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https://www.readbyqxmd.com/read/28745294/controllable-synthesis-and-characterisation-of-palladium-ii-anticancer-complex-loaded-colloidal-gelatin-nanoparticles-as-a-novel-sustained-release-delivery-system-in-cancer-therapy
#1
Neda Alasvand, Maryam Saeidifar, Ali Akbar Saboury, Masoud Mozafari
Over the past few years, there have been several attempts to deliver anticancer drugs into the body. It has been shown that compared to other available carriers, colloidal gelatin nanoparticles (CGNPs) have distinct properties due to their exceptional physico-chemical and biological characteristics. In this study, a novel water-soluble palladium (II) anticancer complex was first synthesised, and then loaded into CGNPs. The CGNPs were synthesised through a two-step desolvation method with an average particle size of 378 nm...
August 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28744887/in-vitro-evaluation-of-the-internalization-and-toxicological-profile-of-silica-nanoparticles-and-submicroparticles-for-the-design-of-dermal-drug-delivery-strategies
#2
Sara Vicente, Claudia Moia, Huijun Zhu, Xavier Vigé
The use of colloidal silica nanoparticles and sub-microparticles (SiPs) have been considered a very interesting strategy for drug delivery applications. In the present study, we have focused our attention on the suitability of these nanomaterials as potential carriers for dermal drug delivery, thus studying their toxicological profile in vitro, cellular uptake and intracellular localization in both human keratinocytes (K17) and human dermal fibroblasts (HDF) as a function of their particle size (SiPs of 20, 70, 200 and 500 nm)...
July 25, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28742231/different-resuscitation-strategies-and-novel-pharmacologic-treatment-with-valproic-acid-in-traumatic-brain-injury
#3
REVIEW
Simone E Dekker, Vahagn C Nikolian, Martin Sillesen, Ted Bambakidis, Patrick Schober, Hasan B Alam
Traumatic brain injury (TBI) is a leading cause of death in young adults, and effective treatment strategies have the potential to save many lives. TBI results in coagulopathy, endothelial dysfunction, inflammation, cell death, and impaired epigenetic homeostasis, ultimately leading to morbidity and/or mortality. Commonly used resuscitation fluids such as crystalloids or colloids have several disadvantages and might even be harmful when administered in large quantities. There is a need for next-generation treatment strategies (especially in the prehospital setting) that minimize cellular damage, improve survival, and enhance neurological recovery...
July 25, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28735449/therapy-with-omeprazole-modulates-regulatory-t-cell-t-helper-17-immune-response-in-children-with-duodenal-ulcers
#4
Chuan-Ying Li, Cheng Wu
The purpose of this study was to determine the effect of omeprazole on the regulatory T cell (Treg) and T helper 17 (Th17)-mediated response in patients with duodenal ulcers (DUs). DU patients were randomly divided into omeprazole and colloid bismuth subcitrate treatment groups. The ratios of Th17 and Treg in peripheral blood mononuclear cells (PBMCs) were measured. Cytokine production and Foxp3(+)- and RORγt-positive cells were detected. The expressions of STAT3, p-STAT3, STAT5 and p-STAT5 were detected by Western blot...
July 22, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28726368/mussel-inspired-polydopamine-coated-lanthanide-nanoparticles-for-nir-ii-ct-dual-imaging-and-photothermal-therapy
#5
Yu Dai, Dongpeng Yang, Danping Yu, Cong Cao, Qiuhong Wang, Songhai Xie, Liang Shen, Wei Feng, Fuyou Li
Nanomedicine has attracted substantial attentions for accurate diagnosis or treatment of carcinoma in recent years. Nd3+ doped lanthanide nanophosphors based near-infrared-II (NIR-II) optical imaging is widely used for deep penetration tissue imaging while X-ray computed tomography (CT) is well-suited for in vivo imaging. Polymer coated lanthanide nanophosphors were increasingly used as both diagnostics and therapies for tumor in vivo. However, the bio-compatibility of nanocomposites and efficiency of tumor ablation should be taken into consideration when construct of a nanotheranostic probe...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28720256/efficacy-of-a-hydroactive-colloid-gel-versus-historical-controls-for-the-prevention-of-radiotherapy-induced-moist-desquamation-in-breast-cancer-patients
#6
Sandrine Censabella, Stefan Claes, Marc Orlandini, Roel Braekers, Paul Bulens
PURPOSE: Radiotherapy-induced moist desquamation (RIMD) is a complication that can affect patients' quality of life and jeopardize radiotherapy outcomes. The curative use of a hydroactive colloid gel has previously been shown effective in the management of RIMD in breast cancer patients. This study aimed at investigating the efficacy of this same gel but in the prevention of RIMD. METHODS: A group of breast cancer patients who applied the hydroactive gel from start to end of post-lumpectomy radiotherapy (Preventive Hydrogel group) were compared with two groups of matched historical controls: a group applying a dexpanthenol cream throughout their therapy and a group applying first the dexpanthenol cream then, after 11-14 fractions of radiotherapy, the hydroactive gel (Curative Hydrogel group)...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28711712/ex-vivo-and-in-vivo-evaluation-of-microemulsion-based-transdermal-delivery-of-e-coli-specific-t4-bacteriophage-a-rationale-approach-to-treat-bacterial-infection
#7
Vaibhav Rastogi, Pragya Yadav, Anurag Verma, Jayanta K Pandit
This study is focused on the development and evaluation of transdermal delivery of E. coli-specific T4 bacteriophages both ex-vivo and in-vivo using microemulsion as delivery carrier in eradicating the infection caused by E. coli. Microemulsions were prepared by mixing selected oil, surfactants and aqueous phase containing bacteriophages. The formulations were subjected to physicochemical characterization, ex-vivo and in-vivo permeation, stability studies, histological and immunofluorescence examination. The colloidal system exhibits a uniform size distribution, of finite size (150-320nm)...
July 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28709569/selected-active-naturals-for-atopic-dermatitis-atopic-dermatitis-part-1
#8
Nanette B Silverberg
The desire for naturally derived agents is a growing trend for patients, physicians, and pharmaceutical companies. Studies indicate that complementary and alternative medicine is often used by patients and parents of children with atopic dermatitis, not necessarily with beneficial results. A half-dozen natural agents (ie, topical agents: coconut oil, colloidal oatmeal, sunflower oil, mustard oil, glycerin, and oral Chinese herbal therapy) are discussed because they have become popular for their expected activity in the therapy of atopic dermatitis...
July 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28709375/examining-the-roles-of-emulsion-droplet-size-and-surfactant-in-the-interfacial-instability-based-fabrication-process-of-micellar-nanocrystals
#9
Yuxiang Sun, Ling Mei, Ning Han, Xinyi Ding, Caihao Yu, Wenjuan Yang, Gang Ruan
The interfacial instability process is an emerging general method to fabricate nanocrystal-encapsulated micelles (also called micellar nanocrystals) for biological detection, imaging, and therapy. The present work utilized fluorescent semiconductor nanocrystals (quantum dots or QDs) as the model nanocrystals to investigate the interfacial instability-based fabrication process of nanocrystal-encapsulated micelles. Our experimental results suggest intricate and intertwined roles of the emulsion droplet size and the surfactant poly (vinyl alcohol) (PVA) used in the fabrication process of QD-encapsulated poly (styrene-b-ethylene glycol) (PS-PEG) micelles...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28708385/chloroquine-modified-hydroxyethyl-starch-as-a-polymeric-drug-for-cancer-therapy
#10
Richard Sleightholm, Bin Yang, Fei Yu, Ying Xie, David Oupický
Hydroxyethyl starch (HES) is a clinically used polysaccharide colloidal plasma volume expander. The goal of this study was to synthesize HES modified with hydroxychloroquine (HCQ) as a novel polymeric drug with the ability to inhibit the invasive character of pancreatic cancer (PC) cells. HES was conjugated with HCQ using a simple carbonyldiimidazole coupling to prepare Chloroquine-modified HES (CQ-HES). CQ-HES with various degrees of HCQ substitution were synthesized and characterized. Atomic force microscopy was used to demonstrate a pH-dependent assembly of CQ-HES into well-defined nanoparticles...
July 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28697437/novel-ex-vivo-protocol-using-porcine-vagina-to-assess-drug-permeation-from-mucoadhesive-and-colloidal-pharmaceutical-systems
#11
Maíra N Pereira, Thaiene A Reis, Breno N Matos, Marcílio Cunha-Filho, Taís Gratieri, Guilherme M Gelfuso
Local treatment of vaginal diseases presents advantages over systemic treatments and the interaction of the drug delivery systems with the biological tissue is a key factor for a successful vaginal topical therapy. Conventional protocols for permeation studies have high variability and fail in distinguishing drug penetration from mucoadhesive or colloidal drug delivery systems from conventional formulations, as tissue interaction is normally under estimated. The protocol presented in this paper is a simplified ex vivo vertical model, in which formulations are placed in hung porcine vaginas with the objective of mimicking a condition closer to the biological circumstance, specifically considering the possible leak from the vaginal canal in the vertical position...
July 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28688286/co-delivery-of-a-growth-factor-and-a-tissue-protective-molecule-using-elastin-biopolymers-accelerates-wound-healing-in-diabetic-mice
#12
Julie Devalliere, Kevin Dooley, Yong Yu, Sarah S Kelangi, Basak E Uygun, Martin L Yarmush
Growth factor therapy is a promising approach for chronic diabetic wounds, but strategies to efficiently and cost-effectively deliver active molecules to the highly proteolytic wound environment remain as major obstacles. Here, we re-engineered keratinocyte growth factor (KGF) and the cellular protective peptide ARA290 into a protein polymer suspension with the purpose of increasing their proteolytic resistance, thus their activity in vivo. KGF and ARA290 were fused with elastin-like peptide (ELP), a protein polymer derived from tropoelastin, that confers the ability to separate into a colloidal suspension of liquid-like coacervates...
June 30, 2017: Biomaterials
https://www.readbyqxmd.com/read/28685231/hybrid-polymeric-protein-nano-carriers-hppnc-for-targeted-delivery-of-tgf%C3%AE-inhibitors-to-hepatocellular-carcinoma-cells
#13
Nemany A N Hanafy, Alessandra Quarta, Riccardo Di Corato, Luciana Dini, Concetta Nobile, Vittorianna Tasco, Sonia Carallo, Mariafrancesca Cascione, Andrea Malfettone, Jitka Soukupova, Rosaria Rinaldi, Isabel Fabregat, Stefano Leporatti
TGFβ1 pathway antagonists have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Inhibiting peptides, as P-17 in this study, are bound to either TGFβ1 or its receptors, blocking signal transduction. However, for efficient use of these TGFβ1antagonist as target therapeutic tools, improvement in their delivery is required. Here, a plasmid carrying specific shDNA (SHT-DNA), small interfering RNA (siRNA), and the peptide (P-17) were loaded separately into folic acid (FA)-functionalized nano-carriers made of Bovine Serum Albumin (BSA)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28682837/closed-loop-and-decision-assist-guided-fluid-therapy-of-human-hemorrhage
#14
Gabriel Hundeshagen, George C Kramer, Nicole Ribeiro Marques, Michael G Salter, Aristides K Koutrouvelis, Husong Li, Daneshvari R Solanki, Alexander Indrikovs, Roger Seeton, Sheryl N Henkel, Michael P Kinsky
OBJECTIVES: We sought to evaluate the efficacy, efficiency, and physiologic consequences of automated, endpoint-directed resuscitation systems and compare them to formula-based bolus resuscitation. DESIGN: Experimental human hemorrhage and resuscitation. SETTING: Clinical Research Laboratory. SUBJECTS: Healthy volunteers. INTERVENTIONS: Subjects (n = 7) were subjected to hemorrhage and underwent a randomized fluid resuscitation scheme on separate visits 1) formula-based bolus resuscitation; 2) semiautonomous (decision assist) fluid administration; and 3) fully autonomous (closed loop) resuscitation...
July 4, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28669194/nanoparticle-properties-for-delivery-to-cartilage-the-implications-of-disease-state-synovial-fluid-and-off-target-uptake
#15
Shannon Brown, Jake Pistiner, Isaac Adjei, Blanka Sharma
A major hurdle limiting the ability to treat and cure osteoarthritis, a common and debilitating disease, is rapid joint clearance and limited cartilage targeting of intra-articular therapies. Nano-scale drug carriers have the potential to improve therapeutic targeting and retention in the joint after direct injection, however, there still lacks a fundamental understanding of how the physiochemical properties of nanoparticles (NPs) influence localization to the degenerating cartilage and how joint conditions such as disease state and synovial fluid impact NP biodistribution...
July 1, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28663142/in-situ-dual-crosslinked-nanoparticles-for-tumor-targeting-gene-delivery
#16
Ying Zhang, Liang Liu, Lin Lin, Jie Chen, Huayu Tian, Xuesi Chen, Atsushi Maruyama
The instability of gene delivery systems and their "off-target" features are among the major hurdles in gene therapy. In this study, a facile fabrication platform is constructed to endow the gene delivery system with high stability in the circulation system and achieve targeted delivery of plasmid DNA (pDNA) into cancer cells. Aldehyde groups-bearing hyaluronic acid (HA-CHO) is initially synthesized through oxidation, and is then shielded on polyethylenimine/DNA (PEI/DNA) complex particles to form dual-crosslinked nanoparticles in situ...
June 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28661127/challenges-in-dna-delivery-and-recent-advances-in-multifunctional-polymeric-dna-delivery-systems
#17
Bingyang Shi, Meng Zheng, Wei Tao, Roger Chung, Dayong Jin, Dariush Ghaffari, Omid C Farokhzad
After more than 20 years of intensive investigations, gene therapy has become one of the most promising strategies for treating genetic diseases. However, the lack of ideal delivery systems has limited the clinical realization of gene therapy's tremendous potential, especially for DNA-based gene therapy. Over the past decade, considerable advances have been made in the application of polymer-based DNA delivery systems for gene therapy, especially through multifunctional systems. The core concept behind multifunctional polymeric DNA delivery systems is to endow one single DNA carrier, via materials engineering and surface modification, with several active functions, e...
July 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28653773/a-target-directed-chemo-photothermal-system-based-on-transferrin-and-copolymer-modified-mos%C3%A2-nanoplates-with-ph-activated-drug-release
#18
Jingquan Liu, Aitang Zhang, Aihua Li, Wenxue Tian, Zichao Li, Chen Wei, Yong Sun, Wei Zhao, Mengli Liu
Molybdenum disulfide (MoS₂) nanosheets have attracted significant attention due to its photothermal properties, but the poor solubility and colloidal stability limited its further application in biomedical field. Herein, we report a targeted photothermal controllable nanocarrier consisting of MoS₂ nanosheets modified with block copolymer P(OEG-A)-b-P(VBA-co-KH570) and targeting ligand transferrin. P(OEG-A)-b-P(VBA-co-KH570) is synthesized by RAFT polymerization and utilized not only to improve the solubility of MoS₂ nanosheets but also efficiently load the anti-cancer drug doxorubicin (DOX) via acid-cleavable Schiff base linker...
June 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28641543/zein-based-nanocarriers-as-potential-natural-alternatives-for-drug-and-gene-delivery-focus-on-cancer-therapy
#19
Ahmed Elzoghby, May Freag, Hadeer Mamdouh, Kadria Elkhodairy
Protein nanocarriers possess unique merits including minimal cytotoxicity, numerous renewable sources, and high drug-binding capability. In opposition to delivery carriers utilizing hydrophilic animal proteins, hydrophobic plant proteins (e.g, zein) have great tendency in fabricating controlled-release particulate carriers without additional chemical modification to stiffen them, which in turn evades the use of toxic chemical crosslinkers. Moreover, zein is related to a class of alcohol-soluble prolamins and generally recognized as safe (GRAS) carrier for drug delivery...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28635413/the-high-responder-a-review-of-pathophysiology-and-outcomes-during-ivf-treatment
#20
Mariano Mascarenhas, Adam H Balen
This review attempts to summarize the known literature on high responders to ovarian stimulation during assisted reproductive techniques (ART). Response to gonadotrophins is subject to significant interindividual and intercycle variation, thus carrying a risk of high response or poor response to ovarian stimulation regimens. The main risk for high responders is the development of ovarian hyperstimulation syndrome (OHSS) which is associated with significant morbidity. Hence, the definition of high responders in the literature has primarily focussed on risk factors for OHSS...
September 2017: Human Fertility: Journal of the British Fertility Society
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