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https://www.readbyqxmd.com/read/29772591/-monitoring-and-modern-hemodynamic-concepts-in-cardiac-anesthesia
#1
Matthias Heringlake, Christian Schmidt, Sebastian Brandt
Patients undergoing cardiac surgery are growing older, present with more comorbidities, and are frequently scheduled for more complex and prolonged surgical procedures. Routine application of neurological as well as extended hemodynamic monitoring combined with goal-directed perioperative hemodynamic optimization, targeting optimization of systemic and cerebral oxygen balance, show promise to reduce postoperative complications and to improve mortality in this high risk population. Expert recommendations suggest to avoid synthetic colloids for fluid optimization...
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29763687/therapeutic-efficacy-of-lipid-emulsions-of-docetaxel-linoleic-acid-conjugate-in-breast-cancer
#2
Tao Zhang, Meng Li, Ruyi Yang, Dong Zhang, Jibin Guan, Jiang Yu, Bin Yang, Huicong Zhang, Shenwu Zhang, Dan Liu, Yongjun Wang
Docetaxel (DTX) solution is among the most widely-used parenteral formulations used in advanced breast cancer therapy. However, severe side effects have been observed due to the use of ethanol and polysorbate 80. Herein, a novel DTX-based prodrug, docetaxel-linoleic acid conjugate (DTX-LA) was successfully synthesized. The high lipid solubility of DTX and DTX-LA resulted in a tendency for them to become entrapped in the oil core of the emulsions. As anticipated, nano-sized, sterically stabilized oil-in-water lipid emulsions (LMs) of DTX-LA LMs and DTX LMs were successfully constructed...
May 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29762138/theranostic-gold-magnetite-hybrid-nanoparticles-for-mri-guided-radiosensitization
#3
Devid Maniglio, Filippo Benetti, Luca Minati, Jorge Jovicich, Aldo Valentini, G Speranza, Claudio Migliaresi
The main limitation of drug-enhanced radiotherapy concerns the difficulty to evaluate the effectiveness of cancer targeting after drug administration hindering the standardization of therapies based on current radiosensitizing compounds. The challenge regards the development of systems able to combine imaging and radiotherapy enhancement in order to perform highly reliable cancer theragnosis. For these reasons, gold-magnetite hybrid nanoparticles are proposed as innovative theranostic nanotools for imaging-guided radiosensitization in cancer treatment...
May 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29750699/implementation-of-closed-loop-assisted-intra-operative-goal-directed-fluid-therapy-during-major-abdominal-surgery-a-case-control-study-with-propensity-matching
#4
Alexandre Joosten, Sean Coeckelenbergh, Amelie Delaporte, Brigitte Ickx, Jean Closset, Thierry Roumeguere, Luc Barvais, Luc Van Obbergh, Maxime Cannesson, Joseph Rinehart, Philippe Van der Linden
BACKGROUND: Goal-directed fluid therapy (GDFT) has been associated with improved patient outcomes. However, implementation of GDFT protocols remains low despite growing published evidence and the recommendations of multiple regulatory bodies in Europe. We developed a closed-loop-assisted GDFT management system linked to a pulse contour monitor to assist anaesthesiologists in applying GDFT. OBJECTIVE: To assess the impact of our closed-loop system in patients undergoing major abdominal surgery in an academic hospital without a GDFT programme...
May 9, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29747449/iron-oxide-colloidal-nanoclusters-as-theranostic-vehicles-and-their-interactions-at-the-cellular-level
#5
Athanasia Kostopoulou, Konstantinos Brintakis, Eirini Fragogeorgi, Amalia Anthousi, Liberato Manna, Sylvie Begin-Colin, Claire Billotey, Anthi Ranella, George Loudos, Irene Athanassakis, Alexandros Lappas
Advances in surfactant-assisted chemical approaches have led the way for the exploitation of nanoscale inorganic particles in medical diagnosis and treatment. In this field, magnetically-driven multimodal nanotools that perform both detection and therapy, well-designed in size, shape and composition, are highly advantageous. Such a theranostic material—which entails the controlled assembly of smaller (maghemite) nanocrystals in a secondary motif that is highly dispersible in aqueous media—is discussed here...
May 9, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29745073/hemodynamic-stability-achievement-by-application-of-goal-directed-fluid-therapy-with-different-infusion-solutions-in-colorectal-surgery
#6
Ana Cvetkovic, Nevena Kalezic, Biljana Milicic, Srdjan Nikolic, Milan Zegarac, Dejan Stojiljkovic, Merima Goran, Marina Stojanovic
PURPOSE: To determine whether there was a correlation between the type of administered infusion solutions intraoperatively with the quantity of administered infusion solutions, differences in values of cardiac output (CO) and cardiac index (CI) and need to use vasopressors and inotropes, between control and research groups. METHODS: This randomized prospective study included 55 patients with colorectal cancer. Subjects in the control group received only crystalloid solutions intraoperatively and postoperatively...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29733576/ph-sensitive-multi-ligand-gold-nanoplatform-targeting-carbonic-anhydrase-ix-enhances-the-delivery-of-doxorubicin-to-hypoxic-tumor-spheroids-and-overcomes-the-hypoxia-induced-chemoresistance
#7
Ahmed M Shabana, Utpal K Mondal, Md Raqibul Alam, Taylor Spoon, Codee Alicia Ross, Muniswamy Madesh, Claudiu T Supuran, Marc A Ilies
Hypoxia is a common feature of solid tumors contributing to resistance to chemotherapy. Selective delivery of chemotherapeutic drugs to hypoxic tumor niche remains an unsolved issue. For this purpose, we constructed a gold nanoplatform targeting carbonic anhydrase IX (CA IX) epitope, which is overexpressed in hypoxic tumor cells versus normal tissues. We designed compatible small MW carbonic anhydrase inhibitor ligands (CAI)- and doxorubicin (Dox)- ligands, and optimized protocols for AuNPs efficient decoration to achieve both good targeting ligand density and optimum drug loading, while preserving colloidal stability...
May 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29696011/topical-colloidal-silver-for-the-treatment-of-recalcitrant-chronic-rhinosinusitis
#8
Mian L Ooi, Katharina Richter, Catherine Bennett, Luis Macias-Valle, Sarah Vreugde, Alkis J Psaltis, Peter-John Wormald
Background: The management of recalcitrant chronic rhinosinusitis (CRS) is challenged by difficult-to-treat polymicrobial biofilms and multidrug resistant bacteria. This has led to the search for broad-spectrum non-antibiotic antimicrobial therapies. Colloidal silver (CS) has significant antibiofilm activity in vitro and in vivo against S. aureus, MRSA , and P. aeruginosa . However, due to the lack of scientific efficacy, it is only currently used as an alternative medicine. This is the first study looking at the safety and efficacy of CS in recalcitrant CRS...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29685796/fluids-and-organ-dysfunction-a-narrative-review-of-the-literature-and-discussion-of-5-controversial-topics
#9
Adam J Kingeter, Meredith A Kingeter, Andrew D Shaw
Evidence-based clinical decision making is at the forefront of modern cardiothoracic anesthesia practice. Therefore, as a field, cardiac anesthesiologist should strive to ensure that the available evidence is of the highest possible quality. In this narrative review, 5 important topics that the authors believe require additional investigation in cardiothoracic anesthesia and critical care related to fluid therapy and organ dysfunction are outlined briefly. In particular, the authors believe that the areas of pulmonary artery catheter use, restrictive versus liberal transfusion strategies, cardiopulmonary bypass prime composition, colloid use in resuscitation and its effects on acute kidney injury, and management of acute kidney injury after cardiac surgery hold many unanswered questions and opportunities for continued improvement in the specialty of cardiac anesthesia...
March 13, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29684688/layer-by-layer-hollow-photosensitizer-microcapsule-design-via-a-manganese-carbonate-hard-template-for-photodynamic-therapy-in-cells
#10
Andreza Ribeiro Simioni, Priscila Costa Carvalho de Jesus, Antonio Claudio Tedesco
BACKGROUND: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. In this paper, we describe a novel drug delivery system for loading photosensitizer drugs into hollow multilayered microcapsules for photoprocess applications...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29680675/far-red-light-mediated-programmable-anti-cancer-gene-delivery-in-cooperation-with-photodynamic-therapy
#11
Jinhui Wang, Hua He, Xin Xu, Xiao Wang, Yongbing Chen, Lichen Yin
Effective anti-cancer therapy is hurdled by the complicated extracellular and intracellular barriers, and thus a smart gene vector that can enable programmable gene delivery is highly demanded. Photo-manipulation of gene delivery processes features spatial and temporal precision, while majority of current strategies utilizes short-wavelength UV/visible light with poor tissue penetration or high-power-density near-infrared (NIR) light that would cause undesired heat damage. Herein, an ROS-degradable polycation was designed and co-delivered with a photosensitizer (PS), thus realizing photo-programmable gene delivery using far-red light (661 nm) at low optical power density (down to 5 mW cm-2 )...
April 12, 2018: Biomaterials
https://www.readbyqxmd.com/read/29680244/dynamical-behavior-of-somatostatin-14-and-its-cyclic-analogues-as-analyzed-in-bulk-and-on-plasmonic-silver-nanoparticles
#12
Belén Hernández, Yves-Marie Coïc, Eduardo López-Tobar, Santiago Sanchez-Cortes, Bruno Baron, Fernando Pflüger, Sergei G Kruglik, Régis Cohen, Mahmoud Ghomi
Primarily known as the inhibitor of growth hormone release, the role of somatostatin in many other inhibiting activities upon binding to its five G-protein-coupled receptors has been elucidated. Because of the short half-life of somatostatin, a number of synthetic analogues were elaborated for this peptide hormone. Herein, after recalling the main somatostatin therapeutic interests, we present the dynamical behavior of somatostatin-14 and its two currently used synthetic cyclic analogues, octreotide and pasireotide...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29672241/scintillation-yield-estimates-of-colloidal-cerium-doped-laf-3-nanoparticles-and-potential-for-deep-pdt
#13
Konstantin A Kudinov, Daniel R Cooper, Jonathan K Ha, Colin K Hill, Jay L Nadeau, Jan P Seuntjens, Stephen E Bradforth
A hybrid of radiotherapy and photodynamic therapy (PDT) has been proposed in previously reported studies. This approach utilizes scintillating nanoparticles to transfer energy to attached photosensitizers, thus generating singlet oxygen for local killing of malignant cells. Its effectiveness strongly depends upon the scintillation yield of the nanoparticles. Using a liquid scintillator as a reference standard, we estimated the scintillation yield of Ce0.1 La0.9 F3 /LaF3 core/shell nanoparticles at 28.9 mg/ml in water to be 350 photons/MeV under orthovoltage X-ray irradiation...
April 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29670350/colloidal-plasmonic-gold-nanoparticles-and-gold-nanorings-shape-dependent-generation-of-singlet-oxygen-and-their-performance-in-enhanced-photodynamic-cancer-therapy
#14
Yamin Yang, Yue Hu, Henry Du, Lei Ren, Hongjun Wang
Introduction: In recognition of the potentials of gold nanoparticles (Au NPs) in enhanced photodynamic therapy (PDT) for cancer, it is desirable to further understand the shape-dependent surface plasmonic resonance (SPR) properties of various gold nanostructures and evaluate their performances in PDT. Materials and methods: Monodispersed colloidal spherical solid Au NPs were synthesized by UV-assisted reduction using chloroauric acid and sodium citrate, and hollow gold nanorings (Au NRs) with similar outer diameter were synthesized based on sacrificial galvanic replacement method...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29644706/preparation-and-evaluation-of-188-re-sulfide-colloidal-nanoparticles-loaded-biodegradable-poly-l-lactic-acid-microspheres-for-radioembolization-therapy
#15
Mina Jamre, Mojtaba Shamsaei, Mostafa Erfani, Sodeh Sadjadi, Mohammad Ghannadi Maragheh
Radioembolization with radioactive microspheres has been an effective method for the treatment of liver lesions. The aim of this study was to prepare carrier-free 188 Re loaded poly (L-lactic acid) (PLLA) microspheres through 188 Re sulfide colloidal nanoparticles (188 Re-SC nanoparticles). The formation of 188 Re-SC nanoparticles was confirmed by ultraviolet-visible spectrophotometry. The labeling yield of 188 Re-SC nanoparticles was verified using the RTLC method. Effects of synthesis parameters on morphology and size of prepared 188 Re-sulfide colloidal-PLLA microspheres (188 Re-SC-PLLA microspheres) were studied by scanning electron microscopy...
April 12, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29626721/curcumin-loaded-ultradeformable-nanovesicles-as-a-potential-delivery-system-for-breast-cancer-therapy
#16
Salma M Abdel-Hafez, Rania M Hathout, Omaima A Sammour
In the current study, the transdermal route has been investigated to deliver the poorly bioavailable drug; curcumin into the systemic circulation, aiming to target both superficial and subcutaneous tumors such as the breast tumors. Accordingly, different colloidal carriers viz. ultradeformable nanovesicles comprising various penetration enhancers were exploited. Curcumin-loaded deformable vesicles were prepared by the thin film hydration method followed by extrusion. Sodium cholate and Tween 80 were set as standard edge activators and Labrasol, Transcutol, limonene and oleic acid were the penetration enhancers that were evaluated for their efficacy in skin permeation...
March 30, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29601720/radiotherapy-sensitized-tumor-photothermal-ablation-using-%C3%AE-polyglutamic-acid-nanogels-loaded-with-polypyrrole
#17
Yiwei Zhou, Yong Hu, Wenjie Sun, Shiyi Lu, Chao Cai, Chen Peng, Jing Yu, Rachela Popovtzer, Mingwu Shen, Xiangyang Shi
Development of versatile nanoscale platforms for cancer diagnosis and therapy is of great importance for applications in translational medicine. In this work, we present the use of γ-polyglutamic acid (γ-PGA) nanogels (NGs) to load polypyrrole (PPy) for thermal/photoacoustic (PA) imaging and radiotherapy (RT)-sensitized tumor photothermal therapy (PTT). First, a double emulsion approach was used to prepare the cystamine dihydrochloride (Cys)-crosslinked γ-PGA NGs. Next, the crosslinked NGs served as a reactor to be filled with pyrrole monomers that were subjected to in-situ oxidation polymerization in the existence of Fe(III) ions...
March 30, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29593416/influence-of-stroke-volume-variation-on-fluid-treatment-and-postoperative-complications-in-thoracic-surgery
#18
Cengiz Sahutoglu, Erbil Turksal, Seden Kocabas, Fatma Zekiye Askar
Background: Fluid management in critically ill patients usually relies on increasing preload to augment cardiac output. In the present study, we aimed to evaluate whether stroke volume variation (SVV) can guide fluid therapy and reduce complications. Patients and methods: In this retrospective study, a total of 88 patients who underwent lobectomy were divided into two groups: group 1 (SVV, n=43) and group 2 (conventional or central venous pressure [CVP], n=45). Heart rate, blood pressure, oxygen saturation, SVV (only group 1), CVP (all patients), urea, creatinine, and hemoglobin levels before and after surgery, use of fluid, blood and inotropic agents, and postoperative complications were recorded retrospectively...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29578169/clinical-research-of-goal-directed-fluid-therapy-in-elderly-patients-with-radical-resection-of-bladder-cancer
#19
Tie-Jun Liu, Jin-Cun Zhang, Xiao-Zeng Gao, Zhi-Bin Tan, Jian-Jun Wang, Pan-Pan Zhang, Ai-Bin Cheng, Shu-Bo Zhang
Objective: The aim of this study is to investigate the clinical effect of goal-directed fluid therapy in elderly patients with radical resection of bladder cancer. Materials and Methods: Seventy-six elderly patients with radical resection of bladder cancer were selected from October 2012 to October 2014 and randomly divided into two groups, in which 38 patients received routine treatment as the control group and 38 patients received goal-directed fluid therapy based on routine treatment as the observation group...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29577015/multifunctional-pegylated-albumin-ir780-iron-oxide-nanocomplexes-for-cancer-photothermal-therapy-and-mr-imaging
#20
Ssu-Yu Lin, Rih-Yang Huang, Wei-Chen Liao, Chun-Chiao Chuang, Chien-Wen Chang
A multifunctional albumin/superparamagnetic iron oxide nanoparticle (SPIO) nanocomplex system to deliver IR780, a photothermal agent, for cancer theranostic applications was proposed in this study. Single emulsion method was utilized to fabricate the human albumin/IR780/SPIO (HISP) nanocomplexes with a hydrophobic core (SPIO and IR780) and a hydrophilic shell (human serum albumin (HSA) and poly (ethylene glycol) (PEG)). Effects of PEGylation on the size and surface potential of nanocomplexes were analyzed. Nanospheres containing uniformly dispersed SPIO was observed using Transmission Electron Microscopy (TEM) imaging...
2018: Nanotheranostics
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