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Michael Schellenberger Costa, Arne Weigenand, Hong-Viet V Ngo, Lisa Marshall, Jan Born, Thomas Martinetz, Jens Christian Claussen
Few models exist that accurately reproduce the complex rhythms of the thalamocortical system that are apparent in measured scalp EEG and at the same time, are suitable for large-scale simulations of brain activity. Here, we present a neural mass model of the thalamocortical system during natural non-REM sleep, which is able to generate fast sleep spindles (12-15 Hz), slow oscillations (<1 Hz) and K-complexes, as well as their distinct temporal relations, and response to auditory stimuli. We show that with the inclusion of detailed calcium currents, the thalamic neural mass model is able to generate different firing modes, and validate the model with EEG-data from a recent sleep study in humans, where closed-loop auditory stimulation was applied...
September 2016: PLoS Computational Biology
Hong-Viet V Ngo, Arjan Miedema, Isabel Faude, Thomas Martinetz, Matthias Mölle, Jan Born
The <1 Hz EEG slow oscillation (SO) is a hallmark of slow-wave sleep (SWS) and is critically involved in sleep-associated memory formation. Previous studies showed that SOs and associated memory function can be effectively enhanced by closed-loop auditory stimulation, when clicks are presented in synchrony with upcoming SO up states. However, increasing SOs and synchronized excitability also bear the risk of emerging seizure activity, suggesting the presence of mechanisms in the healthy brain that counter developing hypersynchronicity during SOs...
April 29, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Dinh-Duc Nguyen, Ho-Phuong-Thuy Ngo, Myoung-ki Hong, Tan-Viet Pham, Jung Hun Lee, Jae Jin Lee, Dae Beom Kwon, Sang Hee Lee, Lin-Woo Kang
Acinetobacter baumannii has received much attention owing to its exceptional ability to develop resistance to currently available antibiotics. Alanine racemase (ALR) catalyzes the racemization of L-alanine to D-alanine with pyridoxal 5'-phosphate (PLP) as a cofactor. The D-alanine product is an essential component of the bacterial cell wall and ALR is a potential target for the development of novel antibacterial drugs. The alr gene from A. baumannii was cloned and the protein (AbALR) was expressed, purified and crystallized...
September 2013: Acta Crystallographica. Section F, Structural Biology and Crystallization Communications
Hong-Viet V Ngo, Thomas Martinetz, Jan Born, Matthias Mölle
Brain rhythms regulate information processing in different states to enable learning and memory formation. The <1 Hz sleep slow oscillation hallmarks slow-wave sleep and is critical to memory consolidation. Here we show in sleeping humans that auditory stimulation in phase with the ongoing rhythmic occurrence of slow oscillation up states profoundly enhances the slow oscillation rhythm, phase-coupled spindle activity, and, consequently, the consolidation of declarative memory. Stimulation out of phase with the ongoing slow oscillation rhythm remained ineffective...
May 8, 2013: Neuron
Hong-Viet V Ngo, Jens C Claussen, Jan Born, Matthias Mölle
Slow oscillations are electrical potential oscillations with a spectral peak frequency of ∼0.8 Hz, and hallmark the electroencephalogram during slow-wave sleep. Recent studies have indicated a causal contribution of slow oscillations to the consolidation of memories during slow-wave sleep, raising the question to what extent such oscillations can be induced by external stimulation. Here, we examined whether slow oscillations can be effectively induced by rhythmic acoustic stimulation. Human subjects were examined in three conditions: (i) with tones presented at a rate of 0...
February 2013: Journal of Sleep Research
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