hypopharyngeal-carcinoma
#13
W Xu, Z H Lyu, N Sa, J K Ma, J J Tian, S H Feng, P Cui, H Y Cao
Objective: To investigate the key factors influencing the prognosis of hypopharyngeal carcinoma and the therapeutic methods improving the efficacy of treatments for hypopharyngeal carcinoma. Methods: Two hundred and sixty-four cases of hypopharyngeal squamous cell carcinoma treated from May 2010 to May 2015 were analyzed retrospectively. There were 211 cases of pyriform sinus carcinoma, 37 cases of posterior pharyngeal wall carcinoma, and 16 cases of postcricoid carcinoma. According to UICC 2002 criteria, 2 cases were for stage Ⅰ, 14 for stage Ⅱ, 32 for stage Ⅲ and 216 for stage Ⅳ...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29761303/racial-differences-in-the-relationship-between-tobacco-alcohol-and-the-risk-of-head-and-neck-cancer-pooled-analysis-of-us-studies-in-the-inhance-consortium
#14
Kristin J Voltzke, Yuan-Chin Amy Lee, Zuo-Feng Zhang, Jose P Zevallos, Guo-Pei Yu, Deborah M Winn, Thomas L Vaughan, Erich M Sturgis, Elaine Smith, Stephen M Schwartz, Stimson Schantz, Joshua Muscat, Hal Morgenstern, Michael McClean, Guojun Li, Philip Lazarus, Karl Kelsey, Maura Gillison, Chu Chen, Paolo Boffetta, Mia Hashibe, Andrew F Olshan
There have been few published studies on differences between Blacks and Whites in the estimated effects of alcohol and tobacco use on the incidence of head and neck cancer (HNC) in the United States. Previous studies have been limited by small numbers of Blacks. Using pooled data from 13 US case-control studies of oral, pharyngeal, and laryngeal cancers in the International Head and Neck Cancer Epidemiology Consortium, this study comprised a large number of Black HNC cases (n = 975). Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for several tobacco and alcohol consumption characteristics...
May 14, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29756389/pretreatment-risk-stratification-of-feeding-tube-use-in-patients-treated-with-intensity-modulated-radiotherapy-for-head-and-neck-cancer
#15
Nigel J Anderson, James E Jackson, Jennifer G Smith, Morikatsu Wada, Michal Schneider, Michael Poulsen, Maureen Rolfo, Maziar Fahandej, Hui Gan, Daryl Lim Joon, Vincent Khoo
BACKGROUND: The purpose of this study was to establish a risk stratification model for feeding tube use in patients who undergo intensity-modulated radiotherapy (IMRT) for head and neck cancers. METHODS: One hundred thirty-nine patients treated with definitive IMRT (+/- concurrent chemotherapy) for head and neck mucosal cancers were included in this study. Patients were recommended a prophylactic feeding tube and followed up by a dietician for at least 8 weeks postradiotherapy (post-RT)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29753688/citrus-fruits-intake-and-oral-cancer-risk-a-systematic-review-and-meta-analysis
#16
REVIEW
Santa Cirmi, Michele Navarra, Jayne V Woodside, Marie M Cantwell
OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm. STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
May 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29747255/-endoscopic-screening-for-upper-gastrointestinal-second-primary-malignancies-in-patients-with-hypopharyngeal-squamous-cell-carcinoma
#17
J J Tian, W Xu, Z H Lyu, J K Ma, P Cui, N Sa, H Y Cao
Objective: To evaluate the usefullness of flexible esophagoscopy and chromoendoscopy with Lugol's solution in the detection of synchronous esophageal neoplasm in patients with hypopharyngeal squamous cell carcinoma (HSCC). Methods: A retrospective review of 96 cases with HSCC that received surgical treatment from March 2016 to March 2017 was accomplished. In these patients, the site of origin were pyriform sinus ( n =75), posterior pharyngeal wall ( n =11) and postcricoid ( n =10). Esophagoscopy was prospectively performed on all patients before treatment for HSCC...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29731889/swallowing-disorder-following-salvage-total-pharyngo-laryngo-esophagectomy-with-free-jejunum-reconstruction
#18
Takashi Maruo, Minoru Sakuraba, Takeshi Shinozaki, Toshifumi Tomioka, Wataru Okano, Satoko Arahira, Yoshie Iino, Ryuichi Hayashi
For recurrent cases or residual cases following concomitant chemo-radiation therapy (CCRT), salvage surgery is a frequently used treatment options. A swallowing disorder is one of the major complications of CCRT. The purpose of the present study was to evaluate the effect of CCRT on swallowing function in patients who underwent salvage total pharyngo-laryngo-esophagectomy (TPLE), and to evaluate the importance of pharyngeal constriction in patients who underwent TPLE. Between 2008 January and 2014 May, 54 patients were treated with salvage TPLE following CCRT or TPLE at the National Cancer Center Hospital East, Chiba, Japan and were included in the present study...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29721187/total-lesion-glycolysis-on-fdg-pet-ct-before-salvage-surgery-predicts-survival-in-laryngeal-or-pharyngeal-cancer
#19
Hidenori Suzuki, Tsuneo Tamaki, Masami Nishio, Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Yusuke Koide, Yasuhisa Hasegawa
We investigated whether 18F-fluorodeoxyglucose uptake parameters using positron emission tomography combined with computed tomography predicts several survival outcomes, including lung metastasis-free survival, in patients with laryngeal or pharyngeal cancer who underwent salvage surgery. The maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were calculated as 18F-fluorodeoxyglucose uptake parameters in 51 patients with laryngeal or pharyngeal cancer before salvage surgery...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713897/coordination-of-pharyngeal-and-laryngeal-swallowing-events-during-single-liquid-swallows-after-oral-endotracheal-intubation-for-patients-with-acute-respiratory-distress-syndrome
#20
Martin B Brodsky, Ishani De, Kalyan Chilukuri, Minxuan Huang, Jeffrey B Palmer, Dale M Needham
To evaluate timing and duration differences in airway protection and esophageal opening after oral intubation and mechanical ventilation for acute respiratory distress syndrome (ARDS) survivors versus age-matched healthy volunteers. Orally intubated adult (≥ 18 years old) patients receiving mechanical ventilation for ARDS were evaluated for swallowing impairments via a videofluoroscopic swallow study (VFSS) during usual care. Exclusion criteria were tracheostomy, neurological impairment, and head and neck cancer...
April 30, 2018: Dysphagia
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