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https://www.readbyqxmd.com/read/29662231/processed-meat-and-risk-of-selected-digestive-tract-and-laryngeal-cancers
#1
Valentina Rosato, Daisuke Kawakita, Eva Negri, Diego Serraino, Werner Garavello, Maurizio Montella, Adriano Decarli, Carlo La Vecchia, Monica Ferraroni
BACKGROUND/OBJECTIVES: To assess the association between processed meat and the risk of selected digestive tract and laryngeal cancers. SUBJECTS/METHODS: We conducted a series of case-control studies between 1985 and 2007 in Italy. The studies included a total of 1475 cases of cancer of the oral cavity and pharynx, 1077 of the larynx, 716 of the esophagus, 999 of the stomach, 684 of the liver, 159 of the biliary tract, 688 of the pancreas, and a total of 9720 controls...
April 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29616118/adenosine-induces-intrinsic-apoptosis-via-the-pi3k-akt-mtor-signaling-pathway-in-human-pharyngeal-squamous-carcinoma-fadu-cells
#2
Mi Suk Choi, Sung-Min Moon, Seul Ah Lee, Bo-Ram Park, Jae-Sung Kim, Do Kyung Kim, Yong Hwan Kim, Chun Sung Kim
Adenosine has been identified to occur abundantly intra-and extracellularly, and to exert diverse biological functions, including the suppression of cell proliferation and the induction of apoptosis. Adenosine has been reported to induce apoptosis in several cancer cell lines; however, to the best of our knowledge, the effect of adenosine on head and neck cancer cells has not been investigated. Therefore, the purpose of the present study was to evaluate whether adenosine exerts any anticancer effect via induction of apoptosis in human pharyngeal squamous carcinoma FaDu cells...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29611769/predictors-of-complications-in-patients-receiving-head-and-neck-free-flap-reconstructive-procedures
#3
Antoine Eskander, Stephen Kang, Ben Tweel, Jigar Sitapara, Matthew Old, Enver Ozer, Amit Agrawal, Ricardo Carrau, James W Rocco, Theodoros N Teknos
Objective To (1) determine the overall complication rate, wound healing, and wound infection complications and (2) identify preoperative, intraoperative, and postoperative predictors of these complications. Study Design Case series with chart review. Setting Tertiary academic cancer hospital. Subjects and Methods All head and neck free flap patients at The Ohio State University (2006-2012) were assessed. Multivariable logistic regression assessed the impact of patient factors, flap and wound factors, and intraoperative factors on the aforementioned quality metric outcomes...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29610959/poor-oral-intake-causes-enteral-nutrition-dependency-after-concomitant-chemoradiotherapy-for-pharyngeal-cancers
#4
Ryo Ishii, Kengo Kato, Takenori Ogawa, Takeshi Sato, Ayako Nakanome, Akira Ohkoshi, Ai Kawamoto-Hirano, Masayuki Shirakura, Hiroshi Hidaka, Yukio Katori
PURPOSE: To identify precipitating factors responsible for enteral nutrition (EN) dependency after concomitant chemoradiotherapy (CCRT) of head and neck cancers and to examine their statistical correlations. METHODS: Factors related to feeding condition, nutritional status, disease, and treatment of 26 oropharyngeal and hypopharyngeal cancer patients who received definitive CCRT were retrospectively investigated by examining their medical records. The days of no oral intake (NOI) during hospitalization and the months using enteral nutrition after CCRT were counted as representing the feeding condition, and the changes in body weight (BW) were examined as reflecting nutritional status...
April 2, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29594240/skull-base-or-cervical-vertebral-osteomyelitis-following-chemoradiotherapy-for-pharyngeal-carcinoma-a-serious-but-treatable-complication
#5
Nafisha Lalani, Shao Hui Huang, Coleman Rotstein, Eugene Yu, Jonathan Irish, Brian O'Sullivan
Osteomyelitis, infection of the bone and marrow, following high dose (chemo-)radiotherapy for head and neck cancer is uncommon and rarely seen in the cervical spine or temporal bone. Due to its proximity to critical structures, osteomyelitis in the latter regions could carry potentially important consequences. Furthermore, involvement near the skull base (e.g. temporal bone and high cervical vertebrae) presents unique challenges in diagnosis (especially in the differentiation from disease recurrence) and treatment, making early detection and timely intervention critical...
January 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29575160/association-of-serious-infections-with-pemphigus-and-pemphigoid-analysis-of-the-nationwide-inpatient-sample
#6
Ziyou Ren, Shanthi Narla, Derek Y Hsu, Jonathan I Silverberg
BACKGROUND: Pemphigus and pemphigoid are blistering disorders associated with barrier disruption, immune dysregulation and use of immunosuppressing systemic therapy, which may predispose toward serious infections. OBJECTIVES: To determine whether pemphigus and pemphigoid are associated with increased likelihood of serious infections, and the impact of such infections on mortality and cost of care. METHODS: We analyzed data from the 2002-2012 National Inpatient Sample, including a representative 20% sample of all hospitalizations in the US (total n=72,108,077 adults)...
March 25, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29572573/longitudinal-evaluation-of-swallowing-with-videofluoroscopy-in-patients-with-locally-advanced-head-and-neck-cancer-after-chemoradiation
#7
Ekaterini Xinou, Ioannis Chryssogonidis, Anna Kalogera-Fountzila, Dimitra Panagiotopoulou-Mpoukla, Athanasia Printza
The aim of this study was to investigate the prevalence, severity, and pattern of evolution of swallowing impairments encountered in head and neck cancer (HNC) patients before and after chemoradiation (CRT) with videofluoroscopy of swallowing study (VFSS), using the modified barium swallow impairment profile (MBSImP) protocol and scoring system, and to determine the appropriate time points in which these patients should undergo VFSS post-CRT. A prospective cohort of 69 patients with locally advanced HNC underwent VFSS with the MBSImP protocol at 5 evaluation points: pre-CRT, and 1, 3, 6, and 12 months post-CRT...
March 23, 2018: Dysphagia
https://www.readbyqxmd.com/read/29565652/effectiveness-of-tomotherapy-vs-linear-sccelerator-image-guided-intensity-modulated-radiotherapy-for-localized-pharyngeal-cancer-treated-with-definitive-concurrent-chemoradiotherapy-a-taiwanese-population-based-propensity-score-matched-analysis
#8
Yao-Ching Wang, Chia-Chin Li, Chun-Ru Chien
OBJECTIVE: This study used a population-based propensity score (PS)-matched analysis to compare the effectiveness of tomotherapy-based image-guided intensity-modulated radiotherapy (referred to as T-IMRT) with that of linear accelerator based (referred to as L-IMRT) for clinically localized pharyngeal cancer (LPC, divided into nasopharyngeal cancer and non-nasopharyngeal cancer) with definitive concurrent chemoradiotherapy (CCRT). METHODS: Eligible LPC patients diagnosed between 2007 and 2014 were identified among all citizens in Taiwan from the Health and Welfare Data Science Center database...
March 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29523427/physiologic-distribution-of-psma-ligand-in-salivary-glands-and-seromucous-glands-of-the-head-and-neck-on-pet-ct
#9
Thomas J W Klein Nulent, Matthijs H Valstar, Bart de Keizer, Stefan M Willems, Laura A Smit, Abrahim Al-Mamgani, Ludwig E Smeele, Robert J J van Es, Remco de Bree, Wouter V Vogel
OBJECTIVES: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is used for detection and (re)staging of prostate cancer. However, healthy salivary, seromucous, and lacrimal glands also have high PSMA-ligand uptake. This study aimed to describe physiologic PSMA-ligand uptake distribution characteristics in the head and neck to aid in PSMA PET/CT interpretation and to identify possible new clinical applications for PSMA-ligand imaging. STUDY DESIGN: Thirty consecutive patients who underwent PSMA PET/CT for prostate cancer were evaluated...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29476296/elucidation-of-the-anatomical-mechanism-of-nodal-skip-metastasis-in-superficial-thoracic-esophageal-squamous-cell-carcinoma
#10
Yuji Kumakura, Takehiko Yokobori, Tomonori Yoshida, Keigo Hara, Makoto Sakai, Makoto Sohda, Tatsuya Miyazaki, Hideaki Yokoo, Tadashi Handa, Tetsunari Oyama, Hiroshi Yorifuji, Hiroyuki Kuwano
BACKGROUND: Lymph node metastasis (LNM) is a standard mechanism of cancer progression in esophageal squamous cell carcinoma (ESCC). We aimed to clarify the anatomical mechanism of skip nodal metastasis to mediastinal zones by analyzing the relationship between LNM to sentinel zones and lymphatic vessel counts in the muscle layer adjacent to the outer esophagus. METHODS: We examined the surgical records of 287 patients with ESCC who underwent potentially curative surgery (three-field lymphadenectomy) and whole esophagi, including pharynges and stomachs from 10 cadavers, to determine the number of lymphatic vessels in the intra-outer longitudinal muscle layer adjacent to the outer esophagus of the cervical (Ce), upper thoracic, middle thoracic (Mt), lower thoracic (Lt), and abdominal esophagi (Ae)...
February 23, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29467876/comparison-of-the-safety-of-the-application-of-painless-gastroscopy-and-ordinary-gastroscopy-in-chronic-hypertension-patients-combined-with-early-gastric-cancer
#11
Fangli Men, Lianmin Wei, Bing Liu, Fengting Wu, Jingyu Liu, Ni Guo, Qing Niu
The aim of the present study was to compare the safety of the application of painless gastroscopy and ordinary gastroscopy for chronic hypertension patients combined with early gastric cancer. A total of 123 patients with early gastric cancer were selected at the Dongying People's Hospital from June, 2014 to August, 2016. The patients were randomly divided into the painless (n=63) and ordinary (n=60) gastroscopy groups. Proper pretreatment was performed according to whether anesthesia was performed or not. Arterial pressure, heart rate, and blood oxygen saturation were detected and compared before anesthesia, when gastroscope passed through the esophageal entrance plane, and after recovery from anesthesia...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29428959/feasibility-of-salvage-selective-neck-dissection-after-primary-irradiation-of-pharyngeal-and-laryngeal-carcinoma
#12
Norhafiza Mat Lazim, Kahairi Abdullah, Baris Karakullukcu, Ing Bing Tan
INTRODUCTION: The concept of neck dissection (ND) in the management armamentarium of head and neck squamous cell carcinoma has evolved throughout the years. Nowadays, ND becomes more functional. METHODOLOGY: A retrospective study of 865 patients was performed at Netherlands Cancer Institute-Antoni Van Leeuwenhoek Hospital to investigate the feasibility of selective ND (SND). All patients with squamous cell carcinoma of the pharynx and larynx who received primary radiation and underwent salvage ND were included in the study...
February 9, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29423747/relationship-between-swallowing-related-quality-of-life-and-fiberoptic-endoscopic-evaluation-of-swallowing-in-patients-who-underwent-open-partial-horizontal-laryngectomy
#13
Nicole Pizzorni, Antonio Schindler, Marco Fantini, Andy Bertolin, Giuseppe Rizzotto, Federico Ambrogi, Giovanni Succo, Erika Crosetti
BACKGROUND: Several studies have previously analyzed the relationship between QOL and signs of dysphagia in patients treated for head and neck cancer and have reported heterogeneous findings. To the best of our knowledge, no study has previously investigated this relationship among patients who underwent open partial horizontal laryngectomy (OPHL). The aim of the study is to determine if patient-reported swallowing-related QOL can discriminate between safe and unsafe swallowing in OPHL patients...
February 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29412371/trend-of-oral-and-pharyngeal-cancer-mortality-in-brazil-in-the-period-of-2002-to-2013
#14
Lillia Magali Estrada Perea, Marco Aurélio Peres, Antonio Fernando Boing, José Leopoldo Ferreira Antunes
OBJECTIVE: To analyze the trend of oral and pharyngeal cancer mortality rates in the period of 2002 to 2013 in Brazil according to sex, anatomical site, and macroregion of the country. METHODS: The mortality data were obtained from the Mortality Information System and the population data were obtained from the Brazilian Institute of Geography and Statistics. The trend of the rates standardized by sex and age was calculated using the Prais-Winsten estimation, and we obtained the annual percentage change and the respective 95% confidence intervals, analyzed according to sex, macroregion, and anatomical site...
February 5, 2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29392234/effect-of-bupivacaine-lozenges-on-oral-mucositis-pain-a-randomized-controlled-multicenter-phase-ii-study
#15
Stine Mogensen, Charlotte Treldal, Claus A Kristensen, Jens Bentzen, Louise Lawson-Smith, Janne Petersen, Ove Andersen
Introduction: A nonblinded parallel-group randomized controlled study investigated the efficacy and tolerability of repeated administration of a bupivacaine lozenge (25 mg) as pain management for oral mucositis pain in head and neck cancer patients as add-on to standard systemic pain management. Objective: The primary end point was the difference between the intervention group (Lozenge group) and the Control group in daily mean pain scores in the oral cavity or pharynx (whichever was higher)...
September 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29380039/olfactory-and-gustatory-functions-after-free-flap-reconstruction-and-radiotherapy-for-oral-and-pharyngeal-cancer-a-prospective-follow-up-study
#16
Markus Lilja, Mari Markkanen-Leppänen, Sanna Viitasalo, Kauko Saarilahti, Andrew Lindford, Patrik Lassus, Antti Mäkitie
BACKGROUND: The senses of smell and taste can be adversely affected by both tumour- and treatment-related factors amongst head and neck cancer patients. The consequences may negatively impact nutritional status as well as quality of life in this patient population. PATIENTS AND METHODS: This prospective longitudinal follow-up study is consisted of 44 patients treated for oral cavity, oropharyngeal or hypopharyngeal cancer with tumour resection and microvascular free tissue transfer reconstruction at the Helsinki University Hospital, Helsinki, Finland...
January 27, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29325033/cancer-risk-in-older-people-living-with-human-immunodeficiency-virus-infection-in-the-united-states
#17
Parag Mahale, Eric A Engels, Anna E Coghill, Amy R Kahn, Meredith S Shiels
Background: Cancer risk is increased in people living with HIV (PLWH). Improved survival has led to an aging of PLWH. We evaluated the cancer risk in older PLWH (age ≥50 years). Methods: We included data from the HIV/AIDS Cancer Match Study (1996-2012) and evaluated risk of Kaposi sarcoma (KS), non-Hodgkin lymphoma (NHL), Hodgkin lymphoma, and cervical, anal, lung, liver, oral cavity/pharyngeal, breast, prostate, and colon cancers in older PLWH compared to the general population by calculating the standardized incidence ratios (SIRs) and excess absolute risks (EARs)...
January 8, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29290288/differences-in-incidence-and-survival-of-oral-cavity-and-pharyngeal-cancers-between-germany-and-the-united-states-depend-on-the-hpv-association-of-the-cancer-site
#18
L Jansen, N Buttmann-Schweiger, S Listl, M Ressing, B Holleczek, A Katalinic, S Luttmann, K Kraywinkel, H Brenner
INTRODUCTION: The epidemiology of squamous cell oral cavity and pharyngeal cancers (OCPC) has changed rapidly during the last years, possibly due to an increase of human papilloma virus (HPV) positive tumors and successes in tobacco prevention. Here, we compare incidence and survival of OCPC by HPV-relation of the site in Germany and the United States (US). MATERIALS AND METHODS: Age-standardized and age-specific incidence and 5-year relative survival was estimated using data from population-based cancer registries in Germany and the US Surveillance Epidemiology and End Results (SEER) 13 database...
January 2018: Oral Oncology
https://www.readbyqxmd.com/read/29285222/a-primary-tumor-gene-expression-signature-identifies-a-crucial-role-played-by-tumor-stroma-myofibroblasts-in-lymph-node-involvement-in-oral-squamous-cell-carcinoma
#19
Gianluigi Mazzoccoli, Stefano Castellana, Massimo Carella, Orazio Palumbo, Cristiana Tiberio, Caterina Fusilli, Daniele Capocefalo, Tommaso Biagini, Tommaso Mazza, Lorenzo Lo Muzio
Oral squamous cell carcinoma (OSCC) is the most common oral and pharyngeal cancer, and is responsible of approximately 3% of cancers in men and 2% in women in the Western World, with increasing incidence rates in developing countries. Early detection by screening is necessary to prevent fatal disease because early, curable lesions are rarely symptomatic. The overall 5-yr survival rate is approximately 50% when surgery, radiation, or both are employed as treatment options, but lymph node involvement greatly influences this estimate, by decreasing the survival rate by about 50%...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29284434/clinicopathological-factors-influencing-the-outcomes-of-surgical-treatment-in-patients-with-t4a-hypopharyngeal-cancer
#20
Sang-Yeon Kim, Young-Soo Rho, Eun-Chang Choi, Min-Sik Kim, Joo-Hyun Woo, Dong Hoon Lee, Eun Jae Chung, Min Woo Park, Da-Hee Kim, Young-Hoon Joo
BACKGROUND: The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer. METHODS: The present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients...
December 29, 2017: BMC Cancer
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